2024

Cooke, S. F. et al. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, 8998. (doi: 10.1038/s41598-024-59451-3) (PMID:38637546)

2020

Ngandu Mpoyi, E. et al. (2020) Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts. Biomaterials, 252, 120090. (doi: 10.1016/j.biomaterials.2020.120090) (PMID:32413593)

2019

Gatseva, A. , Sin, Y. Y., Brezzo, G. and Van Agtmael, T. (2019) Basement membrane collagens and disease mechanisms. Essays in Biochemistry, 63(3), pp. 297-312. (doi: 10.1042/EBC20180071) (PMID:31387942) (PMCID:PMC6744580)

2018

Sin, Y. Y., Ballantyne, L. L., Richmond, C. R. and Funk, C. D. (2018) Transplantation of gene-edited hepatocyte-like cells modestly improves survival of arginase-1 deficient mice. Molecular Therapy - Nucleic Acids, 10, pp. 122-130. (doi: 10.1016/j.omtn.2017.11.012)

2017

Sin, Y. Y., Price, P. R., Ballantyne, L. L. and Funk, C. D. (2017) Proof-of-concept gene editing for the murine model of inducible arginase-1 deficiency. Scientific Reports, 7, 2585. (doi: 10.1038/s41598-017-02927-2) (PMID:28566761) (PMCID:PMC5451454)

2016

Ballantyne, L. L., Sin, Y. Y., Al-Dirbashi, O. Y., Li, X., Hurlbut, D. J. and Funk, C. D. (2016) Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency. Molecular Genetics and Metabolism Reports, 9, pp. 54-60. (doi: 10.1016/j.ymgmr.2016.10.003) (PMID:27761413) (PMCID:PMC5065044)

2015

Sin, Y. Y., Baron, G., Schulze, A. and Funk, C. D. (2015) Arginase-1 deficiency. Journal of Molecular Medicine, 93(12), pp. 1287-1296. (doi: 10.1007/s00109-015-1354-3) (PMID:26467175)

Sin, Y. Y. and Baillie, G. (2015) Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1). Cell Biochemistry and Function, 33(7), pp. 421-426. (doi: 10.1002/cbf.3147) (PMID:26443497) (PMCID:PMC4973849)

Zoccarato, A. et al. (2015) Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2. Circulation Research, 117, pp. 707-719. (doi: 10.1161/CIRCRESAHA.114.305892) (PMID:26243800)

Ballantyne, L. L., Sin, Y. Y., St. Amand, T., Si, J., Goossens, S., Haenebalcke, L., Haigh, J. J., Kyriakopoulou, L., Schulze, A. and Funk, C. D. (2015) Strategies to rescue the consequences of inducible arginase-1 deficiency in mice. PLoS ONE, 10(5), e0125967. (doi: 10.1371/journal.pone.0125967) (PMID:25938595) (PMCID:PMC4418594)

Sin, Y. Y., Martin, T. P. , Wills, L., Currie, S. and Baillie, G. S. (2015) Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. Cell Communication and Signaling, 13, 16. (doi: 10.1186/s12964-015-0094-x) (PMID:25889640) (PMCID:PMC4356135)

2013

Sin, Y. Y., Ballantyne, L. L., Mukherjee, K., St. Amand, T., Kyriakopoulou, L., Schulze, A. and Funk, C. D. (2013) Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism. PLoS ONE, 8(11), e80001. (doi: 10.1371/journal.pone.0080001) (PMID:24224027) (PMCID:PMC3817112)

Berthouze-Duquesnes, M., Lucas, A., Saulière, A., Sin, Y.Y., Laurent, A.C., Galés, C., Baillie, G. and Lezoualc'h, F. (2013) Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling. Cellular Signalling, 25(4), pp. 970-980. (doi: 10.1016/j.cellsig.2012.12.007) (PMID:23266473)

2012

Sin, Y. Y. and Baillie, G. S. (2012) Protein kinase D in the hypertrophy pathway. Biochemical Society Transactions, 40(1), pp. 287-289. (doi: 10.1042/BST20110626) (PMID:22260707)

2011

Sin, Y.Y., Edwards, H.V., Li, X., Day, J.P., Christian, F. , Dunlop, A.J., Adams, D.R., Zaccolo, M., Houslay, M.D. and Baillie, G.S. (2011) Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes. Journal of Molecular and Cellular Cardiology, 50(5), pp. 872-883. (doi: 10.1016/j.yjmcc.2011.02.006) (PMID:21334344)

Anthony, D.F., Sin, Y.Y., Vadrevu, S., Advant, N., Day, J.P., Byrne, A.M., Lynch, M.J., Milligan, G. , Houslay, M.D. and Baillie, G.S. (2011) β-Arrestin 1 inhibits the GAP function of ARHGAP21 so as to promote the activation of RhoA following angiotensin II type 1A receptor stimulation. Molecular and Cellular Biology, 31(5), pp. 1066-1075. (doi: 10.1128/MCB.00883-10) (PMID:21173159) (PMCID:PMC3067824)

2006

Harris, T. P., Gomas, K. P., Weir, F., Holyoake, A. J., McHugh, P., Wu, M., Sin, Y., Sin, I. L. and Sin, F. Y. T. (2006) Molecular analysis of polymerase gamma gene and mitochondrial polymorphism in fertile and subfertile men. International Journal of Andrology, 29(3), pp. 421-433. (doi: 10.1111/j.1365-2605.2005.00633.x) (PMID:16487403)

Articles

Cooke, S. F. et al. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, 8998. (doi: 10.1038/s41598-024-59451-3) (PMID:38637546)

Ngandu Mpoyi, E. et al. (2020) Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts. Biomaterials, 252, 120090. (doi: 10.1016/j.biomaterials.2020.120090) (PMID:32413593)

Gatseva, A. , Sin, Y. Y., Brezzo, G. and Van Agtmael, T. (2019) Basement membrane collagens and disease mechanisms. Essays in Biochemistry, 63(3), pp. 297-312. (doi: 10.1042/EBC20180071) (PMID:31387942) (PMCID:PMC6744580)

Sin, Y. Y., Ballantyne, L. L., Richmond, C. R. and Funk, C. D. (2018) Transplantation of gene-edited hepatocyte-like cells modestly improves survival of arginase-1 deficient mice. Molecular Therapy - Nucleic Acids, 10, pp. 122-130. (doi: 10.1016/j.omtn.2017.11.012)

Sin, Y. Y., Price, P. R., Ballantyne, L. L. and Funk, C. D. (2017) Proof-of-concept gene editing for the murine model of inducible arginase-1 deficiency. Scientific Reports, 7, 2585. (doi: 10.1038/s41598-017-02927-2) (PMID:28566761) (PMCID:PMC5451454)

Ballantyne, L. L., Sin, Y. Y., Al-Dirbashi, O. Y., Li, X., Hurlbut, D. J. and Funk, C. D. (2016) Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency. Molecular Genetics and Metabolism Reports, 9, pp. 54-60. (doi: 10.1016/j.ymgmr.2016.10.003) (PMID:27761413) (PMCID:PMC5065044)

Sin, Y. Y., Baron, G., Schulze, A. and Funk, C. D. (2015) Arginase-1 deficiency. Journal of Molecular Medicine, 93(12), pp. 1287-1296. (doi: 10.1007/s00109-015-1354-3) (PMID:26467175)

Sin, Y. Y. and Baillie, G. (2015) Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1). Cell Biochemistry and Function, 33(7), pp. 421-426. (doi: 10.1002/cbf.3147) (PMID:26443497) (PMCID:PMC4973849)

Zoccarato, A. et al. (2015) Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2. Circulation Research, 117, pp. 707-719. (doi: 10.1161/CIRCRESAHA.114.305892) (PMID:26243800)

Ballantyne, L. L., Sin, Y. Y., St. Amand, T., Si, J., Goossens, S., Haenebalcke, L., Haigh, J. J., Kyriakopoulou, L., Schulze, A. and Funk, C. D. (2015) Strategies to rescue the consequences of inducible arginase-1 deficiency in mice. PLoS ONE, 10(5), e0125967. (doi: 10.1371/journal.pone.0125967) (PMID:25938595) (PMCID:PMC4418594)

Sin, Y. Y., Martin, T. P. , Wills, L., Currie, S. and Baillie, G. S. (2015) Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. Cell Communication and Signaling, 13, 16. (doi: 10.1186/s12964-015-0094-x) (PMID:25889640) (PMCID:PMC4356135)

Sin, Y. Y., Ballantyne, L. L., Mukherjee, K., St. Amand, T., Kyriakopoulou, L., Schulze, A. and Funk, C. D. (2013) Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism. PLoS ONE, 8(11), e80001. (doi: 10.1371/journal.pone.0080001) (PMID:24224027) (PMCID:PMC3817112)

Berthouze-Duquesnes, M., Lucas, A., Saulière, A., Sin, Y.Y., Laurent, A.C., Galés, C., Baillie, G. and Lezoualc'h, F. (2013) Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling. Cellular Signalling, 25(4), pp. 970-980. (doi: 10.1016/j.cellsig.2012.12.007) (PMID:23266473)

Sin, Y. Y. and Baillie, G. S. (2012) Protein kinase D in the hypertrophy pathway. Biochemical Society Transactions, 40(1), pp. 287-289. (doi: 10.1042/BST20110626) (PMID:22260707)

Sin, Y.Y., Edwards, H.V., Li, X., Day, J.P., Christian, F. , Dunlop, A.J., Adams, D.R., Zaccolo, M., Houslay, M.D. and Baillie, G.S. (2011) Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes. Journal of Molecular and Cellular Cardiology, 50(5), pp. 872-883. (doi: 10.1016/j.yjmcc.2011.02.006) (PMID:21334344)

Anthony, D.F., Sin, Y.Y., Vadrevu, S., Advant, N., Day, J.P., Byrne, A.M., Lynch, M.J., Milligan, G. , Houslay, M.D. and Baillie, G.S. (2011) β-Arrestin 1 inhibits the GAP function of ARHGAP21 so as to promote the activation of RhoA following angiotensin II type 1A receptor stimulation. Molecular and Cellular Biology, 31(5), pp. 1066-1075. (doi: 10.1128/MCB.00883-10) (PMID:21173159) (PMCID:PMC3067824)

Harris, T. P., Gomas, K. P., Weir, F., Holyoake, A. J., McHugh, P., Wu, M., Sin, Y., Sin, I. L. and Sin, F. Y. T. (2006) Molecular analysis of polymerase gamma gene and mitochondrial polymorphism in fertile and subfertile men. International Journal of Andrology, 29(3), pp. 421-433. (doi: 10.1111/j.1365-2605.2005.00633.x) (PMID:16487403)