Dr Douglas Morrison
- Reader (Scottish Universities Environmental Research Centre)
Design and synthesis of novel metaprobes
Metaprobes are isotopically labelled molecular probes for measuring metabolic process in vivo. They are designed to release the isotope labelled probe at the correct physiological site e.g. the colon for studies of bacterial metabolism.
Exploiting natural isotopic abundance variances (C3 vs. C4 plant carbohydrates) and stable isotope enrichment studies to determine the fate of dietary carbohydrates through digestion and fermentation and the impact of these processes on health and disease.
Gut bacteria in health and disease
Development of in vitro and in vivo stable isotope methods to probe the function and activity of bacteria within the gut in health and disease.
Compound-specific isotope analysis
Development of GC and LC based methods for online compound specific isotope analysis.
Development of instrumental platforms for analysis of multiple, isotopically labelled metabolites and design of tracers to probe the flux through targeted metabolic pathways in biological systems.
Targeting Appetite Regulation by Nutrient Delivery in the Gut. BBSRC Super Follow on Funding. 2012-2014.
Seeing the full spectrum: An integrated approach to characterization of Martian carbon. The Carnegie Trust for the Universities of Scotland. 2013-2014.
Next generation carbohydrates for appetite regulation. MRC. 2012-2016.
Emulsion structure: a novel mechanism of delivering fatty acids to regulate gut function and satiety. BBSRC. 2011-2014.
SCFA and satiety. Strategic Partnership Scheme, Scottish Government (RESAS). 2011-2016.
Drivers of propionate production in the colon. BBSRC. 2011-2015.
Increased propionate production in the colon is associated with reduced appetite, body weight and improved insulin sensitivity. BBSRC. 2009-2012.
East Kilbride G75 0QF,