This course explores neural pathways underlying pain, nociception and itch. Cutting-edge research approaches in these areas will be taught, from RNA sequencing approaches, the use of transgenic animal models, through to clinical studies in patients. Developing new therapies for pain is challenging because of the complexity of the circuits underlying pain and nociception. This option will address the challenges of unravelling complex neuronal circuitry in the mammalian nervous system. 

This option is assigned to block S2-A. There is normally one 3-hour session on Mondays.

None.

The course will be assessed by a 2-hour written examination (70%) and in-course assessment (30%) consisting of a written assignment based on a published research article. The in-course assignment will be completed in class.

The aims of this option are twofold:

■ To explore current knowledge and research of neuronal pathways underlying pain, nociception and itch. 

■ To develop awareness of how experimental animal models inform clinical work, and how this knowledge translates to understanding and developing treatments.  

By the end of the course, students will be able to:

■ Discuss the arrangement of primary afferents, interneurons and projection neurons in the dorsal horn of the spinal cord;

■ Evaluate pain mechanisms, with particular reference to neuropathic pain;

■ Assess some of the current experimental strategies being used to promote regeneration and/or compensatory plastic changes in experimental models of pain and itch;

■ Appraise conceptual problems in chemical neuroanatomy;

■ Discuss the neurochemistry of circuits employing acetylcholine and monoamines.