Dr Katie Hughes
- Research Associate (Parasitology)
telephone:
01413305616
email:
Katie.Hughes@glasgow.ac.uk
RB513 Level B5, Iii - Gbrc, University Place, Glasgow G12 8TA
Publications
2021
Simwela, N., Hughes, K. R., Rennie, M. T., Barrett, M. P. and Waters, A. P. (2021) Mammalian deubiquitinating enzyme inhibitors display. ACS Infectious Diseases, 7(2), pp. 333-346. (doi: 10.1021/acsinfecdis.0c00580) (PMID:33400499)
2020
Simwela, N., Hughes, K. R., Roberts, A. B., Rennie, M. T., Barrett, M. P. and Waters, A. P. (2020) Experimentally engineered mutations in a ubiquitin hydrolase, UBP-1, modulate in vivo susceptibility to artemisinin and chloroquine in Plasmodium berghei. Antimicrobial Agents and Chemotherapy, 64(7), (doi: 10.1128/AAC.02484-19) (PMID:32340987) (PMCID:PMC7318008)
Patil, H., Hughes, K. R., Lemgruber Soares, L. , Philip, N., Dickens, N. , Starnes, G. L. and Waters, A. P. (2020) Zygote morphogenesis but not the establishment of cell polarity in Plasmodium berghei is controlled by the small GTPase, RAB11A. PLoS Pathogens, 16(5), e1008091. (doi: 10.1371/journal.ppat.1008091) (PMID:32463831) (PMCID:PMC7255598)
2018
De Niz, M. et al. (2018) Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow. Science Advances, 4(5), eaat3775. (doi: 10.1126/sciadv.aat3775) (PMID:29806032) (PMCID:PMC5966192)
2017
Hughes, K. R. and Waters, A. P. (2017) Rapid inducible protein displacement in Plasmodium in vivo and in vitro using knocksideways technology. Wellcome Open Research, 2, 18. (doi: 10.12688/wellcomeopenres.11005.1) (PMID:28428983) (PMCID:PMC5395084)
2016
Srivastava, A., Philip, N., Hughes, K. R., Georgiou, K., MacRae, J. I., Barrett, M. P. , Creek, D. J., McConville, M. J. and Waters, A. P. (2016) Stage-specific changes in plasmodium metabolism required for differentiation and adaptation to different host and vector environments. PLoS Pathogens, 12(12), e1006094. (doi: 10.1371/journal.ppat.1006094) (PMID:28027318) (PMCID:PMC5189940)
2014
Sinha, A. et al. (2014) A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium. Nature, 507(7491), pp. 253-257. (doi: 10.1038/nature12970) (PMID:24572359) (PMCID:PMC4105895)
2010
Hughes, K.R., Philip, N., Lucas Starnes, G., Taylor, S. and Waters, A.P. (2010) From cradle to grave: RNA biology in malaria parasites. Wiley Interdisciplinary Reviews: RNA, 1(2), pp. 287-303. (doi: 10.1002/wrna.30)
Hughes, K. R., Biagini, G. A. and Craig, A. G. (2010) Continued cytoadherence of Plasmodium falciparum infected red blood cells after antimalarial treatment. Molecular and Biochemical Parasitology, 169(2), pp. 71-78. (doi: 10.1016/j.molbiopara.2009.09.007)
2008
Maier, A. G. et al. (2008) Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes. Cell, 134(1), pp. 48-61. (doi: 10.1016/j.cell.2008.04.051)
Chakravorty, S. J., Hughes, K. R. and Craig, A. G. (2008) Host response to cytoadherence in plasmodium falciparum. Biochemical Society Transactions, 36(Pt 2), pp. 221-228. (doi: 10.1042/BST0360221) (PMID:18363564)
2007
Hughes, K., Wand, M., Foulston, L., Young, R., Harley, K., Terry, S., Ersfeld, K. and Rudenko, G. (2007) A novel ISWI is involved in VSG expression site downregulation in African trypanosomes. EMBO Journal, 26(9), pp. 2400-2410. (doi: 10.1038/sj.emboj.7601678)
Articles
Simwela, N., Hughes, K. R., Rennie, M. T., Barrett, M. P. and Waters, A. P. (2021) Mammalian deubiquitinating enzyme inhibitors display. ACS Infectious Diseases, 7(2), pp. 333-346. (doi: 10.1021/acsinfecdis.0c00580) (PMID:33400499)
Simwela, N., Hughes, K. R., Roberts, A. B., Rennie, M. T., Barrett, M. P. and Waters, A. P. (2020) Experimentally engineered mutations in a ubiquitin hydrolase, UBP-1, modulate in vivo susceptibility to artemisinin and chloroquine in Plasmodium berghei. Antimicrobial Agents and Chemotherapy, 64(7), (doi: 10.1128/AAC.02484-19) (PMID:32340987) (PMCID:PMC7318008)
Patil, H., Hughes, K. R., Lemgruber Soares, L. , Philip, N., Dickens, N. , Starnes, G. L. and Waters, A. P. (2020) Zygote morphogenesis but not the establishment of cell polarity in Plasmodium berghei is controlled by the small GTPase, RAB11A. PLoS Pathogens, 16(5), e1008091. (doi: 10.1371/journal.ppat.1008091) (PMID:32463831) (PMCID:PMC7255598)
De Niz, M. et al. (2018) Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow. Science Advances, 4(5), eaat3775. (doi: 10.1126/sciadv.aat3775) (PMID:29806032) (PMCID:PMC5966192)
Hughes, K. R. and Waters, A. P. (2017) Rapid inducible protein displacement in Plasmodium in vivo and in vitro using knocksideways technology. Wellcome Open Research, 2, 18. (doi: 10.12688/wellcomeopenres.11005.1) (PMID:28428983) (PMCID:PMC5395084)
Srivastava, A., Philip, N., Hughes, K. R., Georgiou, K., MacRae, J. I., Barrett, M. P. , Creek, D. J., McConville, M. J. and Waters, A. P. (2016) Stage-specific changes in plasmodium metabolism required for differentiation and adaptation to different host and vector environments. PLoS Pathogens, 12(12), e1006094. (doi: 10.1371/journal.ppat.1006094) (PMID:28027318) (PMCID:PMC5189940)
Sinha, A. et al. (2014) A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium. Nature, 507(7491), pp. 253-257. (doi: 10.1038/nature12970) (PMID:24572359) (PMCID:PMC4105895)
Hughes, K.R., Philip, N., Lucas Starnes, G., Taylor, S. and Waters, A.P. (2010) From cradle to grave: RNA biology in malaria parasites. Wiley Interdisciplinary Reviews: RNA, 1(2), pp. 287-303. (doi: 10.1002/wrna.30)
Hughes, K. R., Biagini, G. A. and Craig, A. G. (2010) Continued cytoadherence of Plasmodium falciparum infected red blood cells after antimalarial treatment. Molecular and Biochemical Parasitology, 169(2), pp. 71-78. (doi: 10.1016/j.molbiopara.2009.09.007)
Maier, A. G. et al. (2008) Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes. Cell, 134(1), pp. 48-61. (doi: 10.1016/j.cell.2008.04.051)
Chakravorty, S. J., Hughes, K. R. and Craig, A. G. (2008) Host response to cytoadherence in plasmodium falciparum. Biochemical Society Transactions, 36(Pt 2), pp. 221-228. (doi: 10.1042/BST0360221) (PMID:18363564)
Hughes, K., Wand, M., Foulston, L., Young, R., Harley, K., Terry, S., Ersfeld, K. and Rudenko, G. (2007) A novel ISWI is involved in VSG expression site downregulation in African trypanosomes. EMBO Journal, 26(9), pp. 2400-2410. (doi: 10.1038/sj.emboj.7601678)