Professor Andy Waters

  • Professor in Biomedical and Life Sciences (Parasitology)
  • Associate (School of Life Sciences)

telephone: 01413308720
email: Andy.Waters@glasgow.ac.uk

Room B515, Iii - Gbrc, University Place, Glasgow G12 8TA

ORCID iDhttps://orcid.org/0000-0001-8900-2982

Research interests

Prof Waters has >30 years experience in malaria research and together with Dr Chris Janse helped pioneer the development of the rodent model of malaria research, Plasmodium berghei in Leiden. He is a Wellcome Trust Principal Research Fellow with current funding until 2021. The major objective of the Glasgow laboratory is to understand the molecular developmental biology that is associated with sexual development.

There are three main themes to the research:

1. Triggers for gametocytogenesis. A transcription factor underpinning commitment to this critical event has been recently identified in the laboratory (Sinha et al (2014) Nature).  Its mode of action and control of its expression are currently under study.

2.  Influence of host environment on parasite development. This is an interest largely driven by metabolomics and seeks to understand the resources available to the intracellular parasite and the consequences of those resources for drug development and parasite maturation.

3. Development of tools for the more sophisticated genetic engineering of malaria parasites

The laboratory analyses these issues using a polyomics approach which is institutionalised in Glasgow and includes: metabolomics, NGS, proteomics, parasite genetic manipulation and complemented by a fully functioning insectary.  Technology development is also a key part of our activities where we have recently developed three new approaches to inducible regulation of gene/protein expression with a view to assigning function to genes/proteins

Our laboratory currently has four post-doctoral researchers with a great range of molecular biological expertise, four technical support staff and four PhD students.  Our activities are complemented by three other research groups working on malaria or Toxoplasma and through our participation in the WTCMP of which Prof Waters is Director.  Together with the many other parasitological groups at Glasgow there is the greatest concentration and breadth of molecular parasitology expertise in the UK. Prof. Waters was also Scientific Director of Evimalar, a European Commission-funded Network of Excellence that improved European and global collaboration in the basic research of malaria parasite biology and their interactions with their hosts and vectors.  Evimalar has now devolved to form Evimalar EEIG (European Economic Interest Group) which contains 13 founder members and can partner traditional institutions in bids for international funding.

 

Our Group:

PPDRAs and Fellows

Dr Nisha Philip has extensive experience in signalling and miRNAs in Plasmodium and has recently developed an inducible protein degradation systems (Philip & Waters, 2015)

Dr Katie Hughes has extensive experience in Plasmodium cell biology and protozoan molecular biology. 

Dr Brett Roberts has just joined the laboratory and will focus on parasite genetic manipulation.

Dr Sebastian Kirchner is a Marie Curie International Fellow studying epigenetic regulation of Plasmodium gene expression.

PhD students: thesis titles.

Ms Rebecca Lee: “The Natural History of Plasmodium Gametocytes”

Ms Robyn Kent: “Experimentally Inducible Gametocytogenesis in Plasmodium”

Ms Joanne Power; “ Epigenetics and Gametocytogenesis in Plasmodium”

There is currently a vacancy for an experienced bioinformatician.

The Tech Team

Ms Anne Graham is the Laboratory Manager and responsible for the co-ordination of the laboratory activities.  She has extensive experience in molecular biology.

Ms Heli Vaikinnen has extensive experience in the molecular biology of protozoan parasites.

Mrs Angela McBride runs the group’s insectary facility Mr John Archer has expertise in informatics and parasitology

Updated: 4.11.2015

Publications

List by: Type | Date

Jump to: 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008
Number of items: 70.

2021

Simwela, N., Hughes, K. R., Rennie, M. T., Barrett, M. P. and Waters, A. P. (2021) Mammalian deubiquitinating enzyme inhibitors display. ACS Infectious Diseases, 7(2), pp. 333-346. (doi: 10.1021/acsinfecdis.0c00580) (PMID:33400499)

2020

Simwela, N., Stokes, B. H., Aghabi, D., Bogyo, M., Fidock, D. A. and Waters, A. (2020) Plasmodium berghei K13 mutations mediate in vivo artemisinin resistance that is reversed by proteasome inhibition. mBio, 11, e02312-20. (doi: 10.1128/mBio.02312-20) (PMID:33173001) (PMCID:PMC7667033)

Simwela, N., Hughes, K. R., Roberts, A. B., Rennie, M. T., Barrett, M. P. and Waters, A. P. (2020) Experimentally engineered mutations in a ubiquitin hydrolase, UBP-1, modulate in vivo susceptibility to artemisinin and chloroquine in Plasmodium berghei. Antimicrobial Agents and Chemotherapy, 64(7), (doi: 10.1128/AAC.02484-19) (PMID:32340987) (PMCID:PMC7318008)

Patil, H., Hughes, K. R., Lemgruber Soares, L. , Philip, N., Dickens, N. , Starnes, G. L. and Waters, A. P. (2020) Zygote morphogenesis but not the establishment of cell polarity in Plasmodium berghei is controlled by the small GTPase, RAB11A. PLoS Pathogens, 16(5), e1008091. (doi: 10.1371/journal.ppat.1008091) (PMID:32463831) (PMCID:PMC7255598)

2019

Alam, M. M. et al. (2019) Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science, 365(6456), eaau1682. (doi: 10.1126/science.aau1682) (PMID:31467193)

Kirchner, S. and Waters, A. P. (2019) Coalition politics: linking malaria transmission to mosquito reproduction. Trends in Parasitology, 35(7), pp. 486-489. (doi: 10.1016/j.pt.2019.05.003) (PMID:31138514)

2018

Kent, R. S., Modrzynska, K. K. , Cameron, R., Philip, N., Billker, O. and Waters, A. P. (2018) Inducible developmental reprogramming redefines commitment to sexual development by malaria parasites. Nature Microbiology, 3(11), pp. 1206-1213. (doi: 10.1038/s41564-018-0223-6) (PMID:30177743) (PMCID:PMC6317699)

De Niz, M. et al. (2018) Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow. Science Advances, 4(5), eaat3775. (doi: 10.1126/sciadv.aat3775) (PMID:29806032) (PMCID:PMC5966192)

Lee, R. S., Waters, A. P. and Brewer, J. M. (2018) A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy. Nature Communications, 9, 1689. (doi: 10.1038/s41467-018-04108-9) (PMID:29703959) (PMCID:PMC5924373)

2017

Brancucci, N. M.B. et al. (2017) Lysophosphatidylcholine regulates sexual Stage differentiation in the human malaria parasite Plasmodium falciparum. Cell, 171(7), 1532-1544.e15. (doi: 10.1016/j.cell.2017.10.020) (PMID:29129376) (PMCID:PMC5733390)

Waters, A.P. and Bechtsi, D.P. (2017) Genomics and epigenetics of sexual commitment in Plasmodium. International Journal for Parasitology, 47(7), pp. 425-434. (doi: 10.1016/j.ijpara.2017.03.002) (PMID:28455236)

Hughes, K. R. and Waters, A. P. (2017) Rapid inducible protein displacement in Plasmodium in vivo and in vitro using knocksideways technology. Wellcome Open Research, 2, 18. (doi: 10.12688/wellcomeopenres.11005.1) (PMID:28428983) (PMCID:PMC5395084)

2016

Srivastava, A., Philip, N., Hughes, K. R., Georgiou, K., MacRae, J. I., Barrett, M. P. , Creek, D. J., McConville, M. J. and Waters, A. P. (2016) Stage-specific changes in plasmodium metabolism required for differentiation and adaptation to different host and vector environments. PLoS Pathogens, 12(12), e1006094. (doi: 10.1371/journal.ppat.1006094) (PMID:28027318) (PMCID:PMC5189940)

Kirchner, S. , Power, B. J. and Waters, A. P. (2016) Recent advances in malaria genomics and epigenomics. Genome Medicine, 8, 92. (doi: 10.1186/s13073-016-0343-7) (PMID:27605022) (PMCID:PMC5015228)

Fairlamb, A. H., Gow, N. A.R., Matthews, K. R. and Waters, A. P. (2016) Drug resistance in eukaryotic microorganisms. Nature Microbiology, 1(7), 16092. (doi: 10.1038/nmicrobiol.2016.92) (PMID:27572976) (PMCID:PMC5215055)

Kenthirapalan, S., Waters, A. P. , Matuschewski, K. and Kooij, T. W. A. (2016) Functional profiles of orphan membrane transporters in the life cycle of the malaria parasite. Nature Communications, 7, 10519. (doi: 10.1038/ncomms10519) (PMID:26796412) (PMCID:PMC4736113)

Waters, A. (2016) Epigenetic roulette in blood stream plasmodium: gambling on sex. PLoS Pathogens, 12(2), e1005353. (doi: 10.1371/journal.ppat.1005353) (PMID:26866803) (PMCID:PMC4750958)

2015

Philip, N. and Waters, A. P. (2015) Conditional degradation of plasmodium calcineurin reveals functions in parasite colonization of both host and vector. Cell Host and Microbe, 18(1), pp. 122-131. (doi: 10.1016/j.chom.2015.05.018) (PMID:26118994) (PMCID:PMC4509507)

Srivastava, A., Creek, D. J., Evans, K. J., De Souza, D., Schofield, L., Muller, S., Barrett, M. P. , McConville, M. J. and Waters, A. P. (2015) Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites. PLoS Pathogens, 11(6), e1004882. (doi: 10.1371/journal.ppat.1004882) (PMID:26042734) (PMCID:PMC4456406)

Tampaki, Z., Mwakubambanya, R. S., Goulielmaki, E., Kaforou, S., Kim, K., Waters, A. P. , Carruthers, V. B., Siden-Kiamos, I., Loukeris, T. G. and Koussis, K. (2015) Ectopic expression of a Neospora caninum Kazal type inhibitor triggers developmental defects in Toxoplasma and Plasmodium. PLoS ONE, 10(3), e0121379. (doi: 10.1371/journal.pone.0121379) (PMID:25803874) (PMCID:PMC4372514)

2014

Otto, T. D. et al. (2014) A comprehensive evaluation of rodent malaria parasite genomes and gene expression. BMC Biology, 12(1), p. 86. (doi: 10.1186/s12915-014-0086-0) (PMID:25359557) (PMCID:PMC4242472)

Religa, A., Ramesar, J., Janse, C. J., Scherf, A. and Waters, A. P. (2014) P. berghei telomerase subunit TERT is essential for parasite survival. PLoS ONE, 9(10), e108930. (doi: 10.1371/journal.pone.0108930) (PMID:25275500) (PMCID:PMC4183507)

Frischknecht, F., Mota, M., Scherf, A. and Waters, A. (2014) Biology of the Malaria Parasite - editorial on the special issue for the 10th BioMalPar conference. Cellular Microbiology, 16(5), pp. 599-601. (doi: 10.1111/cmi.12295)

Sinha, A. et al. (2014) A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium. Nature, 507(7491), pp. 253-257. (doi: 10.1038/nature12970) (PMID:24572359) (PMCID:PMC4105895)

Kenthirapalan, S., Waters, A. P. , Matuschewski, K. and Kooij, T. W. A. (2014) Copper-transporting ATPase is important for malaria parasite fertility. Molecular Microbiology, 91(2), pp. 315-325. (doi: 10.1111/mmi.12461)

2013

Philip, N. and Waters, A. P. (2013) Unveiling the malaria parasite's cloak of invisibility? Science, 340(6135), pp. 936-937. (doi: 10.1126/science.1239146)

Lin, J.-W. et al. (2013) Loss-of-function analyses defines vital and redundant functions of the plasmodiumrhomboid protease family. Molecular Microbiology, 88(2), pp. 318-338. (doi: 10.1111/mmi.12187)

Philip, N., Orr, R. and Waters, A.P. (2013) Transfection of rodent malaria parasites. Methods in Molecular Biology, 923, pp. 99-125.

Waters, A.P. (2013) EVIMalaR — a model for international cooperation in scientific research. Nature Reviews Microbiology, 11(8), pp. 505-506. (doi: 10.1038/nrmicro3079)

2012

Kenthirapalan, S., Waters, A.P. , Matuschewski, K. and Kooij, T.W. (2012) Flow cytometry-assisted rapid isolation of recombinant Plasmodium berghei parasites exemplified by functional analysis of aquaglyceroporin. International Journal for Parasitology, 42(13-14), pp. 1185-1192. (doi: 10.1016/j.ijpara.2012.10.006)

Religa, A.A. and Waters, A.P. (2012) Sirtuins of parasitic protozoa: in search of function(s). Molecular and Biochemical Parasitology, 185(2), pp. 71-88. (doi: 10.1016/j.molbiopara.2012.08.003)

Reboud, J. , Bourquin, Y., Wilson, R. , Pall, G.S., Jiwaji, M., Pitt, A.R., Graham, A., Waters, A.P. and Cooper, J.M. (2012) Shaping acoustic fields as a toolset for microfluidic manipulations in diagnostic technologies. Proceedings of the National Academy of Sciences of the United States of America, 109(38), pp. 15162-15167. (doi: 10.1073/pnas.1206055109)

Crabb, B. S., Beeson, J. G., Amino, R., Ménard, R., Waters, A. , Winzeler, E. A., Wahlgren, M., Fidock, D. A. and Nwaka, S. (2012) Perspectives: the missing pieces. Nature, 484(7395), S22-S23. (doi: 10.1038/484S22a)

Khan, S. M., Reece, S. E., Waters, A. P. , Janse, C. J. and Kaczanowski, S. (2012) Why are male malaria parasites in such a rush?: Sex-specific evolution and host-parasite interactions. Evolution, Medicine, and Public Health, 2013(1), pp. 3-13. (doi: 10.1093/emph/eos003) (PMID:24481180) (PMCID:PMC4183958)

Orr, R.Y., Philip, N. and Waters, A.P. (2012) Improved negative selection protocol for Plasmodium berghei in the rodent malarial model. Malaria Journal, 11(103), (doi: 10.1186/1475-2875-11-103)

Philip, N., Vaikkinen, H.J., Tetley, L. and Waters, A.P. (2012) A unique kelch domain phosphatase in plasmodium regulates ookinete morphology, motility and invasion. PLoS ONE, 7(9), e44617. (doi: 10.1371/journal.pone.0044617)

Ramakrishnan, C., Rademacher, A., Soichot, J., Costa, G., Waters, A.P. , Janse, C.J., Ramesar, J., Franke-Fayard, B.M. and Levashina, E.A. (2012) Salivary gland-specific P. berghei reporter lines enable rapid evaluation of tissue-specific sporozoite loads in mosquitoes. PLoS ONE, 7(5), e36376. (doi: 10.1371/journal.pone.0036376)

2011

Laurentino, E.C. et al. (2011) Experimentally controlled downregulation of the histone chaperone FACT in Plasmodium berghei reveals that it is critical to male gamete fertility. Cellular Microbiology, 13(12), pp. 1956-1974. (doi: 10.1111/j.1462-5822.2011.01683.x)

Fonager, J., Franke-Fayard, B.M.D., Adams, J.H., Ramesar, J., Klop, O., Khan, S.M., Janse, C.J. and Waters, A.P. (2011) Development of the piggyBac transposable system for Plasmodium berghei and its application for random mutagenesis in malaria parasites. BMC Genomics, 12(155), pp. 1-17. (doi: 10.1186/1471-2164-12-155)

Gomes-Santos, C.S.S. et al. (2011) Transition of plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein pumilio. PLoS Pathogens, 7(5), e1002046. (doi: 10.1371/journal.ppat.1002046)

Hills, T., Srivastava, A., Ayi, K., Wernimont, A.K., Kain, K., Waters, A.P. , Hui, R. and Pizarro, J.C. (2011) Characterization of a new phosphatase from Plasmodium. Molecular and Biochemical Parasitology, 179(2), pp. 69-79. (doi: 10.1016/j.molbiopara.2011.06.001)

Sicard, A. et al. (2011) Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes. Cellular Microbiology, 13(6), pp. 836-845. (doi: 10.1111/j.1462-5822.2011.01582.x)

Wykes, M.N. et al. (2011) Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice. Proceedings of the National Academy of Sciences of the United States of America, 108(27), pp. 11205-11210. (doi: 10.1073/pnas.1108579108)

2010

Hughes, K.R., Philip, N., Lucas Starnes, G., Taylor, S. and Waters, A.P. (2010) From cradle to grave: RNA biology in malaria parasites. Wiley Interdisciplinary Reviews: RNA, 1(2), pp. 287-303. (doi: 10.1002/wrna.30)

van Dijk, M.R. et al. (2010) Three members of the 6-cys protein family of Plasmodium play a role in gamete fertility. PLoS Pathogens, 6(6), e1000853. (doi: 10.1371/journal.ppat.1000853)

Iwanaga, S., Khan, S.M., Kaneko, I., Christodoulou, Z., Newbold, C.N., Yuda, M., Janse, C.J. and Waters, A.P. (2010) Functional identification of the Plasmodium centromere and generation of a Plasmodium artificial chromosome. Cell Host and Microbe, 7(3), pp. 245-255. (doi: 10.1016/j.chom.2010.02.010)

Starnes, G. L. and Waters, A.P. (2010) Home improvements: how the malaria parasite makes the red blood cell home sweet home. Journal of Molecular Cell Biology, 2(1), pp. 11-13. (doi: 10.1093/jmcb/mjp024)

Bopp, S.E.R. et al. (2010) Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-γ as contributing to enhanced malaria surviva. PLoS ONE, 5(5), e10903. (doi: 10.1371/journal.pone.0010903)

Goldberg, D. E., Janse, C.J., Cowman, A. F. and Waters, A.P. (2010) Has the time come for us to complement our malaria parasites? Trends in Parasitology, 27(1), pp. 1-2. (doi: 10.1016/j.pt.2010.06.017)

Janse, C.J., Kroeze, H., van Wigcheren, A., Mededovic, S., Fonager, J., Franke-Fayard, B., Waters, A.P. and Khan, S.H. (2010) A genotype and phenotype database of genetically modified malaria-parasites. Trends in Parasitology, 27(1), pp. 31-39. (doi: 10.1016/j.pt.2010.06.016)

Mair, G.R. et al. (2010) Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development. PLoS Pathogens, 6(2), e1000767. (doi: 10.1371/journal.ppat.1000767)

Ploemen, I.H.J. et al. (2010) Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging. PLoS ONE, 4(11), e7881. (doi: 10.1371/journal.pone.0007881)

Spaccapelo, R. et al. (2010) Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria. American Journal of Pathology, 176(1), pp. 205-217. (doi: 10.2353/ajpath.2010.090504)

2009

Ponzi, M. et al. (2009) Egress of Plasmodium berghei gametes from their host erythrocyte is mediated by the MDV-1/PEG3 protein. Cellular Microbiology, 11(8), pp. 1272-1288. (doi: 10.1111/j.1462-5822.2009.01331.x)

Tufet-Bayona, M., Janse, C.J., Khan, S.M., Waters, A.P. , Sinden, R.E. and Franke-Fayard, B. (2009) Localisation and timing of expression of putative Plasmodium berghei rhoptry proteins in merozoites and sporozoites. Molecular and Biochemical Parasitology, 166(1), pp. 22-31. (doi: 10.1016/j.molbiopara.2009.02.009)

Vega-Rodriguez, J., Franke-Fayard, B., Dinglasan, R.R., Janse, C.J., Pastrana-Mena, R., Rodriguez-Orengo, J.F., Jacobs-Lorena, M., Serrano, A.E., Waters, A. and Srinivasan, P. (2009) The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission. PLoS Pathogens, 5(2), e1000302. (doi: 10.1371/journal.ppat.1000302)

Baum, J., Papenfuss, A.T., Mair, G.R., Janse, C.J., Vlachou, D., Waters, A.P. , Cowman, A.F., Crabb, B.S. and Koning-Ward, T.F. (2009) Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites. Nucleic Acids Research, 37(11), pp. 3788-3798. (doi: 10.1093/nar/gkp239)

Dobson, S. E., Augustijn, K. D., Brannigan, J. A., Schnick, C., Janse, C. J., Dodson, E. J., Waters, A.P. and Wilkinson, A. J. (2009) The crystal structures of macrophage migration inhibitory factor fromPlasmodium falciparumandPlasmodium berghei. Protein Science, 18(12), pp. 2578-2591. (doi: 10.1002/pro.263)

Lavazec, C., Moreira, C.K., Mair, G.R., Waters, A.P. , Janse, C.J. and Templeton, T.J. (2009) Analysis of mutant Plasmodium berghei parasites lacking expression of multiple PbCCp genes. Molecular and Biochemical Parasitology, 163(1), pp. 1-7. (doi: 10.1016/j.molbiopara.2008.09.002)

Moon, R.W., Taylor, C.J., Bex, C., Schepers, R., Goulding, D., Janse, C.J., Waters, A.P., Baker, D.A. and Billker, O. (2009) A cyclic GMP signalling module that regulates gliding motility in a malaria parasite. PLoS Pathogens, 5(9), e1000599. (doi: 10.1371/journal.ppat.1000599)

Yuda, M., Iwanaga, S., Shigenobu, S., Mair, G.R., Janse, C.J., Waters, A.P. , Kato, T. and Kaneko, I. (2009) Identification of a transcription factor in the mosquito-invasive stage of malaria parasites. Molecular Microbiology, 71(6), pp. 1402-1414. (doi: 10.1111/j.1365-2958.2009.06609.x)

2008

Yu, M. et al. (2008) The fatty acid biosynthesis enzyme fabi plays a key role in the development of liver stage malarial parasites. Cell Host and Microbe, 4(6), pp. 567-568. (doi: 10.1016/j.chom.2008.11.001)

van Schaijk, B. C. L. et al. (2008) Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes. PLoS ONE, 3(10), e3549. (doi: 10.1371/journal.pone.0003549)

Braks, J.A.M., Mair, G.R., Franke-Fayard, B., Janse, C.J. and Waters, A.P. (2008) A conserved U-rich RNA region implicated in regulation of translation in Plasmodium female gametocytes. Nucleic Acids Research, 36(4), pp. 1176-1186. (doi: 10.1093/nar/gkm1142)

Di Girolamo, F. et al. (2008) Plasmodium lipid rafts contain proteins implicated in vesicular trafficking and signalling as well as members of the PIR superfamily, potentially implicated in host immune system interactions. Proteomics, 8(12), pp. 2500-2513. (doi: 10.1002/pmic.200700763)

Franke-Fayard, B., Djokovic, D., Dooren, M.W., Ramesar, J., Waters, A.P. , Falade, M.O., Kranendonk, M., Martinelli, A., Cravo, P. and Janse, C.J. (2008) Simple and sensitive antimalarial drug screening in vitro and in vivo using transgenic luciferase expressing Plasmodium berghei parasites. International Journal for Parasitology, 38(14), pp. 1651-1662. (doi: 10.1016/j.ijpara.2008.05.012)

Lasonder, E. et al. (2008) Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity. PLoS Pathogens, 4(10), e1000195. (doi: 10.1371/journal.ppat.1000195)

Moreira, C.K., Templeton, T.J., Lavazec, C., Hayward, R.E., Hobbs, C.V., Kroeze, H., Janse, C.J., Waters, A.P. , Sinnis, P. and Coppi, A. (2008) The Plasmodium TRAPMIC2 family member, TRAP-Like Protein (TLP), is involved in tissue traversal by sporozoites. Cellular Microbiology, 10(7), pp. 1505-1516. (doi: 10.1111/j.1462-5822.2008.01143.x)

van Ooij, C. et al. (2008) The malaria secretome: from algorithms to essential function in blood stage infection. PLoS Pathogens, 4(6), e1000084. (doi: 10.1371/journal.ppat.1000084)

Waters, A.P. (2008) Genome-informed contributions to malaria therapies: feeding somewhere down the (pipe)line. Cell Host and Microbe, 3(5), pp. 280-283. (doi: 10.1016/j.chom.2008.04.005)

This list was generated on Fri Oct 15 16:20:07 2021 BST.
Jump to: Articles
Number of items: 70.

Articles

Simwela, N., Hughes, K. R., Rennie, M. T., Barrett, M. P. and Waters, A. P. (2021) Mammalian deubiquitinating enzyme inhibitors display. ACS Infectious Diseases, 7(2), pp. 333-346. (doi: 10.1021/acsinfecdis.0c00580) (PMID:33400499)

Simwela, N., Stokes, B. H., Aghabi, D., Bogyo, M., Fidock, D. A. and Waters, A. (2020) Plasmodium berghei K13 mutations mediate in vivo artemisinin resistance that is reversed by proteasome inhibition. mBio, 11, e02312-20. (doi: 10.1128/mBio.02312-20) (PMID:33173001) (PMCID:PMC7667033)

Simwela, N., Hughes, K. R., Roberts, A. B., Rennie, M. T., Barrett, M. P. and Waters, A. P. (2020) Experimentally engineered mutations in a ubiquitin hydrolase, UBP-1, modulate in vivo susceptibility to artemisinin and chloroquine in Plasmodium berghei. Antimicrobial Agents and Chemotherapy, 64(7), (doi: 10.1128/AAC.02484-19) (PMID:32340987) (PMCID:PMC7318008)

Patil, H., Hughes, K. R., Lemgruber Soares, L. , Philip, N., Dickens, N. , Starnes, G. L. and Waters, A. P. (2020) Zygote morphogenesis but not the establishment of cell polarity in Plasmodium berghei is controlled by the small GTPase, RAB11A. PLoS Pathogens, 16(5), e1008091. (doi: 10.1371/journal.ppat.1008091) (PMID:32463831) (PMCID:PMC7255598)

Alam, M. M. et al. (2019) Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science, 365(6456), eaau1682. (doi: 10.1126/science.aau1682) (PMID:31467193)

Kirchner, S. and Waters, A. P. (2019) Coalition politics: linking malaria transmission to mosquito reproduction. Trends in Parasitology, 35(7), pp. 486-489. (doi: 10.1016/j.pt.2019.05.003) (PMID:31138514)

Kent, R. S., Modrzynska, K. K. , Cameron, R., Philip, N., Billker, O. and Waters, A. P. (2018) Inducible developmental reprogramming redefines commitment to sexual development by malaria parasites. Nature Microbiology, 3(11), pp. 1206-1213. (doi: 10.1038/s41564-018-0223-6) (PMID:30177743) (PMCID:PMC6317699)

De Niz, M. et al. (2018) Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow. Science Advances, 4(5), eaat3775. (doi: 10.1126/sciadv.aat3775) (PMID:29806032) (PMCID:PMC5966192)

Lee, R. S., Waters, A. P. and Brewer, J. M. (2018) A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy. Nature Communications, 9, 1689. (doi: 10.1038/s41467-018-04108-9) (PMID:29703959) (PMCID:PMC5924373)

Brancucci, N. M.B. et al. (2017) Lysophosphatidylcholine regulates sexual Stage differentiation in the human malaria parasite Plasmodium falciparum. Cell, 171(7), 1532-1544.e15. (doi: 10.1016/j.cell.2017.10.020) (PMID:29129376) (PMCID:PMC5733390)

Waters, A.P. and Bechtsi, D.P. (2017) Genomics and epigenetics of sexual commitment in Plasmodium. International Journal for Parasitology, 47(7), pp. 425-434. (doi: 10.1016/j.ijpara.2017.03.002) (PMID:28455236)

Hughes, K. R. and Waters, A. P. (2017) Rapid inducible protein displacement in Plasmodium in vivo and in vitro using knocksideways technology. Wellcome Open Research, 2, 18. (doi: 10.12688/wellcomeopenres.11005.1) (PMID:28428983) (PMCID:PMC5395084)

Srivastava, A., Philip, N., Hughes, K. R., Georgiou, K., MacRae, J. I., Barrett, M. P. , Creek, D. J., McConville, M. J. and Waters, A. P. (2016) Stage-specific changes in plasmodium metabolism required for differentiation and adaptation to different host and vector environments. PLoS Pathogens, 12(12), e1006094. (doi: 10.1371/journal.ppat.1006094) (PMID:28027318) (PMCID:PMC5189940)

Kirchner, S. , Power, B. J. and Waters, A. P. (2016) Recent advances in malaria genomics and epigenomics. Genome Medicine, 8, 92. (doi: 10.1186/s13073-016-0343-7) (PMID:27605022) (PMCID:PMC5015228)

Fairlamb, A. H., Gow, N. A.R., Matthews, K. R. and Waters, A. P. (2016) Drug resistance in eukaryotic microorganisms. Nature Microbiology, 1(7), 16092. (doi: 10.1038/nmicrobiol.2016.92) (PMID:27572976) (PMCID:PMC5215055)

Kenthirapalan, S., Waters, A. P. , Matuschewski, K. and Kooij, T. W. A. (2016) Functional profiles of orphan membrane transporters in the life cycle of the malaria parasite. Nature Communications, 7, 10519. (doi: 10.1038/ncomms10519) (PMID:26796412) (PMCID:PMC4736113)

Waters, A. (2016) Epigenetic roulette in blood stream plasmodium: gambling on sex. PLoS Pathogens, 12(2), e1005353. (doi: 10.1371/journal.ppat.1005353) (PMID:26866803) (PMCID:PMC4750958)

Philip, N. and Waters, A. P. (2015) Conditional degradation of plasmodium calcineurin reveals functions in parasite colonization of both host and vector. Cell Host and Microbe, 18(1), pp. 122-131. (doi: 10.1016/j.chom.2015.05.018) (PMID:26118994) (PMCID:PMC4509507)

Srivastava, A., Creek, D. J., Evans, K. J., De Souza, D., Schofield, L., Muller, S., Barrett, M. P. , McConville, M. J. and Waters, A. P. (2015) Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites. PLoS Pathogens, 11(6), e1004882. (doi: 10.1371/journal.ppat.1004882) (PMID:26042734) (PMCID:PMC4456406)

Tampaki, Z., Mwakubambanya, R. S., Goulielmaki, E., Kaforou, S., Kim, K., Waters, A. P. , Carruthers, V. B., Siden-Kiamos, I., Loukeris, T. G. and Koussis, K. (2015) Ectopic expression of a Neospora caninum Kazal type inhibitor triggers developmental defects in Toxoplasma and Plasmodium. PLoS ONE, 10(3), e0121379. (doi: 10.1371/journal.pone.0121379) (PMID:25803874) (PMCID:PMC4372514)

Otto, T. D. et al. (2014) A comprehensive evaluation of rodent malaria parasite genomes and gene expression. BMC Biology, 12(1), p. 86. (doi: 10.1186/s12915-014-0086-0) (PMID:25359557) (PMCID:PMC4242472)

Religa, A., Ramesar, J., Janse, C. J., Scherf, A. and Waters, A. P. (2014) P. berghei telomerase subunit TERT is essential for parasite survival. PLoS ONE, 9(10), e108930. (doi: 10.1371/journal.pone.0108930) (PMID:25275500) (PMCID:PMC4183507)

Frischknecht, F., Mota, M., Scherf, A. and Waters, A. (2014) Biology of the Malaria Parasite - editorial on the special issue for the 10th BioMalPar conference. Cellular Microbiology, 16(5), pp. 599-601. (doi: 10.1111/cmi.12295)

Sinha, A. et al. (2014) A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium. Nature, 507(7491), pp. 253-257. (doi: 10.1038/nature12970) (PMID:24572359) (PMCID:PMC4105895)

Kenthirapalan, S., Waters, A. P. , Matuschewski, K. and Kooij, T. W. A. (2014) Copper-transporting ATPase is important for malaria parasite fertility. Molecular Microbiology, 91(2), pp. 315-325. (doi: 10.1111/mmi.12461)

Philip, N. and Waters, A. P. (2013) Unveiling the malaria parasite's cloak of invisibility? Science, 340(6135), pp. 936-937. (doi: 10.1126/science.1239146)

Lin, J.-W. et al. (2013) Loss-of-function analyses defines vital and redundant functions of the plasmodiumrhomboid protease family. Molecular Microbiology, 88(2), pp. 318-338. (doi: 10.1111/mmi.12187)

Philip, N., Orr, R. and Waters, A.P. (2013) Transfection of rodent malaria parasites. Methods in Molecular Biology, 923, pp. 99-125.

Waters, A.P. (2013) EVIMalaR — a model for international cooperation in scientific research. Nature Reviews Microbiology, 11(8), pp. 505-506. (doi: 10.1038/nrmicro3079)

Kenthirapalan, S., Waters, A.P. , Matuschewski, K. and Kooij, T.W. (2012) Flow cytometry-assisted rapid isolation of recombinant Plasmodium berghei parasites exemplified by functional analysis of aquaglyceroporin. International Journal for Parasitology, 42(13-14), pp. 1185-1192. (doi: 10.1016/j.ijpara.2012.10.006)

Religa, A.A. and Waters, A.P. (2012) Sirtuins of parasitic protozoa: in search of function(s). Molecular and Biochemical Parasitology, 185(2), pp. 71-88. (doi: 10.1016/j.molbiopara.2012.08.003)

Reboud, J. , Bourquin, Y., Wilson, R. , Pall, G.S., Jiwaji, M., Pitt, A.R., Graham, A., Waters, A.P. and Cooper, J.M. (2012) Shaping acoustic fields as a toolset for microfluidic manipulations in diagnostic technologies. Proceedings of the National Academy of Sciences of the United States of America, 109(38), pp. 15162-15167. (doi: 10.1073/pnas.1206055109)

Crabb, B. S., Beeson, J. G., Amino, R., Ménard, R., Waters, A. , Winzeler, E. A., Wahlgren, M., Fidock, D. A. and Nwaka, S. (2012) Perspectives: the missing pieces. Nature, 484(7395), S22-S23. (doi: 10.1038/484S22a)

Khan, S. M., Reece, S. E., Waters, A. P. , Janse, C. J. and Kaczanowski, S. (2012) Why are male malaria parasites in such a rush?: Sex-specific evolution and host-parasite interactions. Evolution, Medicine, and Public Health, 2013(1), pp. 3-13. (doi: 10.1093/emph/eos003) (PMID:24481180) (PMCID:PMC4183958)

Orr, R.Y., Philip, N. and Waters, A.P. (2012) Improved negative selection protocol for Plasmodium berghei in the rodent malarial model. Malaria Journal, 11(103), (doi: 10.1186/1475-2875-11-103)

Philip, N., Vaikkinen, H.J., Tetley, L. and Waters, A.P. (2012) A unique kelch domain phosphatase in plasmodium regulates ookinete morphology, motility and invasion. PLoS ONE, 7(9), e44617. (doi: 10.1371/journal.pone.0044617)

Ramakrishnan, C., Rademacher, A., Soichot, J., Costa, G., Waters, A.P. , Janse, C.J., Ramesar, J., Franke-Fayard, B.M. and Levashina, E.A. (2012) Salivary gland-specific P. berghei reporter lines enable rapid evaluation of tissue-specific sporozoite loads in mosquitoes. PLoS ONE, 7(5), e36376. (doi: 10.1371/journal.pone.0036376)

Laurentino, E.C. et al. (2011) Experimentally controlled downregulation of the histone chaperone FACT in Plasmodium berghei reveals that it is critical to male gamete fertility. Cellular Microbiology, 13(12), pp. 1956-1974. (doi: 10.1111/j.1462-5822.2011.01683.x)

Fonager, J., Franke-Fayard, B.M.D., Adams, J.H., Ramesar, J., Klop, O., Khan, S.M., Janse, C.J. and Waters, A.P. (2011) Development of the piggyBac transposable system for Plasmodium berghei and its application for random mutagenesis in malaria parasites. BMC Genomics, 12(155), pp. 1-17. (doi: 10.1186/1471-2164-12-155)

Gomes-Santos, C.S.S. et al. (2011) Transition of plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein pumilio. PLoS Pathogens, 7(5), e1002046. (doi: 10.1371/journal.ppat.1002046)

Hills, T., Srivastava, A., Ayi, K., Wernimont, A.K., Kain, K., Waters, A.P. , Hui, R. and Pizarro, J.C. (2011) Characterization of a new phosphatase from Plasmodium. Molecular and Biochemical Parasitology, 179(2), pp. 69-79. (doi: 10.1016/j.molbiopara.2011.06.001)

Sicard, A. et al. (2011) Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes. Cellular Microbiology, 13(6), pp. 836-845. (doi: 10.1111/j.1462-5822.2011.01582.x)

Wykes, M.N. et al. (2011) Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice. Proceedings of the National Academy of Sciences of the United States of America, 108(27), pp. 11205-11210. (doi: 10.1073/pnas.1108579108)

Hughes, K.R., Philip, N., Lucas Starnes, G., Taylor, S. and Waters, A.P. (2010) From cradle to grave: RNA biology in malaria parasites. Wiley Interdisciplinary Reviews: RNA, 1(2), pp. 287-303. (doi: 10.1002/wrna.30)

van Dijk, M.R. et al. (2010) Three members of the 6-cys protein family of Plasmodium play a role in gamete fertility. PLoS Pathogens, 6(6), e1000853. (doi: 10.1371/journal.ppat.1000853)

Iwanaga, S., Khan, S.M., Kaneko, I., Christodoulou, Z., Newbold, C.N., Yuda, M., Janse, C.J. and Waters, A.P. (2010) Functional identification of the Plasmodium centromere and generation of a Plasmodium artificial chromosome. Cell Host and Microbe, 7(3), pp. 245-255. (doi: 10.1016/j.chom.2010.02.010)

Starnes, G. L. and Waters, A.P. (2010) Home improvements: how the malaria parasite makes the red blood cell home sweet home. Journal of Molecular Cell Biology, 2(1), pp. 11-13. (doi: 10.1093/jmcb/mjp024)

Bopp, S.E.R. et al. (2010) Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-γ as contributing to enhanced malaria surviva. PLoS ONE, 5(5), e10903. (doi: 10.1371/journal.pone.0010903)

Goldberg, D. E., Janse, C.J., Cowman, A. F. and Waters, A.P. (2010) Has the time come for us to complement our malaria parasites? Trends in Parasitology, 27(1), pp. 1-2. (doi: 10.1016/j.pt.2010.06.017)

Janse, C.J., Kroeze, H., van Wigcheren, A., Mededovic, S., Fonager, J., Franke-Fayard, B., Waters, A.P. and Khan, S.H. (2010) A genotype and phenotype database of genetically modified malaria-parasites. Trends in Parasitology, 27(1), pp. 31-39. (doi: 10.1016/j.pt.2010.06.016)

Mair, G.R. et al. (2010) Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development. PLoS Pathogens, 6(2), e1000767. (doi: 10.1371/journal.ppat.1000767)

Ploemen, I.H.J. et al. (2010) Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging. PLoS ONE, 4(11), e7881. (doi: 10.1371/journal.pone.0007881)

Spaccapelo, R. et al. (2010) Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria. American Journal of Pathology, 176(1), pp. 205-217. (doi: 10.2353/ajpath.2010.090504)

Ponzi, M. et al. (2009) Egress of Plasmodium berghei gametes from their host erythrocyte is mediated by the MDV-1/PEG3 protein. Cellular Microbiology, 11(8), pp. 1272-1288. (doi: 10.1111/j.1462-5822.2009.01331.x)

Tufet-Bayona, M., Janse, C.J., Khan, S.M., Waters, A.P. , Sinden, R.E. and Franke-Fayard, B. (2009) Localisation and timing of expression of putative Plasmodium berghei rhoptry proteins in merozoites and sporozoites. Molecular and Biochemical Parasitology, 166(1), pp. 22-31. (doi: 10.1016/j.molbiopara.2009.02.009)

Vega-Rodriguez, J., Franke-Fayard, B., Dinglasan, R.R., Janse, C.J., Pastrana-Mena, R., Rodriguez-Orengo, J.F., Jacobs-Lorena, M., Serrano, A.E., Waters, A. and Srinivasan, P. (2009) The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission. PLoS Pathogens, 5(2), e1000302. (doi: 10.1371/journal.ppat.1000302)

Baum, J., Papenfuss, A.T., Mair, G.R., Janse, C.J., Vlachou, D., Waters, A.P. , Cowman, A.F., Crabb, B.S. and Koning-Ward, T.F. (2009) Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites. Nucleic Acids Research, 37(11), pp. 3788-3798. (doi: 10.1093/nar/gkp239)

Dobson, S. E., Augustijn, K. D., Brannigan, J. A., Schnick, C., Janse, C. J., Dodson, E. J., Waters, A.P. and Wilkinson, A. J. (2009) The crystal structures of macrophage migration inhibitory factor fromPlasmodium falciparumandPlasmodium berghei. Protein Science, 18(12), pp. 2578-2591. (doi: 10.1002/pro.263)

Lavazec, C., Moreira, C.K., Mair, G.R., Waters, A.P. , Janse, C.J. and Templeton, T.J. (2009) Analysis of mutant Plasmodium berghei parasites lacking expression of multiple PbCCp genes. Molecular and Biochemical Parasitology, 163(1), pp. 1-7. (doi: 10.1016/j.molbiopara.2008.09.002)

Moon, R.W., Taylor, C.J., Bex, C., Schepers, R., Goulding, D., Janse, C.J., Waters, A.P., Baker, D.A. and Billker, O. (2009) A cyclic GMP signalling module that regulates gliding motility in a malaria parasite. PLoS Pathogens, 5(9), e1000599. (doi: 10.1371/journal.ppat.1000599)

Yuda, M., Iwanaga, S., Shigenobu, S., Mair, G.R., Janse, C.J., Waters, A.P. , Kato, T. and Kaneko, I. (2009) Identification of a transcription factor in the mosquito-invasive stage of malaria parasites. Molecular Microbiology, 71(6), pp. 1402-1414. (doi: 10.1111/j.1365-2958.2009.06609.x)

Yu, M. et al. (2008) The fatty acid biosynthesis enzyme fabi plays a key role in the development of liver stage malarial parasites. Cell Host and Microbe, 4(6), pp. 567-568. (doi: 10.1016/j.chom.2008.11.001)

van Schaijk, B. C. L. et al. (2008) Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes. PLoS ONE, 3(10), e3549. (doi: 10.1371/journal.pone.0003549)

Braks, J.A.M., Mair, G.R., Franke-Fayard, B., Janse, C.J. and Waters, A.P. (2008) A conserved U-rich RNA region implicated in regulation of translation in Plasmodium female gametocytes. Nucleic Acids Research, 36(4), pp. 1176-1186. (doi: 10.1093/nar/gkm1142)

Di Girolamo, F. et al. (2008) Plasmodium lipid rafts contain proteins implicated in vesicular trafficking and signalling as well as members of the PIR superfamily, potentially implicated in host immune system interactions. Proteomics, 8(12), pp. 2500-2513. (doi: 10.1002/pmic.200700763)

Franke-Fayard, B., Djokovic, D., Dooren, M.W., Ramesar, J., Waters, A.P. , Falade, M.O., Kranendonk, M., Martinelli, A., Cravo, P. and Janse, C.J. (2008) Simple and sensitive antimalarial drug screening in vitro and in vivo using transgenic luciferase expressing Plasmodium berghei parasites. International Journal for Parasitology, 38(14), pp. 1651-1662. (doi: 10.1016/j.ijpara.2008.05.012)

Lasonder, E. et al. (2008) Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity. PLoS Pathogens, 4(10), e1000195. (doi: 10.1371/journal.ppat.1000195)

Moreira, C.K., Templeton, T.J., Lavazec, C., Hayward, R.E., Hobbs, C.V., Kroeze, H., Janse, C.J., Waters, A.P. , Sinnis, P. and Coppi, A. (2008) The Plasmodium TRAPMIC2 family member, TRAP-Like Protein (TLP), is involved in tissue traversal by sporozoites. Cellular Microbiology, 10(7), pp. 1505-1516. (doi: 10.1111/j.1462-5822.2008.01143.x)

van Ooij, C. et al. (2008) The malaria secretome: from algorithms to essential function in blood stage infection. PLoS Pathogens, 4(6), e1000084. (doi: 10.1371/journal.ppat.1000084)

Waters, A.P. (2008) Genome-informed contributions to malaria therapies: feeding somewhere down the (pipe)line. Cell Host and Microbe, 3(5), pp. 280-283. (doi: 10.1016/j.chom.2008.04.005)

This list was generated on Fri Oct 15 16:20:07 2021 BST.