How metabolic changes during aging alter Toxoplasma infection
Supervisors:
Dr Clare Harding, University of Glasgow
Dr Nicholas JW Rattray, University of Strathclyde
Summary:
This PhD project offers a rare chance to shape a new frontier in ageing and infectious disease research by exploring how ageing-related changes in host cell metabolism influence infection outcomes using Toxoplasma gondii, a globally prevalent intracellular parasite. Ageing is known to impair immune responses, but its impact on cellular nutrient handling and pathogen replication remains poorly understood. This project will investigate how senescent cells—characterised by altered iron accumulation and metabolic shifts—affect parasite growth, stage conversion, and host-pathogen interactions.
The student will employ cutting-edge techniques including global metabolomics, fluorescent metal reporters, ICP-MS, and X-ray fluorescence microscopy. They will work with multiple models of cellular senescence and genetically modified parasites to dissect the metabolic dependencies of infection. This interdisciplinary approach spans cell biology, immunology, parasitology, and ageing research.
Training outcomes include advanced lab skills, data analysis, and scientific communication, with opportunities to present at international conferences and contribute to high-impact publications. The student will gain experience in experimental design, host-pathogen modelling, and collaborative research with facilities such as the European Synchrotron.
Graduates will be equipped with a unique blend of expertise in infection biology and host metabolism, positioning them for careers in biomedical research, global health, or biotech innovation.