Dr Huabing Yin

  • Senior Lecturer (Biomedical Engineering)

telephone: +44(0)1413304109
email: Huabing.Yin@glasgow.ac.uk

Research interests

Biography

Dr Yin received her BSc (1992) and MSc (1995) in Chemistry in China. She obtained a PhD (2002) in Chemical Engineering at the University of Wales, Swansea, focusing on nanofiltration membrane development and applications. From 2003 to 2005, she worked as a postdoctoral researcher at the University of Southampton, developing an optical biosensor for gene analysis.

Shortly after joining the University of Glasgow as a postdoctoral researcher, developing microfluidics for high throughput cellular analysis, she was awarded a personal research fellowship from the Royal Society of Edinburgh (2006-2009). After this she was appointed to a lectureship in 2010 and promoted to a senior lecturer in 2011. 

Research Interests

My research focuses on developing technologies to understand how a cell, a fundamental unit of life, interacts with its surroundings at the micro-scale; and exploiting this knowledge to benefit health care and the environment. Much of my research converges on micro-/nanofabrication, surface functionalisation, microfluidics and advanced microscopic and spectroscopy technologies. Current activities can be divided into the following themes:

Single-cell analysis: Even in a genetically identical group of cells, individual difference exists. This heterogeneity can dramatically influence cell fate, but is masked when cells are studied using traditional research methods that use average responses from a cell population. We have developed a number of techniques and devices for both mammalian cells and microorganisms, to analyse single cells in a population. These approaches can then be employed to address many topics including drug screening, cancer metastasis, bacterial resistance, and single cell sorting based on Raman signals (i.e. Raman activated cell sorting). The rich information obtained from individuals has led to unprecedented discoveries that significantly advance the knowledge in the field.

Portable devices for diagnosis: Conventional spectroscopic instruments are too bulky to be used in the field. Using advanced nanofabrication technology; we have developed a miniaturised microspectrometer- microfluidic system, capable of performing multiplexing, spectroscopic bioassays in a portable format. This system is of great use in testing samples in resource-limited environments, such as in developing countries or remote industrial plants.

Engineering cellular microenvironments: The interaction between a cell and its environment is influenced by a broad spectrum of physical, chemical and biological cues. Taking a reductionist approach, we are developing microstructured, functional 2D surfaces and 3D biomaterial that resemble key features in the naturally occurring microenvironments, to study cell behaviour in both physiology and pathologic conditions. In collaboration with life scientists and pharmaceutical industries, we are implementing these devices for drug screening, tissue regeneration and cancer research.

Cell mechanics: Physical forces play essential roles in cell functioning, but are difficult to measure at the single cell level. Using Atomic Force Microscopy AFM), we have developed various methods to quantify cell mechanical properties (e.g. stiffness, viscoelasticity) and the interaction forces between cell and matrix. These capabilities, together with our activities in the other themes, provide us a powerful toolbox to develop useful solutions for challenging problems in tissue engineering and cancer research.

Expertise

Microfluidics, optical biosensor, single cell technology, surface patterning, interfaces and biomaterials characterisation, Atomic Force Microscopy on biological samples.

 

Selected publications

Grants

  • 2016 – 2017 “Stable Isotope Probing with Resonance Raman Cell Sorting to profile influence of ocean acidification on microbial carbon fixation”. NERC(NE/P003826/1).
  • 2016 – 2018 “Engineering Microbial Cell Factories for Industrial Carotenoids Biosynthesis”. IBioIC.
  • 2016 – 2020 “EPSRC Centre for Multiscale Soft Tissue Mechanics - with application to heart & cancer”. EPSRC(EP/N014642/1).
  • 2014 – 2019 “Development of a continuous microfluidic – Raman sorting platform”. NISSAN-CHEM Ltd.
  • 2010 – 2016 “Engineering a semi-biotic immune system”. EPSRC(EP/H04986X/1).
  • 2012 – 2014 “Shell inspiration: turning nature’s secrets into engineering solutions”. EPSRC(EP/J009121/1).
  • 2013 – 2014 “Microfluidic fibre extrusion for bone replacement”. BBSRC (BB/J021083/1).
  • 2012 – 2013 "Generation of a large family of genetic logic gates for applications in biosensing and information processing". BBSRC (BB/J020133/1).
  • 2010 – 2014 “Delivery of cell phenotype authentication”. EPSRC & LGC Ltd Case award.
  • 2010 – 2012 “Substrate control of cell shape and effect on gene expression”, in collaboration with the University of Manchester. The Leverhulme Trust.
  • 2010 – 2012 “Collagen characterization”. KTP and Devro plc.
  • 2010 – 2011 “Microfluidic technology for controlled synthesis of nanodelivery systems”. Royal Academy of Engineering.
  • 2006 – 2009 “Click-Chemistries for 2D and 3D Programmable Surfaces”. Royal Society of Edinburgh Personal Research Fellowship.

Supervision

Current research staff

  • Xiaofei Yuan
  • Yanqing Song

 

Current PhD students

  • Louise Mason
  • Yinkai Lyu
  • Giulia Spennati
  • Laura Charlton
  • Jason Bolderson
  • Rémi Caudoux
  • Yahua Chim

Teaching

  • Electronic Devices II (ENG2026) - Course coordinator
  • Microscopy and Optics III (ENG3038) - Course coordinator
  • Scaffolds and Tissues M (ENG5282)

All publications

List by: Type | Date

Jump to: 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2002 | 2001
Number of items: 57.

2017

Hernandez-Fernaud, J. R. et al. (2017) Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nature Communications, 8, 14206. (doi:10.1038/ncomms14206) (PMID:28198360)

Wei, D., Sun, J., Bolderson, J., Zhong, M., Dalby, M. J., Cusack, M., Yin, H., Fan, H., and Zhang, X. (2017) Continuous fabrication and assembly of spatial cell-laden fibers for a tissue-like construct via a photolithographic-based microfluidic chip. ACS Applied Materials and Interfaces, (doi:10.1021/acsami.7b00078) (PMID:28157291) (Early Online Publication)

Song, Y. et al. (2017) Single-cell genomics based on Raman sorting reveals novel carotenoid-containing bacteria in the Red Sea. Microbial Biotechnology, 10(1), pp. 125-137. (doi:10.1111/1751-7915.12420) (PMID:27748032)

2016

Song, Y., Yin, H., and Huang, W. E. (2016) Raman activated cell sorting. Current Opinion in Chemical Biology, 33, pp. 1-8. (doi:10.1016/j.cbpa.2016.04.002) (PMID:27100046)

McIlvanna, D., Huang, W. E., Davison, P., Glidle, A., Cooper, J., and Yin, H. (2016) Continuous cell sorting in a flow based on single cell resonance Raman spectra. Lab on a Chip, 16(8), pp. 1420-1429. (doi:10.1039/C6LC00251J) (PMID:26974400)

Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26(6), pp. 755-765. (doi:10.1016/j.cub.2016.01.045) (PMID:26948875)

Cachat, E., Liu, W., Martin, K. C., Yuan, X., Yin, H., Hohenstein, P., and Davies, J. A. (2016) 2- and 3-dimensional synthetic large-scale de novo patterning by mammalian cells through phase separation. Scientific Reports, 6, 20664. (doi:10.1038/srep20664) (PMID:26857385) (PMCID:PMC4746622)

Li, B., Qiu, Y., Shi, H., and Yin, H. (2016) The importance of lag time extension in determining bacterial resistance to antibiotics. Analyst, 141(10), pp. 3059-3067. (doi:10.1039/C5AN02649K) (PMID:27077143)

2015

Yuan, X., Zhou, M., Gough, J., Glidle, A., and Yin, H. (2015) A novel culture system for modulating single cell geometry in 3D. Acta Biomaterialia, 24, pp. 228-240. (doi:10.1016/j.actbio.2015.06.008) (PMID:26086694)

Cameron, J. M., Gabrielsen, M., Chim, Y. H., Munro, J., McGhee, E. J., Sumpton, D., Eaton, P., Anderson, K. I., Yin, H., and Olson, M. F. (2015) Polarized cell motility induces hydrogen peroxide to inhibit cofilin via cysteine oxidation. Current Biology, 25(11), pp. 1520-1525. (doi:10.1016/j.cub.2015.04.020)

Zhou, M., Yuan, X., Yin, H., and Gough, J. E. (2015) Restoration of chondrocytic phenotype on a two-dimensional micropatterned surface. Biointerphases, 10, 011003. (doi:10.1116/1.4913565)

Zhang, P., Ren, L., Zhang, X., Shan, Y., Wang, Y., Ji, Y., Yin, H., Huang, W. E., Xu, J., and Ma, B. (2015) Raman-activated cell sorting based on dielectrophoretic single-cell trap and release. Analytical Chemistry, 87(4), pp. 2282-2289. (doi:10.1021/ac503974e) (PMID:25607599)

Wang, J., Wu, Z., Hu, K., Chen, X., and Yin, H. (2015) High conductivity graphene-like MoS2/polyaniline nanocomposites and its application in supercapacitor. Journal of Alloys and Compounds, 619, pp. 38-43. (doi:10.1016/j.jallcom.2014.09.008)

Hu, Z., Glidle, A., Ironside, C., Cooper, J. M., and Yin, H. (2015) An integrated microspectrometer for localised multiplexing measurements. Lab on a Chip, 15(1), pp. 283-289. (doi:10.1039/C4LC00952E)

Song, Y., Li, B., Qiu, Y., and Yin, H. (2015) Single bacteria studies using microfluidics. In: Hydrocarbon and Lipid Microbiology Protocols. Series: Springer Protocols Handbooks. Springer. (doi:10.1007/8623_2015_70)

Wang, J., Guo, C., Yu, Y., Yin, H., Liu, X., and Jiang, Y. (2015) Self-doped 3-hexylthiophene-b-sodium styrene sulfonate block copolymer: synthesis and its organization with CdSe quantum dots. RSC Advances, 5(23), pp. 17905-17914. (doi:10.1039/c4ra15195j)

2014

Li, B., Qiu, Y., Glidle, A., Cooper, J., Shi, H., and Yin, H. (2014) Single cell growth rate and morphological dynamics revealing an "opportunistic" persistence. Analyst, 139(13), pp. 3305-3313. (doi:10.1039/C4AN00170B)

Li, B., Qiu, Y., Glidle, A., McIlvenna, D., Luo, Q., Cooper, J., Shi, H.-C., and Yin, H. (2014) Gradient microfluidics enables rapid bacterial growth inhibition testing. Analytical Chemistry, 86(6), pp. 3131-3137. (doi:10.1021/ac5001306)

Wang, J., Wu, Z., Yin, H., Li, W., and Jiang, Y. (2014) Poly(3,4-ethylenedioxythiophene)/MoS2nanocomposites with enhanced electrochemical capacitance performance. RSC Advances, 4(100), pp. 56926-56932. (doi:10.1039/C4RA12683A)

Yuan, X., Chim, Y., and Yin, H. (2014) Linking cell shape, elasticity and fate: in vitro re-differentiation of chondrocytes. In: Optical Elastography and Tissue Biomechanics, San Francisco, CA, USA, 1-2 Feb 2014, 89460M. (doi:10.1117/12.2039859)

Zhao, C., Lin, Z., Yin, H., Ma, Y., Xu, F., and Yang, W. (2014) PEG molecular net-cloth grafted on polymeric substrates and its bio-merits. Scientific Reports, 4, 4982. (doi:10.1038/srep04982) (PMID:24845078) (PMCID:PMC4028697)

2013

Li, C., Glidle, A., Yuan, X., Hu, Z., Pulleine, E., Cooper, J., Yang, W., and Yin, H. (2013) Creating “living” polymer surfaces to pattern biomolecules and cells on common plastics. Biomacromolecules, 14(5), pp. 1278-1286. (doi:10.1021/bm4000597) (PMID:23495918)

Milton, J. A., Patole, S., Yin, H., Xiao, Q., Brown, T., and Melvin, T. (2013) Efficient self-assembly of DNA-functionalized fluorophores and gold nanoparticles with DNA functionalized silicon surfaces: the effect of oligomer spacers. Nucleic Acids Research, 41(7), e80. (doi:10.1093/nar/gkt031) (PMID:23361467) (PMCID:PMC3627567)

2012

Qiu, N. et al. (2012) Calcium carbonate microspheres as carriers for the anticancer drug camptothecin. Materials Science and Engineering C: Biomimetic and Supramolecular Systems, 32(8), pp. 2634-2640. (doi:10.1016/j.msec.2012.08.026)

Hu, Z., Glidle, A., Ironside, C. N., Sorel, M., Strain, M. J., Cooper, J., and Yin, H. (2012) Integrated microspectrometer for fluorescence based analysis in a microfluidic format. Lab on a Chip, 12(16), pp. 2850-2857. (doi:10.1039/C2LC40169J)

Zarowna-Dabrowska, A. et al. (2012) Generation of primary hepatocyte microarrays by piezoelectric printing. Colloids and Surfaces B: Biointerfaces, 89, pp. 126-132. (doi:10.1016/j.colsurfb.2011.09.016)

Cuestas-Ayllon, C., Xiao, Q., Glidle, A., Riehle, M.O., Cooper, J. M., de la Fuente, J. M., and Yin, H. B. (2012) A robust lithographic method for multiplex surface pattering. Current Analytical Chemistry, 9(1), pp. 29-36. (doi:10.2174/1573411011309010029)

Yin, H., and Marshall, D. (2012) Microfluidics for single cell analysis. Current Opinion in Biotechnology, 23(1), pp. 110-119. (doi:10.1016/j.copbio.2011.11.002)

2011

Kirchhof, K., Andar, A., Yin, H.B., Gadegaard, N., Riehle, M.O., and Groth, T. (2011) Polyelectrolyte multilayers generated in a microfluidic device with pH gradients direct adhesion and movement of cells. Lab on a Chip, 11(19), pp. 3326-3335. (doi:10.1039/C1LC20408D)

Hu, Z., Glidle, A., Ironside, C.N., Sorel, M., Strain, M.J., and Yin, H. (2011) On-chip micro-spectrometer for fluorescence bio-sensing. In: CLEO Europe 2011, Munich, Germany, 22-26 May 2011, (doi:10.1109/CLEOE.2011.5943698)

Zarowna-Dabrowska, A. et al. (2011) Miniaturized optoelectronic tweezers controlled by GaN micro-pixel light emitting diode arrays. Optics Express, 19(3), pp. 2720-2728. (doi:10.1364/OE.19.002720)

2010

Qiu, N., Cai, L.-l., Xie, D., Wang, G., Wu, W., Zhang, Y., Song, H., Yin, H., and Chen, L. (2010) Synthesis, structural andin vitrostudies of well-dispersed monomethoxy-poly(ethylene glycol)–honokiol conjugate micelles. Biomedical Materials, 5(6), 065006. (doi:10.1088/1748-6041/5/6/065006) (PMID:20966535)

Anderson, K.J., Cooper, J.M., Haswell, S.J., Marshall, D., Yin, H., and Zhang, X.L. (2010) Microfluidic-based measurements of cytochrome P450 enzyme activity of primary mammalian hepatocytee. Analyst, 135(6), pp. 1282-1287. (doi:10.1039/c0an00031k)

Ji, B., Cusack, M., Freer, A., Dobson, P.S., Gadegaard, N., and Yin, H. (2010) Control of crystal polymorph in microfluidics using molluscan 28 kDa Ca2+-binding protein. Integrative Biology, 2, pp. 528-535. (doi:10.1039/c0ib00007h)

McPhee, G., Dalby, M.J., Riehle, M.O., and Yin, H. (2010) Can common adhesion molecules and microtopography affect cellular elasticity? A combined atomic force microscopy and optical study. Medical and Biological Engineering and Computing, 48(10), (doi:10.1007/s11517-010-0657-3)

Zarowna-Dabrowska, A. et al. (2010) Micromanipulation of beads and CHO cells using micro light emitting diode arrays to control a miniaturised optoelectronic tweezers device. In: IOP Photon10, Southampton, UK, 23-26 Aug 2010,

Zarowna-Dabrowska, A. et al. (2010) Miniaturised optoelectronic tweezers controlled by GaN micro light emitting diode arrays. In: 23rd Annual Meeting of the IEEE Photonics Society, Denver, CO, 7-11 Nov 2010,

2009

Ritchie, C., Cooper, G.J.T., Song, Y.F., Streb, C., Yin, H.B., Parenty, A.D.C., MacLaren, D.A., and Cronin, L. (2009) Spontaneous assembly and real-time growth of micrometre-scale tubular structures from polyoxometalate-based inorganic solids. Nature Chemistry, 1(1), pp. 47-52. (doi:10.1038/nchem.113)

Yin, H., Bozhi, J., Dobson, P.S., Mosbahi, K., Glidle, A., Gadegaard, N., Freer, A., Cooper, J.M., and Cusack, M. (2009) Screening of biomineralization using microfluidics. Analytical Chemistry, 81(1), pp. 473-478. (doi:10.1021/ac801980b)

Yin, H., McPhee, G., and Dobson, P. (2009) AFM and development of (bio) fouling-resistant membranes. In: Bowen, W.R. and Hilal, N. (eds.) Atomic Force Microscopy in Process Engineering: Introduction to AFM for Improved Processes and Products. Butterworth-Heinemann: Oxford, UK. ISBN 9781856175173

Yin, H., McPhee, G., and Dobson, P. (2009) Micro/nanoengineering and AFM for cellular sensing. In: Bowen, W.R. and Hilal, N. (eds.) Atomic Force Microscopy in Process Engineering: Introduction to AFM for Improved Processes and Products. Butterworth-Heinemann: Oxford, UK. ISBN 9781856175173

2008

Cusack, M., Dauphin, Y., Cuif, J.P., Salomé, M., Freer, A., and Yin, H. (2008) Micro-XANES mapping of sulphur and its association with magnesium and phosphorus in the shell of the brachiopod, Terebratulina retusa. Chemical Geology, 253(3-4), pp. 172-179. (doi:10.1016/j.chemgeo.2008.05.007)

Zhang, X.L., Yin, H.B., Cooper, J.M., and Haswell, S.J. (2008) Characterization of cellular chemical dynamics using combined microfluidic and Raman techniques. Analytical and Bioanalytical Chemistry, 390(3), pp. 833-840. (doi:10.1007/s00216-007-1564-9)

Yin, H., Pattrick, N., Zhang, X.L., Klauke, N., Cordingley, H.C., Haswell, S.J., and Cooper, J.M. (2008) Quantitative comparison between microfluidic and microtiter plate formats for cell-based assays. Analytical Chemistry, 80(1), pp. 179-185. (doi:10.1021/ac701958z)

Mushfique, H., Leach, J., Yin, H., Di Leonardo, R., Padgett, M.J., and Cooper, J.M. (2008) 3D mapping of microfluidic flow in laboratory-on-a-chip structures using optical tweezers. Analytical Chemistry, 80(11), pp. 4237-4240. (doi:10.1021/ac8002006)

2007

Yin, H., Zhang, X.L., Pattrick, N., Klauke, N., Cordingley, H.C., Haswell, S.J., and Cooper, J.M. (2007) Influence of hydrodynamic conditions on quantitative cellular assays in microfluidic systems. Analytical Chemistry, 79(18), pp. 7139-7144. (doi:10.1021/ac071146k)

2006

Melvin, T. et al. (2006) DNA, Nanoparticles and Photons - New Approaches for Clinical Diagnostics. In: 2006 International Symposium on Biophotonics, Nanophotonics and Metamaterials, Hangzhou, China, 16-18 Oct 2006, pp. 20-21. ISBN 9780780397743 (doi:10.1109/METAMAT.2006.334986)

Zhang, X.L., Yin, H., Cooper, J.M., and Haswell, S.J. (2006) A microfluidic-based system for analysis of single cells based on Ca2+ flux. Electrophoresis, 27(24), pp. 5093-5100. (doi:10.1002/elps.200600390)

2005

Dyadyusha, L., Yin, H., Jaiswal, S., Brown, T., Baumberg, J.J., Booy, F.P., and Melvin, T. (2005) Quenching of CdSe quantum dot emission, a new approach for biosensing. Chemical Communications(25), pp. 3201-3203. (doi:10.1039/B500664c) (PMID:15968371)

2004

Yin, H. B., Brown, T., Greef, R., Mailis, S., Eason, R., Wilkinson, J. S., and Melvin, T. (2004) Photopatterning of DNA oligonucleotides on silicon surfaces with micron-scale dimensions. In: Biophotonics New Frontier: From Genome to Proteome, Strasbourg, France, 26 Apr 2004, ISBN 9780819453846 (doi:10.1117/12.545736)

Yin, H.B., Brown, T., Greef, R., Wilkinson, J.S., and Melvin, T. (2004) Chemical modification and micropatterning of Si(1 0 0) with oligonucleotides. Microelectronic Engineering, 73-74, pp. 830-836. (doi:10.1016/j.mee.2004.03.060)

Doneva, T.A., Yin, H.B., Stephens, P., Bowen, W.R., and Thomas, D.W. (2004) Development and AFM study of porous scaffolds for wound healing applications. Spectroscopy, 18(4), pp. 587-596. (doi:10.1155/2004/251698)

Yin, H.B., Brown, T., Wilkinson, J.S., Eason, R.W., and Melvin, T. (2004) Submicron patterning of DNA oligonucleotides on silicon. Nucleic Acids Research, 32(14), e118. (doi:10.1093/nar/gnh113) (PMID:15314186) (PMCID:PMC514397)

2002

Bowen, W. R., Doneva, T. A., and Yin, H.B. (2002) Atomic force microscopy studies of membrane—solute interactions (fouling). Desalination, 146(1-3), pp. 97-102. (doi:10.1016/S0011-9164(02)00496-4)

Bowen, W. R., Doneva, T. A., and Yin, H. (2002) The effect of sulfonated poly(ether ether ketone) additives on membrane formation and performance. Desalination, 145(1-3), pp. 39-45. (doi:10.1016/S0011-9164(02)00364-8)

Bowen, W. R., Doneva, T. A., and Yin, H.-B. (2002) Separation of humic acid from a model surface water with PSU/SPEEK blend UF/NF membranes. Journal of Membrane Science, 206(1-2), pp. 417-429. (doi:10.1016/S0376-7388(01)00786-4)

2001

Bowen, W. R., Doneva, T. A., and Yin, H.B. (2001) Polysulfone — sulfonated poly(ether ether) ketone blend membranes: systematic synthesis and characterisation. Journal of Membrane Science, 181(2), pp. 253-263. (doi:10.1016/S0376-7388(00)00541-X)

This list was generated on Wed Mar 29 23:55:54 2017 BST.
Number of items: 57.

Articles

Hernandez-Fernaud, J. R. et al. (2017) Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nature Communications, 8, 14206. (doi:10.1038/ncomms14206) (PMID:28198360)

Wei, D., Sun, J., Bolderson, J., Zhong, M., Dalby, M. J., Cusack, M., Yin, H., Fan, H., and Zhang, X. (2017) Continuous fabrication and assembly of spatial cell-laden fibers for a tissue-like construct via a photolithographic-based microfluidic chip. ACS Applied Materials and Interfaces, (doi:10.1021/acsami.7b00078) (PMID:28157291) (Early Online Publication)

Song, Y. et al. (2017) Single-cell genomics based on Raman sorting reveals novel carotenoid-containing bacteria in the Red Sea. Microbial Biotechnology, 10(1), pp. 125-137. (doi:10.1111/1751-7915.12420) (PMID:27748032)

Song, Y., Yin, H., and Huang, W. E. (2016) Raman activated cell sorting. Current Opinion in Chemical Biology, 33, pp. 1-8. (doi:10.1016/j.cbpa.2016.04.002) (PMID:27100046)

McIlvanna, D., Huang, W. E., Davison, P., Glidle, A., Cooper, J., and Yin, H. (2016) Continuous cell sorting in a flow based on single cell resonance Raman spectra. Lab on a Chip, 16(8), pp. 1420-1429. (doi:10.1039/C6LC00251J) (PMID:26974400)

Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26(6), pp. 755-765. (doi:10.1016/j.cub.2016.01.045) (PMID:26948875)

Cachat, E., Liu, W., Martin, K. C., Yuan, X., Yin, H., Hohenstein, P., and Davies, J. A. (2016) 2- and 3-dimensional synthetic large-scale de novo patterning by mammalian cells through phase separation. Scientific Reports, 6, 20664. (doi:10.1038/srep20664) (PMID:26857385) (PMCID:PMC4746622)

Li, B., Qiu, Y., Shi, H., and Yin, H. (2016) The importance of lag time extension in determining bacterial resistance to antibiotics. Analyst, 141(10), pp. 3059-3067. (doi:10.1039/C5AN02649K) (PMID:27077143)

Yuan, X., Zhou, M., Gough, J., Glidle, A., and Yin, H. (2015) A novel culture system for modulating single cell geometry in 3D. Acta Biomaterialia, 24, pp. 228-240. (doi:10.1016/j.actbio.2015.06.008) (PMID:26086694)

Cameron, J. M., Gabrielsen, M., Chim, Y. H., Munro, J., McGhee, E. J., Sumpton, D., Eaton, P., Anderson, K. I., Yin, H., and Olson, M. F. (2015) Polarized cell motility induces hydrogen peroxide to inhibit cofilin via cysteine oxidation. Current Biology, 25(11), pp. 1520-1525. (doi:10.1016/j.cub.2015.04.020)

Zhou, M., Yuan, X., Yin, H., and Gough, J. E. (2015) Restoration of chondrocytic phenotype on a two-dimensional micropatterned surface. Biointerphases, 10, 011003. (doi:10.1116/1.4913565)

Zhang, P., Ren, L., Zhang, X., Shan, Y., Wang, Y., Ji, Y., Yin, H., Huang, W. E., Xu, J., and Ma, B. (2015) Raman-activated cell sorting based on dielectrophoretic single-cell trap and release. Analytical Chemistry, 87(4), pp. 2282-2289. (doi:10.1021/ac503974e) (PMID:25607599)

Wang, J., Wu, Z., Hu, K., Chen, X., and Yin, H. (2015) High conductivity graphene-like MoS2/polyaniline nanocomposites and its application in supercapacitor. Journal of Alloys and Compounds, 619, pp. 38-43. (doi:10.1016/j.jallcom.2014.09.008)

Hu, Z., Glidle, A., Ironside, C., Cooper, J. M., and Yin, H. (2015) An integrated microspectrometer for localised multiplexing measurements. Lab on a Chip, 15(1), pp. 283-289. (doi:10.1039/C4LC00952E)

Wang, J., Guo, C., Yu, Y., Yin, H., Liu, X., and Jiang, Y. (2015) Self-doped 3-hexylthiophene-b-sodium styrene sulfonate block copolymer: synthesis and its organization with CdSe quantum dots. RSC Advances, 5(23), pp. 17905-17914. (doi:10.1039/c4ra15195j)

Li, B., Qiu, Y., Glidle, A., Cooper, J., Shi, H., and Yin, H. (2014) Single cell growth rate and morphological dynamics revealing an "opportunistic" persistence. Analyst, 139(13), pp. 3305-3313. (doi:10.1039/C4AN00170B)

Li, B., Qiu, Y., Glidle, A., McIlvenna, D., Luo, Q., Cooper, J., Shi, H.-C., and Yin, H. (2014) Gradient microfluidics enables rapid bacterial growth inhibition testing. Analytical Chemistry, 86(6), pp. 3131-3137. (doi:10.1021/ac5001306)

Wang, J., Wu, Z., Yin, H., Li, W., and Jiang, Y. (2014) Poly(3,4-ethylenedioxythiophene)/MoS2nanocomposites with enhanced electrochemical capacitance performance. RSC Advances, 4(100), pp. 56926-56932. (doi:10.1039/C4RA12683A)

Zhao, C., Lin, Z., Yin, H., Ma, Y., Xu, F., and Yang, W. (2014) PEG molecular net-cloth grafted on polymeric substrates and its bio-merits. Scientific Reports, 4, 4982. (doi:10.1038/srep04982) (PMID:24845078) (PMCID:PMC4028697)

Li, C., Glidle, A., Yuan, X., Hu, Z., Pulleine, E., Cooper, J., Yang, W., and Yin, H. (2013) Creating “living” polymer surfaces to pattern biomolecules and cells on common plastics. Biomacromolecules, 14(5), pp. 1278-1286. (doi:10.1021/bm4000597) (PMID:23495918)

Milton, J. A., Patole, S., Yin, H., Xiao, Q., Brown, T., and Melvin, T. (2013) Efficient self-assembly of DNA-functionalized fluorophores and gold nanoparticles with DNA functionalized silicon surfaces: the effect of oligomer spacers. Nucleic Acids Research, 41(7), e80. (doi:10.1093/nar/gkt031) (PMID:23361467) (PMCID:PMC3627567)

Qiu, N. et al. (2012) Calcium carbonate microspheres as carriers for the anticancer drug camptothecin. Materials Science and Engineering C: Biomimetic and Supramolecular Systems, 32(8), pp. 2634-2640. (doi:10.1016/j.msec.2012.08.026)

Hu, Z., Glidle, A., Ironside, C. N., Sorel, M., Strain, M. J., Cooper, J., and Yin, H. (2012) Integrated microspectrometer for fluorescence based analysis in a microfluidic format. Lab on a Chip, 12(16), pp. 2850-2857. (doi:10.1039/C2LC40169J)

Zarowna-Dabrowska, A. et al. (2012) Generation of primary hepatocyte microarrays by piezoelectric printing. Colloids and Surfaces B: Biointerfaces, 89, pp. 126-132. (doi:10.1016/j.colsurfb.2011.09.016)

Cuestas-Ayllon, C., Xiao, Q., Glidle, A., Riehle, M.O., Cooper, J. M., de la Fuente, J. M., and Yin, H. B. (2012) A robust lithographic method for multiplex surface pattering. Current Analytical Chemistry, 9(1), pp. 29-36. (doi:10.2174/1573411011309010029)

Yin, H., and Marshall, D. (2012) Microfluidics for single cell analysis. Current Opinion in Biotechnology, 23(1), pp. 110-119. (doi:10.1016/j.copbio.2011.11.002)

Kirchhof, K., Andar, A., Yin, H.B., Gadegaard, N., Riehle, M.O., and Groth, T. (2011) Polyelectrolyte multilayers generated in a microfluidic device with pH gradients direct adhesion and movement of cells. Lab on a Chip, 11(19), pp. 3326-3335. (doi:10.1039/C1LC20408D)

Zarowna-Dabrowska, A. et al. (2011) Miniaturized optoelectronic tweezers controlled by GaN micro-pixel light emitting diode arrays. Optics Express, 19(3), pp. 2720-2728. (doi:10.1364/OE.19.002720)

Qiu, N., Cai, L.-l., Xie, D., Wang, G., Wu, W., Zhang, Y., Song, H., Yin, H., and Chen, L. (2010) Synthesis, structural andin vitrostudies of well-dispersed monomethoxy-poly(ethylene glycol)–honokiol conjugate micelles. Biomedical Materials, 5(6), 065006. (doi:10.1088/1748-6041/5/6/065006) (PMID:20966535)

Anderson, K.J., Cooper, J.M., Haswell, S.J., Marshall, D., Yin, H., and Zhang, X.L. (2010) Microfluidic-based measurements of cytochrome P450 enzyme activity of primary mammalian hepatocytee. Analyst, 135(6), pp. 1282-1287. (doi:10.1039/c0an00031k)

Ji, B., Cusack, M., Freer, A., Dobson, P.S., Gadegaard, N., and Yin, H. (2010) Control of crystal polymorph in microfluidics using molluscan 28 kDa Ca2+-binding protein. Integrative Biology, 2, pp. 528-535. (doi:10.1039/c0ib00007h)

McPhee, G., Dalby, M.J., Riehle, M.O., and Yin, H. (2010) Can common adhesion molecules and microtopography affect cellular elasticity? A combined atomic force microscopy and optical study. Medical and Biological Engineering and Computing, 48(10), (doi:10.1007/s11517-010-0657-3)

Ritchie, C., Cooper, G.J.T., Song, Y.F., Streb, C., Yin, H.B., Parenty, A.D.C., MacLaren, D.A., and Cronin, L. (2009) Spontaneous assembly and real-time growth of micrometre-scale tubular structures from polyoxometalate-based inorganic solids. Nature Chemistry, 1(1), pp. 47-52. (doi:10.1038/nchem.113)

Yin, H., Bozhi, J., Dobson, P.S., Mosbahi, K., Glidle, A., Gadegaard, N., Freer, A., Cooper, J.M., and Cusack, M. (2009) Screening of biomineralization using microfluidics. Analytical Chemistry, 81(1), pp. 473-478. (doi:10.1021/ac801980b)

Cusack, M., Dauphin, Y., Cuif, J.P., Salomé, M., Freer, A., and Yin, H. (2008) Micro-XANES mapping of sulphur and its association with magnesium and phosphorus in the shell of the brachiopod, Terebratulina retusa. Chemical Geology, 253(3-4), pp. 172-179. (doi:10.1016/j.chemgeo.2008.05.007)

Zhang, X.L., Yin, H.B., Cooper, J.M., and Haswell, S.J. (2008) Characterization of cellular chemical dynamics using combined microfluidic and Raman techniques. Analytical and Bioanalytical Chemistry, 390(3), pp. 833-840. (doi:10.1007/s00216-007-1564-9)

Yin, H., Pattrick, N., Zhang, X.L., Klauke, N., Cordingley, H.C., Haswell, S.J., and Cooper, J.M. (2008) Quantitative comparison between microfluidic and microtiter plate formats for cell-based assays. Analytical Chemistry, 80(1), pp. 179-185. (doi:10.1021/ac701958z)

Mushfique, H., Leach, J., Yin, H., Di Leonardo, R., Padgett, M.J., and Cooper, J.M. (2008) 3D mapping of microfluidic flow in laboratory-on-a-chip structures using optical tweezers. Analytical Chemistry, 80(11), pp. 4237-4240. (doi:10.1021/ac8002006)

Yin, H., Zhang, X.L., Pattrick, N., Klauke, N., Cordingley, H.C., Haswell, S.J., and Cooper, J.M. (2007) Influence of hydrodynamic conditions on quantitative cellular assays in microfluidic systems. Analytical Chemistry, 79(18), pp. 7139-7144. (doi:10.1021/ac071146k)

Zhang, X.L., Yin, H., Cooper, J.M., and Haswell, S.J. (2006) A microfluidic-based system for analysis of single cells based on Ca2+ flux. Electrophoresis, 27(24), pp. 5093-5100. (doi:10.1002/elps.200600390)

Dyadyusha, L., Yin, H., Jaiswal, S., Brown, T., Baumberg, J.J., Booy, F.P., and Melvin, T. (2005) Quenching of CdSe quantum dot emission, a new approach for biosensing. Chemical Communications(25), pp. 3201-3203. (doi:10.1039/B500664c) (PMID:15968371)

Yin, H.B., Brown, T., Greef, R., Wilkinson, J.S., and Melvin, T. (2004) Chemical modification and micropatterning of Si(1 0 0) with oligonucleotides. Microelectronic Engineering, 73-74, pp. 830-836. (doi:10.1016/j.mee.2004.03.060)

Doneva, T.A., Yin, H.B., Stephens, P., Bowen, W.R., and Thomas, D.W. (2004) Development and AFM study of porous scaffolds for wound healing applications. Spectroscopy, 18(4), pp. 587-596. (doi:10.1155/2004/251698)

Yin, H.B., Brown, T., Wilkinson, J.S., Eason, R.W., and Melvin, T. (2004) Submicron patterning of DNA oligonucleotides on silicon. Nucleic Acids Research, 32(14), e118. (doi:10.1093/nar/gnh113) (PMID:15314186) (PMCID:PMC514397)

Bowen, W. R., Doneva, T. A., and Yin, H.B. (2002) Atomic force microscopy studies of membrane—solute interactions (fouling). Desalination, 146(1-3), pp. 97-102. (doi:10.1016/S0011-9164(02)00496-4)

Bowen, W. R., Doneva, T. A., and Yin, H. (2002) The effect of sulfonated poly(ether ether ketone) additives on membrane formation and performance. Desalination, 145(1-3), pp. 39-45. (doi:10.1016/S0011-9164(02)00364-8)

Bowen, W. R., Doneva, T. A., and Yin, H.-B. (2002) Separation of humic acid from a model surface water with PSU/SPEEK blend UF/NF membranes. Journal of Membrane Science, 206(1-2), pp. 417-429. (doi:10.1016/S0376-7388(01)00786-4)

Bowen, W. R., Doneva, T. A., and Yin, H.B. (2001) Polysulfone — sulfonated poly(ether ether) ketone blend membranes: systematic synthesis and characterisation. Journal of Membrane Science, 181(2), pp. 253-263. (doi:10.1016/S0376-7388(00)00541-X)

Book Sections

Song, Y., Li, B., Qiu, Y., and Yin, H. (2015) Single bacteria studies using microfluidics. In: Hydrocarbon and Lipid Microbiology Protocols. Series: Springer Protocols Handbooks. Springer. (doi:10.1007/8623_2015_70)

Yin, H., McPhee, G., and Dobson, P. (2009) AFM and development of (bio) fouling-resistant membranes. In: Bowen, W.R. and Hilal, N. (eds.) Atomic Force Microscopy in Process Engineering: Introduction to AFM for Improved Processes and Products. Butterworth-Heinemann: Oxford, UK. ISBN 9781856175173

Yin, H., McPhee, G., and Dobson, P. (2009) Micro/nanoengineering and AFM for cellular sensing. In: Bowen, W.R. and Hilal, N. (eds.) Atomic Force Microscopy in Process Engineering: Introduction to AFM for Improved Processes and Products. Butterworth-Heinemann: Oxford, UK. ISBN 9781856175173

Conference Proceedings

Yuan, X., Chim, Y., and Yin, H. (2014) Linking cell shape, elasticity and fate: in vitro re-differentiation of chondrocytes. In: Optical Elastography and Tissue Biomechanics, San Francisco, CA, USA, 1-2 Feb 2014, 89460M. (doi:10.1117/12.2039859)

Hu, Z., Glidle, A., Ironside, C.N., Sorel, M., Strain, M.J., and Yin, H. (2011) On-chip micro-spectrometer for fluorescence bio-sensing. In: CLEO Europe 2011, Munich, Germany, 22-26 May 2011, (doi:10.1109/CLEOE.2011.5943698)

Zarowna-Dabrowska, A. et al. (2010) Micromanipulation of beads and CHO cells using micro light emitting diode arrays to control a miniaturised optoelectronic tweezers device. In: IOP Photon10, Southampton, UK, 23-26 Aug 2010,

Zarowna-Dabrowska, A. et al. (2010) Miniaturised optoelectronic tweezers controlled by GaN micro light emitting diode arrays. In: 23rd Annual Meeting of the IEEE Photonics Society, Denver, CO, 7-11 Nov 2010,

Melvin, T. et al. (2006) DNA, Nanoparticles and Photons - New Approaches for Clinical Diagnostics. In: 2006 International Symposium on Biophotonics, Nanophotonics and Metamaterials, Hangzhou, China, 16-18 Oct 2006, pp. 20-21. ISBN 9780780397743 (doi:10.1109/METAMAT.2006.334986)

Yin, H. B., Brown, T., Greef, R., Mailis, S., Eason, R., Wilkinson, J. S., and Melvin, T. (2004) Photopatterning of DNA oligonucleotides on silicon surfaces with micron-scale dimensions. In: Biophotonics New Frontier: From Genome to Proteome, Strasbourg, France, 26 Apr 2004, ISBN 9780819453846 (doi:10.1117/12.545736)

This list was generated on Wed Mar 29 23:55:54 2017 BST.