Bunyamwera virus (BUNV) is the prototype of the family Bunyaviridae, and causes a mild febrile illness in humans. It is named after the area in western Uganda where it was first isolated. BUNV remains an important research model: it was the first bunyavirus whose genome was completely sequenced, and significantly was the first segmented genome negative sense RNA virus that was recovered (rescued) entirely from cloned cDNA.
Research in CVR uses BUNV to investigate aspects of bunyavirus glycoprotein processing and as a screening tool to determine interferon-stimulated genes that have anti-viral activity against bunyaviruses.
Fluorescently labelled Bunyamwera viral proteins in cells, viewed by confocal microscopy