Dissecting the GIGYF1/2 Translational Repression Pathway to Unlock Antiviral Immune Response
Supervisors:
Dr Alfredo Castello, University of Glasgow
Dr Seyed Mehdi Jafarnejad, Queens University Belfast
Summary:
This collaborative project between the Castello lab (Glasgow) and the Jafarnejad lab (Belfast) will investigate a fundamental mechanism that regulates how cells control protein production (mRNA translation) in response to viral infections. Specifically, the project will focus on how the protein complexes formed by the GIGYF1 and GIGYF2 proteins helps fine-tune the innate immune response during RNA virus infections. The student will examine how different parts of this regulatory system work together (or independently) to control the production of immune signals like cytokines, and how viruses may disrupt this balance to their advantage.
Throughout the project, the student will gain hands-on experience in a wide range of experimental and analytical techniques, including molecular biology, virology, immunology, gene editing (CRISPR), and high-throughput approaches to study mRNA translation (Ribo-Seq), RNA-protein and protein-protein interactions. They will also develop essential bioinformatics skills to analyse and interpret complex biological data. This comprehensive training will prepare the student for future careers in academic research, biotechnology, or public health. Importantly, the project offers the chance to work at the interface of multiple disciplines to address questions with direct relevance to human health.