Dr Adam Fletcher

  • Research Fellow: UKRI Future Leadership Fellow (Centre for Virus Research)

Publications

List by: Type | Date

Jump to: 2021 | 2020 | 2019 | 2018 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2008
Number of items: 18.

2021

De Cesare, V., Carbajo Lopez, D., Mabbitt, P. D., Fletcher, A. J., Soetens, M., Antico, O., Wood, N. T. and Virdee, S. (2021) Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases. Proceedings of the National Academy of Sciences, 118(4), e200694711. (doi: 10.1073/pnas.2006947118) (PMID:33479176) (PMCID:PMC7848729)

2020

Mabbitt, P. D., Loreto, A., Déry, M.-A., Fletcher, A. J., Stanley, M., Pao, K.-C., Wood, N. T., Coleman, M. P. and Virdee, S. (2020) Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity. Nature Chemical Biology, 16(11), pp. 1227-1236. (doi: 10.1038/s41589-020-0598-6) (PMID:32747811) (PMCID:PMC7610530)

2019

Mallery, D. L. et al. (2019) Cellular IP6 levels limit HIV production while viruses that cannot efficiently package IP6 are attenuated for infection and replication. Cell Reports, 29(12), 3983-3996.e4. (doi: 10.1016/j.celrep.2019.11.050) (PMID:31851928) (PMCID:PMC6931105)

Mathur, S., Fletcher, A. J., Branigan, E., Hay, R. T. and Virdee, S. (2019) Photocrosslinking activity-based probes for ubiquitin RING E3 ligases. Cell Chemical Biology, 27(1), 74-82.e6. (doi: 10.1016/j.chembiol.2019.11.013) (PMID:31859248) (PMCID:PMC6963778)

2018

Fletcher, A. J., Vaysburd, M., Maslen, S., Zeng, J., Skehel, J. M., Towers, G. J. and James, L. C. (2018) Trivalent RING assembly on retroviral capsids activates TRIM5 ubiquitination and innate immune signaling. Cell Host and Microbe, 24(6), 761-775.e6. (doi: 10.1016/j.chom.2018.10.007) (PMID:30503508) (PMCID:PMC6299210)

Dickson, C. et al. (2018) Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21. eLife, 7, e32660. (doi: 10.7554/eLife.32660)

2016

Fletcher, A. J., James, L. C. and Tsai, B. (2016) Coordinated neutralization and immune activation by the cytosolic antibody receptor TRIM21. Journal of Virology, 90(10), pp. 4856-4859. (doi: 10.1128/JVI.00050-16) (PMID:26937031) (PMCID:PMC4859718)

2015

Fletcher, A. J., Mallery, D. L., Watkinson, R. E., Dickson, C. F. and James, L. C. (2015) Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21. Proceedings of the National Academy of Sciences, 112(32), pp. 10014-10019. (doi: 10.1073/pnas.1507534112) (PMID:26150489) (PMCID:PMC4538650)

Fletcher, A. J., Christensen, D. E., Nelson, C., Tan, C. P., Schaller, T., Lehner, P. J., Sundquist, W. I. and Towers, G. J. (2015) TRIM 5α requires Ube2W to anchor Lys63‐linked ubiquitin chains and restrict reverse transcription. EMBO Journal, 34(15), pp. 2078-2095. (doi: 10.15252/embj.201490361) (PMID:26101372) (PMCID:PMC4551353)

2014

Guiliano, D. B. et al. (2014) Endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation. Arthritis and Rheumatology, 66(11), pp. 2976-2988. (doi: 10.1002/art.38809) (PMID:25132672) (PMCID:PMC4399817)

Cullen, B. R., Price, A. J., Jacques, D. A., McEwan, W. A., Fletcher, A. J., Essig, S., Chin, J. W., Halambage, U. D., Aiken, C. and James, L. C. (2014) Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly. PLoS Pathogens, 10(10), e1004459. (doi: 10.1371/journal.ppat.1004459) (PMID:25356722) (PMCID:PMC4214760)

2013

Rasaiyaah, J. et al. (2013) HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature, 503(7476), pp. 402-405. (doi: 10.1038/nature12769) (PMID:24196705) (PMCID:PMC3928559)

Fletcher, A. J. and Towers, G. J. (2013) Inhibition of retroviral replication by members of the TRIM protein family. In: Cullen, B. (ed.) Intrinsic Immunity. Series: Current topics in microbiology and immunology (371). Springer, pp. 29-66. ISBN 9783642377655 (doi:10.1007/978-3-642-37765-5_2)

2012

Krausslich, H.-G., Price, A. J., Fletcher, A. J., Schaller, T., Elliott, T., Lee, K., KewalRamani, V. N., Chin, J. W., Towers, G. J. and James, L. C. (2012) CPSF6 defines a conserved capsid interface that modulates HIV-1 replication. PLoS Pathogens, 8(8), e1002896. (doi: 10.1371/journal.ppat.1002896) (PMID:22956906) (PMCID:PMC3431306)

2011

Aiken, C. et al. (2011) HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency. PLoS Pathogens, 7(12), e1002439. (doi: 10.1371/journal.ppat.1002439) (PMID:22174692) (PMCID:PMC3234246)

2010

Fletcher, A. J., Hué, S., Schaller, T., Pillay, D. and Towers, G. J. (2010) Hare TRIM5α restricts divergent retroviruses and exhibits significant sequence variation from closely related Lagomorpha TRIM5 genes. Journal of Virology, 84(23), pp. 12463-12468. (doi: 10.1128/jvi.01514-10) (PMID:20861252) (PMCID:PMC2976397)

Ylinen, L. M. J., Schaller, T., Price, A., Fletcher, A. J., Noursadeghi, M., James, L. C. and Towers, G. J. (2010) Cyclophilin A levels dictate infection efficiency of human immunodeficiency virus type 1 capsid escape mutants A92E and G94D. Journal of Virology, 83(4), pp. 2044-2047. (doi: 10.1128/jvi.01876-08) (PMID:19073742) (PMCID:PMC2643744)

2008

Lyulcheva, E., Taylor, E., Michael, M., Vehlow, A., Tan, S., Fletcher, A., Krause, M. and Bennett, D. (2008) Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation. Developmental Cell, 15(5), pp. 680-690. (doi: 10.1016/j.devcel.2008.09.020) (PMID:19000833) (PMCID:PMC2691947)

This list was generated on Sat Oct 16 13:31:29 2021 BST.
Number of items: 18.

Articles

De Cesare, V., Carbajo Lopez, D., Mabbitt, P. D., Fletcher, A. J., Soetens, M., Antico, O., Wood, N. T. and Virdee, S. (2021) Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases. Proceedings of the National Academy of Sciences, 118(4), e200694711. (doi: 10.1073/pnas.2006947118) (PMID:33479176) (PMCID:PMC7848729)

Mabbitt, P. D., Loreto, A., Déry, M.-A., Fletcher, A. J., Stanley, M., Pao, K.-C., Wood, N. T., Coleman, M. P. and Virdee, S. (2020) Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity. Nature Chemical Biology, 16(11), pp. 1227-1236. (doi: 10.1038/s41589-020-0598-6) (PMID:32747811) (PMCID:PMC7610530)

Mallery, D. L. et al. (2019) Cellular IP6 levels limit HIV production while viruses that cannot efficiently package IP6 are attenuated for infection and replication. Cell Reports, 29(12), 3983-3996.e4. (doi: 10.1016/j.celrep.2019.11.050) (PMID:31851928) (PMCID:PMC6931105)

Mathur, S., Fletcher, A. J., Branigan, E., Hay, R. T. and Virdee, S. (2019) Photocrosslinking activity-based probes for ubiquitin RING E3 ligases. Cell Chemical Biology, 27(1), 74-82.e6. (doi: 10.1016/j.chembiol.2019.11.013) (PMID:31859248) (PMCID:PMC6963778)

Fletcher, A. J., Vaysburd, M., Maslen, S., Zeng, J., Skehel, J. M., Towers, G. J. and James, L. C. (2018) Trivalent RING assembly on retroviral capsids activates TRIM5 ubiquitination and innate immune signaling. Cell Host and Microbe, 24(6), 761-775.e6. (doi: 10.1016/j.chom.2018.10.007) (PMID:30503508) (PMCID:PMC6299210)

Dickson, C. et al. (2018) Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21. eLife, 7, e32660. (doi: 10.7554/eLife.32660)

Fletcher, A. J., James, L. C. and Tsai, B. (2016) Coordinated neutralization and immune activation by the cytosolic antibody receptor TRIM21. Journal of Virology, 90(10), pp. 4856-4859. (doi: 10.1128/JVI.00050-16) (PMID:26937031) (PMCID:PMC4859718)

Fletcher, A. J., Mallery, D. L., Watkinson, R. E., Dickson, C. F. and James, L. C. (2015) Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21. Proceedings of the National Academy of Sciences, 112(32), pp. 10014-10019. (doi: 10.1073/pnas.1507534112) (PMID:26150489) (PMCID:PMC4538650)

Fletcher, A. J., Christensen, D. E., Nelson, C., Tan, C. P., Schaller, T., Lehner, P. J., Sundquist, W. I. and Towers, G. J. (2015) TRIM 5α requires Ube2W to anchor Lys63‐linked ubiquitin chains and restrict reverse transcription. EMBO Journal, 34(15), pp. 2078-2095. (doi: 10.15252/embj.201490361) (PMID:26101372) (PMCID:PMC4551353)

Guiliano, D. B. et al. (2014) Endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation. Arthritis and Rheumatology, 66(11), pp. 2976-2988. (doi: 10.1002/art.38809) (PMID:25132672) (PMCID:PMC4399817)

Cullen, B. R., Price, A. J., Jacques, D. A., McEwan, W. A., Fletcher, A. J., Essig, S., Chin, J. W., Halambage, U. D., Aiken, C. and James, L. C. (2014) Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly. PLoS Pathogens, 10(10), e1004459. (doi: 10.1371/journal.ppat.1004459) (PMID:25356722) (PMCID:PMC4214760)

Rasaiyaah, J. et al. (2013) HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature, 503(7476), pp. 402-405. (doi: 10.1038/nature12769) (PMID:24196705) (PMCID:PMC3928559)

Krausslich, H.-G., Price, A. J., Fletcher, A. J., Schaller, T., Elliott, T., Lee, K., KewalRamani, V. N., Chin, J. W., Towers, G. J. and James, L. C. (2012) CPSF6 defines a conserved capsid interface that modulates HIV-1 replication. PLoS Pathogens, 8(8), e1002896. (doi: 10.1371/journal.ppat.1002896) (PMID:22956906) (PMCID:PMC3431306)

Aiken, C. et al. (2011) HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency. PLoS Pathogens, 7(12), e1002439. (doi: 10.1371/journal.ppat.1002439) (PMID:22174692) (PMCID:PMC3234246)

Fletcher, A. J., Hué, S., Schaller, T., Pillay, D. and Towers, G. J. (2010) Hare TRIM5α restricts divergent retroviruses and exhibits significant sequence variation from closely related Lagomorpha TRIM5 genes. Journal of Virology, 84(23), pp. 12463-12468. (doi: 10.1128/jvi.01514-10) (PMID:20861252) (PMCID:PMC2976397)

Ylinen, L. M. J., Schaller, T., Price, A., Fletcher, A. J., Noursadeghi, M., James, L. C. and Towers, G. J. (2010) Cyclophilin A levels dictate infection efficiency of human immunodeficiency virus type 1 capsid escape mutants A92E and G94D. Journal of Virology, 83(4), pp. 2044-2047. (doi: 10.1128/jvi.01876-08) (PMID:19073742) (PMCID:PMC2643744)

Lyulcheva, E., Taylor, E., Michael, M., Vehlow, A., Tan, S., Fletcher, A., Krause, M. and Bennett, D. (2008) Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation. Developmental Cell, 15(5), pp. 680-690. (doi: 10.1016/j.devcel.2008.09.020) (PMID:19000833) (PMCID:PMC2691947)

Book Sections

Fletcher, A. J. and Towers, G. J. (2013) Inhibition of retroviral replication by members of the TRIM protein family. In: Cullen, B. (ed.) Intrinsic Immunity. Series: Current topics in microbiology and immunology (371). Springer, pp. 29-66. ISBN 9783642377655 (doi:10.1007/978-3-642-37765-5_2)

This list was generated on Sat Oct 16 13:31:29 2021 BST.

Visit the Fletcher Group webpage