Institute of Infection, Immunity & Inflammation

Dr Ana Da Silva Filipe

NGS Facility Manager (Research Fellow) (Centre for Virus Research)

telephone: 01413306257
email: Ana.daSilvaFilipe@glasgow.ac.uk

Biography

Since joining the University of Glasgow in 2008 as a molecular virologist, I have accumulated extensive experience leading research in viral genomics and transcriptomics. I am passionate about innovation and implementation of sequencing solutions applied to viral systems, while maintaining a focus on quality.

Previously, I worked on gene therapy applied to vascular diseases, where I developed targeted nanovesicles containing viral vectors, for the delivery of therapeutic genes.

Currently lead the CVR Genomics team.

Google scholar: https://scholar.google.co.uk/citations?user=tcZyY6MAAAAJ

Research interests

I lead the CVR Genomics team, which provides the CVR community and collaborators with expertise in high-throughput sequencing, aiming to contribute to the understanding of viruses.

My current research focuses on viral hepatitis and respiratory viruses; I am also driving the development of sequencing solutions for viral emergence and discovery.

Twitter: https://twitter.com/CVR_Genomics

Publications

List by: Type | Date

Jump to: 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2012

Number of items: 22.

2020

Alexander, A. J.T. et al. (2020) Development of a reverse genetics system for Toscana virus (lineage A). Viruses, 12(4), 411. (doi: 10.3390/v12040411)

2019

Childs, K. et al. (2019) Suboptimal SVR rates in African patients with atypical Genotype 1 subtypes: implications for global elimination of Hepatitis C. Journal of Hepatology, 71(6), pp. 1099-1105. (doi: 10.1016/j.jhep.2019.07.025) (PMID:31400349)

Jerome, H. et al. (2019) Metagenomic next-generation sequencing aids the diagnosis of viral infections in febrile returning travellers. Journal of Infection, 79(4), pp. 383-388. (doi: 10.1016/j.jinf.2019.08.003) (PMID:31398374) (PMCID:PMC6859916)

Wing, P. A.C. et al. (2019) Amino acid substitutions in genotype 3a hepatitis C virus polymerase protein affect responses to sofosbuvir. Gastroenterology, 157(3), 692-704.e9. (doi: 10.1053/j.gastro.2019.05.007) (PMID:31078622)

Ankcorn, M. et al. (2019) Convalescent plasma therapy for persistent hepatitis E virus infection. Journal of Hepatology, 71(2), pp. 434-438. (doi: 10.1016/j.jhep.2019.04.008) (PMID:31075322)

Singer, J. B. et al. (2019) Interpreting viral deep sequencing data with GLUE. Viruses, 11(4), 323. (doi: 10.3390/v11040323) (PMID:30987147) (PMCID:PMC6520954)

Davis, C. et al. (2019) New highly diverse hepatitis C strains detected in sub‐Saharan Africa have unknown susceptibility to direct‐acting antiviral treatments. Hepatology, 69(4), pp. 1426-1441. (doi: 10.1002/hep.30342) (PMID:30387174) (PMCID:PMC6492010)

McFarlane, S. et al. (2019) The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection. PLoS Pathogens, 15(3), e1007667. (doi: 10.1371/journal.ppat.1007667) (PMID:30901352) (PMCID:PMC6472835)

Bergner, L. M., Orton, R. J. , da Silva Filipe, A., Shaw, A. E., Becker, D. J., Tello, C., Biek, R. and Streicker, D. G. (2019) Using noninvasive metagenomics to characterize viral communities from wildlife. Molecular Ecology Resources, 19(1), pp. 128-143. (doi: 10.1111/1755-0998.12946) (PMID:30240114)

Ansari, M. A. et al. (2019) Interferon lambda 4 impacts the genetic diversity of hepatitis C virus. eLife, 8, e42463. (doi: 10.7554/eLife.42463.001) (PMID:31478835) (PMCID:PMC6721795)

2018

Dunlop, J. I. et al. (2018) Development of reverse genetics systems and investigation of host response antagonism and reassortment potential for Cache Valley and Kairi viruses, two emerging orthobunyaviruses of the Americas. PLoS Neglected Tropical Diseases, 12(10), e0006884. (doi: 10.1371/journal.pntd.0006884) (PMID:30372452) (PMCID:PMC6245839)

Bamford, C. G.G. et al. (2018) A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages. PLoS Pathogens, 14(10), e1007307. (doi: 10.1371/journal.ppat.1007307) (PMID:30308076) (PMCID:PMC6181419)

Masembe, C. , Sreenu, V. B., Da Silva Filipe, A., Wilkie, G. S., Ogweng, P., Mayega, F. J., Muwanika, V. B., Biek, R. , Palmarini, M. and Davison, A. J. (2018) Genome sequences of five African swine fever virus genotype IX isolates from domestic pigs in Uganda. Microbiology Resource Announcements, 7(13), e01018-18. (doi: 10.1128/mra.01018-18) (PMID:30533685) (PMCID:PMC6256554)

da Silva Filipe, A. et al. (2018) Reply to: "Reply to: 'Response to DAA therapy in the NHS England Early Access Programme for rare HCV subtypes from low and middle income countries'". Journal of Hepatology, 68(4), pp. 864-866. (doi: 10.1016/j.jhep.2017.11.044) (PMID:29339112)

2017

da Silva Filipe, A. et al. (2017) Response to DAA therapy in the NHS England early access programme for rare HCV subtypes from low and middle income countries. Journal of Hepatology, 67(6), pp. 1348-1350. (doi: 10.1016/j.jhep.2017.06.035) (PMID:28789880)

Çevik, R. E., Cesarec, M., Da Silva Filipe, A., Licastro, D., McLauchlan, J. and Marcello, A. (2017) Hepatitis C virus NS5A targets the nucleosome assembly protein NAP1L1 to control the innate cellular response. Journal of Virology, 91(18), e00880-17. (doi: 10.1128/JVI.00880-17) (PMID:28659470)

2016

Donald, C. L. et al. (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Neglected Tropical Diseases, 10(10), e0005048. (doi: 10.1371/journal.pntd.0005048) (PMID:27706161) (PMCID:PMC5051680)

Thomson, E. et al. (2016) Comparison of next generation sequencing technologies for the comprehensive assessment of full-length hepatitis C viral genomes. Journal of Clinical Microbiology, 54(10), pp. 2470-2484. (doi: 10.1128/JCM.00330-16) (PMID:27385709) (PMCID:PMC5035407)

Jacobs, M. et al. (2016) Late Ebola virus relapse causing meningoencephalitis: a case report. Lancet, 388(10043), pp. 498-503. (doi: 10.1016/S0140-6736(16)30386-5) (PMID:27209148) (PMCID:PMC4967715)

2015

Robinson, M. W. et al. (2015) Viral genotype correlates with distinct liver gene transcription signatures in chronic hepatitis C virus infection. Liver International, 35(10), pp. 2256-2264. (doi: 10.1111/liv.12830) (PMID:25800823) (PMCID:PMC4949513)

Filipe, A. and McLauchlan, J. (2015) Hepatitis C virus and lipid droplets: finding a niche. Trends in Molecular Medicine, 21(1), pp. 34-42. (doi: 10.1016/j.molmed.2014.11.003)

2012

Oehler, V., Filipe, A., Montserret, R., da Costa, D., Brown, G., Penin, F. and McLauchlan, J. (2012) Structural analysis of Hepatitis C virus core-E1 signal peptide and requirements for cleavage of the genotype 3a signal sequence by signal peptide peptidase. Journal of Virology, 86(15), pp. 7818-7828. (doi: 10.1128/JVI.00457-12) (PMID:22593157) (PMCID:PMC3421639)

This list was generated on Fri May 29 08:41:12 2020 BST.

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