Dr Donald Lyall

  • Lecturer in Public Health (Public Health)

Biography

Donald is a lecturer in Public Health. He is an epidemiologist, and his research aims to understand how genes, environment and their interaction (GxE) influence human brain health. He is deputy lead for Psychology, for SINAPSE, and Review Editor for Frontiers in Psychiatry and Genetics.  

Dr. Lyall has published 1st author papers in journals like European Heart Journal, Translational Psychiatry and JAMA Cardiology, and presented his work publicly in places like Pint of Science and Café Scientifique.

 

Background

BSc Psychology (2004-2008; University of Stirling)

MSc Human Cognitive Neuropsychology (2009; University of Edinburgh)

Assistant Clinical Psychology (2010; NHS Greater Glasgow and Clyde)

PhD 'Genetic contributions to cognitive ageing and structural brain MRI phenotypes' (2010-2013; University of Edinburgh)

Postdoctoral research fellow (2013-2014; Johns Hopkins University/National Institute on Aging)

Research Associate (2014-2017; University of Glasgow)

Lecturer (2017 to date; University of Glasgow). 


Research interests

Click here for more information on our group's programme of work using UK Biobank data. A good example of Donald's research is this study, which investigates how a genetic risk factor for Alzheimer's disease associates with cognitive ability via brain white matter tract integrity.


Publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013
Number of items: 56.

2019

Shaw, R. J. , Cullen, B. , Graham, N., Lyall, D. M. , Mackay, D. , Okolie, C., Pearsall, R., Ward, J., John, A. and Smith, D. J. (2019) Living alone, loneliness and lack of emotional support as predictors of suicide and self-harm: seven-year follow up of the UK Biobank cohort. medRxiv, (doi:10.1101/19008458)

Ho, F. K.W. et al. (2019) The association between handgrip strength and future health outcomes does not differ if grip strength is used in absolute or relative terms: a prospective cohort study. Age and Ageing, 48(5), pp. 683-691. (doi:10.1093/ageing/afz068) (PMID:31204772)

Welsh, C. et al. (2019) Comparison of conventional lipoprotein tests and apolipoproteins in the prediction of cardiovascular disease: data from UK Biobank. Circulation, 140(7), pp. 542-552. (doi:10.1161/CIRCULATIONAHA.119.041149) (PMID:31216866)

Gray, S. et al. (2019) Do physical activity, commuting mode, cardiorespiratory fitness and sedentary behaviours modify the genetic predisposition to higher BMI? Findings from a UK Biobank study. International Journal of Obesity, 43, pp. 1526-1538. (doi:10.1038/s41366-019-0381-5) (PMID:31168053)

Lyall, L. M., Cullen, B. , Lyall, D. M. , Leighton, S. P. , Siebert, S. , Smith, D. J. and Cavanagh, J. (2019) The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank. European Psychiatry, 60, pp. 63-70. (doi:10.1016/j.eurpsy.2019.05.007) (PMID:31158611)

Cox, S.R. et al. (2019) Associations between vascular risk factors and brain MRI indices in UK Biobank. European Heart Journal, 40(28), pp. 2290-2300. (doi:10.1093/eurheartj/ehz100) (PMID:30854560) (PMCID:PMC6642726)

Ward, J. et al. (2019) The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. Molecular Psychiatry, (doi:10.1038/s41380-019-0439-8) (PMID:31168069) (Early Online Publication)

Lyall, D. M. et al. (2019) Assessing for interaction between APOE ε4, sex and lifestyle on cognitive abilities. Neurology, 92, e2691-e2698. (doi:10.1212/WNL.0000000000007551) (PMID:31028125) (PMCID:PMC6556094)

Ferguson, L. D. , Brown, R., Celis-Morales, C. , Welsh, P. , Lyall, D. M. , Pell, J. P. , McInnes, I. B. , Siebert, S. and Sattar, N. (2019) Association of central adiposity with psoriasis, psoriatic arthritis and rheumatoid arthritis: a cross-sectional study of the UK Biobank. Rheumatology, (doi:10.1093/rheumatology/kez192) (PMID:31131407) (Early Online Publication)

Morris, J. et al. (2019) Genetic variation in CADM2 as a link between psychological traits and obesity. Scientific Reports, 9, 7339. (doi:10.1038/s41598-019-43861-9) (PMID:31089183) (PMCID:PMC6517397)

Sillars, A. et al. (2019) Association of fitness and grip-strength with heart failure: Findings from the UK Biobank population-based study. Mayo Clinic Proceedings, (Accepted for Publication)

Welsh, C. et al. (2019) Urinary sodium excretion, blood pressure and risk of future cardiovascular disease and mortality in subjects without prior cardiovascular disease. Hypertension, (doi:10.1161/HYPERTENSIONAHA.119.12726) (Early Online Publication)

Celis-Morales, C. A. et al. (2019) The combination of physical activity and sedentary behaviors modifies the genetic predisposition to obesity. Obesity, 27(4), pp. 653-661. (doi:10.1002/oby.22417) (PMID:30900409)

Lyall, D. M. et al. (2019) Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity. Brain Imaging and Behavior, (doi:10.1007/s11682-019-00069-9) (PMID:30903549) (Early Online Publication)

Celis-Morales, C. A. et al. (2019) Walking pace is associated with lower risk of all-cause and cause-specific mortality. Medicine and Science in Sports and Exercise, 51(3), pp. 472-480. (doi:10.1249/MSS.0000000000001795) (PMID:30303933)

Strawbridge, R. J. et al. (2019) Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide. EBioMedicine, 41, pp. 517-525. (doi:10.1016/j.ebiom.2019.02.005) (PMID:30745170) (PMCID:PMC6442001)

2018

Celis-Morales, C.A. et al. (2018) Associations of dietary protein intake with fat free mass and grip strength: cross-sectional study in 146,816 UK Biobank participants. American Journal of Epidemiology, 187(11), pp. 2405-2414. (doi:10.1093/aje/kwy134) (PMID:29961893)

Wyse, C. A. et al. (2018) Population-level seasonality in cardiovascular mortality, blood pressure, BMI and inflammatory cells in UK Biobank. Annals of Medicine, 50(5), pp. 410-419. (doi:10.1080/07853890.2018.1472389) (PMID:29724143)

Mackay, A., Mackay, D.F. , Celis-Morales, C.A. , Lyall, D.M. , Gray, S.R. , Sattar, N. , Gill, J.M.R. , Pell, J.P. and Anderson, J.J. (2018) The association between driving time and unhealthy lifestyles: a cross-sectional, general population study of 386 493 UK Biobank participants. Journal of Public Health, (doi:10.1093/pubmed/fdy155) (PMID:30239914) (Early Online Publication)

Strawbridge, R. et al. (2018) Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. Translational Psychiatry, 8, 178. (doi:10.1038/s41398-018-0236-1) (PMID:30181555) (PMCID:PMC6123450)

Ferguson, A. et al. (2018) Genome-wide association study of circadian rhythmicity in 71,500 UK Biobank participants and polygenic association with mood instability. EBioMedicine, 35, pp. 279-287. (doi:10.1016/j.ebiom.2018.08.004) (PMID:30120083) (PMCID:PMC6154782)

Cullen, B. , Newby, D., Lee, D. , Lyall, D. M. , Nevado-Holgado, A. J., Evans, J. J. , Pell, J. P. , Lovestone, S. and Cavanagh, J. (2018) Cross-sectional and longitudinal analyses of outdoor air pollution exposure and cognitive function in UK Biobank. Scientific Reports, 8, 12089. (doi:10.1038/s41598-018-30568-6) (PMID:30108252) (PMCID:PMC6092329)

Lyall, L. M. et al. (2018) Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank. Lancet Psychiatry, 5(6), pp. 507-514. (doi:10.1016/S2215-0366(18)30139-1) (PMID:29776774)

Welsh, C. et al. (2018) Association of total and differential leukocyte counts with cardiovascular disease and mortality in the UK Biobank. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(6), pp. 1415-1423. (doi:10.1161/ATVBAHA.118.310945) (PMID:29699973)

Celis-Morales, C. et al. (2018) Associations of discretionary screen time with mortality, cardiovascular disease and cancer are attenuated by strength, fitness and physical activity: findings from the UK Biobank study. BMC Medicine, 16, 77. (doi:10.1186/s12916-018-1063-1) (PMID:29792209) (PMCID:PMC5966877)

Zhou, A. et al. (2018) Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants. Scientific Reports, 8, 7526. (doi:10.1038/s41598-018-25919-2) (PMID:29760501) (PMCID:PMC5951917)

Celis-Morales, C. A. et al. (2018) Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants. British Medical Journal, 361, k1651. (doi:10.1136/bmj.k1651) (PMID:29739772) (PMCID:PMC5939721)

Iliodromiti, S. et al. (2018) The impact of confounding on the associations of different adiposity measures with the incidence of cardiovascular disease: a cohort study of 296 535 adults of white European descent. European Heart Journal, 39(17), pp. 1514-1520. (doi:10.1093/eurheartj/ehy057) (PMID:29718151) (PMCID:PMC5930252)

Vaucher, J. et al. (2018) Cannabis use and risk of schizophrenia: a Mendelian randomization study. Molecular Psychiatry, 23(5), pp. 1287-1292. (doi:10.1038/mp.2016.252) (PMID:28115737) (PMCID:PMC5984096)

Lyall, L. M. et al. (2018) Seasonality of depressive symptoms in women but not in men: a cross-sectional study in the UK Biobank cohort. Journal of Affective Disorders, 229, pp. 296-305. (doi:10.1016/j.jad.2017.12.106) (PMID:29329063)

Strawbridge, R. J. et al. (2018) Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort. Translational Psychiatry, 8, 39. (doi:10.1038/s41398-017-0079-1) (PMID:29391395) (PMCID:PMC5804026)

Anderson, J. J. , Darwis, N. D.M., Mackay, D. F. , Celis-Morales, C. , Lyall, D. M. , Sattar, N. , Gill, J. M.R. and Pell, J. P. (2018) Red and processed meat consumption and breast cancer: UK Biobank cohort study and meta-analysis. European Journal of Cancer, 90, pp. 73-82. (doi:10.1016/j.ejca.2017.11.022)

2017

Celis-Morales, C. A. et al. (2017) Associations between diabetes and both cardiovascular disease and all-cause mortality are modified by grip strength: evidence from UK Biobank, a prospective population-based cohort study. Diabetes Care, 40(12), pp. 1710-1718. (doi:10.2337/dc17-0921) (PMID:28986505)

Ward, J. et al. (2017) Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia. Translational Psychiatry, 7, 1264. (doi:10.1038/s41398-017-0012-7) (PMID:29187730) (PMCID:PMC5802589)

Howard, D. M. et al. (2017) Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank. Wellcome Open Research, 2, 61. (doi:10.12688/wellcomeopenres.12171.1) (PMID:28989979) (PMCID:PMC5605947)

Lyall, D. M. et al. (2017) Association of body mass index with cardiometabolic disease in the UK Biobank: a Mendelian randomization study. JAMA Cardiology, 2(8), pp. 882-889. (doi:10.1001/jamacardio.2016.5804) (PMID:28678979) (PMCID:PMC5710596)

Celis-Morales, C. A. et al. (2017) Association between active commuting and incident cardiovascular disease, cancer, and mortality: prospective cohort study. BMJ, 357, j1456. (doi:10.1136/bmj.j1456) (PMID:28424154)

Anderson, J.J. , Celis, C.A. , Mackay, D.F. , Iliodromiti, S., Lyall, D.M. , Sattar, N. , Gill, J.M.R. and Pell, J.P. (2017) Adiposity among 132 479 UK Biobank participants; contribution of sugar intake vs other macronutrients. International Journal of Epidemiology, 46(2), pp. 492-501. (doi:10.1093/ije/dyw173) (PMID:27407038) (PMCID:PMC5837311)

Celis-Morales, C. et al. (2017) Sleep characteristics modify the association between genetic predisposition to obesity and anthropometric measurements in 119,679 UK Biobank participants. American Journal of Clinical Nutrition, 105(4), pp. 980-990. (doi:10.3945/ajcn.116.147231)

Lyall, D. M. , Celis-Morales, C. A. , Anderson, J. , Gill, J. M.R. , Mackay, D. F. , McIntosh, A. M., Smith, D. J. , Deary, I. J., Sattar, N. and Pell, J. P. (2017) Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants. European Heart Journal, 38(8), pp. 577-583. (doi:10.1093/eurheartj/ehw528) (PMID:28363219)

Schmidt, A. F. et al. (2017) PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. Lancet Diabetes and Endocrinology, 5(2), pp. 97-105. (doi:10.1016/S2213-8587(16)30396-5) (PMID:27908689) (PMCID:PMC5266795)

Celis-Morales, C. A. , Lyall, D. M. , Anderson, J. , Iliodromiti, S., Fan, Y., Ntuk, U. E., Mackay, D. F. , Pell, J. P. , Sattar, N. and Gill, J. M.R. (2017) The association between physical activity and risk of mortality is modulated by grip strength and cardiorespiratory fitness: evidence from 498 135 UK-Biobank participants. European Heart Journal, 38(2), pp. 116-122. (doi:10.1093/eurheartj/ehw249) (PMID:28158566)

Celis-Morales, C. et al. (2017) Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants. International Journal of Obesity, 41, pp. 1761-1768. (doi:10.1038/ijo.2017.169) (PMID:28736445)

2016

Lyall, D. M. et al. (2016) Body-mass index and cardiometabolic disease: a Mendelian randomisation study of UK Biobank Participants. Lancet, 388(S2), S9-S9. (doi:10.1016/S0140-6736(16)32245-0)

Lyall, D. M. et al. (2016) Alzheimer disease genetic risk factor APOE e4, and cognitive abilities in 111,739 UK Biobank participants. Age and Ageing, 45(4), pp. 511-517. (doi:10.1093/ageing/afw068) (PMID:27103599)

Davies, G. et al. (2016) Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151). Molecular Psychiatry, 21, pp. 758-767. (doi:10.1038/mp.2016.45)

Lyall, D. M. et al. (2016) Cognitive test scores in UK Biobank: data reduction in 480,416 participants and longitudinal stability in 20,346 participants. PLoS ONE, 11(4), e0154222. (doi:10.1371/journal.pone.0154222) (PMID:27110937) (PMCID:PMC4844168)

Lyall, D. , Mackay, D. , Pell, J. and Smith, D. (2016) Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort. BJPsych Open, 2(1), pp. 38-44. (doi:10.1192/bjpo.bp.115.002154) (PMID:27703752) (PMCID:PMC4995581)

Siebert, S. , Lyall, D. M. , Mackay, D. F. , Porter, D. and McInnes, I. B. (2016) Characteristics of rheumatoid arthritis and its association with major comorbid conditions: cross-sectional study of 502 649 UK Biobank participants. RMD Open, 2(1), e000267. (doi:10.1136/rmdopen-2016-000267) (PMID:27403335) (PMCID:PMC4932291)

Smith, D.J. et al. (2016) Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci. Molecular Psychiatry, 21(6), pp. 749-757. (doi:10.1038/mp.2016.49) (PMID:27067015)

2015

Lyall, D. M. et al. (2015) APOE/TOMM40genetic loci, white matter hyperintensities, and cerebral microbleeds. International Journal of Stroke, 10(8), pp. 1297-1300. (doi:10.1111/ijs.12615) (PMID:26310205)

Nicholl, B. et al. (2015) Ethnic differences in the association between depression and chronic pain: cross sectional results from UK Biobank. BMC Family Practice, 16, 128. (doi:10.1186/s12875-015-0343-5) (PMID:26445480) (PMCID:PMC4596418)

2014

Lyall, D. M. et al. (2014) Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936. Neurobiology of Aging, 35(6), 1513.e25-1513.e33. (doi:10.1016/j.neurobiolaging.2014.01.006)

Lyall, D.M. et al. (2014) Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity? Translational Psychiatry, 4(9), e449. (doi:10.1038/tp.2014.89)

2013

Lyall, D. M. et al. (2013) Alzheimer’s disease susceptibility genes APOE and TOMM40, and hippocampal Volumes in the Lothian Birth Cohort 1936. PLoS ONE, 8(11), e80513. (doi:10.1371/journal.pone.0080513) (PMID:24260406) (PMCID:PMC3829876)

Lyall, D. M. et al. (2013) ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936. Behavior Genetics, 43(1), pp. 13-23. (doi:10.1007/s10519-012-9570-x)

This list was generated on Mon Oct 14 10:02:24 2019 BST.
Jump to: Articles
Number of items: 56.

Articles

Shaw, R. J. , Cullen, B. , Graham, N., Lyall, D. M. , Mackay, D. , Okolie, C., Pearsall, R., Ward, J., John, A. and Smith, D. J. (2019) Living alone, loneliness and lack of emotional support as predictors of suicide and self-harm: seven-year follow up of the UK Biobank cohort. medRxiv, (doi:10.1101/19008458)

Ho, F. K.W. et al. (2019) The association between handgrip strength and future health outcomes does not differ if grip strength is used in absolute or relative terms: a prospective cohort study. Age and Ageing, 48(5), pp. 683-691. (doi:10.1093/ageing/afz068) (PMID:31204772)

Welsh, C. et al. (2019) Comparison of conventional lipoprotein tests and apolipoproteins in the prediction of cardiovascular disease: data from UK Biobank. Circulation, 140(7), pp. 542-552. (doi:10.1161/CIRCULATIONAHA.119.041149) (PMID:31216866)

Gray, S. et al. (2019) Do physical activity, commuting mode, cardiorespiratory fitness and sedentary behaviours modify the genetic predisposition to higher BMI? Findings from a UK Biobank study. International Journal of Obesity, 43, pp. 1526-1538. (doi:10.1038/s41366-019-0381-5) (PMID:31168053)

Lyall, L. M., Cullen, B. , Lyall, D. M. , Leighton, S. P. , Siebert, S. , Smith, D. J. and Cavanagh, J. (2019) The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank. European Psychiatry, 60, pp. 63-70. (doi:10.1016/j.eurpsy.2019.05.007) (PMID:31158611)

Cox, S.R. et al. (2019) Associations between vascular risk factors and brain MRI indices in UK Biobank. European Heart Journal, 40(28), pp. 2290-2300. (doi:10.1093/eurheartj/ehz100) (PMID:30854560) (PMCID:PMC6642726)

Ward, J. et al. (2019) The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. Molecular Psychiatry, (doi:10.1038/s41380-019-0439-8) (PMID:31168069) (Early Online Publication)

Lyall, D. M. et al. (2019) Assessing for interaction between APOE ε4, sex and lifestyle on cognitive abilities. Neurology, 92, e2691-e2698. (doi:10.1212/WNL.0000000000007551) (PMID:31028125) (PMCID:PMC6556094)

Ferguson, L. D. , Brown, R., Celis-Morales, C. , Welsh, P. , Lyall, D. M. , Pell, J. P. , McInnes, I. B. , Siebert, S. and Sattar, N. (2019) Association of central adiposity with psoriasis, psoriatic arthritis and rheumatoid arthritis: a cross-sectional study of the UK Biobank. Rheumatology, (doi:10.1093/rheumatology/kez192) (PMID:31131407) (Early Online Publication)

Morris, J. et al. (2019) Genetic variation in CADM2 as a link between psychological traits and obesity. Scientific Reports, 9, 7339. (doi:10.1038/s41598-019-43861-9) (PMID:31089183) (PMCID:PMC6517397)

Sillars, A. et al. (2019) Association of fitness and grip-strength with heart failure: Findings from the UK Biobank population-based study. Mayo Clinic Proceedings, (Accepted for Publication)

Welsh, C. et al. (2019) Urinary sodium excretion, blood pressure and risk of future cardiovascular disease and mortality in subjects without prior cardiovascular disease. Hypertension, (doi:10.1161/HYPERTENSIONAHA.119.12726) (Early Online Publication)

Celis-Morales, C. A. et al. (2019) The combination of physical activity and sedentary behaviors modifies the genetic predisposition to obesity. Obesity, 27(4), pp. 653-661. (doi:10.1002/oby.22417) (PMID:30900409)

Lyall, D. M. et al. (2019) Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity. Brain Imaging and Behavior, (doi:10.1007/s11682-019-00069-9) (PMID:30903549) (Early Online Publication)

Celis-Morales, C. A. et al. (2019) Walking pace is associated with lower risk of all-cause and cause-specific mortality. Medicine and Science in Sports and Exercise, 51(3), pp. 472-480. (doi:10.1249/MSS.0000000000001795) (PMID:30303933)

Strawbridge, R. J. et al. (2019) Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide. EBioMedicine, 41, pp. 517-525. (doi:10.1016/j.ebiom.2019.02.005) (PMID:30745170) (PMCID:PMC6442001)

Celis-Morales, C.A. et al. (2018) Associations of dietary protein intake with fat free mass and grip strength: cross-sectional study in 146,816 UK Biobank participants. American Journal of Epidemiology, 187(11), pp. 2405-2414. (doi:10.1093/aje/kwy134) (PMID:29961893)

Wyse, C. A. et al. (2018) Population-level seasonality in cardiovascular mortality, blood pressure, BMI and inflammatory cells in UK Biobank. Annals of Medicine, 50(5), pp. 410-419. (doi:10.1080/07853890.2018.1472389) (PMID:29724143)

Mackay, A., Mackay, D.F. , Celis-Morales, C.A. , Lyall, D.M. , Gray, S.R. , Sattar, N. , Gill, J.M.R. , Pell, J.P. and Anderson, J.J. (2018) The association between driving time and unhealthy lifestyles: a cross-sectional, general population study of 386 493 UK Biobank participants. Journal of Public Health, (doi:10.1093/pubmed/fdy155) (PMID:30239914) (Early Online Publication)

Strawbridge, R. et al. (2018) Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. Translational Psychiatry, 8, 178. (doi:10.1038/s41398-018-0236-1) (PMID:30181555) (PMCID:PMC6123450)

Ferguson, A. et al. (2018) Genome-wide association study of circadian rhythmicity in 71,500 UK Biobank participants and polygenic association with mood instability. EBioMedicine, 35, pp. 279-287. (doi:10.1016/j.ebiom.2018.08.004) (PMID:30120083) (PMCID:PMC6154782)

Cullen, B. , Newby, D., Lee, D. , Lyall, D. M. , Nevado-Holgado, A. J., Evans, J. J. , Pell, J. P. , Lovestone, S. and Cavanagh, J. (2018) Cross-sectional and longitudinal analyses of outdoor air pollution exposure and cognitive function in UK Biobank. Scientific Reports, 8, 12089. (doi:10.1038/s41598-018-30568-6) (PMID:30108252) (PMCID:PMC6092329)

Lyall, L. M. et al. (2018) Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank. Lancet Psychiatry, 5(6), pp. 507-514. (doi:10.1016/S2215-0366(18)30139-1) (PMID:29776774)

Welsh, C. et al. (2018) Association of total and differential leukocyte counts with cardiovascular disease and mortality in the UK Biobank. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(6), pp. 1415-1423. (doi:10.1161/ATVBAHA.118.310945) (PMID:29699973)

Celis-Morales, C. et al. (2018) Associations of discretionary screen time with mortality, cardiovascular disease and cancer are attenuated by strength, fitness and physical activity: findings from the UK Biobank study. BMC Medicine, 16, 77. (doi:10.1186/s12916-018-1063-1) (PMID:29792209) (PMCID:PMC5966877)

Zhou, A. et al. (2018) Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants. Scientific Reports, 8, 7526. (doi:10.1038/s41598-018-25919-2) (PMID:29760501) (PMCID:PMC5951917)

Celis-Morales, C. A. et al. (2018) Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants. British Medical Journal, 361, k1651. (doi:10.1136/bmj.k1651) (PMID:29739772) (PMCID:PMC5939721)

Iliodromiti, S. et al. (2018) The impact of confounding on the associations of different adiposity measures with the incidence of cardiovascular disease: a cohort study of 296 535 adults of white European descent. European Heart Journal, 39(17), pp. 1514-1520. (doi:10.1093/eurheartj/ehy057) (PMID:29718151) (PMCID:PMC5930252)

Vaucher, J. et al. (2018) Cannabis use and risk of schizophrenia: a Mendelian randomization study. Molecular Psychiatry, 23(5), pp. 1287-1292. (doi:10.1038/mp.2016.252) (PMID:28115737) (PMCID:PMC5984096)

Lyall, L. M. et al. (2018) Seasonality of depressive symptoms in women but not in men: a cross-sectional study in the UK Biobank cohort. Journal of Affective Disorders, 229, pp. 296-305. (doi:10.1016/j.jad.2017.12.106) (PMID:29329063)

Strawbridge, R. J. et al. (2018) Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort. Translational Psychiatry, 8, 39. (doi:10.1038/s41398-017-0079-1) (PMID:29391395) (PMCID:PMC5804026)

Anderson, J. J. , Darwis, N. D.M., Mackay, D. F. , Celis-Morales, C. , Lyall, D. M. , Sattar, N. , Gill, J. M.R. and Pell, J. P. (2018) Red and processed meat consumption and breast cancer: UK Biobank cohort study and meta-analysis. European Journal of Cancer, 90, pp. 73-82. (doi:10.1016/j.ejca.2017.11.022)

Celis-Morales, C. A. et al. (2017) Associations between diabetes and both cardiovascular disease and all-cause mortality are modified by grip strength: evidence from UK Biobank, a prospective population-based cohort study. Diabetes Care, 40(12), pp. 1710-1718. (doi:10.2337/dc17-0921) (PMID:28986505)

Ward, J. et al. (2017) Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia. Translational Psychiatry, 7, 1264. (doi:10.1038/s41398-017-0012-7) (PMID:29187730) (PMCID:PMC5802589)

Howard, D. M. et al. (2017) Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank. Wellcome Open Research, 2, 61. (doi:10.12688/wellcomeopenres.12171.1) (PMID:28989979) (PMCID:PMC5605947)

Lyall, D. M. et al. (2017) Association of body mass index with cardiometabolic disease in the UK Biobank: a Mendelian randomization study. JAMA Cardiology, 2(8), pp. 882-889. (doi:10.1001/jamacardio.2016.5804) (PMID:28678979) (PMCID:PMC5710596)

Celis-Morales, C. A. et al. (2017) Association between active commuting and incident cardiovascular disease, cancer, and mortality: prospective cohort study. BMJ, 357, j1456. (doi:10.1136/bmj.j1456) (PMID:28424154)

Anderson, J.J. , Celis, C.A. , Mackay, D.F. , Iliodromiti, S., Lyall, D.M. , Sattar, N. , Gill, J.M.R. and Pell, J.P. (2017) Adiposity among 132 479 UK Biobank participants; contribution of sugar intake vs other macronutrients. International Journal of Epidemiology, 46(2), pp. 492-501. (doi:10.1093/ije/dyw173) (PMID:27407038) (PMCID:PMC5837311)

Celis-Morales, C. et al. (2017) Sleep characteristics modify the association between genetic predisposition to obesity and anthropometric measurements in 119,679 UK Biobank participants. American Journal of Clinical Nutrition, 105(4), pp. 980-990. (doi:10.3945/ajcn.116.147231)

Lyall, D. M. , Celis-Morales, C. A. , Anderson, J. , Gill, J. M.R. , Mackay, D. F. , McIntosh, A. M., Smith, D. J. , Deary, I. J., Sattar, N. and Pell, J. P. (2017) Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants. European Heart Journal, 38(8), pp. 577-583. (doi:10.1093/eurheartj/ehw528) (PMID:28363219)

Schmidt, A. F. et al. (2017) PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. Lancet Diabetes and Endocrinology, 5(2), pp. 97-105. (doi:10.1016/S2213-8587(16)30396-5) (PMID:27908689) (PMCID:PMC5266795)

Celis-Morales, C. A. , Lyall, D. M. , Anderson, J. , Iliodromiti, S., Fan, Y., Ntuk, U. E., Mackay, D. F. , Pell, J. P. , Sattar, N. and Gill, J. M.R. (2017) The association between physical activity and risk of mortality is modulated by grip strength and cardiorespiratory fitness: evidence from 498 135 UK-Biobank participants. European Heart Journal, 38(2), pp. 116-122. (doi:10.1093/eurheartj/ehw249) (PMID:28158566)

Celis-Morales, C. et al. (2017) Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants. International Journal of Obesity, 41, pp. 1761-1768. (doi:10.1038/ijo.2017.169) (PMID:28736445)

Lyall, D. M. et al. (2016) Body-mass index and cardiometabolic disease: a Mendelian randomisation study of UK Biobank Participants. Lancet, 388(S2), S9-S9. (doi:10.1016/S0140-6736(16)32245-0)

Lyall, D. M. et al. (2016) Alzheimer disease genetic risk factor APOE e4, and cognitive abilities in 111,739 UK Biobank participants. Age and Ageing, 45(4), pp. 511-517. (doi:10.1093/ageing/afw068) (PMID:27103599)

Davies, G. et al. (2016) Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151). Molecular Psychiatry, 21, pp. 758-767. (doi:10.1038/mp.2016.45)

Lyall, D. M. et al. (2016) Cognitive test scores in UK Biobank: data reduction in 480,416 participants and longitudinal stability in 20,346 participants. PLoS ONE, 11(4), e0154222. (doi:10.1371/journal.pone.0154222) (PMID:27110937) (PMCID:PMC4844168)

Lyall, D. , Mackay, D. , Pell, J. and Smith, D. (2016) Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort. BJPsych Open, 2(1), pp. 38-44. (doi:10.1192/bjpo.bp.115.002154) (PMID:27703752) (PMCID:PMC4995581)

Siebert, S. , Lyall, D. M. , Mackay, D. F. , Porter, D. and McInnes, I. B. (2016) Characteristics of rheumatoid arthritis and its association with major comorbid conditions: cross-sectional study of 502 649 UK Biobank participants. RMD Open, 2(1), e000267. (doi:10.1136/rmdopen-2016-000267) (PMID:27403335) (PMCID:PMC4932291)

Smith, D.J. et al. (2016) Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci. Molecular Psychiatry, 21(6), pp. 749-757. (doi:10.1038/mp.2016.49) (PMID:27067015)

Lyall, D. M. et al. (2015) APOE/TOMM40genetic loci, white matter hyperintensities, and cerebral microbleeds. International Journal of Stroke, 10(8), pp. 1297-1300. (doi:10.1111/ijs.12615) (PMID:26310205)

Nicholl, B. et al. (2015) Ethnic differences in the association between depression and chronic pain: cross sectional results from UK Biobank. BMC Family Practice, 16, 128. (doi:10.1186/s12875-015-0343-5) (PMID:26445480) (PMCID:PMC4596418)

Lyall, D. M. et al. (2014) Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936. Neurobiology of Aging, 35(6), 1513.e25-1513.e33. (doi:10.1016/j.neurobiolaging.2014.01.006)

Lyall, D.M. et al. (2014) Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity? Translational Psychiatry, 4(9), e449. (doi:10.1038/tp.2014.89)

Lyall, D. M. et al. (2013) Alzheimer’s disease susceptibility genes APOE and TOMM40, and hippocampal Volumes in the Lothian Birth Cohort 1936. PLoS ONE, 8(11), e80513. (doi:10.1371/journal.pone.0080513) (PMID:24260406) (PMCID:PMC3829876)

Lyall, D. M. et al. (2013) ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936. Behavior Genetics, 43(1), pp. 13-23. (doi:10.1007/s10519-012-9570-x)

This list was generated on Mon Oct 14 10:02:24 2019 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Investigating causal associations between cardiometabolic risk factors, and cognitive/brain health using Mendelian Randomization
    American Psychological Foundation
    2019 - 2019
     
  • Investigating causal associations between cardiometabolic risk factors, and cerebrovascular health in UK Biobank using Mendelian Randomization
    Neurosciences Foundation
    2018 - 2018
     
  • Do genetic risk scores improve the predictive power of known risk factors for cardiovascular diseases (CvD)? A precision medicine approach
    NHS Greater Glasgow and Clyde Endowment Funds
    2017 - 2017
     

Supervision

    Donald is happy to be contacted by potential PhD students, on topics including epidemiology, cognitive abilities (like memory), imaging, genetics, ageing or psychology/psychiatry. 

    Current PhD students

    Ms. Amy Ferguson, 2015-2019:  Identification of novel endophenotypes for bipolar disorder using genetic risk score analysis (MRC Doctoral Training Programme PhD Studentship; co-supervisor). 

    Ms. Rachana Tank, 2019-2022: Understanding associations between cardiometabolic and brain health using Mendelian randomization in UK Biobank (Baillie Gifford Doctoral Training Programme studentship; principal supervisor). 

    Mr. Mohammad Jareebi 2019-2022: Smoking, genetics and health in UK Biobank (principal supervisor). 

  • Tank, Rachana
    Understanding associations between cardiometabolic and brain health using Mendelian randomization in UK Biobank

Teaching

Masters in Public Health (MPH); BSc Psychological Medicine; Masters in Global Health (Online Distance Learning).