Dr Marc Ciosi

  • Research Associate (Institute of Molecular Cell & Systems Biology)

telephone: +44(0)1413306220
email: Marc.Ciosi@glasgow.ac.uk

Institute of MC & SB, Davidson building, Lab 412, Glasgow, G12 8qq

ORCID iDhttps://orcid.org/0000-0002-7663-4080

Biography

2014 - present

Postdoctoral research associate (University of Glasgow, UK). High throughput sequencing and genotype-phenotype approaches to study the HTT CAG/CCG repeat and its somatic instability in Huntington disease.

2011 - 2014

Postdoctoral research associate (University of Glasgow, UK / ICIPE, Kenya). Population genetics and co-adaptation of trypanosomes with tsetse flies.

2009 - 2010

Research and teaching assistant (INRA / University of Nice, France). Research activity: molecular ecology of invasive species. Teaching activity: Population genetics, molecular evolution and phylogeny, analysis of DNA sequence polymorphism, supervision of master students

2006 - 2009 Ph.D. thesis: Invasion of Europe by the western corn rootworm, Diabrotica virgifera virgifera.
2005

Master’s thesis: Physiology and symbiont diversity associated with depth in Eunicella singularis, symbiotic sea fan of the Mediterranean Sea.

 

Research interests

General interests:

- Genetic variation

- The processes that modify and generate genetic variation (within individuals and populations as well as between populations)

- The phenotypic and evolutionnary consequences of genetic variation

 

Particular interests:

- Genotype-phenotype association

- Impact of demography on genetic variation within populations

- Technologies used to type genetic variants

Publications

List by: Type | Date

Jump to: 2020 | 2019 | 2018 | 2017 | 2016 | 2014 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007
Number of items: 23.

2020

Ellis, N. et al. (2020) Genetic risk underlying psychiatric and cognitive symptoms in Huntington’s Disease. Biological Psychiatry, 87(9), pp. 857-865. (doi: 10.1016/j.biopsych.2019.12.010) (PMID:32087949)

2019

Ciosi, M. et al. (2019) A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes. EBioMedicine, 48, pp. 568-580. (doi: 10.1016/j.ebiom.2019.09.020) (PMID:31607598) (PMCID:PMC6838430)

Lee, J.-M. et al. (2019) CAG repeat not polyglutamine length determines timing of Huntington’s disease onset. Cell, 178(4), 887-900.e14. (doi: 10.1016/j.cell.2019.06.036)

Flower, M. et al. (2019) MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1. Brain, 142(7), pp. 1876-1886. (doi: 10.1093/brain/awz115) (PMID:31216018) (PMCID:PMC6598626)

2018

Channumsin, M., Ciosi, M. , Masiga, D., Turner, C. M. R. and Mable, B. K. (2018) Sodalis glossinidius presence in wild tsetse is only associated with presence of trypanosomes in complex interactions with other tsetse-specific factors. BMC Microbiology, 18(Supp1.), 163. (doi: 10.1186/s12866-018-1285-6) (PMID:30470184) (PMCID:PMC6251152)

Ciosi, M. et al. (2018) Glutamine Codon Usage and Somatic Mosaicism of the HTT CAG Repeat Are Modifiers of Huntington Disease Severity. EHDN 2018 Plenary Meeting, Vienna, Austria, 14-16 Sep 2018.

Flower, M., Lomeikaite, V., Ciosi, M. , Morales, F., Lo, K., Hensman Moss, D., Jones, L., Holmans, P., Tabrizi, S. J. and Monckton, D. G. (2018) Genetic Variation in MSH3 That Lowers Its Expression Ameliorates Disease Course and Limits Repeat Expansion in Huntington’s Disease and Myotonic Dystrophy Type 1. EHDN 2018 Plenary Meeting, Vienna, Austria, 14-16 Sep 2018.

Ging, H., Nethisinghe, S., Chatzi, A., Ciosi, M. , Monckton, D. G. and Giunti, P. (2018) Determining the CAG Repeat Mosaic in Post-mortem Human HD Brains. EHDN 2018 Plenary Meeting, Vienna, Austria, 14-16 Sep 2018.

Levesley, J., Baine, F., Ciosi, M. , Maxwell, A. , Monckton, D. G. and Krause, A. (2018) A CIS-acting Modifier of Age at Diagnosis of Huntington Disease in Black South African Patients. EHDN 2018 Plenary Meeting, Vienna, Austria, 14-16 Sep 2018.

Mugasa, C. M., Villinger, J., Gitau, J., Ndungu, N., Ciosi, M. and Masiga, D. (2018) Morphological re-description and molecular identification of Tabanidae (Diptera) in East Africa. ZooKeys, 796, pp. 117-144. (doi: 10.3897/zookeys.769.21144) (PMID:29988760) (PMCID:PMC6030178)

Lombaert, E., Ciosi, M. , Miller, N. J., Sappington, T. W., Blin, A. and Guillemaud, T. (2018) Colonization history of the western corn rootworm (Diabrotica virgifera virgifera) in North America: insights from random forest ABC using microsatellite data. Biological Invasions, 20(3), pp. 665-677. (doi: 10.1007/s10530-017-1566-2)

2017

Ndungu, N. N., Kiatoko, N., Ciosi, M. , Salifu, D., Nyansera, D., Masiga, D. and Raina, S. K. (2017) Identification of stingless bees (Hymenoptera: Apidae) in Kenya using Morphometrics and DNA barcoding. Journal of Apicultural Research, 56(4), pp. 341-353. (doi: 10.1080/00218839.2017.1327939)

2016

Monckton, D. , Ciosi, M. , Mubarak, A., Cumming, S., Hamilton, G., Maxwell, A. , The International-Venezuela Collaborative Research Group, -, The Scottish Myotonic Dystrophy Genetic Variation Consortium, - and The Track-On HD Research Team, - (2016) Cryptic Polyglutamine Repeat Sequence Variation and Somatic Instability in Huntington’s Disease: Drivers of Pathology? European Huntington's Disease Network 9th Plenary Meeting, The Hague, The Netherlands, 16-18 Sep 2016. (doi:10.1136/jnnp-2016-314597.2)

Isaac, C., Ciosi, M. , Hamilton, A., Scullion, K. M., Dede, P., Igbinosa, I. B., Nmorsi, O. P. G., Masiga, D. and Turner, C. M. R. (2016) Molecular identification of different trypanosome species and subspecies in tsetse flies of northern Nigeria. Parasites and Vectors, 9, 301. (doi: 10.1186/s13071-016-1585-3) (PMID:27216812) (PMCID:PMC4877947)

2014

Ciosi, M. , Masiga, D. K. and Turner, C. M.R. (2014) Laboratory colonisation and genetic bottlenecks in the tsetse fly Glossina pallidipes. PLoS Neglected Tropical Diseases, 8(2), e2697. (doi: 10.1371/journal.pntd.0002697)

2012

Bermond, G., Ciosi, M. , Lombaert, E., Blin, A., Boriani, M., Furlan, L., Toepfer, S. and Guillemaud, T. (2012) Secondary contact and admixture between independently invading populations of the Western corn rootworm, diabrotica virgifera virgifera in Europe. PLoS ONE, 7(11), e50129. (doi: 10.1371/journal.pone.0050129)

2011

Guillemaud, T., Ciosi, M. , Lombaert, E. and Estoup, A. (2011) Biological invasions in agricultural settings: insights from evolutionary biology and population genetics. Comptes Rendus Biologies, 334(3), pp. 237-246. (doi: 10.1016/j.crvi.2010.12.008)

Ciosi, M. , Miller, N.J., Toepfer, S., Estoup, A. and Guillemaud, T. (2011) Stratified dispersal and increasing genetic variation during the invasion of Central Europe by the western corn rootworm, Diabrotica virgifera virgifera. Evolutionary Applications, 4(1), pp. 57-70. (doi: 10.1111/j.1752-4571.2010.00133.x)

Forcioli, D., Merle, P.L., Caligara, C., Ciosi, M. , Muti, C., Francour, P., Cerrano, C. and Allemand, D. (2011) Symbiont diversity is not involved in depth acclimation in the Mediterranean sea whip Eunicella singularis. Marine Ecology Progress Series, 439, pp. 57-71. (doi: 10.3354/meps09314)

2010

Guillemaud, T., Beaumont, M.A., Ciosi, M. , Cornuet, J.-M. and Estoup, A. (2010) Inferring introduction routes of invasive species using approximate Bayesian computation on microsatellite data. Heredity, 104(1), pp. 88-99. (doi: 10.1038/hdy.2009.92)

2009

Ciosi, M. , Toepfer, S., Li, H., Haye, T., Kuhlmann, U., Wang, H., Siegfried, B. and Guillemaud, T. (2009) European populations of Diabrotica virgifera virgifera are resistant to aldrin, but not to methyl-parathion. Journal of Applied Entomology, 133(4), pp. 307-314. (doi: 10.1111/j.1439-0418.2008.01363.x)

2008

Ciosi, M. , Miller, N.J., Kim, K.S., Giordano, R., Estoup, A. and Guillemaud, T. (2008) Invasion of Europe by the western corn rootworm, Diabrotica virgifera virgifera: multiple transatlantic introductions with various reductions of genetic diversity. Molecular Ecology, 17(16), pp. 3614-3627. (doi: 10.1111/j.1365-294X.2008.03866.x)

2007

Miller, N.J., Ciosi, M. , Sappington, T.W., Ratcliffe, S.T., Spencer, J.L. and Guillemaud, T. (2007) Genome scan of Diabrotica virgifera virgifera for genetic variation associated with crop rotation tolerance. Journal of Applied Entomology, 131(6), pp. 378-385. (doi: 10.1111/j.1439-0418.2007.01190.x)

This list was generated on Wed Aug 5 01:25:39 2020 BST.
Number of items: 23.

Articles

Ellis, N. et al. (2020) Genetic risk underlying psychiatric and cognitive symptoms in Huntington’s Disease. Biological Psychiatry, 87(9), pp. 857-865. (doi: 10.1016/j.biopsych.2019.12.010) (PMID:32087949)

Ciosi, M. et al. (2019) A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes. EBioMedicine, 48, pp. 568-580. (doi: 10.1016/j.ebiom.2019.09.020) (PMID:31607598) (PMCID:PMC6838430)

Lee, J.-M. et al. (2019) CAG repeat not polyglutamine length determines timing of Huntington’s disease onset. Cell, 178(4), 887-900.e14. (doi: 10.1016/j.cell.2019.06.036)

Flower, M. et al. (2019) MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1. Brain, 142(7), pp. 1876-1886. (doi: 10.1093/brain/awz115) (PMID:31216018) (PMCID:PMC6598626)

Channumsin, M., Ciosi, M. , Masiga, D., Turner, C. M. R. and Mable, B. K. (2018) Sodalis glossinidius presence in wild tsetse is only associated with presence of trypanosomes in complex interactions with other tsetse-specific factors. BMC Microbiology, 18(Supp1.), 163. (doi: 10.1186/s12866-018-1285-6) (PMID:30470184) (PMCID:PMC6251152)

Mugasa, C. M., Villinger, J., Gitau, J., Ndungu, N., Ciosi, M. and Masiga, D. (2018) Morphological re-description and molecular identification of Tabanidae (Diptera) in East Africa. ZooKeys, 796, pp. 117-144. (doi: 10.3897/zookeys.769.21144) (PMID:29988760) (PMCID:PMC6030178)

Lombaert, E., Ciosi, M. , Miller, N. J., Sappington, T. W., Blin, A. and Guillemaud, T. (2018) Colonization history of the western corn rootworm (Diabrotica virgifera virgifera) in North America: insights from random forest ABC using microsatellite data. Biological Invasions, 20(3), pp. 665-677. (doi: 10.1007/s10530-017-1566-2)

Ndungu, N. N., Kiatoko, N., Ciosi, M. , Salifu, D., Nyansera, D., Masiga, D. and Raina, S. K. (2017) Identification of stingless bees (Hymenoptera: Apidae) in Kenya using Morphometrics and DNA barcoding. Journal of Apicultural Research, 56(4), pp. 341-353. (doi: 10.1080/00218839.2017.1327939)

Isaac, C., Ciosi, M. , Hamilton, A., Scullion, K. M., Dede, P., Igbinosa, I. B., Nmorsi, O. P. G., Masiga, D. and Turner, C. M. R. (2016) Molecular identification of different trypanosome species and subspecies in tsetse flies of northern Nigeria. Parasites and Vectors, 9, 301. (doi: 10.1186/s13071-016-1585-3) (PMID:27216812) (PMCID:PMC4877947)

Ciosi, M. , Masiga, D. K. and Turner, C. M.R. (2014) Laboratory colonisation and genetic bottlenecks in the tsetse fly Glossina pallidipes. PLoS Neglected Tropical Diseases, 8(2), e2697. (doi: 10.1371/journal.pntd.0002697)

Bermond, G., Ciosi, M. , Lombaert, E., Blin, A., Boriani, M., Furlan, L., Toepfer, S. and Guillemaud, T. (2012) Secondary contact and admixture between independently invading populations of the Western corn rootworm, diabrotica virgifera virgifera in Europe. PLoS ONE, 7(11), e50129. (doi: 10.1371/journal.pone.0050129)

Guillemaud, T., Ciosi, M. , Lombaert, E. and Estoup, A. (2011) Biological invasions in agricultural settings: insights from evolutionary biology and population genetics. Comptes Rendus Biologies, 334(3), pp. 237-246. (doi: 10.1016/j.crvi.2010.12.008)

Ciosi, M. , Miller, N.J., Toepfer, S., Estoup, A. and Guillemaud, T. (2011) Stratified dispersal and increasing genetic variation during the invasion of Central Europe by the western corn rootworm, Diabrotica virgifera virgifera. Evolutionary Applications, 4(1), pp. 57-70. (doi: 10.1111/j.1752-4571.2010.00133.x)

Forcioli, D., Merle, P.L., Caligara, C., Ciosi, M. , Muti, C., Francour, P., Cerrano, C. and Allemand, D. (2011) Symbiont diversity is not involved in depth acclimation in the Mediterranean sea whip Eunicella singularis. Marine Ecology Progress Series, 439, pp. 57-71. (doi: 10.3354/meps09314)

Guillemaud, T., Beaumont, M.A., Ciosi, M. , Cornuet, J.-M. and Estoup, A. (2010) Inferring introduction routes of invasive species using approximate Bayesian computation on microsatellite data. Heredity, 104(1), pp. 88-99. (doi: 10.1038/hdy.2009.92)

Ciosi, M. , Toepfer, S., Li, H., Haye, T., Kuhlmann, U., Wang, H., Siegfried, B. and Guillemaud, T. (2009) European populations of Diabrotica virgifera virgifera are resistant to aldrin, but not to methyl-parathion. Journal of Applied Entomology, 133(4), pp. 307-314. (doi: 10.1111/j.1439-0418.2008.01363.x)

Ciosi, M. , Miller, N.J., Kim, K.S., Giordano, R., Estoup, A. and Guillemaud, T. (2008) Invasion of Europe by the western corn rootworm, Diabrotica virgifera virgifera: multiple transatlantic introductions with various reductions of genetic diversity. Molecular Ecology, 17(16), pp. 3614-3627. (doi: 10.1111/j.1365-294X.2008.03866.x)

Miller, N.J., Ciosi, M. , Sappington, T.W., Ratcliffe, S.T., Spencer, J.L. and Guillemaud, T. (2007) Genome scan of Diabrotica virgifera virgifera for genetic variation associated with crop rotation tolerance. Journal of Applied Entomology, 131(6), pp. 378-385. (doi: 10.1111/j.1439-0418.2007.01190.x)

Conference or Workshop Item

Ciosi, M. et al. (2018) Glutamine Codon Usage and Somatic Mosaicism of the HTT CAG Repeat Are Modifiers of Huntington Disease Severity. EHDN 2018 Plenary Meeting, Vienna, Austria, 14-16 Sep 2018.

Flower, M., Lomeikaite, V., Ciosi, M. , Morales, F., Lo, K., Hensman Moss, D., Jones, L., Holmans, P., Tabrizi, S. J. and Monckton, D. G. (2018) Genetic Variation in MSH3 That Lowers Its Expression Ameliorates Disease Course and Limits Repeat Expansion in Huntington’s Disease and Myotonic Dystrophy Type 1. EHDN 2018 Plenary Meeting, Vienna, Austria, 14-16 Sep 2018.

Ging, H., Nethisinghe, S., Chatzi, A., Ciosi, M. , Monckton, D. G. and Giunti, P. (2018) Determining the CAG Repeat Mosaic in Post-mortem Human HD Brains. EHDN 2018 Plenary Meeting, Vienna, Austria, 14-16 Sep 2018.

Levesley, J., Baine, F., Ciosi, M. , Maxwell, A. , Monckton, D. G. and Krause, A. (2018) A CIS-acting Modifier of Age at Diagnosis of Huntington Disease in Black South African Patients. EHDN 2018 Plenary Meeting, Vienna, Austria, 14-16 Sep 2018.

Monckton, D. , Ciosi, M. , Mubarak, A., Cumming, S., Hamilton, G., Maxwell, A. , The International-Venezuela Collaborative Research Group, -, The Scottish Myotonic Dystrophy Genetic Variation Consortium, - and The Track-On HD Research Team, - (2016) Cryptic Polyglutamine Repeat Sequence Variation and Somatic Instability in Huntington’s Disease: Drivers of Pathology? European Huntington's Disease Network 9th Plenary Meeting, The Hague, The Netherlands, 16-18 Sep 2016. (doi:10.1136/jnnp-2016-314597.2)

This list was generated on Wed Aug 5 01:25:39 2020 BST.

Teaching

Hands-on tutorial on the Galaxy web-based platform: Microsatellite genotyping from parallel sequencing reads spanning the repeat

21 and 23/11/2016 6 hours

25/07/2016 5 hours