Dr Ruth Mackenzie

  • Research Associate (Institute of Cardiovascular & Medical Sciences)

telephone: 0141 330 8428
email: Ruth.Mackenzie@glasgow.ac.uk

RC433 Level C4, Institute of C&MS, BHF GCRC, Glasgow G12 8TA, G12 8TA

Biography

I graduated from the University of Glasgow in 2002 with a first class M.Sci. (Hons) in Genetics. After a brief spell in the financial sector and a less brief spell travelling, I returned to the University in 2005 and completed my British Heart Foundation (BHF) funded PhD, ‘Oxidative Stress in Endothelial Cells of Patients with Coronary Artery Disease’, in 2009 under the supervision of Dr William Miller and Professor Dame Anna Dominiczak. On completion of my PhD, I received additional BHF funding to continue my work on the role of AMP-activated protein kinase and oxidative stress in endothelial dysfunction. This work was carried out with Professor Dominiczak and Professor Christian Delles with whom I also studied gene expression profiles in the endothelium of women with pre-eclampsia.

In 2011 I joined Professor Andrew Baker’s group to study the directed endothelial differentiation of human embryonic stem cells. During my time in Professor Baker’s group, I was also involved in investigating the role of microRNAs and long noncoding RNAs in vascular smooth muscle cell biology and pathology.

I returned to Professor Delles’ group in 2014 where I worked on the EU-funded SysVASC project. Here, we utilised a systems medicine approach to better understand the development of cardiovascular disease and identify biomarkers for earlier diagnosis and therapeutic intervention.

After 12 years in the lab, I finally hung up my pipette in 2017 to work with Dr Jennifer Logue on the development of a core outcome set for UK lifestyle weight management programmes.

I’m currently investigating long-term outcomes following bariatric surgery as part of the Surgical Obesity Treatment Study (SCOTS).

Publications

List by: Type | Date

Jump to: 2021 | 2020 | 2019 | 2018 | 2016 | 2013 | 2012 | 2008
Number of items: 12.

2021

Mackenzie, R. M. et al. (2021) SurgiCal Obesity Treatment Study (SCOTS): a prospective, observational cohort study on health and socioeconomic burden in treatment-seeking individuals with severe obesity in Scotland, UK. BMJ Open, 11(8), e046441. (doi: 10.1136/bmjopen-2020-046441) (PMID:34446484)

2020

Heggie, L., MacKenzie, R. M., Ells, L. J., Simpson, S. A. and Logue, J. (2020) Tackling reporting issues and variation in behavioural weight management interventions: Design and piloting of the standardized reporting of adult behavioural weight management interventions to aid evaluation (STAR‐LITE) template. Clinical Obesity, 10(5), e12390. (doi: 10.1111/cob.12390) (PMID:32632970)

Mackenzie, R. M., Ells, L. J., Simpson, S. A. and Logue, J. (2020) Core outcome set for behavioural weight management interventions for adults with overweight and obesity: standardised reporting of lifestyle weight management interventions to aid evaluation (STAR-LITE). Obesity Reviews, 21(2), e12961. (doi: 10.1111/obr.12961) (PMID:31756274) (PMCID:PMC7050499)

2019

Mackenzie, R. M., Ells, L. J., Simpson, S. A. and Logue, J. (2019) Development of a core outcome set for behavioural weight management programmes for adults with overweight and obesity: protocol for obtaining expert consensus using Delphi methodology. BMJ Open, 9(2), e025193. (doi: 10.1136/bmjopen-2018-025193) (PMID:30826797) (PMCID:PMC6398651)

2018

Grieve, E. , MacKenzie, R. M., Munro, J., O'Donnell, J., Stewart, S., Ali, A., Bruce, D., Trevor, M. and Logue, J. (2018) Variations in bariatric surgical care pathways: a national costing study on the variability of services and impact on costs. BMC Obesity, 5, 43. (doi: 10.1186/s40608-018-0223-3) (PMID:30607251) (PMCID:PMC6307243)

2016

Ballantyne, M. D. et al. (2016) Smooth muscle enriched long noncoding RNA (SMILR) regulates cell proliferation. Circulation, 133(21), pp. 2050-2065. (doi: 10.1161/circulationaha.115.021019) (PMID:27052414) (PMCID:PMC4872641)

2013

Rossi, S. H. et al. (2013) Impaired renal function impacts negatively on vascular stiffness in patients with coronary artery disease. BMC Nephrology, 14(173), (doi: 10.1186/1471-2369-14-173)

MacKenzie, R.M. et al. (2013) Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes. Clinical Science, 124(6), pp. 403-411. (doi: 10.1042/CS20120239)

Howard, L., MacKenzie, R. M., Pchelintsev, N. A., McBryan, T., McClure, J. D. , McBride, M. W. , Kane, N. M., Adams, P. D., Milligan, G. and Baker, A. H. (2013) Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment. Stem Cell Research and Therapy, 4(2), Art. 36. (doi: 10.1186/scrt192)

2012

MacKenzie, R.M., Sandrim, V.C., Carty, D.M., McClure, J.D. , Freeman, D.J. , Dominiczak, A.F. , McBride, M.W. and Delles, C. (2012) Endothelial FOS expression and pre-eclampsia. BJOG: An International Journal of Obstetrics and Gynaecology, 119(13), pp. 1564-1571. (doi: 10.1111/1471-0528.12016)

Kane, N. M. et al. (2012) Role of MicroRNAs 99b, 181a, and 181b in the differentiation of human embryonic stem cells to vascular endothelial cells. Stem Cells, 30(4), pp. 643-654. (doi: 10.1002/stem.1026)

2008

Miller, W., Graham, D., Douglas, K., MacKenzie, R. and Dominiczak, A. (2008) Metabolic phenotypes in SHRSP and chromosome 2 congenic strains. Journal of Human Hypertension, 22(10), pp. 736-737.

This list was generated on Mon Dec 6 05:03:45 2021 GMT.
Jump to: Articles
Number of items: 12.

Articles

Mackenzie, R. M. et al. (2021) SurgiCal Obesity Treatment Study (SCOTS): a prospective, observational cohort study on health and socioeconomic burden in treatment-seeking individuals with severe obesity in Scotland, UK. BMJ Open, 11(8), e046441. (doi: 10.1136/bmjopen-2020-046441) (PMID:34446484)

Heggie, L., MacKenzie, R. M., Ells, L. J., Simpson, S. A. and Logue, J. (2020) Tackling reporting issues and variation in behavioural weight management interventions: Design and piloting of the standardized reporting of adult behavioural weight management interventions to aid evaluation (STAR‐LITE) template. Clinical Obesity, 10(5), e12390. (doi: 10.1111/cob.12390) (PMID:32632970)

Mackenzie, R. M., Ells, L. J., Simpson, S. A. and Logue, J. (2020) Core outcome set for behavioural weight management interventions for adults with overweight and obesity: standardised reporting of lifestyle weight management interventions to aid evaluation (STAR-LITE). Obesity Reviews, 21(2), e12961. (doi: 10.1111/obr.12961) (PMID:31756274) (PMCID:PMC7050499)

Mackenzie, R. M., Ells, L. J., Simpson, S. A. and Logue, J. (2019) Development of a core outcome set for behavioural weight management programmes for adults with overweight and obesity: protocol for obtaining expert consensus using Delphi methodology. BMJ Open, 9(2), e025193. (doi: 10.1136/bmjopen-2018-025193) (PMID:30826797) (PMCID:PMC6398651)

Grieve, E. , MacKenzie, R. M., Munro, J., O'Donnell, J., Stewart, S., Ali, A., Bruce, D., Trevor, M. and Logue, J. (2018) Variations in bariatric surgical care pathways: a national costing study on the variability of services and impact on costs. BMC Obesity, 5, 43. (doi: 10.1186/s40608-018-0223-3) (PMID:30607251) (PMCID:PMC6307243)

Ballantyne, M. D. et al. (2016) Smooth muscle enriched long noncoding RNA (SMILR) regulates cell proliferation. Circulation, 133(21), pp. 2050-2065. (doi: 10.1161/circulationaha.115.021019) (PMID:27052414) (PMCID:PMC4872641)

Rossi, S. H. et al. (2013) Impaired renal function impacts negatively on vascular stiffness in patients with coronary artery disease. BMC Nephrology, 14(173), (doi: 10.1186/1471-2369-14-173)

MacKenzie, R.M. et al. (2013) Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes. Clinical Science, 124(6), pp. 403-411. (doi: 10.1042/CS20120239)

Howard, L., MacKenzie, R. M., Pchelintsev, N. A., McBryan, T., McClure, J. D. , McBride, M. W. , Kane, N. M., Adams, P. D., Milligan, G. and Baker, A. H. (2013) Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment. Stem Cell Research and Therapy, 4(2), Art. 36. (doi: 10.1186/scrt192)

MacKenzie, R.M., Sandrim, V.C., Carty, D.M., McClure, J.D. , Freeman, D.J. , Dominiczak, A.F. , McBride, M.W. and Delles, C. (2012) Endothelial FOS expression and pre-eclampsia. BJOG: An International Journal of Obstetrics and Gynaecology, 119(13), pp. 1564-1571. (doi: 10.1111/1471-0528.12016)

Kane, N. M. et al. (2012) Role of MicroRNAs 99b, 181a, and 181b in the differentiation of human embryonic stem cells to vascular endothelial cells. Stem Cells, 30(4), pp. 643-654. (doi: 10.1002/stem.1026)

Miller, W., Graham, D., Douglas, K., MacKenzie, R. and Dominiczak, A. (2008) Metabolic phenotypes in SHRSP and chromosome 2 congenic strains. Journal of Human Hypertension, 22(10), pp. 736-737.

This list was generated on Mon Dec 6 05:03:45 2021 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • BEhavioural weight management: COMponents for Effectiveness
    National Institute for Health Research
    2020 - 2023