O'nyong-nyong virus (ONNV) is ONNV is the only known arbovirus to be transmitted by Anopheles mosquitoes, such as the African malaria vector An. gambiae. Most other mosquito-transmitted arboviruses are spread by aedine species including Aedes aegypti and Ae. albopictus, as well as culicine and otherspecies. ONNV is an alphavirus from the Togaviridae family and is closely related to chikungunya virus – though, it has a more restricted geographical range, limited to the African continent. Human infections result in fever, joint pains, rashes and headaches and ONNV has been identified as the causative agent of large epidemics in E Africa.
Previous research at the CVR has investigated the interactions between ONNV and the antiviral immune pathways of An. gambiae.
Contact: Alain Kohl