Dr Emilie Combet Aspray

  • Lecturer in Nutrition (Human Nutrition)

telephone: 01412018527
email: Emilie.CombetAspray@glasgow.ac.uk

Research interests

Visit my Google Scholar page

My research is multi-disciplinary and focuses on how food (including whole foods, specific nutrients, and the way we eat) impacts on health throughout life, from the time peri-conception to old age. I have a particular interest on the “farm to fork to society” nexus, and its implications for all stakeholders, from a community, industry and clinical settings. It is a fascinating topic, since its implications are at the heart of the challenges faced by today’s modern society: ageing and chronic diseases.

Human nutrition is a body of integrated science, underpinning much of biomedical and health research, with broad implications for public health and related policies and commercial activities. Our research in Human Nutrition at Glasgow always aims to inform, and change, practice and policy. Impactful research is at the core of our activity.

Some  projects are industry-led, others funded by charities and governmental bodies. Most are applied, with wide public health implications.

 Current activities / research themes

  • Iodine and thyroid health – Iodine is key for infant brain development during pregnancy and the neonatal period. In the UK, there is no prophylaxis at the moment. Our projects investigate levels of iodine intake in the female population, in babies, to understand barriers, long-term implication of exposure to insufficient iodine, as well as possible solutions to this public health issue. We have developed and validated a short food frequency questionnaire for iodine. It is available here and validated there .
  • Polyphenol intake and metabolism (inflammation, ageing, immune senescence) – Polyphenols are bioactive present in all plant foods. While their bioavailability is low, there is increasing evidence that their metabolism in the colon is implicated in their bioactivity. Polyphenol metabolites are likely to impact on the gut microbiota, and to impact the antigenic load of an individual. We study polyphenol metabolism, and its impact on lifelong health via the measurement of key biomarkers (including phenolic acids) in plasma and urine. Studies involve healthy volunteers, frail / healthy older adults, individuals at risk of colorectal cancer and colorectal cancer patients.
  • Oxidative/nitrosative stress, nutrition, glycation and ageing – Dietary compounds with antioxidant activity have been studied in the context of the free radical theory of ageing. Dietary bioactives, including polyphenol and their metabolites impact on oxidative/nitrosative stress as well as glycation. However, their mode of action is complex and involves more than free radical scavenging. We are using physiologically –relevant benchtop models to model these reactions. Focussing on dietary assessment and measurement of biomarkers in cohort studies, we study the contribution of glycated molecules, ROS/RNS to inflammation, pathogenesis in the context of obesity and the ageing process.
  • Food nutritional quality, reformulation – Several projects focus on food quality, from specific nutrients, bioactives (using our analytical platform) to food reformulation (and its potential / implications), improving the nutritional balance of food products. Previous and current projects have focused on coffee, seaweed, honey bee products, olive oil, fruit juices, and the nutritionally balanced pizza.

 

 Research methods

  • Analytical biochemistry (state-of-the-art liquid / gas chromotography and mass spectrometry) with emphasis on bioactive profiling in foods (polyphenolics), biomarkers of colonic metabolism (phenolic acids) and oxidation/glycation/inflammation (Advanced Glycation End-products)
  • Intervention studies, including short-term acute feeding studies to study bioavailability and medium term feeding studies
  • Cross-sectional surveys in the clinic and community, focussing on exposure to key dietary compounds (polyphenolics, iodine) in relation to metabolic health or awareness, knowledge and practice related to nutrition.

 We focus on collaborative research, as a way to deliver projects with a wide range of implications and stakeholders. Current PhD candidates and research assistants come from a diverse academic and clinical background, and from several countries, adding the multidisciplinarity of the lab. Prospective students are invited to get in touch by email first.

 Collaboration

I am a Scottish Crucible alumnus (2011) and have active collaborations with colleagues in Europe and beyond, on the following key themes “Healthy Mothers Matters –nutrition, maternal & infant health” and “Nutrition, inflammation and ageing

 Public engagement and social media

I am a STEM ambassador, and have also contributed to the “I’m a scientist, get me out of here” initiative, in the Hungry Zone.

My tweeter account is @emiliecombet

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Iodine status and thyroid function in Scottish neonates; relationship with maternal iodine intake.
    Yorkhill Children's Foundation
    2014 - 2016
     
  • Bioavailability of Olive Oil phenolics and impact of high olive oil consumption on proteomic markers
    University of Lisbon
    2012 - 2014
     
  • Seaweed as a dietary supplement to address iodine deficiency in UK females: a feasibility study
    Technology Strategy Board (TSB)
    2012 - 2012
     
  • 'Nutritional Care of People Affected by Cancer' Education Programme Evaluation
    MacMillan Cancer Support
    2010 - 2011
     
  • A novel benchtop model to simultaneously study the impact of dietary polyphenols on colonic microbiota and enterocytes
    Royal Society
    2010 - 2011
     
  • Inter-individual variations in the colonic metabolism of flavonols
    Tenovus-Scotland
    2010 - 2012
     
  • Prevalence of low and marginal iodine status in women of child-bearing age and influence of goitrogen-rich food intake
    Yorkhill Children's Foundation
    2010 - 2011
     

Teaching

Teaching

My research informs my teaching, on the MSc in Human Nutrition, mainly on the “Food and Nutrition through the lifecycle” and “Digestion, absorption and metabolism” courses.

I am specialisation leader for aResearch Methodology course on the MSc Translational Medical Sciences, focussing on biochemical and metabolic research. 

Publications

List by: Type | Date

Jump to: 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2007
Number of items: 23.

2014

Vlassopoulos, A., Combet , E., and Lean, M. (2014) Changing distributions of body size and adiposity with age. International Journal of Obesity, 38 (6). pp. 857-864. ISSN 0307-0565 (doi:10.1038/ijo.2013.216)

Silva, S., Bronze, M. R., Figueira, M. E., Siwy, J., Mischak, H., Combet, E., and Mullen, W. (2014) Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study. American Journal of Clinical Nutrition . ISSN 0002-9165 (doi:10.3945/​ajcn.114.094219) (Early Online Publication)

Combet, E., and Lean, M.E.J. (2014) Validation of a short food frequency questionnaire specific for iodine in UK females of childbearing age. Journal of Human Nutrition and Dietetics . ISSN 0952-3871 (doi:10.1111/jhn.12219) (Early Online Publication)

Combet, E., Jarlot, A., Aidoo, K. E., and Lean, M. E. J. (2014) Development of a nutritionally balanced pizza as a functional meal designed to meet published dietary guidelines. Public Health Nutrition . pp. 1-10. ISSN 1368-9800 (doi:10.1017/S1368980013002814) (Early Online Publication)

Combet, E., Ma, Z. F., Cousins, F., Thompson, B., and Lean, M. E. J. (2014) Low-level seaweed supplementation improves iodine status in iodine-insufficient women. British Journal of Nutrition, 112 (5). pp. 753-761. ISSN 0007-1145 (doi:10.1017/S0007114514001573)

Shahzad, M., Sherry, L., Rajendran, R., Edwards, C. A., Combet, E., and Ramage, G. (2014) Utilising polyphenols for the clinical management of Candida albicans biofilms. International Journal of Antimicrobial Agents , 44 (3). pp. 269-273. ISSN 0924-8579 (doi:10.1016/j.ijantimicag.2014.05.017)

Vlassopoulos, A., Lean, M.E.J., and Combet, E. (2014) Protein–phenolic interactions and inhibition of glycation – combining a systematic review and experimental models for enhanced physiological relevance. Food and Function, 5 (10). pp. 2646-2655. ISSN 2042-6496 (doi:10.1039/C4FO00568F)

Vlassopoulos, A., Lean, M. E. J., and Combet, E. (2014) Oxidative stress, protein glycation and nutrition – interactions relevant to health and disease throughout the lifecycle. Proceedings of the Nutrition Society, 73 (3). pp. 430-438. ISSN 0029-6651 (doi:10.1017/S0029665114000603)

2013

Hernández, M., Wilson, K.L., Combet, E., and Wardlaw, J.M. (2013) Brain findings associated with iodine deficiency identified by magnetic resonance methods: a systematic review. Open Journal of Radiology, 3 (4). pp. 180-195. ISSN 2164-3024 (doi:10.4236/ojrad.2013.34030)

Vlassopoulos, A., Lean, M.E.J., and Combet, E. (2013) Role of oxidative stress in physiological albumin glycation: a neglected interaction. Free Radical Biology and Medicine, 60 . pp. 318-324. ISSN 0891-5849 (doi:10.1016/j.freeradbiomed.2013.03.010)

Lean, M.I.F.A., Lean, M.E.J., Yajnik, C.S., Bhat, D., Joshi, S.M., Raut, D.A., Lubree, H.G., and Combet, E. (2013) Iodine status during pregnancy in India and related neonatal and infant outcomes. Public Health Nutrition . ISSN 1368-9800 (doi:10.1017/S1368980013001201 )

Mullen, W., Nemzer, B., Stalmach, A., Sidrah, A., and Combet, E. (2013) The polyphenolic and hydroxycinnamate contents of whole coffee fruits from China, India and Mexico. Journal of Agricultural and Food Chemistry, 61 (22). pp. 5298-5309. ISSN 0021-8561 (doi:10.1021/jf4003126)

Vlassopoulos, A., Lean, M.E.J., and Combet, E. (2013) Influence of smoking and diet on glycated haemoglobin and 'pre-diabetes' categorisation: a cross-sectional analysis. BMC Public Health, 13 (1013). ISSN 1471-2458 (doi:10.1186/1471-2458-13-1013)

2012

Garcia, A.L., Combet, E., Gerasimidis, K., Provan, D., and Edwards, C.A. (2012) Evaluation of an on-line educational programme: nutritional care of people affected by cancer. Proceedings of the Nutrition Society, 71 (OCE2). ISSN 0029-6651 (doi:10.1017/S0029665112002650)

Edwards, C., Garcia, A., and Combet, E. (2012) Colonic metabolism of bioactive molecules; potential impact of dietary fiber. In: Cho, S. and Almeida, N. (eds.) Dietary Fiber and Health. CRC Press, Boca Raton, FL, pp. 209-234. ISBN 9781439899298

2011

Combet, E., Lean, M.E.J., Boyle, J.G., Crozier, A., and Davidson, D.F. (2011) Dietary flavonols contribute to false-positive elevation of homovanillic acid, a marker of catecholamine-secreting tumours. Clinica Chimica Acta, 412 (1-2). pp. 165-169. ISSN 0009-8981 (doi:10.1016/j.cca.2010.09.037)

Mullen, W., Nemzer, B., Ou, B., Stalmach, A., Hunter, J., Clifford, M.N., and Combet, E. (2011) The antioxidant and chlorogenic acid profiles of whole coffee fruits are influenced by the extraction procedures. Journal of Agricultural and Food Chemistry, 59 (8). pp. 3754-3762. ISSN 0021-8561 (doi:10.1021/jf200122m)

2010

Combet, E., El Mesmari, A., Preston, T., Crozier, A., and McColl, K.E.L. (2010) Dietary phenolic acids and ascorbic acid: influence on acid-catalyzed nitrosative chemistry in the presence and absence of lipids. Free Radical Biology and Medicine, 48 (6). pp. 763-771. ISSN 0891-5849 (doi:10.1016/j.freeradbiomed.2009.12.011)

Combet, E., Preston, T., and McColl, K. (2010) Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation. Rapid Communications in Mass Spectrometry, 24 (5). pp. 529-534. ISSN 0951-4198 (doi:10.1002/rcm.4388)

Larbi, A., Cabreiro, F., Zelba, H., Marthandan, S., Combet, E., Friguet, B., Petropoulos, I., Barnett, Y., and Pawelec, G. (2010) Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation. Free Radical Biology and Medicine, 48 (1). pp. 26-34. ISSN 0891-5849 (doi:10.1016/j.freeradbiomed.2009.09.025)

2009

Combet, E., Henderson, J., Eastwood, D.C., and Burton, K.S. (2009) Influence of Sporophore Development, Damage, Storage, and Tissue Specificity on the Enzymic Formation of Volatiles in Mushrooms (Agaricus bisporus). Journal of Agricultural and Food Chemistry, 57 (9). pp. 3709-3717. ISSN 0021-8561

Larbi, A., Combet, E., Pawelec, G., and Fulop, T. (2009) Effect of intrinsic and extrinsic lipids on T-cell signalling. In: Fulop, T. (ed.) Handbook on Immunosenescence. Springer, p. 1437. ISBN 9781402090622

2007

Combet, E., Paterson, S., Iijima, K., Winter, J., Mullen, W., Crozier, A., Preston, T., and McColl, K.E.L. (2007) Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation. Gut, 56 . pp. 1678-1684. ISSN 0017-5749 (doi:10.1136/gut.2007.128587)

This list was generated on Sun Nov 23 10:20:42 2014 GMT.
Number of items: 23.

Articles

Vlassopoulos, A., Combet , E., and Lean, M. (2014) Changing distributions of body size and adiposity with age. International Journal of Obesity, 38 (6). pp. 857-864. ISSN 0307-0565 (doi:10.1038/ijo.2013.216)

Silva, S., Bronze, M. R., Figueira, M. E., Siwy, J., Mischak, H., Combet, E., and Mullen, W. (2014) Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study. American Journal of Clinical Nutrition . ISSN 0002-9165 (doi:10.3945/​ajcn.114.094219) (Early Online Publication)

Combet, E., and Lean, M.E.J. (2014) Validation of a short food frequency questionnaire specific for iodine in UK females of childbearing age. Journal of Human Nutrition and Dietetics . ISSN 0952-3871 (doi:10.1111/jhn.12219) (Early Online Publication)

Combet, E., Jarlot, A., Aidoo, K. E., and Lean, M. E. J. (2014) Development of a nutritionally balanced pizza as a functional meal designed to meet published dietary guidelines. Public Health Nutrition . pp. 1-10. ISSN 1368-9800 (doi:10.1017/S1368980013002814) (Early Online Publication)

Combet, E., Ma, Z. F., Cousins, F., Thompson, B., and Lean, M. E. J. (2014) Low-level seaweed supplementation improves iodine status in iodine-insufficient women. British Journal of Nutrition, 112 (5). pp. 753-761. ISSN 0007-1145 (doi:10.1017/S0007114514001573)

Shahzad, M., Sherry, L., Rajendran, R., Edwards, C. A., Combet, E., and Ramage, G. (2014) Utilising polyphenols for the clinical management of Candida albicans biofilms. International Journal of Antimicrobial Agents , 44 (3). pp. 269-273. ISSN 0924-8579 (doi:10.1016/j.ijantimicag.2014.05.017)

Vlassopoulos, A., Lean, M.E.J., and Combet, E. (2014) Protein–phenolic interactions and inhibition of glycation – combining a systematic review and experimental models for enhanced physiological relevance. Food and Function, 5 (10). pp. 2646-2655. ISSN 2042-6496 (doi:10.1039/C4FO00568F)

Vlassopoulos, A., Lean, M. E. J., and Combet, E. (2014) Oxidative stress, protein glycation and nutrition – interactions relevant to health and disease throughout the lifecycle. Proceedings of the Nutrition Society, 73 (3). pp. 430-438. ISSN 0029-6651 (doi:10.1017/S0029665114000603)

Hernández, M., Wilson, K.L., Combet, E., and Wardlaw, J.M. (2013) Brain findings associated with iodine deficiency identified by magnetic resonance methods: a systematic review. Open Journal of Radiology, 3 (4). pp. 180-195. ISSN 2164-3024 (doi:10.4236/ojrad.2013.34030)

Vlassopoulos, A., Lean, M.E.J., and Combet, E. (2013) Role of oxidative stress in physiological albumin glycation: a neglected interaction. Free Radical Biology and Medicine, 60 . pp. 318-324. ISSN 0891-5849 (doi:10.1016/j.freeradbiomed.2013.03.010)

Lean, M.I.F.A., Lean, M.E.J., Yajnik, C.S., Bhat, D., Joshi, S.M., Raut, D.A., Lubree, H.G., and Combet, E. (2013) Iodine status during pregnancy in India and related neonatal and infant outcomes. Public Health Nutrition . ISSN 1368-9800 (doi:10.1017/S1368980013001201 )

Mullen, W., Nemzer, B., Stalmach, A., Sidrah, A., and Combet, E. (2013) The polyphenolic and hydroxycinnamate contents of whole coffee fruits from China, India and Mexico. Journal of Agricultural and Food Chemistry, 61 (22). pp. 5298-5309. ISSN 0021-8561 (doi:10.1021/jf4003126)

Vlassopoulos, A., Lean, M.E.J., and Combet, E. (2013) Influence of smoking and diet on glycated haemoglobin and 'pre-diabetes' categorisation: a cross-sectional analysis. BMC Public Health, 13 (1013). ISSN 1471-2458 (doi:10.1186/1471-2458-13-1013)

Garcia, A.L., Combet, E., Gerasimidis, K., Provan, D., and Edwards, C.A. (2012) Evaluation of an on-line educational programme: nutritional care of people affected by cancer. Proceedings of the Nutrition Society, 71 (OCE2). ISSN 0029-6651 (doi:10.1017/S0029665112002650)

Combet, E., Lean, M.E.J., Boyle, J.G., Crozier, A., and Davidson, D.F. (2011) Dietary flavonols contribute to false-positive elevation of homovanillic acid, a marker of catecholamine-secreting tumours. Clinica Chimica Acta, 412 (1-2). pp. 165-169. ISSN 0009-8981 (doi:10.1016/j.cca.2010.09.037)

Mullen, W., Nemzer, B., Ou, B., Stalmach, A., Hunter, J., Clifford, M.N., and Combet, E. (2011) The antioxidant and chlorogenic acid profiles of whole coffee fruits are influenced by the extraction procedures. Journal of Agricultural and Food Chemistry, 59 (8). pp. 3754-3762. ISSN 0021-8561 (doi:10.1021/jf200122m)

Combet, E., El Mesmari, A., Preston, T., Crozier, A., and McColl, K.E.L. (2010) Dietary phenolic acids and ascorbic acid: influence on acid-catalyzed nitrosative chemistry in the presence and absence of lipids. Free Radical Biology and Medicine, 48 (6). pp. 763-771. ISSN 0891-5849 (doi:10.1016/j.freeradbiomed.2009.12.011)

Combet, E., Preston, T., and McColl, K. (2010) Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation. Rapid Communications in Mass Spectrometry, 24 (5). pp. 529-534. ISSN 0951-4198 (doi:10.1002/rcm.4388)

Larbi, A., Cabreiro, F., Zelba, H., Marthandan, S., Combet, E., Friguet, B., Petropoulos, I., Barnett, Y., and Pawelec, G. (2010) Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation. Free Radical Biology and Medicine, 48 (1). pp. 26-34. ISSN 0891-5849 (doi:10.1016/j.freeradbiomed.2009.09.025)

Combet, E., Henderson, J., Eastwood, D.C., and Burton, K.S. (2009) Influence of Sporophore Development, Damage, Storage, and Tissue Specificity on the Enzymic Formation of Volatiles in Mushrooms (Agaricus bisporus). Journal of Agricultural and Food Chemistry, 57 (9). pp. 3709-3717. ISSN 0021-8561

Combet, E., Paterson, S., Iijima, K., Winter, J., Mullen, W., Crozier, A., Preston, T., and McColl, K.E.L. (2007) Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation. Gut, 56 . pp. 1678-1684. ISSN 0017-5749 (doi:10.1136/gut.2007.128587)

Book Sections

Edwards, C., Garcia, A., and Combet, E. (2012) Colonic metabolism of bioactive molecules; potential impact of dietary fiber. In: Cho, S. and Almeida, N. (eds.) Dietary Fiber and Health. CRC Press, Boca Raton, FL, pp. 209-234. ISBN 9781439899298

Larbi, A., Combet, E., Pawelec, G., and Fulop, T. (2009) Effect of intrinsic and extrinsic lipids on T-cell signalling. In: Fulop, T. (ed.) Handbook on Immunosenescence. Springer, p. 1437. ISBN 9781402090622

This list was generated on Sun Nov 23 10:20:42 2014 GMT.