Applied Pharmacogenomics & Molecular Medicine MED5382
- Academic Session: 2022-23
- School: School of Cardiovascular and Metabolic
- Credits: 10
- Level: Level 5 (SCQF level 11)
- Typically Offered: Semester 2
- Available to Visiting Students: No
- Available to Erasmus Students: No
This course provides students with in-depth knowledge on theoretical aspects, techniques, ethical considerations and applied translational examples of molecular medicine, gene therapy and pharmacogenomics.
Lectures weekly during the second semester.
MED5381 Pharmacogenomics & Molecular Medicine: Fundamentals of Molecular Medicine
Coursework (20%). An assignment focused on critical evaluation of the ethical issues associated with the use of patient genetic information.
Final written exam (80%).
Main Assessment In: April/May
This course aims to provide students with in-depth, critical understanding of the key and advanced concepts, principles and examples of:
■ The genetic basis of disease and variability in responses to drug treatment
■ Gene manipulation, transgenic animals and translational gene therapy
■ Ethical considerations in relation to genetic medicine
Intended Learning Outcomes of Course
By the end of this course students will be able to:
■ Critically evaluate theories and concepts of molecular pharmacogenomics and demonstrate how principles of molecular and cellular biology can be used to explain the genetic basis of variability in drug response.
■ Articulate the principles of translational pharmacogenetics and evaluate the ethical issues it raises in a range of specialised drug treatment techniques.
■ Identify and critically discuss the principles of gene therapy and how it has evolved from our understanding of the molecular basis of disease.
■ Critique different approaches in gene therapy to treat monogenic and complex diseases.
■ Explain gene editing technologies as tools for understanding gene function and as a therapeutic intervention.
■ Describe the production of genetically modified animal models and evaluate their use in the understanding of gene function.
Minimum Requirement for Award of Credits
Students must submit at least 75% by weight of the components (including examinations) of the course's summative assessment.