Dr Leandro Lemgruber Soares

College Research Facility – Cellular Analysis Lead (MVLS Research Facilities)

telephone: 0141 330 4010
email: Leandro.LemgruberSoares@glasgow.ac.uk

120 University Place, Sir Graeme Davis Building - room L113, Glasgow, United Kingdom, G12 8TA G12 8TA

Publications

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Number of items: 61.

2024

Ovciarikova, J. et al. (2024) Two ancient membrane pores mediate mitochondrial-nucleus membrane contact sites. Journal of Cell Biology, 223(4), e202304075. (doi: 10.1083/jcb.202304075) (PMID:38456969)

Klinger, C. M., Jimenez-Ruiz, E., Mourier, T., Klingl, A., Lemgruber, L. , Pain, A., Dacks, J. B. and Meissner, M. (2024) Evolutionary analysis identifies a Golgi pathway and correlates lineage-specific factors with endomembrane organelle emergence in apicomplexans. Cell Reports, 43(2), 113740. (doi: 10.1016/j.celrep.2024.113740) (PMID:38363682)

Derby, S. et al. (2024) Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis. Neuro-Oncology, (doi: 10.1093/neuonc/noad210) (PMID:37936324) (Early Online Publication)

2023

Girasol, M. J. et al. (2023) RAD51-mediated R-loop formation acts to repair transcription associated DNA breaks driving antigenic variation in Trypanosoma brucei. Proceedings of the National Academy of Sciences of the United States of America, 120(48), e230930612. (doi: 10.1073/pnas.2309306120) (PMID:37988471) (PMCID:PMC10691351)

Girasol, M. J., Briggs, E., Marques, C. A. , Batista, J. M., Beraldi, D., Buchmore, R., Lemgruber, L. and McCulloch, R. (2023) Immunoprecipitation of RNA-DNA hybrid interacting proteins in Trypanosoma brucei reveals conserved and novel activities, including in the control of surface antigen expression needed for immune evasion by antigenic variation. Nucleic Acids Research, 51(20), pp. 11123-11141. (doi: 10.1093/nar/gkad836) (PMID:37843098) (PMCID:PMC10639054)

Black, J. A., Klinger, C. M., Lemgruber, L. , Dacks, J. B., Mottram, J. C. and McCulloch, R. (2023) AAK1-like: a putative pseudokinase with potential roles in cargo uptake in bloodstream form Trypanosoma brucei parasites. Journal of Eukaryotic Microbiology, 70(6), e12994. (doi: 10.1111/jeu.12994) (PMID:37548427)

Donnelly, H., Kurjan, A., Yong, L. Y., Xiao, Y., Lemgruber, L. , West, C., Salmeron-Sanchez, M. and Dalby, M. J. (2023) Fibronectin matrix assembly and TGFβ1 presentation for chondrogenesis of patient derived pericytes for microtia repair. Biomaterials Advances, 148, 213370. (doi: 10.1016/j.bioadv.2023.213370) (PMID:36931082)

2022

Xiao, Y., Donnelly, H., Sprott, M. , Luo, J., Jayawarna, V., Lemgruber, L. , Tsimbouri, P. M. , Meek, R.M. D., Salmeron-Sanchez, M. and Dalby, M. J. (2022) Material-driven fibronectin and vitronectin assembly enhances BMP-2 presentation and osteogenesis. Materials Today Bio, 16, 100367. (doi: 10.1016/j.mtbio.2022.100367) (PMID:35937570) (PMCID:PMC9352550)

Baldacchino, K. et al. (2022) Myelinated axons are the primary target of hemin-mediated oxidative damage in a model of the central nervous system. Experimental Neurology, 354, 114113. (doi: 10.1016/j.expneurol.2022.114113) (PMID:35569511)

2021

Rabas, N. et al. (2021) PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness. Journal of Cell Biology, 220(12), e202006049. (doi: 10.1083/jcb.202006049) (PMID:34623384) (PMCID:PMC8641410)

Edgar, J. M. , McGowan, E., Chapple, K., Möbius, W., Lemgruber, L. , Insall, R. H. , Nave, K.-A. and Boullerne, A. (2021) Rio-Hortega's drawings revisited with fluorescent proteins define a cytoplasm filled channel system of CNS myelin. Journal of Anatomy, 239(6), pp. 1241-1255. (doi: 10.1111/joa.13577)

Burley, G., Watson, A. J. B., de Koning, H. , Jones, K., Robertson, J., Bode, B., McWhinnie, F., Ungogo, M., Aldfer, M. and Lemgruber Soares, L. (2021) Direct, late‐stage mono‐N‐arylation of pentamidine: method development, mechanistic insights, and expedient access to novel antiparastitics against diamidine‐resistant parasites. ChemMedChem, 16(22), pp. 3396-3401. (doi: 10.1002/cmdc.202100509) (PMID:34357687)

Mallo, N. et al. (2021) Depletion of a Toxoplasma porin leads to defects in mitochondrial morphology and contacts with the ER. Journal of Cell Science, 134(20), jcs255299. (doi: 10.1242/jcs.255299) (PMID:34523684) (PMCID:PMC8572010)

Cueto-Díaz, E. J. et al. (2021) Synthesis, biological, and photophysical studies of molecular rotor-based fluorescent inhibitors of the Trypanosome Alternative Oxidase. European Journal of Medicinal Chemistry, 2020, 113470. (doi: 10.1016/j.ejmech.2021.113470) (PMID:33940464)

Carruthers, L. V. et al. (2021) Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential. Molecular Microbiology, 116(2), pp. 564-588. (doi: 10.1111/mmi.14733) (PMID:33932053)

2020

Roca Portoles, A., Blanco, G., Sumpton, D., Cloix, C., Mullin, M., Mackay, G. M., O'Neill, K., Lemgruber Soares, L. , Luo, X. and Tait, S. W.G. (2020) Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition. Cell Death and Disease, 11, 616. (doi: 10.1038/s41419-020-02867-2) (PMID:32792521) (PMCID:PMC7426836)

Patil, H., Hughes, K. R., Lemgruber Soares, L. , Philip, N., Dickens, N. , Starnes, G. L. and Waters, A. P. (2020) Zygote morphogenesis but not the establishment of cell polarity in Plasmodium berghei is controlled by the small GTPase, RAB11A. PLoS Pathogens, 16(5), e1008091. (doi: 10.1371/journal.ppat.1008091) (PMID:32463831) (PMCID:PMC7255598)

Black, J. A., Crouch, K. , Lemgruber, L. , Lapsley, C., Dickens, N. , Tosi, L. R.O., Mottram, J. C. and McCulloch, R. (2020) Trypanosoma brucei ATR links DNA damage signalling during antigenic variation with regulation of RNA Polymerase I-transcribed surface antigens. Cell Reports, 30(3), 836-851.e5. (doi: 10.1016/j.celrep.2019.12.049) (PMID:31968257) (PMCID:PMC6988115)

2019

Del Rosario, M. et al. (2019) Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion. EMBO Reports, 20(12), e48896. (doi: 10.15252/embr.201948896) (PMID:31584242) (PMCID:PMC6893294)

Briggs, E., Crouch, K. , Lemgruber Soares, L. , Hamilton, G., Lapsley, C. and McCulloch, R. (2019) Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation. Nucleic Acids Research, 47(17), pp. 9180-9197. (doi: 10.1093/nar/gkz644) (PMID:31350892) (PMCID:PMC6753483)

Currà, C. et al. (2019) Malaria transmission through the mosquito requires the function of the OMD protein. PLoS ONE, 14(9), e0222226. (doi: 10.1371/journal.pone.0222226) (PMID:31553751) (PMCID:PMC6760768)

Gras, S., Jimenez-Ruiz, E. , Klinger, C. M., Schneider, K., Klingl, A., Lemgruber, L. and Meissner, M. (2019) An endocytic-secretory cycle participates in Toxoplasma gondii in motility. PLoS Biology, 17(6), e3000060. (doi: 10.1371/journal.pbio.3000060) (PMID:31233488) (PMCID:PMC6611640)

Dantzler, K. W. et al. (2019) Naturally acquired immunity against immature Plasmodium falciparum gametocytes. Science Translational Medicine, 11(495), eaav3963. (doi: 10.1126/scitranslmed.aav3963) (PMID:31167926) (PMCID:PMC6653583)

Melatti, C., Pieperhoff, M., Lemgruber, L. , Pohl, E., Sheiner, L. and Meissner, M. (2019) A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii. PLoS Pathogens, 15(4), e1007512. (doi: 10.1371/journal.ppat.1007512) (PMID:30947298) (PMCID:PMC6448817)

Cerone, M. et al. (2019) Discovery of sustainable drugs for neglected tropical diseases: cashew nut shell liquid (CNSL)-based hybrids target mitochondrial function and ATP production in Trypanosoma brucei. ChemMedChem, 14(6), pp. 621-635. (doi: 10.1002/cmdc.201800790) (PMID:30664325) (PMCID:PMC6686156)

Nnadi, C., Ebiloma, G. U., Black, J. A., Nwodo, N., Lemgruber, L. , Schmidt, T. J. and De Koning, H. P. (2019) Potent antitrypanosomal activities of 3-aminosteroids against African trypanosomes: investigation of cellular effects and of cross-resistance with existing drugs. Molecules, 24(2), 268. (doi: 10.3390/molecules24020268) (PMID:30642032)

2018

Briggs, E., Crouch, K. , Lemgruber, L. , Lapsley, C. and McCulloch, R. (2018) Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion. PLoS Genetics, 14(12), e1007729. (doi: 10.1371/journal.pgen.1007729) (PMID:30543624) (PMCID:PMC6292569)

2017

Millan, C. R., Acosta-Reyes, F. J., Lagartera, L., Ebiloma, G. U., Lemgruber Soares, L. , Nué Martinez, J. J., Saperas, N., Dardonville, C., De Koning, H. P. and Campos, J. L. (2017) Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast. Nucleic Acids Research, 45(14), pp. 8378-8391. (doi: 10.1093/nar/gkx521) (PMID:28637278) (PMCID:PMC5737332)

Das, S., Lemgruber, L. , Tay, C. L., Baum, J. and Meissner, M. (2017) Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage development. BMC Biology, 15(1), 70. (doi: 10.1186/s12915-017-0406-2) (PMID:28810863) (PMCID:PMC5557482)

Stortz, J. A. et al. (2017) Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei. PLoS Pathogens, 13(7), e1006477. (doi: 10.1371/journal.ppat.1006477) (PMID:28742144) (PMCID:PMC5542689)

Chasen, N. M., Asady, B., Lemgruber, L. , Vommaro, R. C., Kissinger, J. C., Coppens, I. and Moreno, S. N.J. (2017) A glycosylphosphatidylinositol-anchored carbonic anhydrase-related protein of Toxoplasma gondii is important for rhoptry biogenesis and virulence. mSphere, 2(3), e00027-17. (doi: 10.1128/mSphere.00027-17) (PMID:28529974) (PMCID:PMC5437132)

Muthinja, M. J. et al. (2017) Microstructured blood vessel surrogates reveal structural tropism of motile malaria parasites. Advanced Healthcare Materials, 6(6), 1601178. (doi: 10.1002/adhm.201601178) (PMID:28117558)

Periz, J. et al. (2017) Toxoplasma gondii F-actin forms an extensive filamentous network required for material exchange and parasite maturation. eLife, 6, e24119. (doi: 10.7554/eLife.24119) (PMID:28322189) (PMCID:PMC5375643)

Ovciarikova, J., Lemgruber, L. , Stilger, K. L., Sullivan, W. J. and Sheiner, L. (2017) Mitochondrial behaviour throughout the lytic cycle of Toxoplasma gondii. Scientific Reports, 7, 42746. (doi: 10.1038/srep42746) (PMID:28202940) (PMCID:PMC5311943)

2016

Caldas, L. A., Lemgruber Soares, L. , Seabra, S. H., Attias, M. and de Souza, W. (2016) Monitoring of dynamin during the Toxoplasma gondii cell cycle. Pathogens and Disease, 74(9), ftw108. (doi: 10.1093/femspd/ftw108) (PMID:27811048)

Serpeloni, M., Jiménez-Ruiz, E. , Vidal, N. M., Kroeber, C., Andenmatten, N., Lemgruber, L. , Mörking, P., Pall, G. S., Meisner, M. and Ávila, A. R. (2016) UAP56 is a conserved crucial component of a divergent mRNA export pathway in Toxoplasma gondii. Molecular Microbiology, 102(4), pp. 672-689. (doi: 10.1111/mmi.13485) (PMID:27542978) (PMCID:PMC5118106)

Marques, C. A. , Tiengwe, C., Lemgruber Soares, L. , Damasceno, J. D., Scott, A., Paape, D. , Marcello, L. and McCulloch, R. (2016) Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation. Nucleic Acids Research, 44(10), pp. 4763-4784. (doi: 10.1093/nar/gkw147) (PMID:26951375) (PMCID:PMC4889932)

Kehrer, J., Singer, M., Lemgruber, L. , Silva, P. A.G.C., Frischknecht, F. and Mair, G. R. (2016) A putative small solute transporter is responsible for the secretion of G377 and TRAP-containing secretory vesicles during Plasmodium gamete egress and sporozoite motility. PLoS Pathogens, 12(7), e1005734. (doi: 10.1371/journal.ppat.1005734) (PMID:27427910) (PMCID:PMC4948853)

Grewal, J. S. et al. (2016) PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast. Journal of Biological Chemistry, 291, pp. 9492-9500. (doi: 10.1074/jbc.M116.714972) (PMID:26940875) (PMCID:PMC4850289)

Ribeiro, A.R. et al. (2016) Trojan-like internalization of anatase titanium dioxide nanoparticles by human osteoblast cells. Scientific Reports, 6, 23615. (doi: 10.1038/srep23615) (PMID:27021687) (PMCID:PMC4810327)

Eugenio, M., Müller, N., Frasés, S., Almeida-Paes, R., Lima, L. M. T.R., Lemgruber, L. , Farina, M., de Souza, W. and Sant'Anna, C. (2016) Yeast-derived biosynthesis of silver/silver chloride nanoparticles and their antiproliferative activity against bacteria. RSC Advances, 6(12), pp. 9893-9904. (doi: 10.1039/c5ra22727e)

2015

Lemgruber Soares, L. , Sant'Anna, C., Griffiths, C., abud, y., Mhlanga, M., Wallich, R. and Frischknecht, F. (2015) Nanoscopic localization of surface-exposed antigens of Borrelia burgdorferi. Microscopy and Microanalysis, 21(3), pp. 680-688. (doi: 10.1017/S1431927615000318) (PMID:25739645)

2014

Rug, M. et al. (2014) Export of virulence proteins by malaria-infected erythrocytes involves remodeling of host actin cytoskeleton. Blood, 124(3), pp. 3459-3468. (doi: 10.1182/blood-2014-06-583054) (PMID:25139348) (PMCID:PMC4246041)

2013

Hanssen, E. et al. (2013) Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion. Cellular Microbiology, 15(9), pp. 1457-1472. (doi: 10.1111/cmi.12132) (PMID:23461734)

Lemgruber Soares, L. , Kudryashev, M., Dekiwadia, C., Riglar, D. T., Baum, J., Stahlberg, H., Ralph, S. A. and Frischknecht, F. (2013) Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast. Malaria Journal, 12, 25. (doi: 10.1186/1475-2875-12-25) (PMID:23331966) (PMCID:PMC3662607)

2012

Kühni-Boghenbor, K., Ma, M., Lemgruber Soares, L. , Cyrklaff, M., Frischknecht, F., Gaschen, V., Stoffel, M. and Baumgartner, M. (2012) Actin-mediated plasma membrane plasticity of the intracellular parasite Theileria annulata. Cellular Microbiology, 14(12), pp. 1867-1879. (doi: 10.1111/cmi.12006) (PMID:22891986)

Lemgruber Soares, L. , Cyrklaff, M. and Frischknecht, F. (2012) Centrosomes and cell division in apicomplexa. In: Schatten, H. (ed.) The Centrosome. Humana Press: New York, pp. 327-346. ISBN 9781627030342 (doi: 10.1007/978-1-62703-035-9_19)

Lemgruber, L. and Lupetti, P. (2012) Crystalloid body, refractile body and virus-like particles in Apicomplexa: what is in there? Parasitology, 139(3), pp. 285-293. (doi: 10.1017/S0031182011002034) (PMID:22217113)

2011

Lemgruber Soares, L. , Lupetti, P., Martins-Duarte, E. S., Souza, W. d. and Vommaro, R. C. (2011) The organization of the wall filaments and characterization of the matrix structures of Toxoplasma gondii cyst form. Cellular Microbiology, 13(12), pp. 1920-1932. (doi: 10.1111/j.1462-5822.2011.01681.x) (PMID:21899696)

Lemgruber Soares, L. , Lupetti, P., Souza, W. d. and Vommaro, R. C. (2011) New details on the fine structure of the rhoptry of Toxoplasma gondii. Microscopy Research and Technique, 74(9), pp. 812-818. (doi: 10.1002/jemt.20960) (PMID:23939668)

Kudryashev, M., Cyrklaff, M., Alex, B., Lemgruber, L. , Baumeister, W., Wallich, R. and Frischknecht, F. (2011) Evidence of direct cell-cell fusion in Borrelia by cryogenic electron tomography. Cellular Microbiology, 13(5), pp. 731-741. (doi: 10.1111/j.1462-5822.2011.01571.x) (PMID:21276171)

Martins-Duarte, É. S., Lemgruber, L. , Lorente, S. O., Gros, L., Magaraci, F., Gilbert, I. H., de Souza, W. and Vommaro, R. C. (2011) Evaluation of three novel azasterols against Toxoplasma gondii. Veterinary Parasitology, 177(1-2), pp. 157-161. (doi: 10.1016/j.vetpar.2010.11.034) (PMID:21176865)

Singer, M. and Lemgruber, L. (2011) An arrangement of intersecting ideas: the CNC 2010 meeting report. Biotechnology Journal, 6(1), pp. 12-15. (doi: 10.1002/biot.201000389) (PMID:21225990)

2010

Bittencourt-Silvestre, J., Lemgruber Soares, L. and Souza, W. d. (2010) Encystation process of Giardia lamblia : morphological and regulatory aspects. Archives of Microbiology, 192, pp. 259-265. (doi: 10.1007/s00203-010-0554-z) (PMID:20151113)

Lemgruber, L. , Lupetti, P., De Souza, W., Vommaro, R. C. and Da Rocha-Azevedo, B. (2010) The fine structure of the Acanthamoeba polyphaga cyst wall. FEMS Microbiology Letters, 305(2), pp. 170-176. (doi: 10.1111/j.1574-6968.2010.01925.x) (PMID:20199572)

Martins-Duarte, É. S., Lemgruber, L. , de Souza, W. and Vommaro, R. C. (2010) Toxoplasma gondii: Fluconazole and itraconazole activity against toxoplasmosis in a murine model. Experimental Parasitology, 124(4), pp. 466-469. (doi: 10.1016/j.exppara.2009.12.011) (PMID:20045696)

2009

Lemgruber, L. , Kloetzel, J. A., de Souza, W. and Vommaro, R. C. (2009) Toxoplasma gondii: further studies on the subpellicular network. Memorias Do Instituto Oswaldo Cruz, 104(5), pp. 706-709. (doi: 10.1590/S0074-02762009000500007) (PMID:19820829)

Lemgruber, L. , Lupetti, P., de Souza, W. and Vommaro, R.C. (2009) The structure of toxoplasma gondii cyst by quick-freeze/deep-etch technique. Microscopy and Microanalysis, 15(S2), pp. 958-959. (doi: 10.1017/S1431927609095142)

2008

Sant'Anna, C., Pereira, M. G., Lemgruber Soares, L. , de Souza, W. and Cunha e Silva, N. L. (2008) New insights into the morphology of Trypanosoma cruzi reservosome. Microscopy Research and Technique, 71(8), pp. 599-605. (doi: 10.1002/jemt.20592) (PMID:18452191)

Lemgruber, L. , De Souza, W. and Vommaro, R. C. (2008) Freeze-fracture study of the dynamics of Toxoplasma gondii parasitophorous vacuole development. Micron, 39(2), pp. 177-183. (doi: 10.1016/j.micron.2007.01.002) (PMID:17317194)

2005

Magno, R. C., Lemgruber, L. , Vommaro, R. C., De Souza, W. and Attias, M. (2005) Intravacuolar network may act as a mechanical support for Toxoplasma gondii inside the parasitophorous vacuole. Microscopy Research and Technique, 67(1), pp. 45-52. (doi: 10.1002/jemt.20182) (PMID:16025490)

This list was generated on Wed Apr 24 00:49:32 2024 BST.

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