Professor Margaret MacLean

  • Visiting Professor (Institute of Cardiovascular & Medical Sciences)
  • Associate (School of Life Sciences)

email: Mandy.MacLean@glasgow.ac.uk

Room 448, West Medical Building, University of Glasgow, G12 8qq

Publications

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Jump to: 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2003 | 2002 | 2001 | 1999 | 1998
Number of items: 58.

2019

Mair, K. M., Harvey, K. Y., Henry, A. D., Hillyard, D. Z., Nilsen, M. and MacLean, M. R. (2019) Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension. European Respiratory Journal, 53(6), 1801524. (doi: 10.1183/13993003.01524-2018) (PMID:30923189) (PMCID:PMC6581204)

Docherty, C. K., Nilsen, M. and MacLean, M. R. (2019) Influence of 2-methoxyestradiol and sex on hypoxia-induced pulmonary hypertension and hypoxia-inducible factor‐1‐α. Journal of the American Heart Association, 8(5), e011628. (doi: 10.1161/JAHA.118.011628) (PMID:30819028) (PMCID:PMC6474940)

MacLean, M.R., Church, C., MacKenzie, A., Jayasekera, G. and Mair, K. (2019) Pulmonary hypertension. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 439-447. ISBN 9783030164805 (doi:10.1007/978-3-030-16481-2_41)

2018

Docherty, C. K., Harvey, K. Y., Mair, K. M., Griffin, S., Denver, N. and MacLean, M. R. (2018) The role of sex in the pathophysiology of pulmonary hypertension. In: Kerkhof, P. L.M. and Miller, V. M. (eds.) Sex-Specific Analysis of Cardiovascular Function. Series: Advances in experimental medicine and biology (1065). Springer: Cham, pp. 511-528. ISBN 9783319779317 (doi:10.1007/978-3-319-77932-4_31)

Dean, A., Gregorc, T., Docherty, C. K., Harvey, K. Y., Nilsen, M., Morrell, N. W. and MacLean, M. R. (2018) Role of the aryl hydrocarbon receptor in Sugen 5416-induced experimental pulmonary hypertension. American Journal of Respiratory Cell and Molecular Biology, 58(3), pp. 320-330. (doi: 10.1165/rcmb.2017-0260OC) (PMID:28956952)

MacLean, M. (M.) R. (2018) The serotonin hypothesis in pulmonary hypertension revisited: targets for novel therapies (2017 Grover Conference Series). Pulmonary Circulation, 8(2), pp. 1-9. (doi: 10.1177/2045894018759125) (PMID:29468941)

2017

Hood, K. Y., Mair, K. M., Harvey, A. P., Montezano, A. C., Touyz, R. M. and MacLean, M. R. (2017) Serotonin signaling through the 5-HT1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(7), pp. 1361-1370. (doi: 10.1161/ATVBAHA.116.308929) (PMID:28473438) (PMCID:PMC5478178)

2016

MacLean, M. (2016) Klotho and pulmonary hypertension: spinning a yarn or the thread of life? Hypertension, 68(5), pp. 1106-1107. (doi: 10.1161/hypertensionaha.116.08292) (PMID:27672024)

Awad, K. S., West, J. D., de Jesus Perez, V. and MacLean, M. (2016) Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series). Pulmonary Circulation, 6(3), pp. 285-294. (doi: 10.1086/688034) (PMID:27683605) (PMCID:PMC5019081)

Hood, K. Y., Montezano, A. C., Harvey, A. P., Nilsen, M., MacLean, M. R. and Touyz, R. M. (2016) Nicotinamide adenine dinucleotide phosphate oxidase–mediated redox signaling and vascular remodeling by 16α-hydroxyestrone in human pulmonary artery cells. Hypertension, 68(3), pp. 796-808. (doi: 10.1161/HYPERTENSIONAHA.116.07668) (PMID:27402919) (PMCID:PMC4978604)

Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S. , MacLean, M. R., Montezano, A. and Touyz, R. M. (2016) Ang(1-7) influences ET-1 signaling through Mas: ETBR interactions: implications in pulmonary hypertension. Journal of Hypertension, 34(Supl 1), e216. (doi: 10.1097/01.hjh.0000500475.07008.db) (PMID:27754060)

Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S. , Montezano, A. C., MacLean, M. R. and Touyz, R. M. (2016) ANG-(1-7) and ET-1, a new partnership. Journal of Hypertension, 34, e382. (doi: 10.1097/01.hjh.0000500977.99529.fe) (PMID:27754197)

Dean, A., Nilsen, M., Loughlin, L., Salt, I. P. and MacLean, M. R. (2016) Metformin reverses development of pulmonary hypertension via aromatase inhibition. Hypertension, 68(2), pp. 446-454. (doi: 10.1161/HYPERTENSIONAHA.116.07353) (PMID:27296990)

Johansen, A. K. Z., Dean, A., Morecroft, I., Hood, K., Nilsen, M., Loughlin, L., Anagnostopoulou, A., Touyz, R. M. , White, K. and MacLean, M. R. (2016) The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1 pulmonary circulation. Pulmonary Circulation, 6(1), pp. 82-92. (doi: 10.1086/685023) (PMID:27162617) (PMCID:PMC4860551)

Stevens, H. C., Deng, L., Grant, J. S., Pinel, K., Thomas, M., Morrell, N. W., MacLean, M. R. and Baker, A. (2016) Regulation and function of miR-214 in pulmonary arterial hypertension. Pulmonary Circulation, 6(1), pp. 109-117. (doi: 10.1086/685079) (PMID:27162619) (PMCID:PMC4860547)

2015

Deng, L. et al. (2015) MicroRNA-143 activation regulates smooth muscle and endothelial cell crosstalk in pulmonary arterial hypertension. Circulation Research, 117(10), pp. 870-883. (doi: 10.1161/CIRCRESAHA.115.306806) (PMID:26311719) (PMCID:PMC4620852)

Hemnes, A. R., Kiely, D. G., Cockrill, B. A., Safdar, Z., Wilson, V. J., Al Hazmi, M., Preston, I. R., MacLean, M. and Lahm, T. (2015) Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute. Pulmonary Circulation, 5(3), pp. 435-465. (doi: 10.1086/682230)

Wallace, E. , Morrell, N. W., Yang, X. D., Long, L., Stevens, H., Nilsen, M., Loughlin, L., Mair, K. M., Baker, A. H. and MacLean, M. R. (2015) A sex-specific microRNA-96/5HT1B Axis influences development of pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine, 191(12), pp. 1432-1442. (doi: 10.1164/rccm.201412-2148OC) (PMID:25871906) (PMCID:PMC4476563)

Wright, A. F., Ewart, M.-A., Mair, K., Nilsen, M., Dempsie, Y., Loughlin, L. and MacLean, M. R. (2015) Oestrogen receptor alpha in pulmonary hypertension. Cardiovascular Research, 106(2), pp. 206-216. (doi: 10.1093/cvr/cvv106) (PMID:25765937) (PMCID:PMC4615797)

Mair, K., Yang, X. D., Long, L., White, K., Wallace, E. , Ewart, M.-A., Docherty, C., Morrell, N. W. and MacLean, M. (2015) Sex affects bone morphogenetic protein type II receptor signaling in pulmonary artery smooth muscle cells. American Journal of Respiratory and Critical Care Medicine, 191(6), pp. 693-703. (doi: 10.1164/rccm.201410-1802OC) (PMID:25608111) (PMCID:PMC4384779)

2014

Mair, K. M. et al. (2014) Sex-dependent influence of endogenous estrogen in pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine, 190(4), pp. 456-467. (doi: 10.1164/rccm.201403-0483OC) (PMID:24956156) (PMCID:PMC4214128)

White, K. et al. (2014) Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis. Hypertension, 64(1), pp. 185-194. (doi: 10.1161/HYPERTENSIONAHA.113.03037)

Mair, K.M., Johansen, A.K.Z., Wright, A.F., Wallace, E. and MacLean, M.R. (2014) Pulmonary arterial hypertension: basis of sex differences in incidence and treatment response. British Journal of Pharmacology, 1(3), pp. 567-579. (doi: 10.1111/bph.12281)

2013

Grant, J. S., Morecroft, I., Dempsie, Y., van Rooij, E., MacLean, M. R. and Baker, A. H. (2013) Transient but not genetic loss of miR-451 attenuates the development of pulmonary arterial hypertension. Pulmonary Circulation, 3(4), pp. 840-850. (doi: 10.1086/674751) (PMID:25006399) (PMCID:PMC4070830)

Grant, J. S., White, K., MacLean, M. R. and Baker, A. H. (2013) MicroRNAs in pulmonary arterial remodeling. Cellular and Molecular Life Sciences, 70(23), pp. 4479-4494. (doi: 10.1007/s00018-013-1382-5)

Dempsie, Y. and Maclean, M. R. (2013) The influence of gender on the development of pulmonary arterial hypertension. Experimental Physiology, 98, pp. 1257-1261. (doi: 10.1113/expphysiol.2012.069120)

Dempsie, Y., MacRitchie, N.A., White, K., Morecroft, I., Wright, A.F., Nilsen, M., Loughlin, L., Mair, K.M. and MacLean, M.R. (2013) Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension. Cardiovascular Research, 99(1), pp. 24-34. (doi: 10.1093/cvr/cvt064) (PMID:23519266) (PMCID:PMC3687748)

Austin, E. D., Johansen, A. K., Alzoubi, A., Lahm, T., West, J., Tofovic, S. P., MacLean, M. R. and Oka, M. (2013) Gender, sex hormones and pulmonary hypertension. Pulmonary Circulation, 3(2), pp. 294-314. (doi: 10.4103/2045-8932.114756) (PMID:24015330) (PMCID:PMC3757824)

Hansmann, G., von Gise, A., MacLean, M.R. and Archer, S.L. (2013) The first Keystone Symposia Conference on pulmonary vascular disease and right ventricular dysfunction: current concepts and future therapies. Pulmonary Circulation, 3(2), pp. 275-277. (doi: 10.4103/2045-8932.114751)

Ciuclan, L. et al. (2013) Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression. American Journal of Respiratory and Critical Care Medicine, 187(1), pp. 78-89. (doi: 10.1164/rccm.201206-1028OC)

2012

Baranowska-Kuczko, M., MacLean, M. R., Kozłowska, H. and Malinowska, B. (2012) Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery. Pharmacological Research, 66(3), pp. 251-259. (doi: 10.1016/j.phrs.2012.05.004)

Caruso, P. et al. (2012) A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples. Circulation Research, 111(3), pp. 290-300. (doi: 10.1161/CIRCRESAHA.112.267591)

McDonald, R. A., Hata, A., MacLean, M. R., Morrell, N. W. and Baker, A. H. (2012) MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling. Cardiovascular Research, 93(4), pp. 594-604. (doi: 10.1093/cvr/cvr299)

Morecroft, I., White, K., Caruso, P., Nilsen, M., Loughlin, L., Alba, R., Reynolds, P.N., Danilov, S.M., Baker, A.H. and MacLean, M.R. (2012) Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension. Molecular Therapy, 20(8), pp. 1516-1528. (doi: 10.1038/mt.2012.70)

White, K. et al. (2012) Activity of the Estrogen-Metabolizing Enzyme Cytochrome P450 1B1 Influences the Development of Pulmonary Arterial Hypertension. Circulation, 126(9), pp. 1087-1098. (doi: 10.1161/CIRCULATIONAHA.111.062927)

2011

Dempsie, Y., Nilsen, M., White, K., Mair, K., Loughlin, L., Ambartsumian, N., Rabinovitch, M. and MacLean, M. (2011) Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females. Respiratory Research, 12(1), p. 159. (doi: 10.1186/1465-9921-12-159)

White, K., Loughlin, L., Maqbool, Z., Nilsen, M., McClure, J. , Dempsie, Y., Baker, A. H. and MacLean, M. R. (2011) Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH. Physiological Genomics, 43(8), pp. 417-437. (doi: 10.1152/physiolgenomics.00249.2010)

White, K., Dempsie, Y., Nilsen, M., Wright, A. F., Loughlin, L. and MacLean, M. R. (2011) The serotonin transporter, gender, and 17β oestradiol in the development of pulmonary arterial hypertension. Cardiovascular Research, 90(2), pp. 373-382. (doi: 10.1093/cvr/cvq408)

2010

Caruso, P. et al. (2010) Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(4), pp. 716-723. (doi: 10.1161/ATVBAHA.109.202028)

MacLean, M. R. and Dempsie, Y. (2010) The serotonin hypothesis of pulmonary hypertension revisited. In: Membrane Receptors, Channels and Transporters in Pulmonary Circulation. Series: Advances in experimental medicine and biology ;; v. 661, 661. Humana Press: New York, pp. 309-322. ISBN 9781607614999 (doi:10.1007/978-1-60761-500-2_20)

Morecroft, I., Pang, L., Baranowska, M., Nilsen, M., Loughlin, L., Dempsie, Y., Millet, C. and MacLean, M. R. (2010) In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Cardiovascular Research, 85(3), pp. 593-603. (doi: 10.1093/cvr/cvp306) (PMID:19736308)

Morecroft, I., Pang, L., Baranowska, M., Nilsen, M., Loughlin, L., Dempsie, Y., Millet, C. and MacLean, M. R. (2010) In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Cardiovascular Research, 85(3), pp. 593-603. (doi: 10.1093/cvr/cvp306) (PMID:19736308)

Kelland, N.F., Bagnall, A.J., Morecroft, I., Gulliver-Sloan, F.H., Dempsie, Y., Nilsen, M., Yanagisawa, M., MacLean, M.R., Kotelevtsev, Y.V. and Webb, D.J. (2010) Endothelial ET limits vascular remodelling and development of pulmonary hypertension during hypoxia. Journal of Vascular Research, 47(1), pp. 16-22. (doi: 10.1159/000231717) (PMID:19672104)

2009

Morecroft, I., Murray, A., Nilsen, M., Gurney, A.M. and MacLean, M.R. (2009) Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension. British Journal of Pharmacology, 157(7), pp. 1241-1249. (doi: 10.1111/j.1476-5381.2009.00283.x) (PMID:19508393) (PMCID:PMC2743843)

Page, C. and MacLean, M.R. (2009) Novel pharmacological approaches to airway and pulmonary vascular disease. Current Opinion in Pharmacology, 9(3), pp. 229-230. (doi: 10.1016/j.coph.2009.04.003)

MacLean, M.R. and Dempsie, Y. (2009) Serotonin and pulmonary hypertension—from bench to bedside? Current Opinion in Pharmacology, 9(3), pp. 281-286. (doi: 10.1016/j.coph.2009.02.005)

Morrell, N.W. et al. (2009) Cellular and molecular basis of pulmonary arterial hypertension. Journal of the American College of Cardiology, 54(1 Supp), S20-S31. (doi: 10.1016/j.jacc.2009.04.018)

2008

Mair, K.M., MacLean, M.R., Morecroft, I., Dempsie, Y. and Palmer, T.M. (2008) Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts. British Journal of Pharmacology, 155(4), pp. 606-616. (doi: 10.1038/bjp.2008.310) (PMID:18695640) (PMCID:PMC2579673)

Dempsie, Y. et al. (2008) Converging Evidence in Support of the Serotonin Hypothesis of Dexfenfluramine-Induced Pulmonary Hypertension With Novel Transgenic Mice. Circulation, 117(22), pp. 2928-2937. (doi: 10.1161/CIRCULATIONAHA.108.767558)

Dempsie, Y. and MacLean, M.R. (2008) Pulmonary hypertension: therapeutic targets within the serotonin system. British Journal of Pharmacology, 155(4), pp. 455-462. (doi: 10.1038/bjp.2008.241)

2007

MacLean, M. (2007) Pulmonary hypertension and the serotonin hypothesis: where are we now? International Journal of Clinical Practice, 61(S156), pp. 27-31. (doi: 10.1111/j.1742-1241.2007.01497.x)

2003

Murray, F., MacLean, M.R. and Pyne, N.J. (2003) An assessment of the role of the inhibitory gamma subunit of the retinal cyclic GMP phosphodiesterase and its effect on the p42/p44 mitogen-activated protein kinase pathway in animal and cellular models of pulmonary hypertension. British Journal of Pharmacology, 138, pp. 1313-1319. (doi: 10.1038/sj.bjp.0705190)

2002

Fisher, C., MacLean, M., Morecroft, I., Seed, A., Johnston, F., Hillier, C. and McMurray, J. (2002) Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart? Circulation, 106, pp. 292-295. (doi: 10.1161/01.CIR.0000025630.05387.45)

Murray, F., MacLean, M.R. and Pyne, N.J. (2002) Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension. British Journal of Pharmacology, 137(8), pp. 1187-1194. (doi: 10.1038/sj.bjp.0704984)

2001

Welsh, D. J., Peacock, A. J., MacLean, M. and Harnett, M. (2001) Chronic hypoxia induces constitutive p38 mitogen-activated protein kinase activity that correlates with enhanced cellular proliferation in fibroblasts from rat pulmonary but not systemic arteries. American Journal of Respiratory and Critical Care Medicine, 164(2), pp. 282-289. (doi: 10.1164/ajrccm.164.2.2008054)

1999

Cowburn, P. J., Cleland, J. G.F., McArthur, J. D., MacLean, M. R., McMurray, J. J.V. , Dargie, H. J. and Morton, J. J. (1999) EndothelinB receptors are functionally important in mediating vasoconstriction in the systemic circulation in patients with left ventricular systolic dysfunction. Journal of the American College of Cardiology, 33(4), pp. 932-938. (doi: 10.1016/s0735-1097(98)00663-9) (PMID:10091818)

1998

Cowburn, P. J., Cleland, J. G.F., McArthur, J. D., MacLean, M. R., McMurray, J. J.V. and Dargie, H. J. (1998) Short-term haemodynamic effects of BQ-123, a selective endothelin ETA-receptor antagonist, in chronic heart failure. Lancet, 352(9123), pp. 201-202. (doi: 10.1016/s0140-6736(05)77807-7) (PMID:9683214)

Cowburn, P. J., Cleland, J. G.F., McArthur, J. D., MacLean, M. R., McMurray, J. J.V. and Dargie, H. J. (1998) Pulmonary and systemic responses to exogenous endothelin-1 in patients with left ventricular dysfunction. Journal of Cardiovascular Pharmacology, 31(Sup 1), S290-S293. (doi: 10.1097/00005344-199800001-00081) (PMID:9595462)

This list was generated on Wed Oct 20 17:33:48 2021 BST.
Number of items: 58.

Articles

Mair, K. M., Harvey, K. Y., Henry, A. D., Hillyard, D. Z., Nilsen, M. and MacLean, M. R. (2019) Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension. European Respiratory Journal, 53(6), 1801524. (doi: 10.1183/13993003.01524-2018) (PMID:30923189) (PMCID:PMC6581204)

Docherty, C. K., Nilsen, M. and MacLean, M. R. (2019) Influence of 2-methoxyestradiol and sex on hypoxia-induced pulmonary hypertension and hypoxia-inducible factor‐1‐α. Journal of the American Heart Association, 8(5), e011628. (doi: 10.1161/JAHA.118.011628) (PMID:30819028) (PMCID:PMC6474940)

Dean, A., Gregorc, T., Docherty, C. K., Harvey, K. Y., Nilsen, M., Morrell, N. W. and MacLean, M. R. (2018) Role of the aryl hydrocarbon receptor in Sugen 5416-induced experimental pulmonary hypertension. American Journal of Respiratory Cell and Molecular Biology, 58(3), pp. 320-330. (doi: 10.1165/rcmb.2017-0260OC) (PMID:28956952)

MacLean, M. (M.) R. (2018) The serotonin hypothesis in pulmonary hypertension revisited: targets for novel therapies (2017 Grover Conference Series). Pulmonary Circulation, 8(2), pp. 1-9. (doi: 10.1177/2045894018759125) (PMID:29468941)

Hood, K. Y., Mair, K. M., Harvey, A. P., Montezano, A. C., Touyz, R. M. and MacLean, M. R. (2017) Serotonin signaling through the 5-HT1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(7), pp. 1361-1370. (doi: 10.1161/ATVBAHA.116.308929) (PMID:28473438) (PMCID:PMC5478178)

MacLean, M. (2016) Klotho and pulmonary hypertension: spinning a yarn or the thread of life? Hypertension, 68(5), pp. 1106-1107. (doi: 10.1161/hypertensionaha.116.08292) (PMID:27672024)

Awad, K. S., West, J. D., de Jesus Perez, V. and MacLean, M. (2016) Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series). Pulmonary Circulation, 6(3), pp. 285-294. (doi: 10.1086/688034) (PMID:27683605) (PMCID:PMC5019081)

Hood, K. Y., Montezano, A. C., Harvey, A. P., Nilsen, M., MacLean, M. R. and Touyz, R. M. (2016) Nicotinamide adenine dinucleotide phosphate oxidase–mediated redox signaling and vascular remodeling by 16α-hydroxyestrone in human pulmonary artery cells. Hypertension, 68(3), pp. 796-808. (doi: 10.1161/HYPERTENSIONAHA.116.07668) (PMID:27402919) (PMCID:PMC4978604)

Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S. , MacLean, M. R., Montezano, A. and Touyz, R. M. (2016) Ang(1-7) influences ET-1 signaling through Mas: ETBR interactions: implications in pulmonary hypertension. Journal of Hypertension, 34(Supl 1), e216. (doi: 10.1097/01.hjh.0000500475.07008.db) (PMID:27754060)

Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S. , Montezano, A. C., MacLean, M. R. and Touyz, R. M. (2016) ANG-(1-7) and ET-1, a new partnership. Journal of Hypertension, 34, e382. (doi: 10.1097/01.hjh.0000500977.99529.fe) (PMID:27754197)

Dean, A., Nilsen, M., Loughlin, L., Salt, I. P. and MacLean, M. R. (2016) Metformin reverses development of pulmonary hypertension via aromatase inhibition. Hypertension, 68(2), pp. 446-454. (doi: 10.1161/HYPERTENSIONAHA.116.07353) (PMID:27296990)

Johansen, A. K. Z., Dean, A., Morecroft, I., Hood, K., Nilsen, M., Loughlin, L., Anagnostopoulou, A., Touyz, R. M. , White, K. and MacLean, M. R. (2016) The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1 pulmonary circulation. Pulmonary Circulation, 6(1), pp. 82-92. (doi: 10.1086/685023) (PMID:27162617) (PMCID:PMC4860551)

Stevens, H. C., Deng, L., Grant, J. S., Pinel, K., Thomas, M., Morrell, N. W., MacLean, M. R. and Baker, A. (2016) Regulation and function of miR-214 in pulmonary arterial hypertension. Pulmonary Circulation, 6(1), pp. 109-117. (doi: 10.1086/685079) (PMID:27162619) (PMCID:PMC4860547)

Deng, L. et al. (2015) MicroRNA-143 activation regulates smooth muscle and endothelial cell crosstalk in pulmonary arterial hypertension. Circulation Research, 117(10), pp. 870-883. (doi: 10.1161/CIRCRESAHA.115.306806) (PMID:26311719) (PMCID:PMC4620852)

Hemnes, A. R., Kiely, D. G., Cockrill, B. A., Safdar, Z., Wilson, V. J., Al Hazmi, M., Preston, I. R., MacLean, M. and Lahm, T. (2015) Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute. Pulmonary Circulation, 5(3), pp. 435-465. (doi: 10.1086/682230)

Wallace, E. , Morrell, N. W., Yang, X. D., Long, L., Stevens, H., Nilsen, M., Loughlin, L., Mair, K. M., Baker, A. H. and MacLean, M. R. (2015) A sex-specific microRNA-96/5HT1B Axis influences development of pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine, 191(12), pp. 1432-1442. (doi: 10.1164/rccm.201412-2148OC) (PMID:25871906) (PMCID:PMC4476563)

Wright, A. F., Ewart, M.-A., Mair, K., Nilsen, M., Dempsie, Y., Loughlin, L. and MacLean, M. R. (2015) Oestrogen receptor alpha in pulmonary hypertension. Cardiovascular Research, 106(2), pp. 206-216. (doi: 10.1093/cvr/cvv106) (PMID:25765937) (PMCID:PMC4615797)

Mair, K., Yang, X. D., Long, L., White, K., Wallace, E. , Ewart, M.-A., Docherty, C., Morrell, N. W. and MacLean, M. (2015) Sex affects bone morphogenetic protein type II receptor signaling in pulmonary artery smooth muscle cells. American Journal of Respiratory and Critical Care Medicine, 191(6), pp. 693-703. (doi: 10.1164/rccm.201410-1802OC) (PMID:25608111) (PMCID:PMC4384779)

Mair, K. M. et al. (2014) Sex-dependent influence of endogenous estrogen in pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine, 190(4), pp. 456-467. (doi: 10.1164/rccm.201403-0483OC) (PMID:24956156) (PMCID:PMC4214128)

White, K. et al. (2014) Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis. Hypertension, 64(1), pp. 185-194. (doi: 10.1161/HYPERTENSIONAHA.113.03037)

Mair, K.M., Johansen, A.K.Z., Wright, A.F., Wallace, E. and MacLean, M.R. (2014) Pulmonary arterial hypertension: basis of sex differences in incidence and treatment response. British Journal of Pharmacology, 1(3), pp. 567-579. (doi: 10.1111/bph.12281)

Grant, J. S., Morecroft, I., Dempsie, Y., van Rooij, E., MacLean, M. R. and Baker, A. H. (2013) Transient but not genetic loss of miR-451 attenuates the development of pulmonary arterial hypertension. Pulmonary Circulation, 3(4), pp. 840-850. (doi: 10.1086/674751) (PMID:25006399) (PMCID:PMC4070830)

Grant, J. S., White, K., MacLean, M. R. and Baker, A. H. (2013) MicroRNAs in pulmonary arterial remodeling. Cellular and Molecular Life Sciences, 70(23), pp. 4479-4494. (doi: 10.1007/s00018-013-1382-5)

Dempsie, Y. and Maclean, M. R. (2013) The influence of gender on the development of pulmonary arterial hypertension. Experimental Physiology, 98, pp. 1257-1261. (doi: 10.1113/expphysiol.2012.069120)

Dempsie, Y., MacRitchie, N.A., White, K., Morecroft, I., Wright, A.F., Nilsen, M., Loughlin, L., Mair, K.M. and MacLean, M.R. (2013) Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension. Cardiovascular Research, 99(1), pp. 24-34. (doi: 10.1093/cvr/cvt064) (PMID:23519266) (PMCID:PMC3687748)

Austin, E. D., Johansen, A. K., Alzoubi, A., Lahm, T., West, J., Tofovic, S. P., MacLean, M. R. and Oka, M. (2013) Gender, sex hormones and pulmonary hypertension. Pulmonary Circulation, 3(2), pp. 294-314. (doi: 10.4103/2045-8932.114756) (PMID:24015330) (PMCID:PMC3757824)

Hansmann, G., von Gise, A., MacLean, M.R. and Archer, S.L. (2013) The first Keystone Symposia Conference on pulmonary vascular disease and right ventricular dysfunction: current concepts and future therapies. Pulmonary Circulation, 3(2), pp. 275-277. (doi: 10.4103/2045-8932.114751)

Ciuclan, L. et al. (2013) Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression. American Journal of Respiratory and Critical Care Medicine, 187(1), pp. 78-89. (doi: 10.1164/rccm.201206-1028OC)

Baranowska-Kuczko, M., MacLean, M. R., Kozłowska, H. and Malinowska, B. (2012) Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery. Pharmacological Research, 66(3), pp. 251-259. (doi: 10.1016/j.phrs.2012.05.004)

Caruso, P. et al. (2012) A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples. Circulation Research, 111(3), pp. 290-300. (doi: 10.1161/CIRCRESAHA.112.267591)

McDonald, R. A., Hata, A., MacLean, M. R., Morrell, N. W. and Baker, A. H. (2012) MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling. Cardiovascular Research, 93(4), pp. 594-604. (doi: 10.1093/cvr/cvr299)

Morecroft, I., White, K., Caruso, P., Nilsen, M., Loughlin, L., Alba, R., Reynolds, P.N., Danilov, S.M., Baker, A.H. and MacLean, M.R. (2012) Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension. Molecular Therapy, 20(8), pp. 1516-1528. (doi: 10.1038/mt.2012.70)

White, K. et al. (2012) Activity of the Estrogen-Metabolizing Enzyme Cytochrome P450 1B1 Influences the Development of Pulmonary Arterial Hypertension. Circulation, 126(9), pp. 1087-1098. (doi: 10.1161/CIRCULATIONAHA.111.062927)

Dempsie, Y., Nilsen, M., White, K., Mair, K., Loughlin, L., Ambartsumian, N., Rabinovitch, M. and MacLean, M. (2011) Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females. Respiratory Research, 12(1), p. 159. (doi: 10.1186/1465-9921-12-159)

White, K., Loughlin, L., Maqbool, Z., Nilsen, M., McClure, J. , Dempsie, Y., Baker, A. H. and MacLean, M. R. (2011) Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH. Physiological Genomics, 43(8), pp. 417-437. (doi: 10.1152/physiolgenomics.00249.2010)

White, K., Dempsie, Y., Nilsen, M., Wright, A. F., Loughlin, L. and MacLean, M. R. (2011) The serotonin transporter, gender, and 17β oestradiol in the development of pulmonary arterial hypertension. Cardiovascular Research, 90(2), pp. 373-382. (doi: 10.1093/cvr/cvq408)

Caruso, P. et al. (2010) Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(4), pp. 716-723. (doi: 10.1161/ATVBAHA.109.202028)

Morecroft, I., Pang, L., Baranowska, M., Nilsen, M., Loughlin, L., Dempsie, Y., Millet, C. and MacLean, M. R. (2010) In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Cardiovascular Research, 85(3), pp. 593-603. (doi: 10.1093/cvr/cvp306) (PMID:19736308)

Morecroft, I., Pang, L., Baranowska, M., Nilsen, M., Loughlin, L., Dempsie, Y., Millet, C. and MacLean, M. R. (2010) In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Cardiovascular Research, 85(3), pp. 593-603. (doi: 10.1093/cvr/cvp306) (PMID:19736308)

Kelland, N.F., Bagnall, A.J., Morecroft, I., Gulliver-Sloan, F.H., Dempsie, Y., Nilsen, M., Yanagisawa, M., MacLean, M.R., Kotelevtsev, Y.V. and Webb, D.J. (2010) Endothelial ET limits vascular remodelling and development of pulmonary hypertension during hypoxia. Journal of Vascular Research, 47(1), pp. 16-22. (doi: 10.1159/000231717) (PMID:19672104)

Morecroft, I., Murray, A., Nilsen, M., Gurney, A.M. and MacLean, M.R. (2009) Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension. British Journal of Pharmacology, 157(7), pp. 1241-1249. (doi: 10.1111/j.1476-5381.2009.00283.x) (PMID:19508393) (PMCID:PMC2743843)

Page, C. and MacLean, M.R. (2009) Novel pharmacological approaches to airway and pulmonary vascular disease. Current Opinion in Pharmacology, 9(3), pp. 229-230. (doi: 10.1016/j.coph.2009.04.003)

MacLean, M.R. and Dempsie, Y. (2009) Serotonin and pulmonary hypertension—from bench to bedside? Current Opinion in Pharmacology, 9(3), pp. 281-286. (doi: 10.1016/j.coph.2009.02.005)

Morrell, N.W. et al. (2009) Cellular and molecular basis of pulmonary arterial hypertension. Journal of the American College of Cardiology, 54(1 Supp), S20-S31. (doi: 10.1016/j.jacc.2009.04.018)

Mair, K.M., MacLean, M.R., Morecroft, I., Dempsie, Y. and Palmer, T.M. (2008) Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts. British Journal of Pharmacology, 155(4), pp. 606-616. (doi: 10.1038/bjp.2008.310) (PMID:18695640) (PMCID:PMC2579673)

Dempsie, Y. et al. (2008) Converging Evidence in Support of the Serotonin Hypothesis of Dexfenfluramine-Induced Pulmonary Hypertension With Novel Transgenic Mice. Circulation, 117(22), pp. 2928-2937. (doi: 10.1161/CIRCULATIONAHA.108.767558)

Dempsie, Y. and MacLean, M.R. (2008) Pulmonary hypertension: therapeutic targets within the serotonin system. British Journal of Pharmacology, 155(4), pp. 455-462. (doi: 10.1038/bjp.2008.241)

MacLean, M. (2007) Pulmonary hypertension and the serotonin hypothesis: where are we now? International Journal of Clinical Practice, 61(S156), pp. 27-31. (doi: 10.1111/j.1742-1241.2007.01497.x)

Murray, F., MacLean, M.R. and Pyne, N.J. (2003) An assessment of the role of the inhibitory gamma subunit of the retinal cyclic GMP phosphodiesterase and its effect on the p42/p44 mitogen-activated protein kinase pathway in animal and cellular models of pulmonary hypertension. British Journal of Pharmacology, 138, pp. 1313-1319. (doi: 10.1038/sj.bjp.0705190)

Fisher, C., MacLean, M., Morecroft, I., Seed, A., Johnston, F., Hillier, C. and McMurray, J. (2002) Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart? Circulation, 106, pp. 292-295. (doi: 10.1161/01.CIR.0000025630.05387.45)

Murray, F., MacLean, M.R. and Pyne, N.J. (2002) Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension. British Journal of Pharmacology, 137(8), pp. 1187-1194. (doi: 10.1038/sj.bjp.0704984)

Welsh, D. J., Peacock, A. J., MacLean, M. and Harnett, M. (2001) Chronic hypoxia induces constitutive p38 mitogen-activated protein kinase activity that correlates with enhanced cellular proliferation in fibroblasts from rat pulmonary but not systemic arteries. American Journal of Respiratory and Critical Care Medicine, 164(2), pp. 282-289. (doi: 10.1164/ajrccm.164.2.2008054)

Cowburn, P. J., Cleland, J. G.F., McArthur, J. D., MacLean, M. R., McMurray, J. J.V. , Dargie, H. J. and Morton, J. J. (1999) EndothelinB receptors are functionally important in mediating vasoconstriction in the systemic circulation in patients with left ventricular systolic dysfunction. Journal of the American College of Cardiology, 33(4), pp. 932-938. (doi: 10.1016/s0735-1097(98)00663-9) (PMID:10091818)

Cowburn, P. J., Cleland, J. G.F., McArthur, J. D., MacLean, M. R., McMurray, J. J.V. and Dargie, H. J. (1998) Short-term haemodynamic effects of BQ-123, a selective endothelin ETA-receptor antagonist, in chronic heart failure. Lancet, 352(9123), pp. 201-202. (doi: 10.1016/s0140-6736(05)77807-7) (PMID:9683214)

Cowburn, P. J., Cleland, J. G.F., McArthur, J. D., MacLean, M. R., McMurray, J. J.V. and Dargie, H. J. (1998) Pulmonary and systemic responses to exogenous endothelin-1 in patients with left ventricular dysfunction. Journal of Cardiovascular Pharmacology, 31(Sup 1), S290-S293. (doi: 10.1097/00005344-199800001-00081) (PMID:9595462)

Book Sections

MacLean, M.R., Church, C., MacKenzie, A., Jayasekera, G. and Mair, K. (2019) Pulmonary hypertension. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 439-447. ISBN 9783030164805 (doi:10.1007/978-3-030-16481-2_41)

Docherty, C. K., Harvey, K. Y., Mair, K. M., Griffin, S., Denver, N. and MacLean, M. R. (2018) The role of sex in the pathophysiology of pulmonary hypertension. In: Kerkhof, P. L.M. and Miller, V. M. (eds.) Sex-Specific Analysis of Cardiovascular Function. Series: Advances in experimental medicine and biology (1065). Springer: Cham, pp. 511-528. ISBN 9783319779317 (doi:10.1007/978-3-319-77932-4_31)

MacLean, M. R. and Dempsie, Y. (2010) The serotonin hypothesis of pulmonary hypertension revisited. In: Membrane Receptors, Channels and Transporters in Pulmonary Circulation. Series: Advances in experimental medicine and biology ;; v. 661, 661. Humana Press: New York, pp. 309-322. ISBN 9781607614999 (doi:10.1007/978-1-60761-500-2_20)

This list was generated on Wed Oct 20 17:33:48 2021 BST.