This course explores the broad range of neurotransmitters and neuromodulators that are active in the CNS, the ways in which clinically and experimentally used drugs interact with these molecules to alleviate CNS disorders and/or produce undesired effects, and emerging classes of drugs that interact with endogenous neurotransmitter systems. 

There are normally 3 hours of teaching on Fridays, which may be split over more than one session. 

None

The course will be assessed by a 2-hour examination (75%) and in-course assessment consisting of a single written assignment (25%).

This course aims to provide students with a detailed understanding of neurotransmission within the CNS and how drugs that modulate neurotransmitter function can be used to treat CNS disorders. 

By the end of this course, students will be able to:

■ Discuss the key proteins and processes that serve as drug targets in the CNS;

■ Assess the relative contributions of individual neuromodulators and neurotransmitter systems to the functioning of the CNS in health and disease;

■ Evaluate the mechanisms of action, efficacy and adverse effects of current experimental drugs and licensed medications and their utility in the exploration of CNS function and the treatment of CNS disorders;

■ Critically appraise the therapeutic potential that resides within individual neuromodulators and neurotransmitter systems in terms of future CNS drug development.