Professor Daniel Walker

  • Affiliate Lecturer (School of Infection & Immunity)

email: Daniel.Walker@glasgow.ac.uk

B226 Level 2, Sii, Sir Graeme Davies Building, University Place, Glasgow G12 8TA

Import to contacts

ORCID iDhttps://orcid.org/0000-0002-4206-2942

Research interests

We aim to develop highly selective and potent protein antibiotics (bacteriocins) for the treatment of chronic bacterial infections and for use in agricultural applications. In addition, we are interested in determining the mechanism of action of bacteriocins, studying fundamental aspects of membrane biogenesis in Gram-negative bacteria and deleloping cross-linking stratagies for structural proteomics.

Current research projects include:

  1.  Protein antibiotics as novel therapeutic agents for the treatment of chronic biofilm-mediated infection.
  2.  Harnessing bacteriocins active against bacterial plant pathogens.
  3.  Mapping protein-protein interactions in the translocation and assembly module (TAM) complex involved in autotransporter biogenesis.
  4.  Development of cross-linking strategies for structural proteomics


Research Group Home Page

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2007 | 2006 | 2004 | 2003 | 2002 | 2001
Number of items: 59.

2024

Li, Xiang, Cole, John, Vaughan, Diane ORCID logoORCID: https://orcid.org/0000-0002-4530-2278, Xiao, Yinbo, Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 and Wall, Daniel M. ORCID logoORCID: https://orcid.org/0000-0002-0421-1951 (2024) Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohn’s disease associated adherent-invasive Escherichia coli infection. Microbiology, 170(6), 001470. (doi: 10.1099/mic.0.001470) (PMID:38916198)

Gerasimidis, Konstantinos ORCID logoORCID: https://orcid.org/0000-0001-9432-2200, Faqerah, Nojoud and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2024) Escherichia coli and diet in development and treatment of non-communicable diseases. From hypothesis generation to causation and formulation of dietary recommendations. Alimentary Pharmacology and Therapeutics, (Accepted for Publication)

2023

Faqerah, Nojoud, Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 and Gerasimidis, Konstantinos ORCID logoORCID: https://orcid.org/0000-0001-9432-2200 (2023) Review article: the complex interplay between diet and Escherichia coli in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 58(10), pp. 984-1004. (doi: 10.1111/apt.17720) (PMID:37771255)

Premsuriya, Jiraphan, Mosbahi, Khedidja, Atanaskovic, Iva, Kleanthous, Colin and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2023) Outer membrane translocation of pyocins via the copper regulated TonB-dependent transporter CrtA. Biochemical Journal, 480(14), pp. 1035-1049. (doi: 10.1042/BCJ20220552) (PMID:37399084) (PMCID:PMC10422930)

Li, Xiang, Ormsby, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-3991-2336, Fallata, Ghaith, Meikle, Lynsey M., Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942, Xu, Damo and Wall, Daniel M. ORCID logoORCID: https://orcid.org/0000-0002-0421-1951 (2023) PF-431396 hydrate inhibition of kinase phosphorylation during adherent-invasive Escherichia coli infection inhibits intra-macrophage replication and inflammatory cytokine release. Microbiology, 169(6), 001337. (doi: 10.1099/mic.0.001337) (PMID:37311220) (PMCID:PMC10333790)

2021

Carpena, Nuria ORCID logoORCID: https://orcid.org/0000-0002-1017-4499, Richards, Kerry, Bello Gonzalez, Teresita D. J., Bravo-Blas, Alberto, Housden, Nicholas G., Gerasimidis, Konstantinos ORCID logoORCID: https://orcid.org/0000-0001-9432-2200, Milling, Simon W.F. ORCID logoORCID: https://orcid.org/0000-0003-4384-5516, Douce, Gillian ORCID logoORCID: https://orcid.org/0000-0002-6654-7346, Malik, Danish J. and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2021) Targeted delivery of narrow-spectrum protein antibiotics to the lower gastrointestinal tract in a murine model of Escherichia coli colonization. Frontiers in Microbiology, 12, 670535. (doi: 10.3389/fmicb.2021.670535) (PMID:34721311) (PMCID:PMC8551963)

Chai, Ray, Rooney, William M. ORCID logoORCID: https://orcid.org/0000-0003-1623-8374, Milner, Joel J. ORCID logoORCID: https://orcid.org/0000-0003-3702-4295 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2021) Challenges of using protein antibiotics for pathogen control. Pest Management Science, 77(9), pp. 3836-3840. (doi: 10.1002/ps.6312) (PMID:33527621)

Six, Anne, Mosbahi, Khedidja, Barge, Madhuri, Kleanthous, Colin, Evans, Thomas ORCID logoORCID: https://orcid.org/0000-0002-4140-6352 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2021) Pyocin efficacy in a murine model of Pseudomonas aeruginosa sepsis. Journal of Antimicrobial Chemotherapy, 76(9), pp. 2317-2324. (doi: 10.1093/jac/dkab199) (PMID:34142136) (PMCID:PMC8361349)

2020

Wojnowska, Marta and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2020) FusB energizes import across the outer membrane through direct interaction with its ferredoxin substrate. mBio, 11(5), e02081-20. (doi: 10.1128/mBio.02081-20) (PMID:33109756) (PMCID:PMC7593965)

Rooney, William M ORCID logoORCID: https://orcid.org/0000-0003-1623-8374, Chai, Ray, Milner, Joel L. ORCID logoORCID: https://orcid.org/0000-0003-3702-4295 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2020) Bacteriocins targeting Gram-negative phytopathogenic bacteria: plantibiotics of the future. Frontiers in Microbiology, 11, 575981. (doi: 10.3389/fmicb.2020.575981) (PMCID:PMC7530242)

Atanaskovic, Iva, Mosbahi, Khedidja, Sharp, Connor, Housden, Nicholas G., Kaminska, Renata, Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 and Kleanthous, Colin (2020) Targeted killing of Pseudomonas aeruginosa by pyocin G occurs via the hemin transporter hur. Journal of Molecular Biology, 432(13), pp. 3869-3880. (doi: 10.1016/j.jmb.2020.04.020) (PMID:32339530) (PMCID:PMC7322526)

Rooney, William M. ORCID logoORCID: https://orcid.org/0000-0003-1623-8374, Grinter, Rhys W., Correia, Annapaula, Walker, Daniel C. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 and Milner, Joel J. ORCID logoORCID: https://orcid.org/0000-0003-3702-4295 (2020) Engineering bacteriocin-mediated resistance against the plant pathogen Pseudomonas syringae. Plant Biotechnology Journal, 18(5), pp. 1296-1306. (doi: 10.1111/pbi.13294) (PMID:31705720) (PMCID:PMC7152609)

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

Behrens, H. M. et al. (2020) Pyocin S5 import into Pseudomonas aeruginosa reveals a generic mode of bacteriocin transport. mBio, 11(2), e03230-19. (doi: 10.1128/mBio.03230-19) (PMID:32156826) (PMCID:PMC7064778)

Ormsby, M. et al. (2020) Propionic acid promotes the virulent phenotype of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. (doi: 10.1016/j.celrep.2020.01.078) (PMID:32075765) (PMCID:PMC7034058)

2019

The University Court Of The University of Glasgow (2019) Bacterial pathogen derived resistance in plants. .

Rooney, William M. ORCID logoORCID: https://orcid.org/0000-0003-1623-8374, Wojnowska, Marta and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2019) Draft genome sequence of the necrotrophic plant pathogenic bacterium Pectobacterium carotovorum subsp. carotovorum strain LMG 2410. Microbiology Resource Announcements, 8(31), e00614-19. (doi: 10.1128/MRA.00614-19) (PMID:31371540) (PMCID:PMC6675988)

Six, Anne, Krajangwong, Sakranmanee, Crumlish, Margaret, Zadoks, Ruth N. ORCID logoORCID: https://orcid.org/0000-0002-1164-8000 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2019) Galleria mellonella as an infection model for the multi-host pathogen Streptococcus agalactiae reflects hypervirulence of strains associated with human invasive disease. Virulence, 10(1), pp. 600-609. (doi: 10.1080/21505594.2019.1631660) (PMID:31230520) (PMCID:PMC6592362)

Irvine, Sharon, Bunk, Boyke, Bayes, Hannah K., Spröer, Cathrin, Connolly, James P.R., Six, Anne, Evans, Thomas J. ORCID logoORCID: https://orcid.org/0000-0002-4140-6352, Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134, Overmann, Jörg and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2019) Genomic and transcriptomic characterization of Pseudomonas aeruginosa small colony variants derived from a chronic infection model. Microbial Genomics, 5(4), (doi: 10.1099/mgen.0.000262) (PMID:30920365) (PMCID:PMC6521587)

Grinter, Rhys, Leung, Pok Man, Wijeyewickrema, Lakshmi C., Littler, Dene, Beckham, Simone, Pike, Robert N., Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942, Greening, Chris and Lithgow, Trevor (2019) Protease-associated import systems are widespread in Gram-negative bacteria. PLoS Genetics, 15(10), e1008435. (doi: 10.1371/journal.pgen.1008435)

2018

Mosbahi, Khedidja, Wojnowska, Marta, Albalat, Amaya and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2018) Bacterial iron acquisition mediated by outer membrane translocation and cleavage of a host protein. Proceedings of the National Academy of Sciences of the United States of America, 115(26), pp. 6840-6845. (doi: 10.1073/pnas.1800672115) (PMID:29891657) (PMCID:PMC6042079)

2017

Josts, Inokentijs, Stubenrauch, Christopher James, Vadlamani, Grishma, Mosbahi, Khedidja, Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942, Lithgow, Trevor and Grinter, Rhys (2017) The structure of a conserved domain of TamB reveals a hydrophobic β taco fold. Structure, 25(12), 1898-1906.e5. (doi: 10.1016/j.str.2017.10.002) (PMID:29129383) (PMCID:PMC5719984)

White, P. et al. (2017) Exploitation of an iron transporter for bacterial protein antibiotic import. Proceedings of the National Academy of Sciences of the United States of America, 114(45), pp. 12051-12056. (doi: 10.1073/pnas.1713741114) (PMID:29078392)

Behrens, Hannah M., Six, Anne, Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 and Kleanthous, Colin (2017) The therapeutic potential of bacteriocins as protein antibiotics. Emerging Topics in Life Sciences, 1(1), pp. 65-74. (doi: 10.1042/ETLS20160016)

2016

Grinter, R. et al. (2016) Structure of the bacterial plant-ferredoxin receptor FusA. Nature Communications, 7, 13308. (doi: 10.1038/ncomms13308) (PMID:27796364) (PMCID:PMC5095587)

Klein, Alexander, Wojdyla, Justyna Aleksandra, Joshi, Amar, Josts, Inokentijs, McCaughey, Laura C. ORCID logoORCID: https://orcid.org/0000-0001-5897-0163, Housden, Nicholas G., Kaminska, Renata, Byron, Olwyn ORCID logoORCID: https://orcid.org/0000-0001-7857-4520, Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 and Kleanthous, Colin (2016) Structural and biophysical analysis of nuclease protein antibiotics. Biochemical Journal, 473(18), pp. 2799-2812. (doi: 10.1042/bcj20160544) (PMID:27402794) (PMCID:PMC5264503)

McCaughey, Laura C. ORCID logoORCID: https://orcid.org/0000-0001-5897-0163, Josts, Inokentijs, Grinter, Rhys, White, Paul, Byron, Olwyn ORCID logoORCID: https://orcid.org/0000-0001-7857-4520, Tucker, Nicholas P., Matthews, Jacqueline M., Kleanthous, Colin, Whitchurch, Cynthia and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2016) Discovery, characterization and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa. Biochemical Journal, 473(15), pp. 2345-2358. (doi: 10.1042/bcj20160470) (PMID:27252387) (PMCID:PMC4964976)

McCaughey, Laura C., Ritchie, Neil D., Douce, Gillian R. ORCID logoORCID: https://orcid.org/0000-0002-6654-7346, Evans, Thomas J. ORCID logoORCID: https://orcid.org/0000-0002-4140-6352 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2016) Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection. Scientific Reports, 6, 30201. (doi: 10.1038/srep30201) (PMID:27444885) (PMCID:PMC4957109)

Ashraf, Khuram U., Josts, Inokentijs, Mosbahi, Khedidja, Kelly, Sharon M. ORCID logoORCID: https://orcid.org/0000-0002-3516-1387, Byron, Olwyn ORCID logoORCID: https://orcid.org/0000-0001-7857-4520, Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2016) The potassium binding protein Kbp is a cytoplasmic potassium sensor. Structure, 24(5), pp. 741-749. (doi: 10.1016/j.str.2016.03.017) (PMID:27112601)

Connolly, James P. R., Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Goldstone, Robert J., Grinter, Rhys, Wang, Dai, Cogdell, Richard J. ORCID logoORCID: https://orcid.org/0000-0003-2119-6607, Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942, Smith, David G. E. and Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 (2016) A highly conserved bacterial d-serine uptake system links host metabolism and virulence. PLoS Pathogens, 12(1), e1005359. (doi: 10.1371/journal.ppat.1005359) (PMID:26727373) (PMCID:PMC4699771)

2015

Brown, Carla L., Smith, Karen, Wall, Daniel ORCID logoORCID: https://orcid.org/0000-0002-0421-1951 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2015) Activity of species-specific antibiotics against Crohnʼs disease–associated adherent-invasive Escherichia coli. Inflammatory Bowel Diseases, 21(10), pp. 2372-2382. (doi: 10.1097/MIB.0000000000000488) (PMID:26177305)

Joshi, A. et al. (2015) Structures of the ultra-high-affinity protein–protein complexes of pyocins S2 and AP41 and their cognate immunity proteins from pseudomonas aeruginosa. Journal of Molecular Biology, 427(17), pp. 2852-2866. (doi: 10.1016/j.jmb.2015.07.014) (PMID:26215615) (PMCID:PMC4548480)

Fyfe, C.D., Grinter, R., Josts, I., Mosbahi, K., Roszak, A.W., Cogdell, R.J. ORCID logoORCID: https://orcid.org/0000-0003-2119-6607, Wall, D.M. ORCID logoORCID: https://orcid.org/0000-0002-0421-1951, Burchmore, R.J.S. ORCID logoORCID: https://orcid.org/0000-0003-1663-9004, Byron, O. ORCID logoORCID: https://orcid.org/0000-0001-7857-4520 and Walker, D. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2015) Structure of protease-cleaved escherichia coliα-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment. Acta Crystallographica. Section D: Biological Crystallography, 71(7), pp. 1478-1486. (doi: 10.1107/s1399004715008548) (PMID:26143919) (PMCID:PMC4498604)

Papadakos, Grigorios, Sharma, Amit, Lancaster, Lorna E., Bowen, Rebecca, Kaminska, Renata, Leech, Andrew P., Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942, Redfield, Christina and Kleanthous, Colin (2015) Consequences of inducing intrinsic disorder in a high-affinity protein–protein interaction. Journal of the American Chemical Society, 137(16), pp. 5252-5255. (doi: 10.1021/ja512607r) (PMID:25856265)

2014

Grinter, Rhys, Josts, Inokentijs, Zeth, Kornelius, Roszak, Aleksander W., McCaughey, Laura C. ORCID logoORCID: https://orcid.org/0000-0001-5897-0163, Cogdell, Richard J. ORCID logoORCID: https://orcid.org/0000-0003-2119-6607, Milner, Joel J. ORCID logoORCID: https://orcid.org/0000-0003-3702-4295, Kelly, Sharon M., Byron, Olwyn ORCID logoORCID: https://orcid.org/0000-0001-7857-4520 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2014) Structure of the atypical bacteriocin pectocin M2 implies a novel mechanism of protein uptake. Molecular Microbiology, 93(2), pp. 234-246. (doi: 10.1111/mmi.12655) (PMID:24865810) (PMCID:PMC4671253)

McCaughey, L. C. et al. (2014) Lectin-like bacteriocins from Pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor. PLoS Pathogens, 10(2), e1003898. (doi: 10.1371/journal.ppat.1003898) (PMID:24516380) (PMCID:PMC3916391)

Josts, Inokentijs, Grinter, Rhys, Kelly, Sharon M. ORCID logoORCID: https://orcid.org/0000-0002-3516-1387, Mosbahi, Khedidja, Roszak, Aleksander, Cogdell, Richard ORCID logoORCID: https://orcid.org/0000-0003-2119-6607, Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168, Byron, Olwyn ORCID logoORCID: https://orcid.org/0000-0001-7857-4520 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2014) Recombinant expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal DUF490963–1138 domain of TamB from Escherichia coli. Acta Crystallographica. Section F: Structural Biology Communications, 70(9), pp. 1272-1275. (doi: 10.1107/S2053230X14017403)

2013

Grinter, R., Milner, J. ORCID logoORCID: https://orcid.org/0000-0003-3702-4295 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2013) Beware of proteins bearing gifts: protein antibiotics that use iron as a Trojan horse. FEMS Microbiology Letters, 338(1), pp. 1-9. (doi: 10.1111/1574-6968.12011)

Dunne, K.A. et al. (2013) Increased S-nitrosylation and proteasomal degradation of caspase-3 during infection contribute to the persistence of adherent invasive escherichia coli (AIEC) in immune cells. PLoS ONE, 8(7), e68386. (doi: 10.1371/journal.pone.0068386) (PMID:23861899) (PMCID:PMC3701656)

2012

Brown, Carla L., Smith, Karen, McCaughey, Laura ORCID logoORCID: https://orcid.org/0000-0001-5897-0163 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2012) Colicin-like bacteriocins as novel therapeutic agents for the treatment of chronic biofilm-mediated infection. Biochemical Society Transactions, 40(6), pp. 1549-1552. (doi: 10.1042/BST20120241) (PMID:23176515)

Grinter, R., Milner, J. and Walker, D. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2012) Bacteriocins active against plant pathogenic bacteria. Biochemical Society Transactions, 40(6), pp. 1498-1502. (doi: 10.1042/BST20120206)

Penfold, C.N., Walker, D. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 and Kleanthous, C. (2012) How bugs kill bugs: progress and challenges in bacteriocin research. Biochemical Society Transactions, 40(6), pp. 1433-1437. (doi: 10.1042/BST20120253)

Grinter, R., Roszak, A.W., Cogdell, R.J. ORCID logoORCID: https://orcid.org/0000-0003-2119-6607, Milner, J.J. ORCID logoORCID: https://orcid.org/0000-0003-3702-4295 and Walker, D. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2012) The crystal structure of the lipid II-degrading bacteriocin syringacin M suggests unexpected evolutionary relationships between colicin M-like bacteriocins. Journal of Biological Chemistry, 287(46), pp. 38876-38888. (doi: 10.1074/jbc.M112.400150)

Smith, K., Martin, L., Rinaldi, A., Rajendran, R., Ramage, G. and Walker, D. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2012) Activity of Pyocin S2 against Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy, 56(3), pp. 1599-1601. (doi: 10.1128/AAC.05714-11)

Grinter, R., Milner, J. ORCID logoORCID: https://orcid.org/0000-0003-3702-4295 and Walker, D. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2012) Ferredoxin containing bacteriocins suggest a novel mechanism of iron uptake in Pectobacterium spp. PLoS ONE, 7(3), e33033. (doi: 10.1371/journal.pone.0033033) (PMID:22427936) (PMCID:PMC3302902)

Selkrig, J. et al. (2012) Discovery of an archetypal protein transport system in bacterial outer membranes. Nature Structural and Molecular Biology, 19(5), pp. 506-510. (doi: 10.1038/nsmb.2261)

2007

Walker, D, Moshbahi, K, Vankemmelbeke, M, James, R and Kleanthous, C (2007) The role of electrostatics in colicin nuclease domain translocation into bacterial cells. Journal of Biological Chemistry, 282, pp. 31389-31397. (doi: 10.1074/jbc.M705883200)

2006

Loftus, SR, Walker, D, Mate, MJ, Bonsor, DA, James, R, Moore, GR and Kleanthous, C (2006) Competitive recruitment of the periplasmic translocation portal TolB by a natively disordered domain of colicin E9. Proceedings of the National Academy of Sciences of the United States of America, 103(33), pp. 12353-12358. (doi: 10.1073/pnas.0603433103)

Mosbahi, K, Walker, D, James, R, Moore, GR and Kleanthous, C (2006) Global structural rearrangement of the cell penetrating ribonuclease colicin E3 on interaction with phospholipid membranes. Protein Science, 15, pp. 620-627. (doi: 10.1110/ps.051890306)

2004

Mosbahi, K, Walker, D, Lea, E, Moore, GR, James, R and Kleanthous, C (2004) Destabilization of the colicin E9 endonuclease domain by interaction with negatively charged phospholipids - Implications for colicin translocation into bacteria. Journal of Biological Chemistry, 279, pp. 22145-22151. (doi: 10.1074/jbc.M400402200)

Walker, D, Lancaster, L, James, R and Kleanthous, C (2004) Identification of the catalytic motif of the microbial ribosome inactivating cytotoxin colicin E3. Protein Science, 13, pp. 1603-1611.

Walker, D, Rolfe, M, Thompson, A, Moore, GR, James, R, Hinton, JCD and Kleanthous, C (2004) Transcriptional profiling of colicin-induced cell death of Escherichia coli MG1655 identifies potential mechanisms by which bacteriocins promote bacterial diversity. Journal of Bacteriology, 186, pp. 866-869. (doi: 10.1128/JB.186.3.866-869.2004)

2003

Law, Christopher J., Penfold, Christopher N., Walker, Daniel C. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942, Moore, Geoffrey R., James, Richard and Kleanthous, Colin (2003) OmpF enhances the ability of BtuB to protect susceptible Escherichia coli cells from colicin E9 cytotoxicity. FEBS Letters, 545(2-3), pp. 127-132. (doi: 10.1016/S0014-5793(03)00511-8)

Walker, D, Moore, GR, James, R and Kleanthous, C (2003) Thermodynamic consequences of bipartite immunity protein binding to the ribosomal ribonuclease colicin E3. Biochemistry, 42, pp. 4161-4171. (doi: 10.1021/bi0273720)

2002

McEwan, Alastair G., Lewin, Allison, Davy, Sharon L., Boetzel, Ruth, Leech, Andrew, Walker, Daniel, Wood, Tania and Moore, Geoffrey R. (2002) PrrC from Rhodobacter sphaeroides, a homologue of eukaryotic Sco proteins, is a copper-binding protein and may have a thiol-disulfide oxidoreductase activity. FEBS Letters, 518(1-3), pp. 10-16. (doi: 10.1016/S0014-5793(02)02532-2)

McAllen, R, Walker, D and Taylor, A (2002) The environmental effects of salinity and temperature on the oxygen consumption and total body osmolality of the marine flatworm Procerodes littoralis. Journal of Experimental Marine Biology and Ecology, 268, pp. 103-113.

Walker, DC, Georgiou, T, Pommer, AJ, Walker, D, Moore, GR, Kleanthous, C and James, R (2002) Mutagenic scan of the H-N-H motif of colicin E9: implications for the mechanistic enzymology of colicins, homing enzymes and apoptotic endonucleases. Nucleic Acids Research, 30, pp. 3225-3234.

2001

Pommer, A.J. et al. (2001) Mechanism and cleavage specificity of the H-N-H endonuclease colicin E9. Journal of Molecular Biology, 314(4), pp. 735-749. (doi: 10.1006/jmbi.2001.5189)

Kleanthous, Colin and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2001) Immunity proteins: enzyme inhibitors that avoid the active site. Trends in Biochemical Sciences, 26(10), pp. 624-631. (doi: 10.1016/S0968-0004(01)01941-7) (PMID:11590016)

This list was generated on Sun Jun 15 14:13:06 2025 BST.
Jump to: Articles | Patents
Number of items: 59.

Articles

Li, Xiang, Cole, John, Vaughan, Diane ORCID logoORCID: https://orcid.org/0000-0002-4530-2278, Xiao, Yinbo, Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 and Wall, Daniel M. ORCID logoORCID: https://orcid.org/0000-0002-0421-1951 (2024) Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohn’s disease associated adherent-invasive Escherichia coli infection. Microbiology, 170(6), 001470. (doi: 10.1099/mic.0.001470) (PMID:38916198)

Gerasimidis, Konstantinos ORCID logoORCID: https://orcid.org/0000-0001-9432-2200, Faqerah, Nojoud and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2024) Escherichia coli and diet in development and treatment of non-communicable diseases. From hypothesis generation to causation and formulation of dietary recommendations. Alimentary Pharmacology and Therapeutics, (Accepted for Publication)

Faqerah, Nojoud, Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 and Gerasimidis, Konstantinos ORCID logoORCID: https://orcid.org/0000-0001-9432-2200 (2023) Review article: the complex interplay between diet and Escherichia coli in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 58(10), pp. 984-1004. (doi: 10.1111/apt.17720) (PMID:37771255)

Premsuriya, Jiraphan, Mosbahi, Khedidja, Atanaskovic, Iva, Kleanthous, Colin and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2023) Outer membrane translocation of pyocins via the copper regulated TonB-dependent transporter CrtA. Biochemical Journal, 480(14), pp. 1035-1049. (doi: 10.1042/BCJ20220552) (PMID:37399084) (PMCID:PMC10422930)

Li, Xiang, Ormsby, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-3991-2336, Fallata, Ghaith, Meikle, Lynsey M., Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942, Xu, Damo and Wall, Daniel M. ORCID logoORCID: https://orcid.org/0000-0002-0421-1951 (2023) PF-431396 hydrate inhibition of kinase phosphorylation during adherent-invasive Escherichia coli infection inhibits intra-macrophage replication and inflammatory cytokine release. Microbiology, 169(6), 001337. (doi: 10.1099/mic.0.001337) (PMID:37311220) (PMCID:PMC10333790)

Carpena, Nuria ORCID logoORCID: https://orcid.org/0000-0002-1017-4499, Richards, Kerry, Bello Gonzalez, Teresita D. J., Bravo-Blas, Alberto, Housden, Nicholas G., Gerasimidis, Konstantinos ORCID logoORCID: https://orcid.org/0000-0001-9432-2200, Milling, Simon W.F. ORCID logoORCID: https://orcid.org/0000-0003-4384-5516, Douce, Gillian ORCID logoORCID: https://orcid.org/0000-0002-6654-7346, Malik, Danish J. and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2021) Targeted delivery of narrow-spectrum protein antibiotics to the lower gastrointestinal tract in a murine model of Escherichia coli colonization. Frontiers in Microbiology, 12, 670535. (doi: 10.3389/fmicb.2021.670535) (PMID:34721311) (PMCID:PMC8551963)

Chai, Ray, Rooney, William M. ORCID logoORCID: https://orcid.org/0000-0003-1623-8374, Milner, Joel J. ORCID logoORCID: https://orcid.org/0000-0003-3702-4295 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2021) Challenges of using protein antibiotics for pathogen control. Pest Management Science, 77(9), pp. 3836-3840. (doi: 10.1002/ps.6312) (PMID:33527621)

Six, Anne, Mosbahi, Khedidja, Barge, Madhuri, Kleanthous, Colin, Evans, Thomas ORCID logoORCID: https://orcid.org/0000-0002-4140-6352 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2021) Pyocin efficacy in a murine model of Pseudomonas aeruginosa sepsis. Journal of Antimicrobial Chemotherapy, 76(9), pp. 2317-2324. (doi: 10.1093/jac/dkab199) (PMID:34142136) (PMCID:PMC8361349)

Wojnowska, Marta and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2020) FusB energizes import across the outer membrane through direct interaction with its ferredoxin substrate. mBio, 11(5), e02081-20. (doi: 10.1128/mBio.02081-20) (PMID:33109756) (PMCID:PMC7593965)

Rooney, William M ORCID logoORCID: https://orcid.org/0000-0003-1623-8374, Chai, Ray, Milner, Joel L. ORCID logoORCID: https://orcid.org/0000-0003-3702-4295 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2020) Bacteriocins targeting Gram-negative phytopathogenic bacteria: plantibiotics of the future. Frontiers in Microbiology, 11, 575981. (doi: 10.3389/fmicb.2020.575981) (PMCID:PMC7530242)

Atanaskovic, Iva, Mosbahi, Khedidja, Sharp, Connor, Housden, Nicholas G., Kaminska, Renata, Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 and Kleanthous, Colin (2020) Targeted killing of Pseudomonas aeruginosa by pyocin G occurs via the hemin transporter hur. Journal of Molecular Biology, 432(13), pp. 3869-3880. (doi: 10.1016/j.jmb.2020.04.020) (PMID:32339530) (PMCID:PMC7322526)

Rooney, William M. ORCID logoORCID: https://orcid.org/0000-0003-1623-8374, Grinter, Rhys W., Correia, Annapaula, Walker, Daniel C. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 and Milner, Joel J. ORCID logoORCID: https://orcid.org/0000-0003-3702-4295 (2020) Engineering bacteriocin-mediated resistance against the plant pathogen Pseudomonas syringae. Plant Biotechnology Journal, 18(5), pp. 1296-1306. (doi: 10.1111/pbi.13294) (PMID:31705720) (PMCID:PMC7152609)

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

Behrens, H. M. et al. (2020) Pyocin S5 import into Pseudomonas aeruginosa reveals a generic mode of bacteriocin transport. mBio, 11(2), e03230-19. (doi: 10.1128/mBio.03230-19) (PMID:32156826) (PMCID:PMC7064778)

Ormsby, M. et al. (2020) Propionic acid promotes the virulent phenotype of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. (doi: 10.1016/j.celrep.2020.01.078) (PMID:32075765) (PMCID:PMC7034058)

Rooney, William M. ORCID logoORCID: https://orcid.org/0000-0003-1623-8374, Wojnowska, Marta and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2019) Draft genome sequence of the necrotrophic plant pathogenic bacterium Pectobacterium carotovorum subsp. carotovorum strain LMG 2410. Microbiology Resource Announcements, 8(31), e00614-19. (doi: 10.1128/MRA.00614-19) (PMID:31371540) (PMCID:PMC6675988)

Six, Anne, Krajangwong, Sakranmanee, Crumlish, Margaret, Zadoks, Ruth N. ORCID logoORCID: https://orcid.org/0000-0002-1164-8000 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2019) Galleria mellonella as an infection model for the multi-host pathogen Streptococcus agalactiae reflects hypervirulence of strains associated with human invasive disease. Virulence, 10(1), pp. 600-609. (doi: 10.1080/21505594.2019.1631660) (PMID:31230520) (PMCID:PMC6592362)

Irvine, Sharon, Bunk, Boyke, Bayes, Hannah K., Spröer, Cathrin, Connolly, James P.R., Six, Anne, Evans, Thomas J. ORCID logoORCID: https://orcid.org/0000-0002-4140-6352, Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134, Overmann, Jörg and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2019) Genomic and transcriptomic characterization of Pseudomonas aeruginosa small colony variants derived from a chronic infection model. Microbial Genomics, 5(4), (doi: 10.1099/mgen.0.000262) (PMID:30920365) (PMCID:PMC6521587)

Grinter, Rhys, Leung, Pok Man, Wijeyewickrema, Lakshmi C., Littler, Dene, Beckham, Simone, Pike, Robert N., Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942, Greening, Chris and Lithgow, Trevor (2019) Protease-associated import systems are widespread in Gram-negative bacteria. PLoS Genetics, 15(10), e1008435. (doi: 10.1371/journal.pgen.1008435)

Mosbahi, Khedidja, Wojnowska, Marta, Albalat, Amaya and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2018) Bacterial iron acquisition mediated by outer membrane translocation and cleavage of a host protein. Proceedings of the National Academy of Sciences of the United States of America, 115(26), pp. 6840-6845. (doi: 10.1073/pnas.1800672115) (PMID:29891657) (PMCID:PMC6042079)

Josts, Inokentijs, Stubenrauch, Christopher James, Vadlamani, Grishma, Mosbahi, Khedidja, Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942, Lithgow, Trevor and Grinter, Rhys (2017) The structure of a conserved domain of TamB reveals a hydrophobic β taco fold. Structure, 25(12), 1898-1906.e5. (doi: 10.1016/j.str.2017.10.002) (PMID:29129383) (PMCID:PMC5719984)

White, P. et al. (2017) Exploitation of an iron transporter for bacterial protein antibiotic import. Proceedings of the National Academy of Sciences of the United States of America, 114(45), pp. 12051-12056. (doi: 10.1073/pnas.1713741114) (PMID:29078392)

Behrens, Hannah M., Six, Anne, Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 and Kleanthous, Colin (2017) The therapeutic potential of bacteriocins as protein antibiotics. Emerging Topics in Life Sciences, 1(1), pp. 65-74. (doi: 10.1042/ETLS20160016)

Grinter, R. et al. (2016) Structure of the bacterial plant-ferredoxin receptor FusA. Nature Communications, 7, 13308. (doi: 10.1038/ncomms13308) (PMID:27796364) (PMCID:PMC5095587)

Klein, Alexander, Wojdyla, Justyna Aleksandra, Joshi, Amar, Josts, Inokentijs, McCaughey, Laura C. ORCID logoORCID: https://orcid.org/0000-0001-5897-0163, Housden, Nicholas G., Kaminska, Renata, Byron, Olwyn ORCID logoORCID: https://orcid.org/0000-0001-7857-4520, Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 and Kleanthous, Colin (2016) Structural and biophysical analysis of nuclease protein antibiotics. Biochemical Journal, 473(18), pp. 2799-2812. (doi: 10.1042/bcj20160544) (PMID:27402794) (PMCID:PMC5264503)

McCaughey, Laura C. ORCID logoORCID: https://orcid.org/0000-0001-5897-0163, Josts, Inokentijs, Grinter, Rhys, White, Paul, Byron, Olwyn ORCID logoORCID: https://orcid.org/0000-0001-7857-4520, Tucker, Nicholas P., Matthews, Jacqueline M., Kleanthous, Colin, Whitchurch, Cynthia and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2016) Discovery, characterization and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa. Biochemical Journal, 473(15), pp. 2345-2358. (doi: 10.1042/bcj20160470) (PMID:27252387) (PMCID:PMC4964976)

McCaughey, Laura C., Ritchie, Neil D., Douce, Gillian R. ORCID logoORCID: https://orcid.org/0000-0002-6654-7346, Evans, Thomas J. ORCID logoORCID: https://orcid.org/0000-0002-4140-6352 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2016) Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection. Scientific Reports, 6, 30201. (doi: 10.1038/srep30201) (PMID:27444885) (PMCID:PMC4957109)

Ashraf, Khuram U., Josts, Inokentijs, Mosbahi, Khedidja, Kelly, Sharon M. ORCID logoORCID: https://orcid.org/0000-0002-3516-1387, Byron, Olwyn ORCID logoORCID: https://orcid.org/0000-0001-7857-4520, Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2016) The potassium binding protein Kbp is a cytoplasmic potassium sensor. Structure, 24(5), pp. 741-749. (doi: 10.1016/j.str.2016.03.017) (PMID:27112601)

Connolly, James P. R., Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Goldstone, Robert J., Grinter, Rhys, Wang, Dai, Cogdell, Richard J. ORCID logoORCID: https://orcid.org/0000-0003-2119-6607, Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942, Smith, David G. E. and Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 (2016) A highly conserved bacterial d-serine uptake system links host metabolism and virulence. PLoS Pathogens, 12(1), e1005359. (doi: 10.1371/journal.ppat.1005359) (PMID:26727373) (PMCID:PMC4699771)

Brown, Carla L., Smith, Karen, Wall, Daniel ORCID logoORCID: https://orcid.org/0000-0002-0421-1951 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2015) Activity of species-specific antibiotics against Crohnʼs disease–associated adherent-invasive Escherichia coli. Inflammatory Bowel Diseases, 21(10), pp. 2372-2382. (doi: 10.1097/MIB.0000000000000488) (PMID:26177305)

Joshi, A. et al. (2015) Structures of the ultra-high-affinity protein–protein complexes of pyocins S2 and AP41 and their cognate immunity proteins from pseudomonas aeruginosa. Journal of Molecular Biology, 427(17), pp. 2852-2866. (doi: 10.1016/j.jmb.2015.07.014) (PMID:26215615) (PMCID:PMC4548480)

Fyfe, C.D., Grinter, R., Josts, I., Mosbahi, K., Roszak, A.W., Cogdell, R.J. ORCID logoORCID: https://orcid.org/0000-0003-2119-6607, Wall, D.M. ORCID logoORCID: https://orcid.org/0000-0002-0421-1951, Burchmore, R.J.S. ORCID logoORCID: https://orcid.org/0000-0003-1663-9004, Byron, O. ORCID logoORCID: https://orcid.org/0000-0001-7857-4520 and Walker, D. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2015) Structure of protease-cleaved escherichia coliα-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment. Acta Crystallographica. Section D: Biological Crystallography, 71(7), pp. 1478-1486. (doi: 10.1107/s1399004715008548) (PMID:26143919) (PMCID:PMC4498604)

Papadakos, Grigorios, Sharma, Amit, Lancaster, Lorna E., Bowen, Rebecca, Kaminska, Renata, Leech, Andrew P., Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942, Redfield, Christina and Kleanthous, Colin (2015) Consequences of inducing intrinsic disorder in a high-affinity protein–protein interaction. Journal of the American Chemical Society, 137(16), pp. 5252-5255. (doi: 10.1021/ja512607r) (PMID:25856265)

Grinter, Rhys, Josts, Inokentijs, Zeth, Kornelius, Roszak, Aleksander W., McCaughey, Laura C. ORCID logoORCID: https://orcid.org/0000-0001-5897-0163, Cogdell, Richard J. ORCID logoORCID: https://orcid.org/0000-0003-2119-6607, Milner, Joel J. ORCID logoORCID: https://orcid.org/0000-0003-3702-4295, Kelly, Sharon M., Byron, Olwyn ORCID logoORCID: https://orcid.org/0000-0001-7857-4520 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2014) Structure of the atypical bacteriocin pectocin M2 implies a novel mechanism of protein uptake. Molecular Microbiology, 93(2), pp. 234-246. (doi: 10.1111/mmi.12655) (PMID:24865810) (PMCID:PMC4671253)

McCaughey, L. C. et al. (2014) Lectin-like bacteriocins from Pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor. PLoS Pathogens, 10(2), e1003898. (doi: 10.1371/journal.ppat.1003898) (PMID:24516380) (PMCID:PMC3916391)

Josts, Inokentijs, Grinter, Rhys, Kelly, Sharon M. ORCID logoORCID: https://orcid.org/0000-0002-3516-1387, Mosbahi, Khedidja, Roszak, Aleksander, Cogdell, Richard ORCID logoORCID: https://orcid.org/0000-0003-2119-6607, Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168, Byron, Olwyn ORCID logoORCID: https://orcid.org/0000-0001-7857-4520 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2014) Recombinant expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal DUF490963–1138 domain of TamB from Escherichia coli. Acta Crystallographica. Section F: Structural Biology Communications, 70(9), pp. 1272-1275. (doi: 10.1107/S2053230X14017403)

Grinter, R., Milner, J. ORCID logoORCID: https://orcid.org/0000-0003-3702-4295 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2013) Beware of proteins bearing gifts: protein antibiotics that use iron as a Trojan horse. FEMS Microbiology Letters, 338(1), pp. 1-9. (doi: 10.1111/1574-6968.12011)

Dunne, K.A. et al. (2013) Increased S-nitrosylation and proteasomal degradation of caspase-3 during infection contribute to the persistence of adherent invasive escherichia coli (AIEC) in immune cells. PLoS ONE, 8(7), e68386. (doi: 10.1371/journal.pone.0068386) (PMID:23861899) (PMCID:PMC3701656)

Brown, Carla L., Smith, Karen, McCaughey, Laura ORCID logoORCID: https://orcid.org/0000-0001-5897-0163 and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2012) Colicin-like bacteriocins as novel therapeutic agents for the treatment of chronic biofilm-mediated infection. Biochemical Society Transactions, 40(6), pp. 1549-1552. (doi: 10.1042/BST20120241) (PMID:23176515)

Grinter, R., Milner, J. and Walker, D. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2012) Bacteriocins active against plant pathogenic bacteria. Biochemical Society Transactions, 40(6), pp. 1498-1502. (doi: 10.1042/BST20120206)

Penfold, C.N., Walker, D. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 and Kleanthous, C. (2012) How bugs kill bugs: progress and challenges in bacteriocin research. Biochemical Society Transactions, 40(6), pp. 1433-1437. (doi: 10.1042/BST20120253)

Grinter, R., Roszak, A.W., Cogdell, R.J. ORCID logoORCID: https://orcid.org/0000-0003-2119-6607, Milner, J.J. ORCID logoORCID: https://orcid.org/0000-0003-3702-4295 and Walker, D. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2012) The crystal structure of the lipid II-degrading bacteriocin syringacin M suggests unexpected evolutionary relationships between colicin M-like bacteriocins. Journal of Biological Chemistry, 287(46), pp. 38876-38888. (doi: 10.1074/jbc.M112.400150)

Smith, K., Martin, L., Rinaldi, A., Rajendran, R., Ramage, G. and Walker, D. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2012) Activity of Pyocin S2 against Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy, 56(3), pp. 1599-1601. (doi: 10.1128/AAC.05714-11)

Grinter, R., Milner, J. ORCID logoORCID: https://orcid.org/0000-0003-3702-4295 and Walker, D. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2012) Ferredoxin containing bacteriocins suggest a novel mechanism of iron uptake in Pectobacterium spp. PLoS ONE, 7(3), e33033. (doi: 10.1371/journal.pone.0033033) (PMID:22427936) (PMCID:PMC3302902)

Selkrig, J. et al. (2012) Discovery of an archetypal protein transport system in bacterial outer membranes. Nature Structural and Molecular Biology, 19(5), pp. 506-510. (doi: 10.1038/nsmb.2261)

Walker, D, Moshbahi, K, Vankemmelbeke, M, James, R and Kleanthous, C (2007) The role of electrostatics in colicin nuclease domain translocation into bacterial cells. Journal of Biological Chemistry, 282, pp. 31389-31397. (doi: 10.1074/jbc.M705883200)

Loftus, SR, Walker, D, Mate, MJ, Bonsor, DA, James, R, Moore, GR and Kleanthous, C (2006) Competitive recruitment of the periplasmic translocation portal TolB by a natively disordered domain of colicin E9. Proceedings of the National Academy of Sciences of the United States of America, 103(33), pp. 12353-12358. (doi: 10.1073/pnas.0603433103)

Mosbahi, K, Walker, D, James, R, Moore, GR and Kleanthous, C (2006) Global structural rearrangement of the cell penetrating ribonuclease colicin E3 on interaction with phospholipid membranes. Protein Science, 15, pp. 620-627. (doi: 10.1110/ps.051890306)

Mosbahi, K, Walker, D, Lea, E, Moore, GR, James, R and Kleanthous, C (2004) Destabilization of the colicin E9 endonuclease domain by interaction with negatively charged phospholipids - Implications for colicin translocation into bacteria. Journal of Biological Chemistry, 279, pp. 22145-22151. (doi: 10.1074/jbc.M400402200)

Walker, D, Lancaster, L, James, R and Kleanthous, C (2004) Identification of the catalytic motif of the microbial ribosome inactivating cytotoxin colicin E3. Protein Science, 13, pp. 1603-1611.

Walker, D, Rolfe, M, Thompson, A, Moore, GR, James, R, Hinton, JCD and Kleanthous, C (2004) Transcriptional profiling of colicin-induced cell death of Escherichia coli MG1655 identifies potential mechanisms by which bacteriocins promote bacterial diversity. Journal of Bacteriology, 186, pp. 866-869. (doi: 10.1128/JB.186.3.866-869.2004)

Law, Christopher J., Penfold, Christopher N., Walker, Daniel C. ORCID logoORCID: https://orcid.org/0000-0002-4206-2942, Moore, Geoffrey R., James, Richard and Kleanthous, Colin (2003) OmpF enhances the ability of BtuB to protect susceptible Escherichia coli cells from colicin E9 cytotoxicity. FEBS Letters, 545(2-3), pp. 127-132. (doi: 10.1016/S0014-5793(03)00511-8)

Walker, D, Moore, GR, James, R and Kleanthous, C (2003) Thermodynamic consequences of bipartite immunity protein binding to the ribosomal ribonuclease colicin E3. Biochemistry, 42, pp. 4161-4171. (doi: 10.1021/bi0273720)

McEwan, Alastair G., Lewin, Allison, Davy, Sharon L., Boetzel, Ruth, Leech, Andrew, Walker, Daniel, Wood, Tania and Moore, Geoffrey R. (2002) PrrC from Rhodobacter sphaeroides, a homologue of eukaryotic Sco proteins, is a copper-binding protein and may have a thiol-disulfide oxidoreductase activity. FEBS Letters, 518(1-3), pp. 10-16. (doi: 10.1016/S0014-5793(02)02532-2)

McAllen, R, Walker, D and Taylor, A (2002) The environmental effects of salinity and temperature on the oxygen consumption and total body osmolality of the marine flatworm Procerodes littoralis. Journal of Experimental Marine Biology and Ecology, 268, pp. 103-113.

Walker, DC, Georgiou, T, Pommer, AJ, Walker, D, Moore, GR, Kleanthous, C and James, R (2002) Mutagenic scan of the H-N-H motif of colicin E9: implications for the mechanistic enzymology of colicins, homing enzymes and apoptotic endonucleases. Nucleic Acids Research, 30, pp. 3225-3234.

Pommer, A.J. et al. (2001) Mechanism and cleavage specificity of the H-N-H endonuclease colicin E9. Journal of Molecular Biology, 314(4), pp. 735-749. (doi: 10.1006/jmbi.2001.5189)

Kleanthous, Colin and Walker, Daniel ORCID logoORCID: https://orcid.org/0000-0002-4206-2942 (2001) Immunity proteins: enzyme inhibitors that avoid the active site. Trends in Biochemical Sciences, 26(10), pp. 624-631. (doi: 10.1016/S0968-0004(01)01941-7) (PMID:11590016)

Patents

The University Court Of The University of Glasgow (2019) Bacterial pathogen derived resistance in plants. .

This list was generated on Sun Jun 15 14:13:06 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • A platform technology for engineering therapeutic protein antibiotics
    Medical Research Council
    2022 - 2023
     
  • Antimicrobial peptides as designer drugs
    Medical Research Council
    2022 - 2022
     
  • Exploiting bacteriocins for plant protection against pathogenic bacteria
    Biotechnology and Biological Sciences Research Council
    2019 - 2021
     
  • Targeted antibiotic therapy for highly drug-resistant lung infections in cystic fibrosis
    Tenovus Scotland
    2019 - 2020
     
  • Precision targeting of the gut microbiome for the treatment of Inflammatory Bowel Disease and Autoimmune diseases
    Scottish Enterprise
    2017 - 2019
     
  • Protein antibiotics for the treatment of Pseudomonas aeruginosa lung infection
    Medical Research Council
    2016 - 2019
     
  • Protein Antibiotics: Discovery, mode of action and development
    Wellcome Trust
    2016 - 2021
     
  • Precision targeting of the microbiome for the treatment of Crohn's disease
    Scottish Enterprise
    2016 - 2016
     
  • CiC Precision engineering of the human gut microbiome
    Medical Research Council
    2016 - 2018
     
  • Where and Why: The Influence of Host Metabolism on Bacterial Niche Specificity
    Biotechnology and Biological Sciences Research Council
    2016 - 2019
     
  • Bacteria Combat; educational & interactive microbiology app
    Society for Applied Microbiology
    2015 - 2015
     
  • A novel mechanism of protein uptake in Gram-negative bacteria
    Biotechnology and Biological Sciences Research Council
    2014 - 2018
     
  • Confidence in Concept: Species-specific antibiotics for the treatment of bacterial infections
    Medical Research Council
    2014 - 2015
     
  • Development of Colicins for the treatment of Crohn's disease.
    Tenovus Scotland
    2012 - 2013
     
  • Antimicrobial activity of S-type pyocins against Pseudomonas aeruginosa in the biofilm state
    Medical Research Scotland
    2009 - 2011
     
  • Role of YtfM in E.coli outer membrane assembly
    Biotechnology and Biological Sciences Research Council
    2009 - 2012
     
  • Antimicrobial activity of S-type pyocins against Pseudomonas aeruginosa in the biofilm state
    Tenovus Scotland
    2008 - 2009
     
  • Determining the kinetic mechanism and thermodynamic signature of binding induced protein folding
    The Royal Society
    2008 - 2009
     

Professional activities & recognition

Grant committees & research advisory boards

  • 2015: BBSRC, Member of the BBSRC Pool of Experts

Professor Daniel Walker on Twitter