Miss Elaine Brown
- Technician (Cardiovascular & Metabolic Health)
Publications
2024
Bai, M. et al. (2024) Targeted degradation of zDHHC-PATs decreases substrate S -palmitoylation. PLoS ONE, 19(3), e0299665. (doi: 10.1371/journal.pone.0299665) (PMID:38512906) (PMCID:PMC10956751)
Ashford, Fiona, Kuo, Chien-Wen ORCID: https://orcid.org/0000-0002-1903-7618, Dunning, Emma, Brown, Elaine, Calagan, Sarah, Jayasinghe, Izzy, Henderson, Colin, Fuller, William
ORCID: https://orcid.org/0000-0002-5883-4433 and Wypijewski, Krzysztof
(2024)
Cysteine post-translational modifications regulate protein interactions of caveolin-3.
FASEB Journal, 38(5),
e23535.
(doi: 10.1096/fj.202201497RR)
(PMID:38466300)
Howie, J. et al. (2024) Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6. Cell Reports, 43(2), 113679. (doi: 10.1016/j.celrep.2024.113679) (PMID:38236777)
2023
Congreve, Samitha Dilini, Main, Alice, Butler, Andrew S., Gao, Xing, Brown, Elaine, Du, Chunyun, Choisy, Stephanié C., Cheng, Hongwei, Hancox, Jules C. and Fuller, William ORCID: https://orcid.org/0000-0002-5883-4433
(2023)
Palmitoylation regulates the magnitude of HCN4-mediated currents in mammalian cells.
Frontiers in Physiology, 14,
1163339.
(doi: 10.3389/fphys.2023.1163339)
(PMID:37123274)
(PMCID:PMC10133559)
2022
Gao, X. et al. (2022) Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7. Cell Calcium, 106, 102639. (doi: 10.1016/j.ceca.2022.102639) (PMID:36027648)
2020
Plain, Fiona, Howie, Jacqueline, Kennedy, Jennifer, Brown, Elaine, Shattock, Michael J., Fraser, Niall J. and Fuller, William ORCID: https://orcid.org/0000-0002-5883-4433
(2020)
Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase.
Communications Biology, 3,
411.
(doi: 10.1038/s42003-020-01145-3)
(PMID:32737405)
(PMCID:PMC7395175)
2016
Duncan, Samuel M., Myburgh, Elmarie ORCID: https://orcid.org/0000-0002-2007-5902, Philipon, Cintia, Brown, Elaine, Meissner, Markus
ORCID: https://orcid.org/0000-0002-4816-5221, Brewer, James
ORCID: https://orcid.org/0000-0001-7933-0915 and Mottram, Jeremy
ORCID: https://orcid.org/0000-0001-5574-3766
(2016)
Conditional gene deletion with DiCre demonstrates an essential role for CRK3 in Leishmania mexicana cell cycle regulation.
Molecular Microbiology, 100(6),
pp. 931-944.
(doi: 10.1111/mmi.13375)
(PMID:26991545)
(PMCID:PMC4913733)
Grewal, J. S. et al. (2016) PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast. Journal of Biological Chemistry, 291, pp. 9492-9500. (doi: 10.1074/jbc.M116.714972) (PMID:26940875) (PMCID:PMC4850289)
2015
Moss, Catherine X., Brown, Elaine, Hamilton, Alana, Van der Veken, Pieter, Augustyns, Koen and Mottram, Jeremy ORCID: https://orcid.org/0000-0001-5574-3766
(2015)
An essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma brucei.
PLoS ONE, 10(3),
e0123241.
(doi: 10.1371/journal.pone.0123241)
(PMID:25816352)
(PMCID:PMC4376731)
2014
Jones, Nathaniel G., Thomas, Elizabeth B., Brown, Elaine, Dickens, Nicholas J. ORCID: https://orcid.org/0000-0003-0492-5855, Hammarton, Tansy C.
ORCID: https://orcid.org/0000-0002-0799-6600 and Mottram, Jeremy C.
ORCID: https://orcid.org/0000-0001-5574-3766
(2014)
Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen.
PLoS Pathogens, 10(1),
e1003886.
(doi: 10.1371/journal.ppat.1003886)
2011
Munday, Jane C. ORCID: https://orcid.org/0000-0001-7792-2749, McLuskey, Karen, Brown, Elaine, Coombs, Graham H. and Mottram, Jeremy C.
ORCID: https://orcid.org/0000-0001-5574-3766
(2011)
Oligopeptidase B deficient mutants of Leishmania major.
Molecular and Biochemical Parasitology, 175(1),
pp. 49-57.
(doi: 10.1016/j.molbiopara.2010.09.003)
Walker, R.G., Thomson, G., Malone, K., Nowicki, M.W., Brown, E., Blake, D.G., Turner, N.J., Walkinshaw, M.D., Grant, K.M. and Mottram, J.C. ORCID: https://orcid.org/0000-0001-5574-3766
(2011)
High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase.
PLoS Neglected Tropical Diseases, 5(4),
e1033.
(doi: 10.1371/journal.pntd.0001033)
2010
Gomes, Felipe C., Ali, Nahla Osman M., Brown, Elaine, Walker, Roderick G., Grant, Karen M. and Mottram, Jeremy C. (2010) Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178. Molecular and Biochemical Parasitology, 171(2), pp. 89-96. (doi: 10.1016/j.molbiopara.2010.03.002)
2009
Monnerat, Séverine, Clucas, Caroline ORCID: https://orcid.org/0000-0001-5592-6810, Brown, Elaine, Mottram, Jeremy C.
ORCID: https://orcid.org/0000-0001-5574-3766 and Hammarton, Tansy C.
ORCID: https://orcid.org/0000-0002-0799-6600
(2009)
Searching for novel cell cycle regulators in Trypanosoma brucei with an RNA interference screen.
BMC Research Notes, 2(46),
(doi: 10.1186/1756-0500-2-46)
Articles
Bai, M. et al. (2024) Targeted degradation of zDHHC-PATs decreases substrate S -palmitoylation. PLoS ONE, 19(3), e0299665. (doi: 10.1371/journal.pone.0299665) (PMID:38512906) (PMCID:PMC10956751)
Ashford, Fiona, Kuo, Chien-Wen ORCID: https://orcid.org/0000-0002-1903-7618, Dunning, Emma, Brown, Elaine, Calagan, Sarah, Jayasinghe, Izzy, Henderson, Colin, Fuller, William
ORCID: https://orcid.org/0000-0002-5883-4433 and Wypijewski, Krzysztof
(2024)
Cysteine post-translational modifications regulate protein interactions of caveolin-3.
FASEB Journal, 38(5),
e23535.
(doi: 10.1096/fj.202201497RR)
(PMID:38466300)
Howie, J. et al. (2024) Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6. Cell Reports, 43(2), 113679. (doi: 10.1016/j.celrep.2024.113679) (PMID:38236777)
Congreve, Samitha Dilini, Main, Alice, Butler, Andrew S., Gao, Xing, Brown, Elaine, Du, Chunyun, Choisy, Stephanié C., Cheng, Hongwei, Hancox, Jules C. and Fuller, William ORCID: https://orcid.org/0000-0002-5883-4433
(2023)
Palmitoylation regulates the magnitude of HCN4-mediated currents in mammalian cells.
Frontiers in Physiology, 14,
1163339.
(doi: 10.3389/fphys.2023.1163339)
(PMID:37123274)
(PMCID:PMC10133559)
Gao, X. et al. (2022) Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7. Cell Calcium, 106, 102639. (doi: 10.1016/j.ceca.2022.102639) (PMID:36027648)
Plain, Fiona, Howie, Jacqueline, Kennedy, Jennifer, Brown, Elaine, Shattock, Michael J., Fraser, Niall J. and Fuller, William ORCID: https://orcid.org/0000-0002-5883-4433
(2020)
Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase.
Communications Biology, 3,
411.
(doi: 10.1038/s42003-020-01145-3)
(PMID:32737405)
(PMCID:PMC7395175)
Duncan, Samuel M., Myburgh, Elmarie ORCID: https://orcid.org/0000-0002-2007-5902, Philipon, Cintia, Brown, Elaine, Meissner, Markus
ORCID: https://orcid.org/0000-0002-4816-5221, Brewer, James
ORCID: https://orcid.org/0000-0001-7933-0915 and Mottram, Jeremy
ORCID: https://orcid.org/0000-0001-5574-3766
(2016)
Conditional gene deletion with DiCre demonstrates an essential role for CRK3 in Leishmania mexicana cell cycle regulation.
Molecular Microbiology, 100(6),
pp. 931-944.
(doi: 10.1111/mmi.13375)
(PMID:26991545)
(PMCID:PMC4913733)
Grewal, J. S. et al. (2016) PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast. Journal of Biological Chemistry, 291, pp. 9492-9500. (doi: 10.1074/jbc.M116.714972) (PMID:26940875) (PMCID:PMC4850289)
Moss, Catherine X., Brown, Elaine, Hamilton, Alana, Van der Veken, Pieter, Augustyns, Koen and Mottram, Jeremy ORCID: https://orcid.org/0000-0001-5574-3766
(2015)
An essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma brucei.
PLoS ONE, 10(3),
e0123241.
(doi: 10.1371/journal.pone.0123241)
(PMID:25816352)
(PMCID:PMC4376731)
Jones, Nathaniel G., Thomas, Elizabeth B., Brown, Elaine, Dickens, Nicholas J. ORCID: https://orcid.org/0000-0003-0492-5855, Hammarton, Tansy C.
ORCID: https://orcid.org/0000-0002-0799-6600 and Mottram, Jeremy C.
ORCID: https://orcid.org/0000-0001-5574-3766
(2014)
Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen.
PLoS Pathogens, 10(1),
e1003886.
(doi: 10.1371/journal.ppat.1003886)
Munday, Jane C. ORCID: https://orcid.org/0000-0001-7792-2749, McLuskey, Karen, Brown, Elaine, Coombs, Graham H. and Mottram, Jeremy C.
ORCID: https://orcid.org/0000-0001-5574-3766
(2011)
Oligopeptidase B deficient mutants of Leishmania major.
Molecular and Biochemical Parasitology, 175(1),
pp. 49-57.
(doi: 10.1016/j.molbiopara.2010.09.003)
Walker, R.G., Thomson, G., Malone, K., Nowicki, M.W., Brown, E., Blake, D.G., Turner, N.J., Walkinshaw, M.D., Grant, K.M. and Mottram, J.C. ORCID: https://orcid.org/0000-0001-5574-3766
(2011)
High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase.
PLoS Neglected Tropical Diseases, 5(4),
e1033.
(doi: 10.1371/journal.pntd.0001033)
Gomes, Felipe C., Ali, Nahla Osman M., Brown, Elaine, Walker, Roderick G., Grant, Karen M. and Mottram, Jeremy C. (2010) Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178. Molecular and Biochemical Parasitology, 171(2), pp. 89-96. (doi: 10.1016/j.molbiopara.2010.03.002)
Monnerat, Séverine, Clucas, Caroline ORCID: https://orcid.org/0000-0001-5592-6810, Brown, Elaine, Mottram, Jeremy C.
ORCID: https://orcid.org/0000-0001-5574-3766 and Hammarton, Tansy C.
ORCID: https://orcid.org/0000-0002-0799-6600
(2009)
Searching for novel cell cycle regulators in Trypanosoma brucei with an RNA interference screen.
BMC Research Notes, 2(46),
(doi: 10.1186/1756-0500-2-46)
Research datasets
2024
Ashford, F., Kuo, C.-W., Dunning, E., Brown, E., Calaghan, S., Jayasinghe, I., Henderson, C., Fuller, W. and Wypijewski, K. (2024) Cysteine post-translational modifications regulate protein interactions of caveolin-3. [Data Collection]