Dr Victoria Gillan
- Research Fellow (Institute of Biodiversity Animal Health & Comparative Medicine)
- Associate (School of Veterinary Medicine)
email:
Victoria.Gillan@glasgow.ac.uk
210D, Urquhart Building, Garscube, Glasgow G61 1BD
https://orcid.org/0000-0002-5728-1275Research interests
My work is focussed on the biology of nematode and apicomplexan infections, specifically in neglected tropical disease. My interests are two-fold: the role of miRNA in the regulation of parasite gene expression and Hsp90 as a molecular target in parasites
Publications
2019
Gillan, V. , Simpson, D. M., Kinnaird, J., Maitland, K. , Shiels, B. and Devaney, E. (2019) Characterisation of infection associated microRNA and protein cargo in extracellular vesicles of Theileria annulata infected leukocytes. Cellular Microbiology, 21, e12969. (doi: 10.1111/cmi.12969) (PMID:30370674) (PMCID:PMC6492283)
Marks, N. D. et al. (2019) Profiling microRNAs through development of the parasitic nematode Haemonchus identifies nematode-specific miRNAs that suppress larval development. Scientific Reports, 9, 17594. (doi: 10.1038/s41598-019-54154-6) (PMID:31772378) (PMCID:PMC6879476)
2017
Gillan, V. et al. (2017) Increased expression of a microRNA correlates with anthelmintic resistance in parasitic nematodes. Frontiers in Cellular and Infection Microbiology, 7, 452. (doi: 10.3389/fcimb.2017.00452) (PMID:29209592) (PMCID:PMC5701612)
Laing, R. , Gillan, V. and Devaney, E. (2017) Ivermectin - old drug, new tricks? Trends in Parasitology, 33(6), pp. 463-472. (doi: 10.1016/j.pt.2017.02.004) (PMID:28285851) (PMCID:PMC5446326)
Kinnaird, J. H., Singh, M., Gillan, V. , Weir, W. , Calder, E. D.D., Hostettler, I., Tatu, U., Devaney, E. and Shiels, B. R. (2017) Characterization of HSP90 isoforms in transformed bovine leukocytes infected with Theileria annulata. Cellular Microbiology, 19(3), e12669. (doi: 10.1111/cmi.12669) (PMID:27649068) (PMCID:PMC5333456)
2016
Devaney, E. and Gillan, V. (2016) Hsp90 inhibitors in parasitic nematodes: prospects and challenges. Current Topics in Medicinal Chemistry, 16(25), pp. 2805-2811. (doi: 10.2174/1568026616666160413140502) (PMID:27072703)
2015
Britton, C. , Winter, A. D., Marks, N. D., Gu, H., McNeilly, T. N., Gillan, V. and Devaney, E. (2015) Application of small RNA technology for improved control of parasitic helminths. Veterinary Parasitology, 212(1-2), pp. 47-53. (doi: 10.1016/j.vetpar.2015.06.003) (PMID:26095949) (PMCID:PMC4535316)
Winter, A. D. et al. (2015) A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites. BMC Genomics, 16, 331. (doi: 10.1186/s12864-015-1536-y) (PMID:25896062) (PMCID:PMC4428239)
2014
Britton, C. , Winter, A. D., Gillan, V. and Devaney, E. (2014) microRNAs of parasitic helminths – identification, characterization and potential as drug targets. International Journal for Parasitology: Drugs and Drug Resistance, 4(2), pp. 85-94. (doi: 10.1016/j.ijpddr.2014.03.001)
Gillan, V. and Devaney, E. (2014) Nematode Hsp90: highly conserved but functionally diverse. Parasitology, 141(9), pp. 1-13. (doi: 10.1017/S0031182014000304) (PMID:24721950)
Gillan, V. , O’Neill, K., Maitland, K. , Sverdrup, F. M. and Devaney, E. (2014) A repurposing strategy for Hsp90 inhibitors demonstrates their potency against filarial nematodes. PLoS Neglected Tropical Diseases, 8(2), e2699. (doi: 10.1371/journal.pntd.0002699) (PMID:24551261) (PMCID:PMC3923716)
2010
Taldone, T., Gillan, V., Sun, W., Rodina, A., Patel, P., Maitland, K., O'Neill, K., Chiosis, G. and Devaney, E. (2010) Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90. PLoS Neglected Tropical Diseases, 4(6), e714. (doi: 10.1371/journal.pntd.0000714) (PMID:20559560) (PMCID:PMC2886105)
2009
Gillan, V. , Maitland, K. , McCormack, G., Him, N. A.I.I. and Devaney, E. (2009) Functional genomics of hsp-90 in parasitic and free-living nematodes. International Journal for Parasitology, 39(10), pp. 1071-1081. (doi: 10.1016/j.ijpara.2009.02.024)
Him, N.A.I.I.N., Gillan, V., Emes, R.D., Maitland, K. and Devaney, E. (2009) Hsp-90 and the biology of nematodes. BMC Evolutionary Biology, 9(254), pp. 1-13. (doi: 10.1186/1471-2148-9-254) (PMID:19849843) (PMCID:PMC2771018)
2008
Cordano, P., Gillan, V. , Bratlie, S., Bouvard, V., Banks, L., Tommasino, M. and Campo, M.S. (2008) The E6E7 oncoproteins of cutaneous human papillomavirus type 38 interfere with the interferon pathway. Virology, 377(2), pp. 408-418. (doi: 10.1016/j.virol.2008.04.036)
2005
Gillan, V. , Lawrence, R.A. and Devaney, E. (2005) B cells play a regulatory role in mice infected with the L3 of Brugia pahangi. International Immunology, 17, pp. 373-382. (doi: 10.1093/intimm/dxh217)
Gillan, V. and Devaney, E. (2005) Regulatory T cells modulate Th2 responses induced by Brugia pahangi third-stage larvae. Infection and Immunity, 73, pp. 4034-4042. (doi: 10.1128/IAI.73.7.4034-4042.2005)
2004
Gillan, V. and Devaney, E. (2004) Mosquito transmission modulates the immune response in mice infected with the L3 of Brugia pahangi. Parasite Immunology, 26, pp. 359-363.
2002
Devaney, E., Gillan, V. , Wheatley, I., Jenson, J., OConnor, R. and Balmer, P. (2002) Interleukin-4 influences the production of microfilariae in a mouse model of Brugia infection. Parasite Immunology, 24, pp. 29-37.
Articles
Gillan, V. , Simpson, D. M., Kinnaird, J., Maitland, K. , Shiels, B. and Devaney, E. (2019) Characterisation of infection associated microRNA and protein cargo in extracellular vesicles of Theileria annulata infected leukocytes. Cellular Microbiology, 21, e12969. (doi: 10.1111/cmi.12969) (PMID:30370674) (PMCID:PMC6492283)
Marks, N. D. et al. (2019) Profiling microRNAs through development of the parasitic nematode Haemonchus identifies nematode-specific miRNAs that suppress larval development. Scientific Reports, 9, 17594. (doi: 10.1038/s41598-019-54154-6) (PMID:31772378) (PMCID:PMC6879476)
Gillan, V. et al. (2017) Increased expression of a microRNA correlates with anthelmintic resistance in parasitic nematodes. Frontiers in Cellular and Infection Microbiology, 7, 452. (doi: 10.3389/fcimb.2017.00452) (PMID:29209592) (PMCID:PMC5701612)
Laing, R. , Gillan, V. and Devaney, E. (2017) Ivermectin - old drug, new tricks? Trends in Parasitology, 33(6), pp. 463-472. (doi: 10.1016/j.pt.2017.02.004) (PMID:28285851) (PMCID:PMC5446326)
Kinnaird, J. H., Singh, M., Gillan, V. , Weir, W. , Calder, E. D.D., Hostettler, I., Tatu, U., Devaney, E. and Shiels, B. R. (2017) Characterization of HSP90 isoforms in transformed bovine leukocytes infected with Theileria annulata. Cellular Microbiology, 19(3), e12669. (doi: 10.1111/cmi.12669) (PMID:27649068) (PMCID:PMC5333456)
Devaney, E. and Gillan, V. (2016) Hsp90 inhibitors in parasitic nematodes: prospects and challenges. Current Topics in Medicinal Chemistry, 16(25), pp. 2805-2811. (doi: 10.2174/1568026616666160413140502) (PMID:27072703)
Britton, C. , Winter, A. D., Marks, N. D., Gu, H., McNeilly, T. N., Gillan, V. and Devaney, E. (2015) Application of small RNA technology for improved control of parasitic helminths. Veterinary Parasitology, 212(1-2), pp. 47-53. (doi: 10.1016/j.vetpar.2015.06.003) (PMID:26095949) (PMCID:PMC4535316)
Winter, A. D. et al. (2015) A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites. BMC Genomics, 16, 331. (doi: 10.1186/s12864-015-1536-y) (PMID:25896062) (PMCID:PMC4428239)
Britton, C. , Winter, A. D., Gillan, V. and Devaney, E. (2014) microRNAs of parasitic helminths – identification, characterization and potential as drug targets. International Journal for Parasitology: Drugs and Drug Resistance, 4(2), pp. 85-94. (doi: 10.1016/j.ijpddr.2014.03.001)
Gillan, V. and Devaney, E. (2014) Nematode Hsp90: highly conserved but functionally diverse. Parasitology, 141(9), pp. 1-13. (doi: 10.1017/S0031182014000304) (PMID:24721950)
Gillan, V. , O’Neill, K., Maitland, K. , Sverdrup, F. M. and Devaney, E. (2014) A repurposing strategy for Hsp90 inhibitors demonstrates their potency against filarial nematodes. PLoS Neglected Tropical Diseases, 8(2), e2699. (doi: 10.1371/journal.pntd.0002699) (PMID:24551261) (PMCID:PMC3923716)
Taldone, T., Gillan, V., Sun, W., Rodina, A., Patel, P., Maitland, K., O'Neill, K., Chiosis, G. and Devaney, E. (2010) Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90. PLoS Neglected Tropical Diseases, 4(6), e714. (doi: 10.1371/journal.pntd.0000714) (PMID:20559560) (PMCID:PMC2886105)
Gillan, V. , Maitland, K. , McCormack, G., Him, N. A.I.I. and Devaney, E. (2009) Functional genomics of hsp-90 in parasitic and free-living nematodes. International Journal for Parasitology, 39(10), pp. 1071-1081. (doi: 10.1016/j.ijpara.2009.02.024)
Him, N.A.I.I.N., Gillan, V., Emes, R.D., Maitland, K. and Devaney, E. (2009) Hsp-90 and the biology of nematodes. BMC Evolutionary Biology, 9(254), pp. 1-13. (doi: 10.1186/1471-2148-9-254) (PMID:19849843) (PMCID:PMC2771018)
Cordano, P., Gillan, V. , Bratlie, S., Bouvard, V., Banks, L., Tommasino, M. and Campo, M.S. (2008) The E6E7 oncoproteins of cutaneous human papillomavirus type 38 interfere with the interferon pathway. Virology, 377(2), pp. 408-418. (doi: 10.1016/j.virol.2008.04.036)
Gillan, V. , Lawrence, R.A. and Devaney, E. (2005) B cells play a regulatory role in mice infected with the L3 of Brugia pahangi. International Immunology, 17, pp. 373-382. (doi: 10.1093/intimm/dxh217)
Gillan, V. and Devaney, E. (2005) Regulatory T cells modulate Th2 responses induced by Brugia pahangi third-stage larvae. Infection and Immunity, 73, pp. 4034-4042. (doi: 10.1128/IAI.73.7.4034-4042.2005)
Gillan, V. and Devaney, E. (2004) Mosquito transmission modulates the immune response in mice infected with the L3 of Brugia pahangi. Parasite Immunology, 26, pp. 359-363.
Devaney, E., Gillan, V. , Wheatley, I., Jenson, J., OConnor, R. and Balmer, P. (2002) Interleukin-4 influences the production of microfilariae in a mouse model of Brugia infection. Parasite Immunology, 24, pp. 29-37.
