Professor Iain Morgan
- Affiliate (MVLS College Services)
email:
Iain.Morgan@glasgow.ac.uk
R203A Level 2, Centre for Virus Research, Mcrobert Wing, Glasgow G61 1QH
Publications
2015
Gauson, E. J., Donaldson, M. , Dornan, E. S., Wang, X., Bristol, M., Bodily, J. M. and Morgan, I. M. (2015) Evidence supporting a role for TopBP1 and Brd4 in the initiation but not continuation of human papillomavirus 16 E1/E2-mediated DNA replication. Journal of Virology, 89(9), pp. 4980-4991. (doi: 10.1128/JVI.00335-15) (PMID:25694599) (PMCID:PMC4403487)
2014
Gauson, E. J., Windle, B., Donaldson, M. , Cafarel, M. M., Dornan, E., Coleman, N., Herzyk, P. , Henderson, S. C., Wang, X. and Morgan, I. (2014) Regulation of human genome expression and RNA splicing by human papillomavirus 16 E2 protein. Virology, 468-70, pp. 10-18. (doi: 10.1016/j.virol.2014.07.022)
2012
Finlay, M., Yuan, Z., Morgan, I.M., Campo, M. and Nasir, L. (2012) Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53. Veterinary Research, 43, p. 81. (doi: 10.1186/1297-9716-43-81)
Donaldson, M.M. , Mackintosh, L.J., Bodily, J.M., Dornan, E.S., Laimins, L.A. and Morgan, I.M. (2012) An interaction between human papillomavirus 16 E2 and TopBP1is required for optimum viral DNA replication and episomal genome establishment. Journal of Virology, 86(23), pp. 12806-12815. (doi: 10.1128/JVI.01002-12)
2011
King, L.E., Dornan, E.S., Donaldson, M.M. and Morgan, I.M. (2011) Human papillomavirus 16 E2 stability and transcriptional activation is enhanced by E1 via a direct protein–protein interaction. Virology, 414(1), pp. 26-33. (doi: 10.1016/j.virol.2011.03.002)
2010
King, L.E., Fisk, J.C., Dornan, E.S., Donaldson, M.M. , Melendy, T. and Morgan, I.M. (2010) Human papillomavirus E1 and E2 mediated DNA replication is not arrested by DNA damage signalling. Virology, 406(1), pp. 95-102. (doi: 10.1016/j.virol.2010.06.033)
Arendt, M. L., Nasir, L. and Morgan, I. M. (2010) The human and canine TERT promoters function equivalently in human and canine cells. Veterinary and Comparative Oncology, 8(4), pp. 310-316. (doi: 10.1111/j.1476-5829.2010.00227.x)
Blackford, A.N. et al. (2010) Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation. Proceedings of the National Academy of Sciences of the United States of America, 107(27), pp. 12251-12256. (doi: 10.1073/pnas.0914605107)
2009
Johansson, C., Graham, S.V. , Dornan, E.S. and Morgan, I.M. (2009) The human papillomavirus 16 E2 protein is stabilised in S phase. Virology, 394(2), pp. 194-199. (doi: 10.1016/j.virol.2009.08.046) (PMID:19781729)
Mackintosh, L. J., de Koning, M. N. C., Quint, W. G. V., ter Schegget, J., Morgan, I. M., Herd, R. M. and Campo, M. S. (2009) Presence of beta human papillomaviruses in nonmelanoma skin cancer from organ transplant recipients and immunocompetent patients in the West of Scotland. British Journal of Dermatology, 161(1), pp. 56-62. (doi: 10.1111/j.1365-2133.2009.09146.x)
Arendt, M., Nasir, L. and Morgan, I.M. (2009) Oncolytic gene therapy for canine cancers: teaching old dog viruses new tricks. Veterinary and Comparative Oncology, 7(3), pp. 153-161. (doi: 10.1111/j.1476-5829.2009.00187.x)
Arendt, M.L., Nasir, L. and Morgan, I.M. (2009) A novel two-step transcriptional activation system for gene therapy directed toward epithelial cells. Molecular Cancer Therapeutics, 8(12), pp. 3244-3254. (doi: 10.1158/1535-7163.MCT-09-0543)
Finlay, M., Yuan, Z.Q., Burden, F., Trawford, A., Morgan, I.M., Campo, M.S. and Nasir, L. (2009) The detection of Bovine Papillomavirus type 1 DNA in flies. Virus Research, 144(1-2), pp. 315-317. (doi: 10.1016/j.virusres.2009.04.015)
Gobeil, P.A.M., Yuan, Z.Q., Gault, E.A., Morgan, I.M., Campo, M.S. and Nasir, L. (2009) Small interfering RNA targeting bovine papillomavirus type 1 E2 induces apoptosis in equine sarcoid transformed fibroblasts. Virus Research, 145(1), pp. 162-165. (doi: 10.1016/j.virusres.2009.06.019)
Morris, J.S. , Nixon, C., King, O.J.A., Morgan, I.M. and Philbey, A.M. (2009) Expression of TopBP1 in canine mammary neoplasia in relation to histological type, Ki67, ER alpha and p53. Veterinary Journal, 179(3), pp. 422-429. (doi: 10.1016/j.tvjl.2007.10.025)
2008
Wright, R.H.G., Dornan, E.S., Donaldson, M.M. , MacFarlane, M., Herzyk, P. and Morgan, I.M. (2008) TopBP1 contains transcriptional regulatory domains and regulates gene pathways involved in breast cancer. In: Breast Cancer Research 2008, London, UK, 13 May 2008, P21. (doi: 10.1186/bcr 1905)
Morris, J. , Nixon, C., Bruck, A., Nasir, L., Morgan, I.M. and Philbey, A. (2008) Immunohistochemical expression of TopBP1 in feline mammary neoplasia in relation to histological grade, Ki67, ERα and p53. Veterinary Journal, 175(2), pp. 218-226. (doi: 10.1016/j.tvjl.2007.01.006)
Arendt, M.L., Morris, J. , Nasir, L. and Morgan, I.M. (2008) Abstracts presented at the ESVONC spring meeting, Cambridge, UK, 23-25 March 2007. Veterinary and Comparative Oncology, 6(1), pp. 65-83.
2007
Going, J.J., Nixon, C., Dornan, E.S., Boner, W. , Donaldson, M.M. and Morgan, I.M. (2007) Aberrant expression of TopBP1 in breast cancer. Histopathology, 50(4), pp. 418-424. (doi: 10.1111/j.1365-2559.2007.02622.x)
Donaldson, M.M. , Boner, W. and Morgan, I.M. (2007) TopBP1 regulates human papillomavirus type 16 E2 interaction with chromatin. Journal of Virology, 81(8), pp. 4338-4342. (doi: 10.1128/JVI.02353-06) (PMID:17287259)
Gobeil, P., Gault, E.A., Campo, M.S., Gow, J., Morgan, I.M. and Nasir, L. (2007) Equine sarcoids are not induced by an infectious cell line. Equine Veterinary Journal, 39, pp. 189-191. (doi: 10.2746/042516407X179879)
Nasir, L., Gault, E., Morgan, I., Chambers, G., Ellsmore, V. and Campo, M. (2007) Identification and functional analysis of sequence variants in the long control region and the E2 open reading frame of bovine papillomavirus type 1 isolated from equine sarcoids. Virology, 364, pp. 355-361. (doi: 10.1016/j.virol.2007.02.019)
2006
Wright, R.H.G., Dornan, E.S., Donaldson, M.M. and Morgan, I.M. (2006) TopBP1 contains a transcriptional activation domain suppressed by two adjacent BRCT domains. Biochemical Journal, 400, pp. 573-582. (doi: 10.1042/BJ20060831)
2005
Okoye, A., Cordano, P., Taylor, E.R., Morgan, I.M., Everett, R. and Campo, M.S. (2005) Human papillomavirus 16 L2 inhibits the transcriptional activation function, but not the DNA replication function, of HPV-16 E2. Virus Research, 108(1), pp. 1-14. (doi: 10.1016/j.virusres.2004.07.004)
Morgan, I. (2005) Detection and quantitation of HPV DNA replication by Southern blotting and real-time PCR. Methods in Molecular Medicine, 119, pp. 349-362.
2004
McPhillips, M. G., Veerapraditsin, T., Cumming, S. A., Karali, D., Milligan, S. G., Boner, W. , Morgan, I. M. and Graham, S. V. (2004) SF2/ASF binds the human papillomavirus type 16 late RNA control element and is regulated during differentiation of virus-infected epithelial cells. Journal of Virology, 78, pp. 10598-10605. (doi: 10.1128/JVI.78.19.10598-10605.2004) (PMID:15367627) (PMCID:PMC516382)
2003
Taylor, E. R., Boner, W. , Dornan, E. S., Corr, E. M. and Morgan, I. M. (2003) UVB irradiation reduces the half-life and transactivation potential of the human papillomavirus 16 E2 protein. Oncogene, 22, pp. 4469-4477. (doi: 10.1038/sj.onc.1206746) (PMID:12881703)
Taylor, E. R., Dornan, E. S., Boner, W. , Connolly, J. A., McNair, S., Kannouche, P., Lehmann, A.R. and Morgan, I. M. (2003) The fidelity of HPV16 E1/E2-mediated DNA replication. Journal of Biological Chemistry, 278, pp. 52223-52230. (doi: 10.1074/jbc.M308779200) (PMID:14559922)
Taylor, E. and Morgan, I. (2003) A novel technique with enhanced detection and quantitation of HPV-16 E1- and E2-mediated DNA replication. Virology, 315, pp. 103-109. (doi: 10.1016/S0042-6822(03)00588-9)
2002
Boner, W. and Morgan, I. M. (2002) Novel cellular interacting partners of the human papillomavirus 16 transcription/replication factor E2. Virus Research, 90, pp. 113-118. (doi: 10.1016/S0168-1702(02)00145-4) (PMID:12457967)
Boner, W. , Taylor, E. R., Tsirimonaki, E., Yamane, K., Campo, M. S. and Morgan, I. M. (2002) A functional interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1. Journal of Biological Chemistry, 277, pp. 22297-22303. (doi: 10.1074/jbc.M202163200) (PMID:11934899)
2001
Beniston, R.G., Morgan, I.M., O'Brien, V. and Campo, M.S. (2001) Quercetin, E7 and p53 in papillomavirus oncogenic cell transformation. Carcinogenesis, 22, pp. 1069-1076.
Vance, K., Campo, M. and Morgan, I. (2001) A novel silencer element in the bovine papillomavirus type 4 promoter represses the transcriptional response to papillomavirus E2 protein. Journal of Virology, 75, pp. 2829-2838.
Articles
Gauson, E. J., Donaldson, M. , Dornan, E. S., Wang, X., Bristol, M., Bodily, J. M. and Morgan, I. M. (2015) Evidence supporting a role for TopBP1 and Brd4 in the initiation but not continuation of human papillomavirus 16 E1/E2-mediated DNA replication. Journal of Virology, 89(9), pp. 4980-4991. (doi: 10.1128/JVI.00335-15) (PMID:25694599) (PMCID:PMC4403487)
Gauson, E. J., Windle, B., Donaldson, M. , Cafarel, M. M., Dornan, E., Coleman, N., Herzyk, P. , Henderson, S. C., Wang, X. and Morgan, I. (2014) Regulation of human genome expression and RNA splicing by human papillomavirus 16 E2 protein. Virology, 468-70, pp. 10-18. (doi: 10.1016/j.virol.2014.07.022)
Finlay, M., Yuan, Z., Morgan, I.M., Campo, M. and Nasir, L. (2012) Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53. Veterinary Research, 43, p. 81. (doi: 10.1186/1297-9716-43-81)
Donaldson, M.M. , Mackintosh, L.J., Bodily, J.M., Dornan, E.S., Laimins, L.A. and Morgan, I.M. (2012) An interaction between human papillomavirus 16 E2 and TopBP1is required for optimum viral DNA replication and episomal genome establishment. Journal of Virology, 86(23), pp. 12806-12815. (doi: 10.1128/JVI.01002-12)
King, L.E., Dornan, E.S., Donaldson, M.M. and Morgan, I.M. (2011) Human papillomavirus 16 E2 stability and transcriptional activation is enhanced by E1 via a direct protein–protein interaction. Virology, 414(1), pp. 26-33. (doi: 10.1016/j.virol.2011.03.002)
King, L.E., Fisk, J.C., Dornan, E.S., Donaldson, M.M. , Melendy, T. and Morgan, I.M. (2010) Human papillomavirus E1 and E2 mediated DNA replication is not arrested by DNA damage signalling. Virology, 406(1), pp. 95-102. (doi: 10.1016/j.virol.2010.06.033)
Arendt, M. L., Nasir, L. and Morgan, I. M. (2010) The human and canine TERT promoters function equivalently in human and canine cells. Veterinary and Comparative Oncology, 8(4), pp. 310-316. (doi: 10.1111/j.1476-5829.2010.00227.x)
Blackford, A.N. et al. (2010) Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation. Proceedings of the National Academy of Sciences of the United States of America, 107(27), pp. 12251-12256. (doi: 10.1073/pnas.0914605107)
Johansson, C., Graham, S.V. , Dornan, E.S. and Morgan, I.M. (2009) The human papillomavirus 16 E2 protein is stabilised in S phase. Virology, 394(2), pp. 194-199. (doi: 10.1016/j.virol.2009.08.046) (PMID:19781729)
Mackintosh, L. J., de Koning, M. N. C., Quint, W. G. V., ter Schegget, J., Morgan, I. M., Herd, R. M. and Campo, M. S. (2009) Presence of beta human papillomaviruses in nonmelanoma skin cancer from organ transplant recipients and immunocompetent patients in the West of Scotland. British Journal of Dermatology, 161(1), pp. 56-62. (doi: 10.1111/j.1365-2133.2009.09146.x)
Arendt, M., Nasir, L. and Morgan, I.M. (2009) Oncolytic gene therapy for canine cancers: teaching old dog viruses new tricks. Veterinary and Comparative Oncology, 7(3), pp. 153-161. (doi: 10.1111/j.1476-5829.2009.00187.x)
Arendt, M.L., Nasir, L. and Morgan, I.M. (2009) A novel two-step transcriptional activation system for gene therapy directed toward epithelial cells. Molecular Cancer Therapeutics, 8(12), pp. 3244-3254. (doi: 10.1158/1535-7163.MCT-09-0543)
Finlay, M., Yuan, Z.Q., Burden, F., Trawford, A., Morgan, I.M., Campo, M.S. and Nasir, L. (2009) The detection of Bovine Papillomavirus type 1 DNA in flies. Virus Research, 144(1-2), pp. 315-317. (doi: 10.1016/j.virusres.2009.04.015)
Gobeil, P.A.M., Yuan, Z.Q., Gault, E.A., Morgan, I.M., Campo, M.S. and Nasir, L. (2009) Small interfering RNA targeting bovine papillomavirus type 1 E2 induces apoptosis in equine sarcoid transformed fibroblasts. Virus Research, 145(1), pp. 162-165. (doi: 10.1016/j.virusres.2009.06.019)
Morris, J.S. , Nixon, C., King, O.J.A., Morgan, I.M. and Philbey, A.M. (2009) Expression of TopBP1 in canine mammary neoplasia in relation to histological type, Ki67, ER alpha and p53. Veterinary Journal, 179(3), pp. 422-429. (doi: 10.1016/j.tvjl.2007.10.025)
Morris, J. , Nixon, C., Bruck, A., Nasir, L., Morgan, I.M. and Philbey, A. (2008) Immunohistochemical expression of TopBP1 in feline mammary neoplasia in relation to histological grade, Ki67, ERα and p53. Veterinary Journal, 175(2), pp. 218-226. (doi: 10.1016/j.tvjl.2007.01.006)
Arendt, M.L., Morris, J. , Nasir, L. and Morgan, I.M. (2008) Abstracts presented at the ESVONC spring meeting, Cambridge, UK, 23-25 March 2007. Veterinary and Comparative Oncology, 6(1), pp. 65-83.
Going, J.J., Nixon, C., Dornan, E.S., Boner, W. , Donaldson, M.M. and Morgan, I.M. (2007) Aberrant expression of TopBP1 in breast cancer. Histopathology, 50(4), pp. 418-424. (doi: 10.1111/j.1365-2559.2007.02622.x)
Donaldson, M.M. , Boner, W. and Morgan, I.M. (2007) TopBP1 regulates human papillomavirus type 16 E2 interaction with chromatin. Journal of Virology, 81(8), pp. 4338-4342. (doi: 10.1128/JVI.02353-06) (PMID:17287259)
Gobeil, P., Gault, E.A., Campo, M.S., Gow, J., Morgan, I.M. and Nasir, L. (2007) Equine sarcoids are not induced by an infectious cell line. Equine Veterinary Journal, 39, pp. 189-191. (doi: 10.2746/042516407X179879)
Nasir, L., Gault, E., Morgan, I., Chambers, G., Ellsmore, V. and Campo, M. (2007) Identification and functional analysis of sequence variants in the long control region and the E2 open reading frame of bovine papillomavirus type 1 isolated from equine sarcoids. Virology, 364, pp. 355-361. (doi: 10.1016/j.virol.2007.02.019)
Wright, R.H.G., Dornan, E.S., Donaldson, M.M. and Morgan, I.M. (2006) TopBP1 contains a transcriptional activation domain suppressed by two adjacent BRCT domains. Biochemical Journal, 400, pp. 573-582. (doi: 10.1042/BJ20060831)
Okoye, A., Cordano, P., Taylor, E.R., Morgan, I.M., Everett, R. and Campo, M.S. (2005) Human papillomavirus 16 L2 inhibits the transcriptional activation function, but not the DNA replication function, of HPV-16 E2. Virus Research, 108(1), pp. 1-14. (doi: 10.1016/j.virusres.2004.07.004)
Morgan, I. (2005) Detection and quantitation of HPV DNA replication by Southern blotting and real-time PCR. Methods in Molecular Medicine, 119, pp. 349-362.
McPhillips, M. G., Veerapraditsin, T., Cumming, S. A., Karali, D., Milligan, S. G., Boner, W. , Morgan, I. M. and Graham, S. V. (2004) SF2/ASF binds the human papillomavirus type 16 late RNA control element and is regulated during differentiation of virus-infected epithelial cells. Journal of Virology, 78, pp. 10598-10605. (doi: 10.1128/JVI.78.19.10598-10605.2004) (PMID:15367627) (PMCID:PMC516382)
Taylor, E. R., Boner, W. , Dornan, E. S., Corr, E. M. and Morgan, I. M. (2003) UVB irradiation reduces the half-life and transactivation potential of the human papillomavirus 16 E2 protein. Oncogene, 22, pp. 4469-4477. (doi: 10.1038/sj.onc.1206746) (PMID:12881703)
Taylor, E. R., Dornan, E. S., Boner, W. , Connolly, J. A., McNair, S., Kannouche, P., Lehmann, A.R. and Morgan, I. M. (2003) The fidelity of HPV16 E1/E2-mediated DNA replication. Journal of Biological Chemistry, 278, pp. 52223-52230. (doi: 10.1074/jbc.M308779200) (PMID:14559922)
Taylor, E. and Morgan, I. (2003) A novel technique with enhanced detection and quantitation of HPV-16 E1- and E2-mediated DNA replication. Virology, 315, pp. 103-109. (doi: 10.1016/S0042-6822(03)00588-9)
Boner, W. and Morgan, I. M. (2002) Novel cellular interacting partners of the human papillomavirus 16 transcription/replication factor E2. Virus Research, 90, pp. 113-118. (doi: 10.1016/S0168-1702(02)00145-4) (PMID:12457967)
Boner, W. , Taylor, E. R., Tsirimonaki, E., Yamane, K., Campo, M. S. and Morgan, I. M. (2002) A functional interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1. Journal of Biological Chemistry, 277, pp. 22297-22303. (doi: 10.1074/jbc.M202163200) (PMID:11934899)
Beniston, R.G., Morgan, I.M., O'Brien, V. and Campo, M.S. (2001) Quercetin, E7 and p53 in papillomavirus oncogenic cell transformation. Carcinogenesis, 22, pp. 1069-1076.
Vance, K., Campo, M. and Morgan, I. (2001) A novel silencer element in the bovine papillomavirus type 4 promoter represses the transcriptional response to papillomavirus E2 protein. Journal of Virology, 75, pp. 2829-2838.
Conference Proceedings
Wright, R.H.G., Dornan, E.S., Donaldson, M.M. , MacFarlane, M., Herzyk, P. and Morgan, I.M. (2008) TopBP1 contains transcriptional regulatory domains and regulates gene pathways involved in breast cancer. In: Breast Cancer Research 2008, London, UK, 13 May 2008, P21. (doi: 10.1186/bcr 1905)