Dr John Mercer

  • Senior Lecturer (Institute of Cardiovascular & Medical Sciences)
  • Associate (School of Life Sciences)

telephone: 01413302929
email: John.Mercer@glasgow.ac.uk

Bhf, Cardiovascular Research Centre, G12 8ta

ORCID iDhttps://orcid.org/0000-0002-3204-7511

Biography

John is a Senior Lecturer (tenured) at the Institute of Cardiovascular & Medicine Science (ICAMS) at the University of Glasgow. His basic research projects investigate the role of nuclear DNA damage and mitochondrial dysfunction in transgenic models of atherosclerosis with the goal of developing new translational therapies. In addition, he has cross disciplinary and applied research with the School of Engineering to develop new types of biomedical devices. In particular this is working towards prototyping, validating and eventually commercialising a self-reporting SMART cardiovascular device.

John graduated from Oxford Brookes with a BSc (Hons) in Cell and Molecular biology in 1995 and then undertook an MPhil/PhD investigating the emerging role of p53 in radiation induced mutations in thyroid cancer at the radiobiology labs at Berkeley, graduating from the University of St Andrews in 2000.

For his postdoctoral research, John joined the University of Cambridge, Department of Medicine at Addenbrooke’s hospital. At this British Heart Foundation (BHF) Cardiovascular Research Centre he investigated the inducible role of p53 in vascular smooth muscle cell (vsmc) biology, with a significant emphasis of developing transgenic mouse models of disease. In 2003 John won a British Atherosclerosis Society (BAS) Young Investigator award and an International travel award in 2004.  His research led to further investigations into the upstream DNA damage repair kinase, Ataxia Talengectasia (ATM) in the ApoE model of atherosclerosis. This work was supported by BHF program grants, and as well as investigating the mechanism of vsmc senescence and nuclear DNA damage, it also highlighted the emerging role mitochondrial DNA damage in vsmc bioenergetics. Collaborations with Dr Mike Murphy at the MRC Mitochondrial Biology Unit on the role of mitochondrial targeted antioxidants, such as MitoQ and the role of DNA damage in promoting metabolic syndrome with Prof.Toni-Vidal Puig led to him being awarded the European Atherosclerosis Society (EAS) Young Investigator Award in Gothenburg in 2011.

As Senior Lecturer his goal is to exploit this area of investigation and John has developed a strong multidisciplinary team in collaboration with Dr Steve Neale from the James Watt Nanofabrication Centre (JWNC), Glasgow.  The group includes vascular biologists, micro and nano engineers and clinical leads from the NHS.  John is based at the British Heart Foundation Glasgow Cardiovascular Research Centre (BHF GCRC).  This is a BHF Translational Centre of Research Excellence with a focus on primary and secondary prevention of cardiovascular disease. To help accelerate development of transformative technologies related to cardiovascular disease John was awarded a Lord Kelvin Adam Smith PhD scholarship in 2015 and an EPSRC-DTP PhD scholarship in 2019.

Research interests

Member: Vascular Research 

Research:  Role of mitochondrial dysfunction in Atherosclerosis

Research Interests:  Role of mitochondrial dysfunction in Atherosclerosis and Development of a SMART stent for cardiovascular diseases.

Reviewer

British Heart foundation, Medical research Council, Biochemistry Society

Hypertension Journal, Clinical Sciences, British Journal of Pharmacology

FEBS Journal, Biosciences Reports, Oncotaget, BMC Series. 

Funding:

2018-2021 EPSRC-DTP PhD scholarship ~ £160,000.

2019 - MRC - Confidence in Concept –Development  of smart vascular device £100,000 University of Edinburgh  (Co-I).

2017-2018 Chief Scientific Officer CSO Catalyst grant -  £18,848.

2016-2017 University of Glasgow translational seed funding £20,000.

2015-2019 LKAS - Lord Kelvin Adam Smith PhD Scholarship ~ £160,000.

 

 

 

Publications

List by: Type | Date

Jump to: 2020 | 2019 | 2018 | 2016 | 2015 | 2014 | 2013 | 2012 | 2010 | 2008 | 2007 | 2006 | 2005 | 2001
Number of items: 25.

2020

Bussooa, A., Hoare, D., Kirimi, M. T., Mitra, S., Mirzai, N., Neale, S. L. and Mercer, J. (2020) Impedimetric detection and electromediated apoptosis of vascular smooth muscle using microfabricated biosensors for diagnosis and therapeutic treatment in cardiovascular diseases. Advanced Science, (doi: 10.1002/advs.201902999) (Early Online Publication)

Liang, X., Fan, H., Mercer, J. and Heidari, H. (2020) A Delay-Based Neuromorphic Processor for Arrhythmias Diagnosis. In: 2020 IEEE International Symposium on Circuits and Systems, Seville, Spain, 17-20 May 2020, (Accepted for Publication)

2019

Hoare, D., Bussooa, A., Neale, S. , Mirzai, N. and Mercer, J. (2019) The future of cardiovascular stents: bioresorbable and integrated biosensor technology. Advanced Science, 6(20), 1900856. (doi: 10.1002/advs.201900856) (PMID:31637160) (PMCID:PMC6794628)

Mercer, J. and Guzik, T. J. (2019) Atherosclerosis. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 215-228. ISBN 9783030164805 (doi:10.1007/978-3-030-16481-2_20)

2018

Bussooa, A., Neale, S. and Mercer, J. R. (2018) Future of smart cardiovascular implants. Sensors, 18(7), 2008. (doi: 10.3390/s18072008) (PMID:29932154) (PMCID:PMC6068883)

Docherty, C. K., Carswell, A., Friel, E. and Mercer, J. R. (2018) Impaired mitochondrial respiration in human carotid plaque atherosclerosis: a potential role for Pink1 in vascular smooth muscle cell energetics. Atherosclerosis, 268, pp. 1-11. (doi: 10.1016/j.atherosclerosis.2017.11.009) (PMID:29156421)

2016

Docherty, C. K., Salt, I. P. and Mercer, J. R. (2016) Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells. Stem Cell Research and Therapy, 7(1), 78. (doi: 10.1186/s13287-016-0323-2)

2015

Gray, K. L., Kumar, S. V., Figg, N., Harrison, J., Baker, L., Mercer, J. R. , Littlewood, T. D. and Bennett, M. R. (2015) Effects of DNA damage in smooth muscle cells in atherosclerosis. Circulation Research, 116, pp. 816-826. (doi: 10.1161/CIRCRESAHA.116.304921)

2014

Mercer, J. R. (2014) Mitochondrial bioenergetics and therapeutic intervention in cardiovascular disease. Pharmacology and Therapeutics, 141(1), pp. 13-20. (doi: 10.1016/j.pharmthera.2013.07.011) (PMID:23911986)

Zhongzhao, T., He, J., Sadat, U., Mercer, J.R. , Xiaoyan, W., Bahaei, N.S., Thomas, O.M. and Gillard, J.H. (2014) How does juxtaluminal calcium affect critical mechanical conditions in carotid atherosclerotic plaque? An exploratory study. IEEE Transactions on Biomedical Engineering, 61(1), pp. 35-40. (doi: 10.1109/TBME.2013.2275078) (PMID:23912462)

2013

Yu, E. et al. (2013) Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes, and correlates with higher risk plaques in humans. Circulation, 128, pp. 702-712. (doi: 10.1161/CIRCULATIONAHA.113.002271)

Gorenne, I., Kumar, S., Gray, K., Figg, N., Yu, H., Mercer, J.R. and Bennett, M. (2013) Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis. Circulation, 127(3), pp. 386-396. (doi: 10.1161/CIRCULATIONAHA.112.124404)

2012

Mercer, J.R. , Gray, K., Figg, N., Kumar, S. and Bennett, M.R. (2012) The methyl xanthine caffeine inhibits DNA damage signaling and reactive species and reduces atherosclerosis in ApoE-/- mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(10), pp. 2461-2467. (doi: 10.1161/ATVBAHA.112.251322)

Blackmore, H.L., Piekarz, A.V., Fernandez‑Twinn, D.S., Mercer, J.R. , Figg, N., Bennett, M. and Ozanne, S.E. (2012) Poor maternal nutrition programmes a pro-atherosclerotic phenotype in ApoE−/−mice. Clinical Science, 123(4), pp. 251-257. (doi: 10.1042/CS20110487)

Yu, E., Mercer, J.R. and Bennett, M. (2012) Mitochondria in vascular disease. Cardiovascular Research, 95(2), pp. 173-182. (doi: 10.1093/cvr/cvs111) (PMID:22392270)

Mercer, J.R. , Yu, E., Figg, N., Cheng, K., Prime, T.A., Griffin, J.L., Masoodi, M., Vidal-Puig, A., Murphy, M.P. and Bennett, M.R. (2012) The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/–/ApoE–/– mice. Free Radical Biology and Medicine, 52(5), pp. 841-849. (doi: 10.1016/j.freeradbiomed.2011.11.026)

2010

Mercer, J.R. , Cheng, K.-K., Figg, N., Gorenne, I., Mahmoudi, M., Griffin, J., Vidal-Puig, A., Logan, A., Murphy, M.P. and Bennett, M. (2010) DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circulation Research, 107(8), pp. 1021-1031. (doi: 10.1161/CIRCRESAHA.110.218966)

2008

Mahmoudi, M., Gorenne, I., Mercer, J.R. , Figg, N., Littlewood, T. and Bennett, M. (2008) Statins use a novel nijmegen breakage syndrome-1-dependent pathway to accelerate DNA repair in vascular smooth muscle cells. Circulation Research, 103(7), pp. 717-725. (doi: 10.1161/CIRCRESAHA.108.182899)

2007

Kavurma, M.M., Figg, N., Bennett, M.R., Mercer, J.R. , Khachigian, L.M. and Littlewood, T.D. (2007) Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment. Biochemical Journal, 407(1), p. 79. (doi: 10.1042/BJ20070380)

Mercer, J.R. , Mahmoudi, M. and Bennett, M. (2007) DNA damage, p53, apoptosis and vascular disease. Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis, 621(1-2), pp. 75-86. (doi: 10.1016/j.mrfmmm.2007.02.011)

Stoneman, V., Braganza, D., Figg, N., Mercer, J.R. , Lang, R., Goddard, M. and Bennett, M. (2007) Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques. Circulation Research, 100(6), pp. 884-893. (doi: 10.1161/01.RES.0000260802.75766.00)

2006

Mercer, J.R. and Bennett, M. (2006) The role of p53 in atherosclerosis. Cell Cycle, 5(17), pp. 1907-1909. (doi: 10.4161/cc.5.17.3166)

Mahmoudi, M., Mercer, J.R. and Bennett, M. (2006) DNA damage and repair in atherosclerosis. Cardiovascular Research, 71(2), pp. 259-268. (doi: 10.1016/j.cardiores.2006.03.002)

2005

Mercer, J.R. , Figg, N., Stoneman, V., Braganza, D. and Bennett, M.R. (2005) Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice. Circulation Research, 96(6), pp. 667-674. (doi: 10.1161/01.RES.0000161069.15577.ca)

2001

McCarthy, N., Mercer, J.R. and Bennett, M. (2001) Apoptotic proteins: p53 and c-myc related pathways. Cardiology Clinics, 19(1), pp. 75-89. (doi: 10.1016/S0733-8651(05)70196-X)

This list was generated on Fri Aug 14 14:11:00 2020 BST.
Number of items: 25.

Articles

Bussooa, A., Hoare, D., Kirimi, M. T., Mitra, S., Mirzai, N., Neale, S. L. and Mercer, J. (2020) Impedimetric detection and electromediated apoptosis of vascular smooth muscle using microfabricated biosensors for diagnosis and therapeutic treatment in cardiovascular diseases. Advanced Science, (doi: 10.1002/advs.201902999) (Early Online Publication)

Hoare, D., Bussooa, A., Neale, S. , Mirzai, N. and Mercer, J. (2019) The future of cardiovascular stents: bioresorbable and integrated biosensor technology. Advanced Science, 6(20), 1900856. (doi: 10.1002/advs.201900856) (PMID:31637160) (PMCID:PMC6794628)

Bussooa, A., Neale, S. and Mercer, J. R. (2018) Future of smart cardiovascular implants. Sensors, 18(7), 2008. (doi: 10.3390/s18072008) (PMID:29932154) (PMCID:PMC6068883)

Docherty, C. K., Carswell, A., Friel, E. and Mercer, J. R. (2018) Impaired mitochondrial respiration in human carotid plaque atherosclerosis: a potential role for Pink1 in vascular smooth muscle cell energetics. Atherosclerosis, 268, pp. 1-11. (doi: 10.1016/j.atherosclerosis.2017.11.009) (PMID:29156421)

Docherty, C. K., Salt, I. P. and Mercer, J. R. (2016) Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells. Stem Cell Research and Therapy, 7(1), 78. (doi: 10.1186/s13287-016-0323-2)

Gray, K. L., Kumar, S. V., Figg, N., Harrison, J., Baker, L., Mercer, J. R. , Littlewood, T. D. and Bennett, M. R. (2015) Effects of DNA damage in smooth muscle cells in atherosclerosis. Circulation Research, 116, pp. 816-826. (doi: 10.1161/CIRCRESAHA.116.304921)

Mercer, J. R. (2014) Mitochondrial bioenergetics and therapeutic intervention in cardiovascular disease. Pharmacology and Therapeutics, 141(1), pp. 13-20. (doi: 10.1016/j.pharmthera.2013.07.011) (PMID:23911986)

Zhongzhao, T., He, J., Sadat, U., Mercer, J.R. , Xiaoyan, W., Bahaei, N.S., Thomas, O.M. and Gillard, J.H. (2014) How does juxtaluminal calcium affect critical mechanical conditions in carotid atherosclerotic plaque? An exploratory study. IEEE Transactions on Biomedical Engineering, 61(1), pp. 35-40. (doi: 10.1109/TBME.2013.2275078) (PMID:23912462)

Yu, E. et al. (2013) Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes, and correlates with higher risk plaques in humans. Circulation, 128, pp. 702-712. (doi: 10.1161/CIRCULATIONAHA.113.002271)

Gorenne, I., Kumar, S., Gray, K., Figg, N., Yu, H., Mercer, J.R. and Bennett, M. (2013) Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis. Circulation, 127(3), pp. 386-396. (doi: 10.1161/CIRCULATIONAHA.112.124404)

Mercer, J.R. , Gray, K., Figg, N., Kumar, S. and Bennett, M.R. (2012) The methyl xanthine caffeine inhibits DNA damage signaling and reactive species and reduces atherosclerosis in ApoE-/- mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(10), pp. 2461-2467. (doi: 10.1161/ATVBAHA.112.251322)

Blackmore, H.L., Piekarz, A.V., Fernandez‑Twinn, D.S., Mercer, J.R. , Figg, N., Bennett, M. and Ozanne, S.E. (2012) Poor maternal nutrition programmes a pro-atherosclerotic phenotype in ApoE−/−mice. Clinical Science, 123(4), pp. 251-257. (doi: 10.1042/CS20110487)

Yu, E., Mercer, J.R. and Bennett, M. (2012) Mitochondria in vascular disease. Cardiovascular Research, 95(2), pp. 173-182. (doi: 10.1093/cvr/cvs111) (PMID:22392270)

Mercer, J.R. , Yu, E., Figg, N., Cheng, K., Prime, T.A., Griffin, J.L., Masoodi, M., Vidal-Puig, A., Murphy, M.P. and Bennett, M.R. (2012) The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/–/ApoE–/– mice. Free Radical Biology and Medicine, 52(5), pp. 841-849. (doi: 10.1016/j.freeradbiomed.2011.11.026)

Mercer, J.R. , Cheng, K.-K., Figg, N., Gorenne, I., Mahmoudi, M., Griffin, J., Vidal-Puig, A., Logan, A., Murphy, M.P. and Bennett, M. (2010) DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circulation Research, 107(8), pp. 1021-1031. (doi: 10.1161/CIRCRESAHA.110.218966)

Mahmoudi, M., Gorenne, I., Mercer, J.R. , Figg, N., Littlewood, T. and Bennett, M. (2008) Statins use a novel nijmegen breakage syndrome-1-dependent pathway to accelerate DNA repair in vascular smooth muscle cells. Circulation Research, 103(7), pp. 717-725. (doi: 10.1161/CIRCRESAHA.108.182899)

Kavurma, M.M., Figg, N., Bennett, M.R., Mercer, J.R. , Khachigian, L.M. and Littlewood, T.D. (2007) Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment. Biochemical Journal, 407(1), p. 79. (doi: 10.1042/BJ20070380)

Mercer, J.R. , Mahmoudi, M. and Bennett, M. (2007) DNA damage, p53, apoptosis and vascular disease. Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis, 621(1-2), pp. 75-86. (doi: 10.1016/j.mrfmmm.2007.02.011)

Stoneman, V., Braganza, D., Figg, N., Mercer, J.R. , Lang, R., Goddard, M. and Bennett, M. (2007) Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques. Circulation Research, 100(6), pp. 884-893. (doi: 10.1161/01.RES.0000260802.75766.00)

Mercer, J.R. and Bennett, M. (2006) The role of p53 in atherosclerosis. Cell Cycle, 5(17), pp. 1907-1909. (doi: 10.4161/cc.5.17.3166)

Mahmoudi, M., Mercer, J.R. and Bennett, M. (2006) DNA damage and repair in atherosclerosis. Cardiovascular Research, 71(2), pp. 259-268. (doi: 10.1016/j.cardiores.2006.03.002)

Mercer, J.R. , Figg, N., Stoneman, V., Braganza, D. and Bennett, M.R. (2005) Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice. Circulation Research, 96(6), pp. 667-674. (doi: 10.1161/01.RES.0000161069.15577.ca)

McCarthy, N., Mercer, J.R. and Bennett, M. (2001) Apoptotic proteins: p53 and c-myc related pathways. Cardiology Clinics, 19(1), pp. 75-89. (doi: 10.1016/S0733-8651(05)70196-X)

Book Sections

Mercer, J. and Guzik, T. J. (2019) Atherosclerosis. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 215-228. ISBN 9783030164805 (doi:10.1007/978-3-030-16481-2_20)

Conference Proceedings

Liang, X., Fan, H., Mercer, J. and Heidari, H. (2020) A Delay-Based Neuromorphic Processor for Arrhythmias Diagnosis. In: 2020 IEEE International Symposium on Circuits and Systems, Seville, Spain, 17-20 May 2020, (Accepted for Publication)

This list was generated on Fri Aug 14 14:11:00 2020 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Design and fabrication of a remote controlled wireless impedance sensing unit for a new cardiovascular medical device.
    Chief Scientist Office
    2017 - 2018
     

Teaching

I am coordinator of the basic science component of the new 2019 MSc Cardiovascular Sciences postgraduate degree.  In semester 1 the program covers evidence based biomedical research method, clinical and research laboratory skills, clinical aspects of cardiovascular disease (CVD) and diabetes.  In semester 2 the course covers the basic science of CVD, tissues, cells and signaling and includes a 12 week laboratory based research project.

In addition I take students for basic science research projects across a number of undergraduate and masters programs including the integrated mammalian biology course (IMB-MRes).  I also contribute to a number of undergraduate lecture programs including Year 2 SSC research methods, Year 3 Human biology and Physiology - mitochondria in health, Year 4, Molecular basis of disease and the new Level 4 Mitochondrial option.  I also coordinate the new Level 4 Biochemistry Mitochondrial lab practical.

I am a fellow of the higher education authority (FHEA) and STEM Ambassador to promote science technology, engineering and maths at primary and secondary school level.  I am also an ongoing member of the British and European Atherosclerosis Societies.