Research

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Rulach, R., Harrow, S., Chalmers, A. J., Fenwick, J. (2026) Cumulative oesophageal dose and risk of high-grade toxicity in thoracic re-irradiation: a dose/toxicity analysis. Clinical and Translational Radiation Oncology, 57, (doi: 10.1016/j.ctro.2026.101108)

Williams, H. L., Poulain, N., Powley, I., Martinelli, S., Bielik, R., Leslie, H., Nixon, C., Wilson, C. R., Sereno, M., He, Z., Offier-Jones, L., Ballantyne, F., Pennie, R., Wood, C. S., Lewis, D. Y., Jamieson, N. B., Le Quesne, J. (2026) Spatial molecular plasticity underpins lethal morphologies in lung adenocarcinoma. Modern Pathology, 39, (doi: 10.1016/j.modpat.2026.100960)

Binner, P., Radford, J., Starshynov, I., Madhusudan, M., Strathdee, K., Stevenson, K., Walker, M., Ciccone, G., Tejeda, G., Tobin, A. B., Vassalli, M., Chalmers, A. J., Ekanayake, J., Faccio, D. (2026) Wide-field and non-invasive imaging of brain tumours with scattered light techniques. Biomedical Optics Express, 17, pp. 1112-1124. (doi: 10.1364/BOE.587407)

Himonas, E., de Beauchamp, L., Zerbst, D., Desmares-Romain, E., Sarnello, D., Kalkman, E., Rattigan, K., James, D., Shokry, E., Copland, M., Griessinger, E., Récher, C., de Mas, V., Vergez, F., Sumpton, D., Schimmer, A., Minden, M., Gottlieb, E., Shanks, E., Sarry, J.-E., Helgason, V. (2026) A metabolism-specific drug-repurposing screen reveals itraconazole as a potent OXPHOS inhibitor in acute myeloid leukemia. Blood, (doi: 10.1182/blood.2024027853)

White, M. et al. (2026) MAPK-driven epithelial cell plasticity drives colorectal cancer therapeutic resistance. Nature, 650, pp. 748-758. (doi: 10.1038/s41586-025-09916-w)

Vallatos, A., Al-Mubarak, H. F. I., Birch, J. L., Icer, Y., McBain, C., Coope, D. J., Karabatsou, K., Mills, S. J., Parker, G. J. M., Holmes, W. M., Chalmers, A. J., Jackson, A., Waldman, A., Thompson, G. (2026) Marginal diffusion slope as a prognostic imaging biomarker of infiltrating phenotype in glioblastoma; a cancer imaging biomarker roadmap study. Neuro-Oncology Advances, (doi: 10.1093/noajnl/vdag028)

Bryce, A. S., Martinelli, S., Schubert Santana, L., Officer-Jones, L., Baird, R. L., Ballantyne, F., Rakovic, K., Powley, I. R., Tataran, D., Meltzer, D. J., Walsh, C., Duthie, F., Farndale, L., Claudio Quiros, A., Yuan, K., Le Quesne, J., Froeling, F. E.M., Dreyer, S. B., Chang, D. K. (2026) Morphospatial profiling of cancer-associated fibroblasts reveals architectural subtypes of pancreatic ductal adenocarcinoma. bioRxiv, (doi: 10.64898/2026.02.06.704414)

Monaghan, L., Bunschoten, R. P., Bittencourt-Silvestre, J., Park, T., Gannon, S., Pirvan, P.-A., Hoose, A., Wheadon, H., Liskamp, R. M.J., Huang, X., Jorgensen, H. G. (2026) Selective small molecule targeting of KDM4 as a therapeutic strategy to reduce proliferation of acute myeloid leukemia. British Journal of Haematology, (doi: 10.1111/bjh.70351)

Nailon, W. H. et al. (2026) Protocol for the PROSECCA study: a new approach for predicting radiotherapy outcome using artificial intelligence and electronic population-based healthcare data. BMJ Open, 16, (doi: 10.1136/bmjopen-2025-104408)

Patterson, S.D., Gottschalk, A., Hayden, C., Young, R., Hair, A., Jørgensen, H.G., Wheadon, H.W., Apperley, J.F., Glauche, I., Clark, R.E., Copland, M., Roeder, I. (2026) Sequential BCR::ABL1 evaluation during dose de-escalation in peripheral blood is more predictive of TFR success than single assessment at dose de-escalation in either peripheral blood or bone marrow. Leukemia, 40, pp. 459-463. (doi: 10.1038/s41375-025-02853-7)

Centeno, P. P., Chester, C., Kanellos, G., Ford, C. A., Cammarezi, P., Inman, G. J., Jamieson, T., Ridgeway, R. A., Marais, R., Campbell, A. D., Sansom, O. J. (2026) SOX2 confers tumour permissiveness in a specific skin progenitor population. Nature Communications, 17, (doi: 10.1038/s41467-025-66251-4)

Ren, H., Elliott, N., Lye, B., Sharif Shohan, M. U., Cross, J. W., Field, L., Ponnusamy, K., Rice, S., Jackson, T., Ilia, L., El Ouazzani, N., Thomas, R., Inglott, S., Bartram, J., Smith, O., Bond, J., Roberts, I. A. G., Halsey, C., Bashford-Rogers, R., Milne, T. A., Roy, A., Karadimitris, A. (2026) 'Off-the-shelf' dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal KMT2A-rearranged leukemia. Blood, 147, pp. 180-196. (doi: 10.1182/blood.2025029302)

Keeshan, K. (2026) Fetal defense against leukemia: a developmental shield. Blood, 147, pp. 7-8. (doi: 10.1182/blood.2025031544)

Smith, C. D.L., McMahon, A. D., Inman, G. J., Conway, D. I., Douglas, C. M., Paterson, C. (2026) The COVID-19 pandemic has not influenced survival outcomes of head and neck cancer squamous cell carcinomas in the West of Scotland: a retrospective cohort study. BJC Reports, 4, (doi: 10.1038/s44276-026-00203-3)

Kanellos, G. et al. (2025) Nucleophosmin supports WNT-driven hyperproliferation and tumour initiation. Nature Genetics, (doi: 10.1038/s41588-025-02408-7)

Gajic, N., Christie, R., Martin, J., Josephs-Spaulding, J., Lam, S., Ackermann, T., Dunn, K., Shokry, E., Huerta Uribe, A., Irving, J., van Delft, F., de Muyer, F., Ntziachristos, P., Vande Voorde, J., Sumpton, D., Tardito, S., Brown, A., Tait, S., Halsey, C. (2025) NADPH Controls a Cell State Vulnerability Towards Ferroptosis in Acute Lymphoblastic Leukaemia. (doi: 10.1182/blood-2025-144)

Gajic, N., Christie, R., Lam, S., Ackermann, T., Himonas, E., Josephs-Spaulding, J., Manoharan, A., Assmann, V., Martin, J., Collings, A., Dunn, K., Shokry, E., Huerta Uribe, A., Burns, S., O'Connor, D., Mansour, M., Sumpton, D., Helgason, G. V., Vande Voorde, J., Tardito, S., Tait, S., Halsey, C. (2025) Selenocysteine Dependency Renders Central Nervous System Leukaemia Therapeutically Sensitive to Ferroptosi. (doi: 10.1182/blood-2025-1526)

Duguid, A., Malouf, C., Nitsche, L., Halsey, C., Ottersbach, K. (2025) Mixed-lineage leukaemia cells undergo unique adaptations in the CNS niche. Experimental Hematology, (doi: 10.1016/j.exphem.2025.105347)

Mikkelsen, T., Helenius, M., Ampatzidou, M., Attarbaschi, A., Andres-Jensen, L., Borkhardt, A., Cuevas, N., Escherich, G., Hagleitner, M., Halsey, C., Josephs-Spaulding, J., Lundgren, L., Pehn, S., Polychronopoulou, S., Stoltze, U., Toksvang, L., Wahlberg, A., Junk, S., Schmiegelow, K. (2025) Role of common host genome variants in Childhood Acute Lymphoblastic Leukemia. Leukemia, (doi: 10.1038/s41375-025-02804-2)

Glover, H. L., Tait, S. W.G. (2025) A fat-fueled fatality. Nature Chemical Biology, 21, pp. 1833-1834. (doi: 10.1038/s41589-025-01932-1)

Ponce-Garcia, F. M., Jenkins, Y. R., Assmann, V. D., Paul, S., Sharma, N. D., Moore, C., Ma, E. H., Diamanti, P., Hennequart, M., Blagih, J., Le, L., Jenkins, B. J., Rouvray, S., Cronin, J. G., Jones, R. G., Mansour, M., Blair, A., Halsey, C., Matlawska-Wasowska, K., Herranz, D., Vincent, E. E., Jones, N. (2025) Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia. Molecular Metabolism, 102, (doi: 10.1016/j.molmet.2025.102275)

Harryvan, T. J., Abudukelimu, S., Stouten, I., van der Wel, E. J., Janson, S. G.T., Lenos, K. J., Lannagan, T. R.M., White, M., Sansom, O. J., Verdegaal, E. M.E., Hawinkels, L. J.A.C. (2025) TGFβ signaling in cancer-associated fibroblasts drives a hepatic gp130-dependent pro-metastatic inflammatory program in colorectal cancer. iScience, 28, (doi: 10.1016/j.isci.2025.113696)

Raven, A. et al. (2025) Hepatic zonation determines tumorigenic potential of mutant β-catenin. Nature, (doi: 10.1038/s41586-025-09733-1)

Malik, A. K., Geh, D., Evans, T. R. J., Chow, P. K.H., Mann, D. A., White, S. A. (2025) Improving surgical treatments for hepatocellular carcinoma. Nature Reviews Gastroenterology and Hepatology, (doi: 10.1038/s41575-025-01143-y)

Bilsland, A. E., Degerman, S., Landfors, M., Wadsley, J., Wall, L., Thompson, C., Damyanova, I., Samuel, L., Petty, R., Jain, A., Lewsley, L.-A., MacMillan, A., MacLeod, M., Walker, J., McCormick, C., McCartney, E., Roxburgh, P., Stobo, J., Thomson, F., Evans, T.R. J., Keith, W. N. (2025) Relative telomere length and senescence-associated inflammatory cytokines as blood-based prognostic markers in patients with advanced or resectable gastro-oesophageal adenocarcinoma. British Journal of Cancer, (doi: 10.1038/s41416-025-03221-z)

Roche, J. J., Seyedshahi, F., Rakovic, K., Thu, A. W., Le Quesne, J., Blyth, K. G. (2025) Current and future applications of artificial intelligence in lung cancer and mesothelioma. Thorax, 80, pp. 957-965. (doi: 10.1136/thorax-2024-222054)

Dias, M. M., King, M. S., Shokry, E., Lilla, S., Paul, N., Thomason, P., Zanivan, S., Sumpton, D., Kunji, E. R. S., MacVicar, T. (2025) SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis. Molecular Cell, 85, pp. 4093-4104.e8. (doi: 10.1016/j.molcel.2025.08.018)

Bubnova, X., Wheadon, H., Hope, L. (2025) Evaluation of current mouse in vivo models and advanced in vitro models for leukaemia research. Blood Reviews, 74, (doi: 10.1016/j.blre.2025.101318)

Rulach, R., Harrow, S., Chalmers, A. J., Fenwick, J. (2025) Re-irradiation of recurrent lung tumours: associations between dose and 2-year survival. Clinical and Translational Radiation Oncology, 55, (doi: 10.1016/j.ctro.2025.101036)

Duncan, S., Kidd, A. C., Perdomo Lampignano, J., Cannon, P., Hall, M., Stobo, D. B., Maclay, J. D., Blyth, K. G., Lowe, D. J. (2025) Reference standard methodology in the clinical evaluation of AI chest X-ray algorithms for lung cancer detection: A systematic review. European Journal of Radiology, 192, (doi: 10.1016/j.ejrad.2025.112409)

Amaral, P., Christie, R., Gresham, D. O.F., Lucas, E. J.M., Xu, L. K., Behrmann, L., Bond, J., Degerman, S., van Delft, F. W., Goossens, S., Hagleitner, M., Halsey, C., Jones, N., Lammens, T., van Leeuwen, F. N., Mansour, M. R., Ntziachristos, P., O’Connor, D., Barata, J. T. (2025) Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia. Leukemia, 39, pp. 2575-2589. (doi: 10.1038/s41375-025-02723-2)

Galloway, A., Knop, K., Gomez-Moreira, C., Xavier, V., Thomson, S., Yoshikawa, H., Suska, O., Lukoszek, R., Kaskar, A., Lamond, A. I., MacVicar, T., Cowling, V. H. (2025) CMTR1 directs mitochondrial dynamics during T cell activation through epitranscriptomic regulation of splice isoforms. Cell Reports, 44, (doi: 10.1016/j.celrep.2025.116412)

Sharma, N. D., Keewan, E.’a., Ornatowski, W., Paul, S., Nysus, M., Barnett, C. C., Wolfson, J., Jacquez, Q., Myers, B. L., Kang, H., Zychowski, K. E., Winter, S. S., Loh, M. L., Hunger, S. P., Castillo, E. F., Taghon, T., Halsey, C., Vue, T. Y., Jones, N., Ntziachristos, P., Ksenia, M.-W. (2025) T-cell acute lymphoblastic leukemia exploits a neural proinflammatory pathway to colonize the meninges. Journal of Clinical Investigation, (doi: 10.1172/JCI188888)

Bone, M., Inman, G. J. (2025) Alternative transcription increases isoform complexity in Long Non-Coding RNAs and alters their functions in cancer. Non-coding RNA Research, 14, pp. 38-50. (doi: 10.1016/j.ncrna.2025.04.008)

Salvador-Barbero, B., Alatsatianos, M., Morton, J. P., Sansom, O. J., Hogan, C. (2025) KRASG12D cells override homeostatic cell elimination mechanisms in adult pancreas via Wnt5a and cell dormancy. Gastroenterology, 169, pp. 983-999.e21. (doi: 10.1053/j.gastro.2025.02.042)

Nakasone, M., Buetow, L., Gabrielsen, M., Ahmed, S. F., Majorek, K. A., Sibbet, G. J., Smith, B. O., Huang, D. T. (2025) Tuning ubiquitin transfer by RING E3 ubiquitin ligases through the linchpin residue. Life Science Alliance, 8, (doi: 10.26508/lsa.202503394)

Ahmed Hassan Elshiekh, A., Tait, S. W.G. (2025) Molecular cell biology of apoptosis in health and disease. Springer Nature

Cong, B., Thakur, T., Huerta Uribe, A., Stamou, E., Gopinath, S., Sansom, O., Maddocks, O., Cagan, R. (2025) Colon cancer cells evade drug action by enhancing drug metabolism. Oncogene, 44, pp. 3284-3296. (doi: 10.1038/s41388-025-03472-3)

Cooke, S. F., Wright, T. A., Lappin, G., Kyurkchieva, E., Sin, Y. Y., Ling, J., Zorn, A., O'Gorman, B., Banyard, W., Chang, C.-J., Wheadon, H., Huang, D. T., Baillie, G. S., Blair, C. M. (2025) Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells. Molecular Therapy Oncology, 33, (doi: 10.1016/j.omton.2025.201029)

Mills, J. G., Hepburn, L. A., Cowling, V. H. (2025) RNMT-dependent RNA cap methylation in health and disease. Biochemical Journal, 482, (doi: 10.1042/BCJ20253170)

Dobbin, S. J. H., Mangion, K., Berry, C., Roditi, G., Basak, S., McClure, J. D., Brooksbank, K., Sonecki, P., Sourbron, S., Evans, J., White, J., Welsh, P., Butler, E., Venugopal, B., Touyz, R. M., Jones, R. J., Petrie, M. C., Lang, N. N. (2025) Vascular endothelial growth factor inhibitor-induced cardiotoxicity: prospective multimodality assessment incorporating cardiovascular magnetic resonance imaging. Heart, 111, pp. 925-932. (doi: 10.1136/heartjnl-2024-325535)

Sofianidi, A. A., Syrigos, N. K., Blyth, K. G., Charpidou, A., Vathiotis, I. A. (2025) Breaking through: immunotherapy innovations in pleural mesothelioma. Clinical Lung Cancer, 26, pp. 458-469. (doi: 10.1016/j.cllc.2025.04.008)

Bone, M., Schreyer, D., Treanor-Taylor, M., Proby, C., Harwood, C., Leigh, I. M., Bailey, P., Inman, G. (2025) The landscape of long noncoding RNA during cutaneous squamous cell carcinoma progression. British Journal of Dermatology, 193, pp. 490-501. (doi: 10.1093/bjd/ljaf108)

Whyte, D. et al. (2025) Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes. EMBO Reports, 26, pp. 4248-4282. (doi: 10.1038/s44319-025-00520-7)

Cammareri, P. et al. (2025) Loss of colonic fidelity enables multilineage plasticity and metastasis. Nature, 644, pp. 547-556. (doi: 10.1038/s41586-025-09125-5)

Ahmed, S. F., Anand, J., Zhang, W., Buetow, L., Rishi, L., Mitchell, L., Bohlen, J., Lilla, S., Sibbet, G. J., Nixon, C., Patel, A., Majorek, K. A., Zanivan, S., Bustamante, J. C., Sidhu, S. S., Blyth, K., Huang, D. T. (2025) Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia. Molecular Therapy, pp. 3624-3643. (doi: 10.1016/j.ymthe.2025.04.042)

Tate, M. et al. (2025) Clinical effectiveness, safety and viral mutagenicity of oral favipiravir for COVID-19: results from a community-based, open-label, randomised, phase III trial. Antimicrobial Agents and Chemotherapy, 69, (doi: 10.1128/aac.00054-25)

MacVicar, T. (2025) High tide or low tide: the transport and metabolism of mitochondrial nucleotides. Biochemical Journal, 482, pp. 1105-1122. (doi: 10.1042/BCJ20253237)

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Huang, D., Dearlove, E. (2025) Insights into non-proteinaceous ubiquitination. Biochemical Society Transactions, 53, pp. 399-407. (doi: 10.1042/BST20253029)

Hurley, R., Osbourne, J., Inman, G. J., Conway, D. I., Paterson, C., Douglas, C. (2025) Pre-treatment serum prognostic scores and survival in curatively treated laryngeal cancer. Laryngoscope Investigative Otolaryngology, 10, (doi: 10.1002/lio2.70124)

Omar, R., Lee, M. A.W., Gonzalez-Trueba, L., Thomson, C. R., Hansen, U., Lianos, S., Hazarika, S., El Abdallah, O., Ammar, M. A., Cassels, J., Michie, A. M., Bulleid, N. J., Malfait, F., Van Agtmael, T. (2025) The chemical chaperone 4-phenylbutyric acid rescues molecular cell defects of COL3A1 mutations that cause vascular Ehlers Danlos Syndrome. Cell Death Discovery, 11, (doi: 10.1038/s41420-025-02476-y)

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Müller, M. et al. (2025) Human-correlated genetic models identify precision therapy for liver cancer. Nature, 639, pp. 754-764. (doi: 10.1038/s41586-025-08585-z)

Morgan, D. C., McDougall, L., Knuhtsen, A., Buetow, L., Steven, C. F., Shepperson, O., Huang, D. T., Hulme, A. N., Jamieson, A. G. (2025) Raman active diyne-Girder conformationally constrained p53 stapled peptides bind to MDM2 for visualisation without fluorophores. RSC Chemical Biology, 6, pp. 394-403. (doi: 10.1039/D4CB00288A)

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