Dr Bill Mullen

Senior Research Fellow (Cardiovascular & Metabolic Health)

telephone: 01413306210
email: William.Mullen@glasgow.ac.uk

Room B2.21, Proteomics and Systems Medicine, Joseph Black Building, Glasgow G12 8QQ, Uk, G12 8QQ

Biography

Bill Mullen is a senior Research Fellow for the School of Cardiovascular and Metabolic Health at the University of Glasgow. In 2014 his work was ranked in the top 1% for citations in his field of research by Thompson Reuters, which earned him the title of a highly cited research. He returned to the University after working in a Pharmaceutical Drug Metabolism lab and also running his own company designing and manufacturing scientific instruments for metabolite analysis. Since returning to the University in 1998 he has published more than 100 manuscripts in peer reviewed journals. His first 10 years back at the University was in the Plant Products and Human Nutrition group, where his expertise in mass spectrometric analysis became world renowned.

Research interests

Dr Mullen's principle aim was to find causal links between diet and health. We all know that a diet rich in fruit and vegetables is good for us, but how can we provide hard evidence of this. It became apparent to him that the classical approaches to this question, using conventional markers of health, was not going to reveal an answer. The chance to collaborate with Harald Mischak in applied systems biology, with the latest mass spectrometric systems, was too good an offer to turn down. Although the primary goal of the group is generating clinically applicable biomarkers of a range of chronic diseases, the high specificity and sensitivity for these diseases would make them an ideal method to answer his original goal of providing evidence of the beneficial effect of a healthy lifestyle. By being able to determine biomarkers of specific diseases at such an early stage, that no lasting damage had incurred, he believes it may be possible to show how changes in diet could alter the biomarker scoring from unhealthy to healthy. Recent work has provided excellent evidence for the use of this clinical technology in health and nutrition research. His publication in the American Journal of Clinical Nutrition has shown the supplementation of the diet with 20 ml of olive oil, either refined or virgin olive oil can markedly improved the coronary artery disease biomarker score in healthy adults. This opens up a new use for the clinical biomarker technology as means of testing the "heart health" claims of so called bioactive foods and ingredients.

Publications

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Jump to: 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006

Number of items: 136.

2025

Parveen, Humaira, Boder, Philipp, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Graham, Delyth ORCID: https://orcid.org/0000-0002-7328-4708, Van Agtmael, Tom ORCID: https://orcid.org/0000-0003-4282-449X, Rampoldi, Luca, Delles, Christian ORCID: https://orcid.org/0000-0003-2238-2612 and Mary, Sheon ORCID: https://orcid.org/0000-0001-9392-3020 (2025) Early renal response to long term salt loading: Mitochondrial dysfunction, ER stress and uromodulin accumulation in the kidney medulla. American Journal of Physiology: Renal Physiology, (Accepted for Publication)

Kuo, C.-W. et al. (2025) Nanobody-thioesterase chimeras to specifically target protein palmitoylation. Nature Communications, 16(1), 1445. (doi: 10.1038/s41467-025-56716-x) (PMID:39920166) (PMCID:PMC11805987)

2024

Catanese, L. et al. (2024) Differentiating primary and secondary FSGS using non-invasive urine biomarkers. Clinical Kidney Journal, 17(2), sfad296. (doi: 10.1093/ckj/sfad296) (PMID:38313685) (PMCID:PMC10833144)

2023

de Beer, Dalene, MC. Mels, Catharina, Schutte, Aletta, Delles, Christian ORCID: https://orcid.org/0000-0003-2238-2612, Mary, Sheon ORCID: https://orcid.org/0000-0001-9392-3020, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Mischak, Harald and Kruger, Ruan (2023) Urinary peptidomics and pulse wave velocity: The African-PREDICT study. Journal of Proteome Research, 22(10), pp. 3282-3289. (doi: 10.1021/acs.jproteome.3c00347) (PMID:37688558) (PMCID:PMC10563154)

De Beer, Dalene, Mels, Catharina M.C., Schutte, Aletta E., Delles, Christian ORCID: https://orcid.org/0000-0003-2238-2612, Mary, Sheon ORCID: https://orcid.org/0000-0001-9392-3020, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Latosinska, Agnieszka, Mischak, Harald and Kruger, Ruan (2023) Identifying a urinary peptidomics profile for hypertension in young adults: the African-PREDICT study. Proteomics, 23(11), 2200444. (doi: 10.1002/pmic.202200444) (PMID:36943111)

Adam, Sebastian, Zheng, Dazhong, Klein, Andreas, Volz, Carsten, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Shirran, Sally L., Smith, Brian O. ORCID: https://orcid.org/0000-0003-3363-4168, Kalinina, Olga V., Müller, Rolf and Koehnke, Jesko ORCID: https://orcid.org/0000-0002-7153-1365 (2023) Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis. Nature Chemistry, 15(4), pp. 560-568. (doi: 10.1038/s41557-023-01153-w) (PMID:36894702) (PMCID:PMC10070186)

de Beer, Dalene, Mels, Catharina M. C., Schutte, Aletta E., Delles, Christian ORCID: https://orcid.org/0000-0003-2238-2612, Mary, Sheon ORCID: https://orcid.org/0000-0001-9392-3020, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Mischak, Harald and Kruger, Ruan (2023) A urinary peptidomics approach for early stages of cardiovascular disease risk: the African-PREDICT study. Hypertension Research, 46(2), pp. 485-494. (doi: 10.1038/s41440-022-01097-7) (PMID:36396816)

2022

Frantzi, M. et al. (2022) Validation of diagnostic nomograms based on CE-MS urinary biomarkers to detect clinically significant prostate cancer. World Journal of Urology, 40(9), pp. 2195-2203. (doi: 10.1007/s00345-022-04077-1) (PMID:35841414)

Nicol, Katie, Mansoorian, Bahareh, Latosinska, Agnieszka, Koutroulaki, Aimilia, Mullen, Bill ORCID: https://orcid.org/0000-0002-5685-1563 and Combet, Emilie ORCID: https://orcid.org/0000-0002-9302-8971 (2022) No evidence of differential impact of sunflower and rapeseed oil on biomarkers of coronary artery disease or chronic kidney disease in healthy adults with overweight and obesity: result from a randomised control trial. European Journal of Nutrition, 61(6), pp. 3119-3133. (doi: 10.1007/s00394-022-02810-5) (PMID:35381848) (PMCID:PMC9363295)

O’Connell, S. P. et al. (2022) A model to detect significant prostate cancer integrating urinary peptide and extracellular vesicle RNA data. Cancers, 14(8), 1995. (doi: 10.3390/cancers14081995) (PMID:35454901) (PMCID:PMC9027643)

2021

He, T. et al. (2021) Urinary peptides in heart failure: a link to molecular pathophysiology. European Journal of Heart Failure, 23(11), pp. 1875-1887. (doi: 10.1002/ejhf.2195) (PMID:33881206)

Mary, Sheon ORCID: https://orcid.org/0000-0001-9392-3020, Small, Heather, Herse, Florian, Carrick, Emma, Flynn, Arun, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Dechend, Ralf and Delles, Christian ORCID: https://orcid.org/0000-0003-2238-2612 (2021) Pre-existing hypertension and pregnancy induced hypertension reveal molecular differences in placental proteome in rodents. Physiological Genomics, 53(6), pp. 259-268. (doi: 10.1152/physiolgenomics.00160.2020) (PMID:33969702)

2020

Latosinska, Agnieszka, Davalieva, Katarina, Makridakis, Manousos, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Schanstra, Joost P., Vlahou, Antonia, Mischak, Harald and Frantzi, Maria (2020) Molecular changes in tissue proteome during prostate cancer development: proof-of-principle investigation. Diagnostics, 10(9), 655. (doi: 10.3390/diagnostics10090655) (PMID:32878211)

Havlik, Jaroslav ORCID: https://orcid.org/0000-0003-1900-0951, Marinello, Vittoria, Gardyne, Andrew, Hou, Min, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Morrison, Douglas J. ORCID: https://orcid.org/0000-0002-4161-5699, Preston, Thomas ORCID: https://orcid.org/0000-0002-9900-5682, Combet, Emilie ORCID: https://orcid.org/0000-0002-9302-8971 and Edwards, Christine A. ORCID: https://orcid.org/0000-0003-0406-918X (2020) Dietary fibres differentially impact on the production of phenolic acids from rutin in an in vitro fermentation model of the human gut microbiota. Nutrients, 12(6), 1577. (doi: 10.3390/nu12061577) (PMID:32481553) (PMCID:PMC7352394)

He, Tianlin, Siwy, Justyna, Metzger, Jochen, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Mischak, Harald, Schanstra, Joost P., Zürbig, Petra and Jankowski, Vera (2020) Associations of urinary polymeric immunoglobulin receptor peptides in the context of cardio-renal syndrome. Scientific Reports, 10, 8291. (doi: 10.1038/s41598-020-65154-2) (PMID:32427855) (PMCID:PMC7237418)

2019

Schanstra, J. P. et al. (2019) Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment. JCI Insight, 4(10), e125638. (doi: 10.1172/jci.insight.125638)

Lucas-Herald, Angela K. ORCID: https://orcid.org/0000-0003-2662-1684, Zürbig, Petra, Mason, Avril, Kinning, Esther, Brown, Catriona E., Mansoorian, Bahareh, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Ahmed, Syed Faisal ORCID: https://orcid.org/0000-0003-0689-5549 and Delles, Christian ORCID: https://orcid.org/0000-0003-2238-2612 (2019) Proteomic evidence of biological aging in a child with a compound heterozygous ZMPSTE24 mutation. Proteomics Clinical Applications, 13(2), 1800135. (doi: 10.1002/prca.201800135) (PMID:30548811) (PMCID:PMC6492098)

2018

Salin, Karine, Villasevil, Eugenia M., Anderson, Graeme J., Auer, Sonya K., Selman, Colin ORCID: https://orcid.org/0000-0002-8727-0593, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Chinopoulos, Christos and Metcalfe, Neil B. ORCID: https://orcid.org/0000-0002-1970-9349 (2018) Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost. Functional Ecology, 32(9), pp. 2149-2157. (doi: 10.1111/1365-2435.13125) (PMID:30333678) (PMCID:PMC6175143)

Lygirou, Vasiliki, Latosinska, Agnieszka, Makridakis, Manousos, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Delles, Christian ORCID: https://orcid.org/0000-0003-2238-2612, Schanstra, Joost P., Zoidakis, Jerome, Pieske, Burkert, Mischak, Harald and Vlahou, Antonia (2018) Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease. Journal of Translational Medicine, 16(1), 104. (doi: 10.1186/s12967-018-1476-9) (PMID:29665821) (PMCID:PMC5905170)

Currie, G. E. et al. (2018) Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria. Cardiovascular Diabetology, 17, 50. (doi: 10.1186/s12933-018-0697-9) (PMID:29625564) (PMCID:PMC5889591)

Liu, Y. et al. (2018) Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease. Scientific Reports, 8, 5584. (doi: 10.1038/s41598-018-22938-x) (PMID:29615724) (PMCID:PMC5882886)

Southall, June ORCID: https://orcid.org/0000-0002-5496-1531, Henry, Sarah L., Gardiner, Alastair T., Roszak, Aleksander W., Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Carey, Anne-Marie, Kelly, Sharon M. ORCID: https://orcid.org/0000-0002-3516-1387, de Percin Northumberland, Claire Ortmann and Cogdell, Richard J. ORCID: https://orcid.org/0000-0003-2119-6607 (2018) Characterisation of a pucBA deletion mutant from Rhodopseudomonas palustris lacking all but the pucBAd genes. Photosynthesis Research, 135(1-3), pp. 9-21. (doi: 10.1007/s11120-017-0386-7) (PMID:28567613)

Williams, Jamie J.L., Al-Otaiq, Nasser, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Burchmore, Richard ORCID: https://orcid.org/0000-0003-1663-9004, Liu, Libin, Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316, Schaper, Fred, Pilch, Paul F. and Palmer, Timothy M. (2018) Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nature Communications, 9, 168. (doi: 10.1038/s41467-017-02585-y) (PMID:29330478) (PMCID:PMC5766592)

Pejchinovski, M., Siwy, J., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Mischak, H., Petri, M.A., Burkly, L.C. and Wei, R. (2018) Urine peptidomic biomarkers for diagnosis of patients with systematic lupus erythematosus. Lupus, 27(1), pp. 6-16. (doi: 10.1177/0961203317707827) (PMID:28474961)

Silva, Sandra, Garcia-Aloy, Mar, Eduardo Figueira, Maria, Combet, Emilie ORCID: https://orcid.org/0000-0002-9302-8971, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563 and Rosário Bronze, Maria (2018) High resolution mass spectrometric analysis of secoiridoids and metabolites as biomarkers of acute olive oil intake – an approach to study inter-individual variability in humans. Molecular Nutrition and Food Research, 62(2), 1700065. (doi: 10.1002/mnfr.201700065) (PMID:29068138)

2017

Magalhães, P. et al. (2017) Association of kidney fibrosis with urinary peptides: a path towards non-invasive liquid biopsies? Scientific Reports, 7, 16915. (doi: 10.1038/s41598-017-17083-w) (PMID:29208969) (PMCID:PMC5717105)

Edwards, C.A. ORCID: https://orcid.org/0000-0003-0406-918X, Havlik, J. ORCID: https://orcid.org/0000-0003-1900-0951, Cong, W. ORCID: https://orcid.org/0000-0002-5034-8182, Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Preston, T. ORCID: https://orcid.org/0000-0002-9900-5682, Morrison, D.J. ORCID: https://orcid.org/0000-0002-4161-5699 and Combet, E. ORCID: https://orcid.org/0000-0002-9302-8971 (2017) Polyphenols and health: Interactions between fibre, plant polyphenols and the gut microbiota. Nutrition Bulletin, 42(4), pp. 356-360. (doi: 10.1111/nbu.12296) (PMID:29200959) (PMCID:PMC5698720)

Siwy, J. et al. (2017) Noninvasive diagnosis of chronic kidney diseases using urinary proteome analysis. Nephrology Dialysis Transplantation, 12(1), pp. 2079-2089. (doi: 10.1093/ndt/gfw337) (PMID:27984204)

Pontillo, C. et al. (2017) Prediction of chronic kidney disease stage 3 by CKD273, a urinary proteomic biomarker. Kidney International Reports, 2(6), pp. 1066-1075. (doi: 10.1016/j.ekir.2017.06.004) (PMID:29130072) (PMCID:PMC5669285)

Torati, Lucas S., Migaud, Hervé, Doherty, Mary K., Siwy, Justyna, Mullen, Willian ORCID: https://orcid.org/0000-0002-5685-1563, Mesquita, Pedro E.C. and Albalat, Amaya (2017) Comparative proteome and peptidome analysis of the cephalic fluid secreted by Arapaima gigas (Teleostei: Osteoglossidae) during and outside parental care. PLoS ONE, 12(10), e0186692. (doi: 10.1371/journal.pone.0186692) (PMID:29065179) (PMCID:PMC5655490)

Latosinska, A. et al. (2017) Proteomics analysis of bladder cancer invasion: targeting EIF3D for therapeutic intervention. Oncotarget, 8(41), pp. 69435-69455. (doi: 10.18632/oncotarget.17279) (PMID:28488575)

Mary, Sheon ORCID: https://orcid.org/0000-0001-9392-3020, Small, Heather Yvonne, Siwy, Justyna, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Giri, Ashok and Delles, Christian ORCID: https://orcid.org/0000-0003-2238-2612 (2017) Polymerization-incompetent uromodulin in the pregnant stroke-prone spontaneously hypertensive rat. Hypertension, 69(5), pp. 910-918. (doi: 10.1161/HYPERTENSIONAHA.116.08826) (PMID:28348009) (PMCID:PMC5389592)

Ortiz, A. et al. (2017) Mitogen-activated protein kinase 14 promotes AKI. Journal of the American Society of Nephrology, 28(3), pp. 823-836. (doi: 10.1681/ASN.2015080898) (PMID:27620989)

Weissinger, E.M. et al. (2017) The proteome pattern cGvHD_MS14 allows early and accurate prediction of chronic GvHD after allogeneic stem cell transplantation. Leukemia, 31(3), pp. 654-662. (doi: 10.1038/leu.2016.259) (PMID:27677743)

Albalat, Amaya, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Husi, Holger and Mischak, Harald (2017) Tissue proteomics in vascular disease. In: Touyz, Rhian M. and Schiffrin, Ernesto L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer New York: New York, pp. 53-60. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_4)

Salin, Karine, Auer, Sonya K., Villasevil, Eugenia M., Anderson, Graeme J., Cairns, Andrew G., Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405 and Metcalfe, Neil B. ORCID: https://orcid.org/0000-0002-1970-9349 (2017) Using the MitoB method to assess levels of reactive oxygen species in ecological studies of oxidative stress. Scientific Reports, 7, 41228. (doi: 10.1038/srep41228) (PMID:28117373) (PMCID:PMC5259740)

Siebert, Stefan ORCID: https://orcid.org/0000-0002-1802-7311, Porter, Duncan, Paterson, Caron, Hampson, Rosie, Gaya, Daniel, Latosinska, Agnieszka, Mischak, Harald, Schanstra, Joost, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563 and McInnes, Iain ORCID: https://orcid.org/0000-0002-6462-4280 (2017) Urinary proteomics can define distinct diagnostic inflammatory arthritis subgroups. Scientific Reports, 7, 40473. (doi: 10.1038/srep40473) (PMID:28091549) (PMCID:PMC5320079)

2016

Martin-Pozuelo, Gala, Gonzalez-Barrio, Rocio, Barberá, Gonzalo G., Albalat, Amaya, García-Alonso, Javier, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Mischak, Harald and Periag, María Jesús (2016) Tomato Juice consumption modifies the urinary peptide profile in Sprague-Dawley rats with induced hepatic steatosis. International Journal of Molecular Sciences, 17(11), 1789. (doi: 10.3390/ijms17111789)

Thomas, Funmilola, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Tassi, Riccardo, Ramírez-Torres, Adela, Mudaliar, Manikhandan ORCID: https://orcid.org/0000-0003-1482-840X, Mcneilly, Tom, Zadoks, Ruth ORCID: https://orcid.org/0000-0002-1164-8000, Burchmore, Richard ORCID: https://orcid.org/0000-0003-1663-9004 and Eckersall, Peter ORCID: https://orcid.org/0000-0001-5254-5502 (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 1. High abundance proteins, acute phase proteins and peptidomics. Molecular BioSystems, 12(9), pp. 2735-2747. (doi: 10.1039/C6MB00239K) (PMID:27412456) (PMCID:PMC5048397)

Frantzi, M. et al. (2016) Development and validation of urine-based peptide biomarker panels for detecting bladder cancer in a multi-center study. Clinical Cancer Research, 22(16), pp. 4077-4086. (doi: 10.1158/1078-0432.CCR-15-2715) (PMID:27026199)

Schönemeier, B. et al. (2016) Urinary peptide analysis differentiates pancreatic cancer from chronic pancreatitis. Pancreas, 45(7), pp. 1018-1026. (doi: 10.1097/mpa.0000000000000573) (PMID:26784907)

Carrick, E. et al. (2016) Development of a MALDI MS-based platform for early detection of acute kidney injury. Proteomics Clinical Applications, 10(7), pp. 732-742. (doi: 10.1002/prca.201500117) (PMID:27119821) (PMCID:PMC4950042)

Farmakis, Dimitrios, Koeck, Thomas, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Parissis, John, Gogas, Bill D., Nikolaou, Maria, Lekakis, John, Mischak, Harald and Filippatos, Gerasimos (2016) Urine proteome analysis in heart failure with reduced ejection fraction complicated by chronic kidney disease: feasibility, and clinical and pathogenetic correlates. European Journal of Heart Failure, 18(7), pp. 822-829. (doi: 10.1002/ejhf.544) (PMID:27220540)

Reich, M. et al. (2016) Proteomic analysis of vitreous humor in retinal vein occlusion. PLoS ONE, 11(6), e0158001. (doi: 10.1371/journal.pone.0158001) (PMID:27362861) (PMCID:PMC4928959)

Bitsika, Vasiliki, Duveau, Venceslas, Simon-Areces, Julia, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Roucard, Corinne, Makridakis, Manousos, Mermelekas, George, Savvopoulos, Pantelis, Depaulis, Antoine and Vlahou, Antonia (2016) High-throughput LC-MS/MS proteomic analysis of a mouse model of mesiotemporal lobe epilepsy predicts microglial activation underlying disease development. Journal of Proteome Research, 15(5), pp. 1546-1562. (doi: 10.1021/acs.jproteome.6b00003) (PMID:27057777)

Latosinska, A. et al. (2016) Integrative analysis of extracellular and intracellular bladder cancer cell line proteome with transcriptome: improving coverage and validity of -omics findings. Scientific Reports, 6, 25619. (doi: 10.1038/srep25619) (PMID:27167498) (PMCID:PMC4863247)

Mullan, Adam, Delles, Christian ORCID: https://orcid.org/0000-0003-2238-2612, Ferrell, William, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Edwards, Christine A. ORCID: https://orcid.org/0000-0003-0406-918X, McColl, John H. ORCID: https://orcid.org/0000-0002-6008-2349, Roberts, Susan A. and Lean, Mike ORCID: https://orcid.org/0000-0003-2216-0083 (2016) Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized trial. Atherosclerosis, 246, pp. 169-176. (doi: 10.1016/j.atherosclerosis.2016.01.004) (PMID:26797134)

Metzger, Jochen, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Husi, Holger, Stalmach, Angelique ORCID: https://orcid.org/0000-0003-4491-654X, Herget-Rosenthal, Stefan, Groesdonk, Heiner, Mischak, Harald and Klingele, Matthias (2016) Acute kidney injury prediction in cardiac surgery patients by a urinary peptide pattern: a case-control validation study. Critical Care, 20, 157. (doi: 10.1186/s13054-016-1344-z) (PMID:27230659) (PMCID:PMC4882859)

2015

Caldwell, Stuart T. ORCID: https://orcid.org/0000-0003-1604-3462, Cairns, Andrew G., Olson, Marnie, Chalmers, Susan, Sandison, Mairi, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, McCarron, John G. and Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405 (2015) Synthesis of an azido-tagged low affinity ratiometric calcium sensor. Tetrahedron, 71(51), pp. 9571-9578. (doi: 10.1016/j.tet.2015.10.052) (PMID:26709317) (PMCID:PMC4660056)

Glorieux, G. et al. (2015) New insights in molecular mechanisms involved in chronic kidney disease using high-resolution plasma proteome analysis. Nephrology Dialysis Transplantation, 30(11), pp. 1842-1852. (doi: 10.1093/ndt/gfv254) (PMID:26160894)

Salin, Karine, Auer, Sonya k., Rudolf, Agata M., Anderson, Graeme J., Cairns, Andrew G., Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405, Selman, Colin ORCID: https://orcid.org/0000-0002-8727-0593 and Metcalfe, Neil B. ORCID: https://orcid.org/0000-0002-1970-9349 (2015) Individuals with higher metabolic rates have lower levels of reactive oxygen species in vivo. Biology Letters, 11(9), 20150538. (doi: 10.1098/rsbl.2015.0538) (PMID:26382073)

Schanstra, J.P. et al. (2015) Diagnosis and prediction of CKD progression by assessment of urinary peptides. Journal of the American Society of Nephrology, 26(8), pp. 1999-2010. (doi: 10.1681/asn.2014050423) (PMID:25589610) (PMCID:PMC4520165)

Silva, S., Combet, E. ORCID: https://orcid.org/0000-0002-9302-8971, Figueira, M. E., Koeck, T., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563 and Bronze, M. R. (2015) New perspectives on bioactivity of olive oil: evidence from animal models, human interventions and the use of urinary proteomic biomarkers. Proceedings of the Nutrition Society, 74(03), pp. 268-281. (doi: 10.1017/S0029665115002323) (PMID:26186673)

Nally, Jarlath E., Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Callanan, John J., Mischak, Harald and Albalat, Amaya (2015) Detection of urinary biomarkers in reservoir hosts of leptospirosis by capillary electrophoresis-mass spectrometry. Proteomics Clinical Applications, 9(5-6), pp. 543-551. (doi: 10.1002/prca.201400205) (PMID:25736478)

Pejchinovski, Martin, Klein, Julie, Ramírez-Torres, Adela, Bitsika, Vasiliki, Mermelekas, George, Vlahou, Antonia, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Mischak, Harald and Jankowski, Vera (2015) Comparison of higher energy collisional dissociation and collision-induced dissociation MS/MS sequencing methods for identification of naturally occurring peptides in human urine. Proteomics Clinical Applications, 9(5-6), pp. 531-542. (doi: 10.1002/prca.201400163) (PMID:25821083)

Pontillo, Claudia, Filip, Szymon, Borràs, Daniel M., Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Vlahou, Antonia and Mischak, Harald (2015) CE-MS-based proteomics in biomarker discovery and clinical application. Proteomics Clinical Applications, 9(3-4), pp. 322-334. (doi: 10.1002/prca.201400115) (PMID:25641774)

Kuhla, Björn, Laeger, Thomas, Husi, Holger and Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563 (2015) Cerebrospinal fluid prohormone processing and neuropeptides stimulating feed intake of dairy cows during early lactation. Journal of Proteome Research, 14(2), pp. 823-828. (doi: 10.1021/pr500872k) (PMID:25547169)

Silva, Sandra, Bronze, Maria R., Figueira, Maria E., Siwy, Justina, Mischak, Harald, Combet, Emilie ORCID: https://orcid.org/0000-0002-9302-8971 and Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563 (2015) Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study. American Journal of Clinical Nutrition, 101(4), pp. 44-54. (doi: 10.3945/ajcn.114.094219) (PMID:25527749)

Brown, C. E. et al. (2015) Urinary proteomic biomarkers to predict cardiovascular events. Proteomics Clinical Applications, 9(5-6), pp. 610-617. (doi: 10.1002/prca.201400195) (PMID:25786980)

Filip, S., Vougas, K., Zoidakis, J., Latosinska, A., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Spasovski, G., Mischak, H., Vlahou, A. and Jankowski, J. (2015) Comparison of depletion strategies for the enrichment of low-abundance proteins in urine. PLoS ONE, 10(7), e0133773. (doi: 10.1371/journal.pone.0133773) (PMID:26208298) (PMCID:PMC4514849)

Stalmach, Angelique ORCID: https://orcid.org/0000-0003-4491-654X, Husi, Holger, Mosbahi, Khedidja, Albalat, Amaya, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563 and Mischak, Harald (2015) Methods in capillary electrophoresis coupled to mass spectrometry for the identification of clinical proteomic/peptidomic biomarkers in biofluids. Methods in Molecular Biology, 1243, pp. 187-205. (doi: 10.1007/978-1-4939-1872-0_11)

2014

Seetho, I. W. et al. (2014) Urinary proteomics in obstructive sleep apnoea and obesity. European Journal of Clinical Investigation, 44(11), pp. 1104-1115. (doi: 10.1111/eci.12346) (PMID:25267120)

Siwy, J. et al. (2014) Multicentre prospective validation of a urinary peptidome-based classifier for the diagnosis of type 2 diabetic nephropathy. Nephrology Dialysis Transplantation, 29(8), pp. 1563-1570. (doi: 10.1093/ndt/gfu039)

Husi, Holger, Van Agtmael, Tom ORCID: https://orcid.org/0000-0003-4282-449X, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Bahlmann, Ferdinand H., Schanstra, Joost P., Vlahou, Antonia, Delles, Christian ORCID: https://orcid.org/0000-0003-2238-2612, Perco, Paul and Mischak, Harald (2014) Proteome-based systems biology analysis of the diabetic mouse aorta reveals major changes in fatty acid biosynthesis as potential hallmark in diabetes mellitus-associated vascular disease. Circulation: Cardiovascular Genetics, 7(2), pp. 161-170. (doi: 10.1161/CIRCGENETICS.113.000196)

Klein, Julie, Papadopoulos, Theofilos, Mischak, Harald and Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563 (2014) Comparison of CE-MS/MS and LC-MS/MS sequencing demonstrates significant complementarity in natural peptide identification in human urine. Electrophoresis, 35(7), pp. 1060-1064. (doi: 10.1002/elps.201300327)

Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Saigusa, Daisuke, Abe, Takaaki, Adamski, Jerzy and Mischak, Harald (2014) Proteomics and metabolomics as tools to unravel novel culprits and mechanisms of uremic toxicity: instrument or hype? Seminars in Nephrology, 34(2), pp. 180-190. (doi: 10.1016/j.semnephrol.2014.02.009)

Frantzi, M. et al. (2014) Discovery and validation of urinary biomarkers for detection of renal cell carcinoma. Journal of Proteomics, 98C, pp. 44-58. (doi: 10.1016/j.jprot.2013.12.010)

Klein, Julie, Buffin-Meyer, Benedicte, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Carty, David M, Delles, Christian ORCID: https://orcid.org/0000-0003-2238-2612, Vlahou, Antonia, Mischak, Harald, Decramer, Stéphane, Bascands, Jean-Loup and Schanstra, Joost P (2014) Clinical proteomics in obstetrics and neonatology. Expert Review of Proteomics, 11(1), pp. 75-89. (doi: 10.1586/14789450.2014.872564)

Albalat, Amaya, Husi, Holger, Siwy, Justyna, Nally, Jarlath E., McLaughlin, Mark ORCID: https://orcid.org/0000-0001-5317-2090, Eckersall, Peter D. ORCID: https://orcid.org/0000-0001-5254-5502 and Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563 (2014) Capillary electrophoresis interfaced with a mass spectrometer (CE-MS): technical considerations and applicability for biomarker studies in animals. Current Protein and Peptide Science, 15(1), pp. 23-35. (doi: 10.2174/1389203715666140221123920) (PMID:24555889)

Koss, M. J. et al. (2014) Proteomics of vitreous humor of patients with exudative age-related macular degeneration. PLoS ONE, 9(5), e96895. (doi: 10.1371/journal.pone.0096895) (PMID:24828575) (PMCID:PMC4020801)

Latosinska, Agnieszka, Frantzi, Maria, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Vlahou, Antonia and Makridakis, Manousos (2014) Targeting the proteome of cellular fractions: focus on secreted proteins. Methods in Molecular Biology, 1243, pp. 29-41. (doi: 10.1007/978-1-4939-1872-0_2)

Nkuipou-Kenfack, E. et al. (2014) Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease. PLoS ONE, 9(5), e96955. (doi: 10.1371/journal.pone.0096955) (PMID:24817014) (PMCID:PMC4016198)

Stalmach, Angelique ORCID: https://orcid.org/0000-0003-4491-654X, Johnsson, Hanna, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280, Husi, Holger, Klein, Julie, Dakna, Mohammed, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Mischak, Harald and Porter, Duncan (2014) Identification of urinary peptide biomarkers associated with rheumatoid arthritis. PLoS ONE, 9(8), e104625. (doi: 10.1371/journal.pone.0104625) (PMID:25144639) (PMCID:PMC4140712)

Tedesco, Sara, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563 and Cristobal, Susana (2014) High-throughput proteomics: a new tool for quality and safety in fishery products. Current Protein and Peptide Science, 15(2), pp. 118-133. (doi: 10.2174/1389203715666140221120219)

Weissinger, Eva M., Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563 and Albalat, Amaya (2014) Urinary proteomics employing capillary electrophoresis coupled to mass spectrometry in the monitoring of patients after stem cell transplantation. Methods in Molecular Biology, 1109, pp. 293-306. (doi: 10.1007/978-1-4614-9437-9_15)

2013

Frantzi, M. et al. (2013) IMAC fractionation in combination with LC–MS reveals H2B and NIF-1 peptides as potential bladder cancer biomarkers. Journal of Proteome Research, 12(9), pp. 3969-3979. (doi: 10.1021/pr400255h)

Klein, J. et al. (2013) Fetal urinary peptides to predict postnatal outcome of renal disease in fetuses with posterior urethral valves(PUV). Science Translational Medicine, 5(198), 198ra106. (doi: 10.1126/scitranslmed.3005807)

Mansor, R., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Albalat, A., Zerefos, P., Mischak, H., Barrett, D.C., Biggs, A. and Eckersall, P.D. ORCID: https://orcid.org/0000-0001-5254-5502 (2013) A peptidomic approach to biomarker discovery for bovine mastitis. Journal of Proteomics, 85, pp. 89-98. (doi: 10.1016/j.jprot.2013.04.027)

Stalmach, A. ORCID: https://orcid.org/0000-0003-4491-654X, Albalat, A., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563 and Mischak, H. (2013) Recent advances in capillary electrophoresis coupled to mass spectrometry for clinical proteomic applications. Electrophoresis, 34(11), pp. 1452-1464. (doi: 10.1002/elps.201200708)

Dissard, R. et al. (2013) Long term metabolic syndrome induced by a high fat high fructose diet leads to minimal renal injury in C57BL/6 mice. PLoS ONE, 8(10), e76703. (doi: 10.1371/journal.pone.0076703) (PMID:24098551) (PMCID:PMC3789664)

Husi, H., Sanchez-Niño, M., Delles, C. ORCID: https://orcid.org/0000-0003-2238-2612, Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Vlahou, A., Ortiz, A. and Mischak, H. (2013) A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI. BMC Systems Biology, 7(110), (doi: 10.1186/1752-0509-7-110)

Kistler, A.D. et al. (2013) Urinary proteomic biomarkers for diagnosis and risk stratification of autosomal dominant polycystic kidney disease: a multicentric study. PLoS ONE, 8(1), e53016. (doi: 10.1371/journal.pone.0053016) (PMID:23326375) (PMCID:PMC3542378)

Metzger, J. et al. (2013) Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders. Gut, 62(1), pp. 122-130. (doi: 10.1136/gutjnl-2012-302047)

Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Nemzer, B., Stalmach, A. ORCID: https://orcid.org/0000-0003-4491-654X, Sidrah, A. and Combet, E. ORCID: https://orcid.org/0000-0002-9302-8971 (2013) The polyphenolic and hydroxycinnamate contents of whole coffee fruits from China, India and Mexico. Journal of Agricultural and Food Chemistry, 61(22), pp. 5298-5309. (doi: 10.1021/jf4003126)

Weissinger, E.M. et al. (2013) Proteomic peptide profiling for preemptive diagnosis of acute graft-versus-host-disease after allogeneic stem cell transplantation. Leukemia, (doi: 10.1038/leu.2013.210)

2012

Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563 (2012) The human urinary proteome: combinational approaches to comprehensive mapping. Expert Review of Proteomics, 9(4), pp. 375-377. (doi: 10.1586/epr.12.36)

Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Albalat, A., Gonzalez, J., Zerefos, P., Siwy, J., Franke, J. and Mischak, H. (2012) Performance of different separation methods interfaced in the same MS-reflection TOF detector: a comparison of performance between CE versus HPLC for biomarker analysis. Electrophoresis, 33(4), pp. 567-574. (doi: 10.1002/elps.201100415)

Dawson, J. ORCID: https://orcid.org/0000-0001-7532-2475, Walters, M. ORCID: https://orcid.org/0000-0001-5743-5871, Delles, C. ORCID: https://orcid.org/0000-0003-2238-2612, Mischak, H. and Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563 (2012) Urinary proteomics to support diagnosis of stroke. PLoS ONE, 7(5), e35879. (doi: 10.1371/journal.pone.0035879) (PMID:22615742) (PMCID:PMC3353991)

Kitson, S.M. ORCID: https://orcid.org/0009-0002-5112-1059, Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Cogdell, R.J. ORCID: https://orcid.org/0000-0003-2119-6607, Bill, R.M. and Fraser, N.J. (2012) GPCR production in a novel yeast strain that makes cholesterol-like sterols. Methods, 55(4), pp. 287-292. (doi: 10.1016/j.ymeth.2011.09.023) (PMID:22001123)

Kuznetsova, T., Mischak, H., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563 and Staessen, J.A. (2012) Urinary proteome analysis in hypertensive patients with left ventricular diastolic dysfunction. European Heart Journal, 33(18), pp. 2342-2350. (doi: 10.1093/eurheartj/ehs185)

Omar, M.H., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Stalmach, A. ORCID: https://orcid.org/0000-0003-4491-654X, Auger, C., Rouanet, J.-M., Teissedre, P.-L., Caldwell, S.T. ORCID: https://orcid.org/0000-0003-1604-3462, Hartley, R.C. ORCID: https://orcid.org/0000-0003-1033-5405 and Crozier, A. (2012) Absorption, disposition, metabolism, and excretion of [3-¹⁴C]caffeic acid in rats. Journal of Agricultural and Food Chemistry, 60(20), pp. 5205-5214. (doi: 10.1021/jf3001185)

Rouse, R., Siwy, J., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Mischak, H., Metzger, J. and Hanig, J. (2012) Proteomic candidate biomarkers of drug-induced nephrotoxicity in the rat. PLoS ONE, 7(4), e34606. (doi: 10.1371/journal.pone.0034606) (PMID:22509332) (PMCID:PMC3324487)

Siwy, J. et al. (2012) Evaluation of the zucker diabetic fatty (ZDF) rat as a model for human disease based on urinary peptidomic profiles. PLoS ONE, 7(12), e51334. (doi: 10.1371/journal.pone.0051334) (PMID:23236474) (PMCID:PMC3517416)

2011

Albalat, A., Mischak, H. and Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563 (2011) Urine proteomics in clinical applications: technologies, principal considerations and clinical implementation. Prilozi, 32(1), pp. 13-44.

AlGamdi, N., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563 and Crozier, A. (2011) Tea prepared from Anastatica hirerochuntica seeds contains a diversity of antioxidant flavonoids, chlorogenic acids and phenolic compounds. Phytochemistry, 72(2-3), pp. 248-254. (doi: 10.1016/j.phytochem.2010.11.017)

Lopez, L.M., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Zürbig, P., Harris, S.E., Gow, A.J., Starr, J.M., Porteous, D.J., Mischak, H. and Deary, I.J. (2011) A pilot study of urinary peptides as biomarkers for intelligence in old age. Intelligence, 39(1), pp. 46-53. (doi: 10.1016/j.intell.2010.11.001)

Albalat, A., Gornik, S.G., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Crozier, A., Atkinson, R.J.A, Coombs, G.H. and Neil, D.M. ORCID: https://orcid.org/0000-0001-9390-5631 (2011) Quality changes in chilled Norway lobster (Nephrops norvegicus) tail meat and the effects of delayed icing. International Journal of Food Science and Technology, 46(7), pp. 1413-1421. (doi: 10.1111/j.1365-2621.2011.02650.x)

Albalat, A., Mischak, H. and Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563 (2011) Clinical application of urinary proteomics/peptidomics. Expert Review of Proteomics, 8(5), pp. 615-629. (doi: 10.1586/epr.11.46)

Carty, D.M. et al. (2011) Urinary proteomics for prediction of preeclampsia. Hypertension, 57(3), pp. 561-569. (doi: 10.1161/HYPERTENSIONAHA.110.164285)

Kistler, A.D. et al. (2011) A distinct urinary biomarker pattern characteristic of female fabry patients that mirrors response to enzyme replacement therapy. PLoS ONE, 6(6), e20534. (doi: 10.1371/journal.pone.0020534) (PMID:21698285) (PMCID:PMC3115947)

Metzger, J. et al. (2011) Diagnosis of subclinical and clinical acute T-cell-mediated rejection in renal transplant patients by urinary proteome analysis. Proteomics Clinical Applications, 5(5-6), pp. 322-333. (doi: 10.1002/prca.201000153)

Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Delles, C. ORCID: https://orcid.org/0000-0003-2238-2612 and Mischak, H. (2011) Urinary proteomics in the assessment of chronic kidney disease. Current Opinion in Nephrology and Hypertension, 20(6), pp. 654-661. (doi: 10.1097/MNH.0b013e32834b7ffa)

Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Gonzalez, J., Siwy, J., Franke, J., Sattar, N. ORCID: https://orcid.org/0000-0002-1604-2593, Mullan, A., Roberts, S., Delles, C. ORCID: https://orcid.org/0000-0003-2238-2612, Mischak, H. and Albalat, A. (2011) A pilot study on the effect of short-term consumption of a polyphenol rich drink on biomarkers of coronary artery disease defined by urinary proteomics. Journal of Agricultural and Food Chemistry, 59(24), pp. 12850-12857. (doi: 10.1021/jf203369r) (PMID:22070129)

Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Nemzer, B., Ou, B., Stalmach, A. ORCID: https://orcid.org/0000-0003-4491-654X, Hunter, J., Clifford, M.N. and Combet, E. ORCID: https://orcid.org/0000-0002-9302-8971 (2011) The antioxidant and chlorogenic acid profiles of whole coffee fruits are influenced by the extraction procedures. Journal of Agricultural and Food Chemistry, 59(8), pp. 3754-3762. (doi: 10.1021/jf200122m)

Omar, M.H., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563 and Crozier, A. (2011) Identification of proanthocyanidin dimers and trimers, FlavoneC-Glycosides, and antioxidants in Ficus deltoidea, a Malaysian herbal tea. Journal of Agricultural and Food Chemistry, 59(4), pp. 1363-1369. (doi: 10.1021/jf1032729)

Siwy, J., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Golovko, I., Franke, J. and Zürbig, P. (2011) Human urinary peptide database for multiple disease biomarker discovery. Proteomics Clinical Applications, 5(5-6), pp. 367-374. (doi: 10.1002/prca.201000155)

Wittke, S., Jahn, H., Z, P., Kellmann, M., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Eichenlaub, M. and Mischak, H. (2011) Peptide fingerprinting of Alzheimer's disease in cerebrospinal fluid: identification and prospective evaluation of new synaptic biomarkers. PLoS ONE, 6(10), e26540. (doi: 10.1371/journal.pone.0026540) (PMID:22046305) (PMCID:PMC3202544)

2010

Borges, G., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563 and Crozier, A. (2010) Comparison of the polyphenolic composition and antioxidant activity of European commercial fruit juices. Food and Function, 1(1), pp. 73-83. (doi: 10.1039/c0fo00008f)

Borges, G., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Mullan, A., Lean, M. ORCID: https://orcid.org/0000-0003-2216-0083, Roberts, S. and Crozier, A. (2010) Bioavailability of multiple components following acute ingestion of a polyphenol-rich juice drink. Molecular Nutrition and Food Research, 54(S2), S268-S277. (doi: 10.1002/mnfr.200900611)

Borges, G., Degeneve, A., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563 and Crozier, A. (2010) Identification of flavonoid and phenolic antioxidants in black currants, blueberries, raspberries, red currants, and cranberries. Journal of Agricultural and Food Chemistry, 58(7), pp. 3901-3909. (doi: 10.1021/jf902263n)

Ashihara, H., Deng, W.-W., Mullen, W. and Crozier, A. (2010) Distribution and biosynthesis of flavan-3-ols in Camellia sinensis seedlings and expression of genes encoding biosynthetic enzymes. Phytochemistry, 71(5-6), pp. 559-566. (doi: 10.1016/j.phytochem.2010.01.010)

Stalmach, A. ORCID: https://orcid.org/0000-0003-4491-654X, Mullen, W., Steiling, H., Williamson, G., Lean, M.E.J. and Crozier, A. (2010) Absorption, metabolism, and excretion of green tea flavan-3-ols in humans with an ileostomy. Molecular Nutrition and Food Research, 54(3), pp. 323-334. (doi: 10.1002/mnfr.200900194)

Gonzalez-Barrio, R., Borges, G., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563 and Crozier, A. (2010) Bioavailability of Anthocyanins and Ellagitannins Following Consumption of Raspberries by Healthy Humans and Subjects with an Ileostomy. Journal of Agricultural and Food Chemistry, 58(7), pp. 3933-3939. (doi: 10.1021/jf100315d)

González-Barrio, R., Borges, G., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563 and Crozier, A. (2010) Bioavailability of Anthocyanins and Ellagitannins Following Consumption of Raspberries by Healthy Humans and Subjects with an Ileostomy†. Journal of Agricultural and Food Chemistry, 58(7), pp. 3933-3939. (doi: 10.1021/jf100315d)

Larcombe, Stephen D., Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Alexander, Lucille and Arnold, Kathryn E. (2010) Dietary antioxidants, lipid peroxidation and plumage colouration in nestling blue tits Cyanistes caeruleus. Naturwissenschaften, 97(10), pp. 903-913. (doi: 10.1007/s00114-010-0708-5)

Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Larcombe, Stephen, Arnold, Kathryn, Welchman, Helen and Crozier, Alan (2010) Use of accurate mass full scan mass spectrometry for the analysis of anthocyanins in berries and berry-fed tissues. Journal of Agricultural and Food Chemistry, 58(7), pp. 3910-3915. (doi: 10.1021/jf902267v)

Mullen, W., Borges, G., Lean, M.E.J., Roberts, S.A. and Crozier, A. (2010) Identification of metabolites in human plasma and urine after consumption of a polyphenol-rich juice drink. Journal of Agricultural and Food Chemistry, 58(4), pp. 2586-2595. (doi: 10.1021/jf904096v)

Roowi, S., Stalmach, A., Mullen, W., Lean, M., Edwards, C.A. and Crozier, A. (2010) Green tea flavan-3-ols: colonic degradation and urinary excretion of catabolites by humans. Journal of Agricultural and Food Chemistry, 58(2), pp. 1296-1304. (doi: 10.1021/jf9032975)

Troufflard, Stephanie, Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Larson, Tony R, Graham, Ian A, Crozier, A., Amtmann, A. ORCID: https://orcid.org/0000-0001-8533-121X and Armengaud, P. (2010) Potassium deficiency induces the biosynthesis of oxylipins and glucosinolates in Arabidopsis thaliana. BMC Plant Biology, 10(1), p. 172. (doi: 10.1186/1471-2229-10-172)

Wright, B., Moraes, L.A., Kemp, C.F., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Crozier, A., Lovegrove, J.A. and Gibbins, J.M. (2010) A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids. British Journal of Pharmacology, 159(6), pp. 1312-1325. (doi: 10.1111/j.1476-5381.2009.00632.x)

2009

Jaganath, I.B., Mullen, W., Lean, M., Edwards, C.A. and Crozier, A. (2009) In vitro catabolism of rutin by human fecal bacteria and the antioxidant capacity of its catabolites. Free Radical Biology and Medicine, 47(8), pp. 1180-1189. (doi: 10.1016/j.freeradbiomed.2009.07.031)

Stalmach, A. ORCID: https://orcid.org/0000-0003-4491-654X, Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Barron, D., Uchida, K., Yokota, T., Cavin, C., Steiling, H., Williamson, G. and Crozier, A. (2009) Metabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans: identification of biomarkers of coffee consumption. Drug Metabolism and Disposition, 37(8), pp. 1749-1758. (doi: 10.1124/dmd.109.028019)

Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Borges, G,, Donovan, J.L., Edwards, C.A. ORCID: https://orcid.org/0000-0003-0406-918X, Serafini, M., Lean, M.E.J. ORCID: https://orcid.org/0000-0003-2216-0083 and Crozier, A. (2009) Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans. American Journal of Clinical Nutrition, 89(6), pp. 1784-1791. (doi: 10.3945/ajcn.2008.27339) (PMID:19403635)

Marks, S.C., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Borges, G. and Crozier, A. (2009) Absorption, Metabolism, and Excretion of Cider Dihydrochalcones in Healthy Humans and Subjects with an Ileostomy. Journal of Agricultural and Food Chemistry, 57(5), pp. 2009-2015. (doi: 10.1021/jf802757x)

Renouf, M. et al. (2009) Metabolism of chlorogenic acids after coffee ingestion in ileostomy and healthy subjects. In: 22nd International Conference on Coffee Science, ASIC 2008, Campinas, Brazil, 14-19 September 2008, pp. 110-117.

Roowi, S., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Edwards, C.A. ORCID: https://orcid.org/0000-0003-0406-918X and Crozier, A. (2009) Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans. Molecular Nutrition and Food Research, 53(Suppl), S68-S75. (doi: 10.1002/mnfr.200800287)

Stalmach, A. ORCID: https://orcid.org/0000-0003-4491-654X, Mullen, W., Pecorari, M., Serafini, M. and Crozier, A. (2009) Bioavailability of c-linked dihydrochalcone and flavanone glucosides in humans following ingestion of unfermented and fermented rooibos teas. Journal of Agricultural and Food Chemistry, 57(15), pp. 7104-7111. (doi: 10.1021/jf9011642)

2008

Jordão, A.M., Ricardo-Da-Silva, J.M., Laureano, O., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563 and Crozier, A. (2008) Effect of ellagitannins, ellagic acid and volatile compounds from oak wood on the (+)-catechin, procyanidin B1 and malvidin-3-glucoside content of model wines. Australian Journal of Grape and Wine Research, 14(3), pp. 260-270.

Auger, Cyril, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Hara, Yukihiko and Crozier, Alan (2008) Bioavailability of polyphenon E flavan-3-ols in humans with an lleostomy. Journal of Nutrition, 138(8), 1535S-1542S.

Gauliard, B, Grieve, D, Wilson, R, Crozier, A, Jenkins, CJ, Mullen, WD ORCID: https://orcid.org/0000-0002-5685-1563 and Lean, M (2008) The effects of dietary phenolic compounds on cytokine and antioxidant production by a549 cells. Journal of Medicinal Food, 11(2), pp. 382-384. (doi: 10.1089/jmf.2007.593)

Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Archeveque, Marie-Amelie, Edwards, C.A. ORCID: https://orcid.org/0000-0003-0406-918X, Matsumoto, Hikaru and Crozier, A. (2008) Bioavailability and Metabolism of Orange Juice Flavanones in Humans: Impact of a Full-Fat Yogurt. Journal of Agricultural and Food Chemistry, 56(23), pp. 11157-11164. (doi: 10.1021/jf801974v)

Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Edwards, C.A., Serafini, M. and Crozier, A. (2008) Bioavailability of pelargonidin-3-O-glucoside and its metabolites in humans following the ingestion of strawberries with and without cream. Journal of Agricultural and Food Chemistry, 56(3), pp. 713-719. (doi: 10.1021/jf072000p)

Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Rouanet, J.-M., Auger, C., Teissèdre, P.-L., Caldwell, S.T. ORCID: https://orcid.org/0000-0003-1604-3462, Hartley, R.C. ORCID: https://orcid.org/0000-0003-1033-5405, Lean, M.E.J. ORCID: https://orcid.org/0000-0003-2216-0083, Edwards, C.A. ORCID: https://orcid.org/0000-0003-0406-918X and Crozier, A. (2008) Bioavailability of [2-14C]Quercetin-4′-glucoside in rats. Journal of Agricultural and Food Chemistry, 56(24), pp. 12127-12137. (doi: 10.1021/jf802754s)

2007

Combet, E. ORCID: https://orcid.org/0000-0002-9302-8971, Paterson, S., Iijima, K., Winter, J., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Crozier, A., Preston, T. ORCID: https://orcid.org/0000-0002-9900-5682 and McColl, K.E.L. (2007) Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation. Gut, 56, pp. 1678-1684. (doi: 10.1136/gut.2007.128587)

Marks, S.C., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563 and Crozier, A. (2007) Flavonoid and hydroxycinnamate profiles of English apple ciders. Journal of Agricultural and Food Chemistry, 55, pp. 8723-8730. (doi: 10.1021/jf071155u)

2006

Stalmach, A. ORCID: https://orcid.org/0000-0003-4491-654X, Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Nagai, A. and Crozier, A. (2006) On-line HPLC analysis of the antioxidant activity of phenolic compounds in brewed, paper-filtered coffee. Brazilian Journal of Plant Physiology, 18(1), pp. 253-262. (doi: 10.1590/S1677-04202006000100018)

This list was generated on Sun Jun 15 07:27:34 2025 BST.

Jump to: Articles | Book Sections | Conference Proceedings

Number of items: 136.

Articles

He, T. et al. (2021) Urinary peptides in heart failure: a link to molecular pathophysiology. European Journal of Heart Failure, 23(11), pp. 1875-1887. (doi: 10.1002/ejhf.2195) (PMID:33881206)

Schanstra, J. P. et al. (2019) Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment. JCI Insight, 4(10), e125638. (doi: 10.1172/jci.insight.125638)

Ortiz, A. et al. (2017) Mitogen-activated protein kinase 14 promotes AKI. Journal of the American Society of Nephrology, 28(3), pp. 823-836. (doi: 10.1681/ASN.2015080898) (PMID:27620989)

Reich, M. et al. (2016) Proteomic analysis of vitreous humor in retinal vein occlusion. PLoS ONE, 11(6), e0158001. (doi: 10.1371/journal.pone.0158001) (PMID:27362861) (PMCID:PMC4928959)

Brown, C. E. et al. (2015) Urinary proteomic biomarkers to predict cardiovascular events. Proteomics Clinical Applications, 9(5-6), pp. 610-617. (doi: 10.1002/prca.201400195) (PMID:25786980)

Seetho, I. W. et al. (2014) Urinary proteomics in obstructive sleep apnoea and obesity. European Journal of Clinical Investigation, 44(11), pp. 1104-1115. (doi: 10.1111/eci.12346) (PMID:25267120)

Frantzi, M. et al. (2014) Discovery and validation of urinary biomarkers for detection of renal cell carcinoma. Journal of Proteomics, 98C, pp. 44-58. (doi: 10.1016/j.jprot.2013.12.010)

Carty, D.M. et al. (2011) Urinary proteomics for prediction of preeclampsia. Hypertension, 57(3), pp. 561-569. (doi: 10.1161/HYPERTENSIONAHA.110.164285)

Book Sections

Conference Proceedings

This list was generated on Sun Jun 15 07:27:34 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

The African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT)
Medical Research Council
2016 - 2020
Manipulating the activity of the gut microbiota with fermentable carbohydrates to maximise the bioavailability of bioactive phenolic acids for health
Biotechnology and Biological Sciences Research Council
2015 - 2018
Urinary proteomic profile as a biomarker for preclinical Dementia and cognitive ageing
Academy of Medical Sciences
2015 - 2016
Metabolite and protein profiling in CADASIL to unravel the vascular pathophysiology and natural history
NHS Greater Glasgow and Clyde Endowment Funds
2014 - 2016
SysVasc
European Commission
2014 - 2018
IMODE-CKD: Clinical and system-omics for the identification of the Molecular Determinants of established Chronic Kidney Disease
European Commission
2013 - 2017
Urine proteomics as biomarker for inflammatory arthritis
Pfizer
2013 - 2014
Can a football-based weight management, physical activity and healthy living programme be adapted for delivery in secure institutional settings to support at risk groups in positive, sustainable ....
Chief Scientist Office
2013 - 2016
Global Prostate Cancer Biomarker Initiative.
Movember Group PTY Limited
2012 - 2015
Investigating the potential of cathepsin-L as a common therapeutic target and biomarker for coronary heart disease and African trypanosomiasis (ISSF Catalyst Fund)
Wellcome Trust
2011 - 2014
The iomarkers in Stroke Programme; Detecting, Understanding, and Predicting Outcome After Stroke (ISSF Catalyst Fund)
Wellcome Trust
2011 - 2014

Dr Bill Mullen

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Dr Bill Mullen

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