Dr Martin Mcbride

  • Senior Lecturer - Systems Medicine Coordinator (Institute of Cardiovascular and Medical Sciences)
  • Associate (School of Medicine)

telephone: 01413302911
email: Martin.McBride@glasgow.ac.uk

Research interests

I currently hold a lectureship that is externally funded by the British Heart Foundation. I completed my undergraduate and postgraduate training in Genetics at the University of Glasgow and received post-doctoral research training in various laboratories before joining Professor Dominiczak’s group. My principle research interests include identification of genetic determinants underlying complex disease, including hypertension and stroke, in experimental genetics and medicine. I have established microarray gene expression profiling on both the Affymetrix and Illumina platforms, microRNA profiling and have generated some high through put proteomics data with collaborators in the Sir Henry Wellcome Functional Genomics Facility, University of Glasgow. As well as an interest in identifying disrupted biological pathways from this data I have a major interest to integrate all three levels of biological information. Through external collaborations I work closely with bioinformaticians in Glasgow, Edinburgh and Imperial College, London and have particularly strong links with Ensembl.

Through the Euratools consortium, I was invited to present at a key note lecture at the Cardiovascular Genetics workshop at the European Council for Cardiovascular Research meeting (12th-14th October 2007, La Colle sur Loup, Nice, France). Through my interest in biological pathways and transcriptional networks I was invited to present at the Ingenuity Pathway Analysis User meeting (Basle Switzerland, 2007). In addition, I am a member of the British Hypertension Society and have chaired sessions at the International Society of Hypertension Fukuoka, Japan (2006) and various other local meetings.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Investigation of Osteopontin as a candidate gene for left ventricular hypertrophy
    British Heart Foundation
    2014 - 2017
     
  • A systems biology biomarkers approach to the differentiation of recombinant human erythropoietin doping from confounding factors
    World Anti Doping Agency
    2014 - 2015
     
  • Genetic, molecular and functional dissection of a novel pathway for hypertension: Uromodulin, renal function, sodium homeostasis and blood pressure.
    British Heart Foundation
    2013 - 2016
     
  • Genomics and proteomics of hypertension and its vascular complications: the pathwayomic strategies.
    British Heart Foundation
    2008 - 2011
     

Publications

List by: Type | Date

Jump to: 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
Number of items: 50.

2014

Sampson, A. K., Mohammed, D., Beattie, W., Graham, D., Kenyon, C. J., Al-Dujaili, E. A.S., Guryev, V., McBride, M. W., and Dominiczak, A. F. (2014) Introgressed chromosome 2 quantitative trait loci restores aldosterone regulation and reduces response to salt in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 32(10). pp. 2013-2021. (doi:10.1097/HJH.0000000000000300)

Graham, L. A. et al. (2014) Validation of uromodulin as a candidate gene for human essential hypertension. Hypertension, 63(3). pp. 551-558. (doi:10.1161/HYPERTENSIONAHA.113.01423)

Bailey, E. L., McBride, M. W., Crawford, W., McClure, J. D., Graham, D., Dominiczak, A. F., Sudlow, C. L.M., Smith, C., and Wardlaw, J. M. (2014) Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke. Neuropathology and Applied Neurobiology, 40(7). pp. 855-872. (doi:10.1111/nan.12116)

Padmanabhan, S., Graham, L., Ferreri, N. R., Graham, D., McBride, M., and Dominiczak, A. (2014) Uromodulin, an emerging novel pathway for blood pressure regulation and hypertension. Hypertension, 64(5). pp. 918-923. (doi:10.1161/HYPERTENSIONAHA.114.03132)

Sampson, A.K., Andrews, K.L., Graham, D., McBride, M.W., Head, G.A., Thomas, M.C., Chin-Dusting, J.P.F., Dominiczak, A., and Jennings, G.L. (2014) Origin of the y chromosome influences intrarenal vascular responsiveness to angiotensin i and angiotensin (1-7) in stroke-prone spontaneously hypertensive rats. Hypertension, 64(6). pp. 1376-1383. (doi:10.1161/HYPERTENSIONAHA.114.03756)

2013

Ramdas, V., McBride, M., Denby, L., and Baker, A. H. (2013) Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. American Journal of Pathology, 183(6). pp. 1885-1896. (doi:10.1016/j.ajpath.2013.08.027)

Atanur, S.S. et al. (2013) Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat. Cell, 154(3). pp. 691-703. (doi:10.1016/j.cell.2013.06.040)

Baud, A. et al. (2013) Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nature Genetics, 45(7). pp. 767-775. (doi:10.1038/ng.2644)

Howard, L., Mackenzie, R. M., Pchelintsev, N. A., McBryan, T., McClure, J. D., McBride, M. W., Kane, N. M., Adams, P. D., Milligan, G., and Baker, A. H. (2013) Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment. Stem Cell Research and Therapy, 4(2). Art. 36. (doi:10.1186/scrt192)

Koh-Tan, H.H. C., McBride, M. W., McClure, J. D., Beattie, E., Young, B., Dominiczak, A. F., and Graham, D. (2013) Interaction between chromosome 2 and 3 regulates pulse pressure in the stroke-prone spontaneously hypertensive rat. Hypertension, 62(1). pp. 33-40. (doi:10.1161/HYPERTENSIONAHA.111.00814)

2012

Mackenzie, R.M., Sandrim, V.C., Carty, D.M., McClure, J.D., Freeman, D.J., Dominiczak, A.F., McBride, M.W., and Delles, C. (2012) Endothelial FOS expression and pre-eclampsia. BJOG: An International Journal of Obstetrics and Gynaecology, 119(13). pp. 1564-1571. (doi:10.1111/1471-0528.12016)

2011

Nash, B., Thomson, C.E., Linington, C., Arthur, A.T., McClure, J.D., McBride, M.W., and Barnett, S.C. (2011) Functional duality of astrocytes in myelination. Journal of Neuroscience, 31(37). pp. 13028-13038. (doi:10.1523/JNEUROSCI.1449-11.2011)

Denby, L. et al. (2011) miR-21 and miR-214 are consistently modulated during renal injury in rodent models. American Journal of Pathology, 179(2). pp. 661-672. (doi:10.1016/j.ajpath.2011.04.021)

Yogi, A., Callera, G.E., Aranha, A.B., Antunes, T.T., Graham, D., McBride, M., Dominiczak, A., and Touyz, R.M. (2011) Sphingosine-1-Phosphate-Induced Inflammation Involves Receptor Tyrosine Kinase Transactivation in Vascular Cells: Upregulation in Hypertension. Hypertension, 57(4). pp. 809-818. (doi:10.1161/HYPERTENSIONAHA.110.162719)

2010

Hopcroft, L. E.M., McBride, M. W., Harris, K. J., Sampson, A. K., McClure, J. D., Graham, D. , Young, G., Holyoake, T. L., Girolami, M. A., and Dominiczak, A. F. (2010) Predictive response-relevant clustering of expression data provides insights into disease processes. Nucleic Acids Research, 38(20). pp. 6831-6840. (doi:10.1093/nar/gkq550)

Craig, M. A., McBride, M. W., Smith, G., George, S., and Baker, A. (2010) Dysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat. Journal of Molecular and Cellular Cardiology, 48(6). pp. 1121-1128. (doi:10.1016/j.yjmcc.2010.01.017)

Delles, C., McBride, M.W., Graham, D., Padmanabhan, S., and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802(12). pp. 1299-1308. (doi:10.1016/j.bbadis.2009.12.006)

Fairley, S., McClure, J., Hanlon, N., Irving, R., McBride, M., Dominiczak, A., and Hunt, E. (2010) Mapping affymetrix microarray probes to the rat genome via a persistent index. International Journal of Knowledge Discovery in Bioinformatics, 1(1). pp. 48-65. (doi:10.4018/jkdb.2010100204)

McBride, M., Hopcroft, L., Harris, K., McClure, J., Graham, D., Girolami, M., and Dominiczak, M. (2010) Insights into Salt-Sensitive Hypertension Using Response-Relevant Clustering. In: 20th Annual Meeting of the European Society of Hypertension, Oslo, Norway, 18-21 June, E342-E342.

Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6(10). e1001177. (doi:10.1371/journal.pgen.1001177)

Taurino, C., Miller, W.H., McBride, M.W., McClure, J.D., Khanin, R., Moreno Zulategui, M.U., Dymott, J., Delles, C., and Dominiczak, A.F. (2010) Gene expression profiling in whole blood of patients with coronary artery disease. Clinical Science, 119(8). pp. 335-343. (doi:10.1042/CS20100043)

2009

Methven, L., McBride, M., Wallace, G.A., and McGrath, J.C. (2009) The alpha1B/D-adrenoceptor knockout mouse permits isolation of the vascular alpha1A-adrenoceptor and elucidates its relationship to the other subtypes. British Journal of Pharmacology, 158 (1). pp. 209-224. (doi:10.1111/j.1476-5381.2009.00269.x)

Padmanabhan, S., Hastie, C., Sainsbury, C., McBride, M. W., Connell, J. M., and Dominiczak, A. F. (2009) The cat, the fly and the beetle - why genetics needs a semantic education. International Journal of Semantic Computing, 3(1). pp. 77-90. (doi:10.1142/S1793351X09000665)

Koh-Tan, H., Graham, D., Hamilton, C., Nicoll, G., Fields, L., McBride, M., Young, B., Young, B., and Dominiczak, A. (2009) Renal and vascular glutathione S-transferase mu is not affected by pharmacological intervention to reduce systolic blood pressure. Journal of Hypertension, 27(8). pp. 1575-1584. (doi:10.1097/HJH.0b013e32832cc5a1 )

Masson, R. et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53(4). pp. 694-700. (doi:10.1161/HYPERTENSIONAHA.108.122333)

Methven, L., McBride, M., Wallace, G.A., and McGrath, J.C. (2009) The α1B/D-adrenoceptor knockout mouse permits isolation of the vascular α1A-adrenoceptor and elucidates its relationship to the other subtypes. British Journal of Pharmacology, 158(1). pp. 209-224. (doi:10.1111/j.1476-5381.2009.00269.x)

2008

Delles, C., McBride, M.W., Padmanabhan, S., and Dominiczak, A.F. (2008) The genetics of cardiovascular disease. Trends in Endocrinology and Metabolism, 19(9). pp. 309-316. (doi:10.1016/j.tem.2008.07.010 )

Delles, C. et al. (2008) Glutathione S-transferase variants and hypertension. Journal of Hypertension, 26(7). pp. 1343-1352. (doi:10.1097/HJH.0b013e3282fe1d67)

Tian, T., McBride, M.W., Graham, D., Touyz, R., and Dominiczak, A.F. (2008) A systems biology approach for the sphingosine-1-phosphate signal transduction in vascular smooth muscle cell. Journal of Hypertension, 26(Suppl.). S148-S148.

Tonyz, R., Aranha, A., Yogi, A., Graham, D., McBride, M., Callera, G., Montezano, A., Coimbra, T., and Dominiczak, A. (2008) Increased vascular sphingosine-1-phosphate signaling in SHRSP is due to post-receptor mechanisms. Journal of Hypertension, 26(Suppl.). S329-S329.

2007

Graham, D. et al. (2007) Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat - Congenic analysis. Hypertension, 50(6). pp. 1134-1141. (doi:10.1161/HYPERTENSIONAHA.107.095349)

Jakubowska, J., Hunt, E., Chalmers, M., McBride, M., and Dominiczak, A. F. (2007) VisGenome: visualization of single and comparative genome representations. Bioinformatics, 23(19). pp. 2641-2642. (doi:10.1093/bioinformatics/btm394)

2006

McBride, M., Graham, D., Delles, C., and Dominiczak, A. (2006) Functional genomics in hypertension. Current Opinion in Nephrology and Hypertension, 15(2). pp. 145-151. (doi:10.1097/01.mnh.0000203188.57513.3f)

2005

Adler, J., Arribas, S., Briones, A., Daly, C., Deighan, C., McBride, M., McGrath, J., Shafaroudi, M., and Vila, E. (2005) New aspects of vascular remodelling: the involvement of all vascular cell types. Experimental Physiology, 90. pp. 469-475. (doi:10.1113/expphysiol.2005.030130)

Daly, C., Deighan, C., Macmillan, J., McBride, M., McGrath, J., Shafaroudi, M., and Wokoma, A. (2005) Two 'knockout' mouse models demonstrate that aortic vasodilatation is mediated via alpha(2A)-adrenoceptors located on the endothelium. Journal of Pharmacology and Experimental Therapeutics, 314(2). pp. 804-810.

Dominiczak, A. F., Graham, D., McBride, M. W., Brain, N. J.R., Lee, W. K., Charchar, F. J., Tomaszewski, M., Delles, C., and Hamilton, C. A. (2005) Corcoran Lecture. Cardiovascular genomics and oxidative stress. Hypertension, 45(4). pp. 636-642. (doi:10.1161/01.HYP.0000154253.53134.09)

McBride, M. et al. (2005) Reduction of Gstm1 expression in the stroke-prone spontaneously hypertension rat contributes to increased oxidative stress. Hypertension, 45(4). pp. 786-792. (doi:10.1161/01.HYP.0000154879.49245.39)

Shafaroudi, M., McBride, M., Deighan, C., Wokoma, A., Macmillan, J., Daly, C., and McGrath, J. (2005) Two "knockout" mouse models demonstrate that aortic vasodilatation is mediated via alpha(2A)-adrenoceptors located on the endothelium. Journal of Pharmacology and Experimental Therapeutics, 314. pp. 804-810. (doi:10.1124/jpet.105.085944)

Strahorn, P., Graham, D., Charchar, F., Sattar, N., McBride, M., and Dominiczak, A. (2005) Genetic determinants of metabolic syndrome components in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 23(12). pp. 2179-2186.

Ye, P. et al. (2005) The aldosterone synthase (CYP11B2) and 11 beta-hydroxylase (CYP11B1) genes are not expressed in the rat heart. Endocrinology, 146(12). pp. 5287-5293.

2004

McBride, M.W., Charchar, F.J., Graham, D., Miller, W.H., Strahorn, P., Carr, F.J., and Dominiczak, A.F. (2004) Functional genomics in rodent models of hypertension. Journal of Physiology, 554(1). pp. 56-63. (doi:10.1113/jphysiol.2003.049361)

Dominiczak, A., Brain, N., Charchar, F., McBride, M., Hanlon, N., and Lee, W. (2004) Genetics of hypertension: Lessons learnt from Mendelian and polygenic syndromes. Clinical and Experimental Hypertension, 26(7-8). pp. 611-620. (doi:10.1081/CEH-200031939)

Hamilton, C., Miller, W., Al Benna, S., Brosnan, M., Drummond, R., McBride, M., and Dominiczak, A. (2004) Strategies to reduce oxidative stress in cardiovascular disease. Clinical Science, 106. pp. 219-234. (doi:10.1042/CS20030379)

2003

Dominiczak, A.F., and McBride, M.W. (2003) Genetics of common polygenic stroke. Nature Genetics, 35(2). pp. 116-117.

McBride, M., Carr, F., Graham, D., Anderson, N., Clark, J., Lee, W., Charchar, F., Brosnan, M., and Dominiczak, A. (2003) Microarray analysis of rat chromosome 2 congenic strains. Hypertension, 41. pp. 847-853. (doi:10.1161/01.HYP.0000047103.07205.03)

2002

Ali, Z., Daly, C., Deighan, C., McBride, M., McGee, A., McGrath, J., and Mennie, D. (2002) A knockout approach indicates a minor vasoconstrictor role for vascular alpha(1B)-adrenoceptors in mouse. Physiological Genomics, 9. pp. 85-91. (doi:10.1152/physiolgenomics.00065.2001)

Carr, F.J., Negrin, C.D., Clark, J.S., Graham, D., McBride, M.W., Anderson, N.W., and Dominiczak, A.F. (2002) Chromosome 2 reciprocal congenic strains to evaluate the effect of the genetic background on blood pressure. Scottish Medical Journal, 47(1). pp. 7-9. (doi: 10.1177/003693300204700104 )

Carr, F., McBride, M., Carswell, H., Graham, D., Strahorn, P., Clark, J., Charchar, F., and Dominiczak, A. (2002) Genetic aspects of stroke: Human and experimental studies. Journal of Cerebral Blood Flow and Metabolism, 22(7). pp. 767-773. (doi:10.1097/00004647-200207000-00001)

McBride, M., Carswell, H., Graham, D., Carr, F., Charchar, F., Macrae, I., and Dominiczak, A. (2002) Genetic and gender determinants of cerebrovascular disease. Seminars in Nephrology, 22. pp. 127-134. (doi:10.1053/snep.2002.30213)

2001

Negrin, C., McBride, M., Carswell, H., Graham, D., Carr, F., Clark, J., Jeffs, B., Anderson, N., Macrae, I., and Dominiczak, A. (2001) Reciprocal consomic strains to evaluate Y chromosome effects. Hypertension, 37. pp. 391-397. (doi:10.1161/01.HYP.37.2.391 )

This list was generated on Mon Mar 2 09:45:17 2015 GMT.
Number of items: 50.

Articles

Sampson, A. K., Mohammed, D., Beattie, W., Graham, D., Kenyon, C. J., Al-Dujaili, E. A.S., Guryev, V., McBride, M. W., and Dominiczak, A. F. (2014) Introgressed chromosome 2 quantitative trait loci restores aldosterone regulation and reduces response to salt in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 32(10). pp. 2013-2021. (doi:10.1097/HJH.0000000000000300)

Graham, L. A. et al. (2014) Validation of uromodulin as a candidate gene for human essential hypertension. Hypertension, 63(3). pp. 551-558. (doi:10.1161/HYPERTENSIONAHA.113.01423)

Bailey, E. L., McBride, M. W., Crawford, W., McClure, J. D., Graham, D., Dominiczak, A. F., Sudlow, C. L.M., Smith, C., and Wardlaw, J. M. (2014) Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke. Neuropathology and Applied Neurobiology, 40(7). pp. 855-872. (doi:10.1111/nan.12116)

Padmanabhan, S., Graham, L., Ferreri, N. R., Graham, D., McBride, M., and Dominiczak, A. (2014) Uromodulin, an emerging novel pathway for blood pressure regulation and hypertension. Hypertension, 64(5). pp. 918-923. (doi:10.1161/HYPERTENSIONAHA.114.03132)

Sampson, A.K., Andrews, K.L., Graham, D., McBride, M.W., Head, G.A., Thomas, M.C., Chin-Dusting, J.P.F., Dominiczak, A., and Jennings, G.L. (2014) Origin of the y chromosome influences intrarenal vascular responsiveness to angiotensin i and angiotensin (1-7) in stroke-prone spontaneously hypertensive rats. Hypertension, 64(6). pp. 1376-1383. (doi:10.1161/HYPERTENSIONAHA.114.03756)

Ramdas, V., McBride, M., Denby, L., and Baker, A. H. (2013) Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. American Journal of Pathology, 183(6). pp. 1885-1896. (doi:10.1016/j.ajpath.2013.08.027)

Atanur, S.S. et al. (2013) Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat. Cell, 154(3). pp. 691-703. (doi:10.1016/j.cell.2013.06.040)

Baud, A. et al. (2013) Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nature Genetics, 45(7). pp. 767-775. (doi:10.1038/ng.2644)

Howard, L., Mackenzie, R. M., Pchelintsev, N. A., McBryan, T., McClure, J. D., McBride, M. W., Kane, N. M., Adams, P. D., Milligan, G., and Baker, A. H. (2013) Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment. Stem Cell Research and Therapy, 4(2). Art. 36. (doi:10.1186/scrt192)

Koh-Tan, H.H. C., McBride, M. W., McClure, J. D., Beattie, E., Young, B., Dominiczak, A. F., and Graham, D. (2013) Interaction between chromosome 2 and 3 regulates pulse pressure in the stroke-prone spontaneously hypertensive rat. Hypertension, 62(1). pp. 33-40. (doi:10.1161/HYPERTENSIONAHA.111.00814)

Mackenzie, R.M., Sandrim, V.C., Carty, D.M., McClure, J.D., Freeman, D.J., Dominiczak, A.F., McBride, M.W., and Delles, C. (2012) Endothelial FOS expression and pre-eclampsia. BJOG: An International Journal of Obstetrics and Gynaecology, 119(13). pp. 1564-1571. (doi:10.1111/1471-0528.12016)

Nash, B., Thomson, C.E., Linington, C., Arthur, A.T., McClure, J.D., McBride, M.W., and Barnett, S.C. (2011) Functional duality of astrocytes in myelination. Journal of Neuroscience, 31(37). pp. 13028-13038. (doi:10.1523/JNEUROSCI.1449-11.2011)

Denby, L. et al. (2011) miR-21 and miR-214 are consistently modulated during renal injury in rodent models. American Journal of Pathology, 179(2). pp. 661-672. (doi:10.1016/j.ajpath.2011.04.021)

Yogi, A., Callera, G.E., Aranha, A.B., Antunes, T.T., Graham, D., McBride, M., Dominiczak, A., and Touyz, R.M. (2011) Sphingosine-1-Phosphate-Induced Inflammation Involves Receptor Tyrosine Kinase Transactivation in Vascular Cells: Upregulation in Hypertension. Hypertension, 57(4). pp. 809-818. (doi:10.1161/HYPERTENSIONAHA.110.162719)

Hopcroft, L. E.M., McBride, M. W., Harris, K. J., Sampson, A. K., McClure, J. D., Graham, D. , Young, G., Holyoake, T. L., Girolami, M. A., and Dominiczak, A. F. (2010) Predictive response-relevant clustering of expression data provides insights into disease processes. Nucleic Acids Research, 38(20). pp. 6831-6840. (doi:10.1093/nar/gkq550)

Craig, M. A., McBride, M. W., Smith, G., George, S., and Baker, A. (2010) Dysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat. Journal of Molecular and Cellular Cardiology, 48(6). pp. 1121-1128. (doi:10.1016/j.yjmcc.2010.01.017)

Delles, C., McBride, M.W., Graham, D., Padmanabhan, S., and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802(12). pp. 1299-1308. (doi:10.1016/j.bbadis.2009.12.006)

Fairley, S., McClure, J., Hanlon, N., Irving, R., McBride, M., Dominiczak, A., and Hunt, E. (2010) Mapping affymetrix microarray probes to the rat genome via a persistent index. International Journal of Knowledge Discovery in Bioinformatics, 1(1). pp. 48-65. (doi:10.4018/jkdb.2010100204)

Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6(10). e1001177. (doi:10.1371/journal.pgen.1001177)

Taurino, C., Miller, W.H., McBride, M.W., McClure, J.D., Khanin, R., Moreno Zulategui, M.U., Dymott, J., Delles, C., and Dominiczak, A.F. (2010) Gene expression profiling in whole blood of patients with coronary artery disease. Clinical Science, 119(8). pp. 335-343. (doi:10.1042/CS20100043)

Methven, L., McBride, M., Wallace, G.A., and McGrath, J.C. (2009) The alpha1B/D-adrenoceptor knockout mouse permits isolation of the vascular alpha1A-adrenoceptor and elucidates its relationship to the other subtypes. British Journal of Pharmacology, 158 (1). pp. 209-224. (doi:10.1111/j.1476-5381.2009.00269.x)

Padmanabhan, S., Hastie, C., Sainsbury, C., McBride, M. W., Connell, J. M., and Dominiczak, A. F. (2009) The cat, the fly and the beetle - why genetics needs a semantic education. International Journal of Semantic Computing, 3(1). pp. 77-90. (doi:10.1142/S1793351X09000665)

Koh-Tan, H., Graham, D., Hamilton, C., Nicoll, G., Fields, L., McBride, M., Young, B., Young, B., and Dominiczak, A. (2009) Renal and vascular glutathione S-transferase mu is not affected by pharmacological intervention to reduce systolic blood pressure. Journal of Hypertension, 27(8). pp. 1575-1584. (doi:10.1097/HJH.0b013e32832cc5a1 )

Masson, R. et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53(4). pp. 694-700. (doi:10.1161/HYPERTENSIONAHA.108.122333)

Methven, L., McBride, M., Wallace, G.A., and McGrath, J.C. (2009) The α1B/D-adrenoceptor knockout mouse permits isolation of the vascular α1A-adrenoceptor and elucidates its relationship to the other subtypes. British Journal of Pharmacology, 158(1). pp. 209-224. (doi:10.1111/j.1476-5381.2009.00269.x)

Delles, C., McBride, M.W., Padmanabhan, S., and Dominiczak, A.F. (2008) The genetics of cardiovascular disease. Trends in Endocrinology and Metabolism, 19(9). pp. 309-316. (doi:10.1016/j.tem.2008.07.010 )

Delles, C. et al. (2008) Glutathione S-transferase variants and hypertension. Journal of Hypertension, 26(7). pp. 1343-1352. (doi:10.1097/HJH.0b013e3282fe1d67)

Tian, T., McBride, M.W., Graham, D., Touyz, R., and Dominiczak, A.F. (2008) A systems biology approach for the sphingosine-1-phosphate signal transduction in vascular smooth muscle cell. Journal of Hypertension, 26(Suppl.). S148-S148.

Tonyz, R., Aranha, A., Yogi, A., Graham, D., McBride, M., Callera, G., Montezano, A., Coimbra, T., and Dominiczak, A. (2008) Increased vascular sphingosine-1-phosphate signaling in SHRSP is due to post-receptor mechanisms. Journal of Hypertension, 26(Suppl.). S329-S329.

Graham, D. et al. (2007) Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat - Congenic analysis. Hypertension, 50(6). pp. 1134-1141. (doi:10.1161/HYPERTENSIONAHA.107.095349)

Jakubowska, J., Hunt, E., Chalmers, M., McBride, M., and Dominiczak, A. F. (2007) VisGenome: visualization of single and comparative genome representations. Bioinformatics, 23(19). pp. 2641-2642. (doi:10.1093/bioinformatics/btm394)

McBride, M., Graham, D., Delles, C., and Dominiczak, A. (2006) Functional genomics in hypertension. Current Opinion in Nephrology and Hypertension, 15(2). pp. 145-151. (doi:10.1097/01.mnh.0000203188.57513.3f)

Adler, J., Arribas, S., Briones, A., Daly, C., Deighan, C., McBride, M., McGrath, J., Shafaroudi, M., and Vila, E. (2005) New aspects of vascular remodelling: the involvement of all vascular cell types. Experimental Physiology, 90. pp. 469-475. (doi:10.1113/expphysiol.2005.030130)

Daly, C., Deighan, C., Macmillan, J., McBride, M., McGrath, J., Shafaroudi, M., and Wokoma, A. (2005) Two 'knockout' mouse models demonstrate that aortic vasodilatation is mediated via alpha(2A)-adrenoceptors located on the endothelium. Journal of Pharmacology and Experimental Therapeutics, 314(2). pp. 804-810.

Dominiczak, A. F., Graham, D., McBride, M. W., Brain, N. J.R., Lee, W. K., Charchar, F. J., Tomaszewski, M., Delles, C., and Hamilton, C. A. (2005) Corcoran Lecture. Cardiovascular genomics and oxidative stress. Hypertension, 45(4). pp. 636-642. (doi:10.1161/01.HYP.0000154253.53134.09)

McBride, M. et al. (2005) Reduction of Gstm1 expression in the stroke-prone spontaneously hypertension rat contributes to increased oxidative stress. Hypertension, 45(4). pp. 786-792. (doi:10.1161/01.HYP.0000154879.49245.39)

Shafaroudi, M., McBride, M., Deighan, C., Wokoma, A., Macmillan, J., Daly, C., and McGrath, J. (2005) Two "knockout" mouse models demonstrate that aortic vasodilatation is mediated via alpha(2A)-adrenoceptors located on the endothelium. Journal of Pharmacology and Experimental Therapeutics, 314. pp. 804-810. (doi:10.1124/jpet.105.085944)

Strahorn, P., Graham, D., Charchar, F., Sattar, N., McBride, M., and Dominiczak, A. (2005) Genetic determinants of metabolic syndrome components in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 23(12). pp. 2179-2186.

Ye, P. et al. (2005) The aldosterone synthase (CYP11B2) and 11 beta-hydroxylase (CYP11B1) genes are not expressed in the rat heart. Endocrinology, 146(12). pp. 5287-5293.

McBride, M.W., Charchar, F.J., Graham, D., Miller, W.H., Strahorn, P., Carr, F.J., and Dominiczak, A.F. (2004) Functional genomics in rodent models of hypertension. Journal of Physiology, 554(1). pp. 56-63. (doi:10.1113/jphysiol.2003.049361)

Dominiczak, A., Brain, N., Charchar, F., McBride, M., Hanlon, N., and Lee, W. (2004) Genetics of hypertension: Lessons learnt from Mendelian and polygenic syndromes. Clinical and Experimental Hypertension, 26(7-8). pp. 611-620. (doi:10.1081/CEH-200031939)

Hamilton, C., Miller, W., Al Benna, S., Brosnan, M., Drummond, R., McBride, M., and Dominiczak, A. (2004) Strategies to reduce oxidative stress in cardiovascular disease. Clinical Science, 106. pp. 219-234. (doi:10.1042/CS20030379)

Dominiczak, A.F., and McBride, M.W. (2003) Genetics of common polygenic stroke. Nature Genetics, 35(2). pp. 116-117.

McBride, M., Carr, F., Graham, D., Anderson, N., Clark, J., Lee, W., Charchar, F., Brosnan, M., and Dominiczak, A. (2003) Microarray analysis of rat chromosome 2 congenic strains. Hypertension, 41. pp. 847-853. (doi:10.1161/01.HYP.0000047103.07205.03)

Ali, Z., Daly, C., Deighan, C., McBride, M., McGee, A., McGrath, J., and Mennie, D. (2002) A knockout approach indicates a minor vasoconstrictor role for vascular alpha(1B)-adrenoceptors in mouse. Physiological Genomics, 9. pp. 85-91. (doi:10.1152/physiolgenomics.00065.2001)

Carr, F.J., Negrin, C.D., Clark, J.S., Graham, D., McBride, M.W., Anderson, N.W., and Dominiczak, A.F. (2002) Chromosome 2 reciprocal congenic strains to evaluate the effect of the genetic background on blood pressure. Scottish Medical Journal, 47(1). pp. 7-9. (doi: 10.1177/003693300204700104 )

Carr, F., McBride, M., Carswell, H., Graham, D., Strahorn, P., Clark, J., Charchar, F., and Dominiczak, A. (2002) Genetic aspects of stroke: Human and experimental studies. Journal of Cerebral Blood Flow and Metabolism, 22(7). pp. 767-773. (doi:10.1097/00004647-200207000-00001)

McBride, M., Carswell, H., Graham, D., Carr, F., Charchar, F., Macrae, I., and Dominiczak, A. (2002) Genetic and gender determinants of cerebrovascular disease. Seminars in Nephrology, 22. pp. 127-134. (doi:10.1053/snep.2002.30213)

Negrin, C., McBride, M., Carswell, H., Graham, D., Carr, F., Clark, J., Jeffs, B., Anderson, N., Macrae, I., and Dominiczak, A. (2001) Reciprocal consomic strains to evaluate Y chromosome effects. Hypertension, 37. pp. 391-397. (doi:10.1161/01.HYP.37.2.391 )

Conference Proceedings

McBride, M., Hopcroft, L., Harris, K., McClure, J., Graham, D., Girolami, M., and Dominiczak, M. (2010) Insights into Salt-Sensitive Hypertension Using Response-Relevant Clustering. In: 20th Annual Meeting of the European Society of Hypertension, Oslo, Norway, 18-21 June, E342-E342.

This list was generated on Mon Mar 2 09:45:17 2015 GMT.