Dr Angela Bradshaw
- Honorary Lecturer (School of Cardiovascular & Metabolic Health)
email:
Angela.Bradshaw@glasgow.ac.uk
RC422 Level C4, Cardivascular & Medical Sciences, Bhf, Cardiovascular Research Centre
Publications
2022
Schwartze, J. T., Havenga, M., Bakker, W. A. M., Bradshaw, A. C. ORCID: https://orcid.org/0000-0002-3711-6547 and Nicklin, S. A.
ORCID: https://orcid.org/0000-0002-9691-6210
(2022)
Adenoviral vectors for cardiovascular gene therapy applications: a clinical and industry perspective.
Journal of Molecular Medicine, 100(6),
pp. 875-901.
(doi: 10.1007/s00109-022-02208-0)
(PMID:35606652)
(PMCID:PMC9126699)
2021
Bates, E. A. et al. (2021) In vitro and in vivo evaluation of human adenovirus type 49 as a vector for therapeutic applications. Viruses, 13(8), 1483. (doi: 10.3390/v13081483)
2019
Noonan, Jonathan, Grassia, Gianluca, MacRitchie, Neil, Garside, Paul ORCID: https://orcid.org/0000-0001-5944-0287, Guzik, Tomasz J., Bradshaw, Angela C.
ORCID: https://orcid.org/0000-0002-3711-6547 and Maffia, Pasquale
ORCID: https://orcid.org/0000-0003-3926-4225
(2019)
A novel triple-cell two-dimensional model to study immune-vascular interplay in atherosclerosis.
Frontiers in Immunology, 10,
849.
(doi: 10.3389/fimmu.2019.00849)
(PMID:31068936)
(PMCID:PMC6491724)
Low, Emma L., Baker, Andrew H. and Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547
(2019)
TGFβ, smooth muscle cells and coronary artery disease: a review.
Cellular Signalling, 53,
pp. 90-101.
(doi: 10.1016/j.cellsig.2018.09.004)
(PMID:30227237)
(PMCID:PMC6293316)
Schwartze, Julian Tristan, Low, Emma Louise and Bradshaw, Angela Claire ORCID: https://orcid.org/0000-0002-3711-6547
(2019)
TGF-β in vascular pathobiology.
In: Touyz, Rhian M. and Delles, Christian (eds.)
Textbook of Vascular Medicine.
Springer: Cham, pp. 137-148.
ISBN 9783030164805
(doi: 10.1007/978-3-030-16481-2_13)
2018
Uusi-Kerttula, H. et al. (2018) Ad5NULL-A20: a tropism-modified, αvβ6 integrin-selective oncolytic adenovirus for epithelial ovarian cancer therapies. Clinical Cancer Research, 24(17), pp. 4215-4224. (doi: 10.1158/1078-0432.CCR-18-1089) (PMID:29798908)
Noonan, J. et al. (2018) In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy. Theranostics, 8(22), pp. 6195-6209. (doi: 10.7150/thno.28665) (PMID:30613292) (PMCID:PMC6299693)
2017
Lopez-Gordo, Estrella, Doszpoly, Andor, Duffy, Margaret R., Coughlan, Lynda, Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547, White, Katie M., Denby, Laura, Nicklin, Stuart A.
ORCID: https://orcid.org/0000-0002-9691-6210 and Baker, Andrew H.
(2017)
Defining a novel role for the coxsackie and adenovirus receptor in human adenovirus serotype 5 transduction in vitro in the presence of mouse serum.
Journal of Virology, 91(12),
e02487-16.
(doi: 10.1128/JVI.02487-16)
(PMID:28381574)
(PMCID:PMC5446653)
Deng, Lin, Baker, Andrew H. and Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547
(2017)
MicroRNA delivery strategies to the lung in a model of pulmonary hypertension.
In: Ishikawa, Kiyotake (ed.)
Cardiac Gene Therapy: Methods and Protocols.
Series: Methods in molecular biology (1521).
Humana Press: New York, NY, pp. 325-338.
ISBN 9781493965861
(doi: 10.1007/978-1-4939-6588-5_23)
2016
Deng, Lin, Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547 and Baker, Andrew H.
(2016)
Role of noncoding RNA in vascular remodelling.
Current Opinion in Lipidology, 27(5),
pp. 439-448.
(doi: 10.1097/MOL.0000000000000336)
(PMID:27472407)
2015
Deng, L. et al. (2015) MicroRNA-143 activation regulates smooth muscle and endothelial cell crosstalk in pulmonary arterial hypertension. Circulation Research, 117(10), pp. 870-883. (doi: 10.1161/CIRCRESAHA.115.306806) (PMID:26311719) (PMCID:PMC4620852)
2013
Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547 and Baker, Andrew H.
(2013)
Gene therapy for cardiovascular disease: perspectives and potential.
Vascular Pharmacology, 58(3),
pp. 174-181.
(doi: 10.1016/j.vph.2012.10.008)
Parker, Alan L., Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547, Alba, Raul, Nicklin, Stuart A.
ORCID: https://orcid.org/0000-0002-9691-6210 and Baker, Andrew H.
(2013)
Capsid modification strategies for detargeting adenoviral vectors.
In: Chillon, M. and Bosch, A. (eds.)
Adenovirus: Methods and Protocols [3rd.].
Series: Methods in molecular biology (1089).
Humana Press, pp. 45-59.
ISBN 9781627036788
(doi: 10.1007/978-1-62703-679-5_3)
White, Katie M., Alba, Raul, Parker, Alan L., Wright, Audrey F., Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547, Delles, Christian
ORCID: https://orcid.org/0000-0003-2238-2612, McDonald, Robert A. and Baker, Andrew H.
(2013)
Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile.
Journal of Cardiothoracic Surgery, 8(183),
(doi: 10.1186/1749-8090-8-183)
2012
Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547, Coughlan, Lynda, Miller, Ashley M.., Nicklin, Stuart A.
ORCID: https://orcid.org/0000-0002-9691-6210, Baker, Andrew H., Alba, Raul and van Rooijen, Nico
(2012)
Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses.
Journal of Controlled Release, 164(3),
pp. 394-402.
(doi: 10.1016/j.jconrel.2012.05.025)
Coughlan, L. et al. (2012) Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery. Molecular Therapy, 20(12), pp. 2268-2281. (doi: 10.1038/mt.2012.162) (PMID:22929662) (PMCID:PMC3514487)
Duffy, Margaret R., Parker, Alan L., Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547 and Baker, Andrew H.
(2012)
Manipulation of adenovirus interactions with host factors for gene therapy applications.
Nanomedicine, 7(2),
pp. 271-288.
(doi: 10.2217/nnm.11.186)
Alba, R., Bradshaw, A.C. ORCID: https://orcid.org/0000-0002-3711-6547, Mestre-Francés, N., Verdier, J.-M., Henaff, D. and Baker, A.H.
(2012)
Coagulation factor X mediates adenovirus type 5 liver gene transfer in non-human primates (Microcebus murinus).
Gene Therapy, 19(1),
pp. 109-113.
(doi: 10.1038/gt.2011.87)
2011
Duffy, M.R., Bradshaw, A.C. ORCID: https://orcid.org/0000-0002-3711-6547, Parker, A.L., McVey, J.H. and Baker, A.H.
(2011)
A cluster of basic amino acids in the factor X serine protease mediate surface attachment of adenovirus/FX complexes.
Journal of Virology, 85(20),
pp. 10914-10919.
(doi: 10.1128/JVI.05382-11)
2010
Alba, R. et al. (2010) Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors. Blood, 14(116), pp. 2656-2664. (doi: 10.1182/blood-2009-12-260026)
Bradshaw, A.C. ORCID: https://orcid.org/0000-0002-3711-6547, Parker, A.L., Duffy, M.R., Coughlan, L., van Rooijen, N., Kahari, V.M., Nicklin, S.A.
ORCID: https://orcid.org/0000-0002-9691-6210 and Baker, A.H.
(2010)
Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X.
PLoS Pathogens, 6(10),
e1001142.
(doi: 10.1371/journal.ppat.1001142)
Coughlan, L., Alba, R., Parker, A.L., Bradshaw, A.C. ORCID: https://orcid.org/0000-0002-3711-6547, Mcneish, I.A.
ORCID: https://orcid.org/0000-0002-9387-7586, Nicklin, S.
ORCID: https://orcid.org/0000-0002-9691-6210 and Baker, A.
(2010)
Tropism-modification strategies for targeted gene delivery using adenoviral vectors.
Viruses, 2(10),
pp. 2290-2355.
(doi: 10.3390/v2102290)
(PMID:21994621)
(PMCID:PMC3185574)
2009
Alba, R. et al. (2009) Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer. Blood, 114(5), pp. 965-971. (doi: 10.1182/blood-2009-03-208835)
Articles
Schwartze, J. T., Havenga, M., Bakker, W. A. M., Bradshaw, A. C. ORCID: https://orcid.org/0000-0002-3711-6547 and Nicklin, S. A.
ORCID: https://orcid.org/0000-0002-9691-6210
(2022)
Adenoviral vectors for cardiovascular gene therapy applications: a clinical and industry perspective.
Journal of Molecular Medicine, 100(6),
pp. 875-901.
(doi: 10.1007/s00109-022-02208-0)
(PMID:35606652)
(PMCID:PMC9126699)
Bates, E. A. et al. (2021) In vitro and in vivo evaluation of human adenovirus type 49 as a vector for therapeutic applications. Viruses, 13(8), 1483. (doi: 10.3390/v13081483)
Noonan, Jonathan, Grassia, Gianluca, MacRitchie, Neil, Garside, Paul ORCID: https://orcid.org/0000-0001-5944-0287, Guzik, Tomasz J., Bradshaw, Angela C.
ORCID: https://orcid.org/0000-0002-3711-6547 and Maffia, Pasquale
ORCID: https://orcid.org/0000-0003-3926-4225
(2019)
A novel triple-cell two-dimensional model to study immune-vascular interplay in atherosclerosis.
Frontiers in Immunology, 10,
849.
(doi: 10.3389/fimmu.2019.00849)
(PMID:31068936)
(PMCID:PMC6491724)
Low, Emma L., Baker, Andrew H. and Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547
(2019)
TGFβ, smooth muscle cells and coronary artery disease: a review.
Cellular Signalling, 53,
pp. 90-101.
(doi: 10.1016/j.cellsig.2018.09.004)
(PMID:30227237)
(PMCID:PMC6293316)
Uusi-Kerttula, H. et al. (2018) Ad5NULL-A20: a tropism-modified, αvβ6 integrin-selective oncolytic adenovirus for epithelial ovarian cancer therapies. Clinical Cancer Research, 24(17), pp. 4215-4224. (doi: 10.1158/1078-0432.CCR-18-1089) (PMID:29798908)
Noonan, J. et al. (2018) In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy. Theranostics, 8(22), pp. 6195-6209. (doi: 10.7150/thno.28665) (PMID:30613292) (PMCID:PMC6299693)
Lopez-Gordo, Estrella, Doszpoly, Andor, Duffy, Margaret R., Coughlan, Lynda, Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547, White, Katie M., Denby, Laura, Nicklin, Stuart A.
ORCID: https://orcid.org/0000-0002-9691-6210 and Baker, Andrew H.
(2017)
Defining a novel role for the coxsackie and adenovirus receptor in human adenovirus serotype 5 transduction in vitro in the presence of mouse serum.
Journal of Virology, 91(12),
e02487-16.
(doi: 10.1128/JVI.02487-16)
(PMID:28381574)
(PMCID:PMC5446653)
Deng, Lin, Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547 and Baker, Andrew H.
(2016)
Role of noncoding RNA in vascular remodelling.
Current Opinion in Lipidology, 27(5),
pp. 439-448.
(doi: 10.1097/MOL.0000000000000336)
(PMID:27472407)
Deng, L. et al. (2015) MicroRNA-143 activation regulates smooth muscle and endothelial cell crosstalk in pulmonary arterial hypertension. Circulation Research, 117(10), pp. 870-883. (doi: 10.1161/CIRCRESAHA.115.306806) (PMID:26311719) (PMCID:PMC4620852)
Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547 and Baker, Andrew H.
(2013)
Gene therapy for cardiovascular disease: perspectives and potential.
Vascular Pharmacology, 58(3),
pp. 174-181.
(doi: 10.1016/j.vph.2012.10.008)
White, Katie M., Alba, Raul, Parker, Alan L., Wright, Audrey F., Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547, Delles, Christian
ORCID: https://orcid.org/0000-0003-2238-2612, McDonald, Robert A. and Baker, Andrew H.
(2013)
Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile.
Journal of Cardiothoracic Surgery, 8(183),
(doi: 10.1186/1749-8090-8-183)
Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547, Coughlan, Lynda, Miller, Ashley M.., Nicklin, Stuart A.
ORCID: https://orcid.org/0000-0002-9691-6210, Baker, Andrew H., Alba, Raul and van Rooijen, Nico
(2012)
Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses.
Journal of Controlled Release, 164(3),
pp. 394-402.
(doi: 10.1016/j.jconrel.2012.05.025)
Coughlan, L. et al. (2012) Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery. Molecular Therapy, 20(12), pp. 2268-2281. (doi: 10.1038/mt.2012.162) (PMID:22929662) (PMCID:PMC3514487)
Duffy, Margaret R., Parker, Alan L., Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547 and Baker, Andrew H.
(2012)
Manipulation of adenovirus interactions with host factors for gene therapy applications.
Nanomedicine, 7(2),
pp. 271-288.
(doi: 10.2217/nnm.11.186)
Alba, R., Bradshaw, A.C. ORCID: https://orcid.org/0000-0002-3711-6547, Mestre-Francés, N., Verdier, J.-M., Henaff, D. and Baker, A.H.
(2012)
Coagulation factor X mediates adenovirus type 5 liver gene transfer in non-human primates (Microcebus murinus).
Gene Therapy, 19(1),
pp. 109-113.
(doi: 10.1038/gt.2011.87)
Duffy, M.R., Bradshaw, A.C. ORCID: https://orcid.org/0000-0002-3711-6547, Parker, A.L., McVey, J.H. and Baker, A.H.
(2011)
A cluster of basic amino acids in the factor X serine protease mediate surface attachment of adenovirus/FX complexes.
Journal of Virology, 85(20),
pp. 10914-10919.
(doi: 10.1128/JVI.05382-11)
Alba, R. et al. (2010) Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors. Blood, 14(116), pp. 2656-2664. (doi: 10.1182/blood-2009-12-260026)
Bradshaw, A.C. ORCID: https://orcid.org/0000-0002-3711-6547, Parker, A.L., Duffy, M.R., Coughlan, L., van Rooijen, N., Kahari, V.M., Nicklin, S.A.
ORCID: https://orcid.org/0000-0002-9691-6210 and Baker, A.H.
(2010)
Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X.
PLoS Pathogens, 6(10),
e1001142.
(doi: 10.1371/journal.ppat.1001142)
Coughlan, L., Alba, R., Parker, A.L., Bradshaw, A.C. ORCID: https://orcid.org/0000-0002-3711-6547, Mcneish, I.A.
ORCID: https://orcid.org/0000-0002-9387-7586, Nicklin, S.
ORCID: https://orcid.org/0000-0002-9691-6210 and Baker, A.
(2010)
Tropism-modification strategies for targeted gene delivery using adenoviral vectors.
Viruses, 2(10),
pp. 2290-2355.
(doi: 10.3390/v2102290)
(PMID:21994621)
(PMCID:PMC3185574)
Alba, R. et al. (2009) Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer. Blood, 114(5), pp. 965-971. (doi: 10.1182/blood-2009-03-208835)
Book Sections
Schwartze, Julian Tristan, Low, Emma Louise and Bradshaw, Angela Claire ORCID: https://orcid.org/0000-0002-3711-6547
(2019)
TGF-β in vascular pathobiology.
In: Touyz, Rhian M. and Delles, Christian (eds.)
Textbook of Vascular Medicine.
Springer: Cham, pp. 137-148.
ISBN 9783030164805
(doi: 10.1007/978-3-030-16481-2_13)
Deng, Lin, Baker, Andrew H. and Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547
(2017)
MicroRNA delivery strategies to the lung in a model of pulmonary hypertension.
In: Ishikawa, Kiyotake (ed.)
Cardiac Gene Therapy: Methods and Protocols.
Series: Methods in molecular biology (1521).
Humana Press: New York, NY, pp. 325-338.
ISBN 9781493965861
(doi: 10.1007/978-1-4939-6588-5_23)
Parker, Alan L., Bradshaw, Angela C. ORCID: https://orcid.org/0000-0002-3711-6547, Alba, Raul, Nicklin, Stuart A.
ORCID: https://orcid.org/0000-0002-9691-6210 and Baker, Andrew H.
(2013)
Capsid modification strategies for detargeting adenoviral vectors.
In: Chillon, M. and Bosch, A. (eds.)
Adenovirus: Methods and Protocols [3rd.].
Series: Methods in molecular biology (1089).
Humana Press, pp. 45-59.
ISBN 9781627036788
(doi: 10.1007/978-1-62703-679-5_3)