This course will explore current research on the challenges to the understanding of the physiology and pathophysiology of human heart and vasculature. The material centred on cardiac function discusses the latest theories on inotropic and electrical dysfunction associated in atrial and ventricular tissue. Presentations on vascular function synthesises the recent literature on endothelial control of vascular tone and the new data on changes associated with hypertension and arteriosclerosis. Translation of research to the clinic is covered by lectures on arrythmias, systemic hypertension and the potential for gene therapy for treatment.

This option is assigned to block S2-A. There is normally one 3-hour session on Mondays. 

None.

The course will be assessed by a 2-hour examination (75%) and in-course assessment consisting of a written assignment (25%).

The course aims to cover a broad range of cardiovascular science, from the cellular basis for the heart beat to the role of neurotransmitters in the control of blood pressure.

By the end of this course, students will be able to: 

■ Appraise the current theories for contractile and electrical function in cardiac muscle;

■ Appraise the current theories for vasomotor function in blood vessels;

■ Compare the cellular and molecular changes that occur in the cardiovascular system in response to different physiological or pathological stress stimuli;

■ Discuss problems with the theories and identify areas where we lack a specific understanding of the observed events;

■ Consider a reductionist approach and the rationale for the use of model organisms in cardiovascular studies.