Dr Ana Da Silva Filipe
- NGS Facility Manager (Research Fellow) (Centre for Virus Research)
telephone: 01413306257
email: Ana.daSilvaFilipe@glasgow.ac.uk
Research interests
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- A pilot study to establish the use of whole genome sequencing in characterising nosocomial influenza cases
Sheffield Teaching Hospitals NHS Foundation Trust
2019 - 2020
- Exploring in-host evolution and viral determinants of enhanced replicative ability of live attenuated influenza vaccine using whole genome sequencing
British Infection Association
2018 - 2020
- Developing innovative and sustainable approaches to prevent the spread fo African swine fever in Africa (ASF-RESIST)
African Union
2018 - 2021
- DENV project
Medical Research Council
2016 - 2019
- Validation of metabolomics as a technique to identify determinants of treatment response in HCV infection (ISSF Catalyst)
Wellcome Trust
2014 - 2015
Publications
2019
Wing, P. A.C. et al. (2019) Amino acid substitutions in genotype 3a hepatitis C virus polymerase protein affect responses to sofosbuvir. Gastroenterology, 157(3), 692-704.e9. (doi:10.1053/j.gastro.2019.05.007) (PMID:31078622)
Childs, K. et al. (2019) Suboptimal SVR rates in African patients with atypical Genotype 1 subtypes: implications for global elimination of Hepatitis C. Journal of Hepatology, (doi:10.1016/j.jhep.2019.07.025) (PMID:31400349) (In Press)
Jerome, H. et al. (2019) Metagenomic next-generation sequencing aids the diagnosis of viral infections in febrile returning travellers. Journal of Infection, (doi:10.1016/j.jinf.2019.08.003) (PMID:31398374) (In Press)
Ankcorn, M. et al. (2019) Convalescent plasma therapy for persistent hepatitis E virus infection. Journal of Hepatology, 71(2), pp. 434-438. (doi:10.1016/j.jhep.2019.04.008) (PMID:31075322)
Singer, J. B. et al. (2019) Interpreting viral deep sequencing data with GLUE. Viruses, 11(4), 323. (doi:10.3390/v11040323) (PMID:30987147) (PMCID:PMC6520954)
Davis, C. et al. (2019) New highly diverse hepatitis C strains detected in sub‐Saharan Africa have unknown susceptibility to direct‐acting antiviral treatments. Hepatology, 69(4), pp. 1426-1441. (doi:10.1002/hep.30342) (PMID:30387174) (PMCID:PMC6492010)
McFarlane, S. et al. (2019) The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection. PLoS Pathogens, 15(3), e1007667. (doi:10.1371/journal.ppat.1007667) (PMID:30901352) (PMCID:PMC6472835)
Bergner, L. M., Orton, R. J. , da Silva Filipe, A., Shaw, A. E., Becker, D. J., Tello, C., Biek, R. and Streicker, D. G. (2019) Using noninvasive metagenomics to characterize viral communities from wildlife. Molecular Ecology Resources, 19(1), pp. 128-143. (doi:10.1111/1755-0998.12946) (PMID:30240114)
Ansari, M. A. et al. (2019) Interferon lambda 4 impacts the genetic diversity of hepatitis C virus. eLife, 8, e42463. (doi:10.7554/eLife.42463.001) (PMID:31478835) (PMCID:PMC6721795)
2018
Dunlop, J. I. et al. (2018) Development of reverse genetics systems and investigation of host response antagonism and reassortment potential for Cache Valley and Kairi viruses, two emerging orthobunyaviruses of the Americas. PLoS Neglected Tropical Diseases, 12(10), e0006884. (doi:10.1371/journal.pntd.0006884) (PMID:30372452) (PMCID:PMC6245839)
Bamford, C. G.G. et al. (2018) A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages. PLoS Pathogens, 14(10), e1007307. (doi:10.1371/journal.ppat.1007307) (PMID:30308076) (PMCID:PMC6181419)
Masembe, C. , Sreenu, V. B., Da Silva Filipe, A., Wilkie, G. S., Ogweng, P., Mayega, F. J., Muwanika, V. B., Biek, R. , Palmarini, M. and Davison, A. J. (2018) Genome sequences of five African swine fever virus genotype IX isolates from domestic pigs in Uganda. Microbiology Resource Announcements, 7(13), e01018-18. (doi:10.1128/mra.01018-18) (PMID:30533685) (PMCID:PMC6256554)
da Silva Filipe, A. et al. (2018) Reply to: "Reply to: 'Response to DAA therapy in the NHS England Early Access Programme for rare HCV subtypes from low and middle income countries'". Journal of Hepatology, 68(4), pp. 864-866. (doi:10.1016/j.jhep.2017.11.044) (PMID:29339112)
2017
da Silva Filipe, A. et al. (2017) Response to DAA therapy in the NHS England early access programme for rare HCV subtypes from low and middle income countries. Journal of Hepatology, 67(6), pp. 1348-1350. (doi:10.1016/j.jhep.2017.06.035) (PMID:28789880)
Çevik, R. E., Cesarec, M., Da Silva Filipe, A., Licastro, D., McLauchlan, J. and Marcello, A. (2017) Hepatitis C virus NS5A targets the nucleosome assembly protein NAP1L1 to control the innate cellular response. Journal of Virology, 91(18), e00880-17. (doi:10.1128/JVI.00880-17) (PMID:28659470)
2016
Donald, C. L. et al. (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Neglected Tropical Diseases, 10(10), e0005048. (doi:10.1371/journal.pntd.0005048) (PMID:27706161) (PMCID:PMC5051680)
Thomson, E. et al. (2016) Comparison of next generation sequencing technologies for the comprehensive assessment of full-length hepatitis C viral genomes. Journal of Clinical Microbiology, 54(10), pp. 2470-2484. (doi:10.1128/JCM.00330-16) (PMID:27385709) (PMCID:PMC5035407)
Jacobs, M. et al. (2016) Late Ebola virus relapse causing meningoencephalitis: a case report. Lancet, 388(10043), pp. 498-503. (doi:10.1016/S0140-6736(16)30386-5) (PMID:27209148) (PMCID:PMC4967715)
2015
Robinson, M. W. et al. (2015) Viral genotype correlates with distinct liver gene transcription signatures in chronic hepatitis C virus infection. Liver International, 35(10), pp. 2256-2264. (doi:10.1111/liv.12830) (PMID:25800823) (PMCID:PMC4949513)
Filipe, A. and McLauchlan, J. (2015) Hepatitis C virus and lipid droplets: finding a niche. Trends in Molecular Medicine, 21(1), pp. 34-42. (doi:10.1016/j.molmed.2014.11.003)
2012
Oehler, V., Filipe, A., Montserret, R., da Costa, D., Brown, G., Penin, F. and McLauchlan, J. (2012) Structural analysis of Hepatitis C virus core-E1 signal peptide and requirements for cleavage of the genotype 3a signal sequence by signal peptide peptidase. Journal of Virology, 86(15), pp. 7818-7828. (doi:10.1128/JVI.00457-12) (PMID:22593157) (PMCID:PMC3421639)
Articles
Wing, P. A.C. et al. (2019) Amino acid substitutions in genotype 3a hepatitis C virus polymerase protein affect responses to sofosbuvir. Gastroenterology, 157(3), 692-704.e9. (doi:10.1053/j.gastro.2019.05.007) (PMID:31078622)
Childs, K. et al. (2019) Suboptimal SVR rates in African patients with atypical Genotype 1 subtypes: implications for global elimination of Hepatitis C. Journal of Hepatology, (doi:10.1016/j.jhep.2019.07.025) (PMID:31400349) (In Press)
Jerome, H. et al. (2019) Metagenomic next-generation sequencing aids the diagnosis of viral infections in febrile returning travellers. Journal of Infection, (doi:10.1016/j.jinf.2019.08.003) (PMID:31398374) (In Press)
Ankcorn, M. et al. (2019) Convalescent plasma therapy for persistent hepatitis E virus infection. Journal of Hepatology, 71(2), pp. 434-438. (doi:10.1016/j.jhep.2019.04.008) (PMID:31075322)
Singer, J. B. et al. (2019) Interpreting viral deep sequencing data with GLUE. Viruses, 11(4), 323. (doi:10.3390/v11040323) (PMID:30987147) (PMCID:PMC6520954)
Davis, C. et al. (2019) New highly diverse hepatitis C strains detected in sub‐Saharan Africa have unknown susceptibility to direct‐acting antiviral treatments. Hepatology, 69(4), pp. 1426-1441. (doi:10.1002/hep.30342) (PMID:30387174) (PMCID:PMC6492010)
McFarlane, S. et al. (2019) The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection. PLoS Pathogens, 15(3), e1007667. (doi:10.1371/journal.ppat.1007667) (PMID:30901352) (PMCID:PMC6472835)
Bergner, L. M., Orton, R. J. , da Silva Filipe, A., Shaw, A. E., Becker, D. J., Tello, C., Biek, R. and Streicker, D. G. (2019) Using noninvasive metagenomics to characterize viral communities from wildlife. Molecular Ecology Resources, 19(1), pp. 128-143. (doi:10.1111/1755-0998.12946) (PMID:30240114)
Ansari, M. A. et al. (2019) Interferon lambda 4 impacts the genetic diversity of hepatitis C virus. eLife, 8, e42463. (doi:10.7554/eLife.42463.001) (PMID:31478835) (PMCID:PMC6721795)
Dunlop, J. I. et al. (2018) Development of reverse genetics systems and investigation of host response antagonism and reassortment potential for Cache Valley and Kairi viruses, two emerging orthobunyaviruses of the Americas. PLoS Neglected Tropical Diseases, 12(10), e0006884. (doi:10.1371/journal.pntd.0006884) (PMID:30372452) (PMCID:PMC6245839)
Bamford, C. G.G. et al. (2018) A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages. PLoS Pathogens, 14(10), e1007307. (doi:10.1371/journal.ppat.1007307) (PMID:30308076) (PMCID:PMC6181419)
Masembe, C. , Sreenu, V. B., Da Silva Filipe, A., Wilkie, G. S., Ogweng, P., Mayega, F. J., Muwanika, V. B., Biek, R. , Palmarini, M. and Davison, A. J. (2018) Genome sequences of five African swine fever virus genotype IX isolates from domestic pigs in Uganda. Microbiology Resource Announcements, 7(13), e01018-18. (doi:10.1128/mra.01018-18) (PMID:30533685) (PMCID:PMC6256554)
da Silva Filipe, A. et al. (2018) Reply to: "Reply to: 'Response to DAA therapy in the NHS England Early Access Programme for rare HCV subtypes from low and middle income countries'". Journal of Hepatology, 68(4), pp. 864-866. (doi:10.1016/j.jhep.2017.11.044) (PMID:29339112)
da Silva Filipe, A. et al. (2017) Response to DAA therapy in the NHS England early access programme for rare HCV subtypes from low and middle income countries. Journal of Hepatology, 67(6), pp. 1348-1350. (doi:10.1016/j.jhep.2017.06.035) (PMID:28789880)
Çevik, R. E., Cesarec, M., Da Silva Filipe, A., Licastro, D., McLauchlan, J. and Marcello, A. (2017) Hepatitis C virus NS5A targets the nucleosome assembly protein NAP1L1 to control the innate cellular response. Journal of Virology, 91(18), e00880-17. (doi:10.1128/JVI.00880-17) (PMID:28659470)
Donald, C. L. et al. (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Neglected Tropical Diseases, 10(10), e0005048. (doi:10.1371/journal.pntd.0005048) (PMID:27706161) (PMCID:PMC5051680)
Thomson, E. et al. (2016) Comparison of next generation sequencing technologies for the comprehensive assessment of full-length hepatitis C viral genomes. Journal of Clinical Microbiology, 54(10), pp. 2470-2484. (doi:10.1128/JCM.00330-16) (PMID:27385709) (PMCID:PMC5035407)
Jacobs, M. et al. (2016) Late Ebola virus relapse causing meningoencephalitis: a case report. Lancet, 388(10043), pp. 498-503. (doi:10.1016/S0140-6736(16)30386-5) (PMID:27209148) (PMCID:PMC4967715)
Robinson, M. W. et al. (2015) Viral genotype correlates with distinct liver gene transcription signatures in chronic hepatitis C virus infection. Liver International, 35(10), pp. 2256-2264. (doi:10.1111/liv.12830) (PMID:25800823) (PMCID:PMC4949513)
Filipe, A. and McLauchlan, J. (2015) Hepatitis C virus and lipid droplets: finding a niche. Trends in Molecular Medicine, 21(1), pp. 34-42. (doi:10.1016/j.molmed.2014.11.003)
Oehler, V., Filipe, A., Montserret, R., da Costa, D., Brown, G., Penin, F. and McLauchlan, J. (2012) Structural analysis of Hepatitis C virus core-E1 signal peptide and requirements for cleavage of the genotype 3a signal sequence by signal peptide peptidase. Journal of Virology, 86(15), pp. 7818-7828. (doi:10.1128/JVI.00457-12) (PMID:22593157) (PMCID:PMC3421639)
Centre for Virus Research, Sir Michael Stoker Building, 464 Bearsden Road, Glasgow, G61 1qh,