Dr Timothy Palmer

telephone: 01482465511
email: Tim.Palmer@glasgow.ac.uk

R421 Level 4, Institute of C&MS, Davidson Building, Glasgow G12 8QQ

Import to contacts

Publications

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Jump to: 2021 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000
Number of items: 48.

2021

Palmer, Timothy M. and Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 (2021) Nutrient regulation of inflammatory signalling in obesity and vascular disease. Clinical Science, 135(13), pp. 1563-1590. (doi: 10.1042/CS20190768) (PMID:34231841)

2019

Pan, J. et al. (2019) Increased risk of HPV-associated genital cancers in men and women as a consequence of pre-invasive disease. International Journal of Cancer, 145(2), pp. 427-434. (doi: 10.1002/ijc.32126) (PMID:30650180)

2018

Strembitska, Anastasiya, Mancini, Sarah J., Gamwell, Jonathan M., Palmer, Timothy M., Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 and Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase. International Journal of Molecular Sciences, 19(12), 3886. (doi: 10.3390/ijms19123886) (PMID:30563079) (PMCID:PMC6321332)

Mancini, Sarah J., Boyd, Daria, Katwan, Omar J., Strembitska, Anastasiya, Almabrouk, Tarek Ali, Kennedy, Simon ORCID logoORCID: https://orcid.org/0000-0003-0887-5840, Palmer, Timothy M. and Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 (2018) Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms. Scientific Reports, 8, 5276. (doi: 10.1038/s41598-018-23420-4) (PMID:29588466) (PMCID:PMC5869674)

Speirs, Claire, Williams, Jamie J.L., Riches, Kirsten, Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 and Palmer, Timothy M. (2018) Linking energy sensing to suppression of JAK-STAT signalling: a potential route for repurposing AMPK activators? Pharmacological Research, 128, pp. 88-100. (doi: 10.1016/j.phrs.2017.10.001) (PMID:29037480)

Williams, Jamie J.L., Al-Otaiq, Nasser, Mullen, William ORCID logoORCID: https://orcid.org/0000-0002-5685-1563, Burchmore, Richard ORCID logoORCID: https://orcid.org/0000-0003-1663-9004, Liu, Libin, Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316, Schaper, Fred, Pilch, Paul F. and Palmer, Timothy M. (2018) Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nature Communications, 9, 168. (doi: 10.1038/s41467-017-02585-y) (PMID:29330478) (PMCID:PMC5766592)

2017

Mancini, Sarah J., White, Anna D., Bijland, Silvia, Rutherford, Claire, Graham, Delyth ORCID logoORCID: https://orcid.org/0000-0002-7328-4708, Richter, Erik A., Viollet, Benoit, Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887, Palmer, Timothy M. and Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi: 10.1016/j.mce.2016.11.010) (PMID:27840174) (PMCID:PMC5228585)

2016

Heathcote, Helen R., Mancini, Sarah J., Strembitska, Anastasiya, Jamal, Kunzah, Reihill, James A., Palmer, Timothy M., Gould, Gwyn W. ORCID logoORCID: https://orcid.org/0000-0001-6571-2875 and Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 (2016) Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487. Biochemical Journal, 473(24), pp. 4681-4697. (doi: 10.1042/BCJ20160211) (PMID:27784766) (PMCID:PMC5147050)

Rutherford, C. et al. (2016) Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. Science Signaling, 9(453), ra109. (doi: 10.1126/scisignal.aaf8566) (PMID:27919027)

2015

Palmer, Timothy P. and Yarwood, Stephen J. (2015) Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1. Journal of Cell Signaling, 1(1), 1000103. (doi: 10.4172/jcs.1000103)

Parnell, Euan, Palmer, Timothy M. and Yarwood, Stephen J. (2015) The future of EPAC-targeted therapeutics: agonism versus antagonism. Trends in Pharmacological Sciences, 36(4), pp. 203-214. (doi: 10.1016/j.tips.2015.02.003) (PMID:25744542) (PMCID:PMC4392396)

2014

Williams, Jamie, Munro, Kirsten and Palmer, Timothy (2014) Role of ubiquitylation in controlling suppressor of cytokine signalling 3 (SOCS3) function and expression. Cells, 3(2), pp. 546-562. (doi: 10.3390/cells3020546) (PMID:24886706) (PMCID:PMC4092859)

Williams, Jamie J.L. and Palmer, Timothy M. (2014) Cavin-1: caveolae-dependent signalling and cardiovascular disease. Biochemical Society Transactions, 42(2), pp. 284-288. (doi: 10.1042/BST20130270) (PMID:24646232)

2013

Rutherford, C. et al. (2013) Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1. Cell Death and Disease, 4(11), e927. (doi: 10.1038/cddis.2013.455)

Cannavo, A. et al. (2013) β1-adrenergic receptor and sphingosine-1-phosphate receptor 1 (S1PR1) reciprocal downregulation influences cardiac hypertrophic response and progression to heart failure: protective role of S1PR1 cardiac gene therapy. Circulation, 128(15), pp. 1612-1622. (doi: 10.1161/CIRCULATIONAHA.113.002659)

Long, J.S., Crighton, D., O’Prey, J., MacKay, G., Zheng, L., Palmer, T.M., Gottlieb, E. ORCID logoORCID: https://orcid.org/0000-0002-9770-0956 and Ryan, K.M. ORCID logoORCID: https://orcid.org/0000-0002-1059-9681 (2013) Extracellular adenosine sensing—a metabolic cell death priming mechanism downstream of p53. Molecular Cell, 50(3), pp. 394-406. (doi: 10.1016/j.molcel.2013.03.016)

2012

Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 and Palmer, Timothy M. (2012) Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. Expert Opinion on Investigational Drugs, 21(8), pp. 1155-1167. (doi: 10.1517/13543784.2012.696609)

Dondelinger, F., Rogers, S. ORCID logoORCID: https://orcid.org/0000-0003-3578-4477, Filippone, M., Cretella, R., Palmer, T., Smith, R., Millar, A. and Husmeier, D. ORCID logoORCID: https://orcid.org/0000-0003-1673-7413 (2012) Parameter inference in mechanistic models of cellular regulation and signalling pathways using gradient matching. In: WCSB2012 - 9th International Workshop on Computational Systems Biology, Ulm, Germany, 4-6 Jun 2012,

Parnell, Euan, Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168, Palmer, Timothy M., Terrin, Anna, Zaccolo, Manuela and Yarwood, Stephen J. (2012) Regulation of the inflammatory response of vascular endothelial cells by EPAC1. British Journal of Pharmacology, 166(2), pp. 434-446. (doi: 10.1111/j.1476-5381.2011.01808.x)

Milne, Gillian R., Palmer, Timothy M. and Yarwood, Stephen J. (2012) Novel control of cAMP-regulated transcription in vascular endothelial cells. Biochemical Society Transactions, 40(1), pp. 1-5. (doi: 10.1042/BST20110606)

Williams, Jamie J.L. and Palmer, Timothy M. (2012) Unbiased identification of substrates for the Epac1-inducible E3 ubiquitin ligase component SOCS-3. Biochemical Society Transactions, 40(1), pp. 215-218. (doi: 10.1042/BST20110629) (PMID:22260693)

Sands, William A., Woolson, Hayley D., Yarwood, Stephen J. and Palmer, Timothy M. (2012) Exchange protein directly activated by cyclic AMP-1-regulated recruitment of CCAAT/enhancer-binding proteins to the suppressor of cytokine signaling-3 promoter. Methods in Molecular Biology, 809, pp. 201-214. (doi: 10.1007/978-1-61779-376-9_14)

Williams, Jamie J.L. and Palmer, Timothy M. (2012) Interleukin-6 (IL6) signalling and its role in the development of cardiovascular disease. In: Carrasco, João and Mota, Matheus (eds.) Endothelium and Epithelium: Composition, Functions and Pathology. Series: Human anatomy and physiology; Cell biology research progress. Nova Science Publishers: Hauppauge, N.Y., pp. 157-173. ISBN 9781614708742

2011

Lawlor, D.A., Fraser, A., Macdonald-Wallis, C., Nelson, S.M. ORCID logoORCID: https://orcid.org/0000-0002-9099-3047, Palmer, T.M., Davey Smith, G. and Tilling, K. (2011) Maternal and offspring adiposity-related genetic variants and gestational weight gain. American Journal of Clinical Nutrition, 94(1), pp. 149-155. (doi: 10.3945/ajcn.110.010751)

Milne, Gillian and Palmer, Timothy M. (2011) Anti-inflammatory and immunosuppressive effects of the A2A adenosine receptor. Scientific World Journal, 11, pp. 320-339. (doi: 10.1100/tsw.2011.22)

2010

Safhi, Mohammed M. A., Rutherford, Claire, Ledent, Catherine, Sands, William A. and Palmer, Timothy M. (2010) Priming of signal transducer and activator of transcription proteins for cytokine-triggered polyubiquitylation and degradation by the A2a adenosine receptor. Molecular Pharmacology, 77(6), pp. 968-978. (doi: 10.1124/mol.109.062455)

Mundell, S.J., Matharu, A.-L., Palmer, T.M., Benovic, J.L. and Kelly, E. (2010) Deletion of the distal COOH-terminus of the A2B adenosine receptor switches agonist-induced internalisation to an arrestin- and clathrin-independent pathway and inhibits receptor recycling. British Journal of Pharmacology, 159(3), pp. 518-533. (doi: 10.1111/j.1476-5381.2009.00598.x)

Rutherford, C. and Palmer, T.M. (2010) Molecular basis of protective anti-inflammatory signalling by cyclic AMP in the vascular endothelium. In: Choi, S. (ed.) Systems Biology of Signaling Networks. Series: Systems biology (1). Springer, pp. 561-588. ISBN 9781441957962

2009

Woolson, Hayley D., Thomson, Victoria S., Rutherford, Claire, Yarwood, Stephen J. and Palmer, Timothy M. (2009) Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic amp via Epac1-dependent induction of suppressor of cytokine signalling-3. Cellular Signalling, 21(11), pp. 1706-1715. (doi: 10.1016/j.cellsig.2009.07.009) (PMID:32549377) (PMCID:PMC7352853)

Borland, Gillian, Bird, Rebecca J., Palmer, Timothy M. and Yarwood, Stephen J. (2009) Activation of protein kinase Cα by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein β-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells. Journal of Biological Chemistry, 284(26), pp. 17391-17403. (doi: 10.1074/jbc.M109.015370) (PMID:19423709) (PMCID:PMC2719379)

2008

Mair, K.M., MacLean, M.R., Morecroft, I., Dempsie, Y. and Palmer, T.M. (2008) Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts. British Journal of Pharmacology, 155(4), pp. 606-616. (doi: 10.1038/bjp.2008.310) (PMID:18695640) (PMCID:PMC2579673)

Yarwood, S.J., Borland, G., Sands, W.A. and Palmer, T.M. (2008) Identification of CCAAT/Enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene. Journal of Biological Chemistry, 283(11), pp. 6843-6853. (doi: 10.1074/jbc.M710342200)

Palmer, T.M. and Trevethick, M.A. (2008) Suppression of inflammatory and immune responses by the A(2A) adenosine receptor: an introduction. British Journal of Pharmacology, 153, S27-S34. (doi: 10.1038/sj.bjp.0707524) (PMID:18026131)

Sands, W.A. and Palmer, T.M. (2008) Regulating gene transcription in response to cyclic AMP elevation. Cellular Signalling, 20(3), pp. 460-466. (doi: 10.1016/j.cellsig.2007.10.005)

2006

Sands, W.A., Woolson, H.D., Milne, G.R., Rutherford, C. and Palmer, T.M. (2006) Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells. Molecular and Cellular Biology, 26(17), pp. 6333-6346.

Funakoshi, H. et al. (2006) Regulated overexpression of the A(1)-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. Circulation, 114, pp. 2240-2250. (doi: 10.1161/CIRCULATIONAHA.106.620211)

2005

Rutherford, C, Ord-Shrimpton, FU, Sands, WA, Pediani, JD, Benovic, JL, McGrath, JC and Palmer, TM (2005) Phosphorylation-independent internalisation and desensitisation of the human sphingosine-1-phosphate receptor S1P(3). Cellular Signalling, 17, pp. 997-1009. (doi: 10.1016/j.cellsig.2004.11.018)

Sands, WA and Palmer, TM (2005) Adenosine receptors and the control of endothelial cell function in inflammatory disease. Immunology Letters, 101, pp. 1-11. (doi: 10.1016/j.imlet.2005.04.005)

Sands, WA and Palmer, TM (2005) Inhibition of pro-inflammatory cytokine receptor signalling by CAMP in vascular endothelial cells. Biochemical Society Transactions, 33, pp. 1126-1128.

2004

Sands, WA, Martin, AF, Strong, EW and Palmer, TM (2004) Specific inhibition of nuclear factor-kappa B-dependent inflammatory responses by cell type-specific mechanisms upon A(2A) adenosine receptor gene transfer. Molecular Pharmacology, 66, pp. 1147-1159. (doi: 10.1124/mol.104.001107)

2003

Palmer, TA, Ferguson, G and Watterson, KR (2003) Dissecting the regulatory mechanisms controlling inhibitory adenosine receptor signaling. Drug Development Research, 58, pp. 302-314. (doi: 10.1002/ddr.10185)

Perry, CG, Palmer, T, Cleland, SJ, Morton, IJ, Salt, IP ORCID logoORCID: https://orcid.org/0000-0003-0055-3724, Petrie, JR ORCID logoORCID: https://orcid.org/0000-0002-4894-9819, Gould, GW and Connell, JMC (2003) Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action. Clinical Science, 105(2), pp. 187-194. (doi: 10.1042/CS20020320)

2002

Ferguson, G., Watterson, K.R. ORCID logoORCID: https://orcid.org/0000-0003-3819-4026 and Palmer, T.M. (2002) Subtype-specific regulation of receptor internalization and recycling by the carboxyl-terminal domains of the human A(1) and rat A(3) adenosine receptors: Consequences for agonist-stimulated translocation of arrestin3. Biochemistry, 41, pp. 14748-14761. (doi: 10.1021/bi0262911)

Klinger, M, Kuhn, M, Just, H, Stefan, E, Palmer, T, Freissmuth, M and Nanoff, C (2002) Removal of the carboxy terminus of the A(2A)-adenosine receptor blunts constitutive activity: differential effect on cAMP accumulation and MAP kinase stimulation. Naunyn-Schmiedeberg's Archives of Pharmacology, 366, pp. 287-298. (doi: 10.1007/s00210-002-0617-z)

Palmer, T (2002) Molecular regulation of adenosine receptor signalling: implications for the design of novel cardioprotective and anti-inflammatory therapies. Recent Research Developments in Molecular Pharmacology, 1, pp. 53-75.

Watterson, KR ORCID logoORCID: https://orcid.org/0000-0003-3819-4026, Johnston, E, Chalmers, C, Pronin, A, Cook, SJ, Benovic, JL and Palmer, TM (2002) Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2. Journal of Biological Chemistry, 277, pp. 5767-5777. (doi: 10.1074/jbc.M110647200)

2001

Alderton, F., Rakhit, S., Kong, K.C., Palmer, T., Sambi, B., Pyne, S. and Pyne, N.J. (2001) Tethering of the platelet-derived growth factor ß receptor to G-protein-coupled receptors - A novel platform for integrative signaling by these receptor classes in mammalian cells. Journal of Biological Chemistry, 276, pp. 28578-28585. (doi: 10.1074/jbc.M102771200)

2000

Ferguson, Gail, Watterson, Kenneth R. ORCID logoORCID: https://orcid.org/0000-0003-3819-4026 and Palmer, Timothy M. (2000) Subtype-specific kinetics of inhibitory adenosine receptor internalization are determined by sensitivity to phosphorylation by G protein-coupled receptor kinases. Molecular Pharmacology, 57(3), pp. 546-552. (doi: 10.1124/mol.57.3.546) (PMID:10692495)

This list was generated on Mon Jan 5 04:57:10 2026 GMT.
Jump to: Articles | Book Sections | Conference Proceedings
Number of items: 48.

Articles

Palmer, Timothy M. and Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 (2021) Nutrient regulation of inflammatory signalling in obesity and vascular disease. Clinical Science, 135(13), pp. 1563-1590. (doi: 10.1042/CS20190768) (PMID:34231841)

Pan, J. et al. (2019) Increased risk of HPV-associated genital cancers in men and women as a consequence of pre-invasive disease. International Journal of Cancer, 145(2), pp. 427-434. (doi: 10.1002/ijc.32126) (PMID:30650180)

Strembitska, Anastasiya, Mancini, Sarah J., Gamwell, Jonathan M., Palmer, Timothy M., Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316 and Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase. International Journal of Molecular Sciences, 19(12), 3886. (doi: 10.3390/ijms19123886) (PMID:30563079) (PMCID:PMC6321332)

Mancini, Sarah J., Boyd, Daria, Katwan, Omar J., Strembitska, Anastasiya, Almabrouk, Tarek Ali, Kennedy, Simon ORCID logoORCID: https://orcid.org/0000-0003-0887-5840, Palmer, Timothy M. and Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 (2018) Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms. Scientific Reports, 8, 5276. (doi: 10.1038/s41598-018-23420-4) (PMID:29588466) (PMCID:PMC5869674)

Speirs, Claire, Williams, Jamie J.L., Riches, Kirsten, Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 and Palmer, Timothy M. (2018) Linking energy sensing to suppression of JAK-STAT signalling: a potential route for repurposing AMPK activators? Pharmacological Research, 128, pp. 88-100. (doi: 10.1016/j.phrs.2017.10.001) (PMID:29037480)

Williams, Jamie J.L., Al-Otaiq, Nasser, Mullen, William ORCID logoORCID: https://orcid.org/0000-0002-5685-1563, Burchmore, Richard ORCID logoORCID: https://orcid.org/0000-0003-1663-9004, Liu, Libin, Baillie, George S. ORCID logoORCID: https://orcid.org/0000-0003-2469-6316, Schaper, Fred, Pilch, Paul F. and Palmer, Timothy M. (2018) Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nature Communications, 9, 168. (doi: 10.1038/s41467-017-02585-y) (PMID:29330478) (PMCID:PMC5766592)

Mancini, Sarah J., White, Anna D., Bijland, Silvia, Rutherford, Claire, Graham, Delyth ORCID logoORCID: https://orcid.org/0000-0002-7328-4708, Richter, Erik A., Viollet, Benoit, Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887, Palmer, Timothy M. and Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi: 10.1016/j.mce.2016.11.010) (PMID:27840174) (PMCID:PMC5228585)

Heathcote, Helen R., Mancini, Sarah J., Strembitska, Anastasiya, Jamal, Kunzah, Reihill, James A., Palmer, Timothy M., Gould, Gwyn W. ORCID logoORCID: https://orcid.org/0000-0001-6571-2875 and Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 (2016) Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487. Biochemical Journal, 473(24), pp. 4681-4697. (doi: 10.1042/BCJ20160211) (PMID:27784766) (PMCID:PMC5147050)

Rutherford, C. et al. (2016) Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. Science Signaling, 9(453), ra109. (doi: 10.1126/scisignal.aaf8566) (PMID:27919027)

Palmer, Timothy P. and Yarwood, Stephen J. (2015) Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1. Journal of Cell Signaling, 1(1), 1000103. (doi: 10.4172/jcs.1000103)

Parnell, Euan, Palmer, Timothy M. and Yarwood, Stephen J. (2015) The future of EPAC-targeted therapeutics: agonism versus antagonism. Trends in Pharmacological Sciences, 36(4), pp. 203-214. (doi: 10.1016/j.tips.2015.02.003) (PMID:25744542) (PMCID:PMC4392396)

Williams, Jamie, Munro, Kirsten and Palmer, Timothy (2014) Role of ubiquitylation in controlling suppressor of cytokine signalling 3 (SOCS3) function and expression. Cells, 3(2), pp. 546-562. (doi: 10.3390/cells3020546) (PMID:24886706) (PMCID:PMC4092859)

Williams, Jamie J.L. and Palmer, Timothy M. (2014) Cavin-1: caveolae-dependent signalling and cardiovascular disease. Biochemical Society Transactions, 42(2), pp. 284-288. (doi: 10.1042/BST20130270) (PMID:24646232)

Rutherford, C. et al. (2013) Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1. Cell Death and Disease, 4(11), e927. (doi: 10.1038/cddis.2013.455)

Cannavo, A. et al. (2013) β1-adrenergic receptor and sphingosine-1-phosphate receptor 1 (S1PR1) reciprocal downregulation influences cardiac hypertrophic response and progression to heart failure: protective role of S1PR1 cardiac gene therapy. Circulation, 128(15), pp. 1612-1622. (doi: 10.1161/CIRCULATIONAHA.113.002659)

Long, J.S., Crighton, D., O’Prey, J., MacKay, G., Zheng, L., Palmer, T.M., Gottlieb, E. ORCID logoORCID: https://orcid.org/0000-0002-9770-0956 and Ryan, K.M. ORCID logoORCID: https://orcid.org/0000-0002-1059-9681 (2013) Extracellular adenosine sensing—a metabolic cell death priming mechanism downstream of p53. Molecular Cell, 50(3), pp. 394-406. (doi: 10.1016/j.molcel.2013.03.016)

Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 and Palmer, Timothy M. (2012) Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. Expert Opinion on Investigational Drugs, 21(8), pp. 1155-1167. (doi: 10.1517/13543784.2012.696609)

Parnell, Euan, Smith, Brian O. ORCID logoORCID: https://orcid.org/0000-0003-3363-4168, Palmer, Timothy M., Terrin, Anna, Zaccolo, Manuela and Yarwood, Stephen J. (2012) Regulation of the inflammatory response of vascular endothelial cells by EPAC1. British Journal of Pharmacology, 166(2), pp. 434-446. (doi: 10.1111/j.1476-5381.2011.01808.x)

Milne, Gillian R., Palmer, Timothy M. and Yarwood, Stephen J. (2012) Novel control of cAMP-regulated transcription in vascular endothelial cells. Biochemical Society Transactions, 40(1), pp. 1-5. (doi: 10.1042/BST20110606)

Williams, Jamie J.L. and Palmer, Timothy M. (2012) Unbiased identification of substrates for the Epac1-inducible E3 ubiquitin ligase component SOCS-3. Biochemical Society Transactions, 40(1), pp. 215-218. (doi: 10.1042/BST20110629) (PMID:22260693)

Sands, William A., Woolson, Hayley D., Yarwood, Stephen J. and Palmer, Timothy M. (2012) Exchange protein directly activated by cyclic AMP-1-regulated recruitment of CCAAT/enhancer-binding proteins to the suppressor of cytokine signaling-3 promoter. Methods in Molecular Biology, 809, pp. 201-214. (doi: 10.1007/978-1-61779-376-9_14)

Lawlor, D.A., Fraser, A., Macdonald-Wallis, C., Nelson, S.M. ORCID logoORCID: https://orcid.org/0000-0002-9099-3047, Palmer, T.M., Davey Smith, G. and Tilling, K. (2011) Maternal and offspring adiposity-related genetic variants and gestational weight gain. American Journal of Clinical Nutrition, 94(1), pp. 149-155. (doi: 10.3945/ajcn.110.010751)

Milne, Gillian and Palmer, Timothy M. (2011) Anti-inflammatory and immunosuppressive effects of the A2A adenosine receptor. Scientific World Journal, 11, pp. 320-339. (doi: 10.1100/tsw.2011.22)

Safhi, Mohammed M. A., Rutherford, Claire, Ledent, Catherine, Sands, William A. and Palmer, Timothy M. (2010) Priming of signal transducer and activator of transcription proteins for cytokine-triggered polyubiquitylation and degradation by the A2a adenosine receptor. Molecular Pharmacology, 77(6), pp. 968-978. (doi: 10.1124/mol.109.062455)

Mundell, S.J., Matharu, A.-L., Palmer, T.M., Benovic, J.L. and Kelly, E. (2010) Deletion of the distal COOH-terminus of the A2B adenosine receptor switches agonist-induced internalisation to an arrestin- and clathrin-independent pathway and inhibits receptor recycling. British Journal of Pharmacology, 159(3), pp. 518-533. (doi: 10.1111/j.1476-5381.2009.00598.x)

Woolson, Hayley D., Thomson, Victoria S., Rutherford, Claire, Yarwood, Stephen J. and Palmer, Timothy M. (2009) Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic amp via Epac1-dependent induction of suppressor of cytokine signalling-3. Cellular Signalling, 21(11), pp. 1706-1715. (doi: 10.1016/j.cellsig.2009.07.009) (PMID:32549377) (PMCID:PMC7352853)

Borland, Gillian, Bird, Rebecca J., Palmer, Timothy M. and Yarwood, Stephen J. (2009) Activation of protein kinase Cα by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein β-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells. Journal of Biological Chemistry, 284(26), pp. 17391-17403. (doi: 10.1074/jbc.M109.015370) (PMID:19423709) (PMCID:PMC2719379)

Mair, K.M., MacLean, M.R., Morecroft, I., Dempsie, Y. and Palmer, T.M. (2008) Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts. British Journal of Pharmacology, 155(4), pp. 606-616. (doi: 10.1038/bjp.2008.310) (PMID:18695640) (PMCID:PMC2579673)

Yarwood, S.J., Borland, G., Sands, W.A. and Palmer, T.M. (2008) Identification of CCAAT/Enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene. Journal of Biological Chemistry, 283(11), pp. 6843-6853. (doi: 10.1074/jbc.M710342200)

Palmer, T.M. and Trevethick, M.A. (2008) Suppression of inflammatory and immune responses by the A(2A) adenosine receptor: an introduction. British Journal of Pharmacology, 153, S27-S34. (doi: 10.1038/sj.bjp.0707524) (PMID:18026131)

Sands, W.A. and Palmer, T.M. (2008) Regulating gene transcription in response to cyclic AMP elevation. Cellular Signalling, 20(3), pp. 460-466. (doi: 10.1016/j.cellsig.2007.10.005)

Sands, W.A., Woolson, H.D., Milne, G.R., Rutherford, C. and Palmer, T.M. (2006) Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells. Molecular and Cellular Biology, 26(17), pp. 6333-6346.

Funakoshi, H. et al. (2006) Regulated overexpression of the A(1)-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. Circulation, 114, pp. 2240-2250. (doi: 10.1161/CIRCULATIONAHA.106.620211)

Rutherford, C, Ord-Shrimpton, FU, Sands, WA, Pediani, JD, Benovic, JL, McGrath, JC and Palmer, TM (2005) Phosphorylation-independent internalisation and desensitisation of the human sphingosine-1-phosphate receptor S1P(3). Cellular Signalling, 17, pp. 997-1009. (doi: 10.1016/j.cellsig.2004.11.018)

Sands, WA and Palmer, TM (2005) Adenosine receptors and the control of endothelial cell function in inflammatory disease. Immunology Letters, 101, pp. 1-11. (doi: 10.1016/j.imlet.2005.04.005)

Sands, WA and Palmer, TM (2005) Inhibition of pro-inflammatory cytokine receptor signalling by CAMP in vascular endothelial cells. Biochemical Society Transactions, 33, pp. 1126-1128.

Sands, WA, Martin, AF, Strong, EW and Palmer, TM (2004) Specific inhibition of nuclear factor-kappa B-dependent inflammatory responses by cell type-specific mechanisms upon A(2A) adenosine receptor gene transfer. Molecular Pharmacology, 66, pp. 1147-1159. (doi: 10.1124/mol.104.001107)

Palmer, TA, Ferguson, G and Watterson, KR (2003) Dissecting the regulatory mechanisms controlling inhibitory adenosine receptor signaling. Drug Development Research, 58, pp. 302-314. (doi: 10.1002/ddr.10185)

Perry, CG, Palmer, T, Cleland, SJ, Morton, IJ, Salt, IP ORCID logoORCID: https://orcid.org/0000-0003-0055-3724, Petrie, JR ORCID logoORCID: https://orcid.org/0000-0002-4894-9819, Gould, GW and Connell, JMC (2003) Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action. Clinical Science, 105(2), pp. 187-194. (doi: 10.1042/CS20020320)

Ferguson, G., Watterson, K.R. ORCID logoORCID: https://orcid.org/0000-0003-3819-4026 and Palmer, T.M. (2002) Subtype-specific regulation of receptor internalization and recycling by the carboxyl-terminal domains of the human A(1) and rat A(3) adenosine receptors: Consequences for agonist-stimulated translocation of arrestin3. Biochemistry, 41, pp. 14748-14761. (doi: 10.1021/bi0262911)

Klinger, M, Kuhn, M, Just, H, Stefan, E, Palmer, T, Freissmuth, M and Nanoff, C (2002) Removal of the carboxy terminus of the A(2A)-adenosine receptor blunts constitutive activity: differential effect on cAMP accumulation and MAP kinase stimulation. Naunyn-Schmiedeberg's Archives of Pharmacology, 366, pp. 287-298. (doi: 10.1007/s00210-002-0617-z)

Palmer, T (2002) Molecular regulation of adenosine receptor signalling: implications for the design of novel cardioprotective and anti-inflammatory therapies. Recent Research Developments in Molecular Pharmacology, 1, pp. 53-75.

Watterson, KR ORCID logoORCID: https://orcid.org/0000-0003-3819-4026, Johnston, E, Chalmers, C, Pronin, A, Cook, SJ, Benovic, JL and Palmer, TM (2002) Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2. Journal of Biological Chemistry, 277, pp. 5767-5777. (doi: 10.1074/jbc.M110647200)

Alderton, F., Rakhit, S., Kong, K.C., Palmer, T., Sambi, B., Pyne, S. and Pyne, N.J. (2001) Tethering of the platelet-derived growth factor ß receptor to G-protein-coupled receptors - A novel platform for integrative signaling by these receptor classes in mammalian cells. Journal of Biological Chemistry, 276, pp. 28578-28585. (doi: 10.1074/jbc.M102771200)

Ferguson, Gail, Watterson, Kenneth R. ORCID logoORCID: https://orcid.org/0000-0003-3819-4026 and Palmer, Timothy M. (2000) Subtype-specific kinetics of inhibitory adenosine receptor internalization are determined by sensitivity to phosphorylation by G protein-coupled receptor kinases. Molecular Pharmacology, 57(3), pp. 546-552. (doi: 10.1124/mol.57.3.546) (PMID:10692495)

Book Sections

Williams, Jamie J.L. and Palmer, Timothy M. (2012) Interleukin-6 (IL6) signalling and its role in the development of cardiovascular disease. In: Carrasco, João and Mota, Matheus (eds.) Endothelium and Epithelium: Composition, Functions and Pathology. Series: Human anatomy and physiology; Cell biology research progress. Nova Science Publishers: Hauppauge, N.Y., pp. 157-173. ISBN 9781614708742

Rutherford, C. and Palmer, T.M. (2010) Molecular basis of protective anti-inflammatory signalling by cyclic AMP in the vascular endothelium. In: Choi, S. (ed.) Systems Biology of Signaling Networks. Series: Systems biology (1). Springer, pp. 561-588. ISBN 9781441957962

Conference Proceedings

Dondelinger, F., Rogers, S. ORCID logoORCID: https://orcid.org/0000-0003-3578-4477, Filippone, M., Cretella, R., Palmer, T., Smith, R., Millar, A. and Husmeier, D. ORCID logoORCID: https://orcid.org/0000-0003-1673-7413 (2012) Parameter inference in mechanistic models of cellular regulation and signalling pathways using gradient matching. In: WCSB2012 - 9th International Workshop on Computational Systems Biology, Ulm, Germany, 4-6 Jun 2012,

This list was generated on Mon Jan 5 04:57:10 2026 GMT.