Dr Karla Neves
- Honorary Research Fellow (School of Cardiovascular & Metabolic Health)
email:
Karla.Neves@glasgow.ac.uk
126 UNIVERSITY PLACE, Room 340, G12 8TA
https://orcid.org/0000-0001-5158-9263Biography
Bachelor’s degree in nursing from the Federal University of Mato Grosso, Brazil (2009). Master's Degree in Sciences from the FCFRP-USP Pharmaceutical Sciences program at the University of São Paulo-USP, Ribeirao Preto, Brazil (2012). Doctorate Degree in Sciences in the same University program. During PhD, I developed one-year training at the British Heart Foundation (BHF) at the University of Glasgow in Prof. Rhian Touyz`s lab and I am currently a Research Associate at the Institute of Cardiovascular and Medical Sciences - University of Glasgow.
Research interests
Currently working on the vascular and molecular mechanisms by which VEGF inhibitors cause cardiovascular toxicities, focusing mainly on the role of microparticles, NAD(P)H oxidases and the antioxidant system. We are also interested in elucidating how a Notch3 mutation in CADASIL affects peripheral small vessels causing vascular dysfunction.
Publications
2023
Montezano, A. C. et al. (2023) SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication. Scientific Reports, 13, 14086. (doi: 10.1038/s41598-023-41115-3) (PMID:37640791) (PMCID:PMC10462711)
Morris, H. E., Neves, K. B. , Nilsen, M., Montezano, A. C., MacLean, M. R. and Touyz, R. M. (2023) Notch3/Hes5 induces vascular dysfunction in hypoxia-induced pulmonary hypertension through ER stress and redox-sensitive pathways. Hypertension, 80(8), pp. 1683-1696. (doi: 10.1161/hypertensionaha.122.20449) (PMID:37254738)
Sykes, R. A. et al. (2023) Vascular mechanisms of post-COVID-19 conditions: rho-kinase is a novel target for therapy. European Heart Journal: Cardiovascular Pharmacotherapy, 9(4), pp. 371-386. (doi: 10.1093/ehjcvp/pvad025) (PMID:37019821) (PMCID:PMC10236521)
Neves, K. B. , Alves‐Lopes, R. , Montezano, A. C. and Touyz, R. M. (2023) Role of PARP and TRPM2 in VEGF inhibitor‐induced vascular dysfunction. Journal of the American Heart Association, 12(4), e027769. (doi: 10.1161/JAHA.122.027769) (PMID:36802924) (PMCID:PMC10111475)
2022
Rios, F. J. et al. (2022) TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt. Communications Biology, 5, 746. (doi: 10.1038/s42003-022-03715-z) (PMID:35882956) (PMCID:PMC9325869)
Mirabito Colafella, K. M. et al. (2022) Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage. Clinical Science, 136(9), pp. 675-694. (doi: 10.1042/CS20220182) (PMID:35441670) (PMCID:PMC9093150)
Camargo, L. L. et al. (2022) Central role of c-Src in NOX5- mediated redox signaling in vascular smooth muscle cells in human hypertension. Cardiovascular Research, 118(5), pp. 1359-1373. (doi: 10.1093/cvr/cvab171) (PMID:34320175) (PMCID:PMC8953456)
Neves, K. B. , Rios, F. J. , Sevilla-Montero, J., Montezano, A. C. and Touyz, R. M. (2022) Exosomes and the cardiovascular system: role in cardiovascular health and disease. Journal of Physiology, (doi: 10.1113/JP282054) (PMID:35306667) (Early Online Publication)
2021
Alves-Lopes, R. et al. (2021) Selective inhibition of the C-domain of ACE (angiotensin-converting enzyme) combined with inhibition of NEP (neprilysin): a potential new therapy for hypertension. Hypertension, 78(3), pp. 604-616. (doi: 10.1161/HYPERTENSIONAHA.121.17041) (PMID:34304582) (PMCID:PMC8357049)
Da Silva, J. F. et al. (2021) Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation - implications in atherosclerosis. Clinical Science, 135(15), pp. 1845-1858. (doi: 10.1042/CS20210468) (PMID:34269800)
van Dorst, D. C.H., Dobbin, S. J.H. , Neves, K. B. , Herrmann, J., Herrmann, S. M., Versmissen, J., Mathijssen, R. H.J., Danser, A.H. J. and Lang, N. N. (2021) Hypertension and prohypertensive antineoplastic therapies in cancer patients. Circulation Research, 128(7), pp. 1040-1061. (doi: 10.1161/CIRCRESAHA.121.318051) (PMID:33793337) (PMCID:PMC8011349)
Cameron, A. C., Neves, K. B. , White, J., Touyz, R. M. and Lang, N. N. (2021) Reply: Cisplatin-associated aortic thrombosis: a review of cases reported to the FDA adverse event reporting system. JACC: CardioOncology, 3(1), p. 166. (doi: 10.1016/j.jaccao.2021.01.005)
Neves, K. B. , Morris, H., Alves-Lopes, R., Muir, K. W. , Moreton, F., Delles, C. , Montezano, A. C. and Touyz, R. M. (2021) Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO∕sGC∕cGMP pathway. Clinical Science, 135(6), pp. 753-773. (doi: 10.1042/CS20201412) (PMID:33681964)
2020
Rossitto, G. et al. (2020) Reduced lymphatic reserve in heart failure with preserved ejection fraction. Journal of the American College of Cardiology, 76(24), pp. 2817-2829. (doi: 10.1016/j.jacc.2020.10.022) (PMID:33303070) (PMCID:PMC7724570)
Cameron, A. C. et al. (2020) Comprehensive characterisation of the vascular effects of cisplatin-based chemotherapy in patients with testicular cancer. JACC: CardioOncology, 2(3), pp. 443-455. (doi: 10.1016/j.jaccao.2020.06.004) (PMID:33043304) (PMCID:PMC7539369)
Rossitto, G. et al. (2020) Tissue sodium excess is not hypertonic and reflects extracellular volume expansion. Nature Communications, 11, 4222. (doi: 10.1038/s41467-020-17820-2) (PMID:32839436) (PMCID:PMC7445299)
Zou, Z.-G. et al. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. Clinical Science, 134(15), pp. 2019-2035. (doi: 10.1042/CS20200827) (PMID:32706027) (PMCID:PMC8299307)
Touyz, R. , Rios, F. , Alves-Lopes, R., Neves, K. B. , De Lucca Camargo, L. and Montezano, A. C. (2020) Oxidative stress: a unifying paradigm in hypertension. Canadian Journal of Cardiology, 36, pp. 659-670. (doi: 10.1016/j.cjca.2020.02.081) (PMID:32389339) (PMCID:PMC7225748)
Cameron, A. C., Welsh, P. , Neves, K. B. , Newby, D., Touyz, R. M. and Lang, N. (2020) Acute vascular effects of vascular endothelial growth factor inhibition in the forearm arterial circulation. Journal of Hypertension, 38(2), pp. 257-265. (doi: 10.1097/HJH.0000000000002230) (PMID:31449168) (PMCID:PMC7197298)
Alves-Lopes, R., Neves, K. B. , Anagnostopoulou, A., Rios, F. J. , Lacchini, S., Montezano, A. C. and Touyz, R. M. (2020) Crosstalk between vascular redox and calcium signaling in hypertension involves TRPM2 (Transient Receptor Potential Melastatin 2) cation channel. Hypertension, 75(1), pp. 139-149. (doi: 10.1161/hypertensionaha.119.13861) (PMID:31735084)
2019
Morris, H., Neves, K. B. , Montezano, A. C., Maclean, M. R. and Touyz, R. (2019) Notch3 signaling and vascular remodeling in pulmonary arterial hypertension. Clinical Science, 133(24), pp. 2481-2498. (doi: 10.1042/CS20190835) (PMID:31868216) (PMCID:PMC6928565)
Neves, K. B. et al. (2019) ER stress and Rho kinase activation underlie the vasculopathy of CADASIL. JCI Insight, 4(23), e131344. (doi: 10.1172/jci.insight.131344) (PMID:31647781) (PMCID:PMC6962020)
Neves, K. B. and Touyz, R. M. (2019) Extracellular vesicles as biomarkers and biovectors in primary aldosteronism. Hypertension, 74(2), pp. 250-252. (doi: 10.1161/hypertensionaha.119.13088) (PMID:31230536)
Alves-Lopes, R., Neves, K. B. and Touyz, R. M. (2019) Muscarinic receptor type-3 (MR3) in hypertension and cholinergic-adrenergic crosstalk: genetic insights and potential for new antihypertensive targets. Canadian Journal of Cardiology, 35(5), pp. 555-557. (doi: 10.1016/j.cjca.2019.02.003) (PMID:30954389) (PMCID:PMC6499128)
Neves, K. B. , Rios, F. J. , Jones, R. , Evans, T. R. J. , Montezano, A. C. and Touyz, R. M. (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115(5), pp. 978-988. (doi: 10.1093/cvr/cvz021) (PMID:30753341) (PMCID:PMC6452312)
Neves, K. B. and Touyz, R. M. (2019) Vascular signaling. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 83-91. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_8)
2018
Neves, K. B. , Nguyen Dinh Cat, A., Alves-Lopes, R. , Harvey, K. Y., da Costa, R. M., Lobato, N. S., Montezano, A. C., Oliveira, A. M., Touyz, R. M. and Tostes, R. C. (2018) Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways. American Journal of Physiology: Heart and Circulatory Physiology, 315(6), H1851-H1860. (doi: 10.1152/ajpheart.00285.2018) (PMID:30216119) (PMCID:PMC6336978)
Neves, K. B. , Montezano, A. C., Alves-Lopes, R. , Bruder-Nascimento, T., Costa, R. M., Costa, R. S., Touyz, R. M. and Tostes, R. C. (2018) Upregulation of Nrf2 and decreased redox signaling contribute to renoprotective effects of chemerin receptor blockade in diabetic mice. International Journal of Molecular Sciences, 19(8), 2454. (doi: 10.3390/ijms19082454) (PMID:30126255) (PMCID:PMC6121242)
Montezano, A. C. et al. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), e009388. (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)
Montezano, A. C. et al. (2018) NADPH Oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)
Neves, K. B. , Rios, F. J. , Van Der Mey, L., Alves-Lopes, R. , Cameron, A. C., Volpe, M., Montezano, A. C., Savoia, C. and Touyz, R. M. (2018) VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71(4), pp. 638-647. (doi: 10.1161/HYPERTENSIONAHA.117.10490) (PMID:29483228)
Costa, R. M., Neves, K. B. , Tostes, R. C. and Lobato, N. S. (2018) Perivascular adipose tissue as a relevant fat depot for cardiovascular risk in obesity. Frontiers in Physiology, 9, 253. (doi: 10.3389/fphys.2018.00253)
Souza-Silva, L., Alves-Lopes, R. , Silva Miguez, J., Dela Justina, V., Neves, K. B. , Mestriner, F. L., Tostes, R. C., Giachini, F. R. and Lima, V. V. (2018) Glycosylation with O-linked β-N-acetylglucosamine (O-GlcNAc) induces vascular dysfunction via production of superoxide anion/reactive oxygen species. Canadian Journal of Physiology and Pharmacology, 96(3), pp. 232-240. (doi: 10.1139/cjpp-2017-0225) (PMID:28793197)
2017
Carneiro, F. S., Alves-Lopes, R. , Neves, K. B. , Silva, M. A.B., Olivon, V. C., Ruginsk, S. G., Antunes-Rodrigues, J., Ramalho, L. N.Z. and Tostes, R. C. (2017) Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation. Asian Journal of Andrology, 19(5), pp. 526-532. (doi: 10.4103/1008-682X.173935) (PMID:27391248) (PMCID:PMC5566844)
Montezano, A. C., Lopes, R. A.M. , Neves, K. B. , Rios, F. and Touyz, R. M. (2017) Isolation and culture of vascular smooth muscle cells from small and large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 349-354. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_27)
Montezano, A. C., Neves, K. B. , Lopes, R. A.M. and Rios, F. (2017) Isolation and culture of endothelial cells from large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 345-348. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_26)
2016
Alves-Lopes, R. , Neves, K. B. , Montezano, A., Harvey, A., Carneiro, F. S., Touyz, R. and Tostes, R. C. (2016) Internal pudendal artery dysfunction in diabetes is mediated by Nox1-derived Ros, NRF2- and RHO kinase-depedent mechanisms. Hypertension, 68(4), pp. 1056-1064. (doi: 10.1161/HYPERTENSIONAHA.116.07518) (PMID:27528061)
2015
Lopes, R. , Neves, K. , Tostes, R., Montezano, A. and Touyz, R. (2015) Downregulation of nuclear factor erythroid 2–related factor and associated antioxidant genes contributes to redox-sensitive vascular dysfunction in hypertension. Hypertension, 2015(66), pp. 1240-1250. (doi: 10.1161/hypertensionaha.115.06163) (PMID:26503970)
Silva, M. A. B. et al. (2015) Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus. Clinical Science, 129(7), pp. 533-545. (doi: 10.1042/cs20140758) (PMID:25967696)
2014
Lopes, R. A. M. , Neves, K. B. , Pestana, C. R., Queiroz, A. L., Zanotto, C. Z., Chignalia, A. Z., Valim, Y. M., Silveira, L. R., Curti, C. and Tostes, R. C. (2014) Testosterone induces apoptosis in vascular smooth muscle cells via extrinsic apoptotic pathway with mitochondria-generated reactive oxygen species involvement. American Journal of Physiology: Heart and Circulatory Physiology, 306(11), H1485-H1494. (doi: 10.1152/ajpheart.00809.2013) (PMID:24658017)
2012
Lopes, R. A.M. , Neves, K. B. , Carneiro, F. S. and Tostes, R. C. (2012) Testosterone and vascular function in aging. Frontiers in Physiology, 3, 89. (doi: 10.3389/fphys.2012.00089) (PMID:22514541) (PMCID:PMC3322529)
Articles
Montezano, A. C. et al. (2023) SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication. Scientific Reports, 13, 14086. (doi: 10.1038/s41598-023-41115-3) (PMID:37640791) (PMCID:PMC10462711)
Morris, H. E., Neves, K. B. , Nilsen, M., Montezano, A. C., MacLean, M. R. and Touyz, R. M. (2023) Notch3/Hes5 induces vascular dysfunction in hypoxia-induced pulmonary hypertension through ER stress and redox-sensitive pathways. Hypertension, 80(8), pp. 1683-1696. (doi: 10.1161/hypertensionaha.122.20449) (PMID:37254738)
Sykes, R. A. et al. (2023) Vascular mechanisms of post-COVID-19 conditions: rho-kinase is a novel target for therapy. European Heart Journal: Cardiovascular Pharmacotherapy, 9(4), pp. 371-386. (doi: 10.1093/ehjcvp/pvad025) (PMID:37019821) (PMCID:PMC10236521)
Neves, K. B. , Alves‐Lopes, R. , Montezano, A. C. and Touyz, R. M. (2023) Role of PARP and TRPM2 in VEGF inhibitor‐induced vascular dysfunction. Journal of the American Heart Association, 12(4), e027769. (doi: 10.1161/JAHA.122.027769) (PMID:36802924) (PMCID:PMC10111475)
Rios, F. J. et al. (2022) TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt. Communications Biology, 5, 746. (doi: 10.1038/s42003-022-03715-z) (PMID:35882956) (PMCID:PMC9325869)
Mirabito Colafella, K. M. et al. (2022) Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage. Clinical Science, 136(9), pp. 675-694. (doi: 10.1042/CS20220182) (PMID:35441670) (PMCID:PMC9093150)
Camargo, L. L. et al. (2022) Central role of c-Src in NOX5- mediated redox signaling in vascular smooth muscle cells in human hypertension. Cardiovascular Research, 118(5), pp. 1359-1373. (doi: 10.1093/cvr/cvab171) (PMID:34320175) (PMCID:PMC8953456)
Neves, K. B. , Rios, F. J. , Sevilla-Montero, J., Montezano, A. C. and Touyz, R. M. (2022) Exosomes and the cardiovascular system: role in cardiovascular health and disease. Journal of Physiology, (doi: 10.1113/JP282054) (PMID:35306667) (Early Online Publication)
Alves-Lopes, R. et al. (2021) Selective inhibition of the C-domain of ACE (angiotensin-converting enzyme) combined with inhibition of NEP (neprilysin): a potential new therapy for hypertension. Hypertension, 78(3), pp. 604-616. (doi: 10.1161/HYPERTENSIONAHA.121.17041) (PMID:34304582) (PMCID:PMC8357049)
Da Silva, J. F. et al. (2021) Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation - implications in atherosclerosis. Clinical Science, 135(15), pp. 1845-1858. (doi: 10.1042/CS20210468) (PMID:34269800)
van Dorst, D. C.H., Dobbin, S. J.H. , Neves, K. B. , Herrmann, J., Herrmann, S. M., Versmissen, J., Mathijssen, R. H.J., Danser, A.H. J. and Lang, N. N. (2021) Hypertension and prohypertensive antineoplastic therapies in cancer patients. Circulation Research, 128(7), pp. 1040-1061. (doi: 10.1161/CIRCRESAHA.121.318051) (PMID:33793337) (PMCID:PMC8011349)
Cameron, A. C., Neves, K. B. , White, J., Touyz, R. M. and Lang, N. N. (2021) Reply: Cisplatin-associated aortic thrombosis: a review of cases reported to the FDA adverse event reporting system. JACC: CardioOncology, 3(1), p. 166. (doi: 10.1016/j.jaccao.2021.01.005)
Neves, K. B. , Morris, H., Alves-Lopes, R., Muir, K. W. , Moreton, F., Delles, C. , Montezano, A. C. and Touyz, R. M. (2021) Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO∕sGC∕cGMP pathway. Clinical Science, 135(6), pp. 753-773. (doi: 10.1042/CS20201412) (PMID:33681964)
Rossitto, G. et al. (2020) Reduced lymphatic reserve in heart failure with preserved ejection fraction. Journal of the American College of Cardiology, 76(24), pp. 2817-2829. (doi: 10.1016/j.jacc.2020.10.022) (PMID:33303070) (PMCID:PMC7724570)
Cameron, A. C. et al. (2020) Comprehensive characterisation of the vascular effects of cisplatin-based chemotherapy in patients with testicular cancer. JACC: CardioOncology, 2(3), pp. 443-455. (doi: 10.1016/j.jaccao.2020.06.004) (PMID:33043304) (PMCID:PMC7539369)
Rossitto, G. et al. (2020) Tissue sodium excess is not hypertonic and reflects extracellular volume expansion. Nature Communications, 11, 4222. (doi: 10.1038/s41467-020-17820-2) (PMID:32839436) (PMCID:PMC7445299)
Zou, Z.-G. et al. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. Clinical Science, 134(15), pp. 2019-2035. (doi: 10.1042/CS20200827) (PMID:32706027) (PMCID:PMC8299307)
Touyz, R. , Rios, F. , Alves-Lopes, R., Neves, K. B. , De Lucca Camargo, L. and Montezano, A. C. (2020) Oxidative stress: a unifying paradigm in hypertension. Canadian Journal of Cardiology, 36, pp. 659-670. (doi: 10.1016/j.cjca.2020.02.081) (PMID:32389339) (PMCID:PMC7225748)
Cameron, A. C., Welsh, P. , Neves, K. B. , Newby, D., Touyz, R. M. and Lang, N. (2020) Acute vascular effects of vascular endothelial growth factor inhibition in the forearm arterial circulation. Journal of Hypertension, 38(2), pp. 257-265. (doi: 10.1097/HJH.0000000000002230) (PMID:31449168) (PMCID:PMC7197298)
Alves-Lopes, R., Neves, K. B. , Anagnostopoulou, A., Rios, F. J. , Lacchini, S., Montezano, A. C. and Touyz, R. M. (2020) Crosstalk between vascular redox and calcium signaling in hypertension involves TRPM2 (Transient Receptor Potential Melastatin 2) cation channel. Hypertension, 75(1), pp. 139-149. (doi: 10.1161/hypertensionaha.119.13861) (PMID:31735084)
Morris, H., Neves, K. B. , Montezano, A. C., Maclean, M. R. and Touyz, R. (2019) Notch3 signaling and vascular remodeling in pulmonary arterial hypertension. Clinical Science, 133(24), pp. 2481-2498. (doi: 10.1042/CS20190835) (PMID:31868216) (PMCID:PMC6928565)
Neves, K. B. et al. (2019) ER stress and Rho kinase activation underlie the vasculopathy of CADASIL. JCI Insight, 4(23), e131344. (doi: 10.1172/jci.insight.131344) (PMID:31647781) (PMCID:PMC6962020)
Neves, K. B. and Touyz, R. M. (2019) Extracellular vesicles as biomarkers and biovectors in primary aldosteronism. Hypertension, 74(2), pp. 250-252. (doi: 10.1161/hypertensionaha.119.13088) (PMID:31230536)
Alves-Lopes, R., Neves, K. B. and Touyz, R. M. (2019) Muscarinic receptor type-3 (MR3) in hypertension and cholinergic-adrenergic crosstalk: genetic insights and potential for new antihypertensive targets. Canadian Journal of Cardiology, 35(5), pp. 555-557. (doi: 10.1016/j.cjca.2019.02.003) (PMID:30954389) (PMCID:PMC6499128)
Neves, K. B. , Rios, F. J. , Jones, R. , Evans, T. R. J. , Montezano, A. C. and Touyz, R. M. (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115(5), pp. 978-988. (doi: 10.1093/cvr/cvz021) (PMID:30753341) (PMCID:PMC6452312)
Neves, K. B. , Nguyen Dinh Cat, A., Alves-Lopes, R. , Harvey, K. Y., da Costa, R. M., Lobato, N. S., Montezano, A. C., Oliveira, A. M., Touyz, R. M. and Tostes, R. C. (2018) Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways. American Journal of Physiology: Heart and Circulatory Physiology, 315(6), H1851-H1860. (doi: 10.1152/ajpheart.00285.2018) (PMID:30216119) (PMCID:PMC6336978)
Neves, K. B. , Montezano, A. C., Alves-Lopes, R. , Bruder-Nascimento, T., Costa, R. M., Costa, R. S., Touyz, R. M. and Tostes, R. C. (2018) Upregulation of Nrf2 and decreased redox signaling contribute to renoprotective effects of chemerin receptor blockade in diabetic mice. International Journal of Molecular Sciences, 19(8), 2454. (doi: 10.3390/ijms19082454) (PMID:30126255) (PMCID:PMC6121242)
Montezano, A. C. et al. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), e009388. (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)
Montezano, A. C. et al. (2018) NADPH Oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)
Neves, K. B. , Rios, F. J. , Van Der Mey, L., Alves-Lopes, R. , Cameron, A. C., Volpe, M., Montezano, A. C., Savoia, C. and Touyz, R. M. (2018) VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71(4), pp. 638-647. (doi: 10.1161/HYPERTENSIONAHA.117.10490) (PMID:29483228)
Costa, R. M., Neves, K. B. , Tostes, R. C. and Lobato, N. S. (2018) Perivascular adipose tissue as a relevant fat depot for cardiovascular risk in obesity. Frontiers in Physiology, 9, 253. (doi: 10.3389/fphys.2018.00253)
Souza-Silva, L., Alves-Lopes, R. , Silva Miguez, J., Dela Justina, V., Neves, K. B. , Mestriner, F. L., Tostes, R. C., Giachini, F. R. and Lima, V. V. (2018) Glycosylation with O-linked β-N-acetylglucosamine (O-GlcNAc) induces vascular dysfunction via production of superoxide anion/reactive oxygen species. Canadian Journal of Physiology and Pharmacology, 96(3), pp. 232-240. (doi: 10.1139/cjpp-2017-0225) (PMID:28793197)
Carneiro, F. S., Alves-Lopes, R. , Neves, K. B. , Silva, M. A.B., Olivon, V. C., Ruginsk, S. G., Antunes-Rodrigues, J., Ramalho, L. N.Z. and Tostes, R. C. (2017) Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation. Asian Journal of Andrology, 19(5), pp. 526-532. (doi: 10.4103/1008-682X.173935) (PMID:27391248) (PMCID:PMC5566844)
Alves-Lopes, R. , Neves, K. B. , Montezano, A., Harvey, A., Carneiro, F. S., Touyz, R. and Tostes, R. C. (2016) Internal pudendal artery dysfunction in diabetes is mediated by Nox1-derived Ros, NRF2- and RHO kinase-depedent mechanisms. Hypertension, 68(4), pp. 1056-1064. (doi: 10.1161/HYPERTENSIONAHA.116.07518) (PMID:27528061)
Lopes, R. , Neves, K. , Tostes, R., Montezano, A. and Touyz, R. (2015) Downregulation of nuclear factor erythroid 2–related factor and associated antioxidant genes contributes to redox-sensitive vascular dysfunction in hypertension. Hypertension, 2015(66), pp. 1240-1250. (doi: 10.1161/hypertensionaha.115.06163) (PMID:26503970)
Silva, M. A. B. et al. (2015) Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus. Clinical Science, 129(7), pp. 533-545. (doi: 10.1042/cs20140758) (PMID:25967696)
Lopes, R. A. M. , Neves, K. B. , Pestana, C. R., Queiroz, A. L., Zanotto, C. Z., Chignalia, A. Z., Valim, Y. M., Silveira, L. R., Curti, C. and Tostes, R. C. (2014) Testosterone induces apoptosis in vascular smooth muscle cells via extrinsic apoptotic pathway with mitochondria-generated reactive oxygen species involvement. American Journal of Physiology: Heart and Circulatory Physiology, 306(11), H1485-H1494. (doi: 10.1152/ajpheart.00809.2013) (PMID:24658017)
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Book Sections
Neves, K. B. and Touyz, R. M. (2019) Vascular signaling. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 83-91. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_8)
Montezano, A. C., Lopes, R. A.M. , Neves, K. B. , Rios, F. and Touyz, R. M. (2017) Isolation and culture of vascular smooth muscle cells from small and large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 349-354. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_27)
Montezano, A. C., Neves, K. B. , Lopes, R. A.M. and Rios, F. (2017) Isolation and culture of endothelial cells from large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 345-348. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_26)
