Dr Augusto Montezano
- Honorary Research Fellow (School of Cardiovascular & Metabolic Health)
email:
Augusto.Montezano@glasgow.ac.uk
BHF GCRC - ICAMS, 126 University Place, G12 8TA
Research interests
Member:
Publications
2024
Tobias, E. S. et al. (2024) SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis. Endocrine, (doi: 10.1007/s12020-024-03701-x) (PMID:38400880) (Early Online Publication)
2023
Lucas-Herald, A. K. et al. (2023) Effects of sex hormones on vascular reactivity in boys with hypospadias. Journal of Clinical Endocrinology and Metabolism, (doi: 10.1210/clinem/dgad525) (PMID:37672642) (Early Online Publication)
Montezano, A. C. et al. (2023) SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication. Scientific Reports, 13, 14086. (doi: 10.1038/s41598-023-41115-3) (PMID:37640791) (PMCID:PMC10462711)
Morris, H. E., Neves, K. B. , Nilsen, M., Montezano, A. C., MacLean, M. R. and Touyz, R. M. (2023) Notch3/Hes5 induces vascular dysfunction in hypoxia-induced pulmonary hypertension through ER stress and redox-sensitive pathways. Hypertension, 80(8), pp. 1683-1696. (doi: 10.1161/hypertensionaha.122.20449) (PMID:37254738)
Sykes, R. A. et al. (2023) Vascular mechanisms of post-COVID-19 conditions: rho-kinase is a novel target for therapy. European Heart Journal: Cardiovascular Pharmacotherapy, 9(4), pp. 371-386. (doi: 10.1093/ehjcvp/pvad025) (PMID:37019821) (PMCID:PMC10236521)
Neves, K. B. , Alves‐Lopes, R. , Montezano, A. C. and Touyz, R. M. (2023) Role of PARP and TRPM2 in VEGF inhibitor‐induced vascular dysfunction. Journal of the American Heart Association, 12(4), e027769. (doi: 10.1161/JAHA.122.027769) (PMID:36802924) (PMCID:PMC10111475)
2022
Rios, F. J. et al. (2022) TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt. Communications Biology, 5, 746. (doi: 10.1038/s42003-022-03715-z) (PMID:35882956) (PMCID:PMC9325869)
Lucas-Herald, A. K. et al. (2022) Vascular dysfunction and increased cardiovascular risk in hypospadias. European Heart Journal, 43(19), pp. 1832-1845. (doi: 10.1093/eurheartj/ehac112) (PMID:35567552) (PMCID:PMC9113289)
Mirabito Colafella, K. M. et al. (2022) Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage. Clinical Science, 136(9), pp. 675-694. (doi: 10.1042/CS20220182) (PMID:35441670) (PMCID:PMC9093150)
Camargo, L. L. et al. (2022) Central role of c-Src in NOX5- mediated redox signaling in vascular smooth muscle cells in human hypertension. Cardiovascular Research, 118(5), pp. 1359-1373. (doi: 10.1093/cvr/cvab171) (PMID:34320175) (PMCID:PMC8953456)
Neves, K. B. , Rios, F. J. , Sevilla-Montero, J., Montezano, A. C. and Touyz, R. M. (2022) Exosomes and the cardiovascular system: role in cardiovascular health and disease. Journal of Physiology, (doi: 10.1113/JP282054) (PMID:35306667) (Early Online Publication)
Connelly, P. J. , Casey, H., Montezano, A. C., Touyz, R. M. and Delles, C. (2022) Sex steroids receptors, hypertension and vascular ageing. Journal of Human Hypertension, 36(2), pp. 120-125. (doi: 10.1038/s41371-021-00576-7) (PMID:34230581) (PMCID:PMC8850193)
2021
Mahindra, A. et al. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16(11), e0260283. (doi: 10.1371/journal.pone.0260283) (PMID:34793553) (PMCID:PMC8601423)
Touyz, R. M. et al. (2021) Cardiovascular and renal risk factors and complications associated with COVID-19. CJC Open, 3(10), pp. 1257-1272. (doi: 10.1016/j.cjco.2021.05.020) (PMID:34151246) (PMCID:PMC8205551)
Alves-Lopes, R. et al. (2021) Selective inhibition of the C-domain of ACE (angiotensin-converting enzyme) combined with inhibition of NEP (neprilysin): a potential new therapy for hypertension. Hypertension, 78(3), pp. 604-616. (doi: 10.1161/HYPERTENSIONAHA.121.17041) (PMID:34304582) (PMCID:PMC8357049)
Da Silva, J. F. et al. (2021) Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation - implications in atherosclerosis. Clinical Science, 135(15), pp. 1845-1858. (doi: 10.1042/CS20210468) (PMID:34269800)
Rossitto, G. et al. (2021) High sodium intake, glomerular hyperfiltration and protein catabolism in patients with essential hypertension. Cardiovascular Research, 117(5), pp. 1372-1381. (doi: 10.1093/cvr/cvaa205) (PMID:33053160) (PMCID:PMC8064429)
Griendling, K. K., Camargo, L. L., Rios, F. , Alves-Lopes, R., Montezano, A. C. and Touyz, R. M. (2021) Oxidative stress and hypertension. Circulation Research, 128(7), pp. 993-1020. (doi: 10.1161/CIRCRESAHA.121.318063) (PMID:33793335)
Neves, K. B. , Morris, H., Alves-Lopes, R., Muir, K. W. , Moreton, F., Delles, C. , Montezano, A. C. and Touyz, R. M. (2021) Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO∕sGC∕cGMP pathway. Clinical Science, 135(6), pp. 753-773. (doi: 10.1042/CS20201412) (PMID:33681964)
Kuriakose, J., Montezano, A. C. and Touyz, R. M. (2021) ACE-2/Ang (1-7)/Mas axis and the vascular system: vasoprotection to COVID-19-associated vascular disease. Clinical Science, 135(2), pp. 387-407. (doi: 10.1042/CS20200480) (PMID:33511992) (PMCID:PMC7846970)
2020
Anagnostopoulou, A., Camargo, L. L. , Rodrigues, D., Montezano, A. C. and Touyz, R. M. (2020) Importance of cholesterol-rich microdomains in the regulation of Nox isoforms and redox signaling in human vascular smooth muscle cells. Scientific Reports, 10, 17818. (doi: 10.1038/s41598-020-73751-4) (PMID:33082354) (PMCID:PMC7575553)
Cameron, A. C. et al. (2020) Comprehensive characterisation of the vascular effects of cisplatin-based chemotherapy in patients with testicular cancer. JACC: CardioOncology, 2(3), pp. 443-455. (doi: 10.1016/j.jaccao.2020.06.004) (PMID:33043304) (PMCID:PMC7539369)
Zhao, G.-J. et al. (2020) Ca2+-dependent NOX5 (NADPH oxidase 5) exaggerates cardiac hypertrophy through reactive oxygen species production. Hypertension, 76(3), pp. 827-838. (doi: 10.1161/HYPERTENSIONAHA.120.15558)
Rossitto, G. et al. (2020) Tissue sodium excess is not hypertonic and reflects extracellular volume expansion. Nature Communications, 11, 4222. (doi: 10.1038/s41467-020-17820-2) (PMID:32839436) (PMCID:PMC7445299)
Zou, Z.-G. et al. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. Clinical Science, 134(15), pp. 2019-2035. (doi: 10.1042/CS20200827) (PMID:32706027) (PMCID:PMC8299307)
Touyz, R. , Rios, F. , Alves-Lopes, R., Neves, K. B. , De Lucca Camargo, L. and Montezano, A. C. (2020) Oxidative stress: a unifying paradigm in hypertension. Canadian Journal of Cardiology, 36, pp. 659-670. (doi: 10.1016/j.cjca.2020.02.081) (PMID:32389339) (PMCID:PMC7225748)
Bautista-Niño, P. K. et al. (2020) Local endothelial DNA repair defect causes aging-resembling endothelial-specific dysfunction. Clinical Science, 134(7), pp. 727-746. (doi: 10.1042/cs20190124) (PMID:32202295)
Rios, F. J. , Montezano, A. C. and Touyz, R. M. (2020) Lessons learned from RAG-1-deficient mice in hypertension. Hypertension, 75(4), pp. 935-937. (doi: 10.1161/hypertensionaha.119.14406) (PMID:32078397)
Rios, F. J. et al. (2020) Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis. Cardiovascular Research, 116(3), pp. 721-735. (doi: 10.1093/cvr/cvz164) (PMID:31250885) (PMCID:PMC7252442)
Alves-Lopes, R., Neves, K. B. , Anagnostopoulou, A., Rios, F. J. , Lacchini, S., Montezano, A. C. and Touyz, R. M. (2020) Crosstalk between vascular redox and calcium signaling in hypertension involves TRPM2 (Transient Receptor Potential Melastatin 2) cation channel. Hypertension, 75(1), pp. 139-149. (doi: 10.1161/hypertensionaha.119.13861) (PMID:31735084)
2019
Morris, H., Neves, K. B. , Montezano, A. C., Maclean, M. R. and Touyz, R. (2019) Notch3 signaling and vascular remodeling in pulmonary arterial hypertension. Clinical Science, 133(24), pp. 2481-2498. (doi: 10.1042/CS20190835) (PMID:31868216) (PMCID:PMC6928565)
Neves, K. B. et al. (2019) ER stress and Rho kinase activation underlie the vasculopathy of CADASIL. JCI Insight, 4(23), e131344. (doi: 10.1172/jci.insight.131344) (PMID:31647781) (PMCID:PMC6962020)
Touyz, R. M. , Anagnostopoulou, A., Rios, F. , Montezano, A. C. and De Lucca Camargo, L. (2019) NOX5: molecular biology and pathophysiology. Experimental Physiology, 104(5), pp. 605-616. (doi: 10.1113/EP086204) (PMID:30801870) (PMCID:PMC6519284)
Neves, K. B. , Rios, F. J. , Jones, R. , Evans, T. R. J. , Montezano, A. C. and Touyz, R. M. (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115(5), pp. 978-988. (doi: 10.1093/cvr/cvz021) (PMID:30753341) (PMCID:PMC6452312)
Zou, Z.-G., Rios, F. J. , Montezano, A. C. and Touyz, R. M. (2019) TRPM7, magnesium and signaling. International Journal of Molecular Sciences, 20(8), 1877. (doi: 10.3390/ijms20081877) (PMID:30995736) (PMCID:PMC6515203)
Bruder-Nascimento, T., Callera, G. E., Montezano, A. C., Belin de Chantemele, E. J., Tostes, R. C. and Touyz, R. M. (2019) Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress. Life Sciences, 221, pp. 29-34. (doi: 10.1016/j.lfs.2019.01.043) (PMID:30721707) (PMCID:PMC6686670)
Touyz, R. M. , Anagnostopoulou, A., De Lucca Camargo, L. , Rios, F. J. and Montezano, A. C. (2019) Vascular biology of superoxide-generating NADPH oxidase 5 (Nox5)- implications in hypertension and cardiovascular disease. Antioxidants and Redox Signaling, 30(7), pp. 1027-1040. (doi: 10.1089/ars.2018.7583) (PMID:30334629) (PMCID:PMC6354601)
Alves-Lopes, R. , Touyz, R. M. and Montezano, A. C. (2019) Cell biology of vessels. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 23-30. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_3)
Rios, F. J. , Touyz, R. M. , Montezano, A. C. and Burger, D. (2019) Microparticles and exosomes in cell-cell communication. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 159-168. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_15)
2018
Ford, T. J. et al. (2018) Systemic microvascular dysfunction in microvascular and vasospastic angina. European Heart Journal, 39(46), pp. 4086-4097. (doi: 10.1093/eurheartj/ehy529) (PMID:30165438) (PMCID:PMC6284165)
Neves, K. B. , Nguyen Dinh Cat, A., Alves-Lopes, R. , Harvey, K. Y., da Costa, R. M., Lobato, N. S., Montezano, A. C., Oliveira, A. M., Touyz, R. M. and Tostes, R. C. (2018) Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways. American Journal of Physiology: Heart and Circulatory Physiology, 315(6), H1851-H1860. (doi: 10.1152/ajpheart.00285.2018) (PMID:30216119) (PMCID:PMC6336978)
Neves, K. B. , Montezano, A. C., Alves-Lopes, R. , Bruder-Nascimento, T., Costa, R. M., Costa, R. S., Touyz, R. M. and Tostes, R. C. (2018) Upregulation of Nrf2 and decreased redox signaling contribute to renoprotective effects of chemerin receptor blockade in diabetic mice. International Journal of Molecular Sciences, 19(8), 2454. (doi: 10.3390/ijms19082454) (PMID:30126255) (PMCID:PMC6121242)
De Lucca Camargo, L. et al. (2018) Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72(1), pp. 235-246. (doi: 10.1161/HYPERTENSIONAHA.118.10824) (PMID:29844144) (PMCID:PMC6004120)
Montezano, A. C. et al. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), e009388. (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)
Neves, K. B. , Rios, F. J. , Van Der Mey, L., Alves-Lopes, R. , Cameron, A. C., Volpe, M., Montezano, A. C., Savoia, C. and Touyz, R. M. (2018) VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71(4), pp. 638-647. (doi: 10.1161/HYPERTENSIONAHA.117.10490) (PMID:29483228)
Touyz, R. M. , Alves-Lopes, R. , Rios, F. J. , De Lucca Camargo, L. , Anagnostopoulou, A., Arner, A. and Montezano, A. C. (2018) Vascular smooth muscle contraction in hypertension. Cardiovascular Research, 114(4), pp. 529-539. (doi: 10.1093/cvr/cvy023) (PMID:29394331) (PMCID:PMC5852517)
Nguyen Dinh Cat, A. et al. (2018) Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling. Scientific Reports, 8, 2952. (doi: 10.1038/s41598-018-21087-5) (PMID:29440699) (PMCID:PMC5811612)
Touyz, R. M. and Montezano, A. C. (2018) Angiotensin-(1–7) and vascular function: the clinical context. Hypertension, 71(1), pp. 68-69. (doi: 10.1161/HYPERTENSIONAHA.117.10406) (PMID:29203630)
2017
Silva, S. D., Jara, Z. P., Peres, R., Lima, L. S., Scavone, C., Montezano, A. C., Touyz, R. M. , Casarini, D. E. and Michelini, L. C. (2017) Temporal changes in cardiac oxidative stress, inflammation and remodeling induced by exercise in hypertension: Role for local angiotensin II reduction. PLoS ONE, 12(12), e0189535. (doi: 10.1371/journal.pone.0189535) (PMID:29232407) (PMCID:PMC5726656)
Skiba, D.S. et al. (2017) Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis. British Journal of Pharmacology, 174(22), pp. 4055-4069. (doi: 10.1111/bph.13685) (PMID:27935022) (PMCID:PMC5659999)
Hood, K. Y., Mair, K. M., Harvey, A. P., Montezano, A. C., Touyz, R. M. and MacLean, M. R. (2017) Serotonin signaling through the 5-HT1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(7), pp. 1361-1370. (doi: 10.1161/ATVBAHA.116.308929) (PMID:28473438) (PMCID:PMC5478178)
Lucas-Herald, A. K. , Alves-Lopes, R. , Montezano, A. C., Ahmed, S. F. and Touyz, R. M. (2017) Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications. Clinical Science, 131(13), pp. 1405-1418. (doi: 10.1042/CS20170090) (PMID:28645930) (PMCID:PMC5736922)
Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A. , Rios, F. , Ceravolo, G., Graham, D. and Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis. Life Sciences, 179, pp. 110-119. (doi: 10.1016/j.lfs.2017.05.002) (PMID:28478264) (PMCID:5446265)
Touyz, R. M. , Montezano, A. C., Rios, F. , Widlansky, M. E. and Liang, M. (2017) Redox stress defines the small artery vasculopathy of hypertension: how do we bridge the bench-to-bedside gap? Circulation Research, 120(11), pp. 1721-1723. (doi: 10.1161/CIRCRESAHA.117.310672) (PMID:28546356) (PMCID:PMC5520661)
Friederich-Persson, M., Nguyen Dinh Cat, A., Persson, P., Montezano, A. C. and Touyz, R. M. (2017) Brown adipose tissue regulates small artery function through NADPH oxidase 4-derived hydrogen peroxide and redox-sensitive protein kinase G-1α. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(3), pp. 455-465. (doi: 10.1161/atvbaha.116.308659) (PMID:28062507)
Rios, F. J. , Touyz, R. M. and Montezano, A. C. (2017) Isolation and differentiation of human macrophages. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology, 1527. Springer: New York, pp. 311-320. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_24)
Montezano, A. C., Lopes, R. A.M. , Neves, K. B. , Rios, F. and Touyz, R. M. (2017) Isolation and culture of vascular smooth muscle cells from small and large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 349-354. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_27)
Montezano, A. C., Neves, K. B. , Lopes, R. A.M. and Rios, F. (2017) Isolation and culture of endothelial cells from large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 345-348. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_26)
Rios, F. J. , Touyz, R. M. and Montezano, A. C. (2017) Isolation and differentiation of murine macrophages. In: Touyz, R. M. and Shiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology. Humana Press, pp. 297-309. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_23)
2016
Callera, G. E., Antunes, T. T., He, Y., Montezano, A. C., Yogi, A., Savoia, C. and Touyz, R. M. (2016) c-Src inhibition improves cardiovascular function but not remodeling or fibrosis in Ang II-induced hypertension. Hypertension, 68(5), pp. 1179-1190. (doi: 10.1161/HYPERTENSIONAHA.116.07699) (PMID:27620391)
Callera, G. et al. (2016) Differential renal effects of candesartan at high-and ultra-high doses in diabetic mice: potential role of ACE2/AT2R/Mas. Bioscience Reports, 36(5), e00398. (doi: 10.1042/BSR20160344) (PMID:27612496) (PMCID:PMC5091470)
Alves-Lopes, R. , Neves, K. B. , Montezano, A., Harvey, A., Carneiro, F. S., Touyz, R. and Tostes, R. C. (2016) Internal pudendal artery dysfunction in diabetes is mediated by Nox1-derived Ros, NRF2- and RHO kinase-depedent mechanisms. Hypertension, 68(4), pp. 1056-1064. (doi: 10.1161/HYPERTENSIONAHA.116.07518) (PMID:27528061)
Touyz, R. , Anagnostopoulou, A., De Lucca Camargo, L. and Montezano, A. (2016) Novel biosensors reveal a shift in the redox paradigm from oxidative to reductive stress in heart disease. Circulation Research, 119(9), pp. 969-971. (doi: 10.1161/circresaha.116.309854) (PMID:27737937)
Bruder-Nascimento, T. et al. (2016) Renoprotective effects of atorvastatin in diabetic mice: downregulation of RhoA and upregulation of Akt/GSK3. PLoS ONE, 11(9), e0162731. (doi: 10.1371/journal.pone.0162731) (PMID:27649495) (PMCID:PMC5029810)
Hood, K. Y., Montezano, A. C., Harvey, A. P., Nilsen, M., MacLean, M. R. and Touyz, R. M. (2016) Nicotinamide adenine dinucleotide phosphate oxidase–mediated redox signaling and vascular remodeling by 16α-hydroxyestrone in human pulmonary artery cells. Hypertension, 68(3), pp. 796-808. (doi: 10.1161/HYPERTENSIONAHA.116.07668) (PMID:27402919) (PMCID:PMC4978604)
Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S. , MacLean, M. R., Montezano, A. and Touyz, R. M. (2016) Ang(1-7) influences ET-1 signaling through Mas: ETBR interactions: implications in pulmonary hypertension. Journal of Hypertension, 34(Supl 1), e216. (doi: 10.1097/01.hjh.0000500475.07008.db) (PMID:27754060)
Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S. , Montezano, A. C., MacLean, M. R. and Touyz, R. M. (2016) ANG-(1-7) and ET-1, a new partnership. Journal of Hypertension, 34, e382. (doi: 10.1097/01.hjh.0000500977.99529.fe) (PMID:27754197)
Tsiropoulou, S., Montezano, A., Scott, A., Burchmore, R.J. and Touyz, R.M. (2016) PS 07-14 vascular protein oxidation and redox proteomics in hypertension. Journal of Hypertension, 34, e287. (doi: 10.1097/01.hjh.0000500678.85921.bc)
Nguyen Dinh Cat, A. et al. (2016) Adipocyte-specific mineralocorticoid receptor overexpression in mice is associated with metabolic syndrome and vascular dysfunction: role of redox-sensitive PKG-1 and Rho kinase. Diabetes, 65(8), pp. 2392-2403. (doi: 10.2337/db15-1627) (PMID:27207514)
Harvey, A., Montezano, A. C., Lopes, R. A. , Rios, F. and Touyz, R. (2016) Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications. Canadian Journal of Cardiology, 32(5), pp. 659-668. (doi: 10.1016/j.cjca.2016.02.070) (PMID:27118293) (PMCID:PMC4906153)
Rios, F. J. , Lopes, R. A. , Neves, K. B., De Lucca Camargo, L. , Montezano, A. C. and Touyz, R. M. (2016) Off-target vascular effects of cholesteryl ester transfer protein inhibitors involve redox-sensitive and signal transducer and activator of transcription 3-dependent pathways. Journal of Pharmacology and Experimental Therapeutics, 357(2), pp. 415-422. (doi: 10.1124/jpet.115.230748) (PMID:26941168)
Rios, F. J. , Harvey, A., Lopes, R. A. , Montezano, A. C. and Touyz, R. (2016) Progenitor cells, bone marrow–derived fibrocytes and endothelial-to-mesenchymal transition: new players in vascular fibrosis. Hypertension, 67, pp. 272-274. (doi: 10.1161/HYPERTENSIONAHA.115.06220) (PMID:26693817)
Rios, F. J. , Montezano, A. C., Antunes, T. T. and Touyz, R. M. (2016) Magnesium, vascular function, and hypertension. In: Collins, J. F. (ed.) Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Academic Press, pp. 353-364. ISBN 9780128021682 (doi: 10.1016/B978-0-12-802168-2.00029-4)
Tsiropoulou, S., Dulak-Lis, M., Montezano, A. C. and Touyz, R. M. (2016) Biomarkers of oxidative stress in human hypertension. In: Andreadis, E. A. (ed.) Hypertension and Cardiovascular Disease. Springer, pp. 151-170. ISBN 9783319395975 (doi: 10.1007/978-3-319-39599-9_11)
2015
Kolisek, M., Montezano, A., Sponder, G., Anagnostopoulou, A., Vormann, J., Touyz, R. M. and Aschenbach, J. R. (2015) PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases. Clinical Science, 129(12), pp. 1143-1150. (doi: 10.1042/cs20150355) (PMID:26453619)
Lopes, R. , Neves, K. , Tostes, R., Montezano, A. and Touyz, R. (2015) Downregulation of nuclear factor erythroid 2–related factor and associated antioxidant genes contributes to redox-sensitive vascular dysfunction in hypertension. Hypertension, 2015(66), pp. 1240-1250. (doi: 10.1161/hypertensionaha.115.06163) (PMID:26503970)
Tsiropoulou, S., Montezano, A.C., Scott, A., Burchmore, R.J. and Touyz, R. (2015) 41 Vascular protein oxidation and redox proteomics in human hypertension. Heart, 101(Suppl), A13-A14. (doi: 10.1136/heartjnl-2015-308734.41)
Montezano, A. C., Tsiropoulou, S., Dulak-Lis, M., Harvey, A., De Lucca Camargo, L. and Touyz, R. M. (2015) Redox signaling, Nox5 and vascular remodeling in hypertension. Current Opinion in Nephrology and Hypertension, 24(5), pp. 425-433. (doi: 10.1097/MNH.0000000000000153) (PMID:26197203) (PMCID:PMC4727501)
Neves, K. B., Nguyen Dinh Cat, A., Lopes, R. A. M., Rios, F. J. , Anagnostopoulou, A., Lobato, N. S., de Oliveira, A. M., Tostes, R. C., Montezano, A. C. and Touyz, R. M. (2015) Chemerin regulates crosstalk between adipocytes and vascular cells through Nox. Hypertension, 66(3), pp. 657-666. (doi: 10.1161/HYPERTENSIONAHA.115.05616) (PMID:26150435)
Harvey, A., Montezano, A. C. and Touyz, R. M. (2015) Vascular biology of ageing—implications in hypertension. Journal of Molecular and Cellular Cardiology, 83, pp. 112-121. (doi: 10.1016/j.yjmcc.2015.04.011) (PMID:25896391) (PMCID:PMC4534766)
Montezano, A. C., Dulak-Lis, M., Tsiropoulou, S., Harvey, A., Briones, A. M. and Touyz, R. M. (2015) Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies. Canadian Journal of Cardiology, 31(5), pp. 631-641. (doi: 10.1016/j.cjca.2015.02.008) (PMID:25936489)
Rios, F. , Neves, K. B., Nguyen Dinh Cat, A., Even, S., Palacios, R. , Montezano, A. C. and Touyz, R. (2015) Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through nox-dependent processes. Journal of Pharmacology and Experimental Therapeutics, 353(1), pp. 27-34. (doi: 10.1124/jpet.114.221002) (PMID:25617244)
Veerabhadrappa, P. et al. (2015) Across the globe in 4 months: two international society of hypertension new investigator symposia in 2014. Journal of Hypertension, 33(4), pp. 891-893. (doi: 10.1097/HJH.0000000000000525) (PMID:25668359)
Touati, S., Montezano, A. C., Meziri, F., Riva, C., Touyz, R. M. and Laurant, P. (2015) Exercise training protects against atherosclerotic risk factors through vascular NADPH oxidase, extracellular signal-regulated kinase 1/2 and stress-activated protein kinase/c-Jun N-terminal kinase downregulation in obese rats. Clinical and Experimental Pharmacology and Physiology, 42(2), pp. 179-185. (doi: 10.1111/1440-1681.12338) (PMID:25399833)
Montezano, A. C., Nguyen Dinh Cat, A. and Touyz, R. M. (2015) Mas signaling: resolved and unresolved issues. In: Unger, T., Steckelings, U. M. and dos Santos, R. A.S. (eds.) The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications. Academic Press, pp. 169-179. ISBN 9780128013649 (doi: 10.1016/B978-0-12-801364-9.00023-7)
Welsh, P. , Preiss, D. , Tsiropoulou, S., Rios, F. J. , Harvey, A., Dulak-Lis, M. G., Montezano, A. C. and Touyz, R. M. (2015) Biomarkers of vascular inflammation and cardiovascular disease. In: Berbari, A. and Mancia, G. (eds.) Arterial Disorders: Definition, Clinical Manifestations, Mechanisms and Therapeutic Approaches. Springer: Cham, pp. 115-136. ISBN 9783319145556 (doi: 10.1007/978-3-319-14556-3_9)
2014
Touyz, R. M. , Montezano, A. C., Rios, F. J. and Savoia, C. (2014) Reply to letter by McIntyre et al. Canadian Journal of Cardiology, 30(12), 1733.e3. (doi: 10.1016/j.cjca.2014.10.004)
Jourd'heuil, D. et al. (2014) An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin ii-induced hypertension: in vivo and in vitro studies. PLoS ONE, 9(11), e111117. (doi: 10.1371/journal.pone.0111117) (PMID:25369284) (PMCID:PMC4219703)
Montezano, A. C. and Touyz, R. M. (2014) Mammalian target of Rapamycin: a novel pathway in vascular calcification. Canadian Journal of Cardiology, 30(5), pp. 482-484. (doi: 10.1016/j.cjca.2014.03.001)
Small, H. Y., Montezano, A. C., Rios, F. J. , Savoia, C. and Touyz, R. M. (2014) Hypertension due to antiangiogenic cancer therapy with vascular endothelial growth factor inhibitors: understanding and managing a new syndrome. Canadian Journal of Cardiology, 30(5), pp. 534-543. (doi: 10.1016/j.cjca.2014.02.011)
Holterman, C. E., Thibodeau, J.-F., Towaij, C., Gutsol, A., Montezano, A. C., Parks, R. J., Cooper, M. E., Touyz, R. M. and Kennedy, C. R.J. (2014) Nephropathy and elevated BP in mice with podocyte-specific NADPH oxidase 5 expression. Journal of the American Society of Nephrology, 25(4), pp. 784-797. (doi: 10.1681/ASN.2013040371)
Montezano, A. C., Nguyen Dinh Cat, A., Rios, F. J. and Touyz, R. M. (2014) Angiotensin II and vascular injury. Current Hypertension Reports, 16(6), p. 431. (doi: 10.1007/s11906-014-0431-2)
Montezano, A. C. and Touyz, R. M. (2014) Reactive oxygen species, vascular noxs, and hypertension: focus on translational and clinical research. Antioxidants and Redox Signaling, 20(1), pp. 164-182. (doi: 10.1089/ars.2013.5302)
Bruder‑Nascimento, T., Callera, G. E., Montezano, A. C., He, Y., Antunes, T. T., Nguyen Dinh Cat, A., Tostes, R. C. and Touyz, R. M. (2014) Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive nox-dependent pathways. Clinical Science, 128(7), pp. 411-423. (doi: 10.1042/CS20140456)
Montezano, A. C. and Touyz, R. M. (2014) Reactive oxygen species, vascular disease, and hypertension. In: Laher, I. (ed.) Systems Biology of Free Radicals and Antioxidants. Springer: Berlin, Heidelberg, pp. 1123-1154. ISBN 9783642300172 (doi: 10.1007/978-3-642-30018-9_56)
2013
Yogi, A. et al. (2013) Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain. Cellular Signalling, 25(11), pp. 2163-2175. (doi: 10.1016/j.cellsig.2013.07.002)
Nguyen Dinh Cat, A., Montezano, A.C., Burger, D. and Touyz, R.M. (2013) Angiotensin II, NADPH oxidase, and redox signaling in the vasculature. Antioxidants and Redox Signaling, 19(10), pp. 1110-1120. (doi: 10.1089/ars.2012.4641)
Bruder-Nascimento, T., Callera, G. E., Montezano, A. C., He, Y., Antunes, T., de Cassia Tostes, R., Touyz, R. M. and , (2013) Atorvastatin Inhibits Src/ROS-mediated Redox Sensitive And Pro-Inflammatory Actions of Aldosterone in Vascular Smooth Muscle Cells: Focus on Statins Pleiotropic Effects. Hypertension, 62(3 Sup), A488.
Bruder-Nascimento, T., Callera, G. E., Montezano, A. C., He, Y., Nguyen Dinh Cat, A., de Cassia Tostes, R. and Touyz, R. M. (2013) Atorvastatin downregulates vascular nox expression and ameliorates oxidative stress-associated inflammatory process in type 2 diabetic Db/db mice. Hypertension, 62(3 Sup), A33.
Callera, G. E., Montezano, A. C., Bruder-Nascimento, T. and Touyz, R. M. (2013) Downregulation of C-terminal Src kinase (csk) and Csk-binding protein (cbp) is associated with increased aldosterone-induced C-src phosphorylation in Shr vascular smooth muscle cells. Hypertension, 62(3 Sup), A350.
Even, S. et al. (2013) The Nox4 inhibitor GKT137831, prevents aldosterone production by adipocytes and protects against adipose tissue inflammation and fibrosis in obese mice. Hypertension, 62(3 Sup), A74.
Hood, K. Y., Montezano, A. C., MacLean, M. R. and Touyz, R. M. (2013) Differential effects of 17ß-estradiol and 16a-hydroxyestrone in oxidative stress and proliferative responses in human pulmonary artery smooth muscle cells - implications in pulmonary arterial hypertension. Hypertension, 62(3 Sup), A263.
Hood, K. Y., Montezano, A. C., Morecroft, I., MacLean, M. R. and Touyz, R. M. (2013) Serotonin signaling through Nox1 in human pulmonary artery smooth muscle cells - implications in vascular remodeling in pulmonary arterial hypertension. Hypertension, 62(3 Sup), A264.
Montezano, A. C. et al. (2013) Nox4 inhibition, by GKT 137831, decreases obesity-associated vascular dysfunction and pro-fibrotic effects. Hypertension, 62(3 Sup), A491.
Montezano, A. C., Yusuf, H., Graham, D. and Touyz, R. M. (2013) Redox-sensitive osteogenic factors as novel mediators of vascular injury in hypertension. Hypertension, 62(3 Sup), A490.
Nguyen Dinh Cat, A., Callera, G. E., Antunes, T. T., He, Y., Montezano, A. C., Bruder-Nascimento, T. and Touyz, R. M. (2013) Mineralocorticoid Receptor and Rhoa/rho Kinase Contribute to Vascular Dysfunction in Obese Db/db Mice. Hypertension, 62(3 Sup), A373.
Nguyen Dinh Cat, A., Callera, G. E., Antunes, T. T., Montezano, A. C., He, Y., Jenkins, C., Carter, A., Jaisser, F. and Touyz, R. M. (2013) Altered vascular reactivity in mice overexpressing adipocyte mineralocorticoid receptors - role of oxidative stress and Rho kinase. Hypertension, 62(3 Sup), A66.
Nguyen Dinh Cat, A., Callera, G. E., Antunes, T. T., Montezano, A. C., Jenkins, C., Touyz, R. M. and He, Y. (2013) Upregulation of the mineralocorticoid system in obesity-associated diabetes leads to increased adipocyte Rho kinase activation and dysregulation of adipocytokines. Hypertension, 62(3 Sup), A372.
Rios, F. J. , Nguyen Dinh Cat, A., Palacios, R. , Carswell, A., Montezano, A. C. and Touyz, R. M. (2013) Torcetrapib and dalcetrapib, CETP inhibitors, induce adipocyte-derived aldosterone and reactive oxygen species formation. Hypertension, 62(3 Sup), A356.
Gray, S.P. et al. (2013) NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. Circulation, 127(18), pp. 1888-1902. (doi: 10.1161/CIRCULATIONAHA.112.132159)
Burger, D., Schock, S., Thompson, C.S., Montezano, A.C., Hakim, A.M. and Touyz, R.M. (2013) Microparticles: biomarkers and beyond. Clinical Science, 124(7), pp. 423-441. (doi: 10.1042/CS20120309)
Montezano, A.C. and Touyz, R.M. (2013) Mechanosensitive regulation of cortactin by p47phox: a new paradigm in cytoskeletal remodeling. Circulation Research, 112(12), pp. 1522-1525. (doi: 10.1161/CIRCRESAHA.113.301495)
Sedeek, M. et al. (2013) Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes. Clinical Science, 124(3), pp. 191-202. (doi: 10.1042/CS20120330)
2012
Sedeek, M. et al. (2012) Oxidative stress, Nox isoforms and complications of diabetes—potential targets for novel therapies. Journal of Cardiovascular Translational Research, 5(4), pp. 509-518. (doi: 10.1007/s12265-012-9387-2)
Burger, D., Kwart, D. G., Montezano, A. C., Read, N. C., Kennedy, C. R.J., Thompson, C. S. and Touyz, R. M. (2012) Microparticles induce cell cycle arrest through redox-sensitive processes in endothelial cells: implications in vascular senescence. Journal of the American Heart Association, 1(3), e001842. (doi: 10.1161/JAHA.112.001842)
Chignalia, A. Z. et al. (2012) Testosterone induces vascular smooth muscle cell migration by NADPH oxidase and c-Src-dependent pathways. Hypertension, 59(6), pp. 1263-1271. (doi: 10.1161/HYPERTENSIONAHA.111.180620) (PMID:22566500)
Montezano, A.C. and Touyz, R.M. (2012) Oxidative stress, Noxs, and hypertension: experimental evidence and clinical controversies. Annals of Medicine, 44(S1), S2-S16. (doi: 10.3109/07853890.2011.653393)
Montezano, A.C. and Touyz, R.M. (2012) Molecular mechanisms of hypertension—reactive oxygen species and antioxidants: a basic science update for the clinician. Canadian Journal of Cardiology, 28(3), pp. 288-295. (doi: 10.1016/j.cjca.2012.01.017)
Montezano, A.C. (2012) Molecular mechanisms of hypertension—reactive oxygen species and antioxidants: a basic science update for the clinici. Canadian Journal of Cardiology, 28(3), pp. 288-295. (doi: 10.1016/j.cjca.2012.01.017)
Montezano, A.C. and Touyz, R.M. (2012) Reactive oxygen species and endothelial function - role of nitric oxide synthase uncoupling and nox family Nicotinamide Adenine Dinucleotide Phosphate oxidases. Basic and Clinical Pharmacology and Toxicology, 110(1), pp. 87-94. (doi: 10.1111/j.1742-7843.2011.00785.x)
Montezano, A.C. and Touyz, R.M. (2012) Reactive Oxygen Species and the Cardiovascular System. Series: Integrated systems physiology. Morgan & Claypool. ISBN 9781615043620
Paravicini, T.M., Montezano, A.C., Yusuf, H. and Touyz, R.M. (2012) Activation of vascular p38MAPK by mechanical stretch is independent of c-Src and NADPH oxidase: influence of hypertension and angiotensin II. Journal of the American Society of Hypertension, 6(3), pp. 169-178. (doi: 10.1016/j.jash.2012.01.002)
Touyz, R.M. and Montezano, A.C. (2012) Vascular Nox4: a multifarious NADPH oxidase. Circulation Research, 110(9), pp. 1159-1161. (doi: 10.1161/CIRCRESAHA.112.269068)
White, M., Montezano, A.C. and Touyz, R.M. (2012) Angiotensin II signalling and calcineurin in cardiac fibroblasts: differential effects of calcineurin inhibitors FK506 and cyclosporine A. Therapeutic Advances in Cardiovascular Disease, 6(1), pp. 5-14. (doi: 10.1177/1753944711432901)
2011
Cascino, T., Csanyi, G., Al Ghouleh, I., Montezano, A.C., Touyz, R.M. , Haurani, M.J. and Pagano, P.J. (2011) Adventitia-derived hydrogen peroxide impairs relaxation of the rat carotid artery via smooth muscle cell p38 mitogen-activated protein kinase. Antioxidants and Redox Signaling, 15(6), pp. 1507-1515. (doi: 10.1089/ars.2010.3631)
Callera, G.E., Yogi, A., Briones, A.M., Montezano, A.C., He, Y., Tostes, R.C.A., Schiffrin, E.L. and Touyz, R.M. (2011) Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: role of PDGFR. Cardiovascular Research, 91(4), pp. 720-731. (doi: 10.1093/cvr/cvr131) (PMID:21576132)
Touyz, R.M. , Briones, A.M., Sedeek, M., Burger, D. and Montezano, A.C. (2011) NOX isoforms and reactive oxygen species in vascular health. Molecular Interventions, 11(1), pp. 27-35. (doi: 10.1124/mi.11.1.5)
Briones, A.M., Tabet, F., Callera, G.E., Montezano, A.C., Yogi, A., He, Y., Quinn, M.T., Salaices, M. and Touyz, R.M. (2011) Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR. Journal of the American Society of Hypertension, 5(3), pp. 137-153. (doi: 10.1016/j.jash.2011.02.001)
Nguyen Dinh Cat, A., Briones, A.M., Callera, G.E., Yogi, A., He, Y., Montezano, A.C. and Touyz, R.M. (2011) Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors. Hypertension, 58(3), pp. 479-488. (doi: 10.1161/HYPERTENSIONAHA.110.168872)
Savoia, C.,, Burger, D., Nishigaki, N., Montezano, A. and Touyz, R.M. (2011) Angiotensin II and the vascular phenotype in hypertension. Expert Reviews in Molecular Medicine, 13(e11), pp. 1-25. (doi: 10.1017/S1462399411001815)
2010
Montezano, A.C. et al. (2010) Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells. Circulation Research, 106(8), pp. 1363-1373. (doi: 10.1161/CIRCRESAHA.109.216036)
Montezano, A.C., Burger, D., Ceravolo, G.S., Yusuf, H., Montero, M. and Touyz, R.M. (2010) Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5. Clinical Science, 120(4), pp. 131-141. (doi: 10.1042/CS20100384)
Montezano, A.C., Zimmerman, D., Yusuf, H., Burger, D., Chignalia, A.Z., Wadhera, V., van Leeuwen, F.N. and Touyz, R.M. (2010) Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium. Hypertension, 56(3), pp. 453-462. (doi: 10.1161/HYPERTENSIONAHA.110.152058)
2009
Touyz, R.M. and Montezano, A.C. (2009) Vascular smooth muscle cells sense calcium: a new paradigm in vascular calcification. Cardiovascular Research, 81(2), pp. 237-239. (doi: 10.1093/cvr/cvn345) (PMID:19088081)
Callera, G.E., He, Y., Yogi, A., Montezano, A.C., Paravicini, T., Yao, G. and Touyz, R.M. (2009) Regulation of the novel Mg2+ transporter transient receptor potential melastatin 7 (TRPM7) cation channel by bradykinin in vascular smooth muscle cells. Journal of Hypertension, 27(1), pp. 155-166. (doi: 10.1097/HJH.0b013e3283190582)
2008
Montezano, A.C., Callera, G.E., Yogi, A., He, Y., Tostes, R.C., He, G., Schiffrin, E.L. and Touyz, R.M. (2008) Aldosterone and Angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(8), pp. 1511-1518. (doi: 10.1161/ATVBAHA.108.168021)
Montezano, A.C. and Touyz, R.M. (2008) Networking between systemic Angiotensin II and cardiac mineralocorticoid receptors. Hypertension, 52(6), pp. 1016-1018. (doi: 10.1161/HYPERTENSIONAHA.108.121269)
Sontia, B., Montezano, A.C., Paravicini, T., Tabet, F. and Touyz, R.M. (2008) Downregulation of renal TRPM7 and increased inflammation and fibrosis in aldosterone-infused mice: effects of magnesium. Hypertension, 51(4), pp. 915-921. (doi: 10.1161/HYPERTENSIONAHA.107.100339)
Yogi, A., Mercure, C., Touyz, J., Callera, G.E., Montezano, A.C., Aranha, A.B., Tostes, R.C., Reudelhuber, T. and Touyz, R.M. (2008) Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in Angiotensin II-dependent chronic hypertension. Hypertension, 51(2), pp. 500-506. (doi: 10.1161/HYPERTENSIONAHA.107.103192)
2007
Montezano, A.C., Amiri, F., Tostes, R.C., Touyz, R.M. and Schiffrin, E.L. (2007) Inhibitory effects of PPAR-γ on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats. Journal of the American Society of Hypertension, 1(2), pp. 150-160. (doi: 10.1016/j.jash.2007.01.005)
Touyz, R.M. , Savoia, C., He, Y., Endemann, D., Pu, Q., Ko, E.A., DeCiuceis, C., Montezano, A.C. and Schiffrin, E.L. (2007) Increased inflammatory biomarkers in hypertensive type 2 diabetic patients: improvement after angiotensin II type 1 receptor blockade. Journal of the American Society of Hypertension, 1(3), pp. 189-199. (doi: 10.1016/j.jash.2007.01.009)
Yogi, A., Callera, G.E., Montezano, A.C., Aranha, A.B., Tostes, R.C., Schiffrin, E.L. and Touyz, R.M. (2007) Endothelin-1, but not Ang II, activates MAP kinases through c-Src-independent Ras-Raf-dependent pathways in vascular smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(9), pp. 1960-1967. (doi: 10.1161/ATVBAHA.107.146746)
2006
Callera, G.E., Tostes, R.C., Yogi, A., Montezano, A.C. and Touyz, R.M. (2006) Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms. Clinical Science, 110(2), pp. 243-253. (doi: 10.1042/CS20050307)
Touyz, R.M. , He, Y., Montezano, A.C., Yao, G., Chubanov, V., Gudermann, T. and Callera, G.E. (2006) Differential regulation of transient receptor potential melastatin 6 and 7 cation channels by ANG II in vascular smooth muscle cells from spontaneously hypertensive rats. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 290(1), R73-R78. (doi: 10.1152/ajpregu.00515.2005)
2005
Callera, G. E., Montezano, A.C., Alvaro, Y., Tostes, R.C., He, Y., Schriffin, E. and Touyz, R.M. (2005) c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats. Hypertension, 46(4), pp. 1032-1038. (doi: 10.1161/01.HYP.0000176588.51027.35)
2004
Callera, G.E., Montezano, A.C., Touyz, R.M. , Zorn, T.M.T., Carvalho, M.H., Fortes, Z.B., Nigro, D., Schriffin, E.L. and Tostes, R.C. (2004) ETA receptor mediates altered leukocyte-endothelial cell interaction and adhesion molecules expression in DOCA-salt rats. Hypertension, 43(4), pp. 872-879. (doi: 10.1161/01.HYP.0000117296.30296.14)
Articles
Tobias, E. S. et al. (2024) SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis. Endocrine, (doi: 10.1007/s12020-024-03701-x) (PMID:38400880) (Early Online Publication)
Lucas-Herald, A. K. et al. (2023) Effects of sex hormones on vascular reactivity in boys with hypospadias. Journal of Clinical Endocrinology and Metabolism, (doi: 10.1210/clinem/dgad525) (PMID:37672642) (Early Online Publication)
Montezano, A. C. et al. (2023) SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication. Scientific Reports, 13, 14086. (doi: 10.1038/s41598-023-41115-3) (PMID:37640791) (PMCID:PMC10462711)
Morris, H. E., Neves, K. B. , Nilsen, M., Montezano, A. C., MacLean, M. R. and Touyz, R. M. (2023) Notch3/Hes5 induces vascular dysfunction in hypoxia-induced pulmonary hypertension through ER stress and redox-sensitive pathways. Hypertension, 80(8), pp. 1683-1696. (doi: 10.1161/hypertensionaha.122.20449) (PMID:37254738)
Sykes, R. A. et al. (2023) Vascular mechanisms of post-COVID-19 conditions: rho-kinase is a novel target for therapy. European Heart Journal: Cardiovascular Pharmacotherapy, 9(4), pp. 371-386. (doi: 10.1093/ehjcvp/pvad025) (PMID:37019821) (PMCID:PMC10236521)
Neves, K. B. , Alves‐Lopes, R. , Montezano, A. C. and Touyz, R. M. (2023) Role of PARP and TRPM2 in VEGF inhibitor‐induced vascular dysfunction. Journal of the American Heart Association, 12(4), e027769. (doi: 10.1161/JAHA.122.027769) (PMID:36802924) (PMCID:PMC10111475)
Rios, F. J. et al. (2022) TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt. Communications Biology, 5, 746. (doi: 10.1038/s42003-022-03715-z) (PMID:35882956) (PMCID:PMC9325869)
Lucas-Herald, A. K. et al. (2022) Vascular dysfunction and increased cardiovascular risk in hypospadias. European Heart Journal, 43(19), pp. 1832-1845. (doi: 10.1093/eurheartj/ehac112) (PMID:35567552) (PMCID:PMC9113289)
Mirabito Colafella, K. M. et al. (2022) Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage. Clinical Science, 136(9), pp. 675-694. (doi: 10.1042/CS20220182) (PMID:35441670) (PMCID:PMC9093150)
Camargo, L. L. et al. (2022) Central role of c-Src in NOX5- mediated redox signaling in vascular smooth muscle cells in human hypertension. Cardiovascular Research, 118(5), pp. 1359-1373. (doi: 10.1093/cvr/cvab171) (PMID:34320175) (PMCID:PMC8953456)
Neves, K. B. , Rios, F. J. , Sevilla-Montero, J., Montezano, A. C. and Touyz, R. M. (2022) Exosomes and the cardiovascular system: role in cardiovascular health and disease. Journal of Physiology, (doi: 10.1113/JP282054) (PMID:35306667) (Early Online Publication)
Connelly, P. J. , Casey, H., Montezano, A. C., Touyz, R. M. and Delles, C. (2022) Sex steroids receptors, hypertension and vascular ageing. Journal of Human Hypertension, 36(2), pp. 120-125. (doi: 10.1038/s41371-021-00576-7) (PMID:34230581) (PMCID:PMC8850193)
Mahindra, A. et al. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16(11), e0260283. (doi: 10.1371/journal.pone.0260283) (PMID:34793553) (PMCID:PMC8601423)
Touyz, R. M. et al. (2021) Cardiovascular and renal risk factors and complications associated with COVID-19. CJC Open, 3(10), pp. 1257-1272. (doi: 10.1016/j.cjco.2021.05.020) (PMID:34151246) (PMCID:PMC8205551)
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Griendling, K. K., Camargo, L. L., Rios, F. , Alves-Lopes, R., Montezano, A. C. and Touyz, R. M. (2021) Oxidative stress and hypertension. Circulation Research, 128(7), pp. 993-1020. (doi: 10.1161/CIRCRESAHA.121.318063) (PMID:33793335)
Neves, K. B. , Morris, H., Alves-Lopes, R., Muir, K. W. , Moreton, F., Delles, C. , Montezano, A. C. and Touyz, R. M. (2021) Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO∕sGC∕cGMP pathway. Clinical Science, 135(6), pp. 753-773. (doi: 10.1042/CS20201412) (PMID:33681964)
Kuriakose, J., Montezano, A. C. and Touyz, R. M. (2021) ACE-2/Ang (1-7)/Mas axis and the vascular system: vasoprotection to COVID-19-associated vascular disease. Clinical Science, 135(2), pp. 387-407. (doi: 10.1042/CS20200480) (PMID:33511992) (PMCID:PMC7846970)
Anagnostopoulou, A., Camargo, L. L. , Rodrigues, D., Montezano, A. C. and Touyz, R. M. (2020) Importance of cholesterol-rich microdomains in the regulation of Nox isoforms and redox signaling in human vascular smooth muscle cells. Scientific Reports, 10, 17818. (doi: 10.1038/s41598-020-73751-4) (PMID:33082354) (PMCID:PMC7575553)
Cameron, A. C. et al. (2020) Comprehensive characterisation of the vascular effects of cisplatin-based chemotherapy in patients with testicular cancer. JACC: CardioOncology, 2(3), pp. 443-455. (doi: 10.1016/j.jaccao.2020.06.004) (PMID:33043304) (PMCID:PMC7539369)
Zhao, G.-J. et al. (2020) Ca2+-dependent NOX5 (NADPH oxidase 5) exaggerates cardiac hypertrophy through reactive oxygen species production. Hypertension, 76(3), pp. 827-838. (doi: 10.1161/HYPERTENSIONAHA.120.15558)
Rossitto, G. et al. (2020) Tissue sodium excess is not hypertonic and reflects extracellular volume expansion. Nature Communications, 11, 4222. (doi: 10.1038/s41467-020-17820-2) (PMID:32839436) (PMCID:PMC7445299)
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Touyz, R. , Rios, F. , Alves-Lopes, R., Neves, K. B. , De Lucca Camargo, L. and Montezano, A. C. (2020) Oxidative stress: a unifying paradigm in hypertension. Canadian Journal of Cardiology, 36, pp. 659-670. (doi: 10.1016/j.cjca.2020.02.081) (PMID:32389339) (PMCID:PMC7225748)
Bautista-Niño, P. K. et al. (2020) Local endothelial DNA repair defect causes aging-resembling endothelial-specific dysfunction. Clinical Science, 134(7), pp. 727-746. (doi: 10.1042/cs20190124) (PMID:32202295)
Rios, F. J. , Montezano, A. C. and Touyz, R. M. (2020) Lessons learned from RAG-1-deficient mice in hypertension. Hypertension, 75(4), pp. 935-937. (doi: 10.1161/hypertensionaha.119.14406) (PMID:32078397)
Rios, F. J. et al. (2020) Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis. Cardiovascular Research, 116(3), pp. 721-735. (doi: 10.1093/cvr/cvz164) (PMID:31250885) (PMCID:PMC7252442)
Alves-Lopes, R., Neves, K. B. , Anagnostopoulou, A., Rios, F. J. , Lacchini, S., Montezano, A. C. and Touyz, R. M. (2020) Crosstalk between vascular redox and calcium signaling in hypertension involves TRPM2 (Transient Receptor Potential Melastatin 2) cation channel. Hypertension, 75(1), pp. 139-149. (doi: 10.1161/hypertensionaha.119.13861) (PMID:31735084)
Morris, H., Neves, K. B. , Montezano, A. C., Maclean, M. R. and Touyz, R. (2019) Notch3 signaling and vascular remodeling in pulmonary arterial hypertension. Clinical Science, 133(24), pp. 2481-2498. (doi: 10.1042/CS20190835) (PMID:31868216) (PMCID:PMC6928565)
Neves, K. B. et al. (2019) ER stress and Rho kinase activation underlie the vasculopathy of CADASIL. JCI Insight, 4(23), e131344. (doi: 10.1172/jci.insight.131344) (PMID:31647781) (PMCID:PMC6962020)
Touyz, R. M. , Anagnostopoulou, A., Rios, F. , Montezano, A. C. and De Lucca Camargo, L. (2019) NOX5: molecular biology and pathophysiology. Experimental Physiology, 104(5), pp. 605-616. (doi: 10.1113/EP086204) (PMID:30801870) (PMCID:PMC6519284)
Neves, K. B. , Rios, F. J. , Jones, R. , Evans, T. R. J. , Montezano, A. C. and Touyz, R. M. (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115(5), pp. 978-988. (doi: 10.1093/cvr/cvz021) (PMID:30753341) (PMCID:PMC6452312)
Zou, Z.-G., Rios, F. J. , Montezano, A. C. and Touyz, R. M. (2019) TRPM7, magnesium and signaling. International Journal of Molecular Sciences, 20(8), 1877. (doi: 10.3390/ijms20081877) (PMID:30995736) (PMCID:PMC6515203)
Bruder-Nascimento, T., Callera, G. E., Montezano, A. C., Belin de Chantemele, E. J., Tostes, R. C. and Touyz, R. M. (2019) Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress. Life Sciences, 221, pp. 29-34. (doi: 10.1016/j.lfs.2019.01.043) (PMID:30721707) (PMCID:PMC6686670)
Touyz, R. M. , Anagnostopoulou, A., De Lucca Camargo, L. , Rios, F. J. and Montezano, A. C. (2019) Vascular biology of superoxide-generating NADPH oxidase 5 (Nox5)- implications in hypertension and cardiovascular disease. Antioxidants and Redox Signaling, 30(7), pp. 1027-1040. (doi: 10.1089/ars.2018.7583) (PMID:30334629) (PMCID:PMC6354601)
Ford, T. J. et al. (2018) Systemic microvascular dysfunction in microvascular and vasospastic angina. European Heart Journal, 39(46), pp. 4086-4097. (doi: 10.1093/eurheartj/ehy529) (PMID:30165438) (PMCID:PMC6284165)
Neves, K. B. , Nguyen Dinh Cat, A., Alves-Lopes, R. , Harvey, K. Y., da Costa, R. M., Lobato, N. S., Montezano, A. C., Oliveira, A. M., Touyz, R. M. and Tostes, R. C. (2018) Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways. American Journal of Physiology: Heart and Circulatory Physiology, 315(6), H1851-H1860. (doi: 10.1152/ajpheart.00285.2018) (PMID:30216119) (PMCID:PMC6336978)
Neves, K. B. , Montezano, A. C., Alves-Lopes, R. , Bruder-Nascimento, T., Costa, R. M., Costa, R. S., Touyz, R. M. and Tostes, R. C. (2018) Upregulation of Nrf2 and decreased redox signaling contribute to renoprotective effects of chemerin receptor blockade in diabetic mice. International Journal of Molecular Sciences, 19(8), 2454. (doi: 10.3390/ijms19082454) (PMID:30126255) (PMCID:PMC6121242)
De Lucca Camargo, L. et al. (2018) Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72(1), pp. 235-246. (doi: 10.1161/HYPERTENSIONAHA.118.10824) (PMID:29844144) (PMCID:PMC6004120)
Montezano, A. C. et al. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), e009388. (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)
Neves, K. B. , Rios, F. J. , Van Der Mey, L., Alves-Lopes, R. , Cameron, A. C., Volpe, M., Montezano, A. C., Savoia, C. and Touyz, R. M. (2018) VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71(4), pp. 638-647. (doi: 10.1161/HYPERTENSIONAHA.117.10490) (PMID:29483228)
Touyz, R. M. , Alves-Lopes, R. , Rios, F. J. , De Lucca Camargo, L. , Anagnostopoulou, A., Arner, A. and Montezano, A. C. (2018) Vascular smooth muscle contraction in hypertension. Cardiovascular Research, 114(4), pp. 529-539. (doi: 10.1093/cvr/cvy023) (PMID:29394331) (PMCID:PMC5852517)
Nguyen Dinh Cat, A. et al. (2018) Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling. Scientific Reports, 8, 2952. (doi: 10.1038/s41598-018-21087-5) (PMID:29440699) (PMCID:PMC5811612)
Touyz, R. M. and Montezano, A. C. (2018) Angiotensin-(1–7) and vascular function: the clinical context. Hypertension, 71(1), pp. 68-69. (doi: 10.1161/HYPERTENSIONAHA.117.10406) (PMID:29203630)
Silva, S. D., Jara, Z. P., Peres, R., Lima, L. S., Scavone, C., Montezano, A. C., Touyz, R. M. , Casarini, D. E. and Michelini, L. C. (2017) Temporal changes in cardiac oxidative stress, inflammation and remodeling induced by exercise in hypertension: Role for local angiotensin II reduction. PLoS ONE, 12(12), e0189535. (doi: 10.1371/journal.pone.0189535) (PMID:29232407) (PMCID:PMC5726656)
Skiba, D.S. et al. (2017) Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis. British Journal of Pharmacology, 174(22), pp. 4055-4069. (doi: 10.1111/bph.13685) (PMID:27935022) (PMCID:PMC5659999)
Hood, K. Y., Mair, K. M., Harvey, A. P., Montezano, A. C., Touyz, R. M. and MacLean, M. R. (2017) Serotonin signaling through the 5-HT1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(7), pp. 1361-1370. (doi: 10.1161/ATVBAHA.116.308929) (PMID:28473438) (PMCID:PMC5478178)
Lucas-Herald, A. K. , Alves-Lopes, R. , Montezano, A. C., Ahmed, S. F. and Touyz, R. M. (2017) Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications. Clinical Science, 131(13), pp. 1405-1418. (doi: 10.1042/CS20170090) (PMID:28645930) (PMCID:PMC5736922)
Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A. , Rios, F. , Ceravolo, G., Graham, D. and Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis. Life Sciences, 179, pp. 110-119. (doi: 10.1016/j.lfs.2017.05.002) (PMID:28478264) (PMCID:5446265)
Touyz, R. M. , Montezano, A. C., Rios, F. , Widlansky, M. E. and Liang, M. (2017) Redox stress defines the small artery vasculopathy of hypertension: how do we bridge the bench-to-bedside gap? Circulation Research, 120(11), pp. 1721-1723. (doi: 10.1161/CIRCRESAHA.117.310672) (PMID:28546356) (PMCID:PMC5520661)
Friederich-Persson, M., Nguyen Dinh Cat, A., Persson, P., Montezano, A. C. and Touyz, R. M. (2017) Brown adipose tissue regulates small artery function through NADPH oxidase 4-derived hydrogen peroxide and redox-sensitive protein kinase G-1α. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(3), pp. 455-465. (doi: 10.1161/atvbaha.116.308659) (PMID:28062507)
Callera, G. E., Antunes, T. T., He, Y., Montezano, A. C., Yogi, A., Savoia, C. and Touyz, R. M. (2016) c-Src inhibition improves cardiovascular function but not remodeling or fibrosis in Ang II-induced hypertension. Hypertension, 68(5), pp. 1179-1190. (doi: 10.1161/HYPERTENSIONAHA.116.07699) (PMID:27620391)
Callera, G. et al. (2016) Differential renal effects of candesartan at high-and ultra-high doses in diabetic mice: potential role of ACE2/AT2R/Mas. Bioscience Reports, 36(5), e00398. (doi: 10.1042/BSR20160344) (PMID:27612496) (PMCID:PMC5091470)
Alves-Lopes, R. , Neves, K. B. , Montezano, A., Harvey, A., Carneiro, F. S., Touyz, R. and Tostes, R. C. (2016) Internal pudendal artery dysfunction in diabetes is mediated by Nox1-derived Ros, NRF2- and RHO kinase-depedent mechanisms. Hypertension, 68(4), pp. 1056-1064. (doi: 10.1161/HYPERTENSIONAHA.116.07518) (PMID:27528061)
Touyz, R. , Anagnostopoulou, A., De Lucca Camargo, L. and Montezano, A. (2016) Novel biosensors reveal a shift in the redox paradigm from oxidative to reductive stress in heart disease. Circulation Research, 119(9), pp. 969-971. (doi: 10.1161/circresaha.116.309854) (PMID:27737937)
Bruder-Nascimento, T. et al. (2016) Renoprotective effects of atorvastatin in diabetic mice: downregulation of RhoA and upregulation of Akt/GSK3. PLoS ONE, 11(9), e0162731. (doi: 10.1371/journal.pone.0162731) (PMID:27649495) (PMCID:PMC5029810)
Hood, K. Y., Montezano, A. C., Harvey, A. P., Nilsen, M., MacLean, M. R. and Touyz, R. M. (2016) Nicotinamide adenine dinucleotide phosphate oxidase–mediated redox signaling and vascular remodeling by 16α-hydroxyestrone in human pulmonary artery cells. Hypertension, 68(3), pp. 796-808. (doi: 10.1161/HYPERTENSIONAHA.116.07668) (PMID:27402919) (PMCID:PMC4978604)
Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S. , MacLean, M. R., Montezano, A. and Touyz, R. M. (2016) Ang(1-7) influences ET-1 signaling through Mas: ETBR interactions: implications in pulmonary hypertension. Journal of Hypertension, 34(Supl 1), e216. (doi: 10.1097/01.hjh.0000500475.07008.db) (PMID:27754060)
Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S. , Montezano, A. C., MacLean, M. R. and Touyz, R. M. (2016) ANG-(1-7) and ET-1, a new partnership. Journal of Hypertension, 34, e382. (doi: 10.1097/01.hjh.0000500977.99529.fe) (PMID:27754197)
Tsiropoulou, S., Montezano, A., Scott, A., Burchmore, R.J. and Touyz, R.M. (2016) PS 07-14 vascular protein oxidation and redox proteomics in hypertension. Journal of Hypertension, 34, e287. (doi: 10.1097/01.hjh.0000500678.85921.bc)
Nguyen Dinh Cat, A. et al. (2016) Adipocyte-specific mineralocorticoid receptor overexpression in mice is associated with metabolic syndrome and vascular dysfunction: role of redox-sensitive PKG-1 and Rho kinase. Diabetes, 65(8), pp. 2392-2403. (doi: 10.2337/db15-1627) (PMID:27207514)
Harvey, A., Montezano, A. C., Lopes, R. A. , Rios, F. and Touyz, R. (2016) Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications. Canadian Journal of Cardiology, 32(5), pp. 659-668. (doi: 10.1016/j.cjca.2016.02.070) (PMID:27118293) (PMCID:PMC4906153)
Rios, F. J. , Lopes, R. A. , Neves, K. B., De Lucca Camargo, L. , Montezano, A. C. and Touyz, R. M. (2016) Off-target vascular effects of cholesteryl ester transfer protein inhibitors involve redox-sensitive and signal transducer and activator of transcription 3-dependent pathways. Journal of Pharmacology and Experimental Therapeutics, 357(2), pp. 415-422. (doi: 10.1124/jpet.115.230748) (PMID:26941168)
Rios, F. J. , Harvey, A., Lopes, R. A. , Montezano, A. C. and Touyz, R. (2016) Progenitor cells, bone marrow–derived fibrocytes and endothelial-to-mesenchymal transition: new players in vascular fibrosis. Hypertension, 67, pp. 272-274. (doi: 10.1161/HYPERTENSIONAHA.115.06220) (PMID:26693817)
Kolisek, M., Montezano, A., Sponder, G., Anagnostopoulou, A., Vormann, J., Touyz, R. M. and Aschenbach, J. R. (2015) PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases. Clinical Science, 129(12), pp. 1143-1150. (doi: 10.1042/cs20150355) (PMID:26453619)
Lopes, R. , Neves, K. , Tostes, R., Montezano, A. and Touyz, R. (2015) Downregulation of nuclear factor erythroid 2–related factor and associated antioxidant genes contributes to redox-sensitive vascular dysfunction in hypertension. Hypertension, 2015(66), pp. 1240-1250. (doi: 10.1161/hypertensionaha.115.06163) (PMID:26503970)
Tsiropoulou, S., Montezano, A.C., Scott, A., Burchmore, R.J. and Touyz, R. (2015) 41 Vascular protein oxidation and redox proteomics in human hypertension. Heart, 101(Suppl), A13-A14. (doi: 10.1136/heartjnl-2015-308734.41)
Montezano, A. C., Tsiropoulou, S., Dulak-Lis, M., Harvey, A., De Lucca Camargo, L. and Touyz, R. M. (2015) Redox signaling, Nox5 and vascular remodeling in hypertension. Current Opinion in Nephrology and Hypertension, 24(5), pp. 425-433. (doi: 10.1097/MNH.0000000000000153) (PMID:26197203) (PMCID:PMC4727501)
Neves, K. B., Nguyen Dinh Cat, A., Lopes, R. A. M., Rios, F. J. , Anagnostopoulou, A., Lobato, N. S., de Oliveira, A. M., Tostes, R. C., Montezano, A. C. and Touyz, R. M. (2015) Chemerin regulates crosstalk between adipocytes and vascular cells through Nox. Hypertension, 66(3), pp. 657-666. (doi: 10.1161/HYPERTENSIONAHA.115.05616) (PMID:26150435)
Harvey, A., Montezano, A. C. and Touyz, R. M. (2015) Vascular biology of ageing—implications in hypertension. Journal of Molecular and Cellular Cardiology, 83, pp. 112-121. (doi: 10.1016/j.yjmcc.2015.04.011) (PMID:25896391) (PMCID:PMC4534766)
Montezano, A. C., Dulak-Lis, M., Tsiropoulou, S., Harvey, A., Briones, A. M. and Touyz, R. M. (2015) Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies. Canadian Journal of Cardiology, 31(5), pp. 631-641. (doi: 10.1016/j.cjca.2015.02.008) (PMID:25936489)
Rios, F. , Neves, K. B., Nguyen Dinh Cat, A., Even, S., Palacios, R. , Montezano, A. C. and Touyz, R. (2015) Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through nox-dependent processes. Journal of Pharmacology and Experimental Therapeutics, 353(1), pp. 27-34. (doi: 10.1124/jpet.114.221002) (PMID:25617244)
Veerabhadrappa, P. et al. (2015) Across the globe in 4 months: two international society of hypertension new investigator symposia in 2014. Journal of Hypertension, 33(4), pp. 891-893. (doi: 10.1097/HJH.0000000000000525) (PMID:25668359)
Touati, S., Montezano, A. C., Meziri, F., Riva, C., Touyz, R. M. and Laurant, P. (2015) Exercise training protects against atherosclerotic risk factors through vascular NADPH oxidase, extracellular signal-regulated kinase 1/2 and stress-activated protein kinase/c-Jun N-terminal kinase downregulation in obese rats. Clinical and Experimental Pharmacology and Physiology, 42(2), pp. 179-185. (doi: 10.1111/1440-1681.12338) (PMID:25399833)
Touyz, R. M. , Montezano, A. C., Rios, F. J. and Savoia, C. (2014) Reply to letter by McIntyre et al. Canadian Journal of Cardiology, 30(12), 1733.e3. (doi: 10.1016/j.cjca.2014.10.004)
Jourd'heuil, D. et al. (2014) An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin ii-induced hypertension: in vivo and in vitro studies. PLoS ONE, 9(11), e111117. (doi: 10.1371/journal.pone.0111117) (PMID:25369284) (PMCID:PMC4219703)
Montezano, A. C. and Touyz, R. M. (2014) Mammalian target of Rapamycin: a novel pathway in vascular calcification. Canadian Journal of Cardiology, 30(5), pp. 482-484. (doi: 10.1016/j.cjca.2014.03.001)
Small, H. Y., Montezano, A. C., Rios, F. J. , Savoia, C. and Touyz, R. M. (2014) Hypertension due to antiangiogenic cancer therapy with vascular endothelial growth factor inhibitors: understanding and managing a new syndrome. Canadian Journal of Cardiology, 30(5), pp. 534-543. (doi: 10.1016/j.cjca.2014.02.011)
Holterman, C. E., Thibodeau, J.-F., Towaij, C., Gutsol, A., Montezano, A. C., Parks, R. J., Cooper, M. E., Touyz, R. M. and Kennedy, C. R.J. (2014) Nephropathy and elevated BP in mice with podocyte-specific NADPH oxidase 5 expression. Journal of the American Society of Nephrology, 25(4), pp. 784-797. (doi: 10.1681/ASN.2013040371)
Montezano, A. C., Nguyen Dinh Cat, A., Rios, F. J. and Touyz, R. M. (2014) Angiotensin II and vascular injury. Current Hypertension Reports, 16(6), p. 431. (doi: 10.1007/s11906-014-0431-2)
Montezano, A. C. and Touyz, R. M. (2014) Reactive oxygen species, vascular noxs, and hypertension: focus on translational and clinical research. Antioxidants and Redox Signaling, 20(1), pp. 164-182. (doi: 10.1089/ars.2013.5302)
Bruder‑Nascimento, T., Callera, G. E., Montezano, A. C., He, Y., Antunes, T. T., Nguyen Dinh Cat, A., Tostes, R. C. and Touyz, R. M. (2014) Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive nox-dependent pathways. Clinical Science, 128(7), pp. 411-423. (doi: 10.1042/CS20140456)
Yogi, A. et al. (2013) Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain. Cellular Signalling, 25(11), pp. 2163-2175. (doi: 10.1016/j.cellsig.2013.07.002)
Nguyen Dinh Cat, A., Montezano, A.C., Burger, D. and Touyz, R.M. (2013) Angiotensin II, NADPH oxidase, and redox signaling in the vasculature. Antioxidants and Redox Signaling, 19(10), pp. 1110-1120. (doi: 10.1089/ars.2012.4641)
Bruder-Nascimento, T., Callera, G. E., Montezano, A. C., He, Y., Antunes, T., de Cassia Tostes, R., Touyz, R. M. and , (2013) Atorvastatin Inhibits Src/ROS-mediated Redox Sensitive And Pro-Inflammatory Actions of Aldosterone in Vascular Smooth Muscle Cells: Focus on Statins Pleiotropic Effects. Hypertension, 62(3 Sup), A488.
Bruder-Nascimento, T., Callera, G. E., Montezano, A. C., He, Y., Nguyen Dinh Cat, A., de Cassia Tostes, R. and Touyz, R. M. (2013) Atorvastatin downregulates vascular nox expression and ameliorates oxidative stress-associated inflammatory process in type 2 diabetic Db/db mice. Hypertension, 62(3 Sup), A33.
Callera, G. E., Montezano, A. C., Bruder-Nascimento, T. and Touyz, R. M. (2013) Downregulation of C-terminal Src kinase (csk) and Csk-binding protein (cbp) is associated with increased aldosterone-induced C-src phosphorylation in Shr vascular smooth muscle cells. Hypertension, 62(3 Sup), A350.
Even, S. et al. (2013) The Nox4 inhibitor GKT137831, prevents aldosterone production by adipocytes and protects against adipose tissue inflammation and fibrosis in obese mice. Hypertension, 62(3 Sup), A74.
Hood, K. Y., Montezano, A. C., MacLean, M. R. and Touyz, R. M. (2013) Differential effects of 17ß-estradiol and 16a-hydroxyestrone in oxidative stress and proliferative responses in human pulmonary artery smooth muscle cells - implications in pulmonary arterial hypertension. Hypertension, 62(3 Sup), A263.
Hood, K. Y., Montezano, A. C., Morecroft, I., MacLean, M. R. and Touyz, R. M. (2013) Serotonin signaling through Nox1 in human pulmonary artery smooth muscle cells - implications in vascular remodeling in pulmonary arterial hypertension. Hypertension, 62(3 Sup), A264.
Montezano, A. C. et al. (2013) Nox4 inhibition, by GKT 137831, decreases obesity-associated vascular dysfunction and pro-fibrotic effects. Hypertension, 62(3 Sup), A491.
Montezano, A. C., Yusuf, H., Graham, D. and Touyz, R. M. (2013) Redox-sensitive osteogenic factors as novel mediators of vascular injury in hypertension. Hypertension, 62(3 Sup), A490.
Nguyen Dinh Cat, A., Callera, G. E., Antunes, T. T., He, Y., Montezano, A. C., Bruder-Nascimento, T. and Touyz, R. M. (2013) Mineralocorticoid Receptor and Rhoa/rho Kinase Contribute to Vascular Dysfunction in Obese Db/db Mice. Hypertension, 62(3 Sup), A373.
Nguyen Dinh Cat, A., Callera, G. E., Antunes, T. T., Montezano, A. C., He, Y., Jenkins, C., Carter, A., Jaisser, F. and Touyz, R. M. (2013) Altered vascular reactivity in mice overexpressing adipocyte mineralocorticoid receptors - role of oxidative stress and Rho kinase. Hypertension, 62(3 Sup), A66.
Nguyen Dinh Cat, A., Callera, G. E., Antunes, T. T., Montezano, A. C., Jenkins, C., Touyz, R. M. and He, Y. (2013) Upregulation of the mineralocorticoid system in obesity-associated diabetes leads to increased adipocyte Rho kinase activation and dysregulation of adipocytokines. Hypertension, 62(3 Sup), A372.
Rios, F. J. , Nguyen Dinh Cat, A., Palacios, R. , Carswell, A., Montezano, A. C. and Touyz, R. M. (2013) Torcetrapib and dalcetrapib, CETP inhibitors, induce adipocyte-derived aldosterone and reactive oxygen species formation. Hypertension, 62(3 Sup), A356.
Gray, S.P. et al. (2013) NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. Circulation, 127(18), pp. 1888-1902. (doi: 10.1161/CIRCULATIONAHA.112.132159)
Burger, D., Schock, S., Thompson, C.S., Montezano, A.C., Hakim, A.M. and Touyz, R.M. (2013) Microparticles: biomarkers and beyond. Clinical Science, 124(7), pp. 423-441. (doi: 10.1042/CS20120309)
Montezano, A.C. and Touyz, R.M. (2013) Mechanosensitive regulation of cortactin by p47phox: a new paradigm in cytoskeletal remodeling. Circulation Research, 112(12), pp. 1522-1525. (doi: 10.1161/CIRCRESAHA.113.301495)
Sedeek, M. et al. (2013) Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes. Clinical Science, 124(3), pp. 191-202. (doi: 10.1042/CS20120330)
Sedeek, M. et al. (2012) Oxidative stress, Nox isoforms and complications of diabetes—potential targets for novel therapies. Journal of Cardiovascular Translational Research, 5(4), pp. 509-518. (doi: 10.1007/s12265-012-9387-2)
Burger, D., Kwart, D. G., Montezano, A. C., Read, N. C., Kennedy, C. R.J., Thompson, C. S. and Touyz, R. M. (2012) Microparticles induce cell cycle arrest through redox-sensitive processes in endothelial cells: implications in vascular senescence. Journal of the American Heart Association, 1(3), e001842. (doi: 10.1161/JAHA.112.001842)
Chignalia, A. Z. et al. (2012) Testosterone induces vascular smooth muscle cell migration by NADPH oxidase and c-Src-dependent pathways. Hypertension, 59(6), pp. 1263-1271. (doi: 10.1161/HYPERTENSIONAHA.111.180620) (PMID:22566500)
Montezano, A.C. and Touyz, R.M. (2012) Oxidative stress, Noxs, and hypertension: experimental evidence and clinical controversies. Annals of Medicine, 44(S1), S2-S16. (doi: 10.3109/07853890.2011.653393)
Montezano, A.C. and Touyz, R.M. (2012) Molecular mechanisms of hypertension—reactive oxygen species and antioxidants: a basic science update for the clinician. Canadian Journal of Cardiology, 28(3), pp. 288-295. (doi: 10.1016/j.cjca.2012.01.017)
Montezano, A.C. (2012) Molecular mechanisms of hypertension—reactive oxygen species and antioxidants: a basic science update for the clinici. Canadian Journal of Cardiology, 28(3), pp. 288-295. (doi: 10.1016/j.cjca.2012.01.017)
Montezano, A.C. and Touyz, R.M. (2012) Reactive oxygen species and endothelial function - role of nitric oxide synthase uncoupling and nox family Nicotinamide Adenine Dinucleotide Phosphate oxidases. Basic and Clinical Pharmacology and Toxicology, 110(1), pp. 87-94. (doi: 10.1111/j.1742-7843.2011.00785.x)
Paravicini, T.M., Montezano, A.C., Yusuf, H. and Touyz, R.M. (2012) Activation of vascular p38MAPK by mechanical stretch is independent of c-Src and NADPH oxidase: influence of hypertension and angiotensin II. Journal of the American Society of Hypertension, 6(3), pp. 169-178. (doi: 10.1016/j.jash.2012.01.002)
Touyz, R.M. and Montezano, A.C. (2012) Vascular Nox4: a multifarious NADPH oxidase. Circulation Research, 110(9), pp. 1159-1161. (doi: 10.1161/CIRCRESAHA.112.269068)
White, M., Montezano, A.C. and Touyz, R.M. (2012) Angiotensin II signalling and calcineurin in cardiac fibroblasts: differential effects of calcineurin inhibitors FK506 and cyclosporine A. Therapeutic Advances in Cardiovascular Disease, 6(1), pp. 5-14. (doi: 10.1177/1753944711432901)
Cascino, T., Csanyi, G., Al Ghouleh, I., Montezano, A.C., Touyz, R.M. , Haurani, M.J. and Pagano, P.J. (2011) Adventitia-derived hydrogen peroxide impairs relaxation of the rat carotid artery via smooth muscle cell p38 mitogen-activated protein kinase. Antioxidants and Redox Signaling, 15(6), pp. 1507-1515. (doi: 10.1089/ars.2010.3631)
Callera, G.E., Yogi, A., Briones, A.M., Montezano, A.C., He, Y., Tostes, R.C.A., Schiffrin, E.L. and Touyz, R.M. (2011) Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: role of PDGFR. Cardiovascular Research, 91(4), pp. 720-731. (doi: 10.1093/cvr/cvr131) (PMID:21576132)
Touyz, R.M. , Briones, A.M., Sedeek, M., Burger, D. and Montezano, A.C. (2011) NOX isoforms and reactive oxygen species in vascular health. Molecular Interventions, 11(1), pp. 27-35. (doi: 10.1124/mi.11.1.5)
Briones, A.M., Tabet, F., Callera, G.E., Montezano, A.C., Yogi, A., He, Y., Quinn, M.T., Salaices, M. and Touyz, R.M. (2011) Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR. Journal of the American Society of Hypertension, 5(3), pp. 137-153. (doi: 10.1016/j.jash.2011.02.001)
Nguyen Dinh Cat, A., Briones, A.M., Callera, G.E., Yogi, A., He, Y., Montezano, A.C. and Touyz, R.M. (2011) Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors. Hypertension, 58(3), pp. 479-488. (doi: 10.1161/HYPERTENSIONAHA.110.168872)
Savoia, C.,, Burger, D., Nishigaki, N., Montezano, A. and Touyz, R.M. (2011) Angiotensin II and the vascular phenotype in hypertension. Expert Reviews in Molecular Medicine, 13(e11), pp. 1-25. (doi: 10.1017/S1462399411001815)
Montezano, A.C. et al. (2010) Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells. Circulation Research, 106(8), pp. 1363-1373. (doi: 10.1161/CIRCRESAHA.109.216036)
Montezano, A.C., Burger, D., Ceravolo, G.S., Yusuf, H., Montero, M. and Touyz, R.M. (2010) Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5. Clinical Science, 120(4), pp. 131-141. (doi: 10.1042/CS20100384)
Montezano, A.C., Zimmerman, D., Yusuf, H., Burger, D., Chignalia, A.Z., Wadhera, V., van Leeuwen, F.N. and Touyz, R.M. (2010) Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium. Hypertension, 56(3), pp. 453-462. (doi: 10.1161/HYPERTENSIONAHA.110.152058)
Touyz, R.M. and Montezano, A.C. (2009) Vascular smooth muscle cells sense calcium: a new paradigm in vascular calcification. Cardiovascular Research, 81(2), pp. 237-239. (doi: 10.1093/cvr/cvn345) (PMID:19088081)
Callera, G.E., He, Y., Yogi, A., Montezano, A.C., Paravicini, T., Yao, G. and Touyz, R.M. (2009) Regulation of the novel Mg2+ transporter transient receptor potential melastatin 7 (TRPM7) cation channel by bradykinin in vascular smooth muscle cells. Journal of Hypertension, 27(1), pp. 155-166. (doi: 10.1097/HJH.0b013e3283190582)
Montezano, A.C., Callera, G.E., Yogi, A., He, Y., Tostes, R.C., He, G., Schiffrin, E.L. and Touyz, R.M. (2008) Aldosterone and Angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(8), pp. 1511-1518. (doi: 10.1161/ATVBAHA.108.168021)
Montezano, A.C. and Touyz, R.M. (2008) Networking between systemic Angiotensin II and cardiac mineralocorticoid receptors. Hypertension, 52(6), pp. 1016-1018. (doi: 10.1161/HYPERTENSIONAHA.108.121269)
Sontia, B., Montezano, A.C., Paravicini, T., Tabet, F. and Touyz, R.M. (2008) Downregulation of renal TRPM7 and increased inflammation and fibrosis in aldosterone-infused mice: effects of magnesium. Hypertension, 51(4), pp. 915-921. (doi: 10.1161/HYPERTENSIONAHA.107.100339)
Yogi, A., Mercure, C., Touyz, J., Callera, G.E., Montezano, A.C., Aranha, A.B., Tostes, R.C., Reudelhuber, T. and Touyz, R.M. (2008) Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in Angiotensin II-dependent chronic hypertension. Hypertension, 51(2), pp. 500-506. (doi: 10.1161/HYPERTENSIONAHA.107.103192)
Montezano, A.C., Amiri, F., Tostes, R.C., Touyz, R.M. and Schiffrin, E.L. (2007) Inhibitory effects of PPAR-γ on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats. Journal of the American Society of Hypertension, 1(2), pp. 150-160. (doi: 10.1016/j.jash.2007.01.005)
Touyz, R.M. , Savoia, C., He, Y., Endemann, D., Pu, Q., Ko, E.A., DeCiuceis, C., Montezano, A.C. and Schiffrin, E.L. (2007) Increased inflammatory biomarkers in hypertensive type 2 diabetic patients: improvement after angiotensin II type 1 receptor blockade. Journal of the American Society of Hypertension, 1(3), pp. 189-199. (doi: 10.1016/j.jash.2007.01.009)
Yogi, A., Callera, G.E., Montezano, A.C., Aranha, A.B., Tostes, R.C., Schiffrin, E.L. and Touyz, R.M. (2007) Endothelin-1, but not Ang II, activates MAP kinases through c-Src-independent Ras-Raf-dependent pathways in vascular smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(9), pp. 1960-1967. (doi: 10.1161/ATVBAHA.107.146746)
Callera, G.E., Tostes, R.C., Yogi, A., Montezano, A.C. and Touyz, R.M. (2006) Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms. Clinical Science, 110(2), pp. 243-253. (doi: 10.1042/CS20050307)
Touyz, R.M. , He, Y., Montezano, A.C., Yao, G., Chubanov, V., Gudermann, T. and Callera, G.E. (2006) Differential regulation of transient receptor potential melastatin 6 and 7 cation channels by ANG II in vascular smooth muscle cells from spontaneously hypertensive rats. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 290(1), R73-R78. (doi: 10.1152/ajpregu.00515.2005)
Callera, G. E., Montezano, A.C., Alvaro, Y., Tostes, R.C., He, Y., Schriffin, E. and Touyz, R.M. (2005) c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats. Hypertension, 46(4), pp. 1032-1038. (doi: 10.1161/01.HYP.0000176588.51027.35)
Callera, G.E., Montezano, A.C., Touyz, R.M. , Zorn, T.M.T., Carvalho, M.H., Fortes, Z.B., Nigro, D., Schriffin, E.L. and Tostes, R.C. (2004) ETA receptor mediates altered leukocyte-endothelial cell interaction and adhesion molecules expression in DOCA-salt rats. Hypertension, 43(4), pp. 872-879. (doi: 10.1161/01.HYP.0000117296.30296.14)
Books
Montezano, A.C. and Touyz, R.M. (2012) Reactive Oxygen Species and the Cardiovascular System. Series: Integrated systems physiology. Morgan & Claypool. ISBN 9781615043620
Book Sections
Alves-Lopes, R. , Touyz, R. M. and Montezano, A. C. (2019) Cell biology of vessels. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 23-30. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_3)
Rios, F. J. , Touyz, R. M. , Montezano, A. C. and Burger, D. (2019) Microparticles and exosomes in cell-cell communication. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 159-168. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_15)
Rios, F. J. , Touyz, R. M. and Montezano, A. C. (2017) Isolation and differentiation of human macrophages. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology, 1527. Springer: New York, pp. 311-320. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_24)
Montezano, A. C., Lopes, R. A.M. , Neves, K. B. , Rios, F. and Touyz, R. M. (2017) Isolation and culture of vascular smooth muscle cells from small and large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 349-354. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_27)
Montezano, A. C., Neves, K. B. , Lopes, R. A.M. and Rios, F. (2017) Isolation and culture of endothelial cells from large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 345-348. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_26)
Rios, F. J. , Touyz, R. M. and Montezano, A. C. (2017) Isolation and differentiation of murine macrophages. In: Touyz, R. M. and Shiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology. Humana Press, pp. 297-309. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_23)
Rios, F. J. , Montezano, A. C., Antunes, T. T. and Touyz, R. M. (2016) Magnesium, vascular function, and hypertension. In: Collins, J. F. (ed.) Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Academic Press, pp. 353-364. ISBN 9780128021682 (doi: 10.1016/B978-0-12-802168-2.00029-4)
Tsiropoulou, S., Dulak-Lis, M., Montezano, A. C. and Touyz, R. M. (2016) Biomarkers of oxidative stress in human hypertension. In: Andreadis, E. A. (ed.) Hypertension and Cardiovascular Disease. Springer, pp. 151-170. ISBN 9783319395975 (doi: 10.1007/978-3-319-39599-9_11)
Montezano, A. C., Nguyen Dinh Cat, A. and Touyz, R. M. (2015) Mas signaling: resolved and unresolved issues. In: Unger, T., Steckelings, U. M. and dos Santos, R. A.S. (eds.) The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications. Academic Press, pp. 169-179. ISBN 9780128013649 (doi: 10.1016/B978-0-12-801364-9.00023-7)
Welsh, P. , Preiss, D. , Tsiropoulou, S., Rios, F. J. , Harvey, A., Dulak-Lis, M. G., Montezano, A. C. and Touyz, R. M. (2015) Biomarkers of vascular inflammation and cardiovascular disease. In: Berbari, A. and Mancia, G. (eds.) Arterial Disorders: Definition, Clinical Manifestations, Mechanisms and Therapeutic Approaches. Springer: Cham, pp. 115-136. ISBN 9783319145556 (doi: 10.1007/978-3-319-14556-3_9)
Montezano, A. C. and Touyz, R. M. (2014) Reactive oxygen species, vascular disease, and hypertension. In: Laher, I. (ed.) Systems Biology of Free Radicals and Antioxidants. Springer: Berlin, Heidelberg, pp. 1123-1154. ISBN 9783642300172 (doi: 10.1007/978-3-642-30018-9_56)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Characterising vascular pathophysiology in CADASIL (cerebral autosomal dominant arteriopathy with subacute infarcts and leukoencephalopathy) by evaluation of gluteal resistance vessels
Stroke Association
2013 - 2016
Supervision
- Blaikie, Zachariel
Determining the role of NADPH oxidase 5 in stroke, cerebral small vessel disease, and vascular dementia
