Dr Simon Babayan

  • Research Fellow (Institute of Biodiversity Animal Health and Comparative Medicine)
  • Associate - Life Sciences (School of Life Sciences)

telephone: 0141 330 6632
email: Simon.Babayan@glasgow.ac.uk

Research interests

Research Interests - Further Information

Google Scholar - Publications Profile

I am interested in the mechanisms that underlie protective immunity and disease: the phenotypes immune cells adopt to mitigate disease, and how to detect and quantify protective immune profiles in laboratory models, domesticated animals, and in natural populations.

To make progress in my overarching goal of improving medical interventions against infectious disease, I am following three intertwined lines of research:

  1. How do immune-mediated host-parasite interactions affect parasite fitness? (protective immunity vs. parasite immune evasion)
  2. How does the immune system integrate the myriad sources of natural variation to maintain health? (wild immunology)
  3. How to design safe and more effective vaccines? (nature-proof vaccines)

More specifically, I study how parasitic helminths are affected by host immune responses as a function of parasite immune evasion and immune protective efficacy; how protective immunity is affected by variation in host sex, nutrition, age, and coinfection; and for the past few years I have been developing anti-filarial vaccines that target parasite immune modulators and thus limit the ability of these worms to evade host immune responses.

To address these questions, I combine lab-based and field-based studies. The former allow the analysis of molecular and cellular responses to tightly controlled infections, diets and age structures, whereas the latter give insight into how such responses affect population-level dynamics such as morbidity/mortality rates and disease transmission.

This work therefore bridges a number of disciplines - mainly parasitology, immunology, ecology, and computational biology - and requires (attempting at least some) integration of immunity at the molecular, cellular, organismal, and population levels.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • United States-UK partnering award:Co-infection and resistance (CORE)
    Biotechnology and Biological Sciences Research Council
    2016 - 2020
     
  • ISSF Catalyst: Transcriptomic predictors of acquired immunity to Bovine TB in vaccinated Eurasian Badgers
    Wellcome Trust
    2015 - 2016
     
  • Dissecting variation in host responsiveness to a recombinant vaccine designed to control teladorsagiosis in sheep
    Biotechnology and Biological Sciences Research Council
    2015 - 2018
     
  • Wild Immunomics: characterising protective immunity to helminth infection by integrating transcriptomes and metabolomes of wild rodents (ISSF Catalyst)
    Wellcome Trust
    2013 - 2014
     

Publications

List by: Type | Date

Jump to: 2017 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2003 | 2002 | 2001
Number of items: 29.

2017

Capilla-Lasheras, P., Dominoni, D. M., Babayan, S. A., O'Shaughnessy, P. J., Mladenova, M., Woodford, L., Pollock, C. J., Barr, T., Baldini, F. and Helm, B. (2017) Elevated immune gene expression is associated with poor reproductive success of urban blue tits. Frontiers in Ecology and Evolution, 5, 64. (doi:10.3389/fevo.2017.00064)

Quintana, J.F., Babayan, S.A. and Buck, A.H. (2017) Small RNAs and extracellular vesicles in filarial nematodes: from nematode development to diagnostics. Parasite Immunology, 39(2), e12395. (doi:10.1111/pim.12395) (PMID:27748953)

2015

Makepeace, B. L., Babayan, S. A., Lustigman, S. and Taylor, D. W. (2015) The case for vaccine development in the strategy to eradicate river blindness (onchocerciasis) from Africa. Expert Review of Vaccines, 14(9), pp. 1163-1165. (doi:10.1586/14760584.2015.1059281) (PMID:26091691)

Quintana, J. F. et al. (2015) Extracellular onchocerca-derived small RNAs in host nodules and blood. Parasites and Vectors, 8, 58. (doi:10.1186/s13071-015-0656-1) (PMID:25623184) (PMCID:4316651)

2014

Armstrong, S. D. et al. (2014) Comparative analysis of the secretome from a model filarial nematode (Litomosoides sigmodontis) reveals maximal diversity in gravid female parasites. Molecular and Cellular Proteomics, 13(10), pp. 2527-2544. (doi:10.1074/mcp.M114.038539)

Buck, A. H. et al. (2014) Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity. Nature Communications, 5(5488), (doi:10.1038/ncomms6488)

Hewitson, J. P., Rückerl, D., Harcus, Y., Murray, J., Webb, L. M., Babayan, S. A., Allen, J. E., Kurniawan, A. and Maizels, R. M. (2014) The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo. PLoS Pathogens, 10(2), e1003930. (doi:10.1371/journal.ppat.1003930)

2013

Comandatore, F. et al. (2013) Phylogenomics and analysis of shared genes suggest a single transition to mutualism in Wolbachia of nematodes. Genome Biology and Evolution, 5(9), pp. 1668-1674. (doi:10.1093/gbe/evt125)

2012

Babayan, S.A., Allen, J.E. and Taylor, D.W. (2012) Future prospects and challenges of vaccines against filariasis. Parasite Immunology, 34(5), pp. 243-253. (doi:10.1111/j.1365-3024.2011.01350.x)

Little, T.J., Allen, J.E., Babayan, S.A., Matthews, K.R. and Colegrave, N. (2012) Harnessing evolutionary biology to combat infectious disease. Nature Medicine, 18(2), pp. 217-220. (doi:10.1038/nm.2572)

Babayan, S.A., Luo, H., Gray, N., Taylor, D.W. and Allen, J.E. (2012) Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes. PLoS Neglected Tropical Diseases, 6(12), e1968. (doi:10.1371/journal.pntd.0001968)

Babayan, S.A. and Schneider, D.S. (2012) Immunity in society: diverse solutions to common problems. PLoS Biology, 10(4), e1001297. (doi:10.1371/journal.pbio.1001297)

2011

Babayan, S.A. et al. (2011) Wild immunology: converging on the real world. Annals of the New York Academy of Sciences, 1236(1), pp. 17-29. (doi:10.1111/j.1749-6632.2011.06251.x)

Coltherd, J.C., Babayan, S.A., Bunger, L., Kyriazakis, I., Allen, J.E. and Houdijk, J.G.M. (2011) Interactive effects of protein nutrition, genetic growth potential and heligmosomoides bakeri infection pressure on resilience and resistance in mice. Parasitology, 138(10), pp. 1305-1315. (doi:10.1017/S0031182011000990)

Pedersen, A.B. and Babayan, S.A. (2011) Wild immunology. Molecular Ecology, 20(5), pp. 872-880. (doi:10.1111/j.1365-294X.2010.04938.x)

2010

Babayan, S.A., Read, A.F., Lawrence, R.A., Bain, O. and Allen, J.E. (2010) Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy. PLoS Biology, 8(10), e1000525. (doi:10.1371/journal.pbio.1000525)

2009

Coltherd, J.C., Babayan, S., Bünger, L., Kyriazakis, I., Allen, J.E. and Houdijk, J.G.M. (2009) Immune responses to macroparasites are sensitive to the interaction between genetic growth potential and protein nutrition in mice. Proceedings of the Nutrition Society, 68(OCE3), E101. (doi:10.1017/S0029665109990577)

2008

Attout, T., Martin, C., Babayan, S.A., Kozek, W.J., Bazzocchi, C., Oudet, F., Gallagher, I.J., Specht, S. and Bain, O. (2008) Pleural cellular reaction to the filarial infection litomosoides sigmodontis is determined by the moulting process, the worm alteration, and the host strain. Parasitology International, 57(2), pp. 201-211. (doi:10.1016/j.parint.2008.01.001)

Houston, K.M., Babayan, S., Allen, J.E. and Harnett, W. (2008) Does litomosoides sigmodontis synthesize dimethylethanolamine from choline? Parasitology, 135(01), pp. 55-61. (doi:10.1017/S0031182007003642)

2007

Taylor, M.D., Harris, A., Babayan, S.A., Bain, O., Culshaw, A., Allen, J.E. and Maizels, R.M. (2007) CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo. Journal of Immunology, 179(7), pp. 4626-4634.

2006

Babayan, S.A., Attout, T., Harris, A., Taylor, M.D., Legoff, L., Vuong, P.N., Renia, L., Allen, J.E. and Bain, O. (2006) Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages. International Journal for Parasitology, 36(8), pp. 903-914. (doi:10.1016/j.ijpara.2006.04.013)

2005

Babayan, S., Attout, T., Specht, S., Hoerauf, A., Snounou, G., Rénia, L., Korenaga, M., Bain, O. and Martin, C. (2005) Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria litomosoides sigmodontis. Medical Microbiology and Immunology, 194(3), pp. 151-162. (doi:10.1007/s00430-004-0226-1)

Attout, T., Babayan, S., Hoerauf, A., Taylor, D.W., Kozek, W.J., Martin, C. and Bain, O. (2005) Blood-feeding in the young adult filarial worms litomosoides sigmodontis. Parasitology, 130(4), pp. 421-428.

Babayan, S.A., Attout, T., Vuong, P.N., Le Goff, L., Gantier, J. and Bain, O. (2005) The subcutaneous movements of filarial infective larvae are impaired in vaccinated hosts in comparison to primary infected hosts. Filaria Journal, 4(3), (doi:10.1186/1475-2883-4-3)

2003

Babayan, S., Ungeheuer, M., Martin, C., Attout, T., Belnoue, E., Snounou, G., Rénia, L., Korenaga, M. and Bain, O. (2003) Resistance and susceptibility to filarial infection with litomosoides sigmodontis are associated with early differences in parasite development and in localized immune reactions. Infection and Immunity, 71(12), pp. 6820-6829. (doi:10.1128/IAI.71.12.6820-6829.2003)

Bain, O., Guerrero, R., Rodriguez, B., Babayan, S. and Jouvenet, N. (2003) Examination of type material of two species of litomosoides (filarioidea: onchocercidae), parasites from bats; taxonomic consequences. Parasite, 10(3), pp. 211-8.

Bain, O. and Babayan, S. (2003) Behaviour of filariae: morphological and anatomical signatures of their life style within the arthropod and vertebrate hosts. Filaria Journal, 2(16), (doi:10.1186/1475-2883-2-16)

2002

Bain, O., Babayan, S., Gomes, J., Rojas, G. and Guerrero, R. (2002) First account on the larval biology of a litomosoides filaria, from a bat. Parassitologia, 44(1-2), pp. 89-92.

2001

Martin, C., Saeftel, M., Vuong, P.N., Babayan, S., Fischer, K., Bain, O. and Hoerauf, A. (2001) B-cell deficiency suppresses vaccine-induced protection against murine filariasis but does not increase the recovery rate for primary infection. Infection and Immunity, 69(11), pp. 7067-7073. (doi:10.1128/IAI.69.11.7067-7073.2001)

This list was generated on Tue Oct 17 20:03:54 2017 BST.
Jump to: Articles
Number of items: 29.

Articles

Capilla-Lasheras, P., Dominoni, D. M., Babayan, S. A., O'Shaughnessy, P. J., Mladenova, M., Woodford, L., Pollock, C. J., Barr, T., Baldini, F. and Helm, B. (2017) Elevated immune gene expression is associated with poor reproductive success of urban blue tits. Frontiers in Ecology and Evolution, 5, 64. (doi:10.3389/fevo.2017.00064)

Quintana, J.F., Babayan, S.A. and Buck, A.H. (2017) Small RNAs and extracellular vesicles in filarial nematodes: from nematode development to diagnostics. Parasite Immunology, 39(2), e12395. (doi:10.1111/pim.12395) (PMID:27748953)

Makepeace, B. L., Babayan, S. A., Lustigman, S. and Taylor, D. W. (2015) The case for vaccine development in the strategy to eradicate river blindness (onchocerciasis) from Africa. Expert Review of Vaccines, 14(9), pp. 1163-1165. (doi:10.1586/14760584.2015.1059281) (PMID:26091691)

Quintana, J. F. et al. (2015) Extracellular onchocerca-derived small RNAs in host nodules and blood. Parasites and Vectors, 8, 58. (doi:10.1186/s13071-015-0656-1) (PMID:25623184) (PMCID:4316651)

Armstrong, S. D. et al. (2014) Comparative analysis of the secretome from a model filarial nematode (Litomosoides sigmodontis) reveals maximal diversity in gravid female parasites. Molecular and Cellular Proteomics, 13(10), pp. 2527-2544. (doi:10.1074/mcp.M114.038539)

Buck, A. H. et al. (2014) Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity. Nature Communications, 5(5488), (doi:10.1038/ncomms6488)

Hewitson, J. P., Rückerl, D., Harcus, Y., Murray, J., Webb, L. M., Babayan, S. A., Allen, J. E., Kurniawan, A. and Maizels, R. M. (2014) The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo. PLoS Pathogens, 10(2), e1003930. (doi:10.1371/journal.ppat.1003930)

Comandatore, F. et al. (2013) Phylogenomics and analysis of shared genes suggest a single transition to mutualism in Wolbachia of nematodes. Genome Biology and Evolution, 5(9), pp. 1668-1674. (doi:10.1093/gbe/evt125)

Babayan, S.A., Allen, J.E. and Taylor, D.W. (2012) Future prospects and challenges of vaccines against filariasis. Parasite Immunology, 34(5), pp. 243-253. (doi:10.1111/j.1365-3024.2011.01350.x)

Little, T.J., Allen, J.E., Babayan, S.A., Matthews, K.R. and Colegrave, N. (2012) Harnessing evolutionary biology to combat infectious disease. Nature Medicine, 18(2), pp. 217-220. (doi:10.1038/nm.2572)

Babayan, S.A., Luo, H., Gray, N., Taylor, D.W. and Allen, J.E. (2012) Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes. PLoS Neglected Tropical Diseases, 6(12), e1968. (doi:10.1371/journal.pntd.0001968)

Babayan, S.A. and Schneider, D.S. (2012) Immunity in society: diverse solutions to common problems. PLoS Biology, 10(4), e1001297. (doi:10.1371/journal.pbio.1001297)

Babayan, S.A. et al. (2011) Wild immunology: converging on the real world. Annals of the New York Academy of Sciences, 1236(1), pp. 17-29. (doi:10.1111/j.1749-6632.2011.06251.x)

Coltherd, J.C., Babayan, S.A., Bunger, L., Kyriazakis, I., Allen, J.E. and Houdijk, J.G.M. (2011) Interactive effects of protein nutrition, genetic growth potential and heligmosomoides bakeri infection pressure on resilience and resistance in mice. Parasitology, 138(10), pp. 1305-1315. (doi:10.1017/S0031182011000990)

Pedersen, A.B. and Babayan, S.A. (2011) Wild immunology. Molecular Ecology, 20(5), pp. 872-880. (doi:10.1111/j.1365-294X.2010.04938.x)

Babayan, S.A., Read, A.F., Lawrence, R.A., Bain, O. and Allen, J.E. (2010) Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy. PLoS Biology, 8(10), e1000525. (doi:10.1371/journal.pbio.1000525)

Coltherd, J.C., Babayan, S., Bünger, L., Kyriazakis, I., Allen, J.E. and Houdijk, J.G.M. (2009) Immune responses to macroparasites are sensitive to the interaction between genetic growth potential and protein nutrition in mice. Proceedings of the Nutrition Society, 68(OCE3), E101. (doi:10.1017/S0029665109990577)

Attout, T., Martin, C., Babayan, S.A., Kozek, W.J., Bazzocchi, C., Oudet, F., Gallagher, I.J., Specht, S. and Bain, O. (2008) Pleural cellular reaction to the filarial infection litomosoides sigmodontis is determined by the moulting process, the worm alteration, and the host strain. Parasitology International, 57(2), pp. 201-211. (doi:10.1016/j.parint.2008.01.001)

Houston, K.M., Babayan, S., Allen, J.E. and Harnett, W. (2008) Does litomosoides sigmodontis synthesize dimethylethanolamine from choline? Parasitology, 135(01), pp. 55-61. (doi:10.1017/S0031182007003642)

Taylor, M.D., Harris, A., Babayan, S.A., Bain, O., Culshaw, A., Allen, J.E. and Maizels, R.M. (2007) CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo. Journal of Immunology, 179(7), pp. 4626-4634.

Babayan, S.A., Attout, T., Harris, A., Taylor, M.D., Legoff, L., Vuong, P.N., Renia, L., Allen, J.E. and Bain, O. (2006) Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages. International Journal for Parasitology, 36(8), pp. 903-914. (doi:10.1016/j.ijpara.2006.04.013)

Babayan, S., Attout, T., Specht, S., Hoerauf, A., Snounou, G., Rénia, L., Korenaga, M., Bain, O. and Martin, C. (2005) Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria litomosoides sigmodontis. Medical Microbiology and Immunology, 194(3), pp. 151-162. (doi:10.1007/s00430-004-0226-1)

Attout, T., Babayan, S., Hoerauf, A., Taylor, D.W., Kozek, W.J., Martin, C. and Bain, O. (2005) Blood-feeding in the young adult filarial worms litomosoides sigmodontis. Parasitology, 130(4), pp. 421-428.

Babayan, S.A., Attout, T., Vuong, P.N., Le Goff, L., Gantier, J. and Bain, O. (2005) The subcutaneous movements of filarial infective larvae are impaired in vaccinated hosts in comparison to primary infected hosts. Filaria Journal, 4(3), (doi:10.1186/1475-2883-4-3)

Babayan, S., Ungeheuer, M., Martin, C., Attout, T., Belnoue, E., Snounou, G., Rénia, L., Korenaga, M. and Bain, O. (2003) Resistance and susceptibility to filarial infection with litomosoides sigmodontis are associated with early differences in parasite development and in localized immune reactions. Infection and Immunity, 71(12), pp. 6820-6829. (doi:10.1128/IAI.71.12.6820-6829.2003)

Bain, O., Guerrero, R., Rodriguez, B., Babayan, S. and Jouvenet, N. (2003) Examination of type material of two species of litomosoides (filarioidea: onchocercidae), parasites from bats; taxonomic consequences. Parasite, 10(3), pp. 211-8.

Bain, O. and Babayan, S. (2003) Behaviour of filariae: morphological and anatomical signatures of their life style within the arthropod and vertebrate hosts. Filaria Journal, 2(16), (doi:10.1186/1475-2883-2-16)

Bain, O., Babayan, S., Gomes, J., Rojas, G. and Guerrero, R. (2002) First account on the larval biology of a litomosoides filaria, from a bat. Parassitologia, 44(1-2), pp. 89-92.

Martin, C., Saeftel, M., Vuong, P.N., Babayan, S., Fischer, K., Bain, O. and Hoerauf, A. (2001) B-cell deficiency suppresses vaccine-induced protection against murine filariasis but does not increase the recovery rate for primary infection. Infection and Immunity, 69(11), pp. 7067-7073. (doi:10.1128/IAI.69.11.7067-7073.2001)

This list was generated on Tue Oct 17 20:03:54 2017 BST.