This course will examine how the genetic contribution to complex phenotypes works, using examples from humans and from other organisms (e.g., fish, mammals). The course will cover the genetic basis for complex traits and disorders, the analysis of genetic influences at the genomic level, the analysis of complex qualitative and quantitative phenotypes through their genetics, and approaches used to identify and characterise variants with causal predisposing roles.

This option is assigned to block S2-C. There are normally 2-4 hours of teaching on Thursdays 

None

The course will be assessed by a 2-hour examination (70%) and an in-course assessment (30%), both of which will comprise a mixture of problem questions and mini-essay questions. The in-course assessment will be delivered either as a take-home assessment or as a timed test with preparation allowed beforehand.

The aims of this course are to foster:

■ understanding of the principles underlying human and non-human complex trait genetics and their application in modern approaches to studying such genetic disorders and traits;

■ awareness of the impact of complex genetics on the lives of individuals of any diploid species.

By the end of this course students will be able to:

■ Discuss and critically appraise the current state of understanding of relevant topics in the field of complex genetics, with specific focus on:

■ Patterns and properties of genomic variation and how it relates to the genetic contribution to a range of complex traits and disorders;

■ Identification and characterisation of genes and variants with a role in predisposition to complex phenotypes, including the basis for genome-wide analysis approaches;

■ Data interpretation;

■ Use the scientific literature to evaluate evidence supporting hypotheses in the field of complex genetics;

■ Critically discuss, evaluate and analyse data including that of a numerical and statistical nature.