Research

Henderson, L. A., Mitchell, T., Steele, C. W., Roxburgh, C. S. D., Knight, K. A. (2026) A systematic review and meta-analysis of blood-based biomarkers in anal squamous cell cancer treated with chemoradiotherapy. Critical Reviews in Oncology/Hematology, 221, (doi: 10.1016/j.critrevonc.2026.105215)

Pea, A., He, X., Upstill-Goddard, R., Luchini, C., Schubert Santana, L. P., Dreyer, S., Duthie, F., Jamieson, N. B., McKay, C. J., Dickson, E. J., Pulvirenti, A., Rebus, S., Genomics Innovation Alliance, ., Scottish Genome Partnership, ., Piccoli, P., Sperandio, N., Lawlor, R. T., Milella, M., Froeling, F. E.M., Salvia, R., Scarpa, A., Bainkin, A. V., Wedge, D. C., Chang, D. K. (2026) Clonal evolutionary analysis reveals patterns of malignant transformation of Intraductal Papillary Mucinous Neoplasms of the pancreas. Nature Communications, (doi: 10.1038/s41467-026-69762-w)

Himonas, E., de Beauchamp, L., Zerbst, D., Desmares-Romain, E., Sarnello, D., Kalkman, E., Rattigan, K., James, D., Shokry, E., Copland, M., Griessinger, E., Récher, C., de Mas, V., Vergez, F., Sumpton, D., Schimmer, A., Minden, M., Gottlieb, E., Shanks, E., Sarry, J.-E., Helgason, V. (2026) A metabolism-specific drug-repurposing screen reveals itraconazole as a potent OXPHOS inhibitor in acute myeloid leukemia. Blood, (doi: 10.1182/blood.2024027853)

White, M. et al. (2026) MAPK-driven epithelial cell plasticity drives colorectal cancer therapeutic resistance. Nature, 650, pp. 748-758. (doi: 10.1038/s41586-025-09916-w)

Bryce, A. S., Martinelli, S., Schubert Santana, L., Officer-Jones, L., Baird, R. L., Ballantyne, F., Rakovic, K., Powley, I. R., Tataran, D., Meltzer, D. J., Walsh, C., Duthie, F., Farndale, L., Claudio Quiros, A., Yuan, K., Le Quesne, J., Froeling, F. E.M., Dreyer, S. B., Chang, D. K. (2026) Morphospatial profiling of cancer-associated fibroblasts reveals architectural subtypes of pancreatic ductal adenocarcinoma. bioRxiv, (doi: 10.64898/2026.02.06.704414)

Hillson, L. V.S. et al. (2026) Differential immunologic effects of short-course and long-course radiotherapy in locally advanced rectal cancer. Clinical Cancer Research, (doi: 10.1158/1078-0432.CCR-25-2733)

Patterson, S.D., Gottschalk, A., Hayden, C., Young, R., Hair, A., Jørgensen, H.G., Wheadon, H.W., Apperley, J.F., Glauche, I., Clark, R.E., Copland, M., Roeder, I. (2026) Sequential BCR::ABL1 evaluation during dose de-escalation in peripheral blood is more predictive of TFR success than single assessment at dose de-escalation in either peripheral blood or bone marrow. Leukemia, 40, pp. 459-463. (doi: 10.1038/s41375-025-02853-7)

Centeno, P. P., Chester, C., Kanellos, G., Ford, C. A., Cammarezi, P., Inman, G. J., Jamieson, T., Ridgeway, R. A., Marais, R., Campbell, A. D., Sansom, O. J. (2026) SOX2 confers tumour permissiveness in a specific skin progenitor population. Nature Communications, 17, (doi: 10.1038/s41467-025-66251-4)

Ren, H., Elliott, N., Lye, B., Sharif Shohan, M. U., Cross, J. W., Field, L., Ponnusamy, K., Rice, S., Jackson, T., Ilia, L., El Ouazzani, N., Thomas, R., Inglott, S., Bartram, J., Smith, O., Bond, J., Roberts, I. A. G., Halsey, C., Bashford-Rogers, R., Milne, T. A., Roy, A., Karadimitris, A. (2026) 'Off-the-shelf' dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal KMT2A-rearranged leukemia. Blood, 147, pp. 180-196. (doi: 10.1182/blood.2025029302)

Keeshan, K. (2026) Fetal defense against leukemia: a developmental shield. Blood, 147, pp. 7-8. (doi: 10.1182/blood.2025031544)

Tham, A., McMillan, D. C., Talwar, D., McSorley, S. T. (2026) Adjusting iron markers for inflammation reduces misclassification of iron deficiency after total hip arthroplasty. Journal of Clinical Medicine, 15, (doi: 10.3390/jcm15010259)

Banales, J. M. et al. (2026) Cholangiocarcinoma 2026: status quo, unmet needs and priorities. Nature Reviews Gastroenterology and Hepatology, 23, pp. 65-96. (doi: 10.1038/s41575-025-01153-w)

Smith, C. D.L., McMahon, A. D., Inman, G. J., Conway, D. I., Douglas, C. M., Paterson, C. (2026) The COVID-19 pandemic has not influenced survival outcomes of head and neck cancer squamous cell carcinomas in the West of Scotland: a retrospective cohort study. BJC Reports, 4, (doi: 10.1038/s44276-026-00203-3)

Kanellos, G. et al. (2025) Nucleophosmin supports WNT-driven hyperproliferation and tumour initiation. Nature Genetics, (doi: 10.1038/s41588-025-02408-7)

Kong, C. Y., Galbraith, N. J., McCormick, A., Haddock, A., Ratcliffe, M., Telfer, J., Lo, S., Fairbairn, N., Palmer, M., Teahan, S., Morton, S., Lindsay, R., Burton, K., Siddiqui, N., Roxburgh, C., Chong, P. S., Steele, C. W., Quinn, M. (2025) Resecting beyond the central pelvic compartment in pelvic exenterations for gynaecological malignancies: outcomes from a tertiary unit. Australian and New Zealand Journal of Obstetrics and Gynaecology, (doi: 10.1111/ajo.70079)

Gajic, N., Christie, R., Martin, J., Josephs-Spaulding, J., Lam, S., Ackermann, T., Dunn, K., Shokry, E., Huerta Uribe, A., Irving, J., van Delft, F., de Muyer, F., Ntziachristos, P., Vande Voorde, J., Sumpton, D., Tardito, S., Brown, A., Tait, S., Halsey, C. (2025) NADPH Controls a Cell State Vulnerability Towards Ferroptosis in Acute Lymphoblastic Leukaemia. (doi: 10.1182/blood-2025-144)

Gajic, N., Christie, R., Lam, S., Ackermann, T., Himonas, E., Josephs-Spaulding, J., Manoharan, A., Assmann, V., Martin, J., Collings, A., Dunn, K., Shokry, E., Huerta Uribe, A., Burns, S., O'Connor, D., Mansour, M., Sumpton, D., Helgason, G. V., Vande Voorde, J., Tardito, S., Tait, S., Halsey, C. (2025) Selenocysteine Dependency Renders Central Nervous System Leukaemia Therapeutically Sensitive to Ferroptosi. (doi: 10.1182/blood-2025-1526)

Duguid, A., Malouf, C., Nitsche, L., Halsey, C., Ottersbach, K. (2025) Mixed-lineage leukaemia cells undergo unique adaptations in the CNS niche. Experimental Hematology, (doi: 10.1016/j.exphem.2025.105347)

Mikkelsen, T., Helenius, M., Ampatzidou, M., Attarbaschi, A., Andres-Jensen, L., Borkhardt, A., Cuevas, N., Escherich, G., Hagleitner, M., Halsey, C., Josephs-Spaulding, J., Lundgren, L., Pehn, S., Polychronopoulou, S., Stoltze, U., Toksvang, L., Wahlberg, A., Junk, S., Schmiegelow, K. (2025) Role of common host genome variants in Childhood Acute Lymphoblastic Leukemia. Leukemia, (doi: 10.1038/s41375-025-02804-2)

Cong, B., Stamou, E., Pennel, K., Thakur, T., McKenzie, M., Matly, A., Gilroy, K., Shah, H., Gopinath, S., Edwards, J., Cagan, R. (2025) WNT signalling promotes NF-κB activation and drug resistance in KRAS-mutant colorectal cancer. EMBO Reports, 26, pp. 5728-5755. (doi: 10.1038/s44319-025-00588-1)

Lourenço, F. C., Sadien, I. D., Wong, K., Adler, S., Sawle, A., Schubert Santana, L., Hazelwood, L., Giavara, G., Nicholson, A. M., Eldridge, M. D., Maka, N., Lynch, G., McSorley, S. T., Edwards, J., Kemp, R., Adams, D. J., Winton, D. J. (2025) Decay of driver mutations shapes the landscape of intestinal transformation. Nature, (doi: 10.1038/s41586-025-09762-w)

Glover, H. L., Tait, S. W.G. (2025) A fat-fueled fatality. Nature Chemical Biology, 21, pp. 1833-1834. (doi: 10.1038/s41589-025-01932-1)

Ponce-Garcia, F. M., Jenkins, Y. R., Assmann, V. D., Paul, S., Sharma, N. D., Moore, C., Ma, E. H., Diamanti, P., Hennequart, M., Blagih, J., Le, L., Jenkins, B. J., Rouvray, S., Cronin, J. G., Jones, R. G., Mansour, M., Blair, A., Halsey, C., Matlawska-Wasowska, K., Herranz, D., Vincent, E. E., Jones, N. (2025) Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia. Molecular Metabolism, 102, (doi: 10.1016/j.molmet.2025.102275)

Rimini, M. et al. (2025) Durvalumab in advanced biliary tract cancer: real-world data from a large cohort of patients across multiple international centers. Liver International, 45, (doi: 10.1111/liv.70428)

Raven, A. et al. (2025) Hepatic zonation determines tumorigenic potential of mutant β-catenin. Nature, (doi: 10.1038/s41586-025-09733-1)

Malik, A. K., Geh, D., Evans, T. R. J., Chow, P. K.H., Mann, D. A., White, S. A. (2025) Improving surgical treatments for hepatocellular carcinoma. Nature Reviews Gastroenterology and Hepatology, (doi: 10.1038/s41575-025-01143-y)

Bilsland, A. E., Degerman, S., Landfors, M., Wadsley, J., Wall, L., Thompson, C., Damyanova, I., Samuel, L., Petty, R., Jain, A., Lewsley, L.-A., MacMillan, A., MacLeod, M., Walker, J., McCormick, C., McCartney, E., Roxburgh, P., Stobo, J., Thomson, F., Evans, T.R. J., Keith, W. N. (2025) Relative telomere length and senescence-associated inflammatory cytokines as blood-based prognostic markers in patients with advanced or resectable gastro-oesophageal adenocarcinoma. British Journal of Cancer, (doi: 10.1038/s41416-025-03221-z)

Roche, J. J., Seyedshahi, F., Rakovic, K., Thu, A. W., Le Quesne, J., Blyth, K. G. (2025) Current and future applications of artificial intelligence in lung cancer and mesothelioma. Thorax, 80, pp. 957-965. (doi: 10.1136/thorax-2024-222054)

Young, J., Edwards, J., Park, J. H. (2025) The epidemiology, current evidence and controversies in diagnosis and management of patients with colorectal peritoneal metastases. Surgeon, (doi: 10.1016/j.surge.2025.11.001)

Knox, J. J. et al. (2025) PASS-01: Randomized Phase II Trial of Modified FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel and Molecular Correlatives for Previously Untreated Metastatic Pancreatic Cancer. Journal of Clinical Oncology, 43, pp. 3355-3368. (doi: 10.1200/JCO-25-00436)

Olaizola, I. et al. (2025) New platinum derivatives selectively cause double-strand DNA breaks and death in naïve and cisplatin-resistant cholangiocarcinomas. Journal of Hepatology, 83, pp. 1077-1091. (doi: 10.1016/j.jhep.2025.04.034)

Duncan, S., Kidd, A. C., Perdomo Lampignano, J., Cannon, P., Hall, M., Stobo, D. B., Maclay, J. D., Blyth, K. G., Lowe, D. J. (2025) Reference standard methodology in the clinical evaluation of AI chest X-ray algorithms for lung cancer detection: A systematic review. European Journal of Radiology, 192, (doi: 10.1016/j.ejrad.2025.112409)

Amaral, P., Christie, R., Gresham, D. O.F., Lucas, E. J.M., Xu, L. K., Behrmann, L., Bond, J., Degerman, S., van Delft, F. W., Goossens, S., Hagleitner, M., Halsey, C., Jones, N., Lammens, T., van Leeuwen, F. N., Mansour, M. R., Ntziachristos, P., O’Connor, D., Barata, J. T. (2025) Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia. Leukemia, 39, pp. 2575-2589. (doi: 10.1038/s41375-025-02723-2)

Browne, I. M., Pascual, J., Cutts, R. J., Kingston, B., Hrebien, S., Kilburn, L. S., Pearson, A., Moretti, L., Wardley, A. M., MacPherson, I. R., Baird, R. D., Roylance, R., Gil-Gil, M. J., Guerrero-Zotano, A. L., Garcia-Murillas, I., Bliss, J. M., Ring, A., Martín, M., Turner, N. C. (2025) The prognostic and predictive impact of circulating tumour DNA levels in patients with advanced breast cancer enrolled on the plasmaMATCH trial. Clinical Cancer Research, (doi: 10.1158/1078-0432.CCR-24-0651)

Galloway, A., Knop, K., Gomez-Moreira, C., Xavier, V., Thomson, S., Yoshikawa, H., Suska, O., Lukoszek, R., Kaskar, A., Lamond, A. I., MacVicar, T., Cowling, V. H. (2025) CMTR1 directs mitochondrial dynamics during T cell activation through epitranscriptomic regulation of splice isoforms. Cell Reports, 44, (doi: 10.1016/j.celrep.2025.116412)

Sharma, N. D., Keewan, E.’a., Ornatowski, W., Paul, S., Nysus, M., Barnett, C. C., Wolfson, J., Jacquez, Q., Myers, B. L., Kang, H., Zychowski, K. E., Winter, S. S., Loh, M. L., Hunger, S. P., Castillo, E. F., Taghon, T., Halsey, C., Vue, T. Y., Jones, N., Ntziachristos, P., Ksenia, M.-W. (2025) T-cell acute lymphoblastic leukemia exploits a neural proinflammatory pathway to colonize the meninges. Journal of Clinical Investigation, (doi: 10.1172/JCI188888)

Crellen, T., Vita, F., Braconi, C., Sithithaworn, P., Hollingsworth, T. D. (2025) Natural history of liver fluke infection underpins epidemiological patterns of biliary cancer. Proceedings of the National Academy of Sciences of the United States of America, 122, (doi: 10.1073/pnas.2423536122)

Bone, M., Inman, G. J. (2025) Alternative transcription increases isoform complexity in Long Non-Coding RNAs and alters their functions in cancer. Non-coding RNA Research, 14, pp. 38-50. (doi: 10.1016/j.ncrna.2025.04.008)

Salvador-Barbero, B., Alatsatianos, M., Morton, J. P., Sansom, O. J., Hogan, C. (2025) KRASG12D cells override homeostatic cell elimination mechanisms in adult pancreas via Wnt5a and cell dormancy. Gastroenterology, 169, pp. 983-999.e21. (doi: 10.1053/j.gastro.2025.02.042)

Rimini, M. et al. (2025) The impact of molecular alterations in patients with advanced biliary tract cancer receiving cisplatin, gemcitabine and durvalumab: a large real-life worldwide population. Journal of the National Cancer Institute, 117, pp. 2029-2043. (doi: 10.1093/jnci/djaf155)

Mallu, A. C. T., Coffelt, S. B. (2025) γδT cells and breast cancer: wicked allies. Trends in Cancer, 11, pp. 920-922. (doi: 10.1016/j.trecan.2025.08.015)

Ahmed Hassan Elshiekh, A., Tait, S. W.G. (2025) Molecular cell biology of apoptosis in health and disease. Springer Nature

Tesini, G., Ibrahim, H., Rimassa, L., Braconi, C. (2025) Evolving precision: updates in targeted therapy for cholangiocarcinoma. Hepatology, (doi: 10.1097/HEP.0000000000001541)

Rimini, M. et al. (2025) Factors associated with reaching maintenance therapy in patients with advanced biliary tract cancer treated with durvalumab: real‐world results from a multicenter and multinational study. International Journal of Cancer, 157, pp. 1246-1259. (doi: 10.1002/ijc.35481)

Mills, J. G., Hepburn, L. A., Cowling, V. H. (2025) RNMT-dependent RNA cap methylation in health and disease. Biochemical Journal, 482, (doi: 10.1042/BCJ20253170)

Dobbin, S. J. H., Mangion, K., Berry, C., Roditi, G., Basak, S., McClure, J. D., Brooksbank, K., Sonecki, P., Sourbron, S., Evans, J., White, J., Welsh, P., Butler, E., Venugopal, B., Touyz, R. M., Jones, R. J., Petrie, M. C., Lang, N. N. (2025) Vascular endothelial growth factor inhibitor-induced cardiotoxicity: prospective multimodality assessment incorporating cardiovascular magnetic resonance imaging. Heart, 111, pp. 925-932. (doi: 10.1136/heartjnl-2024-325535)

Sofianidi, A. A., Syrigos, N. K., Blyth, K. G., Charpidou, A., Vathiotis, I. A. (2025) Breaking through: immunotherapy innovations in pleural mesothelioma. Clinical Lung Cancer, 26, pp. 458-469. (doi: 10.1016/j.cllc.2025.04.008)

Bone, M., Schreyer, D., Treanor-Taylor, M., Proby, C., Harwood, C., Leigh, I. M., Bailey, P., Inman, G. (2025) The landscape of long noncoding RNA during cutaneous squamous cell carcinoma progression. British Journal of Dermatology, 193, pp. 490-501. (doi: 10.1093/bjd/ljaf108)

Whyte, D. et al. (2025) Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes. EMBO Reports, 26, pp. 4248-4282. (doi: 10.1038/s44319-025-00520-7)

Cammareri, P. et al. (2025) Loss of colonic fidelity enables multilineage plasticity and metastasis. Nature, 644, pp. 547-556. (doi: 10.1038/s41586-025-09125-5)

Gounis, M., Campos, A. V., Shokry, E., Mitchell, L., Deshmukh, R., Dornier, E., Rooney, N., Dhayade, S., Pardo, L., Moore, M., Novo, D., Mowat, J., Jamieson, C., Kay, E., Zanivan, S., Paul, N. R., Mitchell, C., Nixon, C., MacPherson, I., Tardito, S., Sumpton, D., Blyth, K., Norman, J. C., Clarke, C. (2025) Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments. Journal of Cell Biology, 224, (doi: 10.1083/jcb.202405061)

Tate, M. et al. (2025) Clinical effectiveness, safety and viral mutagenicity of oral favipiravir for COVID-19: results from a community-based, open-label, randomised, phase III trial. Antimicrobial Agents and Chemotherapy, 69, (doi: 10.1128/aac.00054-25)

Herbert, K. J., Upstill-Goddard, R., Dreyer, S. B., Rebus, S., Pilarsky, C., Debabrata, M., Lord, C. J., Biankin, A. V., Froeling, F. E.M., Chang, D. K. (2025) Sequential ATR and PARP inhibition overcomes acquired DNA damaging agent resistance in pancreatic ductal adenocarcinoma. British Journal of Cancer, 133, pp. 381-393. (doi: 10.1038/s41416-025-03051-z)

Prinzi, F. L. et al. (2025) Negative impact of corticosteroid use on outcome in patients with advanced BTCs treated with cisplatin, gemcitabine, and durvalumab: a large real‐life worldwide population. International Journal of Cancer, (doi: 10.1002/ijc.70009)

Bullock, E., Rozyczko, A., Shabbir, S., Tsoupi, I., Young, A. I. J., Travnickova, J., Gómez-Cuadrado, L., Mabruk, Z., Carrasco, G., Morrow, E., Pennel, K., Kloosterman, P., Houthuijzen, J. M., Jonkers, J., Avalle, L., Poli, V., Iggo, R., Xiao, X., Guo, J., Zhu, X., Mallon, E., Edwards, J., Patton, E., Brunton, V. G. (2025) Cancer-associated fibroblast driven paracrine IL-6/STAT3 signaling promotes migration and dissemination in invasive lobular carcinoma. Breast Cancer Research, 27, (doi: 10.1186/s13058-025-02074-x)

Persano, M. et al. (2025) A prognostic index for advanced biliary tract cancer treated with cisplatin, gemcitabine and durvalumab: the MAGIC-D index. Liver International, 45, (doi: 10.1111/liv.70181)

Wood, H., O'Nions, J., Chan, W. Y., Borg, A., Veitch, S., Elder, P., Jain, M., Aries, J., Leak, S., Mitchell, E., Pavlu, J., Othman, J., Dillon, R., Mehta, P., Murthy, V., Knapper, S., Potter, V., Copland, M., Craddock, C., Krishnamurthy, P. (2025) Venetoclax-based non-intensive combinations for relapsed/refractory acute myeloid leukaemia: Real-world data from a UK-wide programme. British Journal of Haematology, 207, pp. 254-259. (doi: 10.1111/bjh.20149)

Cheng, C. et al. (2025) Targeting PIKfyve-driven lipid metabolism in pancreatic cancer. Nature, 642, pp. 776-784. (doi: 10.1038/s41586-025-08917-z)

Pfister, M., Ratti, F., Gores, G. J., Lesurtel, M., Chiche, L., Ebata, T., Ardiles, V., Valle, J. W., Heimbach, J. K., Braconi, C., Bruix, J., Aldrighetti, L., Clavien, P.-A. (2025) Recommendations on Perihilar Cholangiocarcinoma. The Milan Jury-Based Consensus. Annals of Surgery, (doi: 10.1097/sla.0000000000006773)

Saeed, R., McSorley, S., Cascales, A., McMillan, D. (2025) The prognostic/ predictive value of the systematic inflammatory response in patients receiving immunotherapy for non-small cell lung cancer: a systematic review and meta-analysis. BMC Cancer, 25, (doi: 10.1186/s12885-025-13822-9)

Castet, F. et al. (2025) Association of candidate surrogate endpoints with overall survival in advanced biliary tract cancer. Journal of Hepatology, (doi: 10.1016/j.jhep.2025.05.020)

McMahon, R., O'Cathail, S., Steele, C., Nair, H., Platt, J. J., McMillan, D. C., Horgan, P. G., Roxburgh, C.S.D. (2025) Circulating markers of systemic inflammation, measured after completion of neoadjuvant therapy, associated with response in locally advanced rectal cancer. Diseases of the Colon and Rectum, 68, pp. 713-725. (doi: 10.1097/DCR.0000000000003660)

Dreyer, S. B., Beer, P., Hingorani, S. R., Biankin, A. (2025) Improving outcomes of patients with pancreatic cancer. Nature Reviews Clinical Oncology, 22, pp. 439-456. (doi: 10.1038/s41571-025-01019-9)

Hurley, R., Paterson, C., Conway, D. I., Inman, G. J., Douglas, C. M. (2025) Laryngeal cancer in the West of Scotland 2014–2020: trends and survival in a cohort of 867 patients. Laryngoscope, 135, pp. 2051-2061. (doi: 10.1002/lary.31992)

Hall-Younger, E., Tait, S. W.G. (2025) Mitochondria and cell death signalling. Current Opinion in Cell Biology, 94, (doi: 10.1016/j.ceb.2025.102510)

Rovers, S., Farahmand, P., Liu, D., Brants, L., Hermans, C., Peeters, D., McKinven, D., Doig, J., Lardon, F., van Meerbeeck, J., Marcq, E., Murphy, D. J., Smits, E. (2025) A minimally invasive transthoracic injection technique for reproducible intrapleural delivery in mice. Methods and Protocols, 8, (doi: 10.3390/mps8030055)

Cartwright, D., Kidd, A. C., Ansel, S., Ascierto, M. L., Spiliopoulou, P. (2025) Oncogenic signalling pathways in cancer immunotherapy: leader or follower in this delicate dance? International Journal of Molecular Sciences, 26, (doi: 10.3390/ijms26094393)

Woraharn, W., McCulloch, A., Bigley, C., Hatthakarnkul, P., Pennel, K., Alexander, P., Van Wyk, H., Roseweir, A., Hay, J., Maka, N., Park, J., Jamieson, N. B., Edwards, J., Roxburgh, C. S.D. (2025) Investigation of three alternative histopathological scoring methods at the invasive tumour front in colorectal cancer. Journal of Pathology: Clinical Research, 11, (doi: 10.1002/2056-4538.70031)

Dehghani, P., Salehirozveh, M., Tajabadi, A., Yeung, C. C., Lam, M., Leung, H. Y., Roy, V. A.L. (2025) Next-gen point-of-care tool for ultra-sensitive detection of urinary spermine for prostate cancer diagnosis. ACS Sensors, 10, pp. 2640-2651. (doi: 10.1021/acssensors.4c03250)

Aalto, T. et al. (2025) The Terry Fox Research Institute Marathon of Hope Cancer Centres Network: a pan-Canadian precision oncology initiative. Cancer Cell, 43, pp. 587-592. (doi: 10.1016/j.ccell.2025.03.014)

Hartley, A., Galbraith, L. C.A., Shaw, R., Tibbo, A., Veeratterapillay, R., Wilson, L., Heer, R., Blyth, K., Leung, H., Ahmad, I. (2025) Loss of ARID1A accelerates prostate tumourigenesis with a proliferative collagen-poor phenotype through co-operation with AP1 subunit cFos. British Journal of Cancer, 132, pp. 502-512. (doi: 10.1038/s41416-025-02944-3)

Woolley, C. E., Domingo, E., Fernandez-Tajes, J., Pennel, K., Roxburgh, P., Edwards, J., Richman, S. D., Maughan, T. S., Kerr, D. J., Soriano, I., Tomlinson, I. P.M. (2025) Coevolution of atypical BRAF and KRAS mutations in colorectal tumorigenesis. Molecular Cancer Research, 23, pp. 300-312. (doi: 10.1158/1541-7786.mcr-24-0464)

Hurley, R., Osbourne, J., Inman, G. J., Conway, D. I., Paterson, C., Douglas, C. (2025) Pre-treatment serum prognostic scores and survival in curatively treated laryngeal cancer. Laryngoscope Investigative Otolaryngology, 10, (doi: 10.1002/lio2.70124)

Mathews, C., Nauman, A., Johnstone, M., Stoops, R., Tham, A., Parsons, E. C., Robb, K. A., Sloan, W., Lynch, G., Edwards, J., McSorley, S. T. (2025) Retrospective cohort study: scope for improvement - barriers to post-polypectomy surveillance in the integrated technologies for improved polyp surveillance cohort. Alimentary Pharmacology and Therapeutics, 61, pp. 1381-1386. (doi: 10.1111/apt.18514)

Zanuso, V., Rimassa, L., Braconi, C. (2025) The rapidly evolving landscape of HCC: Selecting the optimal systemic therapy. Hepatology, 81, pp. 1365-1386. (doi: 10.1097/HEP.0000000000000572)

Thompson, J. J., MacLeod, N., Will, S., O'Rourke, F., McGovern, J., Roxburgh, C., Edwards, J., Dolan, R. D., McMillan, D. C. (2025) The prognostic value of a laboratory cachexia score (LCAS) defined by LDH, CRP and albumin in patients with advanced lung cancer. BMC Cancer, 25, (doi: 10.1186/s12885-025-13426-3)

Wong, M. K., Boukhaled, G. M., Armstrong, E., Liu, R., Heirali, A. A., Yee, N. R., Tsang, J., Spiliopoulou, P., Schneeberger, P. H.H., Wang, B. X., Cochrane, K., Sherriff, K., Allen-Vercoe, E., Siu, L. L., Spreafico, A., Coburn, B. (2025) Microbial Ecosystem Therapeutics 4 (MET4) elicits treatment-specific IgG responses associated with changes in gut microbiota in immune checkpoint inhibitor recipients with advanced solid tumors. Journal for ImmunoTherapy of Cancer, 13, (doi: 10.1136/jitc-2024-010681)

Müller, M. et al. (2025) Human-correlated genetic models identify precision therapy for liver cancer. Nature, 639, pp. 754-764. (doi: 10.1038/s41586-025-08585-z)

Rimassa, L., Lamarca, A., O'Kane, G. M., Edeline, J., McNamara, M. G., Vogel, A., Fassan, M., Forner, A., Kendall, T., Adeva, J., Casadei-Gardini, A., Fornaro, L., Hollebecque, A., Lowery, M. A., Macarulla, T., Malka, D., Mariamidze, E., Niger, M., Ustav, A., Bridgewater, J., Macias, R. I. R., Braconi, C. (2025) New systemic treatment paradigms in advanced biliary tract cancer and variations in patient access across Europe. Lancet Regional Health - Europe, 50, (doi: 10.1016/j.lanepe.2024.101170)

Laing, A., Elmarghany, A., Alghaith, A. A., Gouma, A., Stevens, T., Winton, A., Cassels, J., Clarke, C. J., Schwab, C., Harrison, C. J., Gibson, B., Keeshan, K. (2025) Paediatric bone marrow mesenchymal stem cells support acute myeloid leukaemia cell survival and enhance chemoresistance via contact-independent mechanism. British Journal of Haematology, 206, pp. 858-863. (doi: 10.1111/bjh.19884)

Biesma, N.C., Graus, M.U.J.E., Cirkel, G.A., Besselink, M.G., de Groot, J.W.B., Groot Koerkamp, B., Herbschleb, K.H., Los, M., Verdonk, R.C., Wilmink, J.W., Cervantes, A., Valle, J.W., Valkenburg-van Iersel, L.B.J., Froeling, F.E.M., Molenaar, I.Q., Daamen, L.A., de Vos-Geelen, J., van Santvoort, H.C., Dutch Pancreatic Cancer Group, (2025) Perspectives of the medical oncologist regarding adjuvant chemotherapy for pancreatic cancer: An international expert survey and case vignette study. European Journal of Surgical Oncology, 51, (doi: 10.1016/j.ejso.2024.109544)

Samarakoon, Y., Yelland, T., Garcia-Gonzalez, E., Justo-Junior, A. d. S., Mahmood, M., Manoharan, A., Patterson, S., Serafin, V., Gammage, P. A., Marmiroli, S., Halsey, C., Ismail, S., Roberts, E. W. (2025) UNC119 regulates T-cell receptor signalling in primary T cells and T acute lymphocytic leukaemia. Life Science Alliance, 8, (doi: 10.26508/lsa.202403066)

White, S. E., Schwartze, T. A., Mukundan, A., Schoenherr, C., Singh, S. P., van Dinther, M., Cunningham, K. T., White, M. P. J., Campion, T., Pritchard, J., Hinck, C. S., ten Dijke, P., Inman, G. J., Maizels, R. M., Hinck, A. P. (2025) TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts. Nature Communications, 16, (doi: 10.1038/s41467-025-56954-z)

Rimassa, L., Khan, S., Groot Koerkamp, B., Roessler, S., Andersen, J. B., Raggi, C., Lleo, A., Nault, J.-C., Calderaro, J., Gabbi, C., Kather, J. N., Banales, J. M., Bargellini, I., Morement, H., Krawczyk, M., Farazi, P. A., Carpino, G., Avila, M. A., Saborowski, A., Cardinale, V., Braconi, C., Macias, R. I. R. (2025) Mapping the landscape of biliary tract cancer in Europe: challenges and controversies. Lancet Regional Health - Europe, 50, (doi: 10.1016/j.lanepe.2024.101171)

Dolan, R. D., Pennel, K., Thompson, J., McKenzie, M., Alexander, P., Richards, C., Black, D., Abbass, T., Maka, N., McGovern, J., Roseweir, A., McSorley, S. T., Horgan, P. G., Roxburgh, C., McMillan, D. C., Edwards, J. (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3, (doi: 10.1038/s44276-024-00119-w)

Alkarn, A., Stapleton, L. J., Eleftheriou, D., Stewart, L., Chalmers, G., Hamed, A., Hussein, K., Blyth, K. G., van der Hors, J. C., Maclay, J. D. (2025) Real life pre-operative nodal staging accuracy in non-small cell lung cancer and its relationship with survival. Diagnostics, 15, (doi: 10.3390/diagnostics15040430)

Pearson, L.-A., Petit, A.-P., Mendoza-Martinez, C., Bellany, F., Lin, D., Niven, S., Swift, R., Eadsforth, T., Fyfe, P. K., Paul, M., Postis, V., Hu, X., Cowling, V. H., Gray, D. W. (2025) Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach. Biochemical Journal, 482, pp. 209-224. (doi: 10.1042/bcj20240608)

Iwata, T., Ammar, A., Maka, N., Jawny, J., Hay, J., Martinelli, S., Officer-Jones, L., Le Quesne, J., Lynch, G., McSorley, S., Edwards, J. (2025) Does Immune Suppression in the Pre-malignant Microenvironment of Colorectal Neoplastic Lesions Associate with Development of Metachronous Polyp and Cancer Risk?

Kocher, H. M., Ackermann, C., Priyadarshini, G., Lawrence, C., Kotriwala, N., Georgescu, R., Roberts, R., Hughes, C., Imrali, A., Chelala, C., Dixon-Hughes, J., Chang, D. K., Sasieni, P., Corrie, P., McNamara, M. G., Sarker, D., Froeling, F. E.M., Christie, A., Gillmore, R., Khan, K., Propper, D. (2025) Study protocol: multi-centre, randomised controlled clinical trial exploring stromal targeting in locally advanced pancreatic cancer; STARPAC2. BMC Cancer, 25, (doi: 10.1186/s12885-024-13333-z)

Singh, S. P., Smyth, D. J., Cunningham, K. T., Mukundan, A., Byeon, C.-H., Hinck, C. S., White, M. P.J., Ciancia, C., Wąsowska, N., Sanders, A., Jin, R., White, R. F., Lilla, S., Zanivan, S., Schoenherr, C., Inman, G., van Dinther, M., ten Dijke, P., Hinck, A. P., Maizels, R. M. (2025) The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding. EMBO Reports, 26, pp. 218-244. (doi: 10.1038/s44319-024-00323-2)

Ibrahim, I., Kouli, O., Ilangovan, S., Sneddon, M., Nalagatla, S., Marshall, C., Dutto, L., Leung, H. Y., Ahmad, I. (2025) Impact of centralisation of radical prostatectomy driven by the introduction of robotic systems on positive surgical margin and biochemical recurrence in pT2 prostate cancer. Cancer Medicine, 14, (doi: 10.1002/cam4.70514)

Seyedshahi, F., Rakovic, K., Poulain, N., Claudio Quiros, A., Powley, I. R., Richards, C., Uraiby, H., Klebe, S., Moore, D. A., Nakas, A., Wilson, C. R., Sereno, M., Officer-Jones, L., Ficken, C., Teodosio, A., Ballantyne, F., Murphy, D., Yuan, K., Le Quesne, J. (2025) A histomorphological atlas of resected mesothelioma discovered by self-supervised learning from 3446 whole-slide images. Nature Communications, 16, (doi: 10.1038/s41467-025-63846-9)

Ingham, A. R., McSorley, S. T., McMillan, D. C., Chong, D., Mackay, G. J., Wrobel, A., Kong, C. Y., Alani, A., Nicholson, G., Roxburgh, C. S.D. (2025) Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections? Journal of Robotic Surgery, 19, (doi: 10.1007/s11701-025-02261-0)

Neilly, M. D.J., Dick, C., Blyth, K. G. (2025) Non-Specific Pleuritis: an update. Current Pulmonology Reports, 14, (doi: 10.1007/s13665-025-00371-6)

Liu, D., Young, F., Lamb, K., Claudio Quiros, A., Pancheva, A., Miller, C., Macdonald, C., Robertson, D. L., Yuan, K. (2025) PLM-interact: extending protein language models to predict protein-protein interactions. Nature Communications, 16, (doi: 10.1038/s41467-025-64512-w)

Seyedshahi, F., Rakovic, K., Poulain, N., Claudio Quiros, A., Powley, I. R., Richards, C., Uraiby, H., Klebe, S., Nakas, A., Wilson, C., Sereno, M., Officer-Jones, L., Ficken, C., Teodosio, A., Ballantyne, F., Murphy, D., Yuan, K., Le Quesne, J. (2024) A histomorphological atlas of resected mesothelioma discovered by self-supervised learning from 3446 whole-slide images. bioRxiv, (doi: 10.1101/2024.11.18.624103)

Maldonado, H., Dreger, M., Bedgood, L. D., Kyriakou, T., Wolanska, K. I., Rigby, M. E., Marotta, V. E., Webster, J. M., Wang, J., Rusilowicz-Jones, E. V., Marshall, J. F., Coulson, J. M., MacPherson, I. R., Hurlstone, A., Morgan, M. R. (2024) A trafficking regulatory subnetwork governs α V β 6 integrin-HER2 cross-talk to control breast cancer invasion and drug resistance. Science Advances, 10, (doi: 10.1126/sciadv.adk9944)

Apps, J., Halsey, C., Pritchard Jones, K., Atun, R., Shanmugavadivel, D., Oliver, K., Vedhara, K., Liu, J., Ball-Gamble, A., Ranasinghe, N., Polanco, A., Adamski, J., Green, A., Walker, D. A. (2024) A review calling for research directed at early detection of childhood cancers: the clinical, scientific, and economic arguments for population screening and surveillance. EJC Paediatric Oncology, 4, (doi: 10.1016/j.ejcped.2024.100191)

Shamis, S. A.K., Quinn, J., Al-Badran, S., McKenzie, M., Hatthakarnkul, P., Lynch, G., Lian, G.-Y., Numprasit, W., Romics Jr, L., Andersen, D., Mallon, E., McMillan, D. C., Edwards, J. (2024) Elucidation of dysregulated pathways associated with hypoxia in oestrogen receptor-negative breast cancer. Cancer Medicine, 13, (doi: 10.1002/cam4.70274)

Kiourtis, C. et al. (2024) Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nature Cell Biology, 26, pp. 2075-2083. (doi: 10.1038/s41556-024-01543-3)

Walker, M., Morton, J. P. (2024) Hydrogel models of pancreatic adenocarcinoma to study cell mechanosensing. Biophysical Reviews, 16, pp. 851-870. (doi: 10.1007/s12551-024-01265-8)

Pennel, K., Kurniawan, A., Al-Badran, S. S. F., Schubert Santana, L., Quinn, J., Nixon, C., Hatthakarnkul, P., Maka, N., Roxburgh, C., McMillan, D., Edwards, J. (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14, (doi: 10.3390/biom14121629)

Copland, A., Mackie, G. M., Scarfe, L., Jinks, E., Lecky, D. A.J., Gudgeon, N., McQuade, R., Ono, M., Barthel, M., Hardt, W.-D., Ohno, H., Hoevenaar, W. H.M., Dimeloe, S., Bending, D., Maslowski, K. M. (2024) Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity. EMBO Molecular Medicine, 16, pp. 3057-3088. (doi: 10.1038/s44321-024-00159-2)

Liu, D., Young, F., Lamb, K. D., Claudio Quiros, A., Pancheva, A., Miller, C., Macdonald, C., Robertson, D. L., Yuan, K. (2024) PLM-interact: extending protein language models to predict protein-protein interactions. bioRxiv, (doi: 10.1101/2024.11.05.622169)

Spear, S., Le Saux, O., Mirza, H. B., Iyer, N., Tyson, K., Grundland Freile, F., Walton, J. B., Woodman, C., Jarvis, S., Ennis, D. P., Aguirre Hernandez, C., Xu, Y., Spiliopoulou, P., Brenton, J. D., Costa-Pereira, A. P., Cook, D. P., Vanderhyden, B. C., Keun, H. C., Triantafyllou, E., Arnold, J. N., McNeish, I. A. (2024) PTEN loss shapes macrophage dynamics in high grade serous ovarian carcinoma. Cancer Research, 84, pp. 3772-3787. (doi: 10.1158/0008-5472.can-23-3890)

Xavier, V., Martinelli, S., Corbyn, R., Pennie, R., Rakovic, K., Powley, I. R., Officer-Jones, L., Ruscica, V., Galloway, A., Carlin, L. M., Cowling, V. H., Le Quesne, J., Martinou, J.-C., MacVicar, T. (2024) Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression. Life Science Alliance, 7, (doi: 10.26508/lsa.202402764)

Genta, S., Araujo, D.V., Hueniken, K., Pipinikas, C., Ventura, R., Rojas, P., Jones, G., Butler, M.O., Saibil, S.D., Yu, C., Easson, A., Covelli, A., Sauder, M.B., Fournier, C., Saeed Kamil, Z., Rogalla, P., Arteaga, D.P., Vornicova, O., Spiliopoulou, P., Muniz, T.P., Siu, L.L., Spreafico, A. (2024) Bespoke ctDNA for longitudinal detection of molecular residual disease in high-risk melanoma patients. ESMO Open, 9, (doi: 10.1016/j.esmoop.2024.103978)

Skalka, G. L., Whyte, D., Lubawska, D., Murphy, D. J. (2024) NUAK: never underestimate a kinase. Essays In Biochemistry, 68, pp. 295-307. (doi: 10.1042/EBC20240005)

Copland, M. (2024) Triplet therapy for advanced BCR::ABL1 positive myeloid leukaemias. Lancet Haematology, 11, pp. e807-e808. (doi: 10.1016/S2352-3026(24)00282-5)

Sahni, D. S., Morrison, J., Leung, H. Y. (2024) Grid-based cognitive diagnostic prostatic biopsies without transrectal ultrasound imaging. BJU International, 134, pp. 659-663. (doi: 10.1111/bju.16396)

Anastasopoulou, S., Swann, G., Andres-Jensen, L., Attarbaschi, A., Barzilai-Birenboim, S., Erdelyi, D. J., Escherich, G., Hamadeh, L., Harila, A., Lopez-Lopez, E., McGowan, S., Möricke, A., Putti, C., Sagi, J. C., Schmiegelow, K., Ullrich, N. J., van der Sluis, I. M., ul-Ain Wahid, Q., Winick, N., Sramkova, L., Zalcberg, Y., Zapotocka, E., Bhojwani, D., Halsey, C. (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, 205, pp. 1450-1459. (doi: 10.1111/bjh.19610)

Galbraith, N. J., Quinn, J. A., Al-Badran, S. S., Pennel, K. A.F., Hillson, L. V.S., Hatthakarnkul, P., McKenzie, M., Maka, N., Loi, L., Frixou, M., Steele, C. W., Roxburgh, C. S., Horgan, P. G., McMillan, D. C., Edwards, J. (2024) TAK1 expression is associated with increased PD-L1 and decreased cancer-specific survival in microsatellite-stable colorectal cancer. Translational Oncology, 48, (doi: 10.1016/j.tranon.2024.102064)

Smith, C. D.L., McMahon, A. D., Purkayastha, M., Creaney, G., Clements, K., Inman, G. J., Bhatti, L. A., Douglas, C. M., Paterson, C., Conway, D. I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020) BJC Reports, 2, (doi: 10.1038/s44276-024-00089-z)

Innes, A. I. et al. (2024) Impact of BCR::ABL1 single nucleotide variants on asciminib efficacy. Leukemia, 38, pp. 2443-2455. (doi: 10.1038/s41375-024-02411-7)

Strathearn, L. S., Spender, L. C., Schoenherr, C., Mason, S., Edwards, R., Blyth, K., Inman, G. (2024) C1orf106 (INAVA) is a SMAD3-dependent TGF-β target gene that promotes clonogenicity and correlates with poor prognosis in breast cancer. Cells, 13, (doi: 10.3390/cells13181530)

Churchhouse, A. M.D., Billard, C. V., Suzuki, T., Pohl, S. O.G., Donnelly, K., Nixon, C., Arends, M. J., Din, S., Kirkwood, K., Marques Junior, J., Von Kriegsheim, A., Coffelt, S. B., Myant, K. B. (2024) Loss of DOCK2 potentiates Inflammatory Bowel Disease-associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression. Oncogene, 43, pp. 3094-3107. (doi: 10.1038/s41388-024-03135-9)

Smith, C. D.L., McMahon, A. D., Lyall, D. M., Goulart, M., Inman, G., Ross, A., Gormley, M., Dudding, T., Macfarlane, G. J., Robinson, M., Richiardi, L., Serraino, D., Polesel, J., Canova, C., Ahrens, W., Healy, C. M., Lagiou, P., Holcatova, I., Alemany, L., Znoar, A., Waterboer, T., Brennan, P., Virani, S., Conway, D. I. (2024) Development and external validation of a head and neck cancer risk prediction model. Head and Neck, 46, pp. 2261-2273. (doi: 10.1002/hed.27834)

Glover, H. L., Schreiner, A., Dewson, G., Tait, S. W.G. (2024) Mitochondria and cell death. Nature Cell Biology, 26, pp. 1434-1446. (doi: 10.1038/s41556-024-01429-4)

Pea, A., He, X., Upstill-Goddard, R., Luchini, C., Schubert Santana, L. P., Dreyer, S., Duthie, F., Jamieson, N. B., McKay, C. J., Dickson, E. J., Pulvirenti, A., Rebus, S., Innovation Alliance, G., Genome Partnership, S., Piccoli, P., Sperandio, N., Lawlor, R. T., Milella, M., Froeling, F. E.M., Salvia, R., Scarpa, A., Bainkin, A. V., Wedge, D. C., Chang, D. K. (2024) Clonal evolutionary analysis reveals patterns of malignant transformation in pancreatic cancer from Intraductal Papillary Mucinous IPMN Neoplasms (IPMN) bioRxiv, (doi: 10.1101/2024.08.02.606217)

Lukoszek, R., Inesta-Vaquera, F., Brett, N. J.M., Liang, S., Hepburn, L. A., Hughes, D. J., Pirillo, C., Roberts, E. W., Cowling, V. H. (2024) CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection. Cell Reports, 43, (doi: 10.1016/j.celrep.2024.114405)

Wiesheu, R. et al. (2024) IL-27 maintains cytotoxic Ly6C+ T cells that arise from immature precursors. EMBO Journal, 43, pp. 2878-2907. (doi: 10.1038/s44318-024-00133-1)

Keith, N. et al. (2024) Emerging Ecologies of Health, Heritage, and Habitat: Looking into Living and Working in 2033. (doi: 10.17605/OSF.IO/BTNZ9)

Frankell, A. M. et al. (2024) Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature, 631, (doi: 10.1038/s41586-024-07738-w)

Pereira, B. A. et al. (2024) Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response. Science Advances, 10, (doi: 10.1126/sciadv.adl1197)

Knight, K., Bigley, C., Pennel, K., Hay, J., Maka, N., McMillan, D., Park, J., Roxburgh, C., Edwards, J. (2024) The Glasgow Microenvironment Score: an exemplar of contemporary biomarker evolution in colorectal cancer. Journal of Pathology: Clinical Research, 10, (doi: 10.1002/2056-4538.12385)

Vincelette, N. D. et al. (2024) Trisomy 8 defines a distinct subtype of myeloproliferative neoplasms driven by the MYC-alarmin axis. Blood Cancer Discovery, 5, pp. 276-297. (doi: 10.1158/2643-3230.BCD-23-0210)

Sumaria, N., Fiala, G. J., Inácio, D., Curado-Avelar, M., Cachucho, A., Pinheiro, R., Wiesheu, R., Kimura, S., Courtois, L., Blankenhaus, B., Darrigues, J., Suske, T., Almeida, A. R. M., Minguet, S., Asnafi, V., Lhermitte, L., Mullighan, C. G., Coffelt, S. B., Moriggl, R., Barata, J. T., Pennington, D. J., Silva-Santos, B. (2024) Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R-STAT5B-driven neoplasms. Nature Immunology, 25, pp. 1207-1217. (doi: 10.1038/s41590-024-01855-4)

Thompson, J., McGovern, J., Roxburgh, C., Edwards, J., Dolan, R. D., McMillan, D. C. (2024) The relationship between LDH and GLIM criteria for cancer cachexia: systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 199, (doi: 10.1016/j.critrevonc.2024.104378)

McKenzie, M., Lian, G.-Y., Pennel, K. A.F., Quinn, J. A., Jamieson, N. B., Edwards, J. (2024) NFκB signalling in colorectal cancer: examining the central dogma of IKKα and IKKβ signalling. Heliyon, 10, (doi: 10.1016/j.heliyon.2024.e32904)

Hanna, D. et al. (2024) Real world study of sacituzumab govitecan in metastatic triple-negative breast cancer in the United Kingdom. British Journal of Cancer, 130, pp. 1916-1920. (doi: 10.1038/s41416-024-02685-9)

Domingo, E. et al. (2024) Prognostic and predictive value of Immunoscore in stage III colorectal cancer: pooled analysis of 2,608 cases from the SCOT and IDEA-HORG studies. Journal of Clinical Oncology, 42, pp. 2207-2218. (doi: 10.1200/JCO.23.01648)

Khalaf, A., de Beauchamp, L., Kalkman, E., Rattigan, K., Himonas, E., Jones, J., James, D., Shokry, E. S. A., Scott, M. T., Dunn, K., Tardito, S., Copland, M., Sumpton, D., Shanks, E., Helgason, V. (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16, (doi: 10.1126/scitranslmed.adi5336)

Shiu, K.-K., Jiang, Y., Saunders, M., Seligmann, J. F., Iveson, T., Wilson, R. H., Graham, J. S., Khan, K. H., Militello, A.-M., Irvine, S., Adedoyin, T., Begum, R., Bhat, R., Wilson, W., Plumb, A., Obichere, A., Rodriguez-Justo, M., Jansen, M. (2024) NEOPRISM-CRC: Neoadjuvant pembrolizumab stratified to tumour mutation burden for high risk stage 2 or stage 3 deficient-MMR/MSI-high colorectal cancer. (doi: 10.1200/jco.2024.42.17_suppl.lba3504)

Kumar, S., Basto, A. P., Ribeiro, F., Almeida, S. C.P., Campos, P., Peres, C., Pulvirenti, N., Al-Khalidi, S., Kilbey, A., Tosello, J., Piaggio, E., Russo, M., Gama-Carvalho, M., Coffelt, S. B., Roberts, E. W., Geginat, J., Florindo, H. F., Graca, L. (2024) Specialized Tfh cell subsets driving type-1 and type-21 humoral responses in lymphoid tissue. Cell Discovery, 10, (doi: 10.1038/s41421-024-00681-0)

Malla, S. B. et al. (2024) Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56, (doi: 10.1038/s41588-024-01809-4)

Manchanda, R. et al. (2024) Cost-effectiveness of unselected multigene germline and somatic genetic testing for epithelial ovarian cancer. Journal of the National Comprehensive Cancer Network, 22, (doi: 10.6004/jnccn.2023.7331)

Blyth, K. G., Adusumilli, P. S., Astoul, P., Darlison, L., Lee, Y.C. G., Mansfield, A. S., Marciniak, S. J., Maskell, N., Panou, V., Peikert, T., Rahman, N. M., Zauderer, M. G., Sterman, D., Fennell, D. A. (2024) Leveraging the pleural space for anticancer therapies in pleural mesothelioma. Lancet Respiratory Medicine, 12, pp. 476-483. (doi: 10.1016/S2213-2600(24)00111-5)

Hillson, L. V. S., McCulloch, A. K., Edwards, J., Dunne, P. D., O'Cathail, S. M., Roxburgh, C. S. (2024) Radiation-induced changes in gene expression in rectal cancer specimens. Clinical and Translational Oncology, 26, pp. 1419-1428. (doi: 10.1007/s12094-023-03361-9)

Kendall, T., Overi, D., Guido, M., Braconi, C., Banales, J., Cardinale, V., Gaudio, E., Groot Koerkamp, B., Carpino, G. (2024) Recommendations on maximising the clinical value of tissue in the management of patients with intrahepatic cholangiocarcinoma. JHEP Reports, 6, (doi: 10.1016/j.jhepr.2024.101067)

Agnew, S., Crawford, M., MacPherson, I., Shiramizu, V., Fleming, L. (2024) The impact of symptom clusters on endocrine therapy adherence in patients with breast cancer. Breast, 75, (doi: 10.1016/j.breast.2024.103731)

Zanuso, V., Nash, T., Casolino, R., Armstrong, G., Pallise, O., Milne, J., Braconi, C. (2024) Insights for clinical management from the real-life data of the centralized West of Scotland biliary cancer clinic. BMC Cancer, 24, (doi: 10.1186/s12885-024-12279-6)

Boey, A., Bryce, A., Dickson, E., Coats, M., McKay, C., Jamieson, N., Chang, D., Holroyd, D., Dreyer, S. (2024) The Impact of Pre-operative Indeterminate Lung Nodules in the Surgical Management of Pancreatic Ductal Adenocarcinoma. (doi: 10.1016/j.hpb.2024.03.269)

Astuti, Y., Raymant, M., Quaranta, V., Clarke, K., Abudula, M., Smith, O., Bellomo, G., Chandran-Gorner, V., Nourse, C., Halloran, C., Ghaneh, P., Palmer, D., Jones, R. P., Campbell, F., Pollard, J. W., Morton, J. P., Mielgo, A., Schmid, M. C. (2024) Author correction: Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5, (doi: 10.1038/s43018-024-00751-y)

Mardilovich, K., Naylor, G., Julian, L., Phinichkusolchit, N., Keeshan, K., Blyth, K., Olson, M. F. (2024) Caspase-resistant ROCK1 expression prolongs survival of Eµ-Myc B cell lymphoma mice. Disease Models and Mechanisms, 17, (doi: 10.1242/dmm.050631)

Astuti, Y., Raymant, M., Quaranta, V., Clarke, K., Abudula, M., Smith, O., Bellomo, G., Chandran-Gorner, V., Nourse, C., Halloran, C., Ghaneh, P., Palmer, D., Jones, R. P., Campbell, F., Pollard, J. W., Morton, J. P., Mielgo, A., Schmid, M. C. (2024) Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5, pp. 774-790. (doi: 10.1038/s43018-024-00731-2)

Hatthakarnkul, P., Pennel, K., Alexander, P., Van Wyk, H., Roseweir, A., Inthagard, J., Hay, J., Andersen, D., Maka, N., Park, J., Roxburgh, C., Thuwajit, C., McMillan, D., Edwards, J. (2024) Histopathological tumour microenvironment score independently predicts outcome in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 10, (doi: 10.1002/2056-4538.12374)

Ahmed Hassan Elshiekh, A., Tait, S. W.G. (2024) Tumour immunogenicity goes with the (mitochondrial electron) flow. Molecular Oncology, 18, pp. 1054-1057. (doi: 10.1002/1878-0261.13627)

Raymant, M., Astuti, Y., Alvaro-Espinosa, L., Green, D., Quaranta, V., Bellomo, G., Glenn, M., Chandran-Gorner, V., Palmer, D. H., Halloran, C., Ghaneh, P., Henderson, N. C., Morton, J. P., Valiente, M., Mielgo, A., Schmid, M. C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15, (doi: 10.1038/s41467-024-47949-3)

Neilly, M., Ferguson, K., Roche, J., Tate, M., Blyth, K. (2024) Mesothelioma Evolution following a Diagnosis of Benign Pleural Inflammation: A Systematic Review and Meta-Analysis. (doi: 10.1016/j.lungcan.2024.107626)

Pennel, K., Dutton, L., Melissourgou-Syka, L., Roxburgh, C., Birch, J., Edwards, J. (2024) Novel radiation and targeted therapy combinations for improving rectal cancer outcomes. Expert Reviews in Molecular Medicine, 26, (doi: 10.1017/erm.2024.15)

Glen, C., Morrow, A., Roditi, G., Hopkins, T., Macpherson, I., Stewart, P., Petrie, M. C., Berry, C., Epstein, F., Lang, N. N., Mangion, K. (2024) Cardiovascular sequalae of trastuzumab and anthracycline in long-term survivors of breast cancer. Heart, 110, pp. 650-656. (doi: 10.1136/heartjnl-2023-323437)

Murphy, D. J. (2024) Investigating lung cancer using genetically engineered mouse models (GEMMS) Open Access Government, 42, pp. 112-113. (doi: 10.56367/oag-042-11090)

Brown, L. R., Thomson, G. G., Gardner, E., Chien, S., McGovern, J., Dolan, R. D., McSorley, S. T., Forshaw, M. J., McMillan, D. C., Wigmore, S. J., Crumley, A., Skipworth, R. J.E. (2024) Cachexia index for prognostication in surgical patients with locally advanced oesophageal or gastric cancer: multicentre cohort study. British Journal of Surgery, 111, (doi: 10.1093/bjs/znae098)

Lupo, F., Coffelt, S. B. (2024) Stressed out neutrophils drive metastasis. Immunity, 57, pp. 840-842. (doi: 10.1016/j.immuni.2024.03.013)

Spiliopoulou, P., Kazmi, F., Aroldi, F., Holmes, T., Thompson, D., Griffiths, L., Qi, C., Parkes, M., Lord, S., Veal, G. J., Harrison, D. J., Coyle, V. M., Graham, J., Jeffry Evans, T. R., Blagden, S. P. (2024) A phase I open-label, dose-escalation study of NUC-3373, a targeted thymidylate synthase inhibitor, in patients with advanced cancer (NuTide:301) Journal of Experimental and Clinical Cancer Research, 43, (doi: 10.1186/s13046-024-03010-1)

Derby, S. et al. (2024) Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis. Neuro-Oncology, 26, pp. 625-639. (doi: 10.1093/neuonc/noad210)

Dehghani, P., Karthikeyan, V., Tajabadi, A., Assi, D. S., Catchpole, A., Wadsworth, J., Leung, H. Y., Roy, V. A.L. (2024) Rapid near-patient impedimetric sensing platform for prostate cancer diagnosis. ACS Omega, 9, pp. 14580-14591. (doi: 10.1021/acsomega.4c00843)

Ingham,, A. R., Kong, C. Y., Wong, T.-N., McSorley, S. T., McMillan, D. C., Nicholson, G. A., Alani, A., Mansouri, D., Chong, D., Mackay, G. J., Roxburgh, C. S.D. (2024) Robotic-assisted surgery for left sided colon and rectal resections is associated with reduction in the postoperative surgical stress response and improved short-term outcomes: a cohort study. Surgical Endoscopy, (doi: 10.1007/s00464-024-10749-3)

Dickson, A. L., Zickuhr, G. M., Um, I. H., Zhang, Y., Plummer, R., Blagden, S. P., Symeonides, S. N., Cook, N., Evans, T.R. J., Elshani, M., Harrison, D. J. (2024) Exposing the heterogeneity of the lipidome in the TME of cutaneous melanoma following treatment with NUC-7738 in combination with anti-PD-1 therapy. (doi: 10.1158/1538-7445.am2024-6222)

Tesson, M., Stevenson, K., Karim, S. A., Nixon, C., Chalmers, A. J., Sansom, O. J., O'Neill, E., Jones, K., Morton, J. P. (2024) Targeted irradiation in an autochthonous mouse model of pancreatic cancer. Disease Models and Mechanisms, 17, (doi: 10.1242/dmm.050463)

Hassan, M., Touman, A. A., Grabczak, E. M., Skaarup, S. H., Faber, K., Blyth, K. G., Pochepnia, S. (2024) Imaging of pleural disease. Breathe, 20, (doi: 10.1183/20734735.0172-2023)

Sacco, J. J., Jackson, R., Corrie, P., Danson, S., Evans, J., Ochsenreither, S., Kumar, S., Goodman, A., Larkin, J., Karydis, I., Steven, N., Lorigan, P., Plummer, R., Patel, P., Psarelli, E., Olsson-Brown, A., Shaw, H., Leyvraz, S., Handley, L., Rawcliffe, C., Nathan, P. (2024) A three-arm randomised phase II study of the MEK inhibitor selumetinib alone or in combination with paclitaxel in metastatic uveal melanoma. European Journal of Cancer, 202, (doi: 10.1016/j.ejca.2024.114009)

Zarou, M. M., Rattigan, K. M., Sarnello, D., Shokry, E., Dawson, A., Ianniciello, A., Dunn, K., Copland, M., Sumpton, D., Vazquez, A., Helgason, V. (2024) Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1-mediated purine sensing. Nature Communications, 15, (doi: 10.1038/s41467-024-46114-0)

Leung, E. Y.l., Athineos, D., Al-Khalidi, S. K., Cole, J., Woolcock, K., Pingen, M., Bartolini, R., Medina-Ruiz, L., Burgoyne, P., Bryson, G., Canning, R., Nixon, C., Hughes, C., Hohne, R., Coffelt, S., Ennis, D., Blyth, K., Mcneish, I., Roberts, E., Graham, G. (2024) Chemokine CCL21 Induces an Immunotolerant Tumour Microenvironment Leading to Poorer Survival in Ovarian Cancer. (doi: 10.1136/ijgc-2024-esgo.985)

Lee, C. L., O'Kane, G. M., Mason, W. P., Zhang, W.-J., Spiliopoulou, P., Hansen, A. R., Grant, R. C., Knox, J. J., Stockley, T. L., Zadeh, G., Chen, E. X. (2024) Circulating oncometabolite 2-hydroxyglutarate (2HG) as a potential biomarker for isocitrate dehydrogenase (IDH1/2) mutant cholangiocarcinoma. Molecular Cancer Therapeutics, 23, pp. 394-399. (doi: 10.1158/1535-7163.mct-23-0460)

Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, (doi: 10.1186/s13046-024-02958-4)

Tárnoki, Á. D., Tárnoki, D. L., Dąbrowska, M., Knetki-Wróblewska, M., Frille, A., Stubbs, H., Blyth, K. G., Juul, A. D. (2024) New developments in the imaging of lung cancer. Breathe, 20, (doi: 10.1183/20734735.0176-2023)

Copland, M., Ariti, C., Thomas, I. F., Upton, L., Sydenham, M., Mehta, P., Islam, S., Kjeldsen, L., Burnett, A. K., Hills, R. K., Russell, N., Dennis, M. (2024) A randomised evaluation of low-dose cytosine arabinoside plus lenalidomide versus single-agent low-dose cytosine arabinoside in older patients with acute myeloid leukaemia: Results from the LI-1 trial. British Journal of Haematology, 204, (doi: 10.1111/bjh.19220)

O’Rourke, C. J. et al. (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73, pp. 496-508. (doi: 10.1136/gutjnl-2023-330748)

Malla, S. B. et al. (2024) Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56, pp. 458-472. (doi: 10.1038/s41588-024-01654-5)

Morrow, A. J. et al. (2024) Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization. Communications Medicine, 4, (doi: 10.1038/s43856-024-00455-5)

Bryce, A., Dreyer, S., Dolan, R., Froeling, F., Chang, D. (2024) Host phenotypic adversity independently predicts progression to resection in neoadjuvantly-treated pancreatic cancer. (doi: 10.1016/j.ejso.2023.107753)

Dreyer, S., Bryce, A., Australian Pancreatic Cancer Genome Initiative, , Biankin, A., Jamieson, N., Chang, D. (2024) The clinical and molecular landscape of early onset pancreatic cancer. (doi: 10.1016/j.ejso.2023.107348)

Coakley, M., Villacampa, G., Sritharan, P., Swift, C., Dunne, K., Kilburn, L., Goddard, K., Pipinikas, C., Rojas, P., Emmett, W., Hall, P., Harper-Wynne, C., Hickish, T., MacPherson, I., Okines, A., Wardley, A., Wheatley, D., Waters, S., Palmieri, C., Winter, M., Cutts, R. J., Garcia-Murillas, I., Bliss, J., Turner, N. C. (2024) Comparison of circulating tumor DNA assays for Molecular Residual Disease detection in early-stage triple negative breast cancer. Clinical Cancer Research, 30, pp. 895-903. (doi: 10.1158/1078-0432.CCR-23-2326)

Vringer, E., Heilig, R., Riley, J. S., Black, A., Cloix, C., Skalka, G., Montes-Gómez, A. E., Aguado, A., Lilla, S., Walczak, H., Gyrd-Hansen, M., Murphy, D. J., Huang, D. T., Zanivan, S., Tait, S. W.G. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43, pp. 904-930. (doi: 10.1038/s44318-024-00044-1)

Dawson, A. et al. (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15, (doi: 10.1038/s41467-024-45471-0)

Kingston, B., Pearson, A., Herrera-Abreu, M. T., Sim, L.-X., Cutts, R. J., Shah, H., Moretti, L., Kilburn, L. S., Johnson, H., Macpherson, I. R., Ring, A., Bliss, J. M., Hou, Y., Toy, W., Katzenellenbogen, J. A., Chandarlapaty, S., Turner, N. C. (2024) ESR1 F404 mutations and acquired resistance to fulvestrant in ESR1 mutant breast cancer. Cancer Discovery, 14, pp. 274-289. (doi: 10.1158/2159-8290.CD-22-1387)

Fetit, R., McLaren, A. S., White, M., Mills, M. L., Falconer, J., Cortes-Lavaud, X., Gilroy, K., Lannagan, T. R.M., Ridgway, R. A., Nixon, C., Naiker, V., Njunge, R., Clarke, C., Whyte, D., Kirschner, K., Jackstadt, R., Norman, J., Carlin, L. M., Campbell, A. D., Sansom, O. J., Steele, C. W. (2024) Characterising neutrophil subtypes in cancer using scRNA sequencing demonstrates the importance of IL-1β/CXCR2 axis in generation of metastasis specific neutrophils. Cancer Research Communications, 4, pp. 588-606. (doi: 10.1158/2767-9764.CRC-23-0319)

Frei, A. L. et al. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25, pp. 198-211. (doi: 10.1016/S1470-2045(23)00560-0)

Skalka, G. L., Tsakovska, M., Murphy, D. (2024) Kinase signaling adaptation supports dysfunctional mitochondria in disease. Frontiers in Molecular Biosciences, 11, (doi: 10.3389/fmolb.2024.1354682)

Scott, M. T., Liu, W., Mitchell, R., Clarke, C. J., Kinstrie, R., Warren, F., Almasoudi, H., Stevens, T., Dunn, K., Pritchard, J., Drotar, M. E., Michie, A. M., Jorgensen, H. G., Higgins, B., Copland, M., Vetrie, D. (2024) Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease. Nature Communications, 15, (doi: 10.1038/s41467-024-44771-9)

Spiliopoulou, P., Kaur, P., Hammett, T., Di Conza, G., Lahn, M. (2024) Targeting T regulatory (Treg) cells in immunotherapy-resistant cancers. Cancer Drug Resistance, 7, (doi: 10.20517/cdr.2023.46)

Catarata, M. J., Creamer, A. W., Dias, M., Toland, S., Chaabouni, M., Verbeke, K., Vieira Naia, J., Hassan, M., Naidu, S. B., Lynch, G. A., Blyth, K. G., Rahman, N. M., Hardavella, G. (2024) ERS International Congress 2023: highlights from the Thoracic Oncology Assembly. ERJ Open Research, 10, (doi: 10.1183/23120541.00860-2023)

Spiliopoulou, P., Lopes, C. D. H., Spreafico, A. (2024) Promising and minimally invasive biomarkers: targeting melanoma. Cells, 13, (doi: 10.3390/cells13010019)

Shamis, S. A. K., Savioli, F., Ammar, A., Al-Badran, S. S.F., Hatthakarnkul, P., Leslie, H., Mallon, E., Jamieson, N. B., McMillan, D. C., Edwards, J. (2024) Spatial transcriptomic analysis of tumour with high and low CAIX expression in TNBC tissue samples using GeoMx™ RNA assay. Histology and Histopathology: Cellular and Molecular Biology, 39, pp. 177-200. (doi: 10.14670/HH-18-655)

Brouwer, N.P.M., Khan, A., Bokhorst, J.M., Ayatollahi, F., Hay, J., Ciompi, F., Simmer, F., Hugen, N., de Wilt, J.H.W., Berger, M.D., Lugli, A., Zlobec, I., Edwards, J., Nagtegaal, I.D. (2024) The complexity of shapes: how the circularity of tumor nodules impacts prognosis in colorectal cancer. Modern Pathology, 37, (doi: 10.1016/j.modpat.2023.100376)

Johnstone, M. S., McSorley, S. T., McMillan, D. C., Horgan, P. G., Mansouri, D. (2024) The relationship between systemic inflammatory response, screen detection and outcome in colorectal cancer. Colorectal Disease, 26, pp. 81-94. (doi: 10.1111/codi.16824)

Knop, K., Gomez-Moreira, C., Galloway, A., Ditsova, D., Cowling, V. H. (2024) RAM is upregulated during T cell activation and is required for RNA cap formation and gene expression. Discovery Immunology, 3, (doi: 10.1093/discim/kyad021)

Kidd, A. C., Cowell, G. W., Martin, G. A., Ferguson, J., Fennell, D. A., Evison, M., Blyth, K. G. (2024) The prevalence and prognostic significance of sarcopenia and adipopenia in pleural mesothelioma. Cancer Treatment and Research Communications, 42, (doi: 10.1016/j.ctarc.2024.100856)

Wang, J., Harwood, C. A., Bailey, E., Bewicke-Copley, F., Anene, C. A., Thomson, J., Qamar, M. J., Laban, R., Nourse, C., Schoenherr, C., Treanor-Taylor, M., Healy, E., Lai, C., Craig, P., Moyes, C., Rickaby, W., Martin, J., Proby, C., Inman, G. J., Leigh, I. M. (2023) Transcriptomic analysis of cutaneous squamous cell carcinoma reveals a multigene prognostic signature associated with metastasis. Journal of the American Academy of Dermatology, 89, pp. 1159-1166. (doi: 10.1016/j.jaad.2023.08.012)

Beach, C. et al. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133, (doi: 10.1172/JCI168277)

Ring, A., Kilburn, L. S., Pearson, A., Moretti, L., Afshari-Mehr, A., Wardley, A. M., Gurel, B., MacPherson, I. R., Riisnaes, R., Baird, R. D., Martin, S., Roylance, R., Johnson, H., Ferreira, A., Winter, M. C., Dunne, K., Copson, E., Hickish, T., Burcombe, R., Randle, K., Serra, V., Llop-Guevara, A., Bliss, J. M., Turner, N. C. (2023) Olaparib and celarasertib (AZD6738) in patients with triple negative advanced breast cancer: results from Cohort E of the plasmaMATCH trial (CRUK/15/010) Clinical Cancer Research, 29, pp. 4751-4759. (doi: 10.1158/1078-0432.CCR-23-1696)

Janse van Rensburg, H. J., Spiliopoulou, P., Makhzoum, A., Healy, B. D. (2023) Remitting seronegative symmetrical synovitis with pitting edema: a case report of an immune-related adverse event following surgery. Case Reports in Oncology, 16, pp. 662-669. (doi: 10.1159/000532004)

Berry, C. et al. (2023) Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study. Heart and Mind, 7, pp. 235-245. (doi: 10.4103/hm.HM-D-23-00037)

Ferguson, J., Tsim, S., Kelly, C., Alexander, L., Shad, S., Neilly, M., Tate, M., Zahra, B., Saleh, M., Cowell, G., Banks, E., Grundy, S., Corcoran, J., Downer, N., Stanton, A., Evison, M., Rahman, N., Maskell, N., Blyth, K. (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10, (doi: 10.1136/bmjresp-2023-001771)

Henriksen, P. A. et al. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148, pp. 1680-1690. (doi: 10.1161/CIRCULATIONAHA.123.064274)

McLaren, A. S., Spoor, J. A., Cartwright, D., Naylor, G., Barclay, S., Priest, M., Puttagunta, S., Armstrong, K., Ballantyne, S., Stanley, A., Evans, T. R. J., West of Scotland HCC MDT, (2023) Impact of the COVID-19 pandemic on patients with hepatocellular carcinoma in the west of Scotland: a cohort study. BMJ Open Gastroenterology, 10, (doi: 10.1136/bmjgast-2023-001231)

Chrisochoidou, Y., Roy, R., Farahmand, P., Gonzalez, G., Doig, J., Krasny, L., Rimmer, E. F., Willis, A. E., MacFarlane, M., Huang, P. H., Carragher, N. O., Munro, A. F., Murphy, D. J., Veselkov, K., Seckl, M. J., Moffatt, M. F., Cookson, W. O. C., Pardo, O. E. (2023) Crosstalk with lung fibroblasts shapes the growth and therapeutic response of mesothelioma cells. Cell Death and Disease, 14, (doi: 10.1038/s41419-023-06240-x)

Zarou, M. M., Dawson, A., Prasad, B., Bittencourt-Silvestre, J., Zerbst, D., Rodriguez Blanco, G., Scott, M., Dunn, K., Krishnan, V., Copland, M., Vetrie, D., Bhatia, R., Coffelt, S., Ong, S. T., Wheadon, H., Zanivan, S., Kirschner, K., Helgason, G. V. (2023) Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche. (doi: 10.1182/blood-2023-181630)

Taggart, R., Dutto, L., Leung, H. Y., Salji, M., Ahmad, I. (2023) A contemporary analysis of disease upstaging of Gleason 3+3 prostate cancer patients after Robot-Assisted Laparoscopic Prostatectomy (RALP) Cancer Medicine, 12, pp. 20830-20837. (doi: 10.1002/cam4.6651)

Frei, A. L. et al. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9, pp. 449-463. (doi: 10.1002/cjp2.342)

Galbraith, N. J., McCollum, C., Di Mascio, L., Lowrie, J., Hinckley, M., Lo, S., Watson, S., Telfer, J. R.C., Roxburgh, C. S., Horgan, P. S., Chong, P. S., Quinn, M., Steele, C. W. (2023) Effect of differing flap reconstruction strategies in perineal closure following advanced pelvic oncological resection: a retrospective cohort study. International Journal of Surgery, 109, pp. 3375-3382. (doi: 10.1097/JS9.0000000000000617)

Bergamini, A., Ramaswami, R., Froeling, F., Papanastasopoulos, P., Short, D., Aguiar, X., Savage, P. M., Sarwar, N., Kaur, B., Saso, S., Fotopoulou, C., Sharma, A., Rustin, G. J. S., Seckl, M. (2023) Fertility outcomes following surgery and multiagent chemotherapy in malignant ovarian germ cell tumor survivors: a survey study. International Journal of Gynecological Cancer, 33, pp. 1750-1756. (doi: 10.1136/ijgc-2023-004699)

Genta, S., Lajkosz, K., Yee, N. R., Spiliopoulou, P., Heirali, A., Hansen, A. R., Siu, L. L., Saibil, S., Stayner, L.-A., Yanekina, M., Sauder, M. B., Keshavarzi, S., Salawu, A., Vornicova, O., Butler, M. O., Bedard, P. L., Razak, A. R. A., Rottapel, R., Chruscinski, A., Coburn, B., Spreafico, A. (2023) Autoimmune PaneLs as PrEdictors of Toxicity in Patients TReated with Immune Checkpoint InhibiTors (ALERT) Journal of Experimental and Clinical Cancer Research, 42, (doi: 10.1186/s13046-023-02851-6)

Victorelli, S. et al. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622, pp. 627-636. (doi: 10.1038/s41586-023-06621-4)

Rattigan, K. M., Zarou, M. M., Brabcova, Z., Prasad, B., Zerbst, D., Sarnello, D., Kalkman, E. R., Ianniciello, A., Scott, M. T., Dunn, K., Shokry, E., Sumpton, D., Copland, M., Tardito, S., Vande Voorde, J., Mussai, F., Cheng, P., Helgason, G. V. (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24, (doi: 10.15252/embr.202256279)

Fisch, D., Pfleiderer, M. M., Anastasakou, E., Mackie, G. M., Wendt, F., Liu, X., Clough, B., Lara-Reyna, S., Encheva, V., Snijders, A. P., Bando, H., Yamamoto, M., Beggs, A. D., Mercer, J., Shenoy, A. R., Wollscheid, B., Maslowski, K. M., Galej, W. P., Frickel, E.-M. (2023) PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection. Science, 382, (doi: 10.1126/science.adg2253)

Johnstone, M. S., McSorley, S. T., McMahon, A. J. (2023) Management of malignant T1 colorectal cancer polyps: results from a 10-year prospective observational study. Colorectal Disease, 25, pp. 1960-1972. (doi: 10.1111/codi.16716)

Palmieri, C., Musson, A., Harper-Wynne, C., Wheatley, D., Bertelli, G., Macpherson, I. R., Nathan, M., McDowall, E., Bhojwani, A., Verrill, M., Eva, J., Doody, C., Chowdhury, R. (2023) A real-world study of the first use of palbociclib for the treatment of advanced breast cancer within the UK National Health Service as part of the novel Ibrance® Patient Program. British Journal of Cancer, 129, pp. 852-860. (doi: 10.1038/s41416-023-02352-5)

Nikolatou, K., Sandilands, E., Román-Fernández, A., Cumming, E. M., Freckmann, E., Lilla, S., Buetow, L., McGarry, L., Neilson, M., Shaw, R., Strachan, D., Miller, C., Huang, D. T., Mcneish, I. A., Norman, J. C., Zanivan, S., Bryant, D. M. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, (doi: 10.15252/embj.2023113987)

McMahon, R. K., O'Cathail, S. M., Nair, H., Steele, C. W., Platt, J. J., Digby, M., McDonald, A. C., Horgan, P. G., Roxburgh, C. S.D. (2023) The neoadjuvant rectal score and a novel magnetic resonance imaging based neoadjuvant rectal score are stage independent predictors of long-term outcome in locally advanced rectal cancer. Colorectal Disease, 25, pp. 1783-1794. (doi: 10.1111/codi.16667)

Quintana, J. F., Sinton, M. C., Chandrasegaran, P., Lestari, A. N., Heslop, R., Cheaib, B., Ogunsola, J., Ngoyi, D. M., Swar, N.-R. K., Cooper, A., Mabbott, N. A., Coffelt, S. B., MacLeod, A. (2023) γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection. Nature Communications, 14, (doi: 10.1038/s41467-023-40962-y)

Bailey, P., Ridgway, R. L., Cammareri, P., Treanor-Taylor, M., Bailey, U.-M., Schoenherr, C., Bone, M., Schreyer, D., Purdie, K., Thomson, J., Rickaby, W., Jackstadt, R., Campbell, A. D., Dimonitsas, E., Stratigos, A. J., Arron, S. T., Wang, J., Blyth, K., Proby, C. M., Harwood, C. A., Sansom, O. J., Leigh, I. M., Inman, G. J. (2023) Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression. Nature Communications, 14, (doi: 10.1038/s41467-023-40822-9)

Rattigan, K. M., Brabcova, Z., Sarnello, D., Zarou, M. M., Roy, K., Kwan, R., de Beauchamp, L., Dawson, A., Ianniciello, A., Khalaf, A., Kalkman, E. R., Scott, M. T., Dunn, K., Sumpton, D., Michie, A. M., Copland, M., Tardito, S., Gottlieb, E., Helgason, G. V. (2023) Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells. Nature Communications, 14, (doi: 10.1038/s41467-023-40222-z)

Ferguson, K., Neilson, M., Mercer, R., King, J., Marshall, K., Welch, H., Tsim, S., Rahman, N. M., Maskell, N. A., Evison, M., Blyth, K. G. (2023) Results of the Meso-ORIGINS feasibility study regarding collection of matched benign-mesothelioma tissue pairs by longitudinal surveillance. BMJ Open, 13, (doi: 10.1136/bmjopen-2022-067780)

Mohamed, N. E., Amirkhah, R., Lavaud, X.-C., Gilroy, K., Bartolini, R., Mulholland, E. J., Garg, A. D., Pennel, K., Jackstadt, R., Ridgway, R. A., Nixon, C., Hatthakarnku, P., Campbell, A. D., Leedham, S. J., Edwards, J., Dunne, P. D., Barry, S. T., Graham, G. J., Sansom, O. J. (2023) Macrophage reprogramming—rather than depletion—is efficacious in a specific subset of colorectal tumor models. Research Square, (doi: 10.21203/rs.3.rs-3212822/v1)

Suzuki, T. et al. (2023) β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer. Cancer Immunology Research, 11, pp. 1137-1155. (doi: 10.1158/2326-6066.CIR-22-0644)

Vande Voorde, J. et al. (2023) Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature Metabolism, 5, pp. 1303-1318. (doi: 10.1038/s42255-023-00857-0)

Kristeleit, R., Plummer, R., Jones, R., Carter, L., Blagden, S., Sarker, D., Arkenau, T., Evans, T. R. J., Danson, S., Symeonides, S. N., Veal, G. J., Klencke, B. J., Kowalski, M. M., Banerji, U. (2023) A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer. British Journal of Cancer, 129, pp. 38-45. (doi: 10.1038/s41416-023-02279-x)

Solovyeva, O., Dimairo, M., Weir, C. J., Hee, S. W., Espinasse, A., Ursino, M., Patel, D., Kightley, A., Hughes, S., Jaki, T., Mander, A., Evans, T. R. J., Lee, S., Hopewell, S., Rantell, K. R., Chan, A.-W., Bedding, A., Stephens, R., Richards, D., Roberts, L., Kirkpatrick, J., de Bono, J., Yap, C. (2023) Development of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE study. BMC Medicine, 21, (doi: 10.1186/s12916-023-02937-0)

Murphy, M., McCaughan, E., Thompson, G., Carson, M. A., Hanna, J. R., Donovan, M., Wilson, R. H., Fitzsimons, D. (2023) Trusting relationships between patients with non-curative cancer and healthcare professionals create ethical obstacles for informed consent in clinical trials: a grounded theory study. BMC Palliative Care, 22, (doi: 10.1186/s12904-023-01204-6)

Whyte, D., Skalka, G., Walsh, P., Wilczynska, A., Paul, N. R., Mitchel, C., Nixon, C., Clarke, W., Bushell, M., Morton, J. P., Murphy, D. J., Muthalagu, N. (2023) NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β-dependent regulation of PLK4. Molecular Oncology, 17, pp. 1212-1227. (doi: 10.1002/1878-0261.13425)

Farahmand, P., Gyuraszova, K., Rooney, C., Raffo-Iraolagoitia, X. L., Jayasekera, G., Hedley, A., Johnson, E., Chernova, T., Malviya, G., Hall, H., Monteverde, T., Blyth, K., Duffin, R., Carlin, L. M., Lewis, D., le Quesne, J., MacFarlane, M., Murphy, D. J. (2023) Asbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma. Frontiers in Toxicology, 5, (doi: 10.3389/ftox.2023.1200650)

Hatthakarnkul, P., Ammar, A., Pennel, K. A.F., Officer-Jones, L., Cusumano, S., Quinn, J. A., Matly, A. A. M., Alexander, P. G., Hay, J., Andersen, D., Lynch, G., Van Wyk, H. C., Maka, N., McMillan, D. C., Le Quesne, J., Thuwajit, C., Edwards, J. (2023) Protein expression of S100A2 reveals it association with patient prognosis and immune infiltration profile in colorectal cancer. Journal of Cancer, 14, pp. 1837-1847. (doi: 10.7150/jca.83910)

Tibbo, A. J., Hartley, A., Vasan, R., Shaw, R., Galbraith, L., Mui, E., Leung, H. Y., Ahmad, I. (2023) MBTPS2 acts as a regulator of lipogenesis and cholesterol synthesis through SREBP signalling in prostate cancer. British Journal of Cancer, 128, pp. 1991-1999. (doi: 10.1038/s41416-023-02237-7)

Pennel, K., Morrow, E., Hatthakarnkul, P., Leslie, H., Mallon, E., Andersen, D., Jamieson, N., McMillan, D., Roseweir, A., Edwards, J. (2023) High expression of STAT3 within the tumour-associated stroma predicts poor outcome in breast cancer patients. Cancer Medicine, 12, pp. 13225-13240. (doi: 10.1002/cam4.6014)

Johnstone, M. S., Stoops, R., Lynch, G., Hay, J., Jawny, J., Sloan, W., Edwards, J., McSorley, S. T. (2023) Risk stratification for the detection of metachronous polyps after bowel screening polypectomy: clinical outcomes from the Integrated Technologies for Improved Polyp Surveillance (INCISE) study cohort. BJS Open, 7, (doi: 10.1093/bjsopen/zrad034)

Hamid, O., Hassel, J. C., Shoushtari, A. N., Meier, F., Bauer, T. M., Salama, A. K.S., Kirkwood, J. M., Ascierto, P. A., Lorigan, P. C., Mauch, C., Orloff, M., Evans, T. R. J., Holland, C., Edukulla, R., Abedin, S. E., Middleton, M. R. (2023) Tebentafusp in combination with durvalumab and/or tremelimumab in patients with metastatic cutaneous melanoma: a phase 1 study. Journal for ImmunoTherapy of Cancer, 11, (doi: 10.1136/jitc-2023-006747)

Liang, S., Almohammed, R., Cowling, V. H. (2023) The RNA cap methyltransferases RNMT and CMTR1 co-ordinate gene expression during neural differentiation. Biochemical Society Transactions, 51, pp. 1131-1141. (doi: 10.1042/BST20221154)

Yang, F., Nourse, C., Helgason, G. V., Kirschner, K. (2023) Unraveling heterogeneity in the aging hematopoietic stem cell compartment: an insight from single-cell approaches. HemaSphere, 7, (doi: 10.1097/hs9.0000000000000895)

Rattigan, K. M., Zarou, M.-M., Helgason, G. V. (2023) Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity. Blood, 141, pp. 2553-2565. (doi: 10.1182/blood.2022018258)

Mittal, A., Al-Ezzi, E., Li, X., Moloney, B., Wilson, B., Spiliopoulou, P., Sridhar, S., Fallah-Rad, N., Chung, P., James Hamilton, R., O’malley, M., Hansen, A. R. (2023) The role of cytoreductive nephrectomy and systemic therapy in the management of tumour thrombus in patients with metastatic renal cell carcinoma. British Journal of Cancer, 128, pp. 1888-1896. (doi: 10.1038/s41416-023-02166-5)

Vitale, I. et al. (2023) Apoptotic cell death in disease—current understanding of the NCCD 2023. Cell Death and Differentiation, 30, pp. 1097-1154. (doi: 10.1038/s41418-023-01153-w)

Conway, J. R. W. et al. (2023) Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse. Science Advances, 9, (doi: 10.1126/sciadv.adf9063)

Ng, K. W. et al. (2023) Antibodies against endogenous retroviruses promote lung cancer immunotherapy. Nature, 616, pp. 563-573. (doi: 10.1038/s41586-023-05771-9)

Martínez-Ruiz, C. et al. (2023) Genomic–transcriptomic evolution in lung cancer and metastasis. Nature, 616, pp. 543-552. (doi: 10.1038/s41586-023-05706-4)

Frankell, A. M. et al. (2023) The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature, 616, pp. 525-533. (doi: 10.1038/s41586-023-05783-5)

Al Bakir, M. et al. (2023) The evolution of non-small cell lung cancer metastases in TRACERx. Nature, 616, pp. 534-542. (doi: 10.1038/s41586-023-05729-x)

Abbosh, C. et al. (2023) Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA. Nature, 616, pp. 553-562. (doi: 10.1038/s41586-023-05776-4)

Wood, C. S., Pennel, K. A.F., Leslie, H., Legrini, A., Cameron, A. J., Melissourgou-Syka, L., Quinn, J. A., van Wyk, H. C., Hay, J., Roseweir, A. K., Nixon, C., Roxburgh, C. S.D., McMillan, D. C., Biankin, A. V., Sansom, O. J., Horgan, P. G., Edwards, J., Steele, C. W., Jamieson, N. B. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83, pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794)

Shamis, S. A.K., Edwards, J., McMillan, D. C. (2023) The relationship between carbonic anhydrase IX (CAIX) and patient survival in breast cancer: systematic review and meta-analysis. Diagnostic Pathology, 18, (doi: 10.1186/s13000-023-01325-9)

Woodley, K., Dillingh, L. S., Giotopoulos, G., Madrigal, P., Rattigan, K. M., Philippe, C., Dembitz, V., Magee, A. M. S., Asby, R., van de Lagemaat, L. N., Mapperley, C., James, S. C., Prehn, J. H. M., Tzelepis, K., Rouault-Pierre, K., Vassiliou, G. S., Kranc, K. R., Helgason, G. V., Huntly, B. J. P., Gallipoli, P. (2023) Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death. Nature Communications, 14, (doi: 10.1038/s41467-023-37652-0)

Hill, W. et al. (2023) Lung adenocarcinoma promotion by air pollutants. Nature, 616, pp. 159-167. (doi: 10.1038/s41586-023-05874-3)

Chung, T., Garcia, L., Swamynathan, M. M., Froeling, F. E.M., Trotman, L. C., Tuveson, D. A., Lyons, S. K. (2023) Internally controlled and dynamic optical measures of functional tumor biology. Analytical Chemistry, 95, pp. 5661-5670. (doi: 10.1021/acs.analchem.2c05450)

Fernando, F., Innes, A. J., Claudiani, S., Pryce, A., Hayden, C., Byrne, J., Gallipoli, P., Copland, M., Apperley, J. F., Milojkovic, D. (2023) The outcome of post-transplant asciminib in patients with chronic myeloid leukaemia. Bone Marrow Transplantation, 58, pp. 826-828. (doi: 10.1038/s41409-023-01975-9)

Sandilands, E., Freckmann, E. C., Cumming, E. M., Román-Fernández, A., McGarry, L., Anand, J., Galbraith, L., Mason, S., Patel, R., Nixon, C., Cartwright, J., Leung, H. Y., Blyth, K., Bryant, D. M. (2023) The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels. Journal of Cell Biology, 222, (doi: 10.1083/jcb.202206115)

Al-Sawaf, O. et al. (2023) Body composition and lung cancer-associated cachexia in TRACERx. Nature Medicine, 29, pp. 846-858. (doi: 10.1038/s41591-023-02232-8)

Karasaki, T. et al. (2023) Evolutionary characterization of lung adenocarcinoma morphology in TRACERx. Nature Medicine, 29, pp. 833-845. (doi: 10.1038/s41591-023-02230-w)

Patterson, S. D., Copland, M. (2023) The bone marrow immune microenvironment in CML: treatment responses, treatment-free remission, and therapeutic vulnerabilities. Current Hematologic Malignancy Reports, 18, pp. 19-32. (doi: 10.1007/s11899-023-00688-6)

Barry, S. T., Gabrilovich, D. I., Sansom, O. J., Campbell, A. D., Morton, J. P. (2023) Therapeutic targeting of tumour myeloid cells. Nature Reviews Cancer, 23, pp. 216-237. (doi: 10.1038/s41568-022-00546-2)

Numprasit, W., Yangngam, S., Prasopsiri, J., Quinn, J. A., Edwards, J., Thuwajit, C. (2023) Carbonic anhydrase IX-related tumoral hypoxia predicts worse prognosis in breast cancer: a systematic review and meta-analysis. Frontiers in Medicine, 10, (doi: 10.3389/fmed.2023.1087270)

Coffelt, S. B., Suzuki, T. (2023) γδ T cells turn the tables on immune-evasive colon cancer. Med, 4, pp. 141-142. (doi: 10.1016/j.medj.2023.02.007)

Bennett, S. S., Leung, H. Y., Ahmad, I. (2023) A cohort analysis of patients receiving neoadjuvant androgen deprivation therapy prior to robot-assisted laparoscopic prostatectomy during the Covid-19 pandemic. Journal of Clinical Urology, 16, pp. 13-139. (doi: 10.1177/20514158211022216)

AlRasheedi, M., Han, S., Thygesen, H., Neilson, M., Hendry, F., Alkarn, A., Maclay, J. D., Leung, H. Y. (2023) A comparative evaluation of mediastinal nodal SUVmax and derived ratios from 18F-FDG PET/CT imaging to predict nodal metastases in non-small cell lung cancer. Diagnostics, 13, (doi: 10.3390/diagnostics13071209)

Mussai, F., De Santo, C., Cheng, P., Thomas, I. F., Ariti, C., Upton, L., Scarpa, U., Stavrou, V., Sydenham, M., Burnett, A. K., Knapper, S. K., Mehta, P., McMullin, M. F., Copland, M., Russell, N. H., Dennis, M. (2023) A randomised evaluation of low-dose Ara-C plus pegylated recombinant arginase BCT-100 versus low dose Ara-C in older unfit patients with acute myeloid leukaemia: results from the LI-1 trial. British Journal of Haematology, 200, pp. 573-578. (doi: 10.1111/bjh.18560)

Katz, S. I., Straus, C. M., Roshkovan, L., Blyth, K. G., Frauenfelder, T., Gill, R. R., Lalezari, F., Erasmus, J., Nowak, A. K., Gerbaudo, V. H., Francis, R. J., Armato, S. G. (2023) Considerations for imaging of malignant pleural mesothelioma: a consensus statement from the International Mesothelioma Interest Group. Journal of Thoracic Oncology, 18, pp. 278-298. (doi: 10.1016/j.jtho.2022.11.018)

Villar, V. H., Allega, M. F., Deshmukh, R., Ackermann, T., Nakasone, M. A., Vande Voorde, J., Drake, T. M., Oetjen, J., Bloom, A., Nixon, C., Müller, M., May, S., Tan, E. H., Vereecke, L., Jans, M., Blancke, G., Murphy, D. J., Huang, D. T., Lewis, D. Y., Bird, T. G., Sansom, O. J., Blyth, K., Sumpton, D., Tardito, S. (2023) Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology, 19, pp. 292-300. (doi: 10.1038/s41589-022-01154-9)

Vita, F., Olaizola Rebè, I., Amato, F., Rae, C., Marco, S., Banales, J. M., Braconi, C. (2023) Heterogeneity of cholangiocarcinoma immune biology. Cells, 12, (doi: 10.3390/cells12060846)

Stavrou, V., Fultang, L., Booth, S., De Simone, D., Bartnik, A., Scarpa, U., Gneo, L., Panetti, S., Potluri, S., Almowaled, M., Barlow, J., Jankevics, A., Lloyd, G., Southam, A., Priestman, D. A., Cheng, P., Dunn, W., Platt, F., Endou, H., Craddock, C., Keeshan, K., Mussai, F., De Santo, C. (2023) Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment. Cancer Immunology, Immunotherapy, 72, pp. 543-560. (doi: 10.1007/s00262-022-03268-4)

Marchi, S., Guilbaud, E., Tait, S. W.G., Yamazaki, T., Galluzzi, L. (2023) Mitochondrial control of inflammation. Nature Reviews Immunology, 23, pp. 159-173. (doi: 10.1038/s41577-022-00760-x)

Espinasse, A., Solovyeva, O., Dimairo, M., Weir, C., Jaki, T., Mander, A., Kightley, A., Evans, J., Lee, S., Bedding, A., Hopewell, S., Rantell, K., Liu, R., Chan, A.-W., De Bono, J., Yap, C. (2023) SPIRIT and CONSORT extensions for early phase dose-finding clinical trials: the DEFINE (DosE-FIndiNg Extensions) study protocol. BMJ Open, 13, (doi: 10.1136/bmjopen-2022-068173)

Leak, S., Horne, G., Copland, M. (2023) Targeting BCR-ABL1-positive leukaemias, a review article. Cambridge Prisms: Precision Medicine, 1, (doi: 10.1017/pcm.2023.9)

Alexander, P.G., van Wyk, H.C., Pennel, K.A.F., Hay, J., McMillan, D.C., Horgan, P.G., Roxburgh, C.S.D., Edwards, J., Park, J.H. (2023) The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer. British Journal of Cancer, 128, pp. 556-567. (doi: 10.1038/s41416-022-02069-x)

Coetzee, A. S., Carter, E. P., Rodríguez-Fernández, L., Heward, J., Wang, Q., Karim, S. A., Boughetane, L., Milton, C., Uyulur, F., Morton, J. P., Kocher, H. M., Grose, R. P. (2023) Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1. Oncogene, 42, pp. 419-500. (doi: 10.1038/s41388-022-02513-5)

Heilig, R., Lee, J., Tait, S. W.G. (2023) Mitochondrial DNA in cell death and inflammation. Biochemical Society Transactions, 51, pp. 457-472. (doi: 10.1042/BST20221525)

Rushworth, L. K., Loveridge, C., Salji, M., MacLeod, M., Mui, E., Sumpton, D., Neilson, M., Hedley, A., Alexander, L., McCartney, E., Patel, R., Wallace, J., Delles, C., Jones, R., Leung, H. Y. (2023) Phase II proof of concept study of atorvastatin in castration resistant prostate cancer. BJU International, 131, pp. 236-243. (doi: 10.1111/bju.15851)

Turner, N. C. et al. (2023) Results of the c-TRAK TN trial: a clinical trial utilising ctDNA mutation tracking to detect molecular residual disease and trigger intervention in patients with moderate and high-risk early stage triple negative breast cancer. Annals of Oncology, 34, pp. 200-211. (doi: 10.1016/j.annonc.2022.11.005)

Dreyer, S. B., Rae, S., Bisset, K., Upstill-Goddard, R., Gemenetzis, G., Johns, A. L., Australian Pancreatic Cancer Genome Initiative3,, , Glasgow Precision Oncology Laboratory1, , Dickson, E. J., Mittal, A., Gill, A. J., Duthie, F., pea, A., Lawlor, R. T., Scarpa, A., Salvia, R., Pulvirenti, A., Zerbi, A., Marchesi, F., McKay, C. J., Biankin, A. V., Samra, J. S., Chang, D. K., Jamieson, N. B. (2023) The impact of molecular subtyping on pathological staging of pancreatic cancer. Annals of Surgery, 277, pp. e396-e405. (doi: 10.1097/SLA.0000000000005050)

Spiliopoulou, P., Janse van Rensburg, H. J., Avery, L., Kulasingam, V., Razak, A., Bedard, P., Hansen, A., Chruscinski, A., Wang, B., Kulikova, M., Chen, R., Speers, V., Nguyen, A., Lee, J., Coburn, B., Spreafico, A., Siu, L. L. (2023) Longitudinal efficacy and toxicity of SARS-CoV-2 vaccination in cancer patients treated with immunotherapy. Cell Death and Disease, 14, (doi: 10.1038/s41419-022-05548-4)

Koessinger, D., Novo, D., Koessinger, A., Campos, A., Peters, J., Dutton, L., Paschke, P., Zerbst, D., Moore, M., Mitchell, L., Neilson, M., Stevenson, K., Chalmers, A., Tait, S., Birch, J., Norman, J. (2023) Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness. Neuro-Oncology Advances, 5, (doi: 10.1093/noajnl/vdad067)

Mehta, P., Telford, N., Wragg, C., Dillon, R., Freeman, S., Finnegan, D., Hamblin, A., Copland, M., Knapper, S. (2023) A British Society for Haematology good practice paper: Recommendations for laboratory testing of UK patients with acute myeloid leukaemia. British Journal of Haematology, 200, pp. 150-159. (doi: 10.1111/bjh.18516)

Sykes, R. et al. (2023) Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19. Open Heart, 10, (doi: 10.1136/openhrt-2022-002192)

Tandon, V., Moreno, R., Allmeroth, K., Quinn, J., Wiley, S. E., Nicely, L. G., Denzel, M. S., Edwards, J., de la Vega, L., Banerjee, S. (2023) Dual inhibition of HSF1 and DYRK2 impedes cancer progression. Bioscience Reports, 34, (doi: 10.1042/BSR20222102)

Spiliopoulou, P., Vornicova, O., Genta, S., Spreafico, A. (2023) Shaping the future of immunotherapy targets and biomarkers in melanoma and non-melanoma cutaneous cancers. International Journal of Molecular Sciences, 24, (doi: 10.3390/ijms24021294)

McGovern, J., Delaney, J., Forshaw, M. J., McCabe, G., Crumley, A. B., McIntosh, D., Laird, B. J., Horgan, P. G., McMillan, D. C., McSorley, S. T., Dolan, R. D. (2023) The relationship between computed tomography-derived sarcopenia, cardiopulmonary exercise testing performance, systemic inflammation, and survival in good performance status patients with oesophago-gastric cancer undergoing neoadjuvant treatment. JCSM Clinical Reports, 8, pp. 3-11. (doi: 10.1002/crt2.57)

Román-Fernández, A. et al. (2022) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9, (doi: 10.1126/sciadv.abq1858)

Flanagan, D. J. et al. (2022) Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features. Nature Communications, 13, (doi: 10.1038/s41467-022-35134-3)

Cousins, A., Olivares, O., Markert, E., Manoharan, A., Bubnova, X., Bresolin, S., Degn, M., Li, Z., Silvestri, D., McGregor, G., Tumanov, S., Sumpton, D., Kamphorst, J. J., Michie, A. M., Herzyk, P., Valsecchi, M. G., Yeoh, A. E., Schmiegelow, K., te Kronnie, G., Gottlieb, E., Halsey, C. (2022) Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways. Leukemia, 36, pp. 2903-2907. (doi: 10.1038/s41375-022-01722-x)

Thastrup, M., Duguid, A., Mirian, C., Schmiegelow, K., Halsey, C. (2022) Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions. Leukemia, 36, pp. 2751-2768. (doi: 10.1038/s41375-022-01714-x)

Kidd, A. C., Anderson, O., Cowell, G. W., Weir, A. J., Voisey, J. P., Evison, M., Tsim, S., Goatman, K. A., Blyth, K. G. (2022) Fully automated volumetric measurement of malignant pleural mesothelioma by deep learning AI: validation and comparison with modified RECIST response criteria. Thorax, 77, pp. 1251-1259. (doi: 10.1136/thoraxjnl-2021-217808)

van Wagensveld, L., van Baal, J. O. A. M., Timmermans, M., Gaillard, D., Borghuis, L., Coffelt, S. B., Rosenberg, E. H., Lok, C. A. R., Nijman, H. W., Kooreman, L. F. S., Sanders, J., de Bruijn, M., Wessels, L. F. A., van der Wiel, R., Rausch, C., Broeks, A., Kruitwagen, R. F. P. M., van der Aa, M. A., Sonke, G. S., Schouten, P. C., Van de Vijver, K. K., Horlings, H. M. (2022) Homologous recombination deficiency and cyclin E1 amplification are correlated with immune cell infiltration and survival in high-grade serous ovarian cancer. Cancers, 14, (doi: 10.3390/cancers14235965)

Johnstone, M. S., MacLeod, C., Digby, J., Al-Azzawi, Y., Pang, G., Watson, A. J.M., Strachan, J., Mowat, C., McSorley, S. T. (2022) Prevalence of repeat faecal immunochemical testing in symptomatic patients attending primary care. Colorectal Disease, 24, pp. 1498-1504. (doi: 10.1111/codi.16240)

Ali, A., Jamieson, N. B., Khan, I. Q., Chang, D., Giovannetti, E., Funel, N., Frampton, A.E., Morton, J., Sansom, O., Evans, T.R.J., Duthie, F., McKay, C. J., Samra, J.S., Gill, A. J., Biankin, A., Oien, K. A. (2022) Prognostic implications of microRNA-21 overexpression in pancreatic ductal adenocarcinoma: an international multicenter study of 686 patients. American Journal of Cancer Research, 12, pp. 5668-5683.

Savioli, F., Morrow, E. S., Dolan, R. D., Romics, L., Lannigan, A., Edwards, J., McMillan, D. C. (2022) Prognostic role of preoperative circulating systemic inflammatory response markers in primary breast cancer: meta-analysis. British Journal of Surgery, 109, pp. 1206-1215. (doi: 10.1093/bjs/znac319)

Smith, C., McMahon, A. D., Ross, A., Inman, G. J., Conway, D. I. (2022) Risk prediction models for head and neck cancer: a rapid review. Laryngoscope Investigative Otolaryngology, 7, pp. 1893-1908. (doi: 10.1002/lio2.982)

Patel, M., McAllister, M., Nagaraju, R., Al Badran, S. S. F., Edwards, J., McBain, A. J., Barriuso, J., Aziz, O. (2022) The intestinal microbiota in colorectal cancer metastasis - Passive observer or key player? Critical Reviews in Oncology/Hematology, 180, (doi: 10.1016/j.critrevonc.2022.103856)

Copland, M. (2022) Treatment of blast phase chronic myeloid leukaemia: a rare and challenging entity. British Journal of Haematology, 199, pp. 665-678. (doi: 10.1111/bjh.18370)

Evans, J., Keith, N., Paul, J. (2022) An analysis of Relative Telomere Length (RTL) during peri-operative chemotherapy in patients with operable gastric or gastro-oesophageal junction adenocarcinoma. (doi: 10.17504/protocols.io.ca5csg2w)

Parry, N., Busch, C., Aßmann, V., Cassels, J., Hair, A., Helgason, G. V., Wheadon, H., Copland, M. (2022) BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia. Cell Death Discovery, 8, (doi: 10.1038/s41420-022-01211-1)

Jamieson, S. A., Pudjihartono, M., Horne, C. R., Viloria, J. S., Dunlop, J. L., McMillan, H. D., Day, R. C., Keeshan, K., Murphy, J. M., Mace, P. D. (2022) Nanobodies identity an activated state of the TRIB2 pseudokinase. Structure, 30, pp. 1518-1529.e5. (doi: 10.1016/j.str.2022.08.006)

Gómez-Castañeda, E., Hopcroft, L. E.M., Rogers, S., Munje, C., Bittencourt-Silvestre, J., Copland, M., Vetrie, D., Holyoake, T., Jørgensen, H. G. (2022) Tyrosine kinase inhibitor independent gene expression signature in CML offers new targets for LSPC eradication therapy. Cancers, 14, (doi: 10.3390/cancers14215253)

Pennel, K. A. F., Quinn, J. A., Nixon, C., Inthagard, J., van Wyk, H. C., Chang, D., Rebus, S., GPOL Group, , Hay, J., Maka, N. N., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. C., Park, J. H., Roseweir, A. K., Steele, C. W., Edwards, J. (2022) CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer. Journal of Pathology: Clinical Research, 8, pp. 509-520. (doi: 10.1002/cjp2.290)

Bellomo, G., Rainer, C., Quaranta, V., Astuti, Y., Raymant, M., Boyd, E., Stafferton, R., Campbell, F., Ghaneh, P., Halloran, C. M., Hammond, D. E., Morton, J. P., Palmer, D., Vimalachandran, D., Jones, R., Mielgo, A., Schmid, M. C. (2022) Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis. Gut, 71, pp. 2284-2299. (doi: 10.1136/gutjnl-2021-325272)

Bryce, A. S., Dreyer, S. B., Froeling, F. E.M., Chang, D. K. (2022) Exploring the biology of cancer-associated fibroblasts in pancreatic cancer. Cancers, 14, (doi: 10.3390/cancers14215302)

Conway, R. J. H., Symonds, J., Walton, D., Probets, J., Comins, C., Stadon, L., Harvey, J. E., Blyth, K. G., Maskell, N. A., Bibby, A. C. (2022) Protocol for a prospective observational cohort study collecting data on demographics, symptoms and biomarkers in people with mesothelioma (ASSESS-meso) BMJ Open, 12, (doi: 10.1136/bmjopen-2022-060850)

Edwards, S. C., Hedley, A., Hoevenaar, W. H.M., Wiesheu, R., Glauner, T., Kilbey, A., Shaw, R., Boufea, K., Batada, N., Hatano, S., Yoshikai, Y., Blyth, K., Miller, C., Kirschner, K., Coffelt, S. B. (2022) PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells. Journal of Experimental Medicine, 220, (doi: 10.1084/jem.20211431)

Yanchus, C. et al. (2022) A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation. Science, 378, pp. 68-78. (doi: 10.1126/science.abj2890)

Vringer, E., Tait, S. W.G. (2022) Mitochondria and cell death-associated inflammation. Cell Death and Differentiation, 30, pp. 304-312. (doi: 10.1038/s41418-022-01094-w)

Koessinger, A. L. et al. (2022) Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics. Cell Death and Differentiation, 29, pp. 2089-2104. (doi: 10.1038/s41418-022-01001-3)

Dennis, M., Copland, M., Kaur, H., Kell, J., Nikolousis, E., Mehta, P., Palanicawandar, R., Potter, V., Raj, K., Thomas, I., Wilson, A. (2022) Management of older patients with frailty and acute myeloid leukaemia: a British Society for Haematology good practice paper. British Journal of Haematology, 199, pp. 205-221. (doi: 10.1111/bjh.18369)

Lebecque, B., Bourgne, C., Munje, C., Berger, J., Tassin, T., Cony-Makhoul, P., Guerci, A., Johnson-Ansah, H., Liu, W., Saugues, S., Tchirkov, A., Vetrie, D., Copland, M., Berger, M. G. (2022) The spliceosome: a new therapeutic target in chronic myeloid leukaemia. Cancers, 14, (doi: 10.3390/cancers14194695)

Freckmann, E. C., Sandilands, E., Cumming, E., Neilson, M., Roman-Fernandez, A., Nikolatou, K., Nacke, M., Lannagan, T. R.M., Hedley, A., Strachan, D., Salji, M., Morton, J. P., McGarry, L., Leung, H. Y., Sansom, O. J., Miller, C. J., Bryant, D. M. (2022) Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13, (doi: 10.1038/s41467-022-32958-x)

Kalkavan, H., Chen, M. J., Crawford, J. C., Quarato, G., Fitzgerald, P., Tait, S. W.G., Goding, C. R., Green, D. R. (2022) Sublethal cytochrome c release generates drug-tolerant persister cells. Cell, 185, pp. 3356-3374.e22. (doi: 10.1016/j.cell.2022.07.025)

Ismail, N. F. B., Foth, M., Yousef, A. R. E., Cui, N., Leach, J. D.G., Jamieson, T., Karim, S. A., Salmond, J. M., Morton, J. P., Iwata, T. (2022) Loss of Cxcr2 in myeloid cells promotes tumour progression and T cell infiltration in invasive bladder cancer. Bladder Cancer, 8, pp. 277-290. (doi: 10.3233/BLC-211645)

Raggi, C., Taddei, M. L., Rae, C., Braconi, C., Marra, F. (2022) Metabolic reprogramming in cholangiocarcinoma. Journal of Hepatology, 77, pp. 849-864. (doi: 10.1016/j.jhep.2022.04.038)

Alexander, P. G., Matly, A. A.M., Jirapongwattana, N., Pennel, K. A.F., Van Wyk, H. C., McMillan, D. C., Horgan, P. G., Roxburgh, C. S.D., Thuwajit, C., Roseweir, A. K., Quinn, J., Park, J. H., Edwards, J. (2022) The relationship between the Glasgow Microenvironment Score and markers of epithelial-mesenchymal transition in TNM II-III colorectal cancer. Human Pathology, 127, pp. 1-11. (doi: 10.1016/j.humpath.2022.05.012)

Pal, D., Blair, H., Parker, J., Hockney, S., Beckett, M., Singh, M., Tirtakusuma, R., Nelson, R., McNeill, H., Angel, S. H., Wilson, A., Nizami, S., Nakjang, S., Zhou, P., Schwab, C., Sinclair, P., Russell, L. J., Coxhead, J., Halsey, C., Allan, J. M., Harrison, C. J., Moorman, A. V., Heidenreich, O., Vormoor, J. (2022) hiPSC-derived bone marrow milieu identifies a clinically actionable driver of niche-mediated treatment resistance in leukemia. Cell Reports Medicine, 3, (doi: 10.1016/j.xcrm.2022.100717)

Winter, M., Coleman, R., Kendall, J., Palmieri, C., Twelves, C., Howell, S., MacPherson, I., Wilson, C., Purohit, K., Gath, J., Taylor, C., Eastell, R., Murden, G., Brown, S. R., Rathbone, E., Brown, J. (2022) A phase IB and randomised phase IIA trial of CApecitabine plus Radium-223 (Xofigo™) in breast cancer patients with BONe metastases: CARBON trial results. Journal of Bone Oncology, 35, (doi: 10.1016/j.jbo.2022.100442)

Gould, L. E., Pring, E. T., Drami, I., Moorghen, M., Naghibi, M., Jenkins, J. T., Steele, C. W., Roxburgh, C. S.D. (2022) A systematic review of the pathological determinants of outcome following resection by pelvic exenteration of locally advanced and locally recurrent rectal cancer. International Journal of Surgery, 104, (doi: 10.1016/j.ijsu.2022.106738)

Yangngam, S., Prasopsiri, J., Hatthakarnkul, P., Thongchot, S., Thuwajit, P., Yenchitsomanus, P.-t., Edwards, J., Thuwajit, C. (2022) Cellular localization of nucleolin determines the prognosis in cancers: a meta-analysis. Journal of Molecular Medicine, 100, pp. 1145-1157. (doi: 10.1007/s00109-022-02228-w)

Muñoz‐Martínez, S. et al. (2022) Outcome of liver cancer patients with SARS‐CoV‐2 infection: an international, multicentre, cohort study. Liver International, 42, pp. 1891-1901. (doi: 10.1111/liv.15320)

Khan, K. S., Gall, L. S., Dreyer, S., McCollum, C., Chuntamongkol, R., Craig, C., MacKay, C., Macdonald, A., Forshaw, M. (2022) Stage migration in newly diagnosed oesophagogastric cancer during the first wave of the COVID-19 pandemic. British Journal of Surgery, 109, pp. 773-774. (doi: 10.1093/bjs/znac112)

Fleming, L., Agnew, S., Peddie, N., Crawford, M., Dixon, D., MacPherson, I. (2022) The impact of medication side effects on adherence and persistence to hormone therapy in breast cancer survivors: a quantitative systematic review. Breast, 64, pp. 63-84. (doi: 10.1016/j.breast.2022.04.010)

Patel, R., Ford, C. A., Rodgers, L., Rushworth, L. K., Fleming, J., Mui, E., Zhang, T., Watson, D., Lynch, V., Mackay, G., Sumpton, D., Sansom, O. J., Vande Voorde, J., Leung, H. Y. (2022) Cyclocreatine suppresses creatine metabolism and impairs prostate cancer progression. Cancer Research, 82, pp. 2565-2575. (doi: 10.1158/0008-5472.CAN-21-1301)

Morrison, A., Marshall-Mckenna, R., McFadyen, A. K., Hutchison, C., Rice, A.-M., Stirling, L., McIlroy, P., MacPherson, I. R. (2022) A randomised controlled trial of interventions for taxane-induced nail toxicity in women with early breast cancer. Scientific Reports, 12, (doi: 10.1038/s41598-022-13327-6)

Zacharioudakis, E., Agianian, B., Kumar MV, V., Biris, N., Garner, T. P., Rabinovich-Nikitin, I., Ouchida, A. T., Margulets, V., Nordstrøm, L. U., Riley, J. S., Dolgalev, I., Chen, Y., Wittig, A. J. H., Pekson, R., Mathew, C., Wei, P., Tsirigos, A., Tait, S. W.G., Kirshenbaum, L. A., Kitsis, R. N., Gavathiotis, E. (2022) Modulating mitofusins to control mitochondrial function and signaling. Nature Communications, 13, (doi: 10.1038/s41467-022-31324-1)

El Helali, A., Plummer, R., Jayson, G. C., Coyle, V. M., Drew, Y., Mescallado, N., Harris, N., Clamp, A. R., McCann, J., Swaisland, H., Kennedy, R. D., Cranston, A. N., Wilson, R. H. (2022) A first-in-human Phase I dose-escalation trial of the novel therapeutic peptide, ALM201, demonstrates a favourable safety profile in unselected patients with ovarian cancer and other advanced solid tumours. British Journal of Cancer, 127, pp. 92-101. (doi: 10.1038/s41416-022-01780-z)

Bedawi, E. O., Ur Rehman, K., Sivakumar, D. P., Ferguson, K., Ajmal, S., Graham, E., Panchal, R. K., Corcoran, J. P., Blyth, K. G., Rahman, N. M., West, A. (2022) The impact of the COVID-19 pandemic on pleural infection incidence: a UK multicentre retrospective analysis. ERJ Open Research, 8, (doi: 10.1183/23120541.00206-2022)

Johnstone, M. S., Miller, G., Pang, G., Burton, P., Kouronis, G., Winter, J., Crighton, E., Mansouri, D., Witherspoon, P., Smith, K., McSorley, S. T. (2022) Alternative diagnoses and demographics associated with a raised quantitative faecal immunochemical test in symptomatic patients. Annals of Clinical Biochemistry, 59, pp. 277-287. (doi: 10.1177/00045632221076771)

Sooriakumaran, P., Wilson, C., Rombach, I., Hassanali, N., Aning, J., D. Lamb, A., Cathcart, P., Eden, C., Ahmad, I., Rajan, P., Sridhar, A., Bryant, R. J., Elhage, O., Cook, J., Leung, H., Soomro, N., Kelly, J., Nathan, S., Donovan, J. L., Hamdy, F. C. (2022) Feasibility and safety of radical prostatectomy for oligo‐metastatic prostate cancer: the Testing Radical prostatectomy in men with prostate cancer and oligo‐Metastases to the bone (TRoMbone) trial. BJU International, 130, pp. 43-53. (doi: 10.1111/bju.15669)

Vaziri-Gohar, A. et al. (2022) Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors. Nature Cancer, 3, pp. 852-865. (doi: 10.1038/s43018-022-00393-y)

Sala, A., Cameron, J. M., Jenkins, C. A., Barr, H., Christie, L., Conn, J. J.A., Evans, T. R. J., Harris, D. A., Palmer, D. S., Rinaldi, C., Theakstone, A. G., Baker, M. J. (2022) Liquid biopsy for pancreatic cancer detection using infrared spectroscopy. Cancers, 14, (doi: 10.3390/cancers14133048)

Robertson, N. A., Latorre-Crespo, E., Terradas-Terradas, M., Lemos-Portela, J., Purcell, A. C., Livesey, B. J., Hillary, R. F., Murphy, L., Fawkes, A., MacGillivray, L., Copland, M., Marioni, R. E., Marsh, J. A., Harris, S. E., Cox, S. R., Deary, I. J., Schumacher, L. J., Kirschner, K., Chandra, T. (2022) Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects. Nature Medicine, 28, pp. 1439-1446. (doi: 10.1038/s41591-022-01883-3)

Henriksen, P. A., Hall, P., Oikonomidou, O., MacPherson, I. R., Maclean, M., Lewis, S., McVicars, H., Broom, A., Scott, F., McKay, P., Borley, A., Rowntree, C., Lord, S., Collins, G., Radford, J., Guppy, A., Payne, J. R., Newby, D. E., Mills, N. L., Lang, N. N. (2022) Rationale and design of the Cardiac CARE trial: A randomized trial of troponin-guided neurohormonal blockade for the prevention of anthracycline cardiotoxicity. Circulation: Heart Failure, 15, (doi: 10.1161/CIRCHEARTFAILURE.121.009445)

Ianniciello, A., Helgason, G. V. (2022) Targeting ULK1 in cancer stem cells: insight from chronic myeloid leukemia. Autophagy, 18, pp. 1734-1736. (doi: 10.1080/15548627.2022.2041152)

Shamis, S. A.K., Quinn, J., Mallon, E. E.A., Edwards, J., McMillan, D. C. (2022) The relationship between the tumor cell expression of hypoxic markers and survival in patients with ER-positive invasive ductal breast cancer. Journal of Histochemistry and Cytochemistry, 70, pp. 479-494. (doi: 10.1369/00221554221110280)

Ahmed, A., Giampazolias, E., Patel, R., Leung, H., Tait, S. W.G. (2022) Caspase-independent cell death as a novel therapy for advanced prostate cancer.

Evans, J., Keith, N., Paul, J. (2022) An analysis of Relative Telomere Length (RTL) during chemotherapy in patients with advanced gastro-oesophageal adenocarcinoma. (doi: 10.17504/protocols.io.n92ldznenv5b/v1)

Coombes, R.C., Badman, P.D., Lozano-Kuehne, J.P., Liu, X., MacPherson, I. R., Zubairi, I., Baird, R.D., Rosenfeld, N., Garcia-Corbacho, J., Cresti, N., Plummer, R., Armstrong, A., Allerton, R., Landers, D., Nicholas, H., McLellan, L., Lim, A., Mouliere, F., Pardo, O.E., Seckl, M.J. (2022) Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer. Nature Communications, 13, (doi: 10.1038/s41467-022-30666-0)

Patel, M., Pennel, K. A.F., Quinn, J. A., Hood, H., Chang, D. K., Biankin, A. V., Rebus, S., Roseweir, A. K., Park, J. H., Horgan, P. G., McMillan, D. C., Edwards, J. (2022) Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer. British Journal of Cancer, 126, pp. 1704-1714. (doi: 10.1038/s41416-022-01729-2)

Morrow, A. J. et al. (2022) A multisystem, cardio-renal investigation of post-COVID-19 illness. Nature Medicine, 28, pp. 1303-1313. (doi: 10.1038/s41591-022-01837-9)

Razis, E. et al. (2022) Assessment of the management of carcinomatous meningitis from breast cancer globally: a study by the Breast International Group Brain Metastasis Task Force. ESMO Open, 7, (doi: 10.1016/j.esmoop.2022.100483)

Kay, E. J. et al. (2022) Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. Nature Metabolism, 4, pp. 693-710. (doi: 10.1038/s42255-022-00582-0)

Bombaci, G., Sarangdhar, M. A., Andina, N., Tardivel, A., Yu, E. C.-W., Mackie, G. M., Pugh, M., Ozan, V. B., Banz, Y., Spinetti, T., Hirzel, C., Youd, E., Schefold, J. C., Taylor, G., Gazdhar, A., Bonadies, N., Angelillo-Scherrer, A., Schneider, P., Maslowski, K. M., Allam, R. (2022) LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity. Life Science Alliance, 5, (doi: 10.26508/lsa.202101226)

Colyn, L. et al. (2022) New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming. Journal of Experimental and Clinical Cancer Research, 41, (doi: 10.1186/s13046-022-02386-2)

Pirillo, C., Birch, F., Tissot, F., Anton, S. G., Haltalli, M., Tini, V., Kong, I., Piot, C., Partridge, B., Pospori, C., Keeshan, K., Santamaria, S., Hawkins, E., Falini, B., Marra, A., Duarte, D., Lee, C. F., Roberts, E., Celso, C. L. (2022) Metalloproteinase inhibition reduces AML growth, prevents stem cell loss and improves chemotherapy effectiveness. Blood Advances, 6, pp. 3126-3141. (doi: 10.1182/bloodadvances.2021004321)

Cao, K., Riley, J. S., Heilig, R., Montes-Gómez, A. E., Vringer, E., Berthenet, K., Cloix, C., Elmasry, Y., Spiller, D. G., Ichim, G., Campbell, K. J., Gilmore, A. P., Tait, S. W.G. (2022) Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage. Developmental Cell, 57, pp. 1211-1225.e6. (doi: 10.1016/j.devcel.2022.03.019)

Tait, S. W.G. (2022) Killing cells using light (activated) sabers. Journal of Cell Biology, 221, (doi: 10.1083/jcb.202205018)

Kidger, A. M., Saville, M. K., Rushworth, L. K., Davidson, J., Stellzig, J., Ono, M., Kuebelsbeck, L. A., Janssen, K.-P., Holzmann, B., Morton, J. P., Sansom, O. J., Caunt, C. J., Keyse, S. M. (2022) Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6. Oncogene, 41, pp. 2811-2823. (doi: 10.1038/s41388-022-02302-0)

Müller, M. et al. (2022) Human-correlated genetic HCC models identify combination therapy for precision medicine [Pre-print] Research Square, (doi: 10.21203/rs.3.rs-1638504/v1)

Lal, R., Ritchie, J., Richmond, L., Keeshan, K. (2022) Detecting endogenous TRIB2 protein expression by flow cytometry and western blotting. Academic Press

Casolino, R. et al. (2022) Bridging the equity gap in patient education: the biliary tract cancer BABEL project. Lancet Oncology, 23, pp. 568-570. (doi: 10.1016/S1470-2045(22)00143-7)

Izquierdo-Sanchez, L. et al. (2022) Cholangiocarcinoma landscape in Europe: diagnostic, prognostic and therapeutic insights from the ENSCCA Registry. Journal of Hepatology, 76, pp. 1109-1121. (doi: 10.1016/j.jhep.2021.12.010)

Janse van Rensburg, H. J., Spiliopoulou, P., Siu, L. L. (2022) Circulating biomarkers for therapeutic monitoring of anti-cancer agents. Oncologist, 27, pp. 352-362. (doi: 10.1093/oncolo/oyac047)

Casolino, R., Amato, F., Rae, C., Puttagunta, S., Braconi, C. (2022) Receptor tyrosine kinase co-amplification and benefit from HER2 inhibitors in biliary tract cancers. Journal of Hepatology, 76, pp. 1227-1229. (doi: 10.1016/j.jhep.2022.01.012)

Lawrence, M., Wiesheu, R., Coffelt, S. B. (2022) The duplexity of unconventional T cells in cancer. International Journal of Biochemistry and Cell Biology, 146, (doi: 10.1016/j.biocel.2022.106213)

Rosas, I. O. et al. (2022) Tocilizumab in patients hospitalised with COVID-19 pneumonia: efficacy, safety, viral clearance, and antibody response from a randomised controlled trial (COVACTA) EClinicalMedicine, 47, (doi: 10.1016/j.eclinm.2022.101409)

Spiliopoulou, P., Yang, S.Y. C., Bruce, J. P., Wang, B. X., Berman, H. K., Pugh, T. J., Siu, L. L. (2022) All is not lost: learning from 9p21 loss in cancer. Trends in Immunology, 43, pp. 379-390. (doi: 10.1016/j.it.2022.03.003)

Salji, M. J., Blomme, A., Däbritz, J. H. M., Repiscak, P., Lilla, S., Patel, R., Sumpton, D., Van Den Broek, N. J. F., Daly, R., Zanivan, S., Leung, H. Y. (2022) Multi-omics and pathway analysis identify potential roles for tumour n-acetyl aspartate accumulation in murine models of castration resistant prostate cancer. iScience, 25, (doi: 10.1016/j.isci.2022.104056)

Spiliopoulou, P., Spear, S., Mirza, H., Garner, I., Iyer, N., McGarry, L., Grundland-Freile, F., Cheng, Z., Ennis, D. P., McNamara, S., Natoli, M., Mason, S., Blyth, K., Adams, P. D., Roxburgh, P., Fuchter, M. J., Brown, B., McNeish, I. A. (2022) Dual G9A/EZH2 inhibition stimulates anti-tumour immune response in ovarian high grade serous carcinoma. Molecular Cancer Therapeutics, 21, pp. 522-534. (doi: 10.1158/1535-7163.MCT-21-0743)

Brown, L. C., Graham, J., Fisher, D., Adams, R., Seligmann, J., Seymour, M., Kaplan, R., Yates, E., Parmar, M., Richman, S. D., Quirke, P., Butler, R., Shiu, K., Middleton, G., Samuel, L., Wilson, R. H., Maughan, T. S. (2022) Experiences of running a stratified medicine adaptive platform trial: Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal cancer. Clinical Trials, 19, pp. 146-157. (doi: 10.1177/17407745211069879)

Gómez, V., Galazi, M., Weitsman, G., Monypenny, J., Al-Salemee, F., Barber, P. R., Ng, K., Beatson, R., Szokol, B., Orfi, L., Mullen, G., Vanhaesebroeck, B., Chowdhury, S., Leung, H. Y., Ng, T. (2022) HER2 mediates PSMA/mGluR1-driven resistance to the DS-7423 dual PI3K/mTOR inhibitor in PTEN wild-type prostate cancer models. Molecular Cancer Therapeutics, 21, pp. 667-676. (doi: 10.1158/1535-7163.mct-21-0320)

Marks, D. I., Clifton-Hadley, L., Copland, M., Hussain, J., Menne, T. F., McMillan, A., Moorman, A. V., Morley, N., Okasha, D., Patel, B., Patrick, P., Potter, M. N., Rowntree, C. J., Kirkwood, A. A., Fielding, A. K. (2022) In-vivo T-cell depleted reduced-intensity conditioned allogeneic haematopoietic stem-cell transplantation for patients with acute lymphoblastic leukaemia in first remission: results from the prospective, single-arm evaluation of the UKALL14 trial. Lancet Haematology, 9, pp. e276-e288. (doi: 10.1016/S2352-3026(22)00036-9)

Hatthakarnkul, P., Quinn, J. A., Ammar, A., Lynch, G., Van Wyk, H., McMillan, D. C., Thuwajit, C., Edwards, J. (2022) Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer. Clinical Science, 136, pp. 521-535. (doi: 10.1042/CS20210886)

Gaba, F., Tipping, W. J., Salji, M., Faulds, K., Graham, D., Leung, H. Y. (2022) Raman spectroscopy in prostate cancer: techniques, applications and advancements. Cancers, 14, (doi: 10.3390/cancers14061535)

Fanfone, D., Wu, Z., Mammi, J., Berthenet, K., Neves, D., Weber, K., Halaburkova, A., Virard, F., Bunel, F., Jamard, C., Hernandez-Vargas, H., Tait, S. W.G., Hennino, A., Ichim, G. (2022) Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness. eLife, 11, (doi: 10.7554/eLife.73150)

Blomme, A. et al. (2022) THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer. EMBO Molecular Medicine, 14, (doi: 10.15252/emmm.202114764)

Glen, C., Tan, Y. Y., Waterston, A., Evans, T. R. J., Jones, R. J., Petrie, M. C., Lang, N. N. (2022) Mechanistic and clinical overview cardiovascular toxicity of BRAF and MEK inhibitors: JACC: CardioOncology state-of-the-art review. JACC: CardioOncology, 4, pp. 1-18. (doi: 10.1016/j.jaccao.2022.01.096)

Malorni, L. et al. (2022) Serum thymidine kinase activity in patients with hormone receptor-positive and HER2-negative metastatic breast cancer treated with palbociclib and fulvestrant. European Journal of Cancer, 164, pp. 39-51. (doi: 10.1016/j.ejca.2021.12.030)

Johnstone, M. S., Burton, P., Kourounis, G., Winter, J., Crighton, E., Mansouri, D., Witherspoon, P., Smith, K., McSorley, S. T. (2022) Combining the quantitative faecal immunochemical test and full blood count reliably rules out colorectal cancer in a symptomatic patient referral pathway. International Journal of Colorectal Disease, 37, pp. 457-466. (doi: 10.1007/s00384-021-04079-2)

Copland, M., Slade, D., McIlroy, G., Horne, G., Byrne, J. L., Rothwell, K., Brock, K., De Lavallade, H., Craddock, C., Clark, R. E., Smith, M. L., Fletcher, R., Bishop, R., Milojkovic, D., Yap, C. (2022) Ponatinib with fludarabine, cytarabine, idarubicin, and granulocyte colony-stimulating factor chemotherapy for patients with blast-phase chronic myeloid leukaemia (MATCHPOINT): a single-arm, multicentre, phase 1/2 trial. Lancet Haematology, 9, pp. e121-e132. (doi: 10.1016/S2352-3026(21)00370-7)

Quinn, T. M. et al. (2022) Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics. EBioMedicine, 76, (doi: 10.1016/j.ebiom.2022.103856)

Adam, C., Bray, T. L., Pérez-López, A. M., Tan, E. H., Rubio-Ruiz, B., Baillache, D. J., Houston, D. R., Salji, M. J., Leung, H. Y., Unciti-Broceta, A. (2022) A 5-FU precursor designed to evade anabolic and catabolic drug pathways and activated by Pd chemistry in vitro and in vivo. Journal of Medicinal Chemistry, 65, pp. 552-561. (doi: 10.1021/acs.jmedchem.1c01733)

Dreyer, S. B., Upstill-Goddard, R., Legrini, A., Biankin, A. V., Jamieson, N. B., Chang, D. K. (2022) Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence. Gastroenterology, 162, pp. 320-324.e4. (doi: 10.1053/j.gastro.2021.09.022)

de Beauchamp, L., Himonas, E., Helgason, G. V. (2022) Mitochondrial metabolism as a potential therapeutic target in myeloid leukaemia. Leukemia, 36, pp. 1-12. (doi: 10.1038/s41375-021-01416-w)

Paterson, K., Paterson, S., Mulholland, T., Coffelt, S.B., Zagnoni, M. (2022) Assessment of CAR-T mediated and targeted cytotoxicity in 3D microfluidic TBNC co-culture models for combination therapy. IEEE Open Journal of Engineering in Medicine and Biology, 3, pp. 86-95. (doi: 10.1109/OJEMB.2022.3178302)

Dreyer, S., Upstill-Goddard, R., Legrini, A., Biankin, A., Jamieson, N., Chang, D. (2022) Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence. (doi: 10.1016/j.hpb.2022.05.086)

Curio, S., Edwards, S. C., Suzuki, T., McGovern, J., Triulzi, C., Yoshida, N., Jonsson, G., Glauner, T., Rami, D., Wiesheu, R., Kilbey, A., Purcell, R. V., Coffelt, S. B., Guerra, N. (2022) NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression. Discovery Immunology, 1, (doi: 10.1093/discim/kyac002)

Love, S. B. et al. (2022) Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units. Trials, 23, (doi: 10.1186/s13063-022-06680-4)

Dennis, M., Thomas, I. F., Ariti, C., Upton, L., Burnett, A. K., Gilkes, A., Radia, R., Hemmaway, C., Mehta, P., Knapper, S., Clark, R. E., Copland, M., Russell, N., Hills, R. K. (2021) Randomised evaluation of quizartinib and low-dose ara-C vs low-dose ara-C in older acute myeloid leukemia patients. Blood Advances, 5, pp. 5621-5625. (doi: 10.1182/bloodadvances.2021005038)

Mackie, G. M., Copland, A., Takahashi, M., Nakanishi, Y., Everard, I., Kato, T., Oda, H., Kanaya, T., Ohno, H., Maslowski, K. M. (2021) Bacterial cancer therapy in autochthonous colorectal cancer affects tumor growth and metabolic landscape. JCI Insight, 6, (doi: 10.1172/jci.insight.139900)

Rabas, N., Palmer, S., Mitchell, L., Ismail, S., Gohlke, A., Riley, J. S., Tait, S. W.G., Gammage, P., Lemgruber Soares, L., MacPherson, I. R., Norman, J. C. (2021) PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness. Journal of Cell Biology, 220, (doi: 10.1083/jcb.202006049)

Falcomata, C. et al. (2021) Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer. Cancer Discovery, 11, pp. 3158-3177. (doi: 10.1158/2159-8290.CD-21-0209)

van Winsen, M., McSorley, S. T., McLeod, R., MacDonald, A., Forshaw, M. J., Shaw, M., Puxty, K. (2021) Postoperative C-reactive protein concentrations to predict infective complications following gastrectomy for cancer. Journal of Surgical Oncology, 124, pp. 1060-1069. (doi: 10.1002/jso.26613)

Gray, E., Figueroa, J.D., Oikonomidou, O., MacPherson, I., Urquhart, G., Cameron, D.A., Hall, P.S. (2021) Variation in chemotherapy prescribing rates and mortality in early breast cancer over two decades: a national data linkage study. ESMO Open, 6, (doi: 10.1016/j.esmoop.2021.100331)

McPeake, J., Shaw, M., Mactavish, P., Blyth, K., Devine, H., Fleming, G., Gemmell, L., Griffin, J., Grose, P., Henderson, P., Hogg, L., King, K., McInnes, I., O'Brien, P., Puxty, K., Rainey, C., Sharma, V., Sim, M., Strachan, L., Siebert, S., Quasim, T. (2021) Long-term outcomes following severe COVID-19 infection: a multicentre cohort study of family member outcomes. Annals of the American Thoracic Society, 18, pp. 2098-2101. (doi: 10.1513/AnnalsATS.202104-481RL)

Johnson, S. A., Ormsby, M. J., Wessel, H., Hulme, H., Bravo-Blas, A., McIntosh, A., Mason, S., Coffelt, S., Tait, S. W.G., Mcl. Mowat, A., Milling, S., Blyth, K., Wall, D. M. (2021) Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model. European Journal of Immunology, 51, pp. 3228-3238. (doi: 10.1002/eji.202048913)

Rice, S., Jackson, T., Crump, N. T., Fordham, N., Elliott, N., O'Byrne, S., del Mar Lara Fanego, M., Addy, D., Crabb, T., Dryden, C., Inglott, S., Ladon, D., Wright, G., Bartram, J., Ancliff, P., Mead, A. J., Halsey, C., Roberts, I., Milne, T. A., Roy, A. (2021) A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program. Nature Communications, 12, (doi: 10.1038/s41467-021-27270-z)

Malouf, C., Antunes, E. T.B., O'Dwyer, M., Jakobczyk, H., Sahm, F., Landua, S.-L., Anderson, R. A., Soufi, A., Halsey, C., Ottersbach, K. (2021) MiR-130b and miR-128a are essential lineage-specific co-drivers of t(4;11) MLL-AF4 acute leukemia. Blood, 138, pp. 2066-2092. (doi: 10.1182/blood.2020006610)

Hollis, R. L., Stillie, L. J., Hopkins, S., Bartos, C., Churchman, M., Rye, T., Nussey, F., Fegan, S., Nirsimloo, R., Inman, G. J., Herrington, C. S., Gourley, C. (2021) Clinicopathological determinants of recurrence risk and survival in mucinous ovarian carcinoma. Cancers, 13, (doi: 10.3390/cancers13225839)

Adams, R. A., Fisher, D. J., Graham, J., Seligmann, J. F., Seymour, M., Kaplan, R., Yates, E., Parmar, M., Richman, S. D., Quirke, P., Butler, R., Brown, E., Collinson, F., Falk, S., Wasan, H., Shiu, K.-K., Middleton, G., Samuel, L., Wilson, R. H., Brown, L. C., Maughan, T. S. (2021) Capecitabine versus active monitoring in stable or responding metastatic colorectal cancer after 16 weeks of first-line therapy: results of the randomized FOCUS4-N trial. Journal of Clinical Oncology, 39, pp. 3693-3704. (doi: 10.1200/JCO.21.01436)

Carotenuto, P. et al. (2021) Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage. Nature Communications, 12, (doi: 10.1038/s41467-021-27099-6)

Bock, F. J., Sedov, E., Koren, E., Koessinger, A. L., Cloix, C., Zerbst, D., Athineos, D., Anand, J., Campbell, K. J., Blyth, K., Fuchs, Y., Tait, S. W.G. (2021) Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death. Nature Communications, 12, (doi: 10.1038/s41467-021-26613-0)

Zanetti, C. et al. (2021) The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukemia progression via CXCR5-CXCL13. Blood, 138, pp. 1870-1884. (doi: 10.1182/blood.2021011557)

Elliot, T. A.E., Jennings, E. K., Lecky, D. A.J., Natash, N., Flores-Langarica, A., Copland, A., Maslowski, K. M., Wraith, D. C., Bending, D. (2021) Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength. Immunity, 54, pp. 2481-2496.e6. (doi: 10.1016/j.immuni.2021.08.020)

Berry, C. et al. (2021) Post-COVID-19 illness trajectory: a multisystem investigation [Pre-print] Research Square, (doi: 10.21203/rs.3.rs-1053331/v1)

Asciak, R., Kanellakis, N. I., Bibby, A., Kidd, A., Gerry, S., Mercer, R., Maskell, N., Blyth, K. G., Fsadni, P., Montefort, S., Psallidas, I., Rahman, N. M. (2021) The association between pleural fluid exposure and survival in pleural mesothelioma. Chest, 160, pp. 1925-1933. (doi: 10.1016/j.chest.2021.05.063)

Birch, J., Strathdee, K., Stevenson, K., Derby, S., Dutton, L., Clough, E., Koessinger, A., Gilmour, L., McGhee, E., McGarrity-Cottrell, C., Dibekeme, A. a., Collis, S., Rominiyi, O., Lembruber Soares, L., Solecki, G., Winkler, F., Carlin, L., Inman, G., Chalmers, A., Norman, J., Carruthers, R. (2021) Inhibition of ATR prevents macropinocytosis driven retraction of neurites and opposes invasion in GBM. Research Square, (doi: 10.21203/rs.3.rs-967109/v1)

Murphy, K. J. et al. (2021) Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status. Science Advances, 7, (doi: 10.1126/sciadv.abh0363)

Lampis, A., Hahne, J. C., Gasparini, P., Cascione, L., Hedayat, S., Vlachogiannis, G., Murgia, C., Fontana, E., Edwards, J., Horgan, P. G., Terracciano, L., Sansom, O. J., Martins, C. D., Kramer-Marek, G., Croce, C. M., Braconi, C., Fassan, M., Valeri, N. (2021) MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer. Cell Death and Differentiation, 28, pp. 2970-2982. (doi: 10.1038/s41418-021-00820-0)

Turner, N. C. et al. (2021) Niraparib for advanced breast cancer with germline BRCA1 and BRCA2 mutations: the EORTC 1307-BCG/BIG5-13/TESARO PR-30-50-10-C BRAVO study. Clinical Cancer Research, 27, pp. 5482-5491. (doi: 10.1158/1078-0432.CCR-21-0310)

Tsim, S. et al. (2021) Serum proteomics and plasma fibulin-3 in differentiation of mesothelioma from asbestos-exposed controls and patients with other pleural diseases. Journal of Thoracic Oncology, 16, pp. 1705-1717. (doi: 10.1016/j.jtho.2021.05.018)

Ianniciello, A., Zarou, M. M., Rattigan, K. M., Scott, M., Dawson, A., Dunn, K., Brabcova, Z., Kalkman, E. R., Nixon, C., Michie, A. M., Copland, M., Vetrie, D., Ambler, M., Saxty, B., Helgason, G. V. (2021) ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy. Science Translational Medicine, 13, (doi: 10.1126/scitranslmed.abd5016)

Ianniciello, A., Helgason, G. V. (2021) Autophagy in hematopoiesis and leukemogenesis. Academic Press

Campbell, K. J., Mason, S. M., Winder, M. L., Willemsen, R. B.E., Cloix, C., Lawson, H., Rooney, N., Dhayade, S., Sims, A. H., Blyth, K., Tait, S. W.G. (2021) Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function. Cell Death and Differentiation, 28, pp. 2589-2600. (doi: 10.1038/s41418-021-00773-4)

Chan, B. Y.L., McKinlay, S., Forshaw, M., Macdonald, A., Maitra, R., Orizu, M., McSorley, S. T. (2021) Impact of anaemia in oesophago-gastric cancer patients undergoing curative treatment by means of neoadjuvant chemotherapy and surgery. Surgical Oncology, 38, (doi: 10.1016/j.suronc.2021.101585)

Aung, M. M. K., Mills, M. L., Bittencourt-Silvestre, J., Keeshan, K. (2021) Insights into the molecular profiles of adult and paediatric acute myeloid leukaemia. Molecular Oncology, 15, pp. 2253-2272. (doi: 10.1002/1878-0261.12899)

Finn, R. S., Kudo, M., Cheng, A.-L., Wyrwicz, L., Ngan, R. K.C., Blanc, J.-F., Baron, A. D., Vogel, A., Ikeda, M., Piscaglia, F., Han, K.-H., Qin, S., Minoshima, Y., Kanekiyo, M., Ren, M., Dairiki, R., Tamai, T., Dutcus, C. E., Ikezawa, H., Funahashi, Y., Evans, T. R. J. (2021) Pharmacodynamic biomarkers predictive of survival benefit with lenvatinib in unresectable hepatocellular carcinoma: from the phase III REFLECT study. Clinical Cancer Research, 27, pp. 4848-4858. (doi: 10.1158/1078-0432.CCR-20-4219)

Stonier, T. et al. (2021) The "Is mpMRI Enough" or IMRIE Study: a multicentre evaluation of prebiopsy multiparametric magnetic resonance imaging compared with biopsy. European Urology Focus, 7, pp. 1027-1034. (doi: 10.1016/j.euf.2020.09.012)

Hanna, C. R., O'Cathail, S. M., Graham, J. S., Saunders, M., Samuel, L., Harrison, M., Devlin, L., Edwards, J., Gaya, D. R., Kelly, C. A., Lewsley, L.-A., Maka, N., Morrison, P., Dinnett, L., Dillon, S., Gourlay, J., Platt, J. J., Thomson, F., Adams, R. A., Roxburgh, C. S.D. (2021) Durvalumab (MEDI 4736) in combination with extended neoadjuvant regimens in rectal cancer: a study protocol of a randomised phase II trial (PRIME-RT) Radiation Oncology, 16, (doi: 10.1186/s13014-021-01888-1)

Middleton, M. R., Dean, E., Evans, T. R.J., Shapiro, G. I., Pollard, J., Hendriks, B. S., Falk, M., Diaz-Padilla, I., Plummer, R. (2021) Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours. British Journal of Cancer, 125, pp. 510-519. (doi: 10.1038/s41416-021-01405-x)

Marini, A. et al. (2021) The pathogenesis of mesothelioma is driven by a dysregulated translatome. Nature Communications, 12, (doi: 10.1038/s41467-021-25173-7)

Casolino, R., Paiella, S., Azzolina, D., Beer, P. A., Corbo, V., Lorenzoni, G., Gregori, D., GOlan, T., Braconi, C., Froeling, F. E.M., Milella, M., Scarpa, A., Pea, A., Malleo, G., Salvia, R., Bassi, C., Chang, D. K., Biankin, A. V. (2021) Homologous recombination deficiency in pancreatic cancer: a systematic review and prevalence meta-analysis. Journal of Clinical Oncology, 39, pp. 2617-2631. (doi: 10.1200/JCO.20.03238)

Johnstone, M. S., Lynch, G., Park, J., McSorley, S., Edwards, J. (2021) Novel methods of risk stratifying patients for metachronous, pre-malignant colorectal polyps: a systematic review. Critical Reviews in Oncology/Haematology, 164, (doi: 10.1016/j.critrevonc.2021.103421)

Peddie, N., Agnew, S., Crawford, M., Dixon, D., MacPherson, I., Fleming, L. (2021) The impact of medication side effects on adherence and persistence to hormone therapy in breast cancer survivors: a qualitative systematic review and thematic synthesis. Breast, 58, pp. 147-159. (doi: 10.1016/j.breast.2021.05.005)

Halsey, C., Escherich, G. (2021) A “Goldilocks” approach to CNS leukaemia is needed. Blood, 138, pp. 288-289. (doi: 10.1182/blood.2021011461)

Spiliopoulou, P., Hinsley, S., Mcneish, I. A., Roxburgh, P., Glasspool, R. (2021) Metronomic oral cyclophosphamide in relapsed ovarian cancer. International Journal of Gynecological Cancer, 31, pp. 1037-1044. (doi: 10.1136/ijgc-2021-002467)

Lei, M., Siemers, N. O., Pandya, D., Chang, H., Sanchez, T., Harbison, C., Szabo, P. M., Janjigian, Y., Ott, P. A., Sharma, P., Bendell, J., Evans, T. R. J., de Braud, F., Chau, I., Boyd1, Z. (2021) Analyses of PD-L1 and inflammatory gene expression association with efficacy of nivolumab±Ipilimumab in gastric cancer/gastroesophageal junction cancer. Clinical Cancer Research, 27, pp. 3926-3935. (doi: 10.1158/1078-0432.CCR-20-2790)

Ntala, C., Salji, M., Salmond, J., Officer, L., Teodosio, A. V., Blomme, A., McGhee, E. J., Powley, I., Ahmad, I., Kruithof-de Julio, M., Thalmann, G., Roberts, E., Goodyear, C. S., Jamaspishvili, T., Berman, D. M., Carlin, L. M., Le Quesne, J., Leung, H. Y. (2021) Analysis of prostate cancer tumor microenvironment identifies reduced stromal CD4 effector T-cell infiltration in tumors with pelvic nodal metastasis. European Urology Open Science, 29, pp. 19-29. (doi: 10.1016/j.euros.2021.05.001)

Haq, M. I., Drake, T. M., Goh, T. L., Ahmed, A., Forrest, E., Barclay, S., Gillespie, R., Priest, M., Evans, J., Graham, J., Ballantyne, S., McMillan, D. C., Hayes, P. C., Bird, T. G., Stanley, A. J. (2021) Effect of hepatocellular carcinoma surveillance programmes on overall survival in a mixed cirrhotic UK population: a prospective, longitudinal cohort study. Journal of Clinical Medicine, 10, (doi: 10.3390/jcm10132770)

Welisch, G., Twelves, C., Plummer, R., Evans, J., Danson, S., Symeonides, S., Halsey, C., Jones, R., Hanna, C., Gallagher, P., Walls, G., Taylor, K., Barnett, S., Forde, C., White, M., Williams, C., El Badri, S., Chipole, B.'e. D., Keith, N. (2021) First in Human: who and what makes a cancer phase 1 trial and why are they so important? (doi: 10.17605/OSF.IO/KWHQF)

Martinez, R. S., Salji, M. J., Rushworth, L., Ntala, C., Rodriguez Blanco, G., Hedley, A., Clark, W., Peixoto, P., Hervouet, E., Renaude, E., Kung, S. H. Y., Galbraith, L. C.A., Nixon, C., Lilla, S., Mackay, G. M., Fazli, L., Gaughan, L., Sumpton, D., Gleave, M. E., Zanivan, S., Blomme, A., Leung, H. Y. (2021) SLFN5 regulates LAT1-mediated mTOR activation in castration-resistant prostate cancer. Cancer Research, 81, pp. 3664-3678. (doi: 10.1158/0008-5472.CAN-20-3694)

Andrés-Jensen, L. et al. (2021) Severe toxicity free survival: physician-derived definitions of unacceptable long-term toxicities following acute lymphocytic leukaemia. Lancet Haematology, 8, pp. e513-e523. (doi: 10.1016/S2352-3026(21)00136-8)

Galbraith, N. J., Wood, C., Steele, C. W. (2021) Targeting metastatic colorectal cancer with immune oncological therapies. Cancers, 13, (doi: 10.3390/cancers13143566)

Mansouri, D., McSorley, S. T., Park, J. H., Orange, C., Horgan, P. G., McMillan, D. C., Edwards, J. (2021) The inflammatory microenvironment in screen-detected premaligant adenomatous polyps: early results from the integrated technologies for improved polyp surveillance (INCISE) project. European Journal of Gastroenterology and Hepatology, 33, pp. 983-989. (doi: 10.1097/MEG.0000000000002202)

Matly, A., Quinn, J. A., McMillan, D. C., Park, J. H., Edwards, J. (2021) The relationship between β-catenin and patient survival in colorectal cancer systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 163, (doi: 10.1016/j.critrevonc.2021.103337)

McSorley, S. T., Digby, J., Clyde, D., Cruickshank, N., Burton, P., Barker, L., Strachan, J. A., Fraser, C. G., Smith, K., Mowat, C., Winter, J., Steele, R. J.C. (2021) Yield of colorectal cancer at colonoscopy according to faecal haemoglobin concentration in symptomatic patients referred from primary care. Colorectal Disease, 23, pp. 1615-1621. (doi: 10.1111/codi.15405)

Paterson, K., Zanivan, S., Glasspool, R., Coffelt, S.B., Zagnoni, M. (2021) Microfluidic technologies for immunotherapy studies on solid tumours. Lab on a Chip, 21, pp. 2306-2329. (doi: 10.1039/D0LC01305F)

Koessinger, A. L., Koessinger, D., Kinch, K., Martínez-Escardó, L., Paul, N. R., Elmasry, Y., Malviya, G., Cloix, C., Campbell, K. J., Bock, F. J., O'Prey, J., Stevenson, K., Nixon, C., Jackson, M. R., Ichim, G., Stewart, W., Blyth, K., Ryan, K. M., Chalmers, A. J., Norman, J. C., Tait, S. W.G. (2021) Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics. bioRxiv, (doi: 10.1101/2021.06.13.448232)

Chantkran, W., Hsieh, Y.-C., Zheleva, D., Frame, S., Wheadon, H., Copland, M. (2021) Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML. Cell Death Discovery, 7, (doi: 10.1038/s41420-021-00496-y)

Leach, J. D.G. et al. (2021) Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis. Nature Communications, 12, (doi: 10.1038/s41467-021-23717-5)

Nielsen, S. R., Strøbech, J. E., Horton, E. R., Jackstadt, R., Laitala, A., Bravo, M. C., Maltese, G., Jensen, A. R. D., Reuten, R., Rafaeva, M., Karim, S. A., Hwang, C.-I., Arnes, L., Tuveson, D. A., Sansom, O. J., Morton, J. P., Erler, J. T. (2021) Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade. Nature Communications, 12, (doi: 10.1038/s41467-021-23731-7)

Palmieri, C., MacPherson, I. R. (2021) A review of the evidence base for utilizing Child-Pugh criteria for guiding dosing of anticancer drugs in patients with cancer and liver impairment. ESMO Open, 6, (doi: 10.1016/j.esmoop.2021.100162)

Zarou, M.-M., Vazquez, A., Helgason, G. V. (2021) Folate metabolism: a re-emerging therapeutic target in haematological cancers. Leukemia, 35, pp. 1539-1551. (doi: 10.1038/s41375-021-01189-2)

Cangiano, M., Grudniewska, M., Salji, M. J., Nykter, M., Jenster, G., Urbanucci, A., Grabcgu, Z., Janssen, B., Hamilton, G., Leung, H. Y., Beumer, I. J. (2021) Gene regulation network analysis on human prostate orthografts highlights a potential role for the JMJD6 regulon in clinical prostate cancer. Cancers, 13, (doi: 10.3390/cancers13092094)

Hsieh, Y.-C., Kirschner, K., Copland, M. (2021) Improving outcomes in chronic myeloid leukemia through harnessing the immunological landscape. Leukemia, 35, pp. 1229-1242. (doi: 10.1038/s41375-021-01238-w)

Knight, J. R.P. et al. (2021) MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discovery, 11, pp. 1228-1247. (doi: 10.1158/2159-8290.CD-20-0652)

Moreno, R., Banerjee, S., Jackson, A. W., Quinn, J., Baillie, G., Dixon, J. E., Dinkova-Kostova, A. T., Edwards, J., de la Vega, L. (2021) The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress. Cell Death and Differentiation, 28, pp. 1563-1578. (doi: 10.1038/s41418-020-00686-8)

Kingston, B., Cutts, R. J., Bye, H., Beaney, M., Walsh-Crestani, G., Hrebien, S., Swift, C., Kilburn, L. S., Kernaghan, S., Moretti, L., Wilkinson, K., Wardley, A. M., Macpherson, I. R., Baird, R. D., Roylance, R., Reis-Filho, J. S., Hubank, M., Faull, I., Banks, K. C., Lanman, R. B., Garcia-Murillas, I., Bliss, J. M., Ring, A., Turner, N. C. (2021) Genomic profile of advanced breast cancer in circulating tumour DNA. Nature Communications, 12, (doi: 10.1038/s41467-021-22605-2)

Galbraith, L. C.A., Mui, E., Nixon, C., Hedley, A., Strachan, D., MacKay, G., Sumpton, D., Sansom, O. J., Leung, H. Y., Ahmad, I. (2021) PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer. Oncogene, 40, pp. 2355-2366. (doi: 10.1038/s41388-021-01707-7)

McNamara, M. G., Bridgewater, J., Palmer, D.H., Faluyi, O., Wasan, H., Patel, A., Ryder, W.D., Barber, S., Gnanaranjan, C., Ghazaly, E., Evans, T.R.J., Valle, J.W. (2021) A phase Ib study of NUC-1031 in combination with cisplatin for the first-line treatment of patients with advanced biliary tract cancer (ABC-08) Oncologist, 26, pp. e669-e678. (doi: 10.1002/onco.13598)

Mooney, L., Goodyear, C. S., Chandra, T., Kirschner, K., Copland, M., Petrie, M. C., Lang, N. N. (2021) Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure. Clinical Science, 135, pp. 991-1007. (doi: 10.1042/CS20200306)

Roca-Portoles, A., Tait, S. W.G. (2021) Mitochondrial quality control: from molecule to organelle. Cellular and Molecular Life Sciences, 78, pp. 3853-3866. (doi: 10.1007/s00018-021-03775-0)

Rae, C., Amato, F., Braconi, C. (2021) Patient-derived organoids as a model for cancer drug discovery. International Journal of Molecular Sciences, 22, (doi: 10.3390/ijms22073483)

Shi, Y., Beckett, M. C., Blair, H. J., Tirtakusuma, R., Nakjang, S., Enshaei, A., Halsey, C., Vormoor, J., Heidenreich, O., Krippner-Heidenreich, A., van Delft, F. W. (2021) Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia. Haematologica, 106, pp. 1056-1066. (doi: 10.3324/haematol.2019.241026)

Macpherson, I. R., He, Y., Palmieri, C. (2021) Eribulin, Child-Pugh score, and liver-function tests: lessons from pivotal breast cancer studies 301 and 305. Breast Cancer Research, 23, (doi: 10.1186/s13058-021-01407-w)

Hanna, C. R., Robb, K. A., Blyth, K. G., Jones, R. J., Chalmers, A. J. (2021) Clinician attitudes to using low dose radiotherapy to treat COVID-19 lung disease. International Journal of Radiation Oncology, Biology, Physics, 109, pp. 886-890. (doi: 10.1016/j.ijrobp.2020.12.003)

McFarlane, A. J., Fercoq, F., Coffelt, S. B., Carlin, L. M. (2021) Neutrophil dynamics in the tumor microenvironment. Journal of Clinical Investigation, 131, (doi: 10.1172/JCI143759)

Nacke, M., Sandilands, E., Nikolatou, K., Román-Fernández, Á., Mason, S., Patel, R., Lilla, S., Yelland, T., Galbraith, L. C.A., Freckmann, E. C., McGarry, L., Morton, J. P., Shanks, E., Leung, H. Y., Markert, E., Ismail, S., Zanivan, S., Blyth, K., Bryant, D. M. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, (doi: 10.1038/s41467-021-21847-4)

Annese, V. F., Patil, S. B., Hu, C., Giagkoulovits, C., Al-Rawhani, M. A., Grant, J., Macleod, M., Clayton, D.J., Heaney, L.M., Daly, R., Accarino, C., Shah, Y. D., Cheah, B. C., Beeley, J., Evans, T.R.J., Jones, R., Barrett, M. P., Cumming, D. R.S. (2021) A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection. Microsystems and Nanoengineering, 7, (doi: 10.1038/s41378-021-00243-4)

Al-Badran, S. S.F., Grant, L., Campo, M. B., Inthagard, J., Pennel, K., Quinn, J., Konanahalli, P., Hayman, L., Horgan, P. G., McMillan, D. C., Roxburgh, C. S.D., Roseweir, A., Park, J. H., Edwards, J. (2021) Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 7, pp. 121-134. (doi: 10.1002/cjp2.193)

Yun, S., Vincelette, N. D., Yu, X., Watson, G. W., Fernandez, M. R., Yang, C., Hitosugi, T., Cheng, C.-H., Freischel, A. R., Zhang, L., Li, W., Hou, H., Schaub, F. X., Vedder, A. R., Cen, L., McGraw, K. L., Moon, J., Murphy, D. J., Ballabio, A., Kaufmann, S. H., Berglund, A. E., Cleveland, J. L. (2021) TFEB links MYC signaling to epigenetic control of myeloid differentiation and acute myeloid leukemia. Blood Cancer Discovery, 2, pp. 162-185. (doi: 10.1158/2643-3230.bcd-20-0029)

Shamis, S. A. K., McMillan, D. C., Edwards, J. (2021) The relationship between Hypoxia-inducible factor 1α (HIF-1α) and patient survival in breast cancer: systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 159, (doi: 10.1016/j.critrevonc.2021.103231)

Laskar, P., Somani, S., Mullin, M., Tate, R. J., Warzecha, M., Bowering, D., Keating, P., Irving, C., Leung, H. Y., Dufès, C. (2021) Octadecyl chain-bearing PEGylated poly(propyleneimine)-based dendrimersomes: physicochemical studies, redox-responsiveness, DNA condensation, cytotoxicity and gene delivery to cancer cells. Biomaterials Science, 9, pp. 1431-1448. (doi: 10.1039/D0BM01441A)

Race, A. M., Sutton, D., Hamm, G., Maglennon, G., Morton, J. P., Strittmatter, N., Campbell, A., Sansom, O. J., Wang, Y., Barry, S. T., Takáts, Z., Goodwin, R. J.A., Bunch, J. (2021) Deep learning-based annotation transfer between molecular imaging modalities: an automated workflow for multimodal data integration. Analytical Chemistry, 93, pp. 3061-3071. (doi: 10.1021/acs.analchem.0c02726)

Keith, N., Plummer, R., Coyle, V., Cameron, D., Evans, J., Twelves, C., Palmer, D., Danson, S., Graham, D., Welisch, G. (2021) Early Phase Cancer Research in the COVID-19 Pandemic: an ECMC North Initiative. (doi: 10.17605/OSF.IO/6WTN2)

Casolino, R., Braconi, C., Malleo, G., Paiella, S., Bassi, C., Milella, M., Dreyer, S.B., Froeling, F.E.M., Chang, D.K., Biankin, A.V., Golan, T. (2021) Reshaping preoperative treatment of pancreatic cancer in the era of precision medicine. Annals of Oncology, 32, pp. 183-196. (doi: 10.1016/j.annonc.2020.11.013)

Hartley, A., Leung, H. Y., Ahmad, I. (2021) Targeting the BAF complex in advanced prostate cancer. Expert Opinion on Drug Discovery, 16, pp. 173-181. (doi: 10.1080/17460441.2020.1821644)

McSorley, S. T., Steele, C. W., Anderson, J. H., McKinlay, S. (2021) Comment on 'Preoperative intravenous iron therapy and survival after colorectal cancer surgery: long term results from the IVICA randomised controlled trial' Colorectal Disease, 23, pp. 555-556. (doi: 10.1111/codi.15428)

McSorley, S. T., Lau, H. Y.N., McIntosh, D., Forshaw, M. J., McMillan, D. C., Crumley, A. B. (2021) Staging the tumour and staging the host: Pre-treatment combined Neutrophil Lymphocyte Ratio and modified Glasgow Prognostic Score is associated with overall survival in patients with oesophagogastric cancers undergoing treatment with curative intent. Annals of Surgical Oncology, 28, pp. 722-731. (doi: 10.1245/s10434-020-09074-5)

Lenk, L., Carlet, M., Vogiatzi, F., Spory, L., Winterberg, D., Cousins, A., Vossen-Gajcy, M., Ibruli, O., Vokuhl, C., Cario, G., El Ayoubi, O., Kramer, L., Ritgen, M., Brüggemann, M., Häsler, R., Schrappe, M., Fuhrmann, S., Halsey, C., Jeremias, I., Hobeika, E., Jumaa, H., Alsadeq, A., Schewe, D. M. (2021) CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia. Communications Biology, 4, (doi: 10.1038/s42003-020-01591-z)

Alhayyan, A. M., McSorley, S. T., Kearns, R. J., Horgan, P. G., Roxburgh, C. S.D., McMillan, D. C. (2021) The effect of anesthesia on the magnitude of the postoperative systemic inflammatory response in patients undergoing elective surgery for colorectal cancer in the context of an enhanced recovery pathway: A prospective cohort study. Medicine, 100, (doi: 10.1097/MD.0000000000023997)

Latif, A.-L. et al. (2021) BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 12, (doi: 10.1038/s41467-020-20378-8)

Keeshan, K. (2021) Superenhancing AML with Trib1. Blood, 137, pp. 8-9. (doi: 10.1182/blood.2020008315)

Edwards, S. C., Hoevenaar, W. H.M., Coffelt, S. B. (2021) Emerging immunotherapies for metastasis. British Journal of Cancer, 124, pp. 37-48. (doi: 10.1038/s41416-020-01160-5)

Dreyer, S. B. et al. (2021) Targeting DNA damage response and replication stress in pancreatic cancer. Gastroenterology, 160, pp. 362-377. (doi: 10.1053/j.gastro.2020.09.043)

Pea, A., Jamieson, N. B., Braconi, C. (2021) Biology and clinical application of regulatory RNAs in hepatocellular carcinoma. Hepatology, 73, pp. 38-48. (doi: 10.1002/hep.31225)

Froeling, F. E.M., Casolino, R., Pea, A., Biankin, A. V., Chang, D. K. (2021) Molecular subtyping and precision medicine for pancreatic cancer. Journal of Clinical Medicine, 10, (doi: 10.3390/jcm10010149)

Earl, H.M., Hiller, L., Dunn, J., Macpherson, I., Rea, D., Hughes-Davies, L., McAdam, K., Hall, P., Mansi, J., Wheatley, D., Abraham, J.E., Caldas, C., Gasson, S., O'Riordan, E., Wilcox, M., Miles, D., Cameron, D.A., Wardley, A. (2021) Optimising the duration of adjuvant trastuzumab in early breast cancer in the UK. Clinical Oncology, 33, pp. 15-19. (doi: 10.1016/j.clon.2020.07.006)

Ofoeyeno, N., Ekpenyong, E., Braconi, C. (2021) Pathogenetic role and clinical implications of regulatory RNAs in biliary tract cancer. Cancers, 13, (doi: 10.3390/cancers13010012)

Marensi, V., Keeshan, K. R., MacEwan, D. J. (2021) Pharmacological impact of FLT3 mutations on receptor activity and responsiveness to tyrosine kinase inhibitors. Biochemical Pharmacology, 183, (doi: 10.1016/j.bcp.2020.114348)

Pascual, J. et al. (2021) Triplet therapy with palbociclib, taselisib and fulvestrant in PIK3CA mutant breast cancer and doublet palbociclib and taselisib in pathway mutant solid cancers. Cancer Discovery, 11, pp. 92-107. (doi: 10.1158/2159-8290.CD-20-0553)

Hanna, C. R., Boyd, K. A., Wincenciak, J., Graham, J., Iveson, T., Jones, R. J., Wilson, R. (2021) Do clinical trials change practice? A longitudinal, international assessment of colorectal cancer prescribing practices. Cancer Treatment and Research Communications, 28, (doi: 10.1016/j.ctarc.2021.100445)

Klionsky, D. J. et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Autophagy, 17, pp. 1-382. (doi: 10.1080/15548627.2020.1797280)

Morton, J. P., Watt, D. M. (2021) Heterogeneity in the pancreatic cancer microenvironment – TGFβ as a master regulator? Cancers, 13, (doi: 10.3390/cancers13194984)

McPeake, J., Shaw, M., Mactavish, P., Blyth, K., Devine, H., Fleming, G., Gemmell, L., Griffin, J., Grose, P., Henderson, M., Henderson, P., Hogg, L., King, K., McInnes, I., O'Brien, P., Puxty, K., Rainey, C., Sharma, V., Sim, M., Strachan, L., Siebert, S., Quasim, T. (2021) Long-term outcomes following severe COVID-19 infection: a propensity matched cohort study. BMJ Open Respiratory Research, 8, (doi: 10.1136/bmjresp-2021-001080)

McMillan, H. D., Keeshan, K., Dunbier, A. K., Mace, P. D. (2021) Structure vs. Function of TRIB1—Myeloid Neoplasms and Beyond. Cancers, 13, (doi: 10.3390/cancers13123060)

Hatthakarnkul, P., Quinn, J. A., Matly, A. A. M., Ammar, A., Van Wyk, H. C., McMillan, D. C., Edwards, J. (2021) Systematic review of tumour budding and association with common mutations in patients with colorectal cancer. Critical Reviews in Oncology/Hematology, 167, (doi: 10.1016/j.critrevonc.2021.103490)

Parry, N., Wheadon, H., Copland, M. (2021) The application of BH3 mimetics in myeloid leukemias. Cell Death and Disease, 12, (doi: 10.1038/s41419-021-03500-6)

Mangion, K. et al. (2020) The Chief Scientist Office cardiovascular and pulmonary imaging in SARS Coronavirus disease-19 (CISCO-19) study. Cardiovascular Research, 116, pp. 2185-2196. (doi: 10.1093/cvr/cvaa209)

Tsim, S., Cowell, G. W., Kidd, A., Woodward, R., Alexander, L., Kelly, C., Foster, J. E., Blyth, K. G. (2020) A comparison between MRI and CT in the assessment of primary tumour volume in mesothelioma. Lung Cancer, 150, pp. 12-20. (doi: 10.1016/j.lungcan.2020.09.025)

McAllister, M. J., McCall, P., Dickson, A., Underwood, M. A., Andersen, D., Holmes, E., Market, E., Leung, H. Y., Edwards, J. (2020) Androgen receptor phosphorylation at serine 81 and serine 213 in castrate-resistant prostate cancer. Prostate Cancer and Prostatic Diseases, 23, pp. 596-606. (doi: 10.1038/s41391-020-0235-1)

Moekotte, A. L., Lof, S., Van Roessel, S., Fontana, M., Dreyer, S., Shablak, A., Casciani, F., Mavroeidis, V. K., Robinson, S., Khalil, K., Gradinariu, G., Mowbray, N., Al-Sarireh, B., Fusai, G. K., Roberts, K., White, S., Soonawalla, Z., Jamieson, N. B., Salvia, R., Besselink, M. G., Abu Hilal, M. (2020) Histopathologic predictors of survival and recurrence in resected ampullary adenocarcinoma. Annals of Surgery, 272, pp. 1086-1093. (doi: 10.1097/SLA.0000000000003177)

Ahmed, A., Tait, S. W.G. (2020) Targeting immunogenic cell death in cancer. Molecular Oncology, 14, pp. 2994-3006. (doi: 10.1002/1878-0261.12851)

Dolan, R. D., Maclay, J. D., Abbass, T., Colville, D., Buali, F., MacLeod, N., McSorley, S. T., Horgan, P. G., McMillan, D. C. (2020) The relationship between 18F-FDG-PETCT-derived tumour metabolic activity, nutritional risk, body composition, systemic inflammation and survival in patients with lung cancer. Scientific Reports, 10, (doi: 10.1038/s41598-020-77269-7)

Malviya, G., Patel, R., Salji, M., Martinez, R. S., Repiscak, P., Mui, E., Champion, S., Mrowinska, A., Johnson, E., AlRasheedi, M., Pimlott, S., Lewis, D., Leung, H. Y. (2020) 18F-Fluciclovine PET metabolic imaging reveals prostate cancer tumour heterogeneity associated with disease resistance to androgen deprivation therapy. EJNMMI Research, 10, (doi: 10.1186/s13550-020-00728-9)

Coffelt, S. B., Kabelitz, D., Silva-Santos, B., Kuball, J., Born, W., Bank, I. (2020) Editorial: γδ T Cells in Cancer. Frontiers in Immunology, 11, (doi: 10.3389/fimmu.2020.602411)

Hanna, C. R., Blyth, K. G., Burley, G., Carmichael, S., Evans, C., Hinsley, S., Khadra, I., Khoo, S., Lewsley, L.-A., Jones, R. R., Sharma, R., Taladriz-Sender, A., Thomson, E. C., Scott, J. T. (2020) Glasgow Early Treatment Arm Favirpiravir (GETAFIX) for adults with early stage COVID-19: A structured summary of a study protocol for a randomised controlled trial. Trials, 21, (doi: 10.1186/s13063-020-04891-1)

Duffy, C., Kidd, A. C., Francis, S., Tsim, S., McNaughton, L., Ferguson, K., Ferguson, J., Rodgers, G., Mcgroarty, C., Sayer, R., Blyth, K. G. (2020) Chest drain aerosol generation in COVID-19 and emission reduction using a simple anti-viral filter. BMJ Open, 7, (doi: 10.1136/bmjresp-2020-000710)

McAllister, M., Constancio, V., Patek, S., Gan, H., Bailey, P., Wheadon, H., Underwood, M., Leung, H., Edwards, J. (2020) Inflammatory infiltration is associated with AR expression and poor prognosis in hormone naïve prostate cancer. Prostate, 80, pp. 1353-1364. (doi: 10.1002/pros.24064)

Suzuki, T., Hayman, L., Kilbey, A., Edwards, J., Coffelt, S. B. (2020) Gut γδ T cells as guardians, disruptors and instigators of cancer. Immunological Reviews, 298, pp. 198-217. (doi: 10.1111/imr.12916)

Stöhr, D., Schmid, J. O., Beigl, T. B., Mack, A., Maichl, D. S., Cao, K., Budai, B., Fullstone, G., Kontermann, R. E., Mürdter, T. E., Tait, S. W.G., Hagenlocher, C., Pollak, N., Scheurich, P., Rehm, M. (2020) Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids. Cell Death and Differentiation, 27, pp. 3037-3052. (doi: 10.1038/s41418-020-0559-3)

Middleton, M. R., McAlpine, C., Woodcock, V. K., Corrie, P., Infante, J. R., Steven, N. M., Evans, T. R. J., Anthoney, A., Shoushtari, A. N., Hamid, O., Gupta, A., Vardeu, A., Leach, E., Naidoo, R., Stanhope, S., Lewis, S., Hurstb, J., O’Kelly, I., Sznol, M. (2020) Tebentafusp, a TCR/anti-CD3 bispecific fusion protein targeting gp100, potently activated antitumor immune responses in patients with metastatic melanoma. Clinical Cancer Research, 26, pp. 5869-5878. (doi: 10.1158/1078-0432.CCR-20-1247)

Savioli, F., Edwards, J., McMillan, D., Stallard, S., Doughty, J., Romics, L. (2020) The effect of postoperative complications on survival and recurrence after surgery for breast cancer: a systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 155, (doi: 10.1016/j.critrevonc.2020.103075)

Kristeleit, R. et al. (2020) Phase 1/2a trial of intravenous BAL101553, a novel controller of the spindle assembly checkpoint, in advanced solid tumours. British Journal of Cancer, 123, pp. 1360-1369. (doi: 10.1038/s41416-020-1010-8)

Dolan, R. D., Alwahid, M., McSorley, S. T., Park, J. H., Stevenson, R. P., Roxburgh, C. S., Horgan, P. G., McMillan, D. C. (2020) A comparison of the prognostic value of composite ratios and cumulative scores in patients with operable rectal cancer. Scientific Reports, 10, (doi: 10.1038/s41598-020-73909-0)

Mevel, R., Steiner, I., Mason, S., Galbraith, L. C.A., Patel, R., Fadlullah, M. Z.H., Ahmad, I., Leung, H. Y., Oliveira, P., Blyth, K., Baena, E., Lacaud, G. (2020) RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development. eLife, 9, (doi: 10.7554/elife.60225)

Alexander, P.G., Roseweir, A.K., Pennel, K.A.F., van Wyk, H.C., Powell, A.G.M.T., McMillan, D.C., Horgan, P.G., Kelly, C., Hay, J., Sansom, O., Harkin, A., Roxburgh, C.S.D., Graham, J., Church, D.N., Tomlinson, I., Saunders, M., Iveson, T.J., Edwards, J., Park, J.H. (2020) The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer. British Journal of Cancer, 124, pp. 786-796. (doi: 10.1038/s41416-020-01168-x)

Montes, M., MacKenzie, L., McAllister, M.J., Roseweir, A., McCall, P., Hatziieremia, S., Underwood, M.A., Boyd, M., Paul, A., Plevin, R., MacKay, S.P., Edwards, J. (2020) Determining the prognostic significance of IKKα in prostate cancer. Prostate, 80, pp. 1188-1202. (doi: 10.1002/pros.24045)

Turner, N. C. et al. (2020) Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial. Lancet Oncology, 21, pp. 1296-1308. (doi: 10.1016/S1470-2045(20)30444-7)

Roseweir, A. K., Park, J. H., ten Hoorn, S., Powell, A. G.M.T., Aherne, S., Roxburgh, C. S.D., McMillan, D. C., Horgan, P. G., Ryan, E., Sheahan, K., Vermeulen, L., Paul, J., Harkin, A., Graham, J., Sansom, O., Church, D. N., Tomlinson, I., Saunders, M., Iveson, T. J., Edwards, J. (2020) Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer. Journal of Pathology: Clinical Research, 6, pp. 283-296. (doi: 10.1002/cjp2.171)

Savino, A. M. et al. (2020) Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on Stearoyl CoA desaturase. Nature Cancer, 1, pp. 998-1009. (doi: 10.1038/s43018-020-00115-2)

Richmond, L., Keeshan, K. (2020) Pseudokinases: a tribble‐edged sword. FEBS Journal, 287, pp. 4170-4182. (doi: 10.1111/febs.15096)

Marin, J. J. G., Prete, M. G., Lamarca, A., Tavolari, S., Landa-Magdalena, A., Brandi, G., Segatto, O., Vogel, A., Macias, R. I. R., Rodrigues, P. M., Casta, A. L., Mertens, J., Rodrigues, C. M. P., Fernandez-Barrena, M. G., Da Silva Ruivo, A., Marzioni, M., Mentrasti, G., Acedo, P., Munoz-Garrido, P., Cardinale, V., Banales, J. M., Valle, J. W., Bridgewater, J., Braconi, C. (2020) Current and novel therapeutic opportunities for systemic therapy in biliary cancer. British Journal of Cancer, 123, pp. 1047-1059. (doi: 10.1038/s41416-020-0987-3)

Torrente, L., Maan, G., Oumkaltoum Rezig, A., Quinn, J., Jackson, A., Grilli, A., Casares, L., Zhang, Y., Kulesskiy, E., Saarela, J., Bicciato, S., Edwards, J., Dinkova-Kostova, A. T., de la Vega, L. (2020) High NRF2 levels correlate with poor prognosis in colorectal cancer patients and with sensitivity to the kinase inhibitor AT9283 in vitro. Biomolecules, 10, (doi: 10.3390/biom10101365)

Kocher, H. M., Basu, B., Froeling, F. E.M., Sarker, D., Slater, S., Carlin, D., deSouza, N. M., De Paepe, K. N., Goulart, M. R., Hughes, C., Imrali, A., Roberts, R., Pawula, M., Houghton, R., Lawrence, C., Yogeswaran, Y., Mousa, K., Coetzee, C., Sasieni, P., Prendergast, A., Propper, D. J. (2020) Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer. Nature Communications, 11, (doi: 10.1038/s41467-020-18636-w)

Koessinger, A. L., Koessinger, D., Stevenson, K., Cloix, C., Mitchell, L., Nixon, C., Gomez-Roman, N., Chalmers, A. J., Norman, J. C., Tait, S. W.G. (2020) Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts. Scientific Reports, 10, (doi: 10.1038/s41598-020-72322-x)

Moekotte, A. L. et al. (2020) Development and external validation of a prediction model for survival in patients with resected ampullary adenocarcinoma. European Journal of Surgical Oncology, 46, pp. 1717-1726. (doi: 10.1016/j.ejso.2020.04.011)

Carotenuto, P. et al. (2020) Modulation of biliary cancer chemo‐resistance through microRNA‐mediated rewiring of the expansion of CD133+ cells. Hepatology, 72, pp. 982-996. (doi: 10.1002/hep.31094)

Pritchard, J. J.G., Hamilton, G., Hurst, C. D., Fraser, S., Orange, C., Knowles, M. A., Jones, R. J., Leung, H. Y., Iwata, T. (2020) Monitoring of urothelial cancer disease status after treatment by digital droplet PCR liquid biopsy assays. Urologic Oncology: Seminars and Original Investigations, 38, pp. 731.e1-737.e10. (doi: 10.1016/j.urolonc.2020.05.012)

Mitxitorena, I., Somma, D., Mitchell, J. P., Lepistö, M., Tyrchan, C., Smith, E. L., Kiely, P. A., Walden, H., Keeshan, K., Carmody, R. J. (2020) The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits. Journal of Biological Chemistry, 295, pp. 11754-11763. (doi: 10.1074/jbc.RA120.014113)

Ahmed, A. A., Angell, R., Oxenford, S., Worthington, J., Williams, N., Barton, N., Fowler, T. G., O’Flynn, D. E., Sunose, M., McConville, M., Vo, T., Wilson, W. D., Karim, S. A., Morton, J. P., Neidle, S. (2020) Asymmetrically substituted quadruplex-binding naphthalene diimide showing potent activity in pancreatic cancer models. ACS Medicinal Chemistry Letters, 11, pp. 1634-1644. (doi: 10.1021/acsmedchemlett.0c00317)

Roca Portoles, A., Blanco, G., Sumpton, D., Cloix, C., Mullin, M., Mackay, G. M., O'Neill, K., Lemgruber Soares, L., Luo, X., Tait, S. W.G. (2020) Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition. Cell Death and Disease, 11, (doi: 10.1038/s41419-020-02867-2)

Wei, Q., Young, J., Holle, A., Li, J., Bieback, K., Inman, G., Spatz, J. P., Cavalcanti-Adam, E. A. (2020) Soft hydrogels for balancing cell proliferation and differentiation. ACS Biomaterials Science and Engineering, 6, pp. 4687-4701. (doi: 10.1021/acsbiomaterials.0c00854)

Wei, Q., Holle, A., Liu, J., Posa, F., Biagioni, F., Croci, O., Benk, A. S., Young, J., Noureddine, F., Deng, J., Zhang, M., Inman, G. J., Spatz, J. P., Campaner, S., Cavalcanti‐Adam, E. A. (2020) BMP‐2 signaling and mechanotransduction synergize to drive osteogenic differentiation via YAP/TAZ. Advanced Science, 7, (doi: 10.1002/advs.201902931)

Golder, A.M., Steele, C.W., Conn, D., Mackay, G.J., McMillan, D.C., Horgan, P.G., Roxburgh, C.S., McSorley, S.T. (2020) Authors' reply: Effect of preoperative oral antibiotics in combination with mechanical bowel preparation on inflammatory response and short-term outcomes following left-sided colonic and rectal resections. BJS Open, 4, pp. 730-731. (doi: 10.1002/bjs5.50286)

Ferguson, K., Quail, N., Kewin, P., Blyth, K. G. (2020) COVID-19 associated with extensive pulmonary arterial, intracardiac and peripheral arterial thrombosis. BMJ Case Reports, 13, (doi: 10.1136/bcr-2020-237460)

Moekotte, A.L. et al. (2020) Gemcitabine-based adjuvant chemotherapy in subtypes of ampullary adenocarcinoma: international propensity score-matched cohort study. British Journal of Surgery, 107, pp. 1171-1182. (doi: 10.1002/bjs.11555)

Rodrigues, F. S., Miranda, V. S., Carneiro-Lobo, T. C., Scalabrini, L. C., Kruspig, B., Levantini, E., Murphy, D. J., Bassères, D. S. (2020) IKKβ kinase promotes stemness, migration, and invasion in KRAS-driven lung adenocarcinoma cells. International Journal of Molecular Sciences, 21, (doi: 10.3390/ijms21165806)

Sarker, D., Plummer, R., Meyer, T., Sodergren, M. H., Basu, B., Chee, C. E., , (2020) MTL-CEBPA, a small activating RNA therapeutic upregulating C/EBP-α, in patients with advanced liver cancer: a first-in-human, multicenter, open-label, phase I trial. Clinical Cancer Research, 26, pp. 3936-3946. (doi: 10.1158/1078-0432.CCR-20-0414)

Dreyer, S. B. et al. (2020) Precision oncology in surgery: patient selection for operable pancreatic cancer. Annals of Surgery, 272, pp. 366-376. (doi: 10.1097/SLA.0000000000003143)

Millar, R., Kilbey, A., Remak, S.-J., Severson, T. M., Dhayade, S., Sandilands, E., Foster, K., Bryant, D. M., Blyth, K., Coffelt, S. B. (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14, pp. 1868-1880. (doi: 10.1002/1878-0261.12734)

Dhayade, S., Pietzke, M., Wiesheu, R., Tait-Mulder, J., Athineos, D., Sumpton, D., Coffelt, S., Blyth, K., Vazquez, A. (2020) Impact of formate supplementation on body weight and plasma amino acids. Nutrients, 12, (doi: 10.3390/nu12082181)

Horne, G., Stobo, J., Kelly, C., Mukhopadhyay, A., Latif, A.-L., Dixon-Hughes, J., McMahon, L., Cony-Makhoul, P., Byrne, J., Smith, G., Koschmeider, S., Brümmendorf, T.H., Schafhausen, P., Gallipoli, P., Thomson, F., Cong, W., Clark, R. E., Milojkovic, D., Helgason, G. V., Foroni, L., Nicoloni, F. E., Holyoake, T. L., Copland, M. (2020) A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with residual disease. Leukemia, 34, pp. 1775-1786. (doi: 10.1038/s41375-019-0700-9)

AbdulJabbar, K. et al. (2020) Geospatial immune variability illuminates differential evolution of lung adenocarcinoma. Nature Medicine, 26, pp. 1054-1062. (doi: 10.1038/s41591-020-0900-x)

Abdelrasoul, H., Vadakumchery, A., Werner, M., Lenk, L., Khadour, A., Young, M., El Ayoubi, O., Vogiatzi, F., Krämer, M., Schmid, V., Chen, Z., Yousafzai, Y., Cario, G., Schrappe, M., Müschen, M., Halsey, C., Mulaw, M. A., Schewe, D. M., Hobeika, E., Alsadeq, A., Jumaa, H. (2020) Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia. Nature Communications, 11, (doi: 10.1038/s41467-020-16927-w)

McSorley, S. T., Anderson, J. H., Whittle, T., Roxburgh, C. S., Horgan, P. G., McMillan, D. C., Steele, C. W. (2020) The impact of preoperative systemic inflammation on the efficacy of intravenous iron infusion to correct anaemia prior to surgery for colorectal cancer. Perioperative Medicine, 9, (doi: 10.1186/s13741-020-00146-4)

Briggs, A., Daniele, B., Dick, K., Evans, T. R. J., Galle, P. R., Hubner, R. A., Lopez, C., Siebert, U., Tremblay, G. (2020) Covariate-adjusted analysis of the Phase 3 REFLECT study of lenvatinib versus sorafenib in the treatment of unresectable hepatocellular carcinoma. British Journal of Cancer, 122, pp. 1754-1759. (doi: 10.1038/s41416-020-0817-7)

Corrie, P.G. et al. (2020) Scheduling nab-paclitaxel combined with gemcitabine as first line treatment for metastatic pancreatic adenocarcinoma. British Journal of Cancer, 122, pp. 1760-1768. (doi: 10.1038/s41416-020-0846-2)

Kinstrie, R., Horne, G., Morrison, H., Irvine, D., Munje, C., Gómez Castañeda, E., Moka, H. A., Dunn, K., Cassels, J., Parry, N., Clarke, C., Scott, M., Clark, R. E., Holyoake, T. L., Wheadon, H., Copland, M. (2020) CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy. Leukemia, 34, pp. 1613-1625. (doi: 10.1038/s41375-019-0684-5)

Sarrou, E., Richmond, L., Carmody, R. J., Gibson, B., Keeshan, K. (2020) CRISPR gene editing of murine blood stem and progenitor cells induces MLL-AF9 chromosomal translocation and MLL-AF9 leukaemogenesis. International Journal of Molecular Sciences, 21, (doi: 10.3390/ijms21124266)

McNamara, M. G., Goyal, L., Doherty, M., Springfeld, C., Cosgrove, D., Sjoquist, K. M., Park, J. O., Verdaguer, H., Braconi, C., Ross, P., Gramont, A. D., Zalcberg, J. R., Palmer, D. H., Valle, J. W., Knox, J. J. (2020) NUC-1031/cisplatin versus gemcitabine/cisplatin in untreated locally advanced/metastatic biliary tract cancer (NuTide:121) Future Oncology, 16, pp. 1069-1081. (doi: 10.2217/fon-2020-0247)

Rooney, N., Mason, S. M., McDonald, L., Däbritz, J. H. M., Campbell, K. J., Hedley, A., Howard, S., Athineos, D., Nixon, C., Clark, W., Leach, J. D., Sansom, O. J., Edwards, J., Cameron, E. R., Blyth, K. (2020) RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome. Cancer Research, 80, pp. 2325-2339. (doi: 10.1158/0008-5472.CAN-19-3870)

Muthalagu, N., Monteverde, T., Raffo-Iraolagoitia, X., Wiesheu, R., Whyte, D., Hedley, A., Laing, S., Kruspig, B., Upstill-Goddard, R., Shaw, R., Neidler, S., Rink, C., Karim, S. A., Gyuraszova, K., Nixon, C., Clark, W., Biankin, A. V., Carlin, L. M., Coffelt, S. B., Sansom, O. J., Morton, J. P., Murphy, D. J. (2020) Repression of the type I interferon pathway underlies MYC & KRAS-dependent evasion of NK & B cells in pancreatic ductal adenocarcinoma. Cancer Discovery, 10, pp. 872-887. (doi: 10.1158/2159-8290.CD-19-0620)

Conefrey, C., Donovan, J.L., Stein, R.C., Paramasivan, S., Marshall, A., Bartlett, J., Cameron, D., Campbell, A., Dunn, J., Earl, H., Hall, P., Harmer, V., Hughes-Davies, L., Macpherson, I., Makris, A., Morgan, A., Pinder, S., Poole, C., Rea, D., Rooshenas, L. (2020) Strategies to improve recruitment to a de-escalation trial: a mixed-methods study of the OPTIMA prelim trial in early breast cancer. Clinical Oncology, 32, pp. 382-389. (doi: 10.1016/j.clon.2020.01.029)

Blomme, A. et al. (2020) 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer. Nature Communications, 11, (doi: 10.1038/s41467-020-16126-7)

Brunton, H. et al. (2020) HNF4A and GATA6 loss reveals therapeutically actionable subtypes in pancreatic cancer. Cell Reports, 31, (doi: 10.1016/j.celrep.2020.107625)

Scarsbrook, A. F., Bottomley, D., Teoh, E. J., Bradley, K. M., Payne, H., Afaq, A., Bomanji, J., van As, N., Chua, S., Hoskin, P., Chambers, A., Cook, G. J., Warbey, V. S., Han, S., Leung, H. Y., Chau, A., Miller, M. P., Gleeson, F. V., on behalf of the FALCON Study Group, . (2020) Effect of 18F-fluciclovine positron emission tomography on the management of patients with recurrence of prostate cancer: Results from the FALCON Trial. International Journal of Radiation Oncology, Biology, Physics, 107, pp. 316-324. (doi: 10.1016/j.ijrobp.2020.01.050)

Litchfield, K. et al. (2020) Representative sequencing: unbiased sampling of solid tumor tissue. Cell Reports, 31, (doi: 10.1016/j.celrep.2020.107550)

Tzolos, E., Adamson, P.D., Hall, P.S., MacPherson, I.R., Oikonomidou, O., MacLean, M., Lewis, S.C., McVicars, H., Newby, D.E., Mills, N.L., Lang, N.N., Henriksen, P.A. (2020) Dynamic changes in high-sensitivity cardiac troponin I in response to anthracycline-based chemotherapy. Clinical Oncology, 32, pp. 292-297. (doi: 10.1016/j.clon.2019.11.008)

ALHAYYAN, A., McSorley, S. T., Kearns, R. J., Horgan, P. G., Roxburgh, C. S.D., McMillan, D. C. (2020) The relationship between anaesthetic technique, clinicopathological characteristics and the magnitude of the postoperative systemic inflammatory response in patients undergoing elective surgery for colon cancer. PLoS ONE, 15, (doi: 10.1371/journal.pone.0228580)

Riley, J. S., Tait, S. W.G. (2020) Mitochondrial DNA in inflammation and immunity. EMBO Reports, 21, (doi: 10.15252/embr.201949799)

Amato, F., Rae, C., Prete, M. G., Braconi, C. (2020) Cholangiocarcinoma disease modelling through patients derived organoids. Cells, 9, (doi: 10.3390/cells9040832)

Leung, E. Y.L., Ennis, D. P., Kennedy, P. R., Hansell, C., Dowson, S., Farquharson, M., Spiliopoulou, P., Nautiyal, J., McNamara, S., Carlin, L. M., Fisher, K., Davis, D. M., Graham, G., McNeish, I. A. (2020) NK cells augment oncolytic adenovirus cytotoxicity in ovarian cancer. Molecular Therapy - Oncolytics, 16, pp. 289-301. (doi: 10.1016/j.omto.2020.02.001)

Sepp, K., Lee, M., Bluntzer, M., Helgason, G. V., Hulme, A. N., Brunton, V. G. (2020) Utilizing stimulated Raman scattering microscopy to study intracellular distribution of label-free ponatinib in live cells. Journal of Medicinal Chemistry, 63, pp. 2028-2034. (doi: 10.1021/acs.jmedchem.9b01546)

Walker, D. A., Meijer, L., Coyle, B., Halsey, C. (2020) Leptomeningeal malignancy of childhood: sharing learning between childhood leukaemia and brain tumour trials. Lancet Child and Adolescent Health, 4, pp. 242-250. (doi: 10.1016/S2352-4642(19)30333-5)

Neal, D. E. et al. (2020) Ten-year mortality, disease progression, and treatment-related side effects in men with localised prostate cancer from the ProtecT Randomised Controlled Trial according to treatment received. European Urology, 77, pp. 320-330. (doi: 10.1016/j.eururo.2019.10.030)

Michalopoulou, E., Auciello, F. R., Bulusu, V., Strachan, D., Campbell, A. D., Tait-Mulder, J., Karim, S. A., Morton, J. P., Sansom, O. J., Kamphorst, J. J. (2020) Macropinocytosis renders a subset of pancreatic tumor cells resistant to mTOR inhibition. Cell Reports, 30, pp. 2729-2742.e4. (doi: 10.1016/j.celrep.2020.01.080)

Rushworth, L. K., Hewit, K., Munnings-Tomes, S., Somani, S., James, D., Shanks, E., Dufès, C., Straube, A., Patel, R., Leung, H. Y. (2020) Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment. British Journal of Cancer, 122, pp. 517-527. (doi: 10.1038/s41416-019-0681-5)

Patel, R., Brzezinska, E. A., Repiscak, P., Ahmad, I., Mui, E., Gao, M., Blomme, A., Harle, V., Tan, E. H., Malviya, G., Mrowinska, A., Loveridge, C. J., Rushworth, L. K., Edwards, J., Ntala, C., Nixon, C., Hedley, A., Mackay, G., Tardito, S., Sansom, O. J., Leung, H. Y. (2020) Activation of β-catenin cooperates with loss of Pten to drive AR-independent castration-resistant prostate cancer. Cancer Research, 80, pp. 576-590. (doi: 10.1158/0008-5472.CAN-19-1684)

Alsina, A., Kudo, M., Vogel, A., Cheng, A.-L., Tak, W. Y., Ryoo, B.-Y., Evans, T. R. J., López López, C., Daniele, B., Misir, S., Ren, M., Izumi, N., Qin, S., Finn, R. S. (2020) Effects of subsequent systemic anticancer medication following first-line lenvatinib: a post hoc responder analysis from the phase 3 REFLECT study in unresectable hepatocellular carcinoma. Liver Cancer, 9, pp. 93-104. (doi: 10.1159/000504624)

Mohan, S., Foy, V., Ayub, M., Leong, H. S., Schofield, P., Sahoo, S., Descamps, T., Kilerci, B., Smith, N. K., Carter, M., Priest, L., Zhou, C., Carr, T. H., Miller, C., Faivre-Finn, C., Blackhall, F., Rothwell, D. G., Dive, C., Brady, G. (2020) Profiling of circulating free DNA using targeted and genome-wide sequencing in patients with SCLC. Journal of Thoracic Oncology, 15, pp. 216-230. (doi: 10.1016/j.jtho.2019.10.007)

Ferguson, J., Alexander, L., Kelly, C., Chalmers, A., Rahman, N., Holme, J., Grundy, S., Ahmed, L., Maskell, N., Cowell, G., Dick, C., Tsim, S., Hopkins, T., Woodward, R., Blyth, K. (2020) Staging by Thoracoscopy in Potentially Radically Treatable Non-Small Cell Lung Cancer Associated with Minimal Pleural Effusion (STRATIFY) study: a prospective multicentre study. Lung Cancer, 139, (doi: 10.1016/S0169-5002(20)30245-2)

Coleman, R., Brown, J., Rathbone, E., Flanagan, L., Reid, A., Kendall, J., Howell, S., Twelves, C., Palmieri, C., Anand, A., MacPherson, I., Brown, S. (2020) CApecitabine plus Radium-223 (Xofigo™) in breast cancer patients with BONe metastases (CARBON): study protocol for a phase IB/IIA randomised controlled trial. Trials, 21, (doi: 10.1186/s13063-019-3643-6)

Blagih, J., Zani, F., Chakravarty, P., Hennequart, M., Pilley, S., Hobor, S., Hock, A. K., Walton, J. B., Morton, J. P., Gronroos, E., Mason, S., Yang, M., Mcneish, I., Swanton, C., Blyth, K., Vousden, K. (2020) Cancer-specific loss of p53 leads to a modulation of myeloid and T cell responses. Cell Reports, 30, pp. 481-496.e6. (doi: 10.1016/j.celrep.2019.12.028)

Dreyer, S.B., Jamieson, N.B., Cooke, S.L., Valle, J.W., McKay, C.J., Biankin, A.V., Chang, D.K. (2020) PRECISION-Panc: the next generation therapeutic development platform for pancreatic cancer. Clinical Oncology, 32, pp. 1-4. (doi: 10.1016/j.clon.2019.07.011)

Dreyer, S.B., Jamieson, N.B., Morton, J.P., Sansom, O.J., Biankin, A.V., Chang, D.K. (2020) Pancreatic cancer: from genome discovery to PRECISION-Panc. Clinical Oncology, 32, pp. 5-8. (doi: 10.1016/j.clon.2019.08.007)

Cebon, J. S. et al. (2020) Results of a randomized, double-blind phase II clinical trial of NY-ESO-1 vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in participants with high-risk resected melanoma. Journal for ImmunoTherapy of Cancer, 8, (doi: 10.1136/jitc-2019-000410)

Forster, V. J., Bell, G., Halsey, C. (2020) Should nitrous oxide ever be used in oncology patients receiving methotrexate therapy? Pediatric Anesthesia, 30, pp. 9-16. (doi: 10.1111/pan.13760)

Alhayyan, A., McSorley, S., Roxburgh, C., Kearns, R., Horgan, P., McMillan, D. (2020) The effect of anesthesia on the postoperative systemic inflammatory response in patients undergoing surgery: a systematic review and meta-analysis. Surgery Open Science, 2, pp. 1-21. (doi: 10.1016/j.sopen.2019.06.001)

Loveridge, C. J., Slater, S., Campbell, K. J., Nam, N. A., Knight, J., Ahmad, I., Hedley, A., Lilla, S., Repiscak, P., Patel, R., Salji, M., Fleming, J., Mitchell, L., Nixon, C., Strathdee, D., Neilson, M., Ntala, C., Bryson, S., Zanivan, S. R., Edwards, J., Robson, C. N., Goodyear, C. S., Blyth, K., Leung, H. Y. (2020) BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration. Oncogene, 39, pp. 1797-1806. (doi: 10.1038/s41388-019-1106-x)

Bock, F. J., Tait, S. W.G. (2020) Mitochondria as multifaceted regulators of cell death. Nature Reviews Molecular Cell Biology, 21, pp. 85-100. (doi: 10.1038/s41580-019-0173-8)

McSorley, S. T., Tham, A., Dolan, R. D., Steele, C. W., Ramsingh, J., Roxburgh, C., Horgan, P. G., McMillan, D. C. (2020) Perioperative blood transfusion is associated with the postoperative systemic inflammatory response and poorer outcomes following surgery for colorectal cancer. Annals of Surgical Oncology, 27, pp. 833-843. (doi: 10.1245/s10434-019-07984-7)

Vetrie, D., Helgason, V., Copland, M. (2020) The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML. Nature Reviews Cancer, 20, pp. 158-173. (doi: 10.1038/s41568-019-0230-9)

MacPherson, I. R., Spiliopoulou, P., Rafii, S., Saggese, M., Baird, R. D., Garcia-Corbacho, J., Italiano, A., Bonneterre, J., Campone, M., Cresti, N., Posner, J., Takeda, Y., Arimura, A., Spicer, J. (2019) A phase I/II study of epertinib plus trastuzumab with or without chemotherapy in patients with HER2-positive metastatic breast cancer. Breast Cancer Research, 22, (doi: 10.1186/s13058-019-1178-0)

Collins, P. E., Somma, D., Kerrigan, D., Herrington, F., Keeshan, K. R., Nibbs, R. J.B., Carmody, R. J. (2019) The IκB-protein BCL-3 controls toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus. Proceedings of the National Academy of Sciences of the United States of America, 116, pp. 25828-25838. (doi: 10.1073/pnas.1900408116)

Golder, A. M., McSorley, S. T., Kearns, R. J., McMillan, D. C., Horgan, P. G., Roxburgh, C. S. (2019) Attitudes towards the use of perioperative steroids in resectional colorectal cancer surgery in the UK: a qualitative study. Annals of Medicine and Surgery, 48, pp. 23-28. (doi: 10.1016/j.amsu.2019.10.007)

Liko, D., Mitchell, L., Campbell, K., Ridgway, R., Jones, C., Dudek, K., King, A., Bryson, S., Stevenson, D., Blyth, K., Strathdee, D., Morton, J. P., Bird, T., Knight, J. R.P., Willis, A. E., Sansom, O. J. (2019) Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. Cell Death and Differentiation, 26, pp. 2535-2550. (doi: 10.1038/s41418-019-0316-7)

Golder, A.M., Steele, C.W., Conn, D., Mackay, G.J., McMillan, D.C., Horgan, P.G., Roxburgh, C.S., McSorley, S.T. (2019) Effect of preoperative oral antibiotics in combination with mechanical bowel preparation on inflammatory response and short‐term outcomes following left‐sided colonic and rectal resections. BJS Open, 3, pp. 830-839. (doi: 10.1002/bjs5.50224)

Smith, E. L., Somma, D., Kerrigan, D., McIntyre, Z., Cole, J. J., Liang, K. L., Kiely, P. A., Keeshan, K., Carmody, R. J. (2019) The regulation of sequence specific NF-ĸB DNA binding and transcription by IKKβ Phosphorylation of NF-ĸB p50 at Serine 80. Nucleic Acids Research, 47, pp. 11151-11161. (doi: 10.1093/nar/gkz873)

Almasaudi, A. S., McSorley, S. T., Dolan, R. D., Edwards, C. A., McMillan, D. C. (2019) The relation between Malnutrition Universal Screening Tool (MUST), computed tomography-derived body composition, systemic inflammation, and clinical outcomes in patients undergoing surgery for colorectal cancer. American Journal of Clinical Nutrition, 110, pp. 1327-1334. (doi: 10.1093/ajcn/nqz230)

Yousafzai, Y. M., Smith, L., Smith, A., Bhatti, S., Gardiner, M., Cousins, A., Fee, F., Chudleigh, S., Spence, A., Taylor, W., Heaney, N., Gibson, B., Graham, G., Halsey, C. (2019) Use of quantitative polymerase chain reaction (qPCR) for the diagnosis and monitoring of CNS leukaemia. Leukemia Research, 87, (doi: 10.1016/j.leukres.2019.106232)

Claudiani, S., Metelli, S., Kamvar, R., Szydlo, R., Khan, A., Byrne, J., Gallipoli, P., Bulley, S. J., Horne, G. A., Rothwell, K., Copland, M., Clark, R. E., Khorashad, J. S., Foroni, L., Milojkovic, D., Apperley, J. F. (2019) Introducing a predictive score for successful treatment free remission in chronic myeloid leukemia (CML) Blood, 134, pp. 26. (doi: 10.1182/blood-2019-131500)

Naumann, R. W., Hollebecque, A., Meyer, T., Devlin, M.-J., Oaknin, A., Kerger, J., López-Picazo, J. M., Machiels, J.-P., Delord, J.-P., Evans, T. R.J., Boni, V., Calvo, E., Topalian, S. L., Chen, T., Soumaoro, I., Li, B., Gu, J., Zwirtes, R., Moore, K. N. (2019) Safety and efficacy of nivolumab monotherapy in recurrent or metastatic cervical, vaginal, or vulvar carcinoma: Results from the phase I/II CheckMate 358 trial. Journal of Clinical Oncology, 37, pp. 2825-2834. (doi: 10.1200/JCO.19.00739)

Joharatnam-Hogan, N. et al. (2019) Aspirin as an adjuvant treatment for cancer: feasibility results from the Add-Aspirin randomised trial. Lancet Gastroenterology and Hepatology, 4, pp. 854-862. (doi: 10.1016/S2468-1253(19)30289-4)

Pereira, B. A., Vennin, C., Papanicolaou, M., Chambers, C. R., Herrmann, D., Morton, J. P., Cox, T. R., Timpson, P. (2019) CAF subpopulations: a new reservoir of stromal targets in pancreatic cancer. Trends in Cancer, 5, pp. 724-741. (doi: 10.1016/j.trecan.2019.09.010)

Almasaudi, A. S., Dolan, R. D., McSorley, S. T., Horgan, P. G., Edwards, C., McMillan, D. C. (2019) Relationship between computed tomography-derived body composition, sex, and post-operative complications in patients with colorectal cancer. European Journal of Clinical Nutrition, 73, pp. 1450-1457. (doi: 10.1038/s41430-019-0414-0)

Bott, A. J. et al. (2019) Glutamine anabolism plays a critical role in pancreatic cancer by coupling carbon and nitrogen metabolism. Cell Reports, 29, pp. 1287-1298.e6. (doi: 10.1016/j.celrep.2019.09.056)

Mussai, F., Wheat, R., Sarrou, E., Booth, S., Stavrou, V., Fultang, L., Perry, T., Kearns, P., Cheng, P., Keeshan, K., Craddock, C., De Santo, C. (2019) Targeting the arginine metabolic brake enhances immunotherapy for leukaemia. International Journal of Cancer, 145, pp. 2201-2208. (doi: 10.1002/ijc.32028)

Birrell, F., Leung, H. Y. (2019) The Scottish prostate cryotherapy service-the role of the clinical nurse specialist. British Journal of Nursing, 28, pp. S12-S16. (doi: 10.12968/bjon.2019.28.18.S12)

Jones, R. L. et al. (2019) Phase II randomised discontinuation trial of brivanib in patients with advanced solid tumours. European Journal of Cancer, 120, pp. 132-139. (doi: 10.1016/j.ejca.2019.07.024)

Chemi, F. et al. (2019) Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse. Nature Medicine, 25, pp. 1534-1539. (doi: 10.1038/s41591-019-0593-1)

Jackstadt, R. et al. (2019) Epithelial NOTCH signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis. Cancer Cell, 36, pp. 319-336.e7. (doi: 10.1016/j.ccell.2019.08.003)

Park, J. H., van Wyk, H., McMillan, D. C., Edwards, J., Orange, C., Horgan, P. G., Roxburgh, C. S.D. (2019) Pre-operative, biopsy-based assessment of the tumour microenvironment in patients with primary operable colorectal cancer. Journal of Pathology: Clinical Research, 6, pp. 30-39. (doi: 10.1002/cjp2.143)

McSorley, S. T., Dolan, R. D., Roxburgh, C. S.D., Horgan, P. G., MacKay, G. J., McMillan, D. C. (2019) Possible dose dependent effect of perioperative dexamethasone and laparoscopic surgery on the postoperative systemic inflammatory response and complications following surgery for colon cancer. European Journal of Surgical Oncology, 45, pp. 1613-1618. (doi: 10.1016/j.ejso.2019.05.020)

Matheson, E. C., Thomas, H., Case, M., Blair, H., Jackson, R. K., Masic, D., Veal, G., Halsey, C., Newell, D. R., Vormoor, J., Irving, J. A.E. (2019) Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM. Haematologica, 104, pp. 1804-1811. (doi: 10.3324/haematol.2017.185975)

Wellenstein, M. D., Coffelt, S. B., Duits, D. E.M., van Miltenburg, M. H., Slagter, M., de Rink, I., Henneman, L., Kas, S. M., Prekovic, S., Hau, C.-S., Vrijland, K., Drenth, A. P., de Korte-Grimmerink, R., Schut, E., van der Heijden, I., Zwart, W., Wessels, L. F.A., Schumacher, T. N.M., Jonkers, J., de Visser, K. E. (2019) Loss of p53 triggers Wnt-dependent systemic inflammation to drive breast cancer metastasis. Nature, 572, pp. 538-542. (doi: 10.1038/s41586-019-1450-6)

Mackey, J. B.G., Coffelt, S. B., Carlin, L. M. (2019) Neutrophil maturity in cancer. Frontiers in Immunology, 10, (doi: 10.3389/fimmu.2019.01912)

Vennin, C. et al. (2019) CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan. Nature Communications, 10, (doi: 10.1038/s41467-019-10968-6)

Brunton, H. et al. (2019) HNF4A and GATA6 loss reveals therapeutically actionable subtypes in pancreatic cancer. Cell Press Sneak Peek, (doi: 10.2139/ssrn.3430714)

Copland, M. (2019) Is there a role for dose modification of TKI therapy in CML. Current Hematologic Malignancy Reports, 14, pp. 337-345. (doi: 10.1007/s11899-019-00524-w)

Salati, M., Valeri, N., Spallanzani, A., Braconi, C., Cascinu, S. (2019) Oligometastatic gastric cancer: an emerging clinical entity with distinct therapeutic implications. European Journal of Surgical Oncology, 45, pp. 1479-1482. (doi: 10.1016/j.ejso.2018.11.006)

Orozco, S. L., Daniels, B. P., Yatim, N., Messmer, M. N., Quarato, G., Chen-Harris, H., Cullen, S. P., Snyder, A. G., Ralli-Jain, P., Frase, S., Tait, S. W.G., Green, D. R., Albert, M. L., Oberst, A. (2019) RIPK3 activation leads to cytokine synthesis that continues after loss of cell membrane integrity. Cell Reports, 28, pp. 2275-2287.e5. (doi: 10.1016/j.celrep.2019.07.077)

Salati, M., Caputo, F., Cunningham, D., Marcheselli, L., Spallanzani, A., Rimini, M., Gelsomino, F., Reggiani-Bonetti, L., Andrikou, K., Rovinelli, F., Smyth, E., Baratelli, C., Kouvelakis, K., Kalaitzaki, R., Gillbanks, A., Michalarea, V., Cascinu, S., Braconi, C. (2019) The A.L.A.N. score identifies prognostic classes in advanced biliary cancer patients receiving first-line chemotherapy. European Journal of Cancer, 117, pp. 84-90. (doi: 10.1016/j.ejca.2019.05.030)

Andisha, N. M., McMillan, D. C., Gujam, F. J.A., Roseweir, A., Edwards, J. (2019) The relationship between phosphorylation status of focal adhesion kinases, molecular subtypes, tumour microenvironment and survival in patients with primary operable ductal breast cancer. Cellular Signalling, 60, pp. 91-99. (doi: 10.1016/j.cellsig.2019.04.006)

Banerji, U., van Herpen, C. M.L., Saura, C., Thistlethwaite, F., Lord, S., Moreno, V., Macpherson, I. R., Boni, V., Rolfo, C., de Vries, E. G.E., Rottey, S., Greenen, J., Eskens, F., Gil-Martin, M., Mommers, E. C., Koper, N. P., Aftimos, P. (2019) Trastuzumab duocarmazine in locally advanced and metastatic solid tumours and HER2-expressing breast cancer: a phase 1 dose-escalation and dose-expansion study. Lancet Oncology, 20, pp. 1124-1135. (doi: 10.1016/S1470-2045(19)30328-6)

Evans, T. R. J., Kudo, M., Finn, R. S., Han, K.-H., Cheng, A.-L., Ikeda, M., Kraljevic, S., Ren, M., Ductus, C. E., Piscaglia, F., Sung, M. W. (2019) Urine protein:creatinine ratio vs 24-hour urine protein for proteinuria management: analysis from the phase 3 REFLECT study of lenvatinib vs sorafenib in hepatocellular carcinoma. British Journal of Cancer, 121, pp. 218-221. (doi: 10.1038/s41416-019-0506-6)

Reader, C. S., Vallath, S., Steele, C. W., Haider, S., Brentnall, A., Desai, A., Moore, K. M., Jamieson, N. B., Chang, D., Bailey, P., Scarpa, A., Lawlor, R., Chelala, C., Keyse, S. M., Biankin, A., Morton, J. P., Evans, T.R. J., Barry, S. T., Sansom, O. J., Kocher, H. M., Marshall, J. F. (2019) The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy. Journal of Pathology, 249, pp. 332-342. (doi: 10.1002/path.5320)

Tsim, S., Paterson, S., Cartwright, D., Fong, C. J., Alexander, L., Kelly, C., Holme, J., Evison, M., Blyth, K. G. (2019) Baseline predictors of negative and incomplete pleural cytology in patients with suspected pleural malignancy - Data supporting 'Direct to LAT' in selected groups. Lung Cancer, 133, pp. 123-129. (doi: 10.1016/j.lungcan.2019.05.017)

Clark, R. E., Polydoros, F., Apperley, J. F., Milojkovic, D., Rothwell, K., Pocock, C., Byrne, J., de Lavallade, H., Osborne, W., Robinson, L., O’Brien, S. G., Read, L., Foroni, L., Copland, M. (2019) De-escalation of tyrosine kinase inhibitor therapy before complete treatment discontinuation in patients with chronic myeloid leukaemia (DESTINY): a non-randomised, phase 2 trial. Lancet Haematology, 6, pp. e375-e383. (doi: 10.1016/S2352-3026(19)30094-8)

Johnson, S. A., Ormsby, M. J., McIntosh, A., Tait, S. W.G., Blyth, K., Wall, D. M. (2019) Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori. Cancer Gene Therapy, 26, pp. 183-194. (doi: 10.1038/s41417-018-0039-9)

McSorley, S. T., Tham, A., Steele, C. W., Dolan, R. D., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. C. (2019) Quantitative data on red cell measures of iron status and their relation to the magnitude of the systemic inflammatory response and survival in patients with colorectal cancer. European Journal of Surgical Oncology, 45, pp. 1205-1211. (doi: 10.1016/j.ejso.2019.02.027)

Anandappa, G. et al. (2019) miR-31-3p expression and benefit from anti-EGFR inhibitors in metastatic colorectal cancer patients enrolled in the prospective phase II PROSPECT-C trial. Clinical Cancer Research, 25, pp. 3830-3838. (doi: 10.1158/1078-0432.ccr-18-3769)

Silva-Santos, B., Mensurado, S., Coffelt, S. B. (2019) γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer. Nature Reviews Cancer, 19, pp. 392-404. (doi: 10.1038/s41568-019-0153-5)

Vringer, E., Tait, S. W.G. (2019) Mitochondria and inflammation: cell death heats up. Frontiers in Cell and Developmental Biology, 7, (doi: 10.3389/fcell.2019.00100)

Hari, P., Millar, F. R., Tarrats, N., Birch, J., Quintanilla, A., Rink, C. J., Fernández-Duran, I., Muir, M., Finch, A. J., Brunton, V. G., Passos, J. F., Morton, J. P., Boulter, L., Acosta, J. C. (2019) The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Science Advances, 5, (doi: 10.1126/sciadv.aaw0254)

Halbrook, C. J., Pontious, C., Kovalenko, I., Lapienyte, L., Dreyer, S., Lee, H.-J., Thurston, G., Zhang, Y., Lazarus, J., Sajjakulnukit, P., Hong, H. S., Kremer, D. M., Nelson, B. S., Kemp, S., Zhang, L., Chang, D., Biankin, A., Shi, J., Frankel, T. L., Crawford, H. C., Morton, J. P., Pasca di Magliano, M., Lyssiotis, C. A. (2019) Macrophage-released pyrimidines inhibit gemcitabine therapy in pancreatic cancer. Cell Metabolism, 29, pp. 1390-1399.e6. (doi: 10.1016/j.cmet.2019.02.001)

Leach, J., Morton, J. P., Sansom, O. J. (2019) Neutrophils: homing in on the myeloid mechanisms of metastasis. Molecular Immunology, 110, pp. 69-76. (doi: 10.1016/j.molimm.2017.12.013)

Khongthong, P., Roseweir, A. K., Edwards, J. (2019) The NF-KB pathway and endocrine therapy resistance in breast cancer. Endocrine-Related Cancer, 26, pp. R369-R380. (doi: 10.1530/ERC-19-0087)

Palmieri, C., Macpherson, I. (2019) Use of the Child-Pugh score in anticancer drug dosing decision making: proceed with caution. Lancet Oncology, 20, pp. e289. (doi: 10.1016/S1470-2045(19)30296-7)

Memon, D., Bi, J., Miller, C. J. (2019) In silico prediction of housekeeping long intergenic non-coding RNAs reveals HKlincR1 as an essential player in lung cancer cell survival. Scientific Reports, 9, (doi: 10.1038/s41598-019-43758-7)

Roseweir, A. K., Clark, J., McSorley, S. T., vanWyk, H. C., Quinn, J. A., Horgan, P. G., McMillan, D. C., Park, J. H., Edwards, J. (2019) The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer. International Journal of Cancer, 144, pp. 2320-2329. (doi: 10.1002/ijc.32045)

Auciello, F. R., Bulusu, V., Oon, C., Tait-Mulder, J., Berry, M., Bhattacharyya, S., Tumanov, S., Allen-Petersen, B. L., Link, J., Kendsersky, N. D., Vringer, E., Schug, M., Novo, D., Hwang, R. F., Evans, R. M., Nixon, C., Dorrell, C., Morton, J. P., Norman, J. C., Sears, R. C., Kamphorst, J. J., Sherman, M. H. (2019) A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression. Cancer Discovery, 9, pp. 617-627. (doi: 10.1158/2159-8290.CD-18-1212)

Banales, J. M., Cardinale, V., Macias, R., Andersen, J. B., Braconi, C., Carpino, G., Alvaro, D., Calvisi, D. F. (2019) Cholangiocarcinoma: state‐of‐the‐art knowledge and challenges. Liver International, 39, pp. 5-6. (doi: 10.1111/liv.14101)

Badshah, I.I., Brown, S., Weibel, L., Rose, A., Way, B., Sebire, N., Inman, G., Harper, J., O'Shaughnessy, R.F.L. (2019) Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts. British Journal of Dermatology, 180, pp. 1135-1149. (doi: 10.1111/bjd.17352)

Braconi, C., Roessler, S., Kruk, B., Lammert, F., Krawczyk, M., Andersen, J. B. (2019) Molecular perturbations in cholangiocarcinoma: is it time for precision medicine? Liver International, 39, pp. 32-42. (doi: 10.1111/liv.14085)

McSorley, S. T., Tham, A., Jones, I., Talwar, D., McMillan, D. C. (2019) Regression correction equation to adjust serum iron and ferritin concentrations based on C-reactive protein and albumin in patients receiving primary and secondary care. Journal of Nutrition, 149, pp. 877-883. (doi: 10.1093/jn/nxz008)

Rothwell, D. G. et al. (2019) Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study. Nature Medicine, 25, pp. 738-743. (doi: 10.1038/s41591-019-0380-z)

Neidler, S., Kruspig, B., Hewit, K., Monteverde, T., Gyuraszova, K., Braun, A., Clark, W., James, D., Hedley, B., Nieswandt, B., Shanks, E., Dick, C., Murphy, D. J. (2019) Identification of a clinically relevant signature for early progression in KRAS-driven lung adenocarcinoma. Cancers, 11, (doi: 10.3390/cancers11050600)

Salvucci, M., Rahman, A., Resler, A. J., Udupi, G. M., McNamara, D. A., Kay, E. W., Laurent-Puig, P., Longley, D. B., Johnston, P. G., Lawler, M., Wilson, R., Salto-Tellez, M., Van Schaeybroeck, S., Rafferty, M., Gallagher, W. M., Rehm, M., Prehn, J. H.M. (2019) A machine learning platform to optimize the translation of personalized network models to the clinic. JCO Clinical Cancer Informatics, pp. 1-17. (doi: 10.1200/CCI.18.00056)

Neves, K. B., Rios, F. J., Jones, R., Evans, T. R. J., Montezano, A. C., Touyz, R. M. (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115, pp. 978-988. (doi: 10.1093/cvr/cvz021)

Dolan, R. D., McLees, N. G., Irfan, A., McSorley, S. T., Horgan, P. G., Colville, D., McMillan, D. C. (2019) The relationship between tumour glucose metabolism and host systemic inflammatory responses in patients with cancer: a systematic review. Journal of Nuclear Medicine, 60, pp. 467-471. (doi: 10.2967/jnumed.118.216697)

McAllister, M. J., Underwood, M. A., Leung, H. Y., Edwards, J. (2019) A review on the interactions between the tumour microenvironment and androgen receptor signaling in prostate cancer. Translational Research, 206, pp. 91-106. (doi: 10.1016/j.trsl.2018.11.004)

Baquero, P., Dawson, A., Helgason, G. V. (2019) Autophagy and mitochondrial metabolism: insights into the role and therapeutic potential in chronic myeloid leukaemia. FEBS Journal, 286, pp. 1271-1283. (doi: 10.1111/febs.14659)

Conway, J. R.W., Herrmann, D., Evans, T.R. J., Morton, J. P., Timpson, P. (2019) Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine. Gut, 68, pp. 742-758. (doi: 10.1136/gutjnl-2018-316822)

Dreyer, S. B., Jamieson, N. B., Evers, L., Duthie, F., Cooke, S., Marshall, J., Beraldi, D., Knight, S., Upstill-Goddard, R., Dickson, E. J., Carter, C. R., McKay, C. J., Biankin, A. V., Chang, D. K. (2019) Feasibility and clinical utility of endoscopic ultrasound guided biopsy of pancreatic cancer for next-generation molecular profiling. Chinese Clinical Oncology, 8, (doi: 10.21037/cco.2019.04.06)

Cunningham, Y., Wyke, S., Blyth, K. G., Rigg, D., Macdonald, S., Macleod, U., Harrow, S., Robb, K. A., Whitaker, K. L. (2019) Lung cancer symptom appraisal among people with chronic obstructive pulmonary disease: a qualitative interview study. Psycho-Oncology, 28, pp. 718-725. (doi: 10.1002/pon.5005)

Roseweir, A. K., Powell, A. G.M.T., Horstman, S. L., Inthagard, J., Park, J. A., McMillan, D. C., Horgan, P. G., Edwards, J. (2019) Src family kinases, HCK and FGR, associate with local inflammation and tumour progression in colorectal cancer. Cellular Signalling, 56, pp. 15-22. (doi: 10.1016/j.cellsig.2019.01.007)

Baquero, P., Dawson, A., Mukhopadhyay, A., Kuntz, E. M., Mitchell, R., Olivares, O., Ianniciello, A., Scott, M. T., Dunn, K., Nicastri, M. C., Winkler, J. D., Michie, A. M., Ryan, K. M., Halsey, C., Gottlieb, E., Keaney, E. P., Murphy, L. O., Amaravadi, R. K., Holyoake, T. L., Helgason, G. V. (2019) Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia, 33, pp. 981-994. (doi: 10.1038/s41375-018-0252-4)

Almasaudi, A. S., McSorley, S. T., Horgan, P. G., McMillan, D. C., Edwards, C. A. (2019) The relationship between body mass index, sex, and postoperative outcomes in patients undergoing potentially curative surgery for colorectal cancer. Clinical Nutrition ESPEN, 30, pp. 185-189. (doi: 10.1016/j.clnesp.2018.12.084)

Salvagno, C., Ciampricotti, M., Tuit, S., Hau, C.-S., van Weverwijk, A., Coffelt, S. B., Kersten, K., Vrijland, K., Kos, K., Ulas, T., Song, J.-Y., Ooi, C.-H., Rüttinger, D., Cassier, P. A., Jonkers, J., Schultze, J. L., Ries, C. H., de Visser, K. E. (2019) Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response. Nature Cell Biology, 21, pp. 511-521. (doi: 10.1038/s41556-019-0298-1)

Twelves, C., Anthoney, A., Savulsky, C. I., Guo, M., Reyderman, L., Cresti, N., Semiglazov, V., Timcheva, C., Zubairi, I., Morrison, R., Plummer, R., Evans, T.R. J. (2019) A phase 1b/2, open-label, dose-escalation, and dose-confirmation study of eribulin mesilate in combination with capecitabine. British Journal of Cancer, 120, pp. 579-586. (doi: 10.1038/s41416-018-0366-5)

Anderson, R. L., Balasas, T., Callaghan, J., Coombes, R. C., Evans, J., Hall, J. A., Kinrade, S., Jones, D., Jones, P. S., Jones, R., Marshall, J. F., Panico, M. B., Shaw, J. A., Steeg, P. S., Sullivan, M., Tong, W., Westwell, A. D., Ritchie, J. W.A. (2019) A framework for the development of effective anti-metastatic agents. Nature Reviews Clinical Oncology, 16, pp. 185-204. (doi: 10.1038/s41571-018-0134-8)

Khan, K., Rane, J. K., Cunningham, D., Rao, S., Watkins, D., Starling, N., Kalaitzaki, E., Forster, M., Braconi, C., Valeri, N., Gerlinger, M., Chau, I. (2019) Efficacy and cardiotoxic safety profile of raltitrexed in fluoropyrimidines-pretreated or high-risk cardiac patients with GI malignancies: large single-center experience. Clinical Colorectal Cancer, 18, pp. 64-71.e1. (doi: 10.1016/j.clcc.2018.09.010)

McSorley, S., Johnstone, M., Steele, C. W., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. C., Mansouri, D. (2019) Normocytic anaemia is associated with systemic inflammation and poorer survival in patients with colorectal cancer treated with curative intent. International Journal of Colorectal Disease, 34, pp. 401-408. (doi: 10.1007/s00384-018-3211-7)

Kdadra, M., Höckner, S., Leung, H., Kremer, W., Schiffer, E. (2019) Metabolomics biomarkers of prostate cancer: A systematic review. Diagnostics, 9, (doi: 10.3390/diagnostics9010021)

Scopelliti, A., Bauer, C., Yu, Y., Zhang, T., Kruspig, B., Murphy, D. J., Vidal, M., Maddocks, O. D.K., Cordero, J. B. (2019) A neuronal relay mediates a nutrient responsive gut/fat body axis regulating energy homeostasis in adult Drosophila. Cell Metabolism, 29, pp. 269-284.e10. (doi: 10.1016/j.cmet.2018.09.021)

Parry, M. A., Srivastava, S., Ali, A., Cannistraci, A., Antonello, J., Barros-Silva, J. D., Ubertini, V., Ramani, V., Lau, M., Shanks, J., Nonaka, D., Oliveira, P., Hambrock, T., Leong, H. S., Dhomen, N., Miller, C., Brady, G., Dive, C., Clarke, N. W., Marais, R., Baena, E. (2019) Genomic evaluation of multiparametric magnetic resonance imaging-visible and -nonvisible lesions in clinically localised prostate cancer. European Urology Oncology, 2, pp. 1-11. (doi: 10.1016/j.euo.2018.08.005)

Salati, M., Braconi, C. (2019) Noncoding RNA in cholangiocarcinoma. Seminars in Liver Disease, 39, pp. 13-25. (doi: 10.1055/s-0038-1676097)

Spender, L. C., Ferguson, G. J., Hughes, G. D., Davies, B. R., Goldberg, F. W., Herrera, B., Taylor, R. G., Strathearn, L. S., Sansom, O. J., Barry, S. T., Inman, G. I. (2019) Preclinical evaluation of AZ12601011 and AZ12799734, inhibitors of transforming growth factor β superfamily type 1 receptors. Molecular Pharmacology, 95, pp. 222-234. (doi: 10.1124/mol.118.112946)

Pennel, K. A.F., Park, J. H., McMillan, D. C., Roseweir, A. K., Edwards, J. (2019) Signal interaction between the tumour and inflammatory cells in patients with gastrointestinal cancer: implications for treatment. Cellular Signalling, 54, pp. 81-90. (doi: 10.1016/j.cellsig.2018.11.013)

Dolan, R., Almasaudi, A. S., Dieu, L. B., Horgan, P. G., McSorley, S. T., McMillan, D. C. (2019) The relationship between computed tomography‐derived body composition, systemic inflammatory response, and survival in patients undergoing surgery for colorectal cancer. Journal of Cachexia, Sarcopenia and Muscle, 10, pp. 111-122. (doi: 10.1002/jcsm.12357)

Fassan, M., Cui, R., Gasparini, P., Mescoli, C., Guzzardo, V., Vicentini, C., Munari, G., Loupakis, F., Lonardi, S., Braconi, C., Scarpa, M., D'Angelo, E., Pucciarelli, S., Angriman, I., Agostini, M., D'Incá, R., Farinati, F., Gafà, R., Lanza, G., Frankel, W. L., Croce, C. M., Valeri, N., Rugge, M. (2019) miR-224 is significantly upregulated and targets caspase-3 and caspase-7 during colorectal carcinogenesis. Translational Oncology, 12, pp. 282-291. (doi: 10.1016/j.tranon.2018.10.013)

Evans, T.R. J., Dean, E., Molife, L. R., Lopez, J., Ranson, M., El-Khouly, F., Zubairi, I., Savulsky, C., Reyderman, L., Jia, Y., Sweeting, L., Greystroke, A., Barriuso, J., Kristeleit, R. (2019) Phase 1 dose-finding and pharmacokinetic study of eribulin-liposomal formulation in patients with solid tumours. British Journal of Cancer, (doi: 10.1038/s41416-019-0377-x)

Lallo, A., Gulati, S., Schenk, M. W., Khandelwal, G., Berglund, U. W., Pateras, I. S., Chester, C. P. E., Pham, T. M., Kalderen, C., Frese, K. K., Gorgoulis, V. G., Miller, C., Blackhall, F., Helleday, T., Dive, C. (2019) Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics. British Journal of Pharmacology, 176, pp. 436-450. (doi: 10.1111/bph.14542)

Roseweir, A.K., Kong, C.Y., Park, J.H., Bennett, L., Powell, A.G.M.T., Quinn, J., van Wyk, H.C., Horgan, P.G., McMillan, D.C., Edwards, J., Roxburgh, C.S. (2019) A novel tumor-based epithelial-to-mesenchymal transition score that associates with prognosis and metastasis in patients with stage II/III colorectal cancer. International Journal of Cancer, 144, pp. 150-159. (doi: 10.1002/ijc.31739)

Allen-Petersen, B. L., Risom, T., Feng, Z., Wang, Z., Jenny, Z. P., Thoma, M. C., Pelz, K. R., Morton, J. P., Sansom, O. J., Lopez, C. D., Sheppard, B., Christensen, D. J., Ohlmeyer, M., Narla, G., Sears, R. C. (2019) Activation of PP2A and Inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma. Cancer Research, 79, pp. 209-219. (doi: 10.1158/0008-5472.CAN-18-0717)

Mitchell, R., Copland, M. (2019) Defining niche interactions to target chronic myeloid leukemia stem cells. Haematologica, 105, pp. 2-4. (doi: 10.3324/haematol.2019.234898)

Inthagard, J., Edwards, J., Roseweir, A. K. (2019) Immunotherapy: enhancement the efficacy of this promising therapeutic in multiple cancers. Clinical Science, 133, pp. 181-193. (doi: 10.1042/CS20181003)

Morrow, E., Roseweir, A., Edwards, J. (2019) The role of gamma delta T lymphocytes in breast cancer: a review. Translational Research, 203, pp. 88-96. (doi: 10.1016/j.trsl.2018.08.005)

Hassan, S., Purdie, K. J., Wang, J., Harwood, C. A., Proby, C. M., Pourreyron, C., Mladkova, N., Nagano, A., Dhayade, S., Athineos, D., Caley, M., Mannella, V., Blyth, K., Inman, G. J., Leigh, I. M. (2019) A unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing. International Journal of Molecular Sciences, 20, (doi: 10.3390/ijms20143428)

Lopez, J., Tait, S. W.G. (2019) Application of mito-priming to generate BCL-2 addicted cells. Humana Press

Smith, L. D., Minton, A. R., Blunt, M. D., Karydis, L. I., Dutton, D. A., Rogers-Broadway, K.-R., Dobson, R., Liu, R., Norster, F., Hogg, E., Ashton-Key, M., Strefford, J. C., Jia, L., Efremov, D. G., Helgason, G. V., Johnson, P. W.M., Stevenson, F. K., Forconi, F., Cragg, M. S., Tumbarello, D. A., Packham, G., Steele, A. J. (2019) BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia. Leukemia, 34, pp. 640-644. (doi: 10.1038/s41375-019-0557-y)

Beaumatin, F., O'Prey, J., Barthet, V. J.A., Zunino, B., Parvy, J.-P., Bachmann, A. M., O'Prey, M., Kania, E., Gonzalez, P. S., Macintosh, R., Lao, L. Y., Nixon, C., Lopez, J., Long, J. S., Tait, S. W.G., Ryan, K. N. (2019) DRAM-1 is required for mTORC1 activation by facilitating lysosomal amino acid efflux. Molecular Cell, 76, pp. 163-176.E8. (doi: 10.1016/j.molcel.2019.07.021)

Van Wyk, H., Roseweir, A., Alexander, P., Park, J. H., Horgan, P., McMillan, D., Edwards, J. (2019) The relationship between tumour budding, tumour microenvironment and survival in patients with primary operable colorectal cancer. Annals of Surgical Oncology, 26, pp. 4397-4404. (doi: 10.1245/s10434-019-07931-6)

Laskar, P., Somani, S., Altwaijry, N., Mullin, M., Bowering, D., Warzecha, M., Keating, P., Tate, R. J., Leung, H. Y., Dufès, C. (2018) Redox-sensitive, cholesterol-bearing PEGylated poly(propylene imine)-based dendrimersomes for drug and gene delivery to cancer cells. Nanoscale, 2018, pp. 22830-22847. (doi: 10.1039/c8nr08141g)

Chaudhury, S., O'Connor, C., Cañete, A., Bittencourt-Silvestre, J., Sarrou, E., Prendergast, Á., Choi, J., Johnston, P., Wells, C. A., Gibson, B., Keeshan, K. (2018) Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias. Nature Communications, 9, (doi: 10.1038/s41467-018-07584-1)

Kim, C. S., Mohan, S., Ayub, M., Rothwell, D. G., Dive, C., Brady, G., Miller, C. (2018) In silico error correction improves cfDNA mutation calling. Bioinformatics, 35, pp. 2380-2385. (doi: 10.1093/bioinformatics/bty1004)

Salji, M., Hendry, J., Patel, A., Ahmad, I., Nixon, C., Leung, H. Y. (2018) Peri-prostatic fat volume measurement as a predictive tool for castration resistance in advanced prostate cancer. European Urology Focus, 4, pp. 858-866. (doi: 10.1016/j.euf.2017.01.019)

Chou, A. et al. (2018) Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer. Gut, 67, pp. 2142-2155. (doi: 10.1136/gutjnl-2017-315144)

Copson, E. et al. (2018) The presentation, management and outcome of inflammatory breast cancer cases in the UK: data from a multi-centre retrospective review. Breast, 42, pp. 133-141. (doi: 10.1016/j.breast.2018.09.003)

Novo, D. et al. (2018) Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nature Communications, 9, (doi: 10.1038/s41467-018-07339-y)

Chauhan, D., Bartok, E., Gaidt, M. M., Bock, F. J., Herrmann, J., Seeger, J. M., Broz, P., Beckmann, R., Kashkar, H., Tait, S. W.G., Müller, R., Hornung, V. (2018) BAX/BAK induced apoptosis results in caspase-8 dependent IL-1β maturation in macrophages. Cell Reports, 25, pp. 2354-2368.e5. (doi: 10.1016/j.celrep.2018.10.087)

Arkenau, H.-T., Italiano, A., Mak, G., Toulmonde, M., Baird, R.D., Garcia-Corbacho, J., Plummer, R., Flynn, M., Forster, M., Wilson, R.H., Tosi, D., Adenis, A., Donaldson, K., Posner, J., Kawabata, I., Arimura, A., Deva, S., Spicer, J. (2018) An extended phase Ib study of epertinib, an orally active reversible dual EGFR/HER2 tyrosine kinase inhibitor, in patients with solid tumours. European Journal of Cancer, 103, pp. 17-23. (doi: 10.1016/j.ejca.2018.07.134)

Hewit, K., Sandilands, E., Sanchez Martinez, R., James, D., Leung, H. Y., Bryant, D. M., Shanks, E., Markert, E. K. (2018) A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor. Cell Death and Disease, 9, (doi: 10.1038/s41419-018-1115-7)

Alsadeq, A., Lenk, L., Vadakumchery, A., Cousins, A., Vokuhl, C., Khadour, A., Vogiatzi, F., Seyfried, F., Meyer, L.-H., Cario, G., Hobeika, E., Debatin, K.-M., Halsey, C., Schrappe, M., Schewe, D. M., Jumaa, H. (2018) IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia. Blood, 132, pp. 1614-1617. (doi: 10.1182/blood-2018-04-844209)

Bray, T. L., Salji, M., Brombin, A., Pérez-López, A. M., Rubio-Ruiz, B., Galbraith, L. C.A., Patton, E. E., Leung, H. Y., Unciti-Broceta, A. (2018) Bright insights into palladium-triggered local chemotherapy. Chemical Science, 9, pp. 7354-7361. (doi: 10.1039/c8sc02291g)

Fleming, K., McGuinness, J., Kipgen, D., Glen, H., Spiliopoulou, P. (2018) A case of Lenvatinib-induced Focal Segmental Glomerulosclerosis (FSGS) in metastatic medullary thyroid cancer. Case Reports in Oncological Medicine, 2018, (doi: 10.1155/2018/6927639)

Mulholland, T., McAllister, M., Patek, S., Flint, D., Underwood, M., Sim, A., Edwards, J., Zagnoni, M. (2018) Drug screening of biopsy-derived spheroids using a self-generated microfluidic concentration gradient. Scientific Reports, 8, (doi: 10.1038/s41598-018-33055-0)

Roseweir, A. K., McMillan, D. C., Edwards, J. (2018) Reply to comment of "ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer" British Journal of Cancer, 119, pp. 909. (doi: 10.1038/s41416-018-0275-7)

Janjigian, Y. Y., Bendell, J., Calvo, E., Kim, J. W., Ascierto, P. A., Sharma, P., Ott, P. A., Peltola, K., Jaeger, D., Evans, J., de Braud, F., Chau, I., Harbison, C. T., Dorange, C., Tschaika, M., Le, D. T. (2018) CheckMate-032 study: efficacy and safety of nivolumab and nivolumab plus ipilimumab in patients with metastatic esophagogastric cancer. Journal of Clinical Oncology, 36, pp. 2836-2844. (doi: 10.1200/JCO.2017.76.6212)

Halsey, C. (2018) Challenging "privileged" stereotypes - leukemic blasts and the central nervous system. Leukemia Research, 73, pp. 76-77. (doi: 10.1016/j.leukres.2018.08.013)

Paul, A., Edwards, J., Pepper, C., Mackay, S. (2018) Inhibitory-κB kinase (IKK) α and nuclear factor-κB (NFκB)-inducing kinase (NIK) as anti-cancer drug targets. Cells, 7, (doi: 10.3390/cells7100176)

Salomé, M., Hopcroft, L., Keeshan, K. (2018) Inverse and correlative relationships between TRIBBLES genes indicate non-redundant functions during normal and malignant hemopoiesis. Experimental Hematology, 66, pp. 63-78.e13. (doi: 10.1016/j.exphem.2018.07.005)

Khan, K. H. et al. (2018) Longitudinal liquid biopsy and mathematical modeling of clonal evolution forecast time to treatment failure in the PROSPECT-C phase II colorectal cancer clinical trial. Cancer Discovery, 8, pp. 1270-1285. (doi: 10.1158/2159-8290.CD-17-0891)

Rust, K., Spiliopoulou, P., Tang, C. Y., Bell, C., Stirling, D., Phang, T. h. F., Davidson, R., Mackean, M., Nussey, F., Glasspool, R., Reed, N., Sadozye, A., Porteous, M., McGoldrick, T., Ferguson, M., Miedzybrodzka, Z., Mcneish, I., Gourley, C. (2018) Routine germline BRCA1 and BRCA2 testing in ovarian carcinoma patients: analysis of the Scottish real life experience. BJOG: An International Journal of Obstetrics and Gynaecology, 125, pp. 1451-1458. (doi: 10.1111/1471-0528.15171)

Lindsay, C. R. et al. (2018) Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme. ESMO Open, 3, (doi: 10.1136/esmoopen-2018-000408)

Lallo, A., Frese, K. K., Morrow, C. J., Sloane, R., Gulati, S., Schenk, M. W., Trapani, F., Simms, N., Galvin, M., Brown, S., Hodgkinson, C. L., Priest, L., Hughes, A., Lai, Z., Cadogan, E., Khandelwal, G., Simpson, K. L., Miller, C., Blackhall, F., O'Connor, M. J., Dive, C. (2018) The combination of the PARP inhibitor Olaparib and the WEE1 inhibitor AZD1775 as a new therapeutic option for small cell lung cancer. Clinical Cancer Research, 24, pp. 5153-5164. (doi: 10.1158/1078-0432.CCR-17-2805)

Foulkes, D. M., Byrne, D. P., Yeung, W., Shrestha, S., Bailey, F. P., Ferries, S., Eyers, C. E., Keeshan, K., Wells, C., Drewry, D. H., Zuercher, W. J., Kannan, N., Eyers, P. A. (2018) Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells. Science Signaling, 11, (doi: 10.1126/scisignal.aat7951)

Toofan, P., Busch, C., Morrison, H., O'Brien, S., Jørgensen, H., Copland, M., Wheadon, H. (2018) Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal. Cell Death and Disease, 9, (doi: 10.1038/s41419-018-0905-2)

Inman, G. J., Wang, J., Nagano, A., Alexandrov, L. B., Purdie, K. J., Taylor, R. G., Sherwood, V., Thomson, J., Hogan, S., Spender, L. C., South, A. P., Stratton, M., Chelala, C., Harwood, C. A., Proby, C. M., Leigh, I. M. (2018) The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature. Nature Communications, 9, (doi: 10.1038/s41467-018-06027-1)

Cross, N. C.P., White, H. W., Evans, P. A.S., Hancock, J., Copland, M., Milojkovic, D., Mason, J., Craine, S., Mead, A. J. (2018) Consensus on BCR-ABL1 reporting in chronic myeloid leukaemia in the UK. British Journal of Haematology, 182, pp. 777-788. (doi: 10.1111/bjh.15542)

Riley, J. S., Quarato, G., Cloix, C., Lopez, J., O'Prey, J., Pearson, M., Chapman, J., Sesaki, H., Carlin, L. M., Passos, J. F., Wheeler, A. P., Oberst, A., Ryan, K. M., Tait, S. W.G. (2018) Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis. EMBO Journal, 37, (doi: 10.15252/embj.201899238)

Park, J. H., Ishizuka, M., McSorley, S. T., Kubota, K., Roxburgh, C. S.D., Nagata, H., Takagi, K., Iwasaki, Y., Aoki, T., Horgan, P. G., McMillan, D. C. (2018) Staging the tumor and staging the host: A two centre, two country comparison of systemic inflammatory responses of patients undergoing resection of primary operable colorectal cancer. American Journal of Surgery, 216, pp. 458-464. (doi: 10.1016/j.amjsurg.2017.08.044)

Ianniciello, A., Rattigan, K. M., Helgason, G. V. (2018) The ins and outs of autophagy and metabolism in hematopoietic and leukemic stem cells: food for thought. Frontiers in Cell and Developmental Biology, 6, (doi: 10.3389/fcell.2018.00120)

Basu, B. et al. (2018) Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer. Annals of Oncology, 29, pp. 1918-1925. (doi: 10.1093/annonc/mdy245)

Cross, W. et al. (2018) The evolutionary landscape of colorectal tumorigenesis. Nature Ecology and Evolution, 2, pp. 1661-1672. (doi: 10.1038/s41559-018-0642-z)

Purdie, K. J., Proby, C. M., Rizvi, H., Griffin, H., Doorbar, J., Sommerlad, M., Feltkamp, M. C., Meijden, E. V. d., Inman, G. J., South, A. P., Leigh, I. M., Harwood, C. A. (2018) The role of human papillomaviruses and polyomaviruses in BRAF-inhibitor induced cutaneous squamous cell carcinoma and benign squamoproliferative lesions. Frontiers in Microbiology, 9, (doi: 10.3389/fmicb.2018.01806)

Mackay, H. L., Moore, D., Hall, C., Birkbak, N. J., Jamal-Hanjani, M., Karim, S. A., Phatak, V. M., Piñon, L., Morton, J. P., Swanton, C., Le Quesne, J., Muller, P. A.J. (2018) Genomic instability in mutant p53 cancer cells upon entotic engulfment. Nature Communications, 9, (doi: 10.1038/s41467-018-05368-1)

Krol, I., Castro-Giner, F., Maurer, M., Gkountela, S., Szczerba, B., Scherrer, R., Coleman, N., Carreira, S., Bachmann, F., Anderson, S., Engelhardt, M., Lane, H., Evans, T. R. J., Plummer, R., Kristeleit, R., Lopez, J., Aceto, N. (2018) Detection of circulating tumor cell clusters in human glioblastoma. British Journal of Cancer, 119, pp. 487-491. (doi: 10.1038/s41416-018-0186-7)

Khan, K. et al. (2018) Functional imaging and circulating biomarkers of response to regorafenib in treatment-refractory metastatic colorectal cancer patients in a prospective phase II study. Gut, 67, pp. 1484-1492. (doi: 10.1136/gutjnl-2017-314178)

Baxter, M.A., Glen, H., Evans, T.R.J. (2018) Lenvatinib and its use in the treatment of unresectable hepatocellular carcinoma. Future Oncology, 14, pp. 2021-2029. (doi: 10.2217/fon-2017-0689)

McSorley, S.T., Steele, C.W., McMahon, A.J. (2018) Meta‐analysis of oral antibiotics, in combination with preoperative intravenous antibiotics and mechanical bowel preparation the day before surgery, compared with intravenous antibiotics and mechanical bowel preparation alone to reduce surgical‐site infections in elective colorectal surgery. BJS Open, 2, pp. 185-194. (doi: 10.1002/bjs5.68)

Lua, J., Qayyum, T., Edwards, J., Roseweir, A. K. (2018) The prognostic role of the non-canonical nuclear factor-kappa B pathway in renal cell carcinoma patients. Urologia Internationalis, 101, pp. 190-196. (doi: 10.1159/000489816)

McSorley, S. T., Black, D. H., Horgan, P. G., McMillan, D. C. (2018) The relationship between tumour stage, systemic inflammation, body composition and survival in patients with colorectal cancer. Clinical Nutrition, 37, pp. 1279-1285. (doi: 10.1016/j.clnu.2017.05.017)

Wilson, R., Osborne, C., Halsey, C. (2018) The use of Ommaya reservoirs to deliver central nervous system directed chemotherapy in childhood acute lymphoblastic leukaemia. Pediatric Drugs, 20, pp. 293-301. (doi: 10.1007/s40272-018-0298-9)

Gujam, F., Dickson, K., McCall, P., McMillan, D., Edwards, J. (2018) The relationship between androgen receptor, components of tumour microenvironment and survival in breast cancer molecular subtypes. Cancer Therapy and Oncology, 11,

Roseweir, A. K., Halcrow, E. S., Chichilo, S., Powell, A. G.M.T., McMillan, D. C., Horgan, P. G., Edwards, J. (2018) ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer. British Journal of Cancer, 119, pp. 323-329. (doi: 10.1038/s41416-018-0174-y)

Warren, S. C., Nobis, M., Magenau, A., Mohammed, Y. H., Herrmann, D., Moran, I., Vennin, C., Conway, J. R.W., Mélénec, P., Cox, T. R., Wang, Y., Morton, J. P., Welch, H. C.E., Strathdee, D., Anderson, K. I., Phan, T. G., Roberts, M. S., Timpson, P. (2018) Removing physiological motion from intravital and clinical functional imaging data. eLife, 7, (doi: 10.7554/elife.35800)

Dolan, R. D., McSorley, S. T., Park, J. H., Watt, D. G., Roxburgh, C. S., Horgan, P. G., McMillan, D. C. (2018) The prognostic value of systemic inflammation in patients undergoing surgery for colon cancer: comparison of composite ratios and cumulative scores. British Journal of Cancer, 119, pp. 40-51. (doi: 10.1038/s41416-018-0095-9)

McSorley, S. T., Talwar, D., McMillan, D. C. (2018) Comment on the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. American Journal of Clinical Nutrition, 108, pp. 204-205. (doi: 10.1093/ajcn/nqx071)

Newcombe, A. A., Gibson, B. E.S., Keeshan, K. (2018) Harnessing the potential of epigenetic therapies for childhood acute myeloid leukemia. Experimental Hematology, 63, pp. 1-11. (doi: 10.1016/j.exphem.2018.03.008)

Muthalagu, N., Murphy, D. J. (2018) Is oxidative stress MYC’s Achilles heel? Cell Death and Differentiation, 25, pp. 1189-1190. (doi: 10.1038/s41418-018-0117-4)

Patel, M., Horgan, P. G., McMillan, D. C., Edwards, J. (2018) NF-κB pathways in the development and progression of colorectal cancer. Translational Research, 197, pp. 43-56. (doi: 10.1016/j.trsl.2018.02.002)

Torres-Ayuso, P., Sahoo, S., Ashton, G., An, E., Simms, N., Galvin, M., Leong, H. S., Frese, K. K., Simpson, K., Cook, N., Hughes, A., Miller, C. J., Marais, R., Dive, C., Krebs, M. G., Brognard, J. (2018) Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin. npj Genomic Medicine, 3, (doi: 10.1038/s41525-018-0055-6)

Kruspig, B., Monteverde, T., Neidler, S., Hock, A., Kerr, E., Nixon, C., Clark, W., Hedley, A., Laing, S., Coffelt, S. B., Le Quesne, J., Dick, C., Vousden, K., Martins, C. P., Murphy, D. J. (2018) The ERBB network facilitates KRAS-driven lung tumorigenesis. Science Translational Medicine, 10, (doi: 10.1126/scitranslmed.aao2565)

McSorley, S. T., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. C. (2018) The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer. Perioperative Medicine, 7, (doi: 10.1186/s13741-018-0093-8)

Conway, J. R.W. et al. (2018) Intravital imaging to monitor therapeutic response in moving hypoxic regions resistant to PI3K pathway targeting in pancreatic cancer. Cell Reports, 23, pp. 3312-3326. (doi: 10.1016/j.celrep.2018.05.038)

Allen, W. L. et al. (2018) Transcriptional subtyping and CD8 immunohistochemistry identifies patients with stage II and III colorectal cancer with poor prognosis who benefit from adjuvant chemotherapy. JCO Precision Oncology, pp. 1-15. (doi: 10.1200/PO.17.00241)

Godfrey, J. D., Morton, J. P., Wilczynska, A., Sansom, O. J., Bushell, M. D. (2018) MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus. Cell Death and Disease, 9, (doi: 10.1038/s41419-018-0628-4)

Saraggi, D., Galuppini, F., Fanelli, G. N., Remo, A., Urso, E. D.L., Bao, R. Q., Bacchin, D., Guzzardo, V., Luchini, C., Braconi, C., Farinati, F., Rugge, M., Fassan, M. (2018) MiR-21 up-regulation in ampullary adenocarcinoma and its pre-invasive lesions. Pathology: Research and Practice, 214, pp. 835-839. (doi: 10.1016/j.prp.2018.04.018)

Roseweir, A. K., Bennett, L., Dickson, A., Cheng, K., Quintayo, M.-A., Bayani, J., McMillan, D. C., Horgan, P. G., van de Velde, C. J.H., Seynaeve, C., Hasenburg, A., Kieback, D. G., Markopoulos, C., Dirix, L. Y., Rea, D. W., Mallon, E. A., Bartlett, J. M.S., Edwards, J. (2018) Predictive biomarkers for endocrine therapy: retrospective study in Tamoxifen and Exemestane Adjuvant Multinational (TEAM) trial. Journal of the National Cancer Institute, 110, pp. 616-627. (doi: 10.1093/jnci/djx255)

Martin, G. A., Tsim, S., Kidd, A. C., Foster, J. E., McLoone, P., Chalmers, A., Blyth, K. G. (2018) Pre-EDIT: protocol for a randomised feasibility trial of elastance-directed intrapleural catheter or talc pleurodesis (EDIT) in malignant pleural effusion. BMJ Open Respiratory Research, 5, (doi: 10.1136/bmjresp-2018-000293)

Candido, J. B. et al. (2018) CSF1R+ macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype. Cell Reports, 23, pp. 1448-1460. (doi: 10.1016/j.celrep.2018.03.131)

Salomé, M., Magee, A., Yalla, K., Chaudhury, S., Sarrou, E., Carmody, R. J., Keeshan, K. (2018) A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling. Cell Death and Disease, 9, (doi: 10.1038/s41419-018-0467-3)

Port, J. et al. (2018) Colorectal tumors require NUAK1 for protection from oxidative stress. Cancer Discovery, 8, pp. 632-647. (doi: 10.1158/2159-8290.CD-17-0533)

Forster, V., Escherich, G., Halsey, C. (2018) Comment on: Successful use of nitrous oxide during lumbar punctures: a call for nitrous oxide in pediatric oncology clinics. Pediatric Blood and Cancer, 65, (doi: 10.1002/pbc.26930)

Galbraith, L., Leung, H. Y., Ahmad, I. (2018) Lipid pathway deregulation in advanced prostate cancer. Pharmacological Research, 131, pp. 177-184. (doi: 10.1016/j.phrs.2018.02.022)

Convertino, M., Church, T. R., Olsen, G. W., Liu, Y., Doyle, E., Elcombe, C. R., Barnett, A. L., Samuel, L. M., MacPherson, I. R., Evans, T. R.J. (2018) Stochastic pharmacokinetic-pharmacodynamic modeling for assessing the systemic health risk of perfluorooctanoate (PFOA) Toxicological Sciences, 163, pp. 293-306. (doi: 10.1093/toxsci/kfy035)

Campbell, K. J., Tait, S. W.J. (2018) Targeting BCL-2 regulated apoptosis in cancer. Open Biology, 8, (doi: 10.1098/rsob.180002)

Mitchell, R., Hopcroft, L. E.M., Baquero, P., Allan, E. K., Hewit, K., James, D., Hamilton, G., Mukhopadhyay, A., O'Prey, J., Hair, A., Melo, J. V., Chan, E., Ryan, K. M., Maguer-Satta, V., Druker, B. J., Clark, R. E., Mitra, S., Herzyk, P., Nicolini, F. E., Salomoni, P., Helgason, G. V. (2018) Targeting BCR-ABL independent TKI resistance in chronic myeloid leukaemia by mTOR and autophagy inhibition. Journal of the National Cancer Institute, 110, pp. 467-478. (doi: 10.1093/jnci/djx236)

McSorley, S. T., Khor, B. Y., Tsang, K., Colville, D., Han, S., Horgan, P. G., McMillan, D. C. (2018) The relationship between 18F FDG-PETCT derived markers of tumour metabolism and systemic inflammation in patients with recurrent disease following surgery for colorectal cancer. Colorectal Disease, 20, pp. 407-415. (doi: 10.1111/codi.13973)

Carvajal, R. D. et al. (2018) Selumetinib in combination with dacarbazine in patients with metastatic uveal melanoma: a phase III, multicentre, randomised trial (SUMIT) Journal of Clinical Oncology, 36, pp. 1232-1239. (doi: 10.1200/JCO.2017.74.1090)

Hudson, A. M., Stephenson, N. L., Li, C., Trotter, E., Fletcher, A. J., Katona, G., Bieniasz-Krzywiec, P., Howell, M., Wirth, C., Furney, S., Miller, C. J., Brognard, J. (2018) Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases. Science Signaling, 11, (doi: 10.1126/scisignal.aan6776)

Meiser, J., Schuster, A., Pietzke, M., Voore, J. V., Athineos, D., Oizel, K., Burgos-Barragan, G., Wit, N., Dhayade, S., Morton, J. P., Dornier, E., Sumpton, D., Mackay, G. M., Blyth, K., Patel, K. J., Niclou, S. P., Vazquez, A. (2018) Increased formate overflow is a hallmark of oxidative cancer. Nature Communications, 9, (doi: 10.1038/s41467-018-03777-w)

Pellicano, F., Park, L., Hopcroft, L. E.M., Shah, M. M., Jackson, L., Scott, M. T., Clarke, C. J., Sinclair, A., Abraham, S. A., Hair, A., Helgason, G. V., Aspinall-O'Dea, M., Bhatia, R., Leone, G., Kranc, K. R., Whetton, A. D., Holyoake, T. L. (2018) Hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival. Blood, 131, pp. 1532-1544. (doi: 10.1182/blood-2017-05-783845)

Patel, R., Fleming, J., Mui, E., Loveridge, C., Repiscak, P., Blomme, A., Harle, V., Salji, M., Ahmad, I., Teo, K., Hamdy, F. C., Hedley, A., van den Broek, N., Mackay, G., Edwards, J., Sansom, O. J., Leung, H. Y. (2018) Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1. EMBO Molecular Medicine, 10, (doi: 10.15252/emmm.201708347)

Zhang, B. et al. (2018) Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia. Nature Medicine, 24, pp. 450-462. (doi: 10.1038/nm.4499)

Tsim, S., Humphreys, C. A., Cowell, G. W., Stobo, D. B., Noble, C., Woodward, R., Kelly, C. A., Alexander, L., Foster, J. E., Dick, C., Blyth, K. G. (2018) Early Contrast Enhancement: a novel Magnetic Resonance Imaging biomarker of pleural malignancy. Lung Cancer, 118, pp. 48-56. (doi: 10.1016/j.lungcan.2018.01.014)

De Santo, C., Booth, S., Vardon, A., Cousins, A., Tubb, V., Perry, T., Noyvert, B., Beggs, A., Ng, M., Halsey, C., Kearns, P., Cheng, P., Mussai, F. (2018) The arginine metabolome in Acute Lymphoblastic Leukemia can be targeted by the PEG-recombinant Arginase I BCT-100. International Journal of Cancer, 142, pp. 1490-1502. (doi: 10.1002/ijc.31170)

Kudo, M., Finn, R., Qin, S., Han, K.-H., Ikeda, K., Piscaglia, F., Baron, A., Park, J.-W., Han, G., Jassem, J., Blanc, J. F., Vogel, A., Komov, D., Evans, J., Lopez, C., Dutcus, C., Guo, M., Saito, K., Kraljevic, S., Tamai, T., Ren, M., Cheng, A.-L. (2018) Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial. Lancet, 391, pp. 1163-1173. (doi: 10.1016/S0140-6736(18)30207-1)

Sinclair, P. B., Blair, H. H., Ryan, S. L., Buechler, L., Cheng, J., Clayton, J., Hanna, R., Hollern, S., Hawking, Z., Bashton, M., Schwab, C. J., Jones, L., Russell, L. J., Marr, H., Carey, P., Halsey, C., Heidenreich, O., Moorman, A. V., Harrison, C. J. (2018) Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. Haematologica, 103, pp. 634-644. (doi: 10.3324/haematol.2017.172304)

Marchetti, C., Zyner, K. G., Ohnmacht, S. A., Robson, M., Haider, S. M., Morton, J. P., Marsico, G., Vo, T., Laughlin-Toth, S., Ahmed, A. A., Di Vita, G., Pazitna, I., Gunaratnam, M., Besser, R. J., Andrade, A. C.G., Diocou, S., Pike, J. A., Tannahill, D., Pedley, R. B., Evans, T.R. J., Wilson, W. D., Balasubramanian, S., Neidle, S. (2018) Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule. Journal of Medicinal Chemistry, 61, pp. 2500-2517. (doi: 10.1021/acs.jmedchem.7b01781)

Woodcock, V. K., Clive, S., Wilson, R. H., Coyle, V. M., Stratford, M. R. L., Folkes, L. K., Eastell, R., Barton, C., Jones, P., Kazmi-Stokes, S., Turner, H., Halford, S., Harris, A. L., Middleton, M. R. (2018) A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424. British Journal of Cancer, 118, pp. 770-776. (doi: 10.1038/bjc.2017.484)

Cook, N., Basu, B., Smith, D.-M., Gopinathan, A., Evans, T.R. J., Steward, W. P., Palmer, D., Propper, D., Venugopal, B., Hategan, M., Anthoney, D. A., Hampson, L. V., Nebozhyn, M., Tuveson, D., Farmer-Hall, H., Turner, H., McLeod, R., Halford, S., Jodrell, D. (2018) A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma. British Journal of Cancer, 118, pp. 793-801. (doi: 10.1038/bjc.2017.495)

O'Connor, C., Yalla, K., Salome, M., Moka, H. A., Gómez Castañeda, E., Eyers, P. A., Keeshan, K. (2018) Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2. Oncotarget, 9, pp. 14977-14992. (doi: 10.18632/oncotarget.24525)

Rose, A. M., Spender, L. C., Stephen, C., Mitchell, A., Rickaby, W., Bray, S., Evans, A. T., Dayal, J., Purdie, K. J., Harwood, C. A., Proby, C. M., Leigh, I. M., Coates, P. J., Inman, G. j. (2018) Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma. Oncotarget, 9, pp. 14552-14566. (doi: 10.18632/oncotarget.24545)

McSorley, S. T., Mansouri, D., Horgan, P. G., McMillan, D. C. (2018) Comment on "the important role for intravenous iron in perioperative patient blood management in major abdominal surgery: a randomized controlled trial" Annals of Surgery, 267, pp. e49. (doi: 10.1097/SLA.0000000000002053)

Dolan, R., McSorley, S. T., Horgan, P. G., McMillan, D. C. (2018) Determinants of lymph node count and positivity in patients undergoing surgery for colon cancer. Medicine, 97, (doi: 10.1097/MD.0000000000010185)

Munje, C., Copland, M. (2018) Exploring stem cell heterogeneity in chronic myeloid leukemia. Trends in Cancer, 4, pp. 167-169. (doi: 10.1016/j.trecan.2017.12.001)

Bartram, J., Goulden, N., Wright, G., Adams, S., Brooks, T., Edwards, D., Inglott, S., Yousafzai, Y., Hubank, M., Halsey, C. (2018) High throughput sequencing in acute lymphoblastic leukemia reveals clonal architecture of central nervous system and bone marrow compartments. Haematologica, 103, (doi: 10.3324/haematol.2017.174987)

Adams, R., Brown, E., Brown, L., Butler, R., Falk, S., Fisher, D., Kaplan, R., Quirke, P., Richman, S., Samuel, L., Seligmann, J., Seymour, M., Shiu, K. K., Wasan, H., Wilson, R., Maughan, T. (2018) Inhibition of EGFR, HER2, and HER3 signalling in patients with colorectal cancer wild-type for BRAF, PIK3CA, KRAS , and NRAS (FOCUS4-D): a phase 2–3 randomised trial. Lancet Gastroenterology and Hepatology, 3, pp. 162-171. (doi: 10.1016/S2468-1253(17)30394-1)

Lampis, A. et al. (2018) MIR21 drives resistance to heat shock protein 90 inhibition in cholangiocarcinoma. Gastroenterology, 154, pp. 1066-1079.e5. (doi: 10.1053/j.gastro.2017.10.043)

Galluzzi, L. et al. (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation, 25, pp. 486-541. (doi: 10.1038/s41418-017-0012-4)

Vennin, C., Murphy, K. J., Morton, J. P., Cox, T. R., Pajic, M., Timpson, P. (2018) Reshaping the tumor stroma for treatment of pancreatic cancer. Gastroenterology, 154, pp. 820-838. (doi: 10.1053/j.gastro.2017.11.280)

Patel, M., McSorley, S. T., Park, J. H., Roxburgh, C. S.D., Edwards, J., Horgan, P. G., McMillan, D. C. (2018) The relationship between right-sided tumour location, tumour microenvironment, systemic inflammation, adjuvant therapy and survival in patients undergoing surgery for colon and rectal cancer. British Journal of Cancer, 118, pp. 705-712. (doi: 10.1038/bjc.2017.441)

Vlachogiannis, G. et al. (2018) Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science, 359, pp. 920-926. (doi: 10.1126/science.aao2774)

Monteverde, T., Tait-Mulder, J., Hedley, A.,, Knight, J.R., Sansom, O.J., Murphy, D.J. (2018) Calcium signalling links MYC to NUAK1. Oncogene, 37, pp. 982-992. (doi: 10.1038/onc.2017.394)

Wilson, R. A.M., Evans, T.R. J., Fraser, A. R., Nibbs, R. J.B. (2018) Immune checkpoint inhibitors: new strategies to checkmate cancer. Clinical and Experimental Immunology, 191, pp. 133-148. (doi: 10.1111/cei.13081)

Schofield, H. K., Zeller, J., Espinoza, C., Halbrook, C. J., Del Vecchio, A., Magnuson, B., Fabo, T., Daylan, A. E. C., Kovalenko, I., Lee, H.-J., Yan, W., Feng, Y., Karim, S. A., Kremer, D. M., Kumar-Sinha, C., Lyssiotis, C. A., Ljungman, M., Morton, J. P., Galbán, S., Fearon, E. R., Pasca di Magliano, M. (2018) Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma. JCI Insight, 3, (doi: 10.1172/jci.insight.97422)

Sclafani, F., Chau, I., Cunningham, D., Hahne, J. C., Vlachogiannis, G., Eltahir, Z., Lampis, A., Braconi, C., Kalaitzaki, E., De Castro, D. G., Wotherspoon, A., Capdevila, J., Glimelius, B., Tarazona, N., Begum, R., Lote, H., Hulkki Wilson, S., Mentrasti, G., Brown, G., Tait, D., Oates, J., Valeri, N. (2018) KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer. Scientific Reports, 8, (doi: 10.1038/s41598-018-19212-5)

Campbell, K. J., Dhayade, S., Ferrari, N., Sims, A. H., Johnson, E., Mason, S. M., Dickson, A., Ryan, K. M., Kalna, G., Edwards, J., Tait, S. G.W., Blyth, K. (2018) MCL-1 is a prognostic indicator and drug target in breast cancer. Cell Death and Disease, 9, (doi: 10.1038/s41419-017-0035-2)

Morrison, A., Marshall-Mckenna, R., Hutchison, C., MacPherson, I., Rice, A.M., McFadyen, A.K. (2018) Taxane Chemotherapy and Nail Toxicity in Women with Breast Cancer: An Evaluation of Interventions.

Morrison, A., Marshall-Mckenna, R., Hutchison, C., MacPherson, I., Rice, A.M., McFadyen, A.K. (2018) The NTOX-G12- A New Clinical Assessment Tool for Nail Problems as a Result of Taxane Chemotherapy Regimens.

Hurst, L. A., Dunmore, B. J., Long, L., Crosby, A., Al-Lamki, R., Deighton, J., Southwood, M., Yang, X., Nikolic, M. Z., Herrera, B., Inman, G. J., Bradley, J. R., Rana, A. A., Upton, P. D., Morrell, N. W. (2018) TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nature Communications, 8, (doi: 10.1038/ncomms14079)

Haughney, J., Morice, A., Blyth, K. G., Lee, A. J., Coutts, A., McKnight, E., Pavord, I. (2018) A retrospective cohort study in severe asthma describing commonly measured biomarkers: Eosinophil count and IgE levels. Respiratory Medicine, 134, pp. 117-123. (doi: 10.1016/j.rmed.2017.12.001)

Dreyer, S.B., Jamieson, N.B., Upstill-Goddard, R., Bailey, P.J., McKay, C.J., Australian Pancreatic Cancer Genome Initiative, , Biankin, A.V., Chang, D.K. (2018) Defining the molecular pathology of pancreatic body and tail adenocarcinom. British Journal of Surgery, 105, pp. e183-e191. (doi: 10.1002/bjs.10772)

Sharma, V., Blyth, K. G. (2018) Empyema necessitans and a persistent air leak associated with rupture of an anaerobic lung abscess due to bacteroides. Thorax, 73, pp. 91-93. (doi: 10.1136/thoraxjnl-2017-210462)

Cherrie, J. W., McElvenny, D., Blyth, K. G. (2018) Estimating past inhalation exposure to asbestos: a tool for risk attribution and disease screening. International Journal of Hygiene and Environmental Health, 221, pp. 27-32. (doi: 10.1016/j.ijheh.2017.09.013)

Moorcraft, S. Y., Gonzalez de Castro, D., Cunningham, D., Jones, T., Walker, B. A., Peckitt, C., Yuan, L. C., Frampton, M., Begum, R., Eltahir, Z., Wotherspoon, A., Teixeira Mendes, L. S., Hulkki Wilson, S., Gillbanks, A., Baratelli, C., Fotiadis, N., Patel, A., Braconi, C., Valeri, N., Gerlinger, M., Rao, S., Watkins, D., Chau, I., Starling, N. (2018) Investigating the feasibility of tumour molecular profiling in gastrointestinal malignancies in routine clinical practice. Annals of Oncology, 29, pp. 230-236. (doi: 10.1093/annonc/mdx631)

Blyth, K. G., Murphy, D. J. (2018) Progress and challenges in Mesothelioma: from bench to bedside. Respiratory Medicine, 134, pp. 31-41. (doi: 10.1016/j.rmed.2017.11.015)

Kidd, A. C., McGettrick, M., Tsim, S., Halligan, D. L., Bylesjo, M., Blyth, K. G. (2018) Survival prediction in mesothelioma using a scalable lasso regression model: instructions for use and initial performance using clinical predictors. BMJ Open Respiratory Research, 5, (doi: 10.1136/bmjresp-2017-000240)

Almasaudi, A. S., McSorley, S. T., Edwards, C. A., McMillan, D. C. (2018) The relationship between body mass index and short term postoperative outcomes in patients undergoing potentially curative surgery for colorectal cancer: a systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 121, pp. 68-73. (doi: 10.1016/j.critrevonc.2017.12.004)

Bilsland, A., Kelly, C., Roccisana, J., Paul, J., Jones, R., Edwards, J., Roseweir, A., Stein, T., West, K. (2018) An Exploratory Study on the Use of Game-based Learning Using Microsoft Kinect to Teach Oncology Phase I Clinical Trial Designs. (doi: 10.1038/s41416-018-0299-z)

Cao, K., Tait, S. W.G. (2018) Apoptosis and cancer: force awakens, phantom menace, or both? Elsevier

de Beauchamp, L., Baquero, P., Kuntz, E. M., Gottlieb, E., Helgason, G. V. (2018) Auto-commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells” Molecular and Cellular Oncology, 5, (doi: 10.1080/23723556.2017.1403532)

Giampazolias, E., Tait, S. W.G. (2018) Caspase-independent cell death: an anti-cancer double-whammy. Cell Cycle, 17, pp. 269-270. (doi: 10.1080/15384101.2017.1408229)

Dolan, R., Tilling, E., Kong, C. Y., MacLeod, N. J., McSorley, S. T., Park, J. H., Glen, P., Horgan, P. G., Laird, B., McMillan, D. C. (2018) Evaluation of Systemic Inflammation Based Prognostic Scores in Patients with Advanced Oesophageal Cancer Receiving Palliative Radiotherapy.

Sierra Gonzalez, P., O'Prey, J., Cardaci, S., Barthet, V. J.A., Sakamaki, J.-i., Beaumatin, F., Roseweir, A., Gay, D. M., Mackay, G., Malviya, G., Kania, E., Ritchie, S., Baudot, A. D., Zunino, B., Mrowinska, A., Nixon, C., Ennis, D., Hoyle, A., Millan, D., Mcneish, I. A., Sansom, O. J., Edwards, J., Ryan, K. M. (2018) Mannose impairs tumour growth and enhances chemotherapy. Nature, 563, pp. 719-723. (doi: 10.1038/s41586-018-0729-3)

McClurg, U. L., Chit, N. C.T.H., Azizyan, M., Edwards, J., Nabbi, A., Riabowol, K. T., Nakjang, S., McCracken, S. R., Robson, C. N. (2018) Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12. Oncogene, 37, pp. 4679-4691. (doi: 10.1038/s41388-018-0283-3)

Bennett, L., Howell, M., Memon, D., Smowton, C., Zhou, C., Miller, C. J. (2018) Mutation pattern analysis reveals polygenic mini-drivers associated with relapse after surgery in lung adenocarcinoma. Scientific Reports, 8, (doi: 10.1038/s41598-018-33276-3)

Evison, M., Blyth, K. G., Bhatnagar, R., Corcoran, J., Saba, T., Duncan, T., Hallifax, R., Ahmed, L., West, A., Pepperell, J. C. T., Roberts, M., Sivasothy, P., Psallidas, I., Clive, A. O., Latham, J., Stanton, A. E., Maskell, N., Rahman, N. (2018) Providing safe and effective pleural medicine services in the UK: an aspirational statement from UK pleural physicians. BMJ Open Respiratory Research, 5, (doi: 10.1136/bmjresp-2018-000307)

Altwaijry, N., Somani, S., Parkinson, J. A., Tate, R. J., Keating, P., Warzecha, M., Mackenzie, G. R., Leung, H. Y., Dufès, C. (2018) Regression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-α, TRAIL, and interleukin-12. Drug Delivery, 25, pp. 679-689. (doi: 10.1080/10717544.2018.1440666)

Dolan, R., McSorley, S. T., Park, J. H., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. C. (2018) The Prognostic Value of Systemic Inflammation in Patients Undergoing Surgery for Rectal Cancer: Comparison of Composite Ratios and Cumulative Scores. (doi: 10.1200/JCO.2018.36.4_suppl.579)

Dornier, E., Rabas, N., Mitchell, L., Novo, D., Dhayade, S., Marco, S., Mackay, G., Sumpton, D., Pallares, M., Nixon, C., Blyth, K., MacPherson, I. R., Rainero, E., Norman, J. C. (2017) Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells. Nature Communications, 8, (doi: 10.1038/s41467-017-02101-2)

Lawler, M., Alsina, D., Adams, R. A., Anderson, A. S., Brown, G., Fearnhead, N. S., Fenwick, S. W., Halloran, S. P., Hochhauser, D., Hull, M. A., Koelzer, V. H., McNair, A. G.K., Monahan, K. J., Näthke, I., Norton, C., Novelli, M. R., Steele, R. J.C., Thomas, A. L., Wilde, L. M., Wilson, R. H., Tomlinson, I. (2017) Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer. Gut, 67, pp. 179-193. (doi: 10.1136/gutjnl-2017-315333)

Rumney, R. M.H., Coffelt, S. B., Neale, T. A., Dhayade, S., Tozer, G. M., Miller, G. (2017) PyMT-Maclow: A novel, inducible, murine model for determining the role of CD68 positive cells in breast tumor development. PLoS ONE, 12, (doi: 10.1371/journal.pone.0188591)

Walton, J. B., Farquharson, M., Mason, S., Port, J., Kruspig, B., Dowson, S., Stevenson, D., Murphy, D., Matzuk, M., Kim, J., Coffelt, S., Blyth, K., Mcneish, I. A. (2017) CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity. Scientific Reports, 7, (doi: 10.1038/s41598-017-17119-1)

Conway, J. R.W., Vennin, C., Cazet, A. S., Herrmann, D., Murphy, K. J., Warren, S. C., Wullkopf, L., Boulghourjian, A., Zaratzian, A., Da Silva, A. M., Pajic, M., Morton, J. P., Cox, T. R., Timpson, P. (2017) Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology. Scientific Reports, 7, (doi: 10.1038/s41598-017-17177-5)

Dolan, R. D., Lim, J., Mcsorley, S. T., Horgan, P. G., McMillan, D. C. (2017) The role of the systemic inflammatory response in predicting outcomes in patients with operable cancer: Systematic review and meta-analysis. Scientific Reports, 7, (doi: 10.1038/s41598-017-16955-5)

Lindner, A. U., Salvucci, M., Morgan, C., Monsefi, N., Resler, A. J., Cremona, M., Curry, S., Toomey, S., O'Byrne, R., Bacon, O., Stühler, M., Flanagan, L., Wilson, R., Johnston, P. G., Salto-Tellez, M., Camilleri-Broët, S., McNamara, D. A., Kay, E. W., Hennessy, B. T., Laurent-Puig, P., Van Schaeybroeck, S., Prehn, J. H.M. (2017) BCL-2 system analysis identifies high-risk colorectal cancer patients. Gut, 66, pp. 2141-2148. (doi: 10.1136/gutjnl-2016-312287)

Cousins, A., Markert, E., Degn, M., Olivares, O., Yousafzai, Y. M., Bhatti, S., Herzyk, P., Michie, A., Schmiegelow, K., Gottlieb, E., Halsey, C. (2017) Upregulated cholesterol biosynthesis is a biomarker for isolated central nervous system relapse in acute lymphoblastic leukaemia. Blood, 130,

Hall, P. S., Smith, A., Hulme, C., Vargas-Palacios, A., Makris, A., Hughes-Davies, L., Dunn, J. A., Bartlett, J. M.S., Cameron, D. A., Marshall, A., Campbell, A., Macpherson, I. R., Rea, D., Francis, A., Earl, H., Morgan, A., Stein, R. C., McCabe, C. (2017) Value of information analysis of multiparameter tests for chemotherapy in early breast cancer: the OPTIMA prelim trial. Value in Health, 20, pp. 1311-1318. (doi: 10.1016/j.jval.2017.04.021)

Lewis, M., Copland, M., Soverini, S., Sadovnik, I., Bedel, A., Prost, S., Italiano, A., Mahon, F.-X. (2017) What are the challenges in 2016 regarding resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and cancer? Hematological Oncology, 35, pp. 420-423. (doi: 10.1002/hon.2329)

Farrell, A. S. et al. (2017) MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nature Communications, 8, (doi: 10.1038/s41467-017-01967-6)

Port, J., Murphy, D. J. (2017) Mesothelioma: identical routes to malignancy from asbestos and carbon nanotubes. Current Biology, 27, pp. R1173-R1176. (doi: 10.1016/j.cub.2017.07.026)

Ghidini, M., Cascione, L., Carotenuto, P., Lampis, A., Trevisani, F., Previdi, M. C., Hahne, J. C., Said-Huntingford, I., Raj, M., Zerbi, A., Mescoli, C., Cillo, U., Rugge, M., Roncalli, M., Torzilli, G., Rimassa, L., Santoro, A., Valeri, N., Fassan, M., Braconi, C. (2017) Characterisation of the immune-related transcriptome in resected biliary tract cancers. European Journal of Cancer, 86, pp. 158-165. (doi: 10.1016/j.ejca.2017.09.005)

Schrock, A. B., Devoe, C. E., McWilliams, R., Sun, J., Aparicio, T., Stephens, P. J., Ross, J. S., Wilson, R., Miller, V. A., Ali, S. M., Overman, M. J. (2017) Genomic profiling of small-bowel adenocarcinoma. JAMA Oncology, 3, pp. 1546. (doi: 10.1001/jamaoncol.2017.1051)

Alvi, M. A., Wilson, R. H., Salto-Tellez, M. (2017) Rare cancers: the greatest inequality in cancer research and oncology treatment. British Journal of Cancer, 117, pp. 1255-1257. (doi: 10.1038/bjc.2017.321)

Graham, J., Spiliopoulou, P., Arbuckle, R., Bridge, J. A., Cassidy, J. (2017) A pilot study of subjective well-being in colorectal cancer patients and their caregivers. Patient Related Outcome Measures, 8, pp. 111-119. (doi: 10.2147/PROM.S141815)

Loveridge, C. J., van ’t Hof, R. J., Charlesworth, G., King, A., Tan, E. H., Rose, L., Daroszewska, A., Prior, A., Ahmad, I., Welsh, M., Mui, E. J., Ford, C., Salji, M., Sansom, O., Blyth, K., Leung, H. Y. (2017) Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity. Scientific Reports, 7, (doi: 10.1038/s41598-017-13346-8)

Munkley, J., Oltean, S., Vodák, D., Wilson, B. T., Livermore, K. E., Zhou, Y., Star, E., Floros, V. I., Johannessen, B., Knight, B., McCullagh, P., McGrath, J., Crundwell, M., Skotheim, R. I., Robson, C. N., Leung, H. Y., Harries, L. W., Rajan, P., Mills, I. G., Elliott, D. J. (2017) The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer. Oncotarget, 6, pp. 34358-34374. (doi: 10.18632/oncotarget.6024)

Nobis, M. et al. (2017) A RhoA-FRET biosensor mouse for intravital imaging in normal tissue homeostasis and disease contexts. Cell Reports, 21, pp. 274-288. (doi: 10.1016/j.celrep.2017.09.022)

Cain, H., MacPherson, I.R., Beresford, M., Pinder, S.E., Pong, J., Dixon, J.M. (2017) Neoadjuvant therapy in early breast cancer: treatment considerations and common debates in practice. Clinical Oncology, 29, pp. 642-652. (doi: 10.1016/j.clon.2017.06.003)

Cammareri, P., Vincent, D. F., Hodder, M. C., Ridgway, R. A., Murgia, C., Nobis, M., Campbell, A. D., Varga, J., Huels, D. J., Subramani, C., Prescott, K. L.H., Nixon, C., Hedley, A., Barry, S. T., Greten, F. R., Inman, G. J., Sansom, O. J. (2017) TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis. Cell Death and Differentiation, 24, pp. 1681-1693. (doi: 10.1038/cdd.2017.92)

Kuntz, E. M., Baquero, P., Michie, A. M., Dunn, K., Tardito, S., Holyoake, T. L., Helgason, G. V., Gottlieb, E. (2017) Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells. Nature Medicine, 23, pp. 1234-1240. (doi: 10.1038/nm.4399)

Laing, A. A., Harrison, C. J., Gibson, B. E.S., Keeshan, K. (2017) Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukaemia. Experimental Hematology, 54, pp. 40-50. (doi: 10.1016/j.exphem.2017.06.007)

Villa, E., Proïcs, E., Rubio-Patiño, C., Obba, S., Zunino, B., Bossowski, J. P., Rozier, R. M., Chiche, J., Mondragón, L., Riley, J. S., Marchetti, S., Verhoeyen, E., Tait, S. W.G., Ricci, J.-E. (2017) Parkin-independent mitophagy controls chemotherapeutic response in cancer cells. Cell Reports, 20, pp. 2846-2859. (doi: 10.1016/j.celrep.2017.08.087)

Chiu, A., Ayub, M., Dive, C., Brady, G., Miller, C. J., Hancock, J. (2017) twoddpcr: an R/Bioconductor package and Shiny app for Droplet Digital PCR analysis. Bioinformatics, 33, pp. 2743-2745. (doi: 10.1093/bioinformatics/btx308)

Sarrou, E., Gibson, B., Keeshan, K. (2017) Absence of Mcm6 mimics haemopoietic ageing and has implications for leukaemic transformation. (doi: 10.1016/j.exphem.2017.06.134)

Chuvin, N. et al. (2017) Acinar-to-ductal metaplasia induced by transforming growth factor beta facilitates KRAS(G12D)-driven pancreatic tumorigenesis. Cellular and Molecular Gastroenterology and Hepatology, 4, pp. 263-282. (doi: 10.1016/j.jcmgh.2017.05.005)

Ghidini, M., Tomasello, G., Botticelli, A., Barni, S., Zabbialini, G., Seghezzi, S., Passalacqua, R., Braconi, C., Petrelli, F. (2017) Adjuvant chemotherapy for resected biliary tract cancers: a systematic review and meta-analysis. HPB, 19, pp. 741-748. (doi: 10.1016/j.hpb.2017.05.010)

Dolan, R. D., McSorley, S. T., McMillan, D. C., Horgan, P. G. (2017) Attitudes of surgeons to the use of postoperative markers of the systemic inflammatory response following elective surgery. Annals of Medicine and Surgery, 21, pp. 14-19. (doi: 10.1016/j.amsu.2017.07.046)

Watt, D. G., Ramanathan, M. L., McSorley, S. T., Walley, K., Park, J. H., Horgan, P. G., McMillan, D. C. (2017) Clinicopathological determinants of an elevated systemic inflammatory response following elective potentially curative resection for colorectal cancer. Annals of Surgical Oncology, 24, pp. 2588-2594. (doi: 10.1245/s10434-017-5987-z)

Giampazolias, E. et al. (2017) Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nature Cell Biology, 19, pp. 1116-1129. (doi: 10.1038/ncb3596)

Murphy, D. J., Blyth, K. G. (2017) Predicting lung cancer recurrence from circulating tumour DNA. Commentary on 'Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution' Cell Death and Differentiation, 24, pp. 1473-1474. (doi: 10.1038/cdd.2017.97)

Anthony, N. G., Baiget, J., Berretta, G., Boyd, M., Breen, D., Edwards, J., Gamble, C., Gray, A. I., Harvey, A. L., Hatziieremia, S., Ho, K. H., Huggan, J. K., Lang, S., Llona-Minguez, S., Luo, J. L., McIntosh, K., Paul, A., Plevin, R. J., Robertson, M. N., Scott, R., Suckling, C. J., Sutcliffe, O. B., Young, L. C., Mackay, S. P. (2017) Inhibitory Kappa B kinse α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers. Journal of Medicinal Chemistry, 60, pp. 7043-7066. (doi: 10.1021/acs.jmedchem.7b00484)

Phillips, T. J. et al. (2017) Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development. Scientific Reports, 7, (doi: 10.1038/s41598-017-06300-1)

Carron, E. C., Homra, S., Rosenberg, J., Coffelt, S. B., Kittrell, F., Zhang, Y., Creighton, C. J., Fuqua, S. A., Medina, D., Machado, H. L. (2017) Macrophages promote the progression of premalignant mammary lesions to invasive cancer. Oncotarget, 8, pp. 50731-50746. (doi: 10.18632/oncotarget.14913)

Park, J. H., Roxburgh, C. S.D., Edwards, J., Horgan, P. G., McMillan, D. C. (2017) In reply to "Hynes S.O. et al. Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study" Histopathology, 71, pp. 326-327. (doi: 10.1111/his.13195)

Khandelwal, G., Girotti, M. R., Smowton, C., Taylor, S., Wirth, C., Dynowski, M., Frese, K. K., Brady, G., Dive, C., Marais, R., Miller, C. (2017) Next-generation sequencing analysis and algorithms for PDX and CDX models. Molecular Cancer Research, 15, pp. 1012-1016. (doi: 10.1158/1541-7786.MCR-16-0431)

Meyer, T., Fox, R., Ma, Y. T., Ross, P. J., James, M. W., Sturgess, R., Stubbs, C., Stocken, D. D., Wall, L., Watkinson, A., Hacking, N., Evans, T.R. J., Collins, P., Hubner, R. A., Cunningham, D., Primrose, J. N., Johnson, P. J., Palmer, D. H. (2017) Sorafenib in combination with transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma (TACE 2): a randomised placebo-controlled, double-blind, phase 3 trial. Lancet Gastroenterology and Hepatology, 2, pp. 565-575. (doi: 10.1016/S2468-1253(17)30156-5)

Mcsorley, S. T., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. C. (2017) The impact of preoperative dexamethasone on the magnitude of the postoperative systemic inflammatory response and complications following surgery for colorectal cancer. Annals of Surgical Oncology, 24, pp. 2104-2112. (doi: 10.1245/s10434-017-5817-3)

Dolan, R. D., McSorley, S. T., Horgan, P. G., Laird, B., McMillan, D. C. (2017) The role of the systemic inflammatory response in predicting outcomes in patients with advanced inoperable cancer: Systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 116, pp. 134-146. (doi: 10.1016/j.critrevonc.2017.06.002)

Harris, N.L.E., Vennin, C., Conway, J.R.W., Vine, K.L., Pinese, M., Cowley, M.J., Shearer, R.F., Lucas, M.C., Herrmann, D., Allam, A.H., Pajic, M., Morton, J., Biankin, A.V., Ranson, M., Timpson, P., Saunders, D.N. (2017) SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer. Oncogene, 36, pp. 4288-4298. (doi: 10.1038/onc.2017.63)

Brock, K., Billingham, L., Copland, M., Siddique, S., Sirovica, M., Yap, C. (2017) Implementing the EffTox dose-finding design in the Matchpoint trial. BMC Medical Research Methodology, 17, (doi: 10.1186/s12874-017-0381-x)

Kayhanian, H., Smyth, E. C., Braconi, C. (2017) Emerging molecular targets and therapy for cholangiocarcinoma. World Journal of Gastrointestinal Oncology, 9, pp. 268-280. (doi: 10.4251/wjgo.v9.i7.268)

Munkley, J., McClurg, U. L., Livermore, K. E., Ehrmann, I., Knight, B., Mccullagh, P., Mcgrath, J., Crundwell, M., Harries, L. W., Leung, H. Y., Mills, I. G., Robson, C. N., Rajan, P., Elliott, D. J. (2017) The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration. Scientific Reports, 7, (doi: 10.1038/s41598-017-05489-5)

Clark, R. E., Polydoros, F., Apperley, J. F., Milojkovic, D., Pocock, C., Smith, G., Byrne, J. L., de Lavallade, H., O'Brien, S. G., Coffey, T., Foroni, L., Copland, M. (2017) De-escalation of tyrosine kinase inhibitor dose in patients with chronic myeloid leukaemia with stable major molecular response (DESTINY): an interim analysis of a non-randomised, phase 2 trial. Lancet Haematology, 4, pp. e310-e316. (doi: 10.1016/S2352-3026(17)30066-2)

Rice, A.J., Cortes, E., Lachowski, D., Cheung, B.C.H., Karim, S.A., Morton, J.P., Del Rio Hernandez, A. (2017) Matrix stiffness induces epithelial-mesenchymal transition and promotes chemoresistance in pancreatic cancer cells. Oncogenesis, 6, (doi: 10.1038/oncsis.2017.54)

Rosenfeldt, M. T., O'Prey, J., Flossbach, L., Nixon, C., Morton, J. P., Sansom, O. J., Ryan, K. M. (2017) PTEN deficiency permits the formation of pancreatic cancer in the absence of autophagy. Cell Death and Differentiation, 24, pp. 1303-1304. (doi: 10.1038/cdd.2016.120)

de la Cruz-Merino, L., Di Guardo, L., Grob, J.-J., Venosa, A., Larkin, J., McArthur, G. A., Ribas, A., Acierto, P. A., Evans, J. T.R., Gomez‑Escobar, A., Barteselli, G., Eng, S., Hsu, J. J., Uyei, A., Dréno, B. (2017) Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF-mutated melanoma treated in the randomized coBRIM study. Journal of Translational Medicine, 15, (doi: 10.1186/s12967-017-1246-0)

Alderdice, M., Dunne, P. D., Cole, A. J., O’Reilly, P. G., McArt, D. G., Bingham, V., Fuchs, M.-A., McQuaid, S., Loughrey, M. B., Murray, G. I., Samuel, L. M., Lawler, M., Wilson, R. H., Salto-Tellez, M., Coyle, V. M. (2017) Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival. Modern Pathology, 30, pp. 1287-1298. (doi: 10.1038/modpathol.2017.47)

Kelly, A. U., McSorley, S. T., Patel, P., Talwar, D. (2017) Interpreting iron studies. British Medical Journal, 357, (doi: 10.1136/bmj.j2513)

Alvi, M. A., Loughrey, M. B., Dunne, P., McQuaid, S., Turkington, R., Fuchs, M.-A., McGready, C., Bingham, V., Pang, B., Moore, W., Maxwell, P., Lawler, M., James, J. A., Murray, G. I., Wilson, R. H., Salto-Tellez, M. (2017) Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies. British Journal of Cancer, 117, pp. 203-209. (doi: 10.1038/bjc.2017.168)

Blyth, K. G., Bellofiore, A., Jayasekera, G., Foster, J. E., Steedman, T., Chesler, N. C., Peacock, A. J. (2017) Dobutamine stress MRI in pulmonary hypertension: relationships between stress pulmonary artery relative area change, RV performance, and 10-year survival. Pulmonary Circulation, 7, pp. 465-475. (doi: 10.1177/2045893217704838)

Lote, H. et al. (2017) Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer. Annals of Oncology, 28, pp. 1243-1249. (doi: 10.1093/annonc/mdx074)

Roseweir, A. K., McMillan, D. C., Horgan, P. G., Edwards, J. (2017) Colorectal cancer subtypes: Translation to routine clinical pathology. Cancer Treatment Reviews, 57, pp. 1-7. (doi: 10.1016/j.ctrv.2017.04.006)

Loveridge, C. J., Mui, E. J., Patel, R., Tan, E. H., Ahmad, I., Welsh, M., Galbraith, J., Hedley, A., Nixon, C., Blyth, K., Sansom, O., Leung, H. Y. (2017) Increased T cell infiltration elicited by Erk5 deletion in a Pten-deficient mouse model of prostate carcinogenesis. Cancer Research, 77, pp. 3158-3168. (doi: 10.1158/0008-5472.CAN-16-2565)

Roseweir, A. K., McCall, P., Scott, A., Liew, B., Lim, Z., Mallon, E. A., Edwards, J. (2017) Phosphorylation of androgen receptors at serine 515 is a potential prognostic marker for triple negative breast cancer. Oncotarget, 8, pp. 37172-37185. (doi: 10.18632/oncotarget.16420)

Lachowski, D., Cortes, E., Pink, D., Chronopoulos, A., Karim, S. A., Morton, J. P., del Río Hernández, A. E. (2017) Substrate rigidity controls activation and durotaxis in pancreatic stellate cells. Scientific Reports, 7, (doi: 10.1038/s41598-017-02689-x)

Park, J.H., Van Wyk, H., Roxburgh, C.S.D., Horgan, P.G., Edwards, J., McMillan, D.C. (2017) Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer. British Journal of Cancer, 116, pp. 1444-1450. (doi: 10.1038/bjc.2017.108)

Bennett, L., Mallon, E. A., Horgan, P. G., Paul, A., McMillan, D. C., Edwards, J. (2017) The relationship between members of the canonical NF-KB pathway, components of tumour microenvironment and survival in patients with invasive ductal breast cancer. Oncotarget, 8, pp. 33002-33013. (doi: 10.18632/oncotarget.16031)

Hock, A. K., Cheung, E. C., Humpton, T. J., Monteverde, T., Paulus-Hock, V., Lee, P., McGhee, E., Scopelliti, A., Murphy, D. J., Strathdee, D., Blyth, K., Vousden, K. H. (2017) Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo. Scientific Reports, 7, (doi: 10.1038/s41598-017-01741-0)

Pepe, F., Pagotto, S., Soliman, S., Rossi, C., Lanuti, P., Braconi, C., Mariani-Costantini, R., Visone, R., Veronese, A. (2017) Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells. Oncogenesis, 6, (doi: 10.1038/oncsis.2017.35)

Carmody, R., Keeshan, K. (2017) The Tribble with APL: a new road to therapy. Cancer Cell, 31, pp. 612-613. (doi: 10.1016/j.ccell.2017.04.011)

Rewhorn, M.J., Baxter, G., Leung, H.Y. (2017) Delayed fistula post-salvage prostate cryotherapy. Journal of Clinical Urology, 10, pp. 189-190. (doi: 10.1177/2051415814565201)

Kerr, L., Leung, H. Y., Melquiot, N., Arestis, N., Sidek, N. (2017) Lymphoma masquerading as advanced prostate cancer with lymphadenopathy. Journal of Clinical Urology, 10, pp. 174-176. (doi: 10.1177/2051415814560081)

Dreyer, S. B., Powell, A. G.M.T., McSorley, S. T., Waterston, A., Going, J. J., Edwards, J., McMillan, D. C., Horgan, P. G. (2017) The pretreatment systemic inflammatory response is an important determinant of poor pathologic response for patients undergoing neoadjuvant therapy for rectal cancer. Annals of Surgical Oncology, 24, pp. 1295-1303. (doi: 10.1245/s10434-016-5684-3)

McSorley, S. T., Roxburgh, C. S., Horgan, P. G., McMillan, D. C. (2017) Re: Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial) British Medical Journal, 357,

Daniels, B. P., Snyder, A. G., Olsen, T. M., Orozco, S., Oguin III, T. H., Tait, S. W.G., Martinez, J., Gale, M., Loo, Y.-M., Oberst, A. (2017) RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation. Cell, 169, pp. 301-313.e11. (doi: 10.1016/j.cell.2017.03.011)

Vennin, C. et al. (2017) Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. Science Translational Medicine, 9, (doi: 10.1126/scitranslmed.aai8504)

Watt, D., Mcsorley, S. T., Park, J. H., Horgan, P. G., McMillan, D. C. (2017) A postoperative systemic inflammation score predicts short- and long-term outcomes in patients undergoing surgery for colorectal cancer. Annals of Surgical Oncology, 24, pp. 1100-1109. (doi: 10.1245/s10434-016-5659-4)

Ichim, G., Tait, S. W.G. (2017) Cancer therapy-induced PAFR ligand expression: any role for caspase activity? Nature Reviews Cancer, 17, pp. 253. (doi: 10.1038/nrc.2017.16)

Bennett, L., Quinn, J., McCall, P., Mallon, E. A., Horgan, P. G., McMillan, D. C., Paul, A., Edwards, J. (2017) High IKKα expression is associated with reduced time to recurrence and cancer specific survival in oestrogen receptor (ER)-positive breast cancer. International Journal of Cancer, 140, pp. 1633-1644. (doi: 10.1002/ijc.30578)

Dreyer, S. B., Chang, D. K., Bailey, P., Biankin, A. V. (2017) Pancreatic cancer genomes: implications for clinical management and therapeutic development. Clinical Cancer Research, 23, pp. 1638-1646. (doi: 10.1158/1078-0432.CCR-16-2411)

Forster, V. J., van Delft, F. W., Baird, S. F., Mair, S., Skinner, R., Halsey, C. (2017) Reply: Methotrexate neurotoxicity due to drug interactions: an inadequate folinic acid effect. Cancer Chemotherapy and Pharmacology, 79, pp. 841-842. (doi: 10.1007/s00280-017-3270-4)

Park, J. H., Van Wyk, H. C., McMillan, D. C., Quinn, J. A., Clark, J., Roxburgh, C., Horgan, P. G., Edwards, J. (2017) Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host. Clinical Cancer Research, 23, pp. 1698-1709. (doi: 10.1158/1078-0432.CCR-16-1416)

King, J., Palmer, D.H., Johnson, P., Ross, P., Hubner, R.A., Sumpter, K., Darby, S., Braconi, C., Iwuji, C., Swinson, D., Collins, P., Patel, K., Nobes, J., Muazzam, I., Blesing, C., Kirkwood, A., Nash, S., Meyer, T. (2017) Sorafenib for the treatment of advanced hepatocellular cancer – a UK audit. Clinical Oncology, 29, pp. 256-262. (doi: 10.1016/j.clon.2016.11.012)

Cheng, K. K.W., Dickson, A., Gujam, F. J.A., McMillan, D. C., Edwards, J. (2017) The relationship between oestrogen receptor-alpha phosphorylation and the tumour microenvironment in patients with primary operable ductal breast cancer. Histopathology, 70, pp. 782-797. (doi: 10.1111/his.13134)

Eyers, P. A., Keeshan, K., Kannan, N. (2017) Tribbles in the 21st Century: the evolving roles of Tribbles pseudokinases in biology and disease. Trends in Cell Biology, 27, pp. 284-298. (doi: 10.1016/j.tcb.2016.11.002)

Wilson, R. H., Evans, T.R. J., Middleton, M. R., Molife, L. R., Spicer, J., Dieras, V., Roxburgh, P., Giordano, H., Jaw-Tsai, S., Goble, S., Plummer, R. (2017) A phase I study of intravenous and oral rucaparib in combination with chemotherapy in patients with advanced solid tumours. British Journal of Cancer, 116, (doi: 10.1038/bjc.2017.36)

Ahmed, A., Wan, X., Mitxitorena, I., Lindsay, A. J., Pandolfi, P. P., McCaffrey, M. W., Keeshan, K., Chen, Y. H., Carmody, R. J. (2017) Regulation of NF-κB by PML and PML-RARα. Scientific Reports, 7, (doi: 10.1038/srep44539)

Gundry, C., Marco, S., Rainero, E., Miller, B., Dornier, E., Mitchell, L., Caswell, P. T., Campbell, A., Hogeweg, A., Sansom, O. J., Morton, J. P., Norman, J. C. (2017) Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nature Communications, 8, (doi: 10.1038/ncomms14646)

Woodham, E. F., Paul, N. R., Tyrrell, B., Spence, H. J., Swaminathan, K., Scribner, M. R., Giampazolias, E., Hedley, A., Clark, W., Kage, F., Marston, D. J., Hahn, K. M., Tait, S. W.G., Larue, L., Brakebusch, C. H., Insall, R. H., Machesky, L. M. (2017) Coordination by Cdc42 of actin, contractility, and adhesion for melanoblast movement in mouse skin. Current Biology, 27, pp. 624-637. (doi: 10.1016/j.cub.2017.01.033)

Gutierrez, K. D., Davis, M. A., Daniels, B. P., Olsen, T. M., Ralli-Jain, P., Tait, S. W.G., Gale, Jr., M., Oberst, A. (2017) MLKL activation triggers NLRP3-mediated processing and release of IL-1β independently of gasdermin-D. Journal of Immunology, 198, pp. 2156-2164. (doi: 10.4049/jimmunol.1601757)

Salvucci, M. et al. (2017) A stepwise integrated approach to personalized risk predictions in stage III colorectal cancer. Clinical Cancer Research, 23, pp. 1200-1212. (doi: 10.1158/1078-0432.CCR-16-1084)

Simon, H.-U., Friis, R., Tait, S. W.G., Ryan, K. M. (2017) Retrograde signaling from autophagy modulates stress responses. Science Signaling, 10, (doi: 10.1126/scisignal.aag2791)

Cousins, A. F., Olivares, O., Michie, A. M., Gottlieb, E., Halsey, C. (2017) Association of CNS Involvement in Childhood Acute Lymphoblastic Leukaemia with Cholesterol Biosynthesis Upregulation. (doi: 10.1016/S0140-6736(17)30431-2)

Hernandez-Fernaud, J. R. et al. (2017) Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nature Communications, 8, (doi: 10.1038/ncomms14206)

Dolan, R., McSorley, S. T., McMillan, D. C., Horgan, P. G. (2017) Association of Ongoing Systemic Inflammatory Response (SIR) at Diagnosis With Lymph Node Retrieval and Node Positivity in Patients Undergoing Surgery for Colonic Cancer. (doi: 10.1200/jco.2017.35.4_suppl.550)

Dolan, R., MacLeod, N. J., McSorley, S. T., Horgan, P. G., Laird, B., McMillan, D. C. (2017) Evaluation of Systemic Inflammation-based Prognostic Scores in Patients With Advanced Colorectal Cancer Receiving Palliative Pelvic Radiotherapy (RT) (doi: 10.1200/jco.2017.35.4_suppl.558)

Rath, N., Morton, J. P., Julian, L., Helbig, L., Kadir, S., McGhee, E. J., Anderson, K. I., Kalna, G., Mullin, M., Pinho, A. V., Rooman, I., Samuel, M. S., Olson, M. F. (2017) ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. EMBO Molecular Medicine, 9, pp. 198-218. (doi: 10.15252/emmm.201606743)

Smowton, C., Balla, A., Antoniades, D., Miller, C., Pallis, G., Dikaiakos, M. D., Xing, W. (2017) A cost-effective approach to improving performance of big genomic data analyses in clouds. Future Generation Computer Systems, 67, pp. 368-381. (doi: 10.1016/j.future.2015.11.011)

Mcsorley, S. T., Khor, B. Y., MacKJay, G. J., Horgan, P. G., McMillan, D. C. (2017) Examination of a CRP first approach for the detection of postoperative complications in patients undergoing surgery for colorectal cancer: a pragmatic study. Medicine, 96, (doi: 10.1097/MD.0000000000006133)

van Baal, J.O.A.M., Van de Vijver, K.K., Coffelt, S.B., van der Noort, V., van Driel, W.J., Kenter, G.G., Buist, M.R., Lok, C.A.R. (2017) Incidence of lymph node metastases in clinical early-stage mucinous and seromucinous ovarian carcinoma: a retrospective cohort study. BJOG: An International Journal of Obstetrics and Gynaecology, 124, pp. 486-494. (doi: 10.1111/1471-0528.14425)

Previdi, M. C., Carotenuto, P., Zito, D., Pandolfo, R., Braconi, C. (2017) Noncoding RNAs as novel biomarkers in pancreatic cancer: what do we know? Future Oncology, 13, pp. 443-453. (doi: 10.2217/fon-2016-0253)

Evans, T.R.J., Van Cutsem, E., Moore, M.J., Bazin, I.S., Rosemurgy, A., Bodoky, G., Deplanque, G., Harrison, M., Melichar, B., Pezet, D., Elekes, A., Rock, E., Lin, C., Strauss, L., O'Dwyer, P.J. (2017) Phase 2 placebo-controlled, double-blind trial of dasatinib added to gemcitabine for patients with locally-advanced pancreatic cancer. Annals of Oncology, 28, pp. 354-361. (doi: 10.1093/annonc/mdw607)

Spender, L. C., Inman, G. J. (2017) Targeting BRAF-mutant tumours with TGFBR1 inhibitors. Aging, 9, pp. 5-6. (doi: 10.18632/aging.101169)

Sarosiek, K. A., Fraser, C., Muthalagu, N., Bhola, P. D., Chang, W., McBrayer, S. K., Cantlon, A., Fisch, S., Golomb-Mello, G., Ryan, J. A., Deng, J., Jian, B., Corbett, C., Goldenberg, M., Madsen, J. R., Liao, R., Walsh, D., Sedivy, J., Murphy, D. J., Carrasco, D. R., Robinson, S., Moslehi, J., Letai, A. (2017) Developmental regulation of mitochondrial apoptosis by c-Myc governs age- and tissue-specific sensitivity to cancer therapeutics. Cancer Cell, 31, pp. 142-156. (doi: 10.1016/j.ccell.2016.11.011)

Diaz-Vera, J., Palmer, S., Hernandez-Fernaud, J. R., Dornier, E., Mitchell, L. E., MacPherson, I., Edwards, J., Zanivan, S., Norman, J. C. (2017) A proteomic approach to identify endosomal cargoes controlling cancer invasiveness. Journal of Cell Science, 130, pp. 697-711. (doi: 10.1242/jcs.190835)

Iltzsche, F., Simon, K., Stopp, S., Pattschull, G., Francke, S., Wolter, P., Hauser, S., Murphy, D.J., Garcia, P., Rosenwald, A., Gaubatz, S. (2017) An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. Oncogene, 36, pp. 110-121. (doi: 10.1038/onc.2016.181)

Oruganti, S.R., Torres, D.J., Krebsbach, S., Asperti-Boursin, F., Winters, J., Matlawska-Wasowska, K., Winter, S.S., Halsey, C., Cannon, J.L. (2017) CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS. Leukemia, 31, pp. 255-258. (doi: 10.1038/leu.2016.272)

Morton, J. P., Sansom, O. J. (2017) CXCR2 inhibition in pancreatic cancer: opportunities for immunotherapy? Immunotherapy, 9, pp. 9-12. (doi: 10.2217/imt-2016-0115)

Correia-Melo, C., Ichim, G., Tait, S., Passos, J. F. (2017) Depletion of mitochondria in mammalian cells through enforced mitophagy. Nature Protocols, 12, pp. 183-194. (doi: 10.1038/nprot.2016.159)

Humphris, J. L. et al. (2017) Hypermutation in pancreatic cancer. Gastroenterology, 152, pp. 68-74.e2. (doi: 10.1053/j.gastro.2016.09.060)

Tsim, S., Stobo, D. B., Alexander, L., Kelly, C., Blyth, K. G. (2017) The diagnostic performance of routinely acquired and reported computed tomography imaging in patients presenting with suspected pleural malignancy. Lung Cancer, 103, pp. 38-43. (doi: 10.1016/j.lungcan.2016.11.010)

Khor, B. Y., McSorley, S. T., Horgan, P. G., McMillan, D. C. (2017) The relationship between systemic inflammation and stoma formation following anterior resection for rectal cancer: a cross-sectional study. International Journal of Surgery, 37, pp. 79-84. (doi: 10.1016/j.ijsu.2016.12.010)

Ritschka, B., Storer, M., Mas, A., Heinzmann, F., Ortells, M. C., Morton, J. P., Sansom, O. J., Zender, L., Keyes, W. M. (2017) The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration. Genes and Development, 31, pp. 172-183. (doi: 10.1101/gad.290635.116)

Horne, G. A., Copland, M. (2017) Approaches for targeting self-renewal pathways in cancer stem cells: implications for hematological treatments. Expert Opinion on Drug Discovery, 12, pp. 465-474. (doi: 10.1080/17460441.2017.1303477)

Dolan, R., McLeod, N., McSorley, S., McMillan, D., Horgan, P. (2017) Evaluation of Systemic Inflammation Based Prognostic Scoresin Patients with Advanced Rectal Cancer Receiving Palliative Pelvicradiotherapy.

McSorley, S. T., Dolan, R. D., Roxburgh, C. S.D., McMillan, D. C., Horgan, P. G. (2017) How and why systemic inflammation worsens quality of life in patients with advanced cancer. Expert Review of Quality of Life in Cancer Care, 2, pp. 167-175. (doi: 10.1080/23809000.2017.1331705)

Rose, A. M., Sansom, O. J., Inman, G. J. (2017) Loss of TGF-β signaling drives cSCC from skin stem cells – More evidence. Cell Cycle, 16, pp. 386-387. (doi: 10.1080/15384101.2016.1259892)

Kersten, K., Coffelt, S. B., Hoogstraat, M., Verstegen, N. J.M., Vrijland, K., Ciampricotti, M., Doornebal, C. W., Hau, C.-S., Wellenstein, M. D., Salvagno, C., Doshi, P., Lips, E. H., Wessels, L. F.A., de Visser, K. E. (2017) Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages. OncoImmunology, 6, (doi: 10.1080/2162402X.2017.1334744)

Carter, L., Rothwell, D. G., Mesquita, B., Smowton, C., Leong, H. S., Fernandez-Gutierrez, F., Li, Y., Burt, D. J., Antonello, J., Morrow, C. J., Hodgkinson, C. L., Morris, K., Priest, L., Carter, M., Miller, C., Hughes, A., Blackhall, F., Dive, C., Brady, G. (2017) Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer. Nature Medicine, 23, pp. 114-119. (doi: 10.1038/nm.4239)

Draper, J. E., Sroczynska, P., Leong, H. S., Fadlullah, M. Z. H., Miller, C., Kouskoff, V., Lacaud, G. (2017) Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors. Blood, 130, pp. 271-284. (doi: 10.1182/blood-2016-06-723635)

Dolan, R., McSorley, S., McMillan, D., Horgan, P. (2017) Ongoing Systemic Inflammatory Response at Diagnosis is Notassociated with Lower Lymph Node Retrieval and Higher Node Positivityin Patients Undergoing Surgery for Colonic Cancer.

Weigert, M., Binks, A., Dowson, S., Leung, E. Y.L., Athineos, D., Yu, X., Mullin, M., Walton, J. B., Orange, C., Ennis, D., Blyth, K., Tait, S. W.G., McNeish, I. A. (2017) RIPK3 promotes adenovirus type 5 activity. Cell Death and Disease, 8, (doi: 10.1038/s41419-017-0110-8)

Horne, G., Jackson, L., Helgason, V., Holyoake, T. L. (2017) Stem cell guardians – old and new perspectives in LSC biology. Current Drug Targets, 18, pp. 405-413. (doi: 10.2174/1389450117666160712092944)