This course will build on the fundamentals of neuronal signalling and network signalling and introduce students to the concept of the flexible nature of synapses and neural networks under different behavioural, developmental or pathological circumstances. The course will explore the diverse range of neuromodulatory and synaptic plasticity mechanisms, outlining their importance for future neuroscience research.

This option is assigned to block S2-C. There is normally a 1-hour and a 2-hour session on a Thursday.

None

The course will be assessed by in-course assessment consisting of 2 components: a research/grant proposal (60%) and a video blog designed to support and justify the grant proposal (40%).

The aims of this option are: 

1. To enable students to develop an understanding of the flexible and plastic nature of the nervous system in the context of both physiological and pathophysiological function. 

2. To develop in students the ability to assimilate current knowledge in intrinsic neuromodulation and be able to apply that knowledge to future experimental and research design involving extrinsic neuromodulatory methods.

By the end of this course, students will be able to: 

■ Discuss the basis of neuromodulation and synaptic plasticity through a detailed knowledge of the underlying cellular mechanisms;

■ Evaluate mechanisms of synaptic plasticity and neuromodulation; 

■ Critically evaluate contemporary literature in this field and assimilate for the purpose of future experimental/research design;

■ Assess current experimental techniques and strategies in this area and evaluate approaches to experimental design;

■ Develop, discuss and justify novel research questions around the themes of neuromodulation and plasticity.