Dr Christian Delles

- Reader (Institute of Cardiovascular and Medical Sciences)
telephone: 3302749
email: Christian.Delles@glasgow.ac.uk
Christian studied medicine at the Universities of Freiburg, Germany, and Innsbruck, Austria. He undertook his MD research in Prof. Paul Dietl's lab at the Department of Physiology in Innsbruck and joined Prof. Roland Schmieder's group at the Department of Nephrology, University of Erlangen-Nürnberg, in 1997. Here he worked on renal haemodynamics in arterial hypertension, type 2 diabetes, and other diseases; pathophysiology of endothelial dysfunction; and pathophysiology of left ventricular hypertrophy. In parallel he completed his specialist training in Internal Medicine. He joined BHF GCRC in 2003 as a Research Fellow funded by the Deutsche Forschungsgemeinschaft and holds a Senior Lectureship since 2005. His main focus is on the role of oxidative stress in the development of human cardiovascular disease, genetics of hypertension, and vascular phenotyping including measures of endothelial dysfunction and vascular stiffness.
Research:
Theme:
2013
Baker, A.H., and Delles, C. (2013) Is microRNA-376c a biomarker or mediator of preeclampsia? Hypertension, 61 (4). pp. 767-769. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.111.00087)
Bryce, G.J., Payne, C.J., Gibson, S.C., Byrne, D.S., Delles, C., McClure, J.D., and Kingsmore, D. (2013) B-type natriuretic peptide predicts postoperative cardiac events and mortality after elective open abdominal aortic aneurysm repair. Journal of Vascular Surgery, 57 (2). pp. 345-353. ISSN 0741-5214 (doi:10.1016/j.jvs.2012.07.053)
2012
Chick, H.E. et al. (2012) Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk. Human Gene Therapy, 23 (12). pp. 1247-1257. ISSN 1043-0342 (doi:10.1089/hum.2012.042)
Mackenzie, R.M., Sandrim, V.C., Carty, D.M., McClure, J.D., Freeman, D.J., Dominiczak, A.F., McBride, M.W., and Delles, C. (2012) Endothelial FOS expression and pre-eclampsia. BJOG: An International Journal of Obstetrics and Gynaecology, 119 (13). pp. 1564-1571. ISSN 1470-0328 (doi:10.1111/1471-0528.12016)
Asselbergs, F.W. et al. (2012) Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. American Journal of Human Genetics, 91 (5). pp. 823-838. ISSN 0002-9297 (doi:10.1016/j.ajhg.2012.08.032)
Hocking, L.J. et al. (2012) Heritability of chronic pain in 2195 extended families. European Journal of Pain, 16 (7). pp. 1053-1063. ISSN 1090-3801 (doi:10.1002/j.1532-2149.2011.00095.x)
Bryce, G.J., Payne, C.J., Gibson, S.C., Kingsmore, D.B., Byrne, D.S., and Delles, C. (2012) Risk stratification scores in elective open abdominal aortic aneurysm repair: are they suitable for preoperative decision making? European Journal of Vascular and Endovascular Surgery, 44 (1). pp. 55-61. ISSN 1078-5884 (doi:10.1016/j.ejvs.2012.03.021)
Delles, C., Neisius, U., and Carty, D.M. (2012) Proteomics in hypertension and other cardiovascular diseases. Annals of Medicine, 44 (S1). S55-S64. ISSN 0785-3890 (doi:10.3109/07853890.2012.660494)
Carty, D.M., Anderson, L.A., Freeman, D.J., Welsh, P.I., Brennand, J.E., Dominiczak, A.F., and Delles, C. (2012) Early pregnancy soluble E-selectin concentrations and risk of preeclampsia. Journal of Hypertension, 30 (5). pp. 954-959. ISSN 0263-6352 (doi:10.1097/HJH.0b013e328352573b)
Carty, D.M., Anderson, L.A., Duncan, C.N., Baird, D., Rooney, L.K., Dominiczak, A.F., and Delles, C. (2012) Peripheral arterial tone: assessment of microcirculatory function in pregnancy. Journal of Hypertension, 30 (1). pp. 117-123. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32834d76fb)
Dawson, J., Walters, M., Delles, C., Mischak, H., and Mullen, W. (2012) Urinary proteomics to support diagnosis of stroke. PLoS ONE, 7 (5). e35879. ISSN 1932-6203 (doi:10.1371/journal.pone.0035879)
Delles, C., and Padmanabhan, S. (2012) Genetics and hypertension: is it time to change my practice? Canadian Journal of Cardiology, 28 (3). pp. 296-304. ISSN 0828-282X (doi:10.1016/j.cjca.2012.02.004)
Kane, N.M. et al. (2012) Role of MicroRNAs 99b, 181a, and 181b in the differentiation of human embryonic stem cells to vascular endothelial cells. Stem Cells, 30 (4). pp. 643-654. ISSN 1066-5099 (doi:10.1002/stem.1026)
Mullen, W., Gonzalez, J., Siwy, J., Franke, J., Sattar, N., Mullan, A., Roberts, S., Delles, C., Mischak, H., and Albalat, A. (2012) A pilot study on the effect of short-term consumption of a polyphenol rich drink on biomarkers of coronary artery disease defined by urinary proteomics. Journal of Agricultural and Food Chemistry, 59 (24). pp. 12850-12857. ISSN 0021-8561 (doi:10.1021/jf203369r)
Neisius, U. et al. (2012) Association of central and peripheral pulse pressure with intermediate cardiovascular phenoytpes. Journal of Hypertension, 30 (1). pp. 67-74. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32834e12d8)
Neisius, U., Schneider, M.P., and Delles, C. (2012) Association of central and peripheral pulse pressure with intermediate cardiovascular phenotypes Reply. Journal of Hypertension, 30 (4). p. 835. ISSN 0263-6352 (doi:10.1097/HJH.0b013e328350e57c)
2011
Johnson, T. et al. (2011) Blood pressure loci identified with a gene-centric array. American Journal of Human Genetics, 89 (6). pp. 688-700. ISSN 0002-9297 (doi:10.1016/j.ajhg.2011.10.013)
Delles, C., Diez, J., and Dominiczak, A.F. (2011) Urinary proteomics in cardiovascular disease: achievements, limits and hopes. Proteomics Clinical Applications, 5 (5-6). pp. 222-232. ISSN 1862-8346 (doi:10.1002/prca.201000125)
Ott, C., Schneider, M.P., Delles, C., Schlaich, M.P., Hilgers, K.F., and Schmieder, R.E. (2011) Association of (pro)renin receptor gene polymorphism with blood pressure in Caucasian men. Pharmacogenetics and Genomics, 21 (6). pp. 347-349. ISSN 1744-6872 (doi:10.1097/FPC.0b013e328344cdd2)
McQuarrie, E.P., Patel, R.K., Mark, P.B., Delles, C., Connell, J., Dargie, H.J., Steedman, T., and Jardine, A.G. (2011) Association between proteinuria and left ventricular mass index: a cardiac MRI study in patients with chronic kidney disease. Nephrology, Dialysis, Transplantation, 26 (3). pp. 933-938. ISSN 0931-0509 (doi:10.1093/ndt/gfq418)
Lanktree, Matthew B et al. (2011) Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics, 88 (1). pp. 6-18. ISSN 0002-9297 (doi:10.1016/j.ajhg.2010.11.007 )
Carty, D.M. et al. (2011) Urinary proteomics for prediction of preeclampsia. Hypertension, 57 (3). pp. 561-569. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.110.164285)
Mullen, W., Delles, C., and Mischak, H. (2011) Urinary proteomics in the assessment of chronic kidney disease. Current Opinion in Nephrology and Hypertension, 20 (6). pp. 654-661. ISSN 1062-4821 (doi:10.1097/MNH.0b013e32834b7ffa)
Ott, C., Schneider, M. P., Delles, C., Schlaich, M. P., and Schmieder, R. E. (2011) Reduction in Basal Nitric Oxide Activity Causes Albuminuria. Diabetes, 60 (2). pp. 572-576. ISSN 0012-1797 (doi:10.2337/db09-1630)
Stevens, K.K., Morgan, I.R., Patel, R.K., Geddes, C.C., Mark, P.B., Jardine, A.G., and Delles, C. (2011) Serum phosphate and outcome at one year after deceased donor renal transplantation. Clinical Transplantation, 25 (2). E199-E204. ISSN 0902-0063 (doi:10.1111/j.1399-0012.2011.01400.x)
2010
Carty, D.M., Delles, C., and Dominiczak, A.F. (2010) Preeclampsia and future maternal health. Journal of Hypertension, 28 (7). pp. 1349-1355. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32833a39d0)
Delles, C. (2010) Angiotensinogen, birth weight and diabetes: will genetics provide a link? Journal of Hypertension, 28 (4). pp. 665-667. ISSN 0263-6352 (doi:10.1097/HJH.0b013e328337f524 Univ Glasgow, BHF Glasgow Cardiovasc Res Ctr, Glasgow G12 8TA, Lanark, Scotland.)
Delles, C., Dymott, J.A., Neisius, U., Rocchiccioli, J.P., Bryce, G.J., Moreno Zulategui, M.U., Carty, D.M., Berg, G.A., Hamilton, C.A., and Dominiczak, A.F. (2010) Reduced LDL-cholesterol levels in patients with coronary artery disease are paralelled by improved endothelial function: An observational study in patients from 2003 and 2007. Atherosclerosis, 211 (1). pp. 271-277. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2010.01.014)
Delles, C., and Jardine, A.G. (2010) Renal function and cardiovascular events: relevance of eGFR and albuminuria in patients with diabetes. Diabetologia, 54 (1). pp. 4-6. ISSN 0012-186X (doi:10.1007/s00125-010-1942-2)
Delles, C., McBride, M.W., Graham, D., Padmanabhan, S., and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802 (12). pp. 1299-1308. ISSN 0925-4439 (doi:10.1016/j.bbadis.2009.12.006)
Delles, C. et al. (2010) Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals. Journal of Hypertension, 28 (11). pp. 2316-2322. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32833d81b7)
Dominiczak, A. F. et al. (2010) Systems biology to battle vascular disease. Nephrology, Dialysis, Transplantation, 25 (4). pp. 1019-1022. ISSN 0931-0509 (doi:10.1093/ndt/gfq025)
Fadini, G.P. et al. (2010) Urinary collagen fragments are significantly altered in diabetes: a link to pathophysiology. PLoS ONE, 5 (9). e13051. ISSN 1932-6203 (doi:10.1371/journal.pone.0013051)
Good, D. M. et al. (2010) Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease. Molecular and Cellular Proteomics, 9 (11). pp. 2424-2437. ISSN 1535-9476 (doi:10.1074/mcp.M110.001917)
Mischak, H., Delles, C., Klein, J., and Schanstra, J.P. (2010) Urinary Proteomics Based on Capillary Electrophoresis-Coupled Mass Spectrometry in Kidney Disease: Discovery and Validation of Biomarkers, and Clinical Application. Advances in Chronic Kidney Disease, 17 (6). pp. 493-506. ISSN 15485595 (doi:10.1053/j.ackd.2010.09.004)
Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6 (10). e1001177. ISSN 1553-7390 (doi:10.1371/journal.pgen.1001177)
Padmanabhan, S. et al. (2010) The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study. Journal of Hypertension, 28 (3). pp. 465-477. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32833594d7)
Taurino, C., Miller, W.H., McBride, M.W., McClure, J.D., Khanin, R., Moreno Zulategui, M.U., Dymott, J., Delles, C., and Dominiczak, A.F. (2010) Gene expression profiling in whole blood of patients with coronary artery disease. Clinical Science, 119 (8). pp. 335-343. ISSN 0143-5221 (doi:10.1042/CS20100043)
2009
Talmud, PJ et al. (2009) Gene-centric association signals for lipids and apolipoproteins identified via the humanCVD BeadChip. American Journal of Human Genetics, 85 (5). pp. 628-642. ISSN 0002-9297 (doi:10.1016/j.ajhg.2009.10.014)
Dominiczak, A. F., Delles, C, and Padmanabhan, S (2009) Are isolated populations better for studying genes that predispose to hypertension? Journal of Hypertension, 27 (5). pp. 939-940.
2008
Delles, C. (2008) Risk factors and target organ damage: is there a special case for prehypertension? Journal of Hypertension, 26 (12). pp. 2268-2270. ISSN 0263-6352 (doi:10.1097/HJH.0b013e328317f039)
Delles, C., McBride, M.W., Padmanabhan, S., and Dominiczak, A.F. (2008) The genetics of cardiovascular disease. Trends in Endocrinology and Metabolism, 19 (9). pp. 309-316. ISSN 1043-2760 (doi:10.1016/j.tem.2008.07.010 )
Delles, C., Raff, U., Mimran, A., Fauvel, J.P., Ruilope, L.M., and Schmieder, R.E. (2008) Effects of telmisartan and ramipril on adiponectin and blood pressure in patients with type 2 diabetes. American Journal of Hypertension, 21 (12). pp. 1330-1336. ISSN 1941-7225 (doi:10.1038/ajh.2008.297)
Jantos-Siwy, J., Schiffer, E., Brand, K., Schumann, G., Rossing, K., Delles, C., Mischak, H., and Metzger, E. (2008) Quantitative urinary proteome analysis for biomarker evaluation in chronic kidney disease. Journal of Proteome Research, 8 (1). pp. 268-281. ISSN 1535-3893 (doi:10.1021/pr800401m)
Ritt, M., Ott, C., Delles, C., Schneider, M.P., and Schmieder, R.E. (2008) Impact of the endothelial nitric oxide synthase gene G894T polymorphism on renal endothelial function in patients with type 2 diabetes. Pharmacogenetics and Genomics, 18 (8). pp. 699-707. ISSN 1744-6872
Berry, C., Zimmerli, L.U., Steedman, T., Foster, J.E., Dargie, H.J., Berg, H.A., Dominiczak, A.F., and Delles, C. (2008) Cardiac magnetic resonance findings predict increased resource utilization in elective coronary artery bypass grafting. Clinical Science, 114 (6). pp. 423-430. ISSN 0140-8736 (doi:10.1042/CS20070337)
Carty, D, Delles, C, and Dominiczak, AF (2008) Novel Biomarkers for Predicting Preeclampsia. Trends in Cardiovascular Medicine, 18 (5). pp. 186-194. ISSN 1050-1738 (doi:10.1016/j.tcm.2008.07.002)
Delles, C (2008) Candidate gene studies in cardiovascular medicine: complex diseases and even more complex intermediate phenotypes. Journal of Hypertension, 26 (6). pp. 1069-1071. ISSN 0263-6352
Delles, C, Miller, W. H., and Dominiczak, A. F. (2008) Targeting reactive oxygen species in hypertension. Antioxidants and Redox Signaling, 10 (6). pp. 1061-1077. ISSN 1523-0864 (doi:10.1089/ars.2007.2008 )
Delles, C, Neisius, U, Dymott, JA, Carty, D, Rocchiccioli, JP, Bryce, GJ, Berg, GA, Hamilton, CA, and Dominiczak, AF (2008) Strategies to target cholesterol levels lead to improved endothelial function in patients with coronary artery disease (CAD). Journal of Hypertension, 26 . S325-S325. ISSN 0263-6352
Delles, C et al. (2008) Glutathione S-transferase variants and hypertension. Journal of Hypertension, 26 (7). pp. 1343-1352. ISSN 0263-6352 (doi:10.1097/HJH.0b013e3282fe1d67)
Dymott, J.A., Chow, C., Rocchiccioli, J.P., Berg, G.A., Cherry, A.K.L., Delles, C., Hamilton, C.A., and Dominiczak, A.F. (2008) Endothelial function in patients undergoing coronary artery by-pass grafting is improved in patients in 2006 compared to 2003. Scottish Medical Journal , 53 (1). p. 57. ISSN 0036-9330
Moreno, MU, Dymott, J, Taurino, C, Berg, G, Carty, D, Mc Culloch, J, Delles, C, and Dominiczak, AF (2008) Whole blood and mononuclear cell superoxide generation are increased in patients with coronary artery disease. Journal of Hypertension, 26 . S308-S308.
Moreno, MU, Dymott, J, Taurino, C, Carty, D, Mc Culloch, J, Delles, C, and Dominiczak, AF (2008) Exercise attenuates superoxide release in whole blood and mononuclear cells in patients with coronary artery disease. Journal of Hypertension, 26 . S320-S320.
Padmanabhan, S, Melander, O, Hastie, C, Menni, C, Delles, C, Connell, J, and Dominiczak, AF (2008) Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols. Journal of Hypertension, 26 (7). pp. 1275-1281.
Zimmerli, L.U. et al. (2008) Urinary proteomic biomarkers on coronary artery disease. Molecular and Cellular Proteomics, 7 (2). pp. 290-298. ISSN 1535-9476 (doi:10.1074/mcp.M700394-MCP200)
Zulategui, MUM, Dymott, JA, Taurino, C, Berg, GA, Rocchiccioli, JP, Delles, C, and Dominiczak, AF (2008) Superoxide release by whole blood and mononuclear cells as markers of oxidative stress in patients with coronary artery disease. Journal of Human Hypertension, 22 (10). p. 733.
de Ujue, M, Zulategui, M, Dymott, JA, Taurino, C, Berg, GA, Rocchiccioli, P, Delles, C, and Dominiczak, AF (2008) Relationship between whole blood and mononuclear cell superoxide levels in patients with coronary artery disease. Hypertension, 52 (4). E55-E56. ISSN 0194-911X
2007
Delles, C (2007) Mitochondria, maternal transmission and hypertension. Journal of Hypertension, 25 (10). pp. 2001-2003.
Delles, C (2007) Vascular function in rheumatoid arthritis: intermediate phenotypes and cardiovascular risk. Journal of Hypertension, 25 (6). pp. 1195-1196.
Delles, C, Fauvel, JP, Mimran, A, Ruilope, LM, and Schmieder, RE (2007) Impact of telmisartan versus ramipri on ronal endothelial function in patients with hypertension and type 2 diabetes. Diabetes Care, 30 (6). pp. 1351-1356.
Delles, C, Schlaich, MP, and Schmieder, RE (2007) Involvement of endothelial mechanisms in L-arginine-induced alterations of renal haemodynamics in humans. Journal of Hypertension, 25 (7). pp. 1515-1516.
Schlaich, M.P., Oehmer, S., Schneider, M.P., Delles, C., Schmidt, B.M.W., and Schmieder, R.E. (2007) Effects of nitric oxide synthase inhibition and L-arginine on renal haemodynamics in young patients at high cardiovascular risk. Atherosclerosis, 192 (1). pp. 155-160. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2006.04.025)
Zimmerli, LU, Mark, PB, Steedman, T, Foster, JE, Berg, GA, Dargie, HJ, Jardine, AG, Delles, C, and Dominiczak, AF (2007) Vascular function in patients with end-stage renal disease and/or coronary artery disease: A cardiac magnetic resonance imaging study. Kidney International, 71 . pp. 68-73. ISSN 0085-2538 (doi:10.1038/sj.ki.5002024)
2006
Al Benna, S., Hamilton, C.A., McClure, J.D., Rogers, P.N., Berg, G.A., Ford, I., Delles, C., and Dominiczak, A.F. (2006) Low-density lipoprotein cholesterol determines oxidative stress and endothelial dysfunction in saphenous veins from patients with coronary artery disease. Arteriosclerosis, Thrombosis and Vascular Biology, 26 . pp. 218-223. ISSN 1079-5642 (doi:10.1161/01.ATV.0000193626.22269.45)
Delles, C et al. (2006) Association between variants of the human GSTM gene family and hypertension. Hypertension, 48 (4). E27-E27. ISSN 0194-911X
Delles, C, and Dominiczak, AF (2006) Vascular failure or sick vessel syndrome: The cardiovascular continuum is a useful concept for clinical research. Journal of Hypertension, 24 (11). pp. 2147-2148. ISSN 0263-6352
Delles, C, Fleischmann, EH, Klingbeil, AU, Schaufele, TG, Schlaich, MP, and Schmieder, RE (2006) Impaired basal NO activity in patients with glomerular disease and the influence of oxidative stress. Kidney International, 70 (6). pp. 1177-1181. ISSN 0085-2538
Delles, C, Fleischmann, I, Sammer, U, Schlaich, M, Schmidt, BMW, and Schmieder, RE (2006) Rapid nongenomic effects of aldosterone on the renal vasculature in humans. Hypertension, 47 (4). pp. 650-655.
Delles, C, Handrock, R, Harazny, J, Michelson, G, Oehmer, S, Schmieder, RE, and Schwarz, T (2006) Valsartan and retinal endothelial function in elderly hypertensive patients. Blood Pressure, 15 (3). pp. 185-191.
Delles, C., Harazny, J., Michelson, G., Oehmer, S., Schmieder, R.E., and Warntges, S. (2006) Effect of NOS inhibition on retinal arterial and capillary circulation in early arterial hypertension. Retina: The Journal of Retinal and Vitreous Diseases, 26 (4). pp. 437-444.
McBride, MW, Graham, D, Delles, C, and Dominiczak, AF (2006) Functional genomics in hypertension. Current Opinion in Nephrology and Hypertension, 15 . pp. 145-151.
2005
Schneider, M.P., Delles, C., Schmidt, B.M.W., Oehmer, S., Schwarz, T.K., Schmieder, R.E., and John, S. (2005) Superoxide scavenging effects of N-acetylcysteine and vitamin C in subjects with essential hypertension. American Journal of Hypertension, 18 (8). pp. 1111-1117. ISSN 0895-7061 (doi:10.1016/j.amjhyper.2005.02.006)
John, S., Schneider, M.P., Delles, C., Jacobi, J., and Schmieder, R.E. (2005) Lipid-independent effects of statins on endothelial function and bioavailability of nitric oxide in hypercholesterolemic patients. American Heart Journal, 149 (3). 473.e1-473.e10. ISSN 0002-8703 (doi:10.1016/j.ahj.2004.06.02)
Brain, N.J.R., Charchar, F.J., Delles, C., Dominiczak, A.F., Graham, D., Hamilton, C.A., Lee, W.K., McGride, M.W., and Tomaszewski, M. (2005) Cardiovascular genomics and oxidative stress. Hypertension, 45 (4). pp. 636-642. ISSN 0194-911X
Delles, C, Fleischmann, EH, Klingbeil, AU, Schmieder, RE, and Veelken, R (2005) Additional antiproteinuric effect of ultrahigh dose candesartan: A double-blind, randomized, prospective study. Journal of the American Society of Nephrology, 16 (10). pp. 3038-3045.
2004
Delles, C., Klingbeil, A.U., Schneider, M.P., Handrock, R., Schaufele, T., and Schmieder, R.E. (2004) The role of nitric oxide in the regulation of glomerular haemodynamics in humans. Nephrology, Dialysis, Transplantation, 19 (6). pp. 1392-1397. ISSN 0931-0509 (doi:10.1093/ndt/gfh187)
Delles, C, Kunzendorf, U, Renders, L, Riess, R, Rosch, W, Rupprecht, HD, Schluter, C, Schott, GE, and Wittmann, M (2004) 'Very delayed' graft function in a patient after living related kidney transplantation: A case report. Transplantation Proceedings, 36 (5). pp. 1377-1379.
Delles, C, Schluter, C, Wittmann, M, Renders, L, Riess, R, Rosch, W, Schott, GE, Rupprecht, HD, and Kunzendorf, U (2004) "Very delayed" graft function in a patient after living related kidney transplantation: A case report. Transplantation Proceedings, 36 . pp. 1377-1379. (doi:10.1016/j.transproceed.2004.05.015)
Delles, C, and Schmieder, RE (2004) Effects of the angiotensin-1 receptor blocker valsartan compared with amlodipine on renal hemodynamics - Reply. American Journal of Hypertension, 17 (7). pp. 639-640.
Delles, C, and Schmieder, RE (2004) Is the afferent arteriole the main location of nitric oxide action and synthesis in humans? Reply. Nephrology, Dialysis, Transplantation, 19 (11). pp. 2925-2926. ISSN 0931-0509
Delles, C, and Schmieder, RE (2004) Renal endothelial effects of anti hypertensive therapy. Current Opinion in Nephrology and Hypertension, 13 (5). pp. 489-493.
Delles, C., Klingbeil, A.U., Kolloch, R.E., Krekler, M., Ludwig, M., Schmieder, R.E., Schneider, M.P., and Stumpe, K.O. (2004) Effect of irbesartan versus atenolol on left ventricular mass and voltage: results of the Cardio Vascular Irbesartan Project. Hypertension, 44 (1). pp. 61-66. ISSN 0194-911X (doi:10.1161/01.HYP.0000133249.28773.d7 )
Delles, C., Michelson, G., Harazny, J., Oehmer, S., Hilgers, K.F., and Schmieder, R.E. (2004) Impaired endothelial function of the retinal vasculature in hypertensive patients. Stroke, 35 (6). pp. 1289-1293. ISSN 0039-2499 (doi:10.1161/01.STR.0000126597.11534.3b)
Delles, C., Schneider, M., Oehmer, S., Fleischmann, I., Fleischmann, E.F., and Schmeider, R.E. (2004) Increased response of renal perfusion to the antioxidant vitamin C in type 2 diabetes. Nephrology, Dialysis, Transplantation, 19 (10). pp. 2513-2518. ISSN 0931-0509 (doi:10.1093/ndt/gfh405)
Fleischmann, E.H., John, S., Delles, C., Schneider, M.P., Schmidt, B.M.W., and Schmieder, R.E. (2004) The effect of statins on angiotensin II-induced hemodynamic changes in young, mildly hypercholesterolemic men. American Journal of Hypertension, 17 (12). pp. 1120-1126. ISSN 0895-7061 (doi:10.1016/j.amjhyper.2004.07.011)
2003
Delles, C., Klingbeil, A.U., Schneider, M.P., Handrock, R., Schmieder, R.E., and Weidinger, G. (2003) Direct comparison of the effects of valsartan and amlodipine on renal hemodynamics in human essential hypertension. American Journal of Hypertension, 16 (12). pp. 1030-1035. ISSN 0895-7061 (doi:10.1016/j.amjhyper.2003.07.017)
Schneider, M.P., Klingbeil, A.U., Delles, C., Schmidt, B.M.W., John, S., and Schmieder, R.E. (2003) Vitamin C augments the renal response to L-arginine in smokers. Nephrology, Dialysis, Transplantation, 18 (8). pp. 1512-1517. ISSN 0931-0509 (doi:10.1093/ndt/gfg195)
Delles, C., Schneider, M.P., Oehmer, S., Fleischmann, E.H., and Schmieder, R.E. (2003) L-arginine-induced vasodilation of the renal vasculature is not altered in hypertensive patients with type 2 diabetes. Diabetes Care, 26 (6). pp. 1836-1840. ISSN 0149-5992 (doi:10.2337/diacare.26.6.1836)
Schneider, M.P., Delles, C., Fleischmann, E., Schmidt, B.M.W., John, S., and Schmieder, R.E. (2003) Effect of elevated triglyceride levels on endothelium-dependent vasodilation in patients with hypercholesterolemia. American Journal of Cardiology, 91 (4). pp. 482-484. ISSN 0002-9149 (doi:10.1016/S0002-9149(02)03255-1)
Delles, C, Klingbeil, AU, Muller, HJ, Oehmer, S, Schmidt, BMW, and Schmieder, RE (2003) Functional relevance of aldosterone for the determination of left ventricular mass. American Journal of Cardiology, 91 (3). pp. 297-301.
Delles, C, and Schmieder, RE (2003) Endothelial function of the human renal vasculature. Deutsche Medizinische Wochenschrift, 128 (3). pp. 92-96.
Schmidt, B.M.W., Oehmer, S., Delles, C., Bratke, R., Schneider, M.P., Klingbeil, A., Fleischmann, E.H., and Schmieder, R.E. (2003) Rapid nongenomic effects of aldosterone on human forearm vasculature. Hypertension, 42 (2). pp. 156-160. ISSN 0194-911X (doi:10.1161/01.HYP.0000083298.23119.16)
Schneider, M.P., Hilgers, K.F., Huang, Y., Delles, C., John, S., Oehmer, S., and Schmieder, R.E. (2003) The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemia. Clinical Science, 105 (1). pp. 97-103. ISSN 0143-5221 (doi:10.1042/CS20030003)
2002
Delles, C., Schneider, M.P., John, S., Gekle, M., and Schmieder, R.E. (2002) Angiotensin converting enzyme inhibition and angiotensin II AT1-receptor blockade reduce the levels of asymmetrical N(G), N(G)-dimethylarginine in human essential hypertension. American Journal of Hypertension, 15 . pp. 590-593. ISSN 0895-7061
Schlaich, M.P., Klingbeil, A.U., Jacobi, J., Delles, C., Schneider, M.P., Schmidt, B.M., and Schmieder, R.E. (2002) Altered aldosterone response to salt intake and angiotensin II infusion in young normotensive men with parental history of arterial hypertension. Journal of Hypertension, 20 (1). pp. 117-24. ISSN 0263-6352
Bohner, C, Delles, C, Kunzendorf, U, Lang, W, Renders, L, Rupprecht, HD, Schott, GE, Wittmann, M, and Wutke, R (2002) Restoration of renal allograft function by endovascular stenting of an iliac artery dissection. Nephrology, Dialysis, Transplantation, 17 (6). pp. 1116-1118. ISSN 0931-0509
Delles, C, Fleischmann, I, Jacobi, J, John, S, and Schmieder, RE (2002) Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension. Kidney International, 61 (4). pp. 1462-1468. ISSN 0085-2538
Delles, C, Gekle, M, John, S, Schmieder, RE, and Schneider, MP (2002) Angiotensin converting enzyme inhibition and angiotensin II AT(1)-receptor blockade reduce the levels of asymmetrical N-G, N-G-dimethylarginine in human essential hypertension. American Journal of Hypertension, 15 (7). pp. 590-593.
Delles, C, Jacobi, J, John, S, Schlaich, MP, and Schmieder, RE (2002) Assessment of endothelial function of the renal vasculature in human subjects. American Journal of Hypertension, 15 (1). pp. 3-9.
Delles, C, Rupprecht, HD, Schobel, HP, and Weidner, S (2002) Renal-artery stenosis in a patient with Takayasu's arteritis. Nephrology, Dialysis, Transplantation, 17 (7). pp. 1339-1341. ISSN 0931-0509
2001
Zeltner, R., Delles, C., Schneider, M., Siffert, W., and Schmieder, R.E. (2001) G-protein beta(3) subunit gene (GNB3) 825T allele is associated with enhanced renal perfusion in early hypertension. Hypertension, 37 (3). pp. 882-886. ISSN 0194-911X (doi:10.1161/01.HYP.37.3.882)
Delles, C, Erdmann, J, Fleck, E, Hilgers, K, Jacobi, J, Regitz-Zagrosek, V, and Schmieder, RE (2001) Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans. Journal of the American College of Cardiology, 37 (1). pp. 175-182.
Delles, C, Erdmann, J, Fleck, E, Hilgers, KF, Jacobi, J, Regitz-Zagrosek, V, and Schmieder, RE (2001) Aldosterone synthase (CYP11B2)-344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension. Journal of the American College of Cardiology, 37 (3). pp. 878-884.
Delles, C, Erdmann, J, Fleck, E, Regitz-Zagrosek, V, Schmieder, RE, and Schneider, MP (2001) Functional gene testing of the Glu298Asp polymorphism of the endothelial nitric oxide synthase - Reply. Journal of Hypertension, 19 (7). pp. 1341-1342.
Delles, C, Hilgers, KF, Schmieder, RE, and Veelken, R (2001) Angiotensinogen gene core promoter variants and non-modulating hypertension. Hypertension, 38 (6). pp. 1250-1254.
Delles, C, Hilgers, KF, Schmieder, RE, and Veelken, R (2001) Outcome survey in unselected hypertensive patients with type 2 diabetes mellitus: effects of ACE inhibition. American Journal of Hypertension, 14 (7). pp. 672-678.
Delles, C, Kuchenbecker, C, Lederle, XAM, Leidig, MF, Schmieder, RE, and Weidinger, G (2001) Pharmacokinetics of valsartan in hypertensive patients on long-term haemodialysis. Clinical Drug Investigation, 21 (1). pp. 59-66.
Delles, C, and Schmieder, RE (2001) The kidney in congestive heart failure: Renal adverse event rate of treatment. Journal of Cardiovascular Pharmacology, 38 (1). pp. 99-107.
Delles, C., Jacobi, J., John, S., Schlaich, M.P., Schmieder, R.E., Schmitz, G., and Schneider, M. (2001) Rapid improvement of nitric oxide bioavailability after lipid-lowering therapy with cerivastatin within two weeks. Journal of the American College of Cardiology, 37 (5). pp. 1351-1358.
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Understanding variability in phenotype, and assessing the risk of serious cardiac events, in women and children with long QT syndrome.
Yorkhill Children's Foundation
2013 - 2015
- Cerebral and peripheral perfusion and reactivity in CADASIL: a longitudinal pilot study
Scottish Executive Health Department
2013 - 2015
- Cardiovascular consequences of preeclampsia in women from the Generation Scotland: Scottish Family Health Study.
Scottish Executive Health Department
2012 - 2014
- Inhibition of vascular Stat Signalling by Amp-Activated Protein Kinase (AMPK).
British Heart Foundation
2012 - 2015
- Travel Grant
Boehringer Ingelheim Fonds
2012 - 2012
- Serum phosphate as a cardiovascular risk factor: effects on vascular and endothelial function
British Heart Foundation
2012 - 2013
- PRIORITY: Intervention study for the prevention of diabetic nephropathy
European Commission
2012 - 2017
- EU-MASCARA - Biomarkers for Cardiovascular Disease
European Commission
2011 - 2015
- Reversal of pro-inflammatory interleukin-6 signalling by cyclic AMP-mediated induction of suppressor of cytokine signalling-3(SOCS-3)
Chest, Heart & Stroke, Scotland
2010 - 2011
- Euratrans
European Commission
2010 - 2014
- EPAC1 and ERK-dependent activation of C/EBP transcription factors: a new cyclic AMP-activated anti-inflammatory gene expression module in vascular endothelial cells
British Heart Foundation
2009 - 2012
- Induced pluripoptent cells: analysis of cell reprogramming of dermal fibroblasts derived from patients with disease vs age-matched healthy controls
British Heart Foundation
2009 - 2012
- Researcher Exchange from Faculdade de Medicina de Ribeirao Preto, Brazil
British Council - Manchester
2009 - 2009
- Collaborative strategy for a definitive genome scan in essential hypertension: high fidelity phenotyping and "hypercontrols"
British Heart Foundation
2008 - 2011
- Genomics and proteomics of hypertension and its vascular complications: the pathwayomic strategies.
British Heart Foundation
2008 - 2011
- Assessment of endothelial function in pregnancy: evaluation of a non-invasive method to analyse flow-mediated vasodilation
NHS Greater Glasgow & Clyde West Research Endowment Fund
2008 - 2010
- High throughput collaborative analysis of cardiovascular genes in 6000 hypertensives and 6000 controls
British Heart Foundation
2008 - 2009
- InGenious HyperCare - Integrating Genomics, Clinical Research and Care in Hypertension
European Commission
2006 - 2010
- 60th annual fall conference and scientific sessions of the Council for High Blood Pressure Research in association with the Council on the Kidney in Cardiovascular Disease
Royal Society
2006 - 2006
- Hydralazine in heart failure - a study of the mechanisms of action in human blood vessels
British Heart Foundation
2006 - 2009
