Dr Donald Lyall

Senior Lecturer (Public Health)

telephone: 0141 330 1918
email: Donald.Lyall@glasgow.ac.uk

Clarice Pears Building, Byers Road, G12 8TA

Biography

Hello, my name is Donald and I’m a Senior Lecturer in Population Brain Health.

My research aims to understand how genetics, lifestyle and environment influence population brain health. That means dementias like Alzheimer’s Disease, neurodegenerative conditions like motor neuron disease, and aspects of cognitive and brain health - things like memory, reaction time, and how your brain changes with age.

I sometimes do work on psychological traits too, like depression and anxiety, and I’m very interested in some of the biases around who participates in research in the first place – because that influences what we think we know about the brain. From 2019-2023 I was lead for Applied Models and Digital Health at the Alzheimer’s Research UK Deep Phenotyping network, and you can read about that here.

I’m a big believer in open, transparent science, so you can find my Open Science Framework page here, which includes things like preprints, analytic ‘coding’ scripts for past papers, and poster presentations I’ve brought to conferences. I enjoy talking to people about our research – here is a quick talk I gave at Bright Club (although beware the casual swearing at 7:50!).

If you’re interested in current topics in epidemiology, brain health or research methods, I sometimes share things on my Twitter account, here.

Background

BSc Psychology (2004-2008; University of Stirling)

MSc Human Cognitive Neuropsychology (2009; University of Edinburgh)

Assistant Clinical Psychologist (2010; NHS Greater Glasgow and Clyde)

PhD 'Genetic contributions to cognitive ageing and structural brain MRI phenotypes' (2010-2013; University of Edinburgh)

Postdoctoral research fellow (2013-2014; Johns Hopkins University/National Institute on Aging)

Research Associate (2014-2017; University of Glasgow)

Lecturer (2017 to date; University of Glasgow)

Honorary Research Fellow (2022 to date; University of Edinburgh)

Research interests

My research uses existing population health data to understand the brain. That means big cohorts like UK Biobank, Clinical Practice Research Datalink (CPRD) and Lothian Birth Cohort 1936.

We have used a lot of techniques including relatively 'simple' cross-sectional associations, testing how brain structure mediates cognitive health, genetics-based Mendelian randomization and gene-by-environment interactions.

Here you can see a little video where I talk about my research. Sometimes for a paper I will do a little 'five minute video' on what we did and found, like this.

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013

Number of items: 117.

2024

Kancheva, A. K. , Wardlaw, J. M., Lyall, D. M. and Quinn, T. J. (2024) Clinical phenotypes associated with cerebral small vessel disease: an overview of systematic reviews. Neurology, 102(8), (doi: 10.1212/WNL.0000000000209267) (PMID:38552192)

Beydoun, M. A. et al. (2024) Helicobacter pylori, persistent infection burden and structural brain imaging markers. Brain Communications, 6(2), fcae088. (doi: 10.1093/braincomms/fcae088) (PMID:38529358) (PMCID:PMC10961948)

2023

Russell, E.R., Spencer, S.J., Atherton, C.M., Lyall, D.M. , Mackay, D.F. , Stewart, K., MacLean, J.A., Pell, J.P. and Stewart, W. (2023) Increased risk of lower limb osteoarthritis among former professional soccer (football) players. Occupational Medicine, 73(9), pp. 547-553. (doi: 10.1093/occmed/kqad132) (PMID:38070190) (PMCID:PMC10824258)

Petermann-Rocha, F., Deo, S. , Lyall, D. , Orkaby, A. R., Quinn, T. J. , Sattar, N. , Celis-Morales, C. , Pell, J. P. and Ho, F. K. (2023) Association between the AHA Life's Essential 8 score and incident all-cause dementia: a prospective cohort study from UK Biobank. Current Problems in Cardiology, 48(11), 101934. (doi: 10.1016/j.cpcardiol.2023.101934) (PMID:37422047)

Ranglani, S., Ward, J. , Sattar, N. , Strawbridge, R. J. and Lyall, D. M. (2023) Testing for associations between HbA1c levels, polygenic risk and brain health in UK Biobank (N = 39 283). Diabetes, Obesity and Metabolism, 25(11), pp. 3136-3143. (doi: 10.1111/dom.15207) (PMID:37435691)

Stolicyn, A., Lyall, L. M., Lyall, D. , Høier, N., Adams, M. J., Shen, X., Cole, J. H., McIntosh, A. M., Whalley, H. C. and Smith, D. J. (2023) Comprehensive assessment of sleep duration, insomnia and brain structure within the UK Biobank cohort. SLEEP, (doi: 10.1093/sleep/zsad274) (PMID:37889226) (Early Online Publication)

Stewart, W. et al. (2023) Risk of chronic traumatic encephalopathy in rugby union is associated with length of playing career. Acta Neuropathologica, (doi: 10.1007/s00401-023-02644-3) (PMID:37872234) (Early Online Publication)

Forsyth, L., Aman, A., Cullen, B. , Graham, N., Lyall, D. M. , Lyall, L. M., Pell, J. P. , Ward, J. , Smith, D. J. and Strawbridge, R. J. (2023) Genetic architecture of DCC and influence on psychological, psychiatric and cardiometabolic traits in multiple ancestry groups in UK Biobank. Journal of Affective Disorders, 339, pp. 943-953. (doi: 10.1016/j.jad.2023.07.052) (PMID:37487843)

Ward, J. et al. (2023) Consistent effects of the genetics of happiness across the lifespan and ancestries in multiple cohorts. Scientific Reports, 13, 17262. (doi: 10.1038/s41598-023-43193-9) (PMID:37828061) (PMCID:PMC10570373)

Beydoun, M. A., Beydoun, H. A., Fanelli-Kuczmarski, M. T., Weiss, J., Georgescu, M. F., Meirelles, O., Lyall, D. , Evans, M. K. and Zonderman, A. B. (2023) Pathways explaining racial/ethnic and socio-economic disparities in dementia incidence: the UK Biobank Study. Aging, 15(18), pp. 9310-9340. (doi: 10.18632/aging.205058) (PMID:37751591) (PMCID:PMC10564412)

Watt, J. K., Dickie, D. A. , Lyall, D. , Ward, J. , Ho, F., Dawson, J. and Quinn, T. J. (2023) Normative values of the brain health index in UK biobank. Neuroimage: Reports, 3(3), 100176. (doi: 10.1016/j.ynirp.2023.100176)

Lyall, L. M., Sangha, N., Zhu, X., Lyall, D. M. , Ward, J. , Strawbridge, R. J. , Cullen, B. and Smith, D. J. (2023) Subjective and objective sleep and circadian parameters as predictors of depression-related outcomes: a machine learning approach in UK Biobank. Journal of Affective Disorders, 335, pp. 83-94. (doi: 10.1016/j.jad.2023.04.138) (PMID:37156273)

Lyall, D. M. et al. (2023) Artificial intelligence for dementia—applied models and digital health. Alzheimer's and Dementia, (doi: 10.1002/alz.13391) (PMID:37496259) (Early Online Publication)

Russell, E. R., Lyall, D. M. and Stewart, W. (2023) HEalth And Dementia outcomes following Traumatic Brain Injury (HEAD-TBI): protocol for a retrospective cohort study. BMJ Open, 13(7), e073726. (doi: 10.1136/bmjopen-2023-073726) (PMID:37491097) (PMCID:PMC10373748)

Ward, J. et al. (2023) Polygenic risk of major depressive disorder as a risk factor for venous thromboembolism. Blood Advances, (doi: 10.1182/bloodadvances.2023010562) (PMID:37399490) (In Press)

Cullen, B. et al. (2023) Cognitive function in people with familial risk of depression. JAMA Psychiatry, 80(6), pp. 610-620. (doi: 10.1001/jamapsychiatry.2023.0716) (PMID:37074691) (PMCID:PMC10116387)

Tai, X. Y., Torzillo, E., Lyall, D. M. , Manohar, S., Husain, M. and Sen, A. (2023) Association of dementia risk with focal epilepsy and modifiable cardiovascular risk factors. JAMA Neurology, 80(5), pp. 445-454. (doi: 10.1001/jamaneurol.2023.0339) (PMID:36972059) (PMCID:PMC10043806)

Wauye, V. M., Ho, F. K. and Lyall, D. M. (2023) Psychosocial predictors of COVID-19 infection in UK biobank (N = 104 201). Journal of Public Health, (doi: 10.1093/pubmed/fdad009) (PMID:37144429) (Early Online Publication)

Ranson, J. M. et al. (2023) Harnessing the potential of machine learning and artificial intelligence for dementia research. Brain Informatics, 10, 6. (doi: 10.1186/s40708-022-00183-3) (PMID:36829050) (PMCID:PMC9958222)

Ward, J. et al. (2023) Testing for association between exonic glucagon-like peptide 1 receptor mutation with physical and brain health traits in UK Biobank. Diabetes, Obesity and Metabolism, 25(2), pp. 623-627. (doi: 10.1111/dom.14879) (PMID:36181450)

2022

Aman, A., Slob, E. A.W., Ward, J. , Cullen, B. , Graham, N., Lyall, D. M. , Sattar, N. and Strawbridge, R. J. (2022) Investigating the potential impact of PCSK9-inhibitors on mood disorders using eQTL-based Mendelian randomization. PLoS ONE, 17(12), e0279381. (doi: 10.1371/journal.pone.0279381) (PMID:36580462) (PMCID:PMC9799310)

Hay, R., Cullen, B. , Graham, N., Lyall, D. M. , Aman, A., Pell, J. P. , Ward, J. , Smith, D. J. and Strawbridge, R. J. (2022) Genetic analysis of the PCSK9 locus in psychological, psychiatric, metabolic and cardiovascular traits in UK Biobank. European Journal of Human Genetics, 30(12), pp. 1380-1390. (doi: 10.1038/s41431-022-01107-9) (PMID:35501368) (PMCID:PMC9712543)

Russell, E. R., Mackay, D. F. , Lyall, D. , Stewart, K., MacLean, J. A., Robson, J., Pell, J. P. and Stewart, W. (2022) Neurodegenerative disease risk among former international rugby union players. Journal of Neurology, Neurosurgery and Psychiatry, 93(12), pp. 1262-1268. (doi: 10.1136/jnnp-2022-329675) (PMID:36195436)

Stanciu, I., Anderson, J. , Siebert, S. , Mackay, D. and Lyall, D. M. (2022) Associations of mental health, sleep and cognition characteristics with rheumatoid arthritis and rheumatoid factor in the UK Biobank. Scientific Reports, 12, 19844. (doi: 10.1038/s41598-022-22021-6) (PMID:36400784) (PMCID:PMC9674828)

Ranson, J. M. et al. (2022) The emerging role of AI in dementia research and healthcare. In: Chen, T., Carter, J., Mahmud, M. and Khuman, A. S. (eds.) Artificial Intelligence in Healthcare: Recent Applications and Developments. Series: Brain Informatics and Health. Springer, pp. 95-106. ISBN 9789811952715 (doi: 10.1007/978-981-19-5272-2_4)

Esteban-Cornejo, I. et al. (2022) Handgrip strength and all-cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study. Journal of Cachexia, Sarcopenia and Muscle, 13(3), pp. 1514-1525. (doi: 10.1002/jcsm.12857) (PMID:35445560) (PMCID:PMC9178163)

Tai, X. Y., Veldsman, M., Lyall, D. M. , Littlejohns, T. J., Langa, K. M., Husain, M., Ranson, J. and Llewellyn, D. J. (2022) Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study. Lancet Healthy Longevity, 3(6), e428-e436. (doi: 10.1016/S2666-7568(22)00117-9) (PMID:35711612) (PMCID:PMC9184258)

Newby, D., Winchester, L., Sproviero, W., Fernandes, M., Ghose, U., Lyall, D. , Launer, L. J. and Nevado‐Holgado, A. J. (2022) The relationship between isolated hypertension with brain volumes in UK Biobank. Brain and Behavior, 12(5), e2525. (doi: 10.1002/brb3.2525) (PMID:35362209) (PMCID:PMC9120723)

Tank, R., Ward, J. , Flegal, K. E. , Smith, D. J. , Bailey, M. E.S. , Cavanagh, J. and Lyall, D. M. (2022) Association between polygenic risk for Alzheimer’s disease, brain structure and cognitive abilities in UK Biobank. Neuropsychopharmacology, 47(2), pp. 564-569. (doi: 10.1038/s41386-021-01190-4) (PMID:34621014) (PMCID:PMC8674313)

Lyall, D. M. , Quinn, T. , Lyall, L. M., Ward, J. , Anderson, J. J. , Smith, D. J. , Stewart, W. , Strawbridge, R. J. , Bailey, M. E.S. and Cullen, B. (2022) Quantifying bias in psychological and physical health in the UK Biobank imaging sub-sample. Brain Communications, 4(3), fcac119. (doi: 10.1093/braincomms/fcac119) (PMID:35651593) (PMCID:PMC9150072)

2021

Petermann-Rocha, F. et al. (2021) Dose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank. BMC Medicine, 19, 305. (doi: 10.1186/s12916-021-02172-5)

Welsh, P. et al. (2021) Lipoprotein(a) and cardiovascular disease: prediction, attributable risk fraction and estimating benefits from novel interventions. European Journal of Preventive Cardiology, 28(18), pp. 1991-2000. (doi: 10.1093/eurjpc/zwaa063) (PMID:33624048)

Sullivan, M. K. et al. (2021) Multimorbidity and the risk of major adverse kidney events: findings from the UK Biobank cohort. Clinical Kidney Journal, 14(11), pp. 2409-2419. (doi: 10.1093/ckj/sfab079) (PMCID:PMC8573008)

Anderson, J. J. et al. (2021) Remote history of VTE is associated with severe COVID-19 in middle and older age: UK Biobank cohort study. Journal of Thrombosis and Haemostasis, 19(10), pp. 2533-2538. (doi: 10.1111/jth.15452) (PMID:34242477) (PMCID:PMC8420476)

Jani, B. D. et al. (2021) Family history of diabetes and risk of SARS-COV-2 in UK Biobank: a prospective cohort study. Endocrinology, Diabetes and Metabolism, 4(4), e00283. (doi: 10.1002/edm2.283) (PMID:34505416) (PMCID:PMC8420405)

Sewell, M. D.E. et al. (2021) Associations between major psychiatric disorder polygenic risk scores and blood-based markers in UK Biobank. Brain Behavior and Immunity, 97, pp. 32-41. (doi: 10.1016/j.bbi.2021.06.002) (PMID:34107350)

Zhu, X., Ward, J. , Cullen, B. , Lyall, D. M. , Strawbridge, R. J. , Smith, D. J. and Lyall, L. M. (2021) Polygenic risk for schizophrenia, brain structure and environmental risk in UK Biobank. Schizophrenia Bulletin Open, 2(1), sgab042. (doi: 10.1093/schizbullopen/sgab042)

Burt, O., Johnston, K. J.A., Graham, N., Cullen, B. , Lyall, D. M. , Lyall, L. M., Pell, J. P. , Ward, J. , Smith, D. J. and Strawbridge, R. J. (2021) Genetic variation in the ASTN2 locus in cardiovascular, metabolic and psychiatric traits: evidence for pleiotropy rather than shared biology. Genes, 12(8), 1194. (doi: 10.3390/genes12081194) (PMID:34440368) (PMCID:PMC8391428)

Tank, R., Ward, J. , Celis-Morales, C. , Smith, D. J. , Flegal, K. E. and Lyall, D. M. (2021) Testing for interactions between APOE and Klotho genotypes on cognitive, dementia, and brain imaging metrics in UK Biobank. Journal of Alzheimer's Disease, 83(1), pp. 51-55. (doi: 10.3233/JAD-210181) (PMID:34219715)

Zhu, X., Ward, J. , Cullen, B. , Lyall, D. M. , Strawbridge, R. J. , Lyall, L. M. and Smith, D. J. (2021) Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank. Translational Psychiatry, 11, 395. (doi: 10.1038/s41398-021-01522-4) (PMID:34282121) (PMCID:PMC8289859)

Shaw, R. , Cullen, B. , Graham, N., Lyall, D. , Mackay, D. , Okolie, C., Pearsall, R., Ward, J. , John, A. and Smith, D. (2021) Living alone, loneliness and lack of emotional support as predictors of suicide and self-harm: a nine-year follow up of the UK Biobank cohort. Journal of Affective Disorders, 279, pp. 316-323. (doi: 10.1016/j.jad.2020.10.026) (PMID:33096330)

Strawbridge, R. J. et al. (2021) The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals. Scientific Reports, 11, 632. (doi: 10.1038/s41598-020-79964-x) (PMID:33436761) (PMCID:PMC7804422)

Lyall, D. M. , Ward, J. , Banach, M., Smith, G. D., Gill, J. G. , Pell, J. P. , Holmes, M. V. and Sattar, N. (2021) PCSK9 genetic variants and cognitive abilities: a large-scale Mendelian randomization study. Archives of Medical Science, 17(1), pp. 241-244. (doi: 10.5114/aoms/127226)

Milton, D. C., Ward, J. , Ward, E., Lyall, D. M. , Strawbridge, R. J. , Smith, D. J. and Cullen, B. (2021) The association between C-reactive protein, mood disorder and cognitive function in UK Biobank European Psychiatry. European Psychiatry, 64(1), e14. (doi: 10.1192/j.eurpsy.2021.6) (PMID:33517931) (PMCID:PMC8057439)

2020

Ferguson, A. C. et al. (2020) Association of SBP and BMI with cognitive and structural brain phenotypes in UK Biobank. Journal of Hypertension, 38(12), pp. 2482-2489. (doi: 10.1097/HJH.0000000000002579) (PMID:32665523)

Morris, J. et al. (2020) Exploring the role of contactins across psychological, psychiatric and cardiometabolic traits within UK Biobank. Genes, 11(11), 1326. (doi: 10.3390/genes11111326) (PMID:33182605) (PMCID:PMC7697406)

Petermann-Rocha, F. et al. (2020) Comparison of two different frailty measurements and risk of hospitalisation or death from COVID-19: findings from UK Biobank. BMC Medicine, 18, 355. (doi: 10.1186/s12916-020-01822-4) (PMID:33167965) (PMCID:PMC7652674)

Ward, J. et al. (2020) The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. Molecular Psychiatry, 25(11), pp. 3091-3099. (doi: 10.1038/s41380-019-0439-8) (PMID:31168069) (PMCID:PMC7116257)

Lyall, D. M. et al. (2020) Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity. Brain Imaging and Behavior, 14(5), pp. 1468-1476. (doi: 10.1007/s11682-019-00069-9) (PMID:30903549) (PMCID:PMC7572345)

Ferguson, A. C. et al. (2020) Alzheimer’s disease susceptibility gene apolipoprotein e (APOE) and blood biomarkers in UK Biobank (N=395,769). Journal of Alzheimer's Disease, 76(4), pp. 1541-1551. (doi: 10.3233/JAD-200338) (PMID:32651323)

Coleman, J. R.I. et al. (2020) Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry, 25(7), pp. 1430-1446. (doi: 10.1038/s41380-019-0546-6) (PMID:31969693) (PMCID:PMC7305950)

Ho, F. K., Celis-Morales, C. , Gray, S. R. , Petermann-Rocha, F., Lyall, D. , Mackay, D. , Sattar, N. , Minnis, H. and Pell, J. P. (2020) Child maltreatment and cardiovascular disease: quantifying mediation pathways using UK Biobank. BMC Medicine, 18, 143. (doi: 10.1186/s12916-020-01603-z) (PMID:32527275) (PMCID:PMC7291652)

Welsh, C. E. et al. (2020) Grip strength and walking pace and cardiovascular disease risk prediction in 406,834 UK Biobank participants. Mayo Clinic Proceedings, 95(5), pp. 879-888. (doi: 10.1016/j.mayocp.2019.12.032) (PMID:32299669)

Hayes, S. et al. (2020) Association between walking pace and stroke incidence: findings from the UK Biobank prospective cohort study. Stroke, 51(5), pp. 1388-1395. (doi: 10.1161/STROKEAHA.119.028064) (PMID:32299326)

Anderson, J. J. , Gray, S. R. , Welsh, P. , Mackay, D. F. , Celis-Morales, C. A. , Lyall, D. M. , Forbes, J., Sattar, N. , Gill, J. M.R. and Pell, J. P. (2020) The associations of sugar-sweetened, artificially sweetened and naturally sweet juices with all-cause mortality in 198,285 UK Biobank participants: a prospective cohort study. BMC Medicine, 18(1), 97. (doi: 10.1186/s12916-020-01554-5) (PMID:32326961)

Welsh, C. et al. (2020) Association of injury related hospital admissions with commuting by bicycle in the UK: prospective population based study. British Medical Journal, 368, m336. (doi: 10.1136/bmj.m336) (PMID:32161038) (PMCID:PMC7190046)

Ho, F. K. et al. (2020) Associations of fat and carbohydrate intake with cardiovascular disease and mortality: prospective cohort study of UK Biobank participants. British Medical Journal, 368(8238), m688. (doi: 10.1136/bmj.m688) (PMID:32188587)

Strawbridge, R. J. et al. (2020) Carotid intima-media thickness: novel loci, sex-specific effects, and genetic correlations with obesity and glucometabolic traits in UK Biobank. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(2), pp. 446-461. (doi: 10.1161/ATVBAHA.119.313226) (PMID:31801372) (PMCID:PMC6975521)

Welsh, C. et al. (2020) Glycated hemoglobin, prediabetes and the links to cardiovascular disease: data from UK Biobank. Diabetes Care, 43(2), pp. 440-445. (doi: 10.2337/dc19-1683) (PMID:31852727)

2019

Ward, J. et al. (2019) Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure. Translational Psychiatry, 9, 327. (doi: 10.1038/s41398-019-0635-y) (PMID:31797917) (PMCID:PMC6892870)

Davies, M. R. et al. (2019) The Genetic Links to anxiety and depression (GLAD) study: online recruitment into the largest recontactable study of depression and anxiety. Behaviour Research and Therapy, 123, 103503. (doi: 10.1016/j.brat.2019.103503) (PMID:31715324) (PMCID:PMC6891252)

Ferguson, L. D. , Brown, R., Celis-Morales, C. , Welsh, P. , Lyall, D. M. , Pell, J. P. , McInnes, I. B. , Siebert, S. and Sattar, N. (2019) Association of central adiposity with psoriasis, psoriatic arthritis and rheumatoid arthritis: a cross-sectional study of the UK Biobank. Rheumatology, 58(12), pp. 2137-2142. (doi: 10.1093/rheumatology/kez192) (PMID:31131407) (PMCID:PMC6880847)

Lees, J. S. et al. (2019) Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease. Nature Medicine, 25, pp. 1753-1760. (doi: 10.1038/s41591-019-0627-8) (PMID:31700174) (PMCID:PMC6858876)

Sillars, A. et al. (2019) Association of fitness and grip-strength with heart failure: findings from the UK Biobank population-based study. Mayo Clinic Proceedings, 94(11), pp. 2230-2240. (doi: 10.1016/j.mayocp.2019.04.041) (PMID:31685151)

Steell, L. et al. (2019) Dose-response associations of cardiorespiratory fitness with all-cause mortality and incidence and mortality of cancer and cardiovascular and respiratory diseases: the UK Biobank cohort study. British Journal of Sports Medicine, 53(21), pp. 1371-1378. (doi: 10.1136/bjsports-2018-099093) (PMID:30796106)

Ho, F. K.W. et al. (2019) The association between handgrip strength and future health outcomes does not differ if grip strength is used in absolute or relative terms: a prospective cohort study. Age and Ageing, 48(5), pp. 683-691. (doi: 10.1093/ageing/afz068) (PMID:31204772)

Mackay, A., Mackay, D.F. , Celis-Morales, C.A. , Lyall, D.M. , Gray, S.R. , Sattar, N. , Gill, J.M.R. , Pell, J.P. and Anderson, J.J. (2019) The association between driving time and unhealthy lifestyles: a cross-sectional, general population study of 386 493 UK Biobank participants. Journal of Public Health, 41(3), pp. 527-534. (doi: 10.1093/pubmed/fdy155) (PMID:30239914)

Welsh, C. et al. (2019) Comparison of conventional lipoprotein tests and apolipoproteins in the prediction of cardiovascular disease: data from UK Biobank. Circulation, 140(7), pp. 542-552. (doi: 10.1161/CIRCULATIONAHA.119.041149) (PMID:31216866) (PMCID:PMC6693929)

Gray, S. et al. (2019) Do physical activity, commuting mode, cardiorespiratory fitness and sedentary behaviours modify the genetic predisposition to higher BMI? Findings from a UK Biobank study. International Journal of Obesity, 43, pp. 1526-1538. (doi: 10.1038/s41366-019-0381-5) (PMID:31168053)

Lyall, L. M., Cullen, B. , Lyall, D. M. , Leighton, S. P. , Siebert, S. , Smith, D. J. and Cavanagh, J. (2019) The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank. European Psychiatry, 60, pp. 63-70. (doi: 10.1016/j.eurpsy.2019.05.007) (PMID:31158611) (PMCID:PMC6669333)

Cox, S.R. et al. (2019) Associations between vascular risk factors and brain MRI indices in UK Biobank. European Heart Journal, 40(28), pp. 2290-2300. (doi: 10.1093/eurheartj/ehz100) (PMID:30854560) (PMCID:PMC6642726)

Lyall, D. M. et al. (2019) Assessing for interaction between APOE ε4, sex and lifestyle on cognitive abilities. Neurology, 92, e2691-e2698. (doi: 10.1212/WNL.0000000000007551) (PMID:31028125) (PMCID:PMC6556094)

Welsh, C. et al. (2019) Urinary sodium excretion, blood pressure and risk of future cardiovascular disease and mortality in subjects without prior cardiovascular disease. Hypertension, 73, pp. 1202-1209. (doi: 10.1161/HYPERTENSIONAHA.119.12726) (PMID:31067194)

Morris, J. et al. (2019) Genetic variation in CADM2 as a link between psychological traits and obesity. Scientific Reports, 9, 7339. (doi: 10.1038/s41598-019-43861-9) (PMID:31089183) (PMCID:PMC6517397)

Celis-Morales, C. A. et al. (2019) The combination of physical activity and sedentary behaviors modifies the genetic predisposition to obesity. Obesity, 27(4), pp. 653-661. (doi: 10.1002/oby.22417) (PMID:30900409)

Celis-Morales, C. A. et al. (2019) Walking pace is associated with lower risk of all-cause and cause-specific mortality. Medicine and Science in Sports and Exercise, 51(3), pp. 472-480. (doi: 10.1249/MSS.0000000000001795) (PMID:30303933)

Strawbridge, R. J. et al. (2019) Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide. EBioMedicine, 41, pp. 517-525. (doi: 10.1016/j.ebiom.2019.02.005) (PMID:30745170) (PMCID:PMC6442001)

Drozdowska, B. A. , Celis-Morales, C. A. , Lyall, D. M. and Quinn, T. J. (2019) Social engagement after stroke – is it relevant to cognitive function? A cross-sectional analysis of UK Biobank data. AMRC Open Research, 1, 3. (doi: 10.12688/amrcopenres.12862.2)

2018

Celis-Morales, C.A. et al. (2018) Associations of dietary protein intake with fat free mass and grip strength: cross-sectional study in 146,816 UK Biobank participants. American Journal of Epidemiology, 187(11), pp. 2405-2414. (doi: 10.1093/aje/kwy134) (PMID:29961893)

Wyse, C. A. et al. (2018) Population-level seasonality in cardiovascular mortality, blood pressure, BMI and inflammatory cells in UK Biobank. Annals of Medicine, 50(5), pp. 410-419. (doi: 10.1080/07853890.2018.1472389) (PMID:29724143)

Strawbridge, R. et al. (2018) Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. Translational Psychiatry, 8, 178. (doi: 10.1038/s41398-018-0236-1) (PMID:30181555) (PMCID:PMC6123450)

Ferguson, A. et al. (2018) Genome-wide association study of circadian rhythmicity in 71,500 UK Biobank participants and polygenic association with mood instability. EBioMedicine, 35, pp. 279-287. (doi: 10.1016/j.ebiom.2018.08.004) (PMID:30120083) (PMCID:PMC6154782)

Cullen, B. , Newby, D., Lee, D. , Lyall, D. M. , Nevado-Holgado, A. J., Evans, J. J. , Pell, J. P. , Lovestone, S. and Cavanagh, J. (2018) Cross-sectional and longitudinal analyses of outdoor air pollution exposure and cognitive function in UK Biobank. Scientific Reports, 8, 12089. (doi: 10.1038/s41598-018-30568-6) (PMID:30108252) (PMCID:PMC6092329)

Lyall, L. M. et al. (2018) Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank. Lancet Psychiatry, 5(6), pp. 507-514. (doi: 10.1016/S2215-0366(18)30139-1) (PMID:29776774)

Welsh, C. et al. (2018) Association of total and differential leukocyte counts with cardiovascular disease and mortality in the UK Biobank. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(6), pp. 1415-1423. (doi: 10.1161/ATVBAHA.118.310945) (PMID:29699973)

Celis-Morales, C. et al. (2018) Associations of discretionary screen time with mortality, cardiovascular disease and cancer are attenuated by strength, fitness and physical activity: findings from the UK Biobank study. BMC Medicine, 16, 77. (doi: 10.1186/s12916-018-1063-1) (PMID:29792209) (PMCID:PMC5966877)

Zhou, A. et al. (2018) Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants. Scientific Reports, 8, 7526. (doi: 10.1038/s41598-018-25919-2) (PMID:29760501) (PMCID:PMC5951917)

Celis-Morales, C. A. et al. (2018) Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants. British Medical Journal, 361, k1651. (doi: 10.1136/bmj.k1651) (PMID:29739772) (PMCID:PMC5939721)

Iliodromiti, S. et al. (2018) The impact of confounding on the associations of different adiposity measures with the incidence of cardiovascular disease: a cohort study of 296 535 adults of white European descent. European Heart Journal, 39(17), pp. 1514-1520. (doi: 10.1093/eurheartj/ehy057) (PMID:29718151) (PMCID:PMC5930252)

Vaucher, J. et al. (2018) Cannabis use and risk of schizophrenia: a Mendelian randomization study. Molecular Psychiatry, 23(5), pp. 1287-1292. (doi: 10.1038/mp.2016.252) (PMID:28115737) (PMCID:PMC5984096)

Lyall, L. M. et al. (2018) Seasonality of depressive symptoms in women but not in men: a cross-sectional study in the UK Biobank cohort. Journal of Affective Disorders, 229, pp. 296-305. (doi: 10.1016/j.jad.2017.12.106) (PMID:29329063)

Strawbridge, R. J. et al. (2018) Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort. Translational Psychiatry, 8, 39. (doi: 10.1038/s41398-017-0079-1) (PMID:29391395) (PMCID:PMC5804026)

Anderson, J. J. , Darwis, N. D.M., Mackay, D. F. , Celis-Morales, C. , Lyall, D. M. , Sattar, N. , Gill, J. M.R. and Pell, J. P. (2018) Red and processed meat consumption and breast cancer: UK Biobank cohort study and meta-analysis. European Journal of Cancer, 90, pp. 73-82. (doi: 10.1016/j.ejca.2017.11.022)

2017

Celis-Morales, C. A. et al. (2017) Associations between diabetes and both cardiovascular disease and all-cause mortality are modified by grip strength: evidence from UK Biobank, a prospective population-based cohort study. Diabetes Care, 40(12), pp. 1710-1718. (doi: 10.2337/dc17-0921) (PMID:28986505)

Ward, J. et al. (2017) Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia. Translational Psychiatry, 7, 1264. (doi: 10.1038/s41398-017-0012-7) (PMID:29187730) (PMCID:PMC5802589)

Howard, D. M. et al. (2017) Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank. Wellcome Open Research, 2, 61. (doi: 10.12688/wellcomeopenres.12171.1) (PMID:28989979) (PMCID:PMC5605947)

Lyall, D. M. et al. (2017) Association of body mass index with cardiometabolic disease in the UK Biobank: a Mendelian randomization study. JAMA Cardiology, 2(8), pp. 882-889. (doi: 10.1001/jamacardio.2016.5804) (PMID:28678979) (PMCID:PMC5710596)

Celis-Morales, C. A. et al. (2017) Association between active commuting and incident cardiovascular disease, cancer, and mortality: prospective cohort study. British Medical Journal, 357, j1456. (doi: 10.1136/bmj.j1456) (PMID:28424154)

Anderson, J.J. , Celis, C.A. , Mackay, D.F. , Iliodromiti, S., Lyall, D.M. , Sattar, N. , Gill, J.M.R. and Pell, J.P. (2017) Adiposity among 132 479 UK Biobank participants; contribution of sugar intake vs other macronutrients. International Journal of Epidemiology, 46(2), pp. 492-501. (doi: 10.1093/ije/dyw173) (PMID:27407038) (PMCID:PMC5837311)

Celis-Morales, C. et al. (2017) Sleep characteristics modify the association between genetic predisposition to obesity and anthropometric measurements in 119,679 UK Biobank participants. American Journal of Clinical Nutrition, 105(4), pp. 980-990. (doi: 10.3945/ajcn.116.147231)

Lyall, D. M. , Celis-Morales, C. A. , Anderson, J. , Gill, J. M.R. , Mackay, D. F. , McIntosh, A. M., Smith, D. J. , Deary, I. J., Sattar, N. and Pell, J. P. (2017) Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants. European Heart Journal, 38(8), pp. 577-583. (doi: 10.1093/eurheartj/ehw528) (PMID:28363219)

Schmidt, A. F. et al. (2017) PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. Lancet Diabetes and Endocrinology, 5(2), pp. 97-105. (doi: 10.1016/S2213-8587(16)30396-5) (PMID:27908689) (PMCID:PMC5266795)

Celis-Morales, C. A. , Lyall, D. M. , Anderson, J. , Iliodromiti, S., Fan, Y., Ntuk, U. E., Mackay, D. F. , Pell, J. P. , Sattar, N. and Gill, J. M.R. (2017) The association between physical activity and risk of mortality is modulated by grip strength and cardiorespiratory fitness: evidence from 498 135 UK-Biobank participants. European Heart Journal, 38(2), pp. 116-122. (doi: 10.1093/eurheartj/ehw249) (PMID:28158566) (PMCID:PMC5837781)

Celis-Morales, C. et al. (2017) Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants. International Journal of Obesity, 41, pp. 1761-1768. (doi: 10.1038/ijo.2017.169) (PMID:28736445)

2016

Lyall, D. M. et al. (2016) Body-mass index and cardiometabolic disease: a Mendelian randomisation study of UK Biobank Participants. Lancet, 388(S2), S9-S9. (doi: 10.1016/S0140-6736(16)32245-0)

Lyall, D. M. et al. (2016) Alzheimer disease genetic risk factor APOE e4, and cognitive abilities in 111,739 UK Biobank participants. Age and Ageing, 45(4), pp. 511-517. (doi: 10.1093/ageing/afw068) (PMID:27103599)

Davies, G. et al. (2016) Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151). Molecular Psychiatry, 21, pp. 758-767. (doi: 10.1038/mp.2016.45)

Lyall, D. M. et al. (2016) Cognitive test scores in UK Biobank: data reduction in 480,416 participants and longitudinal stability in 20,346 participants. PLoS ONE, 11(4), e0154222. (doi: 10.1371/journal.pone.0154222) (PMID:27110937) (PMCID:PMC4844168)

Lyall, D. , Mackay, D. , Pell, J. and Smith, D. (2016) Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort. BJPsych Open, 2(1), pp. 38-44. (doi: 10.1192/bjpo.bp.115.002154) (PMID:27703752) (PMCID:PMC4995581)

Siebert, S. , Lyall, D. M. , Mackay, D. F. , Porter, D. and McInnes, I. B. (2016) Characteristics of rheumatoid arthritis and its association with major comorbid conditions: cross-sectional study of 502 649 UK Biobank participants. RMD Open, 2(1), e000267. (doi: 10.1136/rmdopen-2016-000267) (PMID:27403335) (PMCID:PMC4932291)

Smith, D.J. et al. (2016) Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci. Molecular Psychiatry, 21(6), pp. 749-757. (doi: 10.1038/mp.2016.49) (PMID:27067015)

2015

Lyall, D. M. et al. (2015) APOE/TOMM40genetic loci, white matter hyperintensities, and cerebral microbleeds. International Journal of Stroke, 10(8), pp. 1297-1300. (doi: 10.1111/ijs.12615) (PMID:26310205)

Nicholl, B. et al. (2015) Ethnic differences in the association between depression and chronic pain: cross sectional results from UK Biobank. BMC Family Practice, 16, 128. (doi: 10.1186/s12875-015-0343-5) (PMID:26445480) (PMCID:PMC4596418)

2014

Lyall, D. M. et al. (2014) Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936. Neurobiology of Aging, 35(6), 1513.e25-1513.e33. (doi: 10.1016/j.neurobiolaging.2014.01.006)

Lyall, D.M. et al. (2014) Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity? Translational Psychiatry, 4(9), e449. (doi: 10.1038/tp.2014.89)

2013

Lyall, D. M. et al. (2013) Alzheimer’s disease susceptibility genes APOE and TOMM40, and hippocampal Volumes in the Lothian Birth Cohort 1936. PLoS ONE, 8(11), e80513. (doi: 10.1371/journal.pone.0080513) (PMID:24260406) (PMCID:PMC3829876)

Lyall, D. M. et al. (2013) ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936. Behavior Genetics, 43(1), pp. 13-23. (doi: 10.1007/s10519-012-9570-x)

This list was generated on Thu Apr 18 01:44:25 2024 BST.

Jump to: Articles | Book Sections

Number of items: 117.

Articles

Lyall, D. M. et al. (2023) Artificial intelligence for dementia—applied models and digital health. Alzheimer's and Dementia, (doi: 10.1002/alz.13391) (PMID:37496259) (Early Online Publication)

Ward, J. et al. (2023) Polygenic risk of major depressive disorder as a risk factor for venous thromboembolism. Blood Advances, (doi: 10.1182/bloodadvances.2023010562) (PMID:37399490) (In Press)

Welsh, C. et al. (2020) Glycated hemoglobin, prediabetes and the links to cardiovascular disease: data from UK Biobank. Diabetes Care, 43(2), pp. 440-445. (doi: 10.2337/dc19-1683) (PMID:31852727)

Lyall, D. M. et al. (2016) Body-mass index and cardiometabolic disease: a Mendelian randomisation study of UK Biobank Participants. Lancet, 388(S2), S9-S9. (doi: 10.1016/S0140-6736(16)32245-0)

Davies, G. et al. (2016) Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151). Molecular Psychiatry, 21, pp. 758-767. (doi: 10.1038/mp.2016.45)

Lyall, D. M. et al. (2013) ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936. Behavior Genetics, 43(1), pp. 13-23. (doi: 10.1007/s10519-012-9570-x)

Book Sections

This list was generated on Thu Apr 18 01:44:25 2024 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

UK TBI REpository and data PORTal Enabling discoveRy
Medical Research Council
2023 - 2028
Traumatic brain injury and motor neuron disease
MND Scotland
2023 - 2024
Healthcare matters: capturing the complexity of Primary Health Care for people with intellectual disabilities through record linkage and the Delphi method.
Baily Thomas Charitable Fund
2022 - 2023
Investigating causal associations between cardiometabolic risk factors, and cognitive/brain health using Mendelian Randomization
American Psychological Foundation
2019 - 2019
Investigating causal associations between cardiometabolic risk factors, and cerebrovascular health in UK Biobank using Mendelian Randomization
Neurosciences Foundation
2018 - 2018
Do genetic risk scores improve the predictive power of known risk factors for cardiovascular diseases (CvD)? A precision medicine approach
NHS Greater Glasgow and Clyde Endowment Funds
2017 - 2017

Supervision

I am very happy to be contacted by potential PhD students, on topics including epidemiology, cognitive abilities (like memory), imaging, genetics, ageing or psychology/psychiatry.

Current PhD students

Mr. Ahmed Althari: Cardiometabolic health and the brain (2021-2024)

Ms. Angelina Kancheva: Cerebrovascular disease (2022-2025)

Ms. Mengrong Zhang: Genetic contributions to cardiometabolic health (2022-2025)

Alharthi, Ahmed Abdulrahman S
Repurposing cardiovascular medicines for vascular dementia a data driven clinical study
Kancheva, Angelina Kirilova
Terry.Quinn@glasgow.ac.uk
You, Yating
The role of modifiable lifestyle factors in dementia

Completed PhD students

Dr. Amy Ferguson, 2015-2019: Identification of novel endophenotypes for bipolar disorder using genetic risk score analysis (MRC Doctoral Training Programme PhD Studentship; co-supervisor).

Dr. Rachana Tank, 2018-2021: Understanding associations between cardiometabolic and brain health using Mendelian randomization in UK Biobank (Baillie Gifford Doctoral Training Programme studentship; principal supervisor).

Dr. Mohammad Jareebi 2019-2023: Smoking, genetics and health in UK Biobank (Saudi Arabian funding; principal supervisor).

Dr. Ioana Stanciu 2019-2023: Genetic Epidemiology of Rheumatoid Arthritis in UK Biobank (MVLS DTP; principal supervisor)

Here you can see a little video of Rachana talking about her experience of a PhD here with us.

Teaching

Masters in Public Health (MPH); BSc Psychological Medicine; Masters in Global Health (Online Distance Learning).

Research datasets

Jump to: 2020 | 2019

Number of items: 6.

2020

Ward, J., Strawbridge, R. , Bailey, M. , Graham, N., Ferguson, A., Lyall, D. , Cullen, B. , Pidgeon, L., Cavanagh, J., Mackay, D. , Pell, J. , O'Donovan, M., Escott-Price, V. and Smith, D. (2020) Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia. [Data Collection]

2019

Strawbridge, R. , Ward, J., Ferguson, A., Graham, N., Shaw, R. , Cullen, B. , Pearsall, R., Lyall, L., Johnston, K., Niedzwiedz, C. , Pell, J. , Mackay, D. , Martin, J., Lyall, D. , Bailey, M. and Smith, D. (2019) Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide. [Data Collection]

Ferguson, A., Lyall, L., Ward, J., Strawbridge, R. , Cullen, B. , Graham, N., Niedzwiedz, C. , Johnston, K., Mackay, D. , Biello, S. , Pell, J. , Cavanagh, J., McIntosh, A. M., Doherty, A., Bailey, M. , Lyall, D. , Wyse, C. and Smith, D. (2019) Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability. [Data Collection]

Strawbridge, R. , Ward, J., Lyall, L., Tunbridge, E. M., Cullen, B. , Graham, N., Ferguson, A., Johnston, K., Lyall, D. , Mackay, D. , Cavanagh, J., Howard, D. M., Adams, M. J., Deary, I., Escott-Price, V., O’Donovan, M., McIntosh, A. M., Bailey, M. , Pell, J. , Harrison, P. and Smith, D. (2019) Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. [Data Collection]

Ward, J., Lyall, L., Bethlehem, R. A. I., Ferguson, A., Strawbridge, R. , Lyall, D. , Cullen, B. , Graham, N., Johnston, K., Bailey, M. , Murray, G. K. and Smith, D. (2019) Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure. [Data Collection]

Ward, J., Tunbridge, E. M., Sandor, C., Lyall, L., Ferguson, A., Strawbridge, R. , Lyall, D. , Cullen, B. , Graham, N., Johnston, K. J.A., Webber, C., Escott-Price, V., O’Donovan, M., Pell, J. , Bailey, M. , Harrison, P. J. and Smith, D. (2019) The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. [Data Collection]

This list was generated on Thu Apr 18 10:08:26 2024 BST.

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Hotjar and Clarity

Dr Donald Lyall

Biography

Research interests

Publications

2024

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

Articles

Book Sections

Grants

Supervision

Teaching

Research datasets

2020

2019