Dr Alyson Miller

  • Senior Lecturer (Institute of Cardiovascular & Medical Sciences)

Biography

Dr Alyson Miller graduated from the University of Strathclyde with a BSc (First Class Honours) in Immunology and Pharmacology, and a PhD in Cardiovascular Pharmacology from the University of Edinburgh. After a short post-doctoral position at University College London, she moved to Australia to continue her post-doctoral training, initially at the University of Melbourne and then at Monash University. In 2007, she was awarded a Foundation for High Blood Pressure Research Fellowship followed by a National Health and Medical Research Council (NHMRC) of Australia Career Development Fellowship (2009-2013). In 2013, she was awarded a Vice-Chancellor’s Senior Research Fellowship from RMIT University, where she established her independent research program. Alyson returned to Scotland in early 2017 to take up a Senior Lecturer position in the Institute of Cardiovascular and Medical Sciences (BHF Glasgow Cardiovascular Research Centre) at the University of Glasgow. Alyson’s research has consistently been funded by competitive research grants, largely from the NHMRC, and she has received a number of prestigious international and Australian young scientist awards in recognition of her research contributions. 

Research interests

Over the past 12 years, Dr Miller’s research has used a multidisciplinary and collaborative approach to study the complex mechanisms that regulate cerebral artery function and brain blood flow during health; and identify abnormalities underlying the cerebral artery dysfunction and inadequate brain blood flow that accompanies cardiovascular disease and stroke. This research has made significant contributions to our understanding of fundamental reactive oxygen species (ROS) signalling in cerebral arteries; the multi-complex enzymes that generate ROS (the Nox oxidases), and how these enzymes contribute to cerebral artery dysfunction in the setting of cardiovascular risk factors and after stroke. The primary focus of Dr Miller’s current research is the identification of therapeutic targets and ‘multi-target’ candidate drugs for the prevention and treatment of stroke. The scope of this research extends beyond the traditional research approach of identifying novel therapeutics for brain injury. Indeed, it also seeks to identify strategies to modify post-stroke systemic complications including immunosuppression, weight loss/muscle wasting, and lung injury, which are also key determinants of stroke outcome. 

Publications

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Number of items: 60.

2020

McFall, A. et al. (2020) UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings. Journal of Cerebral Blood Flow and Metabolism, 40(7), pp. 1402-1414. (doi: 10.1177/0271678X20910552) (PMID:32151228) (PMCID:PMC7307003)

De Luca, S. N., Miller, A. A. , Sominsky, L. and Spencer, S. J. (2020) Microglial regulation of satiety and cognition. Journal of Neuroendocrinology, 32(3), e12838. (doi: 10.1111/jne.12838) (PMID:32097992)

2019

Bernard, A., Ku, J. M., Vlahos, R. and Miller, A. A. (2019) Cigarette smoke extract exacerbates hyperpermeability of cerebral endothelial cells after oxygen glucose deprivation and reoxygenation. Scientific Reports, 9(1), 15573. (doi: 10.1038/s41598-019-51728-2) (PMID:31666540) (PMCID:PMC6821697)

Austin, V., Miller, A. and Vlahos, R. (2019) Prior cigarette smoke exposure does not affect acute post-stroke outcomes in mice. PLoS ONE, 14(3), e0214246. (doi: 10.1371/journal.pone.0214246) (PMID:30897180)

Austin, V., Ku, J. M., Miller, A. A. and Vlahos, R. (2019) Ischaemic stroke in mice induces lung inflammation but not acute lung injury. Scientific Reports, 9(1), 3622. (doi: 10.1038/s41598-019-40392-1) (PMID:30842652) (PMCID:PMC6403328)

2018

Horsburgh, K. et al. (2018) Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clinical Science, 132(8), pp. 851-868. (doi: 10.1042/CS20171620) (PMID:29712883)

Chan, S. M.H., Lowe, M. P., Bernard, A., Miller, A. A. and Herbert, T. P. (2018) The inositol-requiring enzyme 1 (IRE1α) RNAse inhibitor, 4µ8C, is also a potent cellular antioxidant. Biochemical Journal, 475(5), pp. 923-929. (doi: 10.1042/BCJ20170678) (PMID:29463644)

2017

Chan, S. M.H., Lau, Y.-S., Miller, A. A. , Ku, J. M., Potocnik, S., Ye, J.-M., Woodman, O. L. and Herbert, T. P. (2017) Angiotensin II causes β-cell dysfunction through an ER stress-induced proinflammatory response. Endocrinology, 158(10), pp. 3162-3173. (doi: 10.1210/en.2016-1879) (PMID:28938442)

Ng, H. H., Yildiz, G. S., Ku, J. M., Miller, A. A. , Woodman, O. L. and Hart, J. L. (2017) Chronic NaHS treatment decreases oxidative stress and improves endothelial function in diabetic mice. Diabetes and Vascular Disease Research, 14(3), pp. 246-253. (doi: 10.1177/1479164117692766) (PMID:28467198)

2016

Austin, V., Crack, P. J., Bozinovski, S., Miller, A. A. and Vlahos, R. (2016) COPD and stroke: are systemic inflammation and oxidative stress the missing links? Clinical Science, 130(13), pp. 1039-1050. (doi: 10.1042/CS20160043) (PMID:27215677) (PMCID:PMC4876483)

Ku, J. M., Taher, M., Chin, K. Y., Grace, M., McIntyre, P. and Miller, A. A. (2016) Characterisation of a mouse cerebral microvascular endothelial cell line (bEnd.3) after oxygen glucose deprivation and reoxygenation. Clinical and Experimental Pharmacology and Physiology, 43(8), pp. 777-786. (doi: 10.1111/1440-1681.12587) (PMID:27128638)

Ku, J. M., Taher, M., Chin, K. Y., Barsby, T., Austin, V., Wong, C. H.Y., Andrews, Z. B., Spencer, S. J. and Miller, A. A. (2016) Protective actions of des-acylated ghrelin on brain injury and blood-brain barrier disruption after stroke in mice. Clinical Science, 130(17), pp. 1545-1558. (doi: 10.1042/CS20160077) (PMID:27303049)

De Luca, S. N., Ziko, I., Sominsky, L., Nguyen, J. C.D., Dinan, T., Miller, A. A. , Jenkins, T. A. and Spencer, S. J. (2016) Early life overfeeding impairs spatial memory performance by reducing microglial sensitivity to learning. Journal of Neuroinflammation, 13(1), 112. (doi: 10.1186/s12974-016-0578-7) (PMID:27193330) (PMCID:PMC4872342)

Ku, J. M., Sleeman, M. W., Sobey, C. G., Andrews, Z. B. and Miller, A. A. (2016) Ghrelin-related peptides do not modulate vasodilator nitric oxide production or superoxide levels in mouse systemic arteries. Clinical and Experimental Pharmacology and Physiology, 43(4), pp. 468-475. (doi: 10.1111/1440-1681.12548) (PMID:26800483)

De Silva, T. M. and Miller, A. A. (2016) Cerebral small vessel disease: targeting oxidative stress as a novel therapeutic strategy? Frontiers in Pharmacology, 7, 61. (doi: 10.3389/fphar.2016.00061) (PMID:27014073) (PMCID:PMC4794483)

Jackman, K. A., Cumming, T. and Miller, A. A. (2016) Stroke, cognitive function, and Alzheimer’s disease. In: Lazarov, O. and Tesco, G. (eds.) Genes, Environment and Alzheimer's Disease. Elsevier, pp. 319-359. ISBN 9780128028513 (doi:10.1016/B978-0-12-802851-3.00011-5)

2015

Chau, B. A., Drummond, G., Jackson, W. R., Jarrott, B., Miller, A. A. , Subasinghe, K. R., Tan, C. Y.R., White, P. J., Wright, C. E. and Ziogas, J. (2015) Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents. MedChemComm, 6(4), pp. 634-639. (doi: 10.1039/C4MD00459K)

Ku, J. M., Andrews, Z. B., Barsby, T., Reichenbach, A., Lemus, M. B., Drummond, G. R., Sleeman, M. W., Spencer, S. J., Sobey, C. G. and Miller, A. A. (2015) Ghrelin-related peptides exert protective effects in the cerebral circulation of male mice through a nonclassical ghrelin receptor(s). Endocrinology, 156(1), pp. 280-290. (doi: 10.1210/en.2014-1415) (PMID:25322462) (PMCID:PMC4272401)

2014

Miller, A. A. and Spencer, S. J. (2014) Obesity and neuroinflammation: a pathway to cognitive impairment. Brain, Behavior, and Immunity, 42, pp. 10-21. (doi: 10.1016/j.bbi.2014.04.001) (PMID:24727365)

Rickard, A. J., Morgan, J., Chrissobolis, S., Miller, A. A. , Sobey, C. G. and Young, M. J. (2014) Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure. Hypertension, 63(5), pp. 1033-1040. (doi: 10.1161/HYPERTENSIONAHA.113.01803) (PMID:24566081)

McCarthy, C. A., Vinh, A., Miller, A. A. , Hallberg, A., Alterman, M., Callaway, J. K. and Widdop, R. E. (2014) Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats. PLoS ONE, 9(4), e95762. (doi: 10.1371/journal.pone.0095762) (PMID:24752645) (PMCID:PMC3994132)

Broughton, B. R.S. et al. (2014) Sex-dependent effects of G protein-coupled estrogen receptor activity on outcome after ischemic stroke. Stroke, 45(3), pp. 835-841. (doi: 10.1161/STROKEAHA.113.001499) (PMID:24457292)

Al-Magableh, M. R., Kemp-Harper, B. K., Ng, H. H., Miller, A. A. and Hart, J. L. (2014) Hydrogen sulfide protects endothelial nitric oxide function under conditions of acute oxidative stress in vitro. Naunyn-Schmiedeberg's Archives of Pharmacology, 387(1), pp. 67-74. (doi: 10.1007/s00210-013-0920-x) (PMID:24068103)

Miller, A. A. , De Silva, T. M., Drummond, G. R., Sobey, C. G. and Chrissobolis, S. (2014) Reactive oxygen species and cerebrovascular diseases. In: Laher, I. (ed.) Systems Biology of Free Radicals and Antioxidants. Springer Verlag: Heidelberg, pp. 1895-1924. ISBN 9783642300172 (doi:10.1007/978-3-642-30018-9_78)

2013

Miller, A. A. et al. (2013) Nitroxyl (HNO) suppresses vascular Nox2 oxidase activity. Free Radical Biology and Medicine, 60, pp. 264-271. (doi: 10.1016/j.freeradbiomed.2013.02.025) (PMID:23459072)

Kenny, R., Cai, G., Bayliss, J. A., Clarke, M., Choo, Y. L., Miller, A. A. , Andrews, Z. B. and Spencer, S. J. (2013) Endogenous ghrelin's role in hippocampal neuroprotection after global cerebral ischemia: does endogenous ghrelin protect against global stroke? American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 304(11), R980-R990. (doi: 10.1152/ajpregu.00594.2012) (PMID:23576609) (PMCID:23576609)

Spencer, S., Miller, A. and Andrews, Z. (2013) The role of Ghrelin in neuroprotection after ischemic brain injury. Brain Sciences, 3(1), pp. 344-359. (doi: 10.3390/brainsci3010344) (PMID:24961317) (PMCID:PMC4061836)

Broughton, B. R.S., Brait, V. H., Guida, E., Lee, S., Arumugam, T. V., Gardiner-Mann, C. V., Miller, A. A. , Tang, S.-C., Drummond, G. R. and Sobey, C. G. (2013) Stroke increases G protein-coupled estrogen receptor expression in the brain of male but not female mice. Neurosignals, 21(3-4), pp. 229-239. (doi: 10.1159/000338019) (PMID:22869326)

Duce, J.A. et al. (2013) Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels. Molecular Psychiatry, 18(2), pp. 245-254. (doi: 10.1038/mp.2011.168) (PMID:22212595)

2012

Kim, H. A., Miller, A. A. , Drummond, G. R., Thrift, A. G., Arumugam, T. V., Phan, T. G., Srikanth, V. K. and Sobey, C. G. (2012) Vascular cognitive impairment and Alzheimer’s disease: role of cerebral hypoperfusion and oxidative stress. Naunyn-Schmiedeberg's Archives of Pharmacology, 385(10), pp. 953-959. (doi: 10.1007/s00210-012-0790-7) (PMID:22872171)

2011

De Silva, T. M., Brait, V. H., Drummond, G. R., Sobey, C. G. and Miller, A. A. (2011) Nox2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke. PLoS ONE, 6(12), e28393. (doi: 10.1371/journal.pone.0028393) (PMID:22164282) (PMCID:PMC3229592)

Bullen, M.L., Miller, A.A. , Dharmarajah, J., Drummond, G.R., Sobey, C. G. and Kemp-Harper, B.K. (2011) Vasorelaxant and antiaggregatory actions of the nitroxyl donor isopropylamine NONOate are maintained in hypercholesterolemia. AJP: Heart and Circulatory Physiology, 301(4), H1405-H1414. (doi: 10.1152/ajpheart.00489.2011) (PMID:21803947)

Bullen, M. L., Miller, A. A. , Andrews, K. L., Irvine, J. C., Ritchie, R. H., Sobey, C. G. and Kemp-Harper, B. K. (2011) Nitroxyl (HNO) as a vasoprotective signaling molecule. Antioxidants and Redox Signaling, 14(9), pp. 1675-1686. (doi: 10.1089/ars.2010.3327) (PMID:2067312)

Chrissobolis, S., Miller, A.A. , Drummond, G.R., Sobey, C.G. and Kemp-Harper, B.K. (2011) Oxidative stress and endothelial dysfunction in cerebrovascular disease. Frontiers in Bioscience, 16(1), p. 1733. (doi: 10.2741/3816) (PMID:21196259)

Miller, A. A. and Sobey, C. G. (2011) Vascular biology and atherosclerosis of cerebral arteries. In: Mohr, J.P., Choi, D., Grotta, J.C., Weir, B. and Wolg, P.A. (eds.) Stroke: Pathophysiology, Diagnosis and Management [5th ed.]. Elsevier/Saunders: Philadelphia, PA, pp. 3-15. ISBN 9781416054788 (doi:10.1016/B978-1-4160-5478-8.10001-6)

2010

Gray, G. A., Patrizio, M., Sherry, L., Miller, A. A. , Malaki, M., Wallace, A. F., Leiper, J. M. and Vallance, P. (2010) Immunolocalisation and activity of DDAH I and II in the heart and modification post-myocardial infarctioN. Acta Histochemica, 112(5), pp. 413-423. (doi: 10.1016/j.acthis.2009.02.009) (PMID:19481782)

Miller, A. A. , Budzyn, K. and Sobey, C. G. (2010) Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention. Clinical Science, 119(1), pp. 1-17. (doi: 10.1042/CS20090649) (PMID:20370718)

Broughton, B. R.S., Miller, A. A. and Sobey, C. G. (2010) Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries. AJP: Heart and Circulatory Physiology, 298(3), H1055-H1061. (doi: 10.1152/ajpheart.00878.2009) (PMID:20061543)

Judkins, C. P., Diep, H., Broughton, B. R.S., Mast, A. E., Hooker, E. U., Miller, A. A. , Selemidis, S., Dusting, G. J., Sobey, C. G. and Drummond, G. R. (2010) Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice. AJP: Heart and Circulatory Physiology, 298(1), H24-H32. (doi: 10.1152/ajpheart.00799.2009) (PMID:19837950)

Miller, A. A. , De Silva, T. M., Judkins, C. P., Diep, H., Drummond, G. R. and Sobey, C. G. (2010) Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia. Stroke, 41(4), pp. 784-789. (doi: 10.1161/STROKEAHA.109.575365) (PMID:20167907)

2009

Jackman, K. A., Miller, A. , Drummond, G. R. and Sobey, C. G. (2009) Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke. Brain Research, 1286, pp. 215-220. (doi: 10.1016/j.brainres.2009.06.056) (PMID:19559686)

Kemp-Harper, B., Ravi, R., Bullen, M., Ritchie, R., Sobey, C. and Miller, A. (2009) Nitroxyl, the novel redox sibling of NO, suppresses cerebrovascular NADPH oxidase. BMC Pharmacology, 9(Suppl), P31. (doi: 10.1186/1471-2210-9-S1-P31) (PMCID:PMC3313343)

De Silva, T. M., Broughton, B. R.S., Drummond, G. R., Sobey, C. G. and Miller, A. A. (2009) Gender influences cerebral vascular responses to Angiotensin II through Nox2-derived reactive oxygen species. Stroke, 40(4), pp. 1091-1097. (doi: 10.1161/STROKEAHA.108.531707) (PMID:19211495)

Jackman, K.A., Miller, A.A. , De Silva, T.M., Crack, P.J., Drummond, G.R. and Sobey, C.G. (2009) Reduction of cerebral infarct volume by apocynin requires pretreatment and is absent in Nox2-deficient mice. British Journal of Pharmacology, 156(4), pp. 680-688. (doi: 10.1111/j.1476-5381.2008.00073.x) (PMID:19175604) (PMCID:PMC2697707)

Budzyn, K., Ravi, R.M., Miller, A.A. and Sobey, C.G. (2009) Mechanisms of augmented vasoconstriction induced by 5-hydroxytryptamine in aortic rings from spontaneously hypertensive rats. British Journal of Pharmacology, 155(2), pp. 210-216. (doi: 10.1038/bjp.2008.247) (PMID:18552867) (PMCID:PMC2538692)

Miller, A. A. , Drummond, G. R., De Silva, T. M., Mast, A. E., Hickey, H., Williams, J. P., Broughton, B. R.S. and Sobey, C. G. (2009) NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: role of Nox2. AJP: Heart and Circulatory Physiology, 296(1), H220-H225. (doi: 10.1152/ajpheart.00987.2008) (PMID:19028794)

2007

Miller, A. A. , De Silva, T. M., Jackman, K. A. and Sobey, C. G. (2007) Effect of gender and sex hormones on vascular oxidative stress. Clinical and Experimental Pharmacology and Physiology, 34(10), pp. 1037-1043. (doi: 10.1111/j.1440-1681.2007.04732.x) (PMID:17714091)

Miller, A. A. , Drummond, G. R., Mast, A. E., Schmidt, H. H.H.W. and Sobey, C. G. (2007) Effect of gender on NADPH-oxidase activity, expression, and function in the cerebral circulation: role of estrogen. Stroke, 38(7), pp. 2142-2149. (doi: 10.1161/STROKEAHA.106.477406) (PMID:17525399)

2006

Miller, A. A. , Dusting, G. J., Roulston, C. L. and Sobey, C. G. (2006) NADPH-oxidase activity is elevated in penumbral and non-ischemic cerebral arteries following stroke. Brain Research, 1111(1), pp. 111-116. (doi: 10.1016/j.brainres.2006.06.082) (PMID:16879806)

Miller, A. , Drummond, G. R. and Sobey, C. G. (2006) Reactive oxygen species in the cerebral circulation: are they all bad? Antioxidants and Redox Signaling, 8(7-8), pp. 1113-1120. (doi: 10.1089/ars.2006.8.1113) (PMID:16910759)

Miller, A. A. , Drummond, G. R. and Sobey, C. G. (2006) Novel isoforms of NADPH-oxidase in cerebral vascular control. Pharmacology and Therapeutics, 111(3), pp. 928-948. (doi: 10.1016/j.pharmthera.2006.02.005) (PMID:16616784)

Paravicini, T. M., Miller, A. A. , Drummond, G. R. and Sobey, C. G. (2006) Flow-induced cerebral vasodilatation in vivo involves activation of phosphatidylinositol-3 kinase, NADPH-oxidase, and nitric oxide synthase. Journal of Cerebral Blood Flow and Metabolism, 26(6), pp. 836-845. (doi: 10.1038/sj.jcbfm.9600235) (PMID:16222243)

Sobey, C.G. and Miller, A.A. (2006) Radicals spark interest in cerebral vasodilator mechanisms. Focus on "TNF- dilates cerebral arteries via NAD(P)H oxidase-dependent Ca2+ spark activation". AJP: Cell Physiology, 290(4), C950-C951. (doi: 10.1152/ajpcell.00601.2005) (PMID:16531572)

Judkins, C. P., Sobey, C. G., Dang, T. T., Miller, A. A. , Dusting, G. J. and Drummond, G. R. (2006) NADPH-induced contractions of mouse aorta do not involve NADPH Oxidase: A role for P2X receptors. Journal of Pharmacology and Experimental Therapeutics, 317(2), pp. 644-650. (doi: 10.1124/jpet.105.096610) (PMID:16407465)

2005

Miller, A. A. , Drummond, G. R., Schmidt, H. H.H.W. and Sobey, C. G. (2005) NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries. Circulation Research, 97(10), pp. 1055-1062. (doi: 10.1161/01.RES.0000189301.10217.87) (PMID:16210546)

Miller, A. A. , Drummond, G. R. and Sobey, C. G. (2005) Selective inhibition of NADPH-oxidase isoforms as a therapeutic strategy in hypertension. Drug Discovery Today: Therapeutic Strategies, 2(3), pp. 187-192. (doi: 10.1016/j.ddstr.2005.08.002)

Miller, A. A. , Hislop, A. A., Vallance, P. J. and Haworth, S. G. (2005) Deletion of the eNOS gene has a greater impact on the pulmonary circulation of male than female mice. American Journal of Physiology: Lung Cellular and Molecular Physiology, 289(2), L299-L366. (doi: 10.1152/ajplung.00022.2005) (PMID:15821017)

Nandi, M., Miller, A. , Stidwill, R., Jacques, T. S., Lam, A. A.J., Haworth, S., Heales, S. and Vallance, P. (2005) Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse. Circulation, 111(16), pp. 2086-2090. (doi: 10.1161/01.CIR.0000163268.32638.F4) (PMID:15824199)

Sobey, C. G. and Miller, A. A. (2005) Signalling pathways activated by hydrogen peroxide in vascular smooth muscle. Journal of Hypertension, 23(11), pp. 1961-1962. (doi: 10.1097/01.hjh.0000184409.96672.ab) (PMID:16208134)

2000

Miller, A. A. , Megson, I. L. and Gray, G. A. (2000) Inducible nitric oxide synthase-derived superoxide contributes to hypereactivity in small mesenteric arteries from a rat model of chronic heart failure. British Journal of Pharmacology, 131(1), pp. 29-36. (doi: 10.1038/sj.bjp.0703528) (PMID:10960065) (PMCID:PMC1572288)

This list was generated on Sat Aug 15 08:58:25 2020 BST.
Number of items: 60.

Articles

McFall, A. et al. (2020) UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings. Journal of Cerebral Blood Flow and Metabolism, 40(7), pp. 1402-1414. (doi: 10.1177/0271678X20910552) (PMID:32151228) (PMCID:PMC7307003)

De Luca, S. N., Miller, A. A. , Sominsky, L. and Spencer, S. J. (2020) Microglial regulation of satiety and cognition. Journal of Neuroendocrinology, 32(3), e12838. (doi: 10.1111/jne.12838) (PMID:32097992)

Bernard, A., Ku, J. M., Vlahos, R. and Miller, A. A. (2019) Cigarette smoke extract exacerbates hyperpermeability of cerebral endothelial cells after oxygen glucose deprivation and reoxygenation. Scientific Reports, 9(1), 15573. (doi: 10.1038/s41598-019-51728-2) (PMID:31666540) (PMCID:PMC6821697)

Austin, V., Miller, A. and Vlahos, R. (2019) Prior cigarette smoke exposure does not affect acute post-stroke outcomes in mice. PLoS ONE, 14(3), e0214246. (doi: 10.1371/journal.pone.0214246) (PMID:30897180)

Austin, V., Ku, J. M., Miller, A. A. and Vlahos, R. (2019) Ischaemic stroke in mice induces lung inflammation but not acute lung injury. Scientific Reports, 9(1), 3622. (doi: 10.1038/s41598-019-40392-1) (PMID:30842652) (PMCID:PMC6403328)

Horsburgh, K. et al. (2018) Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clinical Science, 132(8), pp. 851-868. (doi: 10.1042/CS20171620) (PMID:29712883)

Chan, S. M.H., Lowe, M. P., Bernard, A., Miller, A. A. and Herbert, T. P. (2018) The inositol-requiring enzyme 1 (IRE1α) RNAse inhibitor, 4µ8C, is also a potent cellular antioxidant. Biochemical Journal, 475(5), pp. 923-929. (doi: 10.1042/BCJ20170678) (PMID:29463644)

Chan, S. M.H., Lau, Y.-S., Miller, A. A. , Ku, J. M., Potocnik, S., Ye, J.-M., Woodman, O. L. and Herbert, T. P. (2017) Angiotensin II causes β-cell dysfunction through an ER stress-induced proinflammatory response. Endocrinology, 158(10), pp. 3162-3173. (doi: 10.1210/en.2016-1879) (PMID:28938442)

Ng, H. H., Yildiz, G. S., Ku, J. M., Miller, A. A. , Woodman, O. L. and Hart, J. L. (2017) Chronic NaHS treatment decreases oxidative stress and improves endothelial function in diabetic mice. Diabetes and Vascular Disease Research, 14(3), pp. 246-253. (doi: 10.1177/1479164117692766) (PMID:28467198)

Austin, V., Crack, P. J., Bozinovski, S., Miller, A. A. and Vlahos, R. (2016) COPD and stroke: are systemic inflammation and oxidative stress the missing links? Clinical Science, 130(13), pp. 1039-1050. (doi: 10.1042/CS20160043) (PMID:27215677) (PMCID:PMC4876483)

Ku, J. M., Taher, M., Chin, K. Y., Grace, M., McIntyre, P. and Miller, A. A. (2016) Characterisation of a mouse cerebral microvascular endothelial cell line (bEnd.3) after oxygen glucose deprivation and reoxygenation. Clinical and Experimental Pharmacology and Physiology, 43(8), pp. 777-786. (doi: 10.1111/1440-1681.12587) (PMID:27128638)

Ku, J. M., Taher, M., Chin, K. Y., Barsby, T., Austin, V., Wong, C. H.Y., Andrews, Z. B., Spencer, S. J. and Miller, A. A. (2016) Protective actions of des-acylated ghrelin on brain injury and blood-brain barrier disruption after stroke in mice. Clinical Science, 130(17), pp. 1545-1558. (doi: 10.1042/CS20160077) (PMID:27303049)

De Luca, S. N., Ziko, I., Sominsky, L., Nguyen, J. C.D., Dinan, T., Miller, A. A. , Jenkins, T. A. and Spencer, S. J. (2016) Early life overfeeding impairs spatial memory performance by reducing microglial sensitivity to learning. Journal of Neuroinflammation, 13(1), 112. (doi: 10.1186/s12974-016-0578-7) (PMID:27193330) (PMCID:PMC4872342)

Ku, J. M., Sleeman, M. W., Sobey, C. G., Andrews, Z. B. and Miller, A. A. (2016) Ghrelin-related peptides do not modulate vasodilator nitric oxide production or superoxide levels in mouse systemic arteries. Clinical and Experimental Pharmacology and Physiology, 43(4), pp. 468-475. (doi: 10.1111/1440-1681.12548) (PMID:26800483)

De Silva, T. M. and Miller, A. A. (2016) Cerebral small vessel disease: targeting oxidative stress as a novel therapeutic strategy? Frontiers in Pharmacology, 7, 61. (doi: 10.3389/fphar.2016.00061) (PMID:27014073) (PMCID:PMC4794483)

Chau, B. A., Drummond, G., Jackson, W. R., Jarrott, B., Miller, A. A. , Subasinghe, K. R., Tan, C. Y.R., White, P. J., Wright, C. E. and Ziogas, J. (2015) Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents. MedChemComm, 6(4), pp. 634-639. (doi: 10.1039/C4MD00459K)

Ku, J. M., Andrews, Z. B., Barsby, T., Reichenbach, A., Lemus, M. B., Drummond, G. R., Sleeman, M. W., Spencer, S. J., Sobey, C. G. and Miller, A. A. (2015) Ghrelin-related peptides exert protective effects in the cerebral circulation of male mice through a nonclassical ghrelin receptor(s). Endocrinology, 156(1), pp. 280-290. (doi: 10.1210/en.2014-1415) (PMID:25322462) (PMCID:PMC4272401)

Miller, A. A. and Spencer, S. J. (2014) Obesity and neuroinflammation: a pathway to cognitive impairment. Brain, Behavior, and Immunity, 42, pp. 10-21. (doi: 10.1016/j.bbi.2014.04.001) (PMID:24727365)

Rickard, A. J., Morgan, J., Chrissobolis, S., Miller, A. A. , Sobey, C. G. and Young, M. J. (2014) Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure. Hypertension, 63(5), pp. 1033-1040. (doi: 10.1161/HYPERTENSIONAHA.113.01803) (PMID:24566081)

McCarthy, C. A., Vinh, A., Miller, A. A. , Hallberg, A., Alterman, M., Callaway, J. K. and Widdop, R. E. (2014) Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats. PLoS ONE, 9(4), e95762. (doi: 10.1371/journal.pone.0095762) (PMID:24752645) (PMCID:PMC3994132)

Broughton, B. R.S. et al. (2014) Sex-dependent effects of G protein-coupled estrogen receptor activity on outcome after ischemic stroke. Stroke, 45(3), pp. 835-841. (doi: 10.1161/STROKEAHA.113.001499) (PMID:24457292)

Al-Magableh, M. R., Kemp-Harper, B. K., Ng, H. H., Miller, A. A. and Hart, J. L. (2014) Hydrogen sulfide protects endothelial nitric oxide function under conditions of acute oxidative stress in vitro. Naunyn-Schmiedeberg's Archives of Pharmacology, 387(1), pp. 67-74. (doi: 10.1007/s00210-013-0920-x) (PMID:24068103)

Miller, A. A. et al. (2013) Nitroxyl (HNO) suppresses vascular Nox2 oxidase activity. Free Radical Biology and Medicine, 60, pp. 264-271. (doi: 10.1016/j.freeradbiomed.2013.02.025) (PMID:23459072)

Kenny, R., Cai, G., Bayliss, J. A., Clarke, M., Choo, Y. L., Miller, A. A. , Andrews, Z. B. and Spencer, S. J. (2013) Endogenous ghrelin's role in hippocampal neuroprotection after global cerebral ischemia: does endogenous ghrelin protect against global stroke? American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 304(11), R980-R990. (doi: 10.1152/ajpregu.00594.2012) (PMID:23576609) (PMCID:23576609)

Spencer, S., Miller, A. and Andrews, Z. (2013) The role of Ghrelin in neuroprotection after ischemic brain injury. Brain Sciences, 3(1), pp. 344-359. (doi: 10.3390/brainsci3010344) (PMID:24961317) (PMCID:PMC4061836)

Broughton, B. R.S., Brait, V. H., Guida, E., Lee, S., Arumugam, T. V., Gardiner-Mann, C. V., Miller, A. A. , Tang, S.-C., Drummond, G. R. and Sobey, C. G. (2013) Stroke increases G protein-coupled estrogen receptor expression in the brain of male but not female mice. Neurosignals, 21(3-4), pp. 229-239. (doi: 10.1159/000338019) (PMID:22869326)

Duce, J.A. et al. (2013) Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels. Molecular Psychiatry, 18(2), pp. 245-254. (doi: 10.1038/mp.2011.168) (PMID:22212595)

Kim, H. A., Miller, A. A. , Drummond, G. R., Thrift, A. G., Arumugam, T. V., Phan, T. G., Srikanth, V. K. and Sobey, C. G. (2012) Vascular cognitive impairment and Alzheimer’s disease: role of cerebral hypoperfusion and oxidative stress. Naunyn-Schmiedeberg's Archives of Pharmacology, 385(10), pp. 953-959. (doi: 10.1007/s00210-012-0790-7) (PMID:22872171)

De Silva, T. M., Brait, V. H., Drummond, G. R., Sobey, C. G. and Miller, A. A. (2011) Nox2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke. PLoS ONE, 6(12), e28393. (doi: 10.1371/journal.pone.0028393) (PMID:22164282) (PMCID:PMC3229592)

Bullen, M.L., Miller, A.A. , Dharmarajah, J., Drummond, G.R., Sobey, C. G. and Kemp-Harper, B.K. (2011) Vasorelaxant and antiaggregatory actions of the nitroxyl donor isopropylamine NONOate are maintained in hypercholesterolemia. AJP: Heart and Circulatory Physiology, 301(4), H1405-H1414. (doi: 10.1152/ajpheart.00489.2011) (PMID:21803947)

Bullen, M. L., Miller, A. A. , Andrews, K. L., Irvine, J. C., Ritchie, R. H., Sobey, C. G. and Kemp-Harper, B. K. (2011) Nitroxyl (HNO) as a vasoprotective signaling molecule. Antioxidants and Redox Signaling, 14(9), pp. 1675-1686. (doi: 10.1089/ars.2010.3327) (PMID:2067312)

Chrissobolis, S., Miller, A.A. , Drummond, G.R., Sobey, C.G. and Kemp-Harper, B.K. (2011) Oxidative stress and endothelial dysfunction in cerebrovascular disease. Frontiers in Bioscience, 16(1), p. 1733. (doi: 10.2741/3816) (PMID:21196259)

Gray, G. A., Patrizio, M., Sherry, L., Miller, A. A. , Malaki, M., Wallace, A. F., Leiper, J. M. and Vallance, P. (2010) Immunolocalisation and activity of DDAH I and II in the heart and modification post-myocardial infarctioN. Acta Histochemica, 112(5), pp. 413-423. (doi: 10.1016/j.acthis.2009.02.009) (PMID:19481782)

Miller, A. A. , Budzyn, K. and Sobey, C. G. (2010) Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention. Clinical Science, 119(1), pp. 1-17. (doi: 10.1042/CS20090649) (PMID:20370718)

Broughton, B. R.S., Miller, A. A. and Sobey, C. G. (2010) Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries. AJP: Heart and Circulatory Physiology, 298(3), H1055-H1061. (doi: 10.1152/ajpheart.00878.2009) (PMID:20061543)

Judkins, C. P., Diep, H., Broughton, B. R.S., Mast, A. E., Hooker, E. U., Miller, A. A. , Selemidis, S., Dusting, G. J., Sobey, C. G. and Drummond, G. R. (2010) Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice. AJP: Heart and Circulatory Physiology, 298(1), H24-H32. (doi: 10.1152/ajpheart.00799.2009) (PMID:19837950)

Miller, A. A. , De Silva, T. M., Judkins, C. P., Diep, H., Drummond, G. R. and Sobey, C. G. (2010) Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia. Stroke, 41(4), pp. 784-789. (doi: 10.1161/STROKEAHA.109.575365) (PMID:20167907)

Jackman, K. A., Miller, A. , Drummond, G. R. and Sobey, C. G. (2009) Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke. Brain Research, 1286, pp. 215-220. (doi: 10.1016/j.brainres.2009.06.056) (PMID:19559686)

Kemp-Harper, B., Ravi, R., Bullen, M., Ritchie, R., Sobey, C. and Miller, A. (2009) Nitroxyl, the novel redox sibling of NO, suppresses cerebrovascular NADPH oxidase. BMC Pharmacology, 9(Suppl), P31. (doi: 10.1186/1471-2210-9-S1-P31) (PMCID:PMC3313343)

De Silva, T. M., Broughton, B. R.S., Drummond, G. R., Sobey, C. G. and Miller, A. A. (2009) Gender influences cerebral vascular responses to Angiotensin II through Nox2-derived reactive oxygen species. Stroke, 40(4), pp. 1091-1097. (doi: 10.1161/STROKEAHA.108.531707) (PMID:19211495)

Jackman, K.A., Miller, A.A. , De Silva, T.M., Crack, P.J., Drummond, G.R. and Sobey, C.G. (2009) Reduction of cerebral infarct volume by apocynin requires pretreatment and is absent in Nox2-deficient mice. British Journal of Pharmacology, 156(4), pp. 680-688. (doi: 10.1111/j.1476-5381.2008.00073.x) (PMID:19175604) (PMCID:PMC2697707)

Budzyn, K., Ravi, R.M., Miller, A.A. and Sobey, C.G. (2009) Mechanisms of augmented vasoconstriction induced by 5-hydroxytryptamine in aortic rings from spontaneously hypertensive rats. British Journal of Pharmacology, 155(2), pp. 210-216. (doi: 10.1038/bjp.2008.247) (PMID:18552867) (PMCID:PMC2538692)

Miller, A. A. , Drummond, G. R., De Silva, T. M., Mast, A. E., Hickey, H., Williams, J. P., Broughton, B. R.S. and Sobey, C. G. (2009) NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: role of Nox2. AJP: Heart and Circulatory Physiology, 296(1), H220-H225. (doi: 10.1152/ajpheart.00987.2008) (PMID:19028794)

Miller, A. A. , De Silva, T. M., Jackman, K. A. and Sobey, C. G. (2007) Effect of gender and sex hormones on vascular oxidative stress. Clinical and Experimental Pharmacology and Physiology, 34(10), pp. 1037-1043. (doi: 10.1111/j.1440-1681.2007.04732.x) (PMID:17714091)

Miller, A. A. , Drummond, G. R., Mast, A. E., Schmidt, H. H.H.W. and Sobey, C. G. (2007) Effect of gender on NADPH-oxidase activity, expression, and function in the cerebral circulation: role of estrogen. Stroke, 38(7), pp. 2142-2149. (doi: 10.1161/STROKEAHA.106.477406) (PMID:17525399)

Miller, A. A. , Dusting, G. J., Roulston, C. L. and Sobey, C. G. (2006) NADPH-oxidase activity is elevated in penumbral and non-ischemic cerebral arteries following stroke. Brain Research, 1111(1), pp. 111-116. (doi: 10.1016/j.brainres.2006.06.082) (PMID:16879806)

Miller, A. , Drummond, G. R. and Sobey, C. G. (2006) Reactive oxygen species in the cerebral circulation: are they all bad? Antioxidants and Redox Signaling, 8(7-8), pp. 1113-1120. (doi: 10.1089/ars.2006.8.1113) (PMID:16910759)

Miller, A. A. , Drummond, G. R. and Sobey, C. G. (2006) Novel isoforms of NADPH-oxidase in cerebral vascular control. Pharmacology and Therapeutics, 111(3), pp. 928-948. (doi: 10.1016/j.pharmthera.2006.02.005) (PMID:16616784)

Paravicini, T. M., Miller, A. A. , Drummond, G. R. and Sobey, C. G. (2006) Flow-induced cerebral vasodilatation in vivo involves activation of phosphatidylinositol-3 kinase, NADPH-oxidase, and nitric oxide synthase. Journal of Cerebral Blood Flow and Metabolism, 26(6), pp. 836-845. (doi: 10.1038/sj.jcbfm.9600235) (PMID:16222243)

Sobey, C.G. and Miller, A.A. (2006) Radicals spark interest in cerebral vasodilator mechanisms. Focus on "TNF- dilates cerebral arteries via NAD(P)H oxidase-dependent Ca2+ spark activation". AJP: Cell Physiology, 290(4), C950-C951. (doi: 10.1152/ajpcell.00601.2005) (PMID:16531572)

Judkins, C. P., Sobey, C. G., Dang, T. T., Miller, A. A. , Dusting, G. J. and Drummond, G. R. (2006) NADPH-induced contractions of mouse aorta do not involve NADPH Oxidase: A role for P2X receptors. Journal of Pharmacology and Experimental Therapeutics, 317(2), pp. 644-650. (doi: 10.1124/jpet.105.096610) (PMID:16407465)

Miller, A. A. , Drummond, G. R., Schmidt, H. H.H.W. and Sobey, C. G. (2005) NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries. Circulation Research, 97(10), pp. 1055-1062. (doi: 10.1161/01.RES.0000189301.10217.87) (PMID:16210546)

Miller, A. A. , Drummond, G. R. and Sobey, C. G. (2005) Selective inhibition of NADPH-oxidase isoforms as a therapeutic strategy in hypertension. Drug Discovery Today: Therapeutic Strategies, 2(3), pp. 187-192. (doi: 10.1016/j.ddstr.2005.08.002)

Miller, A. A. , Hislop, A. A., Vallance, P. J. and Haworth, S. G. (2005) Deletion of the eNOS gene has a greater impact on the pulmonary circulation of male than female mice. American Journal of Physiology: Lung Cellular and Molecular Physiology, 289(2), L299-L366. (doi: 10.1152/ajplung.00022.2005) (PMID:15821017)

Nandi, M., Miller, A. , Stidwill, R., Jacques, T. S., Lam, A. A.J., Haworth, S., Heales, S. and Vallance, P. (2005) Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse. Circulation, 111(16), pp. 2086-2090. (doi: 10.1161/01.CIR.0000163268.32638.F4) (PMID:15824199)

Sobey, C. G. and Miller, A. A. (2005) Signalling pathways activated by hydrogen peroxide in vascular smooth muscle. Journal of Hypertension, 23(11), pp. 1961-1962. (doi: 10.1097/01.hjh.0000184409.96672.ab) (PMID:16208134)

Miller, A. A. , Megson, I. L. and Gray, G. A. (2000) Inducible nitric oxide synthase-derived superoxide contributes to hypereactivity in small mesenteric arteries from a rat model of chronic heart failure. British Journal of Pharmacology, 131(1), pp. 29-36. (doi: 10.1038/sj.bjp.0703528) (PMID:10960065) (PMCID:PMC1572288)

Book Sections

Jackman, K. A., Cumming, T. and Miller, A. A. (2016) Stroke, cognitive function, and Alzheimer’s disease. In: Lazarov, O. and Tesco, G. (eds.) Genes, Environment and Alzheimer's Disease. Elsevier, pp. 319-359. ISBN 9780128028513 (doi:10.1016/B978-0-12-802851-3.00011-5)

Miller, A. A. , De Silva, T. M., Drummond, G. R., Sobey, C. G. and Chrissobolis, S. (2014) Reactive oxygen species and cerebrovascular diseases. In: Laher, I. (ed.) Systems Biology of Free Radicals and Antioxidants. Springer Verlag: Heidelberg, pp. 1895-1924. ISBN 9783642300172 (doi:10.1007/978-3-642-30018-9_78)

Miller, A. A. and Sobey, C. G. (2011) Vascular biology and atherosclerosis of cerebral arteries. In: Mohr, J.P., Choi, D., Grotta, J.C., Weir, B. and Wolg, P.A. (eds.) Stroke: Pathophysiology, Diagnosis and Management [5th ed.]. Elsevier/Saunders: Philadelphia, PA, pp. 3-15. ISBN 9781416054788 (doi:10.1016/B978-1-4160-5478-8.10001-6)

This list was generated on Sat Aug 15 08:58:25 2020 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Defining the role of the ADMA-DDAH1 pathway in ischaemic stroke
    British Heart Foundation
    2020 - 2023
     
  • Examining the impact of the gut-microbiota-derived metabolite on neurovascular integrity and stroke outcome
    Neurosciences Foundation
    2018 - 2019
     

Additional information

Editorial Board

  • 2016 - present: Frontiers in Neuropharmacology - Review Editor
  • 2015 - present: Frontiers in Cardiovascular Medicine: Cardiovascular Therapeutics - Editorial Board Member
  • 2015 - present: Frontiers in Pharmacology: Cardiovascular and Smooth Muscle Pharmacology - Review Editor
  • 2012 - 2013: ISRN Stroke - Editorial Board Member
  • 2011 - 2013: Journal of Geriatric Cardiology - Editorial Board Member

Grant Advisory Board

  • 2016 - present: Medical Research Council - Peer reviewer
  • 2011 - 2014: NHMRC - Postgraduate Scholarship Review Panel
  • 2011 - present: NHMRC - External Grant Assessor
  • 2011: Foundation for High Blood Pressure - Research Fellowship Reviewer

Prizes, Awards and Distinctions

  • 2009: International Society for Cerebral Blood Flow & Metabolism (ISCBFM) - Neils Lassen Award (2009)
  • 2006: British Pharmacological Society - Young Pharmacologist of the Year
  • 2006: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists (ASCEPT) - Dennis Wade Johnson & Johnson New Investigator Award (2006)
  • 2006: American Society of Pharmacology & Experimental Therapeutics (ASPET) - Postdoctoral Young Scientist Award

Professional Learned Society

  • 2015 - present: Brain & Brain-PET 2015, 2017 - Abstract reviewer
  • 2015: Australasian Society of Clinical and Experimental Pharmacologists & Toxicologist (ASCEPT) - Symposium organizer at the ASCEPT Annual Scientific Meeting
  • 2010 - 2011: Australasian Society of Clinical and Experimental Pharmacologists & Toxicologist (ASCEPT) - Committee member of the ASCEPT Scientific Advisory Board
  • 2009: Australasian Society of Clinical and Experimental Pharmacologists & Toxicologist (ASCEPT) - Symposium organizer of a joint symposium of ASCEPT and the Society for Free Radical Research
  • 2009 - 2013: International Society for Cerebral Blood Flow and Metabolism (ISCBFM) - Chair of the Young Investigators Committee
  • 2009 - 2013: Australia and New Zealand Microcirculation Society - Victorian Representative
  • 2008 - 2011: Australasian Society of Clinical and Experimental Pharmacologists & Toxicologist (ASCEPT) - Co-convenor of the ASCEPT Cardiovascular Special Interest Group
  • 2006 - 2012: American Society of Pharmacology and Experimental Therapeutics (ASPET) - Committe member - Division of Cardiovascular Pharmacology (Competition Committee)

Research Fellowship

  • 2013 - 2016: RMIT University - Vice-Chancellor's Senior Research Fellowship
  • 2009 - 2013: NHMRC - NHMRC Career Development Fellowship (Level 1)
  • 2007 - 2009: High Blood Pressure Research Council of Australia - Foundation for High Blood Pressure Research Post-doctoral Fellowship