Professor Godfrey Smith
- Professor of Cardiovascular Physiology, Director of Innovation, Engagement and Enterprise (Cardiovascular & Metabolic Health)
telephone:
01413305963
email:
Godfrey.Smith@glasgow.ac.uk
R415A Level 4, Institute of C&MS, West Medical Building, Glasgow G12 8QQ
https://orcid.org/0000-0003-4821-9741Research interests
Research Theme: Cardiac Diseases
Examination of the subcellular processes involved in excitation-contraction coupling of cardiac muscle using biophysical and biochemical techniques. Methodologies include fluorescence microscopy, electrophysiology and confocal imaging.
Research groups
Publications
2024
Kemi, O. J. , Hoydal, M. A., Haram, P. M., Smith, G. L. , Ellingsen, O., Koch, L. G., Britton, S. L. and Wisloff, U. (2024) Inherited physical capacity: Widening divergence from young to adult to old. Annals of the New York Academy of Sciences, (doi: 10.1111/nyas.15130) (PMID:38520387) (Early Online Publication)
Astrauskaite, G., Mohanan, S. , Williamson, L., Boland, E., Huethorst, E. , Kinegawa, R., Smith, G. and Muellenbroich, C. (2024) Remote Focusing for 2-photon Microscopy to Follow Action Potential Propagation Transmurally in Acute Rabbit Cardiac Slices. In: SPIE BiOS 2024, San Francisco, CA, USA, 27 January - 1 February 2024, ISBN 9781510669536 (doi: 10.1117/12.3002956)
Loughrey, C. et al. (2024) A novel ryanodine receptor 2 inhibitor, M201-A, enhances natriuresis, renal function and lusi-inotropic action: Pre-clinical and phase I study. British Journal of Pharmacology, (Accepted for Publication)
Freeman, M., Huethorst, E. , Boland, E., Dunne, M., Burton, F., Denning, C., Myles, R. and Smith, G. (2024) A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit. American Journal of Physiology: Heart and Circulatory Physiology, (doi: 10.1152/ajpheart.00657.2023) (PMID:38180449) (Early Online Publication)
2023
Da Silva Costa, A. et al. (2023) Electrically stimulated in vitro heart cell mimic of acute exercise reveals novel immediate cellular responses to exercise: Reduced contractility and metabolism, but maintained calcium cycling and increased myofilament calcium sensitivity. Cell Biochemistry and Function, 41(8), pp. 1147-1161. (doi: 10.1002/cbf.3847) (PMID:37665041)
Selli, A. L., Ghasemi, M., Watters, T., Burton, F., Smith, G. and Dietrichs, E. S. (2023) Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 31(1), 61. (doi: 10.1186/s13049-023-01134-5) (PMID:37880801) (PMCID:PMC10601188)
Eisner, D., Neher, E., Taschenberger, H. and Smith, G. (2023) Physiology of intracellular calcium buffering. Physiological Reviews, 103(4), pp. 2767-2845. (doi: 10.1152/physrev.00042.2022) (PMID:37326298)
Giommi, A., Gurgel, A. R. B., Smith, G. L. and Workman, A. J. (2023) Does the small conductance Ca2+-activated K+ current ISK flow under physiological conditions in rabbit and human atrial isolated cardiomyocytes? Journal of Molecular and Cellular Cardiology, 183, pp. 70-80. (doi: 10.1016/j.yjmcc.2023.09.002) (PMID:37704101)
Simitev, R. D. , Al dawoud, A., Aziz, M. H.N., Myles, R. and Smith, G. L. (2023) Phenomenological analysis of simple ion channel block in large populations of uncoupled cardiomyocytes. Mathematical Medicine and Biology, 40(2), pp. 175-198. (doi: 10.1093/imammb/dqad001) (PMID:36689769)
Lu, H. R., Van de Sande, D., Mohammadreza, G., Watters, T., Burton, F., Pham, L., Altrocchi, C., Gallacher, D. J. and Smith, G. (2023) Are more mature hiPSC-cardiomyocytes better for the detection of drug-induced cardiotoxicity? Biomolecules, 13(4), 676. (doi: 10.3390/biom13040676) (PMID:37189424) (PMCID:PMC10135569)
Kuo, C.-W. S. et al. (2023) Palmitoylation of the pore-forming subunit of Ca(v)1.2 controls channel voltage sensitivity and calcium transients in cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America, 120(7), e220788712. (doi: 10.1073/pnas.2207887120) (PMID:36745790) (PMCID:PMC9963536)
Alexander, C., Bishop, M. J., Gilchrist, R. J., Burton, F. L., Smith, G. L. and Myles, R. C. (2023) Initiation of ventricular arrhythmia in the acquired long QT syndrome. Cardiovascular Research, 119(2), pp. 465-476. (doi: 10.1093/cvr/cvac103) (PMID:35727943) (PMCID:PMC10064840)
2022
Saxena, P., Myles, R. C. , Smith, G. L. and Workman, A. J. (2022) Adrenoceptor sub-type involvement in Ca2+ current stimulation by noradrenaline in human and rabbit atrial myocytes. Pflügers Archiv European Journal of Physiology, 474(12), pp. 1311-1321. (doi: 10.1007/s00424-022-02746-z) (PMID:36131146) (PMCID:PMC9663393)
Lachaud, Q., Aziz, M. H. N., Burton, F. L., Macquaide, N. , Myles, R. C. , Simitev, R. D. and Smith, G. L. (2022) Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes. Cardiovascular Research, 118(15), pp. 3112-3125. (doi: 10.1093/cvr/cvab375) (PMID:35020837) (PMCID:PMC9732512)
Bruegmann, T., Smith, G. L. and Lehnart, S. E. (2022) Editorial: Cardiac optogenetics: Using light to observe and excite the heart. Frontiers in Physiology, 13, 1031062. (doi: 10.3389/fphys.2022.1031062) (PMID:36304575) (PMCID:PMC9593031)
Main, A. et al. (2022) Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies. Frontiers in Physiology, 13, 1023237. (doi: 10.3389/fphys.2022.1023237) (PMID:36277202) (PMCID:PMC9581287)
Fertig, B. et al. (2022) SUMOylation does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca2+. FEBS Journal, 289(20), pp. 6267-6285. (doi: 10.1111/febs.16537) (PMID:35633070) (PMCID:PMC9588612)
Malagueta-Vieira, L. et al. (2022) Metformin reduces potassium currents and prolongs repolarization in non-diabetic heart. International Journal of Molecular Sciences, 23(11), 6021. (doi: 10.3390/ijms23116021) (PMID:35682699) (PMCID:PMC9181026)
He, W. et al. (2022) Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size. Cardiovascular Research, 118(6), pp. 1535-1547. (doi: 10.1093/cvr/cvab204) (PMID:34132807)
Tibbo, A. J. et al. (2022) Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins. Journal of Molecular and Cellular Cardiology, 165, pp. 86-102. (doi: 10.1016/j.yjmcc.2022.01.001) (PMID:34999055) (PMCID:PMC8986152)
Dietrichs, E. S. and Smith, G. L. (2022) Prediction of ventricular arrhythmias by QRS/QTc - ratio in Citalopram or Escitalopram intoxication. Frontiers in Medicine, 9, 866454. (doi: 10.3389/fmed.2022.866454) (PMID:35372426) (PMCID:PMC8966227)
Huethorst, E. , Mortensen, P., Simitev, R. D. , Gao, H. , Pohjolainen, L., Talman, V., Ruskoaho, H., Burton, F. L., Gadegaard, N. and Smith, G. L. (2022) Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell derived cardiomyocytes. Journal of Physiology, 600(3), pp. 483-507. (doi: 10.1113/JP282228) (PMID:34761809) (PMCID:PMC9299844)
Faulkner-Jones, A., Zamora, V., Hortigon-Vinagre, M. P., Wang, W., Ardron, M., Smith, G. L. and Shu, W. (2022) A bioprinted heart-on-a-chip with human pluripotent stem cell-derived cardiomyocytes for drug evaluation. Bioengineering, 9(1), 32. (doi: 10.3390/bioengineering9010032) (PMID:35049741) (PMCID:PMC8773426)
2021
Müllenbroich, M. C. et al. (2021) Novel optics-based approaches for cardiac electrophysiology: a review. Frontiers in Physiology, 12, 769586. (doi: 10.3389/fphys.2021.769586) (PMID:34867476) (PMCID:PMC8637189)
Sveberg Dietrichs, E., Myles, R. and Smith, G. (2021) Is hypothermia more neuroprotective than avoiding fever after cardiac arrest? Cardiovascular Research, 117(12), e159-e161. (doi: 10.1093/cvr/cvab297) (PMID:34718465) (PMCID:PMC8562327)
Jabbour, R. J. et al. (2021) In vivo grafting of large engineered heart tissue patches for cardiac repair. JCI Insight, 6(15), e144068. (doi: 10.1172/jci.insight.144068) (PMID:34369384) (PMCID:PMC8410032)
Holmes, A. P. et al. (2021) The atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone. Heart Rhythm, 18(7), pp. 1212-1220. (doi: 10.1016/j.hrthm.2021.03.016) (PMID:33737232)
Bowman, P. R.T., Smith, G. L. and Gould, G. W. (2021) Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease? PeerJ, 9, e11485. (doi: 10.7717/peerj.11485) (PMID:34113491) (PMCID:PMC8162245)
Hortigon-Vinagre, M.P., Zamora, V., Burton, F. L. and Smith, G. L. (2021) The use of voltage sensitive dye di-4-ANEPPS and video-based contractility measurements to assess drug effects on excitation-contraction coupling in human induced pluripotent stem cell-derived cardiomyocytes. Journal of Cardiovascular Pharmacology, 77(3), pp. 280-290. (doi: 10.1097/FJC.0000000000000937) (PMID:33109927)
Mortensen, P., Gao, H. , Smith, G. and Simitev, R. D. (2021) Action potential propagation and block in a model of atrial tissue with myocyte-fibroblast coupling. Mathematical Medicine and Biology, 38(1), pp. 106-131. (doi: 10.1093/imammb/dqaa014) (PMID:33412587)
Da Silva Costa, A. , Mortensen, P., Hortigon-Vinagre, M. P., van der Heyden, M. A. G., Burton, F. L., Gao, H. , Simitev, R. D. and Smith, G. L. (2021) Electrophysiology of hiPSC-cardiomyocytes co-cultured with HEK cells expressing the inward rectifier channel. International Journal of Molecular Sciences, 22(12), 6621. (doi: 10.3390/ijms22126621)
Mortensen, P., Gao, H. , Smith, G. and Simitev, R. D. (2021) Addendum: Action potential propagation and block in a model of atrial tissue with myocyte-fibroblast coupling. Mathematical Medicine and Biology, 38(3), pp. 292-298. (doi: 10.1093/imammb/dqab005) (PMID:33959762)
2020
Dietrichs, E. S., McGlynn, K., Allan, A., Connolly, A., Bishop, M., Burton, F., Kettlewell, S., Myles, R. , Tveita, T. and Smith, G. L. (2020) Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology. Cardiovascular Research, 116(13), pp. 2081-2090. (doi: 10.1093/cvr/cvz309) (PMID:32031595) (PMCID:PMC7584464)
Salerno, S., Solvang-Garten, K., Smith, G. L. , Stølen, T. and Kelly, A. (2020) Two-photon excitation of FluoVolt allows improved interrogation of transmural electrophysiological function in the intact mouse heart. Progress in Biophysics and Molecular Biology, 154, pp. 11-20. (doi: 10.1016/j.pbiomolbio.2019.08.007) (PMID:31492464) (PMCID:PMC7322535)
Błyszczuk, P., Zuppinger, C., Costa, A. , Nurzynska, D., Di Meglio, F., Stellato, M., Agarkova, I., Smith, G. , Distler, O. and Kania, G. (2020) Activated cardiac fibroblasts control contraction of human fibrotic cardiac microtissues by a β-adrenoreceptor-dependent mechanism. Cells, 9(5), 1270. (doi: 10.3390/cells9051270) (PMID:32443848) (PMCID:PMC7290967)
Dietrichs, E. S., Tveita, T., Myles, R. and Smith, G. (2020) A novel ECG-biomarker for cardiac arrest during hypothermia. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 28, 27. (doi: 10.1186/s13049-020-00721-0) (PMID:32276599) (PMCID:PMC7149849)
de Korte, T. et al. (2020) Unlocking personalized biomedicine and drug discovery with human induced pluripotent stem cell–derived cardiomyocytes: fit for purpose or forever elusive? Annual Review of Pharmacology and Toxicology, 60(1), pp. 529-551. (doi: 10.1146/annurev-pharmtox-010919-023309) (PMID:31506008)
Li, Z. et al. (2020) General principles for the validation of proarrhythmia risk prediction models: an extension of the CiPA In Silico Strategy. Clinical Pharmacology and Therapeutics, 107(1), pp. 102-111. (doi: 10.1002/cpt.1647) (PMID:31709525) (PMCID:PMC6977398)
McArthur, L. , Riddell, A. , Chilton, L., Smith, G. L. and Nicklin, S. A. (2020) Regulation of connexin 43 by interleukin 1β in adult rat cardiac fibroblasts and effects in an adult rat cardiac myocyte: fibroblast co-culture model. Heliyon, 6(1), e03031. (doi: 10.1016/j.heliyon.2019.e03031) (PMID:31909243) (PMCID:PMC6940628)
2019
Gould, G. , Bowman, P. and Smith, G. (2019) Cardiac SNARE expression in health and disease. Frontiers in Endocrinology, 10, 881. (doi: 10.3389/fendo.2019.00881) (PMID:31920989) (PMCID:PMC6930865)
Bowman, P. R.T., Smith, G. L. and Gould, G. W. (2019) GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes. PLoS ONE, 14(7), e0217885. (doi: 10.1371/journal.pone.0217885) (PMID:31920989) (PMCID:PMC6930865)
Kettlewell, S., Saxena, P., Dempster, J., Colman, M. A., Myles, R. C. , Smith, G. L. and Workman, A. J. (2019) Dynamic‐clamping human and rabbit atrial calcium current: narrowing ICaL window abolishes early afterdepolarisations. Journal of Physiology, 597(14), pp. 3619-3638. (doi: 10.1113/JP277827) (PMID:31093979) (PMCID:PMC6767690)
Smith, G. L. and Eisner, D. A. (2019) Calcium buffering in the heart in health and disease. Circulation, 139(20), pp. 2358-2371. (doi: 10.1161/circulationaha.118.039329) (PMID:31082292) (PMCID:PMC6520234)
Ghouri, I. A., Kelly, A., Salerno, S., Garten, K., Stølen, T., Kemi, O.-J. and Smith, G. L. (2019) Corrigendum: Characterization of electrical activity in post-myocardial infarction scar tissue in rat hearts using multiphoton microscopy. Frontiers in Physiology, 10, 364. (doi: 10.3389/fphys.2019.00364) (PMID:31024333) (PMCID:PMC6461023)
Dietrichs, E. S., Tveita, T. and Smith, G. (2019) Hypothermia and cardiac electrophysiology: a systematic review of clinical and experimental data. Cardiovascular Research, 115(3), pp. 501-509. (doi: 10.1093/cvr/cvy305) (PMID:30544147)
Pfeiffer-Kaushik, E. R. et al. (2019) Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms. Journal of Pharmacological and Toxicological Methods, 99, 106612. (doi: 10.1016/j.vascn.2019.106612) (PMID:31319140)
2018
Lemme, M. et al. (2018) Atrial-like engineered heart tissue: an in vitro model of the human atrium. Stem Cell Reports, 11(6), pp. 1378-1390. (doi: 10.1016/j.stemcr.2018.10.008) (PMID:30416051) (PMCID:PMC6294072)
Connolly, A., Kelly, A., Campos, F. O., Myles, R. , Smith, G. and Bishop, M. J. (2018) Ventricular endocardial tissue geometry affects stimulus threshold and effective refractory period. Biophysical Journal, 115(12), pp. 2486-2498. (doi: 10.1016/j.bpj.2018.11.003) (PMID:30503533) (PMCID:PMC6301915)
Ghouri, I. A., Kelly, A., Salerno, S., Garten, K., Stølen, T., Kemi, O.-J. and Smith, G. L. (2018) Characterization of electrical activity in post-myocardial infarction scar tissue in rat hearts using multiphoton microscopy. Frontiers in Physiology, 9, 1454. (doi: 10.3389/fphys.2018.01454) (PMID:30386255) (PMCID:PMC6199960)
van Meer, B. J., Sala, L., Tertoolen, L. G.J., Smith, G. L. , Burton, F. L. and Mummery, C. L. (2018) Quantification of muscle contraction in vitro and in vivo using MUSCLEMOTION software: from stem cell-derived cardiomyocytes to zebrafish and human hearts. Current Protocols in Human Genetics, 99(1), e67. (doi: 10.1002/cphg.67) (PMID:30253059)
Blinova, K. et al. (2018) International multisite study of human-induced pluripotent stem cell-derived cardiomyocytes for drug proarrhythmic potential assessment. Cell Reports, 24(13), pp. 3582-3592. (doi: 10.1016/j.celrep.2018.08.079) (PMID:30257217) (PMCID:PMC6226030)
Bruegmann, T. and Smith, G. L. (2018) Macrophages: new players in cardiac ageing? Cardiovascular Research, 114(7), e47-e49. (doi: 10.1093/cvr/cvy047) (PMID:29800376)
Høydal, M. A. et al. (2018) Human cardiomyocyte calcium handling and transverse tubules in mid-stage of post-myocardial-infarction heart failure. ESC Heart Failure, 5(3), pp. 332-342. (doi: 10.1002/ehf2.12271) (PMID:29431258) (PMCID:PMC5933953)
Kelly, A., Salerno, S., Connolly, A., Bishop, M., Charpentier, F., Stølen, T. and Smith, G. L. (2018) Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome. Cardiovascular Research, 114(5), pp. 724-736. (doi: 10.1093/cvr/cvx244) (PMID:29267949) (PMCID:PMC5915948)
Boyden, P. A. and Smith, G. L. (2018) Ca2+ leak, what is it? Why should we care? Can it be managed? Heart Rhythm, 15(4), pp. 607-614. (doi: 10.1016/j.hrthm.2017.11.018) (PMID:29157722)
Malmo, V., Kelly, A., Garten, K. S., Stolen, T., Rolim, N. P. L., Wisloff, U., Smith, G. and Loennechen, J. P. (2018) Aerobic interval training prevents age-dependent vulnerability to atrial fibrillation in rodents. Frontiers in Physiology, 9, 206. (doi: 10.3389/fphys.2018.00206) (PMID:29593565)
Sala, L. et al. (2018) MUSCLEMOTION: a versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo. Circulation Research, 122(3), e5-e16. (doi: 10.1161/CIRCRESAHA.117.312067) (PMID:29282212) (PMCID:PMC5805275)
McCarroll, C. S. et al. (2018) Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction. Circulation, 137(1), pp. 57-70. (doi: 10.1161/CIRCULATIONAHA.117.028911) (PMID:29030345) (PMCID:PMC5757664)
Lachaud, Q., MacQuaide, N. , Burton, F. and Smith, G. (2018) High-throughput study of rabbit ventricle action potential populations in MI model. Biophysical Journal, 114(3.S1), 625A. (doi: 10.1016/j.bpj.2017.11.3377)
2017
Lei, C. L. et al. (2017) Tailoring mathematical models to stem-cell derived cardiomyocyte lines can improve predictions of drug-induced changes to their electrophysiology. Frontiers in Physiology, 8, 986. (doi: 10.3389/fphys.2017.00986) (PMID:29311950) (PMCID:PMC5732978)
Duncan, G., Firth, K., George, V., Hoang, M. D., Staniforth, A., Smith, G. and Denning, C. (2017) Drug-mediated shortening of action potentials in LQTS2 human induced pluripotent stem cell-derived cardiomyocytes. Stem Cells and Development, 26(23), pp. 1695-1705. (doi: 10.1089/scd.2017.0172) (PMID:28992755) (PMCID:PMC5706629)
Stevens, K., Denby, L., Patel, R. K., Mark, P. B. , Kettlewell, S., Smith, G. L. , Clancy, M. J., Delles, C. and Jardine, A. G. (2017) Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway. Nephrology Dialysis Transplantation, 32(10), pp. 1617-1627. (doi: 10.1093/ndt/gfw252) (PMID:27448672) (PMCID:PMC5837731)
Lu, H.R., Hortigon-Vinagre, M.P. , Zamora, V., Kopljar, I., De Bondt, A., Gallacher, D.J. and Smith, G. (2017) Application of optical action potentials in human induced pluripotent stem cells-derived cardiomyocytes to predict drug-induced cardiac arrhythmias. Journal of Pharmacological and Toxicological Methods, 87, pp. 53-67. (doi: 10.1016/j.vascn.2017.05.001) (PMID:28501647)
Saxena, P. et al. (2017) Correlation between human ether-a-go-go-related gene channel inhibition and action potential prolongation. British Journal of Pharmacology, 174(18), pp. 3081-3093. (doi: 10.1111/bph.13942) (PMID:28681507) (PMCID:PMC5573420)
Lamore, S. D. et al. (2017) Deconvoluting kinase inhibitor induced cardiotoxicity. Toxicological Sciences, 158(1), pp. 213-226. (doi: 10.1093/toxsci/kfx082) (PMID:28453775)
Blinova, K. et al. (2017) Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias. Toxicological Sciences, 155(1), pp. 234-247. (doi: 10.1093/toxsci/kfw200) (PMID:27701120)
2016
Fattah, C. et al. (2016) Gene therapy with Angiotensin-(1-9) preserves left ventricular systolic function after myocardial infarction. Journal of the American College of Cardiology, 68(24), pp. 2652-2666. (doi: 10.1016/j.jacc.2016.09.946) (PMID:27978950) (PMCID:PMC5158000)
Huethorst, E., Hortigon, M. , Zamora-Rodriguez, V., Reynolds, P.M. , Burton, F., Smith, G. and Gadegaard, N. (2016) Enhanced human-induced pluripotent stem cell derived cardiomyocyte maturation using a dual microgradient substrate. ACS Biomaterials Science and Engineering, 2(12), pp. 2231-2239. (doi: 10.1021/acsbiomaterials.6b00426) (PMID:27990488) (PMCID:PMC5155309)
Hortigon-Vinagre, M.P., Zamora, V., Burton, F.L., Green, J., Gintant, G.A. and Smith, G.L. (2016) The use of ratiometric fluorescence measurements of the voltage sensitive dye Di-4-ANEPPS to examine action potential characteristics and drug effects on human induced pluripotent stem cell-derived cardiomyocytes. Toxicological Sciences, 154(2), pp. 320-331. (doi: 10.1093/toxsci/kfw171) (PMID:27621282) (PMCID:PMC5139069)
Weinberger, F. et al. (2016) Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells. Science Translational Medicine, 8(363), 363ra148-363ra148. (doi: 10.1126/scitranslmed.aaf8781) (PMID:27807283)
Crocini, C. et al. (2016) Optogenetics design of mechanistically-based stimulation patterns for cardiac defibrillation. Scientific Reports, 6, 35628. (doi: 10.1038/srep35628) (PMID:27748433) (PMCID:PMC5066272)
Høydal, M. A. et al. (2016) Exercise training reverses myocardial dysfunction induced by CaMKIIδC overexpression by restoring Ca2+-homeostasis. Journal of Applied Physiology, 121(1), pp. 212-220. (doi: 10.1152/japplphysiol.00188.2016) (PMID:27231311)
Baumert, M., Porta, A., Vos, M. A., Malik, M., Couderc, J.-P., Laguna, P., Piccirillo, G., Smith, G. L. , Tereshchenko, L. G. and Volders, P. G.A. (2016) QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology. Europace, 18(6), pp. 925-944. (doi: 10.1093/europace/euv405) (PMID:26823389) (PMCID:PMC4905605)
Nisbet, A. M., Camelliti, P., Walker, N. L., Burton, F. L., Cobbe, S. M., Kohl, P. and Smith, G. L. (2016) Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: role of fibrosis and connexin remodelling. Journal of Molecular and Cellular Cardiology, 94, pp. 54-64. (doi: 10.1016/j.yjmcc.2016.03.011) (PMID:27021518) (PMCID:PMC4873602)
2015
Rog-Zielinska, E.A. et al. (2015) Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α. Cell Death and Differentiation, 22(7), pp. 1106-1116. (doi: 10.1038/cdd.2014.181) (PMID:25361084) (PMCID:PMC4572859)
McArthur, L. , Chilton, L., Smith, G. L. and Nicklin, S. A. (2015) Electrical consequences of cardiac myocyte: fibroblast coupling. Biochemical Society Transactions, 43(3), pp. 513-518. (doi: 10.1042/BST20150035) (PMID:26009200)
Smith, G. L. and MacQuaide, N. (2015) The direct actions of flecainide on the human cardiac ryanodine receptor: keeping open the debate on the mechanism of action of local anesthetics in CPVT. Circulation Research, 116(8), pp. 1284-1286. (doi: 10.1161/CIRCRESAHA.115.306298) (PMID:25858058)
Ghouri, I. A., Kelly, A., Burton, F. L., Smith, G. L. and Kemi, O. J. (2015) 2-photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca2+in intact mice, rat, and rabbit hearts. Journal of Biophotonics, 8(1-2), pp. 112-123. (doi: 10.1002/jbio.201300109)
MacCannell, K.A., Chilton, L., Smith, G.L. and Giles, W.R. (2015) Mathematical simulations of sphingosine-1-phosphate actions on mammalian ventricular myofibroblasts and myocytes. In: Dixon, I. M.C. and Wigle, J. T. (eds.) Cardiac Fibrosis and Heart Failure: Cause or Effect? Series: Advances in biochemistry in health and disease. Springer: Cham, pp. 299-322. ISBN 9783319174365 (doi: 10.1007/978-3-319-17437-2_16)
2014
Campbell, A. S., Johnstone, S. R., Baillie, G. S. and Smith, G. (2014) β-Adrenergic modulation of myocardial conduction velocity: Connexins vs. sodium current. Journal of Molecular and Cellular Cardiology, 77, pp. 147-154. (doi: 10.1016/j.yjmcc.2014.09.030)
Boyman, L., Chikando, A. C., Williams, G. S.B., Khairallah, R. J., Kettlewell, S., Ward, C. W., Smith, G. L. , Kao, J. P.Y. and Lederer, W. J. (2014) Calcium movement in cardiac mitochondria. Biophysical Journal, 107(6), pp. 1289-1301. (doi: 10.1016/j.bpj.2014.07.045)
Haviland, S., Cleemann, L., Kettlewell, S., Smith, G. L. and Morad, M. (2014) Diversity of mitochondrial Ca²⁺ signaling in rat neonatal cardiomyocytes: evidence from a genetically directed Ca²⁺ probe mitycam-E31Q. Cell Calcium, 56(3), pp. 133-146. (doi: 10.1016/j.ceca.2014.06.001) (PMID:24994483)
O-Uchi, J. et al. (2014) Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. Antioxidants and Redox Signaling, 21(6), pp. 863-879. (doi: 10.1089/ars.2013.5394)
Liu, T., Takimoto, E., Dimaano, V. L., DeMazumder, D., Kettlewell, S., Smith, G. , Sidor, A., Abraham, T. P. and O'Rourke, B. (2014) Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a guinea pig model of heart failure. Circulation Research, 115(1), pp. 44-54. (doi: 10.1161/CIRCRESAHA.115.303062) (PMID:24780171) (PMCID:PMC4219273)
Høydal, M.A., Stølen, T.O., Johnsen, A.B., Alvez, M., Catalucci, D., Condorelli, G., Koch, L.G., Britton, S.L., Smith, G.L. and Wisløff, U. (2014) Reduced aerobic capacity causes leaky ryanodine receptors that trigger arrhythmia in a rat strain artificially selected and bred for low aerobic running capacity. Acta Physiologica, 210(4), pp. 854-864. (doi: 10.1111/apha.12238)
Hohendanner, F., Walther, S., Maxwell, J. T., Kettlewell, S., Awad, S., Smith, G. , Lonchyna, V. A. and Blatter, L. A. (2014) Inositol-1,4,5-trisphosphate induced Ca2+release and excitation-contraction coupling in atrial myocytes from normal and failing hearts. Journal of Physiology, 593(6), pp. 1459-1477. (doi: 10.1113/jphysiol.2014.283226) (PMID:25416623)
Campbell, A. S., Burton, F. L., Baillie, G. and Smith, G. L. (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway. In: 58th Annual Meeting of the Biophysical-Society, San Francisco CA, USA, 15-19 Feb 2014, 119a.
Nisbet, A. M., Burton, F. L., Walker, N. L., Craig, M. A., Cheng, H., Hancox, J. C., Orchard, C. H. and Smith, G. L. (2014) Acidosis slows electrical conduction through the atrio-ventricular node. Frontiers in Physiology, 5(233), (doi: 10.3389/fphys.2014.00233)
2013
Hoydal, M.A., Kaurstad, G., Rolim, N.P., Johnsen, A.B., Alves, M., Koch, L.G., Britton, S.L., Stolen, T.O., Smith, G.L. and Wisloff, U. (2013) High inborn aerobic capacity does not protect the heart following myocardial infarction. Journal of Applied Physiology, 115(12), pp. 1788-1795. (doi: 10.1152/japplphysiol.00312.2013)
Kettlewell, S., Burton, F. L., Smith, G. L. and Workman, A. J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi: 10.1093/cvr/cvt087) (PMID:23568957) (PMCID:PMC3687753)
Lu, X., Ginsburg, K.S., Kettlewell, S., Bossuyt, J., Smith, G.L. and Bers, D.M. (2013) Measuring local gradients of intramitochondrial [Ca2+] in cardiac myocytes during sarcoplasmic reticulum Ca2+ release. Circulation Research, 112(3), pp. 424-431. (doi: 10.1161/CIRCRESAHA.111.300501)
Di Diego, J.M., Sicouri, S., Myles, R.C. , Burton, F., Smith, G.L. and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi: 10.1016/j.yjmcc.2012.10.017)
Elliott, E.B. et al. (2013) T. brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes. Cardiovascular Research, 100(2), pp. 325-335. (doi: 10.1093/cvr/cvt187) (PMID:23892734) (PMCID:PMC3797627)
Kelly, A., Ghouri, I.A., Kemi, O.J. , Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C. , Burton, F.L. and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi: 10.1161/CIRCEP.113.000334)
2012
Cheng, H., Smith, G.L. , Orchard, C.H., Hancox, J.C. and Burton, F.L. (2012) Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits. Experimental Physiology, 97(10), pp. 1131-1139. (doi: 10.1113/expphysiol.2012.065110)
Workman, A.J. , Marshall, G.E., Rankin, A.C., Smith, G.L. and Dempster, J. (2012) Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes. Journal of Physiology, 590(17), pp. 4289-4305. (doi: 10.1113/jphysiol.2012.235986)
Elliott, E.B., Kelly, A., Smith, G.L. and Loughrey, C.M. (2012) Isolated rabbit working heart function during progressive inhibition of myocardial SERCA activity. Circulation Research, 110(12), pp. 1618-1627. (doi: 10.1161/CIRCRESAHA.111.262337)
Kemi, O. J. , MacQuaide, N. , Hoydal, M. A., Ellingsen, O., Smith, G. L. and Wisloff, U. (2012) Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats. Journal of Cellular Physiology, 227(1), pp. 20-26. (doi: 10.1002/jcp.22771)
Kelly, A., Elliott, E.B., Matsuda, R., Kaneko, N., Smith, G.L. and Loughrey, C.M. (2012) The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically-induced Ca2+ overload. British Journal of Pharmacology, 165(4b), pp. 1068-1083. (doi: 10.1111/j.1476-5381.2011.01531.x)
2011
Chikando, A.C., Kettlewell, S., Williams, G.S., Smith, G.L. and Lederer, W.J. (2011) Ca2+ dynamics in the mitochondria - state of the art. Journal of Molecular and Cellular Cardiology, 51(5), pp. 627-631. (doi: 10.1016/j.yjmcc.2011.08.003) (PMID:21864537) (PMCID:PMC3814218)
Koch, L. G. et al. (2011) Intrinsic aerobic capacity sets a divide for aging and longevity. Circulation Research, 109(10), pp. 1162-1172. (doi: 10.1161/CIRCRESAHA.111.253807)
Kemi, O. J. , Hoydal, M. A., MacQuaide, N. , Haram, P. M., Koch, L. G., Britton, S. L., Ellingsen, O., Smith, G. L. and Wisloff, U. (2011) The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts. Journal of Cellular Physiology, 226(9), pp. 2235-2243. (doi: 10.1002/jcp.22559)
Stangherlin, A. et al. (2011) cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes. Circulation Research, 108(8), pp. 929-939. (doi: 10.1161/CIRCRESAHA.110.230698)
Myles, R. , Burton, F.L., Cobbe, S. and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi: 10.1016/j.yjmcc.2010.11.019)
Benson, A. P. et al. (2011) Construction and validation of anisotropic and orthotropic ventricular geometries for quantitative predictive cardiac electrophysiology. Interface Focus, 1(1), pp. 101-116. (doi: 10.1098/rsfs.2010.0005) (PMID:22419977) (PMCID:PMC3262240)
Currie, S., Elliott, E.B., Smith, G.L. and Loughrey, C.M. (2011) Two candidates at the heart of dysfunction: The ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention—An in vivo perspective. Pharmacology and Therapeutics, 131(2), pp. 204-220. (doi: 10.1016/j.pharmthera.2011.02.006)
Elliott, E.B., Hasumi, H., Otani, N., Matsuda, T., Matsuda, R., Kaneko, N., Smith, G.L. and Loughrey, C.M. (2011) K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca2+ release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes. Basic Research in Cardiology, 106(6), pp. 1009-1022. (doi: 10.1007/s00395-011-0218-4)
McMurray, J.J.V. and Smith, G.L. (2011) Calcium handling in the failing heart and SUMO — weighing the eviden. New England Journal of Medicine, (doi: 10.1056/NEJMcibr1110758)
Rota, M., Biesmans, L., MacQuaide, N. , Heinzel, F.R., Bito, V., Smith, G.L. and Sipido, K.R. (2011) Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density. PLoS ONE, 6(10), e25100. (doi: 10.1371/journal.pone.0025100)
Workman, A.J. , Smith, G.L. and Rankin, A.C. (2011) Mechanisms of termination and prevention of atrial fibrillation by drug therapy. Pharmacology and Therapeutics, 131(2), pp. 221-241. (doi: 10.1016/j.pharmthera.2011.02.002)
2010
Toischer, K. et al. (2010) K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Research in Cardiology, 105(2), pp. 279-287. (doi: 10.1007/s00395-009-0057-8)
Craig, M. A., McBride, M. W. , Smith, G., George, S. and Baker, A. (2010) Dysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat. Journal of Molecular and Cellular Cardiology, 48(6), pp. 1121-1128. (doi: 10.1016/j.yjmcc.2010.01.017)
Klauke, N., Smith, G. and Cooper, J.M. (2010) Regional electroporation of single cardiac myocytes in a focused electric field. Analytical Chemistry, 82(2), pp. 585-592. (doi: 10.1021/ac901886j)
Miller, D. J. and Smith, G. L. (2010) Lüttgau & Niedergerke; the classic study of calcium-sodium antagonism half a century on. Journal of Physiology, 588(1), pp. 23-25. (doi: 10.1113/jphysiol.2009.184242) (PMID:20045904)
Cheng, W., Klauke, N., Smith, G. and Cooper, J.M. (2010) Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes. Electrophoresis, 31(8), pp. 1405-1413.
Eisner, D. A., George, C. H., Smith, G.L. , Trafford, A. W. and Venetucci, L. A. (2010) How does CaMKII phosphorylation of the cardiac ryanodine receptor contribute to inotropy? Proceedings of the National Academy of Sciences of the United States of America, 107(31), E123-E123. (doi: 10.1073/pnas.1008809107)
MacQuaide, N. , Ramay, H.R., Sobie, E.A. and Smith, G.L. (2010) Differential sensitivity of Ca2+ wave and Ca2+ spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes. Journal of Physiology, 588(23), pp. 4731-4742. (doi: 10.1113/jphysiol.2010.193375)
Myles, R.C. , Bernus, O., Burton, F.L., Cobbe, S.M. and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi: 10.1152/ajpheart.00518.2010)
Smith, G. , Reynolds, M., Burton, F.L. and Kemi, O.J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. Methods in Cell Biology, 99(10), pp. 255-261. (doi: 10.1016/B978-0-12-374841-6.00009-8)
Smith, G. , Reynolds, M., Burton, F. and Kemi, O. J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. In: Whitaker, M. (ed.) Calcium in Living Cells. Series: Methods in cell biology (99). Elsevier, pp. 225-261. ISBN 9780123748416 (doi: 10.1016/B978-0-12-374841-6.00009-8)
Zamparelli, C., MacQuaide, N. , Colotti, G., Verzili, D., Seidler, T., Smith, G. L. and Chiancone, E. (2010) Activation of the cardiac Na+–Ca2+ exchanger by sorcin via the interaction of the respective Ca2+-binding domains. Journal of Molecular and Cellular Cardiology, 49(1), pp. 132-141. (doi: 10.1016/j.yjmcc.2010.03.003) (PMID:20298697) (PMCID:PMC2958309)
2009
Fowler, M. and Smith, G.L. (2009) The cardiac contraction cycle: is Ca2+ going local? Journal of Applied Physiology, 107(6), pp. 1981-1984. (doi: 10.1152/japplphysiol.91168.2009)
Kettlewell, S., Seidler, T. and Smith, G.L. (2009) The effects of over-expression of the FK506-binding protein FKBP12.6 on K+ currents in adult rabbit ventricular myocytes. Pflügers Archiv - European Journal of Physiology, 458(4), pp. 653-660. (doi: 10.1007/s00424-009-0666-y)
Kettlewell, S., Cabrero, P., Nicklin, S.A. , Dow, J.A.T., Davies, S.A. and Smith, G.L. (2009) Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria. Journal of Molecular and Cellular Cardiology, 46(6), pp. 891-901. (doi: 10.1016/j.yjmcc.2009.02.016) (PMID:19249308)
MacQuaide, N. , Dempster, J. and Smith, G. L. (2009) Assessment of sarcoplasmic reticulum Ca2+ depletion during spontaneous Ca2+ waves in isolated permeabilized rabbit ventricular cardiomyocytes. Biophysical Journal, 96(7), pp. 2744-2754. (doi: 10.1016/j.bpj.2008.12.3944) (PMID:19348757) (PMCID:PMC2711300)
Fowler, M. R., Colotti, G., Chiancone, E., Higuchi, Y., Seidler, T. and Smith, G. L. (2009) Complex modulation of L-type Ca2+ current inactivation by sorcin in isolated rabbit cardiomyocytes. Pflügers Archiv - European Journal of Physiology, 457(5), pp. 1049-1060. (doi: 10.1007/s00424-008-0575-5)
Fowler, M.R. and Smith, G.L. (2009) Last word on viewpoint: the cardiac contraction cycle: is Ca2+ going local? Journal of Applied Physiology, 107(6), p. 1988. (doi: 10.1152/japplphysiol.01088.2009)
Kemi, O. , MacQuaide, N. , Hoydal, M.A., Haram, P.M., Ellingsen, O., Wisloff, U. and Smith, G. (2009) Exercise training reduces spontaneous Ca2+ waves in cardiomyocytes from post-myocardial infarction heart failure rats. Biophysical Journal, 96(3.S1), 274A-275A. (doi: 10.1016/j.bpj.2008.12.1359)
Klauke, N., Smith, G.L. and Cooper, J.M. (2009) Local regional stimulation of single isolated ventricular myocytes using microfluidics. Analytical Chemistry, 81(15), pp. 6390-6398. (doi: 10.1021/ac9008429)
Masson, R. et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53(4), pp. 694-700. (doi: 10.1161/HYPERTENSIONAHA.108.122333)
Stølen, T.O. et al. (2009) Interval training normalizes cCardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. Circulation Research, 105(6), pp. 527-536. (doi: 10.1161/CIRCRESAHA.109.199810)
2008
Smith, G. and MacQuaide, N. (2008) Cytoplasmic versus intra-SR: the battle of the Ca2+ diffusion coefficients in cardiac muscle. Biophysical Journal, 95(3), pp. 1005-1006. (doi: 10.1529/biophysj.108.133926) (PMID:18469088) (PMCID:PMC2479579)
Kemi, O.J., Ellingsen, O., Smith, G.L. and Wisloff, U. (2008) Exercise-induced changes in calcium handling in left ventricular cardiomyocytes. Frontiers in Bioscience, 13, pp. 356-368. (doi: 10.2741/2685)
Fowler, M.R., Colotti, G., Chiancone, E., Smith, G.L. and Fearon, I.M. (2008) Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the alpha(1C) subunit in rabbits. Experimental Physiology, 93(12), pp. 1233-1238. (doi: 10.1113/expphysiol.2008.043497)
Kemi, O.J., Ceci, M., Condorelli, G., Smith, G.L. and Wisloff, U. (2008) Myocardial sarcoplasmic reticulurn Ca2+ ATPase function is increased by aerobic interval training. European Journal of Cardiovascular Prevention and Rehabilitation, 15(2), pp. 145-148. (doi: 10.1097/HJR.0b013e3282efd4e0)
Kemi, O.J., Ceci, M., Wisloff, U., Grimaldi, S., Gallo, P., Smith, G.L., Condorelli, G. and Ellingsen, O. (2008) Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy. Journal of Cellular Physiology, 214(2), pp. 316-321. (doi: 10.1002/jcp.21197)
Myles, R.C. , Burton, F.L., Cobbe, S.M. and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi: 10.1016/j.yjmcc.2008.03.024)
Schjerve, I. E. et al. (2008) Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults. Clinical Science, 115(9), pp. 283-293. (doi: 10.1042/CS20070332)
2007
MacQuaide, N. , Dempster, J. and Smith, G.L. (2007) Measurement and modeling of Ca2+ waves in isolated rabbit ventricular cardiomyocytes. Biophysical Journal, 93(7), pp. 2581-2595. (doi: 10.1529/biophysj.106.102293) (PMID:17545234) (PMCID:PMC1965444)
Chilton, L., Giles, W.R. and Smith, G.L. (2007) Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts. Journal of Physiology, 583(1), pp. 225-236. (doi: 10.1113/jphysiol.2007.135038)
Klauke, N., Smith, G. and Cooper, J. M. (2007) Microfluidic systems to examine intercellular coupling of pairs of cardiac myocytes. Lab on a Chip, 7, pp. 731-739. (doi: 10.1039/b706175g)
Volkers, M. et al. (2007) S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium, 41(2), pp. 135-143. (doi: 10.1016/j.ceca.2006.06.001) (PMID:16919727)
Caldwell, J., Burton, F., Smith, G. and Cobbe, S. (2007) Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 18(8), pp. 854-861. (doi: 10.1111/j.1540-8167.2007.00867.x)
Hoydal, M., Wisloff, U., Kemi, O., Britton, S., Koch, L., Smith, G. and Ellingsen, O. (2007) Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity. European Journal of Cardiovascular Prevention and Rehabilitation, 14(2), pp. 319-325.
Kemi, O., Ellingsen, O., Ceci, M., Grimaldi, S., Smith, G., Condorelli, G. and Wisloff, U. (2007) Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban. Journal of Molecular and Cellular Cardiology, 43(3), pp. 354-361. (doi: 10.1016/j.yjmcc.2007.06.013)
Loughrey, C., Otani, N., Seidler, T., Craig, M., Matsuda, R., Kaneko, N. and Smith, G. (2007) K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes. Cardiovascular Research, 76(2), pp. 236-246. (doi: 10.1016/j.cardiores.2007.06.014)
Schillinger, W. et al. (2007) Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits - Evaluation of mechanisms. Circulation, 116(1), pp. 57-66. (doi: 10.1161/CIRCULATIONAHA.106.666008)
Seidler, T., Loughrey, C., Zibrova, D., Kettlewell, S., Teucher, N., Kogler, H., Hasenfuss, G. and Smith, G. (2007) Overexpression of FK-506-binding protein 12.0 modulates excitation-contraction coupling in adult rabbit ventricular cardiomyocytes. Circulation Research, 101(10), pp. 1020-1029. (doi: 10.1161/CIRCRESAHA.107.154609)
Smith, G. (2007) Matters of the heart: the physiology of cardiac function and failure. Experimental Physiology, 92(6), pp. 973-986. (doi: 10.1113/expphysiol.2007.034314)
Walker, N., Burton, F., Kettlewell, S., Smith, G. and Cobbe, S. (2007) Mapping of epicardial activation in a rabbit model of chronic myocardial infarction: Response to atrial, endocardial, and epicardial pacing. Journal of Cardiovascular Electrophysiology, 18(8), pp. 862-868. (doi: 10.1111/j.1540-8167.2007.00858.x)
Wisloff, U. et al. (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients - A randomized study. Circulation, 115(24), pp. 3086-3094. (doi: 10.1161/CIRCULATIONAHA.106.675041)
2006
Cheng, W., Klauke, N., Sedgwick, H., Smith, G. L. and Cooper, J. M. (2006) Metabolic monitoring of the electrically stimulated single heart cell within a microfluidic platform. Lab on a Chip, 6(11), pp. 1424-1431. (doi: 10.1039/b608202e)
Smith, G. and MacQuaide, N. (2006) Swallowing a spider to catch a fly: ca-calmodulin dynamics in adult cardiomyocytes. Journal of Molecular and Cellular Cardiology, 41(3), pp. 416-417. (doi: 10.1016/j.yjmcc.2006.06.008) (PMID:16870208)
Colotti, G., Zamparelli, C., Verzili, D., Mella, M., Loughrey, C., Smith, G. and Chiancone, E. (2006) The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca2+-dependent interaction with annexin VII and the cardiac ryanodine receptor. Biochemistry, 45(41), pp. 12519-12529. (doi: 10.1021/bi060416a)
Kemi, O., Arbo, I., Hoydal, M., Loennechen, J., Wisloff, U., Smith, G. and Ellingsen, O. (2006) Reduced pH and contractility in failing rat cardiomyocytes. Acta Physiologica, 188(3-4), pp. 185-193. (doi: 10.1111/j.1748-1716.2006.01621.x)
Smith, G.L., Elliott, E.B., Kettlewell, S., Currie, S. and Quinn, F.R. (2006) Na+/Ca2+ Exchanger Expression and Function in a Rabbit Model of Myocardial Infarction. Journal of Cardiovascular Electrophysiology, 17(s1), S57-S63. (doi: 10.1111/j.1540-8167.2006.00384.x)
2005
Currie, S., Quinn, F., Sayeed, R., Duncan, A., Kettlewell, S. and Smith, G. (2005) Selective down-regulation of sub-endocardial ryanodine receptor expression in a rabbit model of left ventricular dysfunction. Journal of Molecular and Cellular Cardiology, 39(2), pp. 309-317. (doi: 10.1016/j.yjmcc.2005.04.005)
Kettlewell, S., Most, P., Currie, S., Koch, W. and Smith, G. (2005) S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes. Journal of Molecular and Cellular Cardiology, 39(6), pp. 900-910. (doi: 10.1016/j.yjmcc.2005.06.018)
Kohl, P., Camelliti, P., Burton, F. and Smith, G. (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of Electrocardiology, 38(4), pp. 45-50. (doi: 10.1016/j.jelectrocard.2005.06.096)
Miller, S., Currie, S., Loughrey, C., Kettlewell, S., Seidler, T., Reynolds, D., Hasenfuss, G. and Smith, G. (2005) Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Cardiovascular Research, 67(4), pp. 667-677. (doi: 10.1016/j.cardiores.2005.04.023)
2004
MacEachern, K.E. , Smith, G.L. and Nolan, A.M. (2004) Characteristics of the in vitro hypoxic pulmonary vasoconstrictor response in isolated equine and bovine pulmonary arterial rings. Veterinary Anaesthesia and Analgesia, 31(4), pp. 239-249. (doi: 10.1111/j.1467-2995.2004.00176.x) (PMID:15509288)
Loughrey, C.M. , Smith, G.L. and MacEachern, K.E. (2004) Comparison of Ca2+ release and uptake characteristics of the sarcoplasmic reticulum in isolated horse and rabbit cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 287(3), H1149-H1159. (doi: 10.1152/ajpheart.00060.2004) (PMID:15117716)
Loughrey, C.M. , Seidler, T., Miller, S.L.W., Prestle, J., MacEachern, K.E. , Reynolds, D.F., Hasenfuss, G. and Smith, G.L. (2004) Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes. Journal of Physiology, 556(3), pp. 919-934. (doi: 10.1113/jphysiol.2003.057166)
Currie, S., Loughrey, C., Craig, M. and Smith, G. (2004) Calcium/calmodulin-dependent protein kinase II delta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochemical Journal, 377(2), pp. 357-366. (doi: 10.1042/BJ200310431)
Kettlewell, S., Walker, N., Cobbe, S., Burton, F. and Smith, G. (2004) The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Experimental Physiology, 89(2), pp. 163-172. (doi: 10.1113/expphysiol.2003.026732)
Teucher, N. et al. (2004) Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening. Circulation, 110(23), pp. 3553-3559. (doi: 10.1161/01.CIR.0000145161.48545.B3)
Wokosin, D., Loughrey, C. and Smith, G. (2004) Characterization of a range of fura dyes with two-photon excitation. Biophysical Journal, 86(3), pp. 1726-1738. (doi: 10.1016/S0006-3495(04)74241-1)
2003
Quinn, F.R., Currie, S., Duncan, A.M., Miller, S., Sayeed, R., Cobbe, S.M. and Smith, G.L. (2003) Myocardial infarction causes increased expression but decreased activity of the myocardial Na+-Ca2+ exchanger in the rabbit. Journal of Physiology, 553(1), pp. 229-242. (doi: 10.1113/jphysiol.2003.050716)
Loughrey, C.M. , MacEachern, K.E. , Cooper, J. and Smith, G.L. (2003) Measurement of the dissociation constant of Fluo-3 for Ca2+ in isolated rabbit cardiomyocytes using Ca2+ wave characteristics. Cell Calcium, 34(1), pp. 1-9. (doi: 10.1016/S0143-4160(03)00012-5) (PMID:12767887)
McConnell, G., Smith, G., Girkin, J., Gurney, A. and Ferguson, A. (2003) Two-photon microscopy of fura-2-loaded cardiac myocytes with an all-solid-state tunable and visible femtosecond laser source. Optics Letters, 28(19), pp. 1742-1744. (doi: 10.1364/OL.28.001742)
Most, P. et al. (2003) The C terminus (amino acids 75-94) and the linker region (amino acids 42-54) of the Ca2+-binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibers. Journal of Biological Chemistry, 278(29), pp. 26356-26364. (doi: 10.1074/jbc.M303338200)
Prestle, J., Quinn, F. and Smith, G. (2003) Ca2+-handling proteins and heart failure: Novel molecular targets? Current Medicinal Chemistry, 10(11), pp. 967-981.
Seidler, T. et al. (2003) Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Circulation Research, 93(2), pp. 132-139. (doi: 10.1161/01.RES.0000081596.90205.E2)
Zhang, H. et al. (2003) Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. International Journal of Bifurcation and Chaos, 13(12), pp. 3535-3560. (doi: 10.1142/S0218127403008843)
2002
Loughrey, C.M. , MacEachern, K.E. , Neary, P. and Smith, G.L. (2002) The relationship between intracellular [Ca2+] and Ca2+ wave characteristics in permeabilised cardiomyocytes from the rabbit. Journal of Physiology, 543(3), pp. 859-870. (doi: 10.1113/jphysiol.2002.021519) (PMID:12231644)
Neary, P., Duncan, A.M., Cobbe, S.M. and Smith, G.L. (2002) Assessment of sarcoplasmic reticulum Ca2+ flux pathways in cardiomyocytes from rabbits with infarct-induced left-ventricular dysfunction. Pflügers Archiv - European Journal of Physiology, 444(3), pp. 360-371. (doi: 10.1007/s00424-002-0794-0)
Ng, G.A., Hicks, M.N., Cobbe, S.M. and Smith, G.L. (2002) Depressed inotropic response to increased preload in rabbit hearts with left-ventricular dysfunction induced by chronic myocardial infarction. Pflügers Archiv - European Journal of Physiology, 444(4), pp. 513-522. (doi: 10.1007/s00424-002-0848-3)
Cai, X., Klauke, N., Glidle, A., Cobbold, P., Smith, G.L. and Cooper, J.M. (2002) Ultra-low-volume, real-time measurements of lactate from the single heart cell using microsystems technology. Analytical Chemistry, 74(4), pp. 908-914. (doi: 10.1021/ac010941+)
Wisloff, U., Loennechen, J., Currie, S., Smith, G. and Ellingsen, O. (2002) Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction. Cardiovascular Research, 54(1), pp. 162-174. (doi: 10.1016/S0008-6363(01)00565-X)
2001
Smith, G.L. and ONeill, S.C. (2001) A comparison of the effects of ATP and tetracaine on spontaneous Ca2+ release from rat permeabilised cardiac myocytes. Journal of Physiology, 534(1), pp. 37-47. (doi: 10.1111/j.1469-7793.2001.00037.x)
Most, P. et al. (2001) S100A1: A regulator of myocardial contractility. Proceedings of the National Academy of Sciences of the United States of America, 98(24), pp. 13889-13894. (doi: 10.1073/pnas.241393598)
Prestle, J., Janssen, P., Janssen, A., Zeitz, O., Lehnart, S., Bruce, L., Smith, G. and Hasenfuss, G. (2001) Overexpression of FK506-Binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca2+ leak from the sarcoplasmic reticulum and increases contractility. Circulation Research, 88(2), pp. 188-194.
Wisloff, U., Loennechen, J., Falck, G., Beisvag, V., Currie, S., Smith, G. and Ellingsen, O. (2001) Increased contractility and calcium sensitivity in cardiac myocytes isolated from endurance trained rats. Cardiovascular Research, 50(3), pp. 495-508. (doi: 10.1016/S0008-6363(01)00210-3)
1997
MacEachern, K.E. , Smith, G. and Nolan, A.M. (1997) The Role of Endothelins in Equine Pulmonary Arteries in Vitro. Journal of Veterinary Pharmacology and Therapeutics 20(Suppl 1): S246. 7th European Association for Veterinary Pharmacology and Toxicology (EAVPT) International Congress, Madrid, Spain, 06-10 Jul 1997.
MacEachern, K.E. , Smith, G.L. and Nolan, A.M. (1997) Methods for the isolation, culture and characterisation of equine pulmonary artery endothelial cells. Research in Veterinary Science, 62(2), pp. 147-152. (doi: 10.1016/S0034-5288(97)90137-5) (PMID:9243714)
1996
MacEachern, K.E. , Smith, G.L. and Nolan, A.M. (1996) Characterisation of Equine Vascular Endothelial Cells in vitro. Association of Veterinary Teachers and Research Workers Jubilee Meeting, Scarborough, UK, 02-04 Apr 1996.
1995
MacEachern, K.E. , Smith, G.L. and Nolan, A.M. (1995) Investigation of the Hypoxic Pulmonary Vasoconstrictor Response in Horse Tissue. British Equine Veterinary Congress, Harrogate, UK, 1995.
1994
MacFarlane, N.G., Miller, D.J., Smith, G.L. and Steele, D.S. (1994) Effects of oxidants on the sarcoplasmic reticulum of saponin treated rat ventricular trabeculae. Cardiovascular Research, 28(11), pp. 1647-1652. (doi: 10.1093/cvr/28.11.1647) (PMID:7842458)
Articles
Kemi, O. J. , Hoydal, M. A., Haram, P. M., Smith, G. L. , Ellingsen, O., Koch, L. G., Britton, S. L. and Wisloff, U. (2024) Inherited physical capacity: Widening divergence from young to adult to old. Annals of the New York Academy of Sciences, (doi: 10.1111/nyas.15130) (PMID:38520387) (Early Online Publication)
Loughrey, C. et al. (2024) A novel ryanodine receptor 2 inhibitor, M201-A, enhances natriuresis, renal function and lusi-inotropic action: Pre-clinical and phase I study. British Journal of Pharmacology, (Accepted for Publication)
Freeman, M., Huethorst, E. , Boland, E., Dunne, M., Burton, F., Denning, C., Myles, R. and Smith, G. (2024) A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit. American Journal of Physiology: Heart and Circulatory Physiology, (doi: 10.1152/ajpheart.00657.2023) (PMID:38180449) (Early Online Publication)
Da Silva Costa, A. et al. (2023) Electrically stimulated in vitro heart cell mimic of acute exercise reveals novel immediate cellular responses to exercise: Reduced contractility and metabolism, but maintained calcium cycling and increased myofilament calcium sensitivity. Cell Biochemistry and Function, 41(8), pp. 1147-1161. (doi: 10.1002/cbf.3847) (PMID:37665041)
Selli, A. L., Ghasemi, M., Watters, T., Burton, F., Smith, G. and Dietrichs, E. S. (2023) Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 31(1), 61. (doi: 10.1186/s13049-023-01134-5) (PMID:37880801) (PMCID:PMC10601188)
Eisner, D., Neher, E., Taschenberger, H. and Smith, G. (2023) Physiology of intracellular calcium buffering. Physiological Reviews, 103(4), pp. 2767-2845. (doi: 10.1152/physrev.00042.2022) (PMID:37326298)
Giommi, A., Gurgel, A. R. B., Smith, G. L. and Workman, A. J. (2023) Does the small conductance Ca2+-activated K+ current ISK flow under physiological conditions in rabbit and human atrial isolated cardiomyocytes? Journal of Molecular and Cellular Cardiology, 183, pp. 70-80. (doi: 10.1016/j.yjmcc.2023.09.002) (PMID:37704101)
Simitev, R. D. , Al dawoud, A., Aziz, M. H.N., Myles, R. and Smith, G. L. (2023) Phenomenological analysis of simple ion channel block in large populations of uncoupled cardiomyocytes. Mathematical Medicine and Biology, 40(2), pp. 175-198. (doi: 10.1093/imammb/dqad001) (PMID:36689769)
Lu, H. R., Van de Sande, D., Mohammadreza, G., Watters, T., Burton, F., Pham, L., Altrocchi, C., Gallacher, D. J. and Smith, G. (2023) Are more mature hiPSC-cardiomyocytes better for the detection of drug-induced cardiotoxicity? Biomolecules, 13(4), 676. (doi: 10.3390/biom13040676) (PMID:37189424) (PMCID:PMC10135569)
Kuo, C.-W. S. et al. (2023) Palmitoylation of the pore-forming subunit of Ca(v)1.2 controls channel voltage sensitivity and calcium transients in cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America, 120(7), e220788712. (doi: 10.1073/pnas.2207887120) (PMID:36745790) (PMCID:PMC9963536)
Alexander, C., Bishop, M. J., Gilchrist, R. J., Burton, F. L., Smith, G. L. and Myles, R. C. (2023) Initiation of ventricular arrhythmia in the acquired long QT syndrome. Cardiovascular Research, 119(2), pp. 465-476. (doi: 10.1093/cvr/cvac103) (PMID:35727943) (PMCID:PMC10064840)
Saxena, P., Myles, R. C. , Smith, G. L. and Workman, A. J. (2022) Adrenoceptor sub-type involvement in Ca2+ current stimulation by noradrenaline in human and rabbit atrial myocytes. Pflügers Archiv European Journal of Physiology, 474(12), pp. 1311-1321. (doi: 10.1007/s00424-022-02746-z) (PMID:36131146) (PMCID:PMC9663393)
Lachaud, Q., Aziz, M. H. N., Burton, F. L., Macquaide, N. , Myles, R. C. , Simitev, R. D. and Smith, G. L. (2022) Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes. Cardiovascular Research, 118(15), pp. 3112-3125. (doi: 10.1093/cvr/cvab375) (PMID:35020837) (PMCID:PMC9732512)
Bruegmann, T., Smith, G. L. and Lehnart, S. E. (2022) Editorial: Cardiac optogenetics: Using light to observe and excite the heart. Frontiers in Physiology, 13, 1031062. (doi: 10.3389/fphys.2022.1031062) (PMID:36304575) (PMCID:PMC9593031)
Main, A. et al. (2022) Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies. Frontiers in Physiology, 13, 1023237. (doi: 10.3389/fphys.2022.1023237) (PMID:36277202) (PMCID:PMC9581287)
Fertig, B. et al. (2022) SUMOylation does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca2+. FEBS Journal, 289(20), pp. 6267-6285. (doi: 10.1111/febs.16537) (PMID:35633070) (PMCID:PMC9588612)
Malagueta-Vieira, L. et al. (2022) Metformin reduces potassium currents and prolongs repolarization in non-diabetic heart. International Journal of Molecular Sciences, 23(11), 6021. (doi: 10.3390/ijms23116021) (PMID:35682699) (PMCID:PMC9181026)
He, W. et al. (2022) Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size. Cardiovascular Research, 118(6), pp. 1535-1547. (doi: 10.1093/cvr/cvab204) (PMID:34132807)
Tibbo, A. J. et al. (2022) Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins. Journal of Molecular and Cellular Cardiology, 165, pp. 86-102. (doi: 10.1016/j.yjmcc.2022.01.001) (PMID:34999055) (PMCID:PMC8986152)
Dietrichs, E. S. and Smith, G. L. (2022) Prediction of ventricular arrhythmias by QRS/QTc - ratio in Citalopram or Escitalopram intoxication. Frontiers in Medicine, 9, 866454. (doi: 10.3389/fmed.2022.866454) (PMID:35372426) (PMCID:PMC8966227)
Huethorst, E. , Mortensen, P., Simitev, R. D. , Gao, H. , Pohjolainen, L., Talman, V., Ruskoaho, H., Burton, F. L., Gadegaard, N. and Smith, G. L. (2022) Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell derived cardiomyocytes. Journal of Physiology, 600(3), pp. 483-507. (doi: 10.1113/JP282228) (PMID:34761809) (PMCID:PMC9299844)
Faulkner-Jones, A., Zamora, V., Hortigon-Vinagre, M. P., Wang, W., Ardron, M., Smith, G. L. and Shu, W. (2022) A bioprinted heart-on-a-chip with human pluripotent stem cell-derived cardiomyocytes for drug evaluation. Bioengineering, 9(1), 32. (doi: 10.3390/bioengineering9010032) (PMID:35049741) (PMCID:PMC8773426)
Müllenbroich, M. C. et al. (2021) Novel optics-based approaches for cardiac electrophysiology: a review. Frontiers in Physiology, 12, 769586. (doi: 10.3389/fphys.2021.769586) (PMID:34867476) (PMCID:PMC8637189)
Sveberg Dietrichs, E., Myles, R. and Smith, G. (2021) Is hypothermia more neuroprotective than avoiding fever after cardiac arrest? Cardiovascular Research, 117(12), e159-e161. (doi: 10.1093/cvr/cvab297) (PMID:34718465) (PMCID:PMC8562327)
Jabbour, R. J. et al. (2021) In vivo grafting of large engineered heart tissue patches for cardiac repair. JCI Insight, 6(15), e144068. (doi: 10.1172/jci.insight.144068) (PMID:34369384) (PMCID:PMC8410032)
Holmes, A. P. et al. (2021) The atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone. Heart Rhythm, 18(7), pp. 1212-1220. (doi: 10.1016/j.hrthm.2021.03.016) (PMID:33737232)
Bowman, P. R.T., Smith, G. L. and Gould, G. W. (2021) Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease? PeerJ, 9, e11485. (doi: 10.7717/peerj.11485) (PMID:34113491) (PMCID:PMC8162245)
Hortigon-Vinagre, M.P., Zamora, V., Burton, F. L. and Smith, G. L. (2021) The use of voltage sensitive dye di-4-ANEPPS and video-based contractility measurements to assess drug effects on excitation-contraction coupling in human induced pluripotent stem cell-derived cardiomyocytes. Journal of Cardiovascular Pharmacology, 77(3), pp. 280-290. (doi: 10.1097/FJC.0000000000000937) (PMID:33109927)
Mortensen, P., Gao, H. , Smith, G. and Simitev, R. D. (2021) Action potential propagation and block in a model of atrial tissue with myocyte-fibroblast coupling. Mathematical Medicine and Biology, 38(1), pp. 106-131. (doi: 10.1093/imammb/dqaa014) (PMID:33412587)
Da Silva Costa, A. , Mortensen, P., Hortigon-Vinagre, M. P., van der Heyden, M. A. G., Burton, F. L., Gao, H. , Simitev, R. D. and Smith, G. L. (2021) Electrophysiology of hiPSC-cardiomyocytes co-cultured with HEK cells expressing the inward rectifier channel. International Journal of Molecular Sciences, 22(12), 6621. (doi: 10.3390/ijms22126621)
Mortensen, P., Gao, H. , Smith, G. and Simitev, R. D. (2021) Addendum: Action potential propagation and block in a model of atrial tissue with myocyte-fibroblast coupling. Mathematical Medicine and Biology, 38(3), pp. 292-298. (doi: 10.1093/imammb/dqab005) (PMID:33959762)
Dietrichs, E. S., McGlynn, K., Allan, A., Connolly, A., Bishop, M., Burton, F., Kettlewell, S., Myles, R. , Tveita, T. and Smith, G. L. (2020) Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology. Cardiovascular Research, 116(13), pp. 2081-2090. (doi: 10.1093/cvr/cvz309) (PMID:32031595) (PMCID:PMC7584464)
Salerno, S., Solvang-Garten, K., Smith, G. L. , Stølen, T. and Kelly, A. (2020) Two-photon excitation of FluoVolt allows improved interrogation of transmural electrophysiological function in the intact mouse heart. Progress in Biophysics and Molecular Biology, 154, pp. 11-20. (doi: 10.1016/j.pbiomolbio.2019.08.007) (PMID:31492464) (PMCID:PMC7322535)
Błyszczuk, P., Zuppinger, C., Costa, A. , Nurzynska, D., Di Meglio, F., Stellato, M., Agarkova, I., Smith, G. , Distler, O. and Kania, G. (2020) Activated cardiac fibroblasts control contraction of human fibrotic cardiac microtissues by a β-adrenoreceptor-dependent mechanism. Cells, 9(5), 1270. (doi: 10.3390/cells9051270) (PMID:32443848) (PMCID:PMC7290967)
Dietrichs, E. S., Tveita, T., Myles, R. and Smith, G. (2020) A novel ECG-biomarker for cardiac arrest during hypothermia. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 28, 27. (doi: 10.1186/s13049-020-00721-0) (PMID:32276599) (PMCID:PMC7149849)
de Korte, T. et al. (2020) Unlocking personalized biomedicine and drug discovery with human induced pluripotent stem cell–derived cardiomyocytes: fit for purpose or forever elusive? Annual Review of Pharmacology and Toxicology, 60(1), pp. 529-551. (doi: 10.1146/annurev-pharmtox-010919-023309) (PMID:31506008)
Li, Z. et al. (2020) General principles for the validation of proarrhythmia risk prediction models: an extension of the CiPA In Silico Strategy. Clinical Pharmacology and Therapeutics, 107(1), pp. 102-111. (doi: 10.1002/cpt.1647) (PMID:31709525) (PMCID:PMC6977398)
McArthur, L. , Riddell, A. , Chilton, L., Smith, G. L. and Nicklin, S. A. (2020) Regulation of connexin 43 by interleukin 1β in adult rat cardiac fibroblasts and effects in an adult rat cardiac myocyte: fibroblast co-culture model. Heliyon, 6(1), e03031. (doi: 10.1016/j.heliyon.2019.e03031) (PMID:31909243) (PMCID:PMC6940628)
Gould, G. , Bowman, P. and Smith, G. (2019) Cardiac SNARE expression in health and disease. Frontiers in Endocrinology, 10, 881. (doi: 10.3389/fendo.2019.00881) (PMID:31920989) (PMCID:PMC6930865)
Bowman, P. R.T., Smith, G. L. and Gould, G. W. (2019) GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes. PLoS ONE, 14(7), e0217885. (doi: 10.1371/journal.pone.0217885) (PMID:31920989) (PMCID:PMC6930865)
Kettlewell, S., Saxena, P., Dempster, J., Colman, M. A., Myles, R. C. , Smith, G. L. and Workman, A. J. (2019) Dynamic‐clamping human and rabbit atrial calcium current: narrowing ICaL window abolishes early afterdepolarisations. Journal of Physiology, 597(14), pp. 3619-3638. (doi: 10.1113/JP277827) (PMID:31093979) (PMCID:PMC6767690)
Smith, G. L. and Eisner, D. A. (2019) Calcium buffering in the heart in health and disease. Circulation, 139(20), pp. 2358-2371. (doi: 10.1161/circulationaha.118.039329) (PMID:31082292) (PMCID:PMC6520234)
Ghouri, I. A., Kelly, A., Salerno, S., Garten, K., Stølen, T., Kemi, O.-J. and Smith, G. L. (2019) Corrigendum: Characterization of electrical activity in post-myocardial infarction scar tissue in rat hearts using multiphoton microscopy. Frontiers in Physiology, 10, 364. (doi: 10.3389/fphys.2019.00364) (PMID:31024333) (PMCID:PMC6461023)
Dietrichs, E. S., Tveita, T. and Smith, G. (2019) Hypothermia and cardiac electrophysiology: a systematic review of clinical and experimental data. Cardiovascular Research, 115(3), pp. 501-509. (doi: 10.1093/cvr/cvy305) (PMID:30544147)
Pfeiffer-Kaushik, E. R. et al. (2019) Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms. Journal of Pharmacological and Toxicological Methods, 99, 106612. (doi: 10.1016/j.vascn.2019.106612) (PMID:31319140)
Lemme, M. et al. (2018) Atrial-like engineered heart tissue: an in vitro model of the human atrium. Stem Cell Reports, 11(6), pp. 1378-1390. (doi: 10.1016/j.stemcr.2018.10.008) (PMID:30416051) (PMCID:PMC6294072)
Connolly, A., Kelly, A., Campos, F. O., Myles, R. , Smith, G. and Bishop, M. J. (2018) Ventricular endocardial tissue geometry affects stimulus threshold and effective refractory period. Biophysical Journal, 115(12), pp. 2486-2498. (doi: 10.1016/j.bpj.2018.11.003) (PMID:30503533) (PMCID:PMC6301915)
Ghouri, I. A., Kelly, A., Salerno, S., Garten, K., Stølen, T., Kemi, O.-J. and Smith, G. L. (2018) Characterization of electrical activity in post-myocardial infarction scar tissue in rat hearts using multiphoton microscopy. Frontiers in Physiology, 9, 1454. (doi: 10.3389/fphys.2018.01454) (PMID:30386255) (PMCID:PMC6199960)
van Meer, B. J., Sala, L., Tertoolen, L. G.J., Smith, G. L. , Burton, F. L. and Mummery, C. L. (2018) Quantification of muscle contraction in vitro and in vivo using MUSCLEMOTION software: from stem cell-derived cardiomyocytes to zebrafish and human hearts. Current Protocols in Human Genetics, 99(1), e67. (doi: 10.1002/cphg.67) (PMID:30253059)
Blinova, K. et al. (2018) International multisite study of human-induced pluripotent stem cell-derived cardiomyocytes for drug proarrhythmic potential assessment. Cell Reports, 24(13), pp. 3582-3592. (doi: 10.1016/j.celrep.2018.08.079) (PMID:30257217) (PMCID:PMC6226030)
Bruegmann, T. and Smith, G. L. (2018) Macrophages: new players in cardiac ageing? Cardiovascular Research, 114(7), e47-e49. (doi: 10.1093/cvr/cvy047) (PMID:29800376)
Høydal, M. A. et al. (2018) Human cardiomyocyte calcium handling and transverse tubules in mid-stage of post-myocardial-infarction heart failure. ESC Heart Failure, 5(3), pp. 332-342. (doi: 10.1002/ehf2.12271) (PMID:29431258) (PMCID:PMC5933953)
Kelly, A., Salerno, S., Connolly, A., Bishop, M., Charpentier, F., Stølen, T. and Smith, G. L. (2018) Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome. Cardiovascular Research, 114(5), pp. 724-736. (doi: 10.1093/cvr/cvx244) (PMID:29267949) (PMCID:PMC5915948)
Boyden, P. A. and Smith, G. L. (2018) Ca2+ leak, what is it? Why should we care? Can it be managed? Heart Rhythm, 15(4), pp. 607-614. (doi: 10.1016/j.hrthm.2017.11.018) (PMID:29157722)
Malmo, V., Kelly, A., Garten, K. S., Stolen, T., Rolim, N. P. L., Wisloff, U., Smith, G. and Loennechen, J. P. (2018) Aerobic interval training prevents age-dependent vulnerability to atrial fibrillation in rodents. Frontiers in Physiology, 9, 206. (doi: 10.3389/fphys.2018.00206) (PMID:29593565)
Sala, L. et al. (2018) MUSCLEMOTION: a versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo. Circulation Research, 122(3), e5-e16. (doi: 10.1161/CIRCRESAHA.117.312067) (PMID:29282212) (PMCID:PMC5805275)
McCarroll, C. S. et al. (2018) Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction. Circulation, 137(1), pp. 57-70. (doi: 10.1161/CIRCULATIONAHA.117.028911) (PMID:29030345) (PMCID:PMC5757664)
Lachaud, Q., MacQuaide, N. , Burton, F. and Smith, G. (2018) High-throughput study of rabbit ventricle action potential populations in MI model. Biophysical Journal, 114(3.S1), 625A. (doi: 10.1016/j.bpj.2017.11.3377)
Lei, C. L. et al. (2017) Tailoring mathematical models to stem-cell derived cardiomyocyte lines can improve predictions of drug-induced changes to their electrophysiology. Frontiers in Physiology, 8, 986. (doi: 10.3389/fphys.2017.00986) (PMID:29311950) (PMCID:PMC5732978)
Duncan, G., Firth, K., George, V., Hoang, M. D., Staniforth, A., Smith, G. and Denning, C. (2017) Drug-mediated shortening of action potentials in LQTS2 human induced pluripotent stem cell-derived cardiomyocytes. Stem Cells and Development, 26(23), pp. 1695-1705. (doi: 10.1089/scd.2017.0172) (PMID:28992755) (PMCID:PMC5706629)
Stevens, K., Denby, L., Patel, R. K., Mark, P. B. , Kettlewell, S., Smith, G. L. , Clancy, M. J., Delles, C. and Jardine, A. G. (2017) Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway. Nephrology Dialysis Transplantation, 32(10), pp. 1617-1627. (doi: 10.1093/ndt/gfw252) (PMID:27448672) (PMCID:PMC5837731)
Lu, H.R., Hortigon-Vinagre, M.P. , Zamora, V., Kopljar, I., De Bondt, A., Gallacher, D.J. and Smith, G. (2017) Application of optical action potentials in human induced pluripotent stem cells-derived cardiomyocytes to predict drug-induced cardiac arrhythmias. Journal of Pharmacological and Toxicological Methods, 87, pp. 53-67. (doi: 10.1016/j.vascn.2017.05.001) (PMID:28501647)
Saxena, P. et al. (2017) Correlation between human ether-a-go-go-related gene channel inhibition and action potential prolongation. British Journal of Pharmacology, 174(18), pp. 3081-3093. (doi: 10.1111/bph.13942) (PMID:28681507) (PMCID:PMC5573420)
Lamore, S. D. et al. (2017) Deconvoluting kinase inhibitor induced cardiotoxicity. Toxicological Sciences, 158(1), pp. 213-226. (doi: 10.1093/toxsci/kfx082) (PMID:28453775)
Blinova, K. et al. (2017) Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias. Toxicological Sciences, 155(1), pp. 234-247. (doi: 10.1093/toxsci/kfw200) (PMID:27701120)
Fattah, C. et al. (2016) Gene therapy with Angiotensin-(1-9) preserves left ventricular systolic function after myocardial infarction. Journal of the American College of Cardiology, 68(24), pp. 2652-2666. (doi: 10.1016/j.jacc.2016.09.946) (PMID:27978950) (PMCID:PMC5158000)
Huethorst, E., Hortigon, M. , Zamora-Rodriguez, V., Reynolds, P.M. , Burton, F., Smith, G. and Gadegaard, N. (2016) Enhanced human-induced pluripotent stem cell derived cardiomyocyte maturation using a dual microgradient substrate. ACS Biomaterials Science and Engineering, 2(12), pp. 2231-2239. (doi: 10.1021/acsbiomaterials.6b00426) (PMID:27990488) (PMCID:PMC5155309)
Hortigon-Vinagre, M.P., Zamora, V., Burton, F.L., Green, J., Gintant, G.A. and Smith, G.L. (2016) The use of ratiometric fluorescence measurements of the voltage sensitive dye Di-4-ANEPPS to examine action potential characteristics and drug effects on human induced pluripotent stem cell-derived cardiomyocytes. Toxicological Sciences, 154(2), pp. 320-331. (doi: 10.1093/toxsci/kfw171) (PMID:27621282) (PMCID:PMC5139069)
Weinberger, F. et al. (2016) Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells. Science Translational Medicine, 8(363), 363ra148-363ra148. (doi: 10.1126/scitranslmed.aaf8781) (PMID:27807283)
Crocini, C. et al. (2016) Optogenetics design of mechanistically-based stimulation patterns for cardiac defibrillation. Scientific Reports, 6, 35628. (doi: 10.1038/srep35628) (PMID:27748433) (PMCID:PMC5066272)
Høydal, M. A. et al. (2016) Exercise training reverses myocardial dysfunction induced by CaMKIIδC overexpression by restoring Ca2+-homeostasis. Journal of Applied Physiology, 121(1), pp. 212-220. (doi: 10.1152/japplphysiol.00188.2016) (PMID:27231311)
Baumert, M., Porta, A., Vos, M. A., Malik, M., Couderc, J.-P., Laguna, P., Piccirillo, G., Smith, G. L. , Tereshchenko, L. G. and Volders, P. G.A. (2016) QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology. Europace, 18(6), pp. 925-944. (doi: 10.1093/europace/euv405) (PMID:26823389) (PMCID:PMC4905605)
Nisbet, A. M., Camelliti, P., Walker, N. L., Burton, F. L., Cobbe, S. M., Kohl, P. and Smith, G. L. (2016) Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: role of fibrosis and connexin remodelling. Journal of Molecular and Cellular Cardiology, 94, pp. 54-64. (doi: 10.1016/j.yjmcc.2016.03.011) (PMID:27021518) (PMCID:PMC4873602)
Rog-Zielinska, E.A. et al. (2015) Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α. Cell Death and Differentiation, 22(7), pp. 1106-1116. (doi: 10.1038/cdd.2014.181) (PMID:25361084) (PMCID:PMC4572859)
McArthur, L. , Chilton, L., Smith, G. L. and Nicklin, S. A. (2015) Electrical consequences of cardiac myocyte: fibroblast coupling. Biochemical Society Transactions, 43(3), pp. 513-518. (doi: 10.1042/BST20150035) (PMID:26009200)
Smith, G. L. and MacQuaide, N. (2015) The direct actions of flecainide on the human cardiac ryanodine receptor: keeping open the debate on the mechanism of action of local anesthetics in CPVT. Circulation Research, 116(8), pp. 1284-1286. (doi: 10.1161/CIRCRESAHA.115.306298) (PMID:25858058)
Ghouri, I. A., Kelly, A., Burton, F. L., Smith, G. L. and Kemi, O. J. (2015) 2-photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca2+in intact mice, rat, and rabbit hearts. Journal of Biophotonics, 8(1-2), pp. 112-123. (doi: 10.1002/jbio.201300109)
Campbell, A. S., Johnstone, S. R., Baillie, G. S. and Smith, G. (2014) β-Adrenergic modulation of myocardial conduction velocity: Connexins vs. sodium current. Journal of Molecular and Cellular Cardiology, 77, pp. 147-154. (doi: 10.1016/j.yjmcc.2014.09.030)
Boyman, L., Chikando, A. C., Williams, G. S.B., Khairallah, R. J., Kettlewell, S., Ward, C. W., Smith, G. L. , Kao, J. P.Y. and Lederer, W. J. (2014) Calcium movement in cardiac mitochondria. Biophysical Journal, 107(6), pp. 1289-1301. (doi: 10.1016/j.bpj.2014.07.045)
Haviland, S., Cleemann, L., Kettlewell, S., Smith, G. L. and Morad, M. (2014) Diversity of mitochondrial Ca²⁺ signaling in rat neonatal cardiomyocytes: evidence from a genetically directed Ca²⁺ probe mitycam-E31Q. Cell Calcium, 56(3), pp. 133-146. (doi: 10.1016/j.ceca.2014.06.001) (PMID:24994483)
O-Uchi, J. et al. (2014) Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. Antioxidants and Redox Signaling, 21(6), pp. 863-879. (doi: 10.1089/ars.2013.5394)
Liu, T., Takimoto, E., Dimaano, V. L., DeMazumder, D., Kettlewell, S., Smith, G. , Sidor, A., Abraham, T. P. and O'Rourke, B. (2014) Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a guinea pig model of heart failure. Circulation Research, 115(1), pp. 44-54. (doi: 10.1161/CIRCRESAHA.115.303062) (PMID:24780171) (PMCID:PMC4219273)
Høydal, M.A., Stølen, T.O., Johnsen, A.B., Alvez, M., Catalucci, D., Condorelli, G., Koch, L.G., Britton, S.L., Smith, G.L. and Wisløff, U. (2014) Reduced aerobic capacity causes leaky ryanodine receptors that trigger arrhythmia in a rat strain artificially selected and bred for low aerobic running capacity. Acta Physiologica, 210(4), pp. 854-864. (doi: 10.1111/apha.12238)
Hohendanner, F., Walther, S., Maxwell, J. T., Kettlewell, S., Awad, S., Smith, G. , Lonchyna, V. A. and Blatter, L. A. (2014) Inositol-1,4,5-trisphosphate induced Ca2+release and excitation-contraction coupling in atrial myocytes from normal and failing hearts. Journal of Physiology, 593(6), pp. 1459-1477. (doi: 10.1113/jphysiol.2014.283226) (PMID:25416623)
Nisbet, A. M., Burton, F. L., Walker, N. L., Craig, M. A., Cheng, H., Hancox, J. C., Orchard, C. H. and Smith, G. L. (2014) Acidosis slows electrical conduction through the atrio-ventricular node. Frontiers in Physiology, 5(233), (doi: 10.3389/fphys.2014.00233)
Hoydal, M.A., Kaurstad, G., Rolim, N.P., Johnsen, A.B., Alves, M., Koch, L.G., Britton, S.L., Stolen, T.O., Smith, G.L. and Wisloff, U. (2013) High inborn aerobic capacity does not protect the heart following myocardial infarction. Journal of Applied Physiology, 115(12), pp. 1788-1795. (doi: 10.1152/japplphysiol.00312.2013)
Kettlewell, S., Burton, F. L., Smith, G. L. and Workman, A. J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi: 10.1093/cvr/cvt087) (PMID:23568957) (PMCID:PMC3687753)
Lu, X., Ginsburg, K.S., Kettlewell, S., Bossuyt, J., Smith, G.L. and Bers, D.M. (2013) Measuring local gradients of intramitochondrial [Ca2+] in cardiac myocytes during sarcoplasmic reticulum Ca2+ release. Circulation Research, 112(3), pp. 424-431. (doi: 10.1161/CIRCRESAHA.111.300501)
Di Diego, J.M., Sicouri, S., Myles, R.C. , Burton, F., Smith, G.L. and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi: 10.1016/j.yjmcc.2012.10.017)
Elliott, E.B. et al. (2013) T. brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes. Cardiovascular Research, 100(2), pp. 325-335. (doi: 10.1093/cvr/cvt187) (PMID:23892734) (PMCID:PMC3797627)
Kelly, A., Ghouri, I.A., Kemi, O.J. , Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C. , Burton, F.L. and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi: 10.1161/CIRCEP.113.000334)
Cheng, H., Smith, G.L. , Orchard, C.H., Hancox, J.C. and Burton, F.L. (2012) Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits. Experimental Physiology, 97(10), pp. 1131-1139. (doi: 10.1113/expphysiol.2012.065110)
Workman, A.J. , Marshall, G.E., Rankin, A.C., Smith, G.L. and Dempster, J. (2012) Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes. Journal of Physiology, 590(17), pp. 4289-4305. (doi: 10.1113/jphysiol.2012.235986)
Elliott, E.B., Kelly, A., Smith, G.L. and Loughrey, C.M. (2012) Isolated rabbit working heart function during progressive inhibition of myocardial SERCA activity. Circulation Research, 110(12), pp. 1618-1627. (doi: 10.1161/CIRCRESAHA.111.262337)
Kemi, O. J. , MacQuaide, N. , Hoydal, M. A., Ellingsen, O., Smith, G. L. and Wisloff, U. (2012) Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats. Journal of Cellular Physiology, 227(1), pp. 20-26. (doi: 10.1002/jcp.22771)
Kelly, A., Elliott, E.B., Matsuda, R., Kaneko, N., Smith, G.L. and Loughrey, C.M. (2012) The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically-induced Ca2+ overload. British Journal of Pharmacology, 165(4b), pp. 1068-1083. (doi: 10.1111/j.1476-5381.2011.01531.x)
Chikando, A.C., Kettlewell, S., Williams, G.S., Smith, G.L. and Lederer, W.J. (2011) Ca2+ dynamics in the mitochondria - state of the art. Journal of Molecular and Cellular Cardiology, 51(5), pp. 627-631. (doi: 10.1016/j.yjmcc.2011.08.003) (PMID:21864537) (PMCID:PMC3814218)
Koch, L. G. et al. (2011) Intrinsic aerobic capacity sets a divide for aging and longevity. Circulation Research, 109(10), pp. 1162-1172. (doi: 10.1161/CIRCRESAHA.111.253807)
Kemi, O. J. , Hoydal, M. A., MacQuaide, N. , Haram, P. M., Koch, L. G., Britton, S. L., Ellingsen, O., Smith, G. L. and Wisloff, U. (2011) The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts. Journal of Cellular Physiology, 226(9), pp. 2235-2243. (doi: 10.1002/jcp.22559)
Stangherlin, A. et al. (2011) cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes. Circulation Research, 108(8), pp. 929-939. (doi: 10.1161/CIRCRESAHA.110.230698)
Myles, R. , Burton, F.L., Cobbe, S. and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi: 10.1016/j.yjmcc.2010.11.019)
Benson, A. P. et al. (2011) Construction and validation of anisotropic and orthotropic ventricular geometries for quantitative predictive cardiac electrophysiology. Interface Focus, 1(1), pp. 101-116. (doi: 10.1098/rsfs.2010.0005) (PMID:22419977) (PMCID:PMC3262240)
Currie, S., Elliott, E.B., Smith, G.L. and Loughrey, C.M. (2011) Two candidates at the heart of dysfunction: The ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention—An in vivo perspective. Pharmacology and Therapeutics, 131(2), pp. 204-220. (doi: 10.1016/j.pharmthera.2011.02.006)
Elliott, E.B., Hasumi, H., Otani, N., Matsuda, T., Matsuda, R., Kaneko, N., Smith, G.L. and Loughrey, C.M. (2011) K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca2+ release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes. Basic Research in Cardiology, 106(6), pp. 1009-1022. (doi: 10.1007/s00395-011-0218-4)
McMurray, J.J.V. and Smith, G.L. (2011) Calcium handling in the failing heart and SUMO — weighing the eviden. New England Journal of Medicine, (doi: 10.1056/NEJMcibr1110758)
Rota, M., Biesmans, L., MacQuaide, N. , Heinzel, F.R., Bito, V., Smith, G.L. and Sipido, K.R. (2011) Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density. PLoS ONE, 6(10), e25100. (doi: 10.1371/journal.pone.0025100)
Workman, A.J. , Smith, G.L. and Rankin, A.C. (2011) Mechanisms of termination and prevention of atrial fibrillation by drug therapy. Pharmacology and Therapeutics, 131(2), pp. 221-241. (doi: 10.1016/j.pharmthera.2011.02.002)
Toischer, K. et al. (2010) K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Research in Cardiology, 105(2), pp. 279-287. (doi: 10.1007/s00395-009-0057-8)
Craig, M. A., McBride, M. W. , Smith, G., George, S. and Baker, A. (2010) Dysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat. Journal of Molecular and Cellular Cardiology, 48(6), pp. 1121-1128. (doi: 10.1016/j.yjmcc.2010.01.017)
Klauke, N., Smith, G. and Cooper, J.M. (2010) Regional electroporation of single cardiac myocytes in a focused electric field. Analytical Chemistry, 82(2), pp. 585-592. (doi: 10.1021/ac901886j)
Miller, D. J. and Smith, G. L. (2010) Lüttgau & Niedergerke; the classic study of calcium-sodium antagonism half a century on. Journal of Physiology, 588(1), pp. 23-25. (doi: 10.1113/jphysiol.2009.184242) (PMID:20045904)
Cheng, W., Klauke, N., Smith, G. and Cooper, J.M. (2010) Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes. Electrophoresis, 31(8), pp. 1405-1413.
Eisner, D. A., George, C. H., Smith, G.L. , Trafford, A. W. and Venetucci, L. A. (2010) How does CaMKII phosphorylation of the cardiac ryanodine receptor contribute to inotropy? Proceedings of the National Academy of Sciences of the United States of America, 107(31), E123-E123. (doi: 10.1073/pnas.1008809107)
MacQuaide, N. , Ramay, H.R., Sobie, E.A. and Smith, G.L. (2010) Differential sensitivity of Ca2+ wave and Ca2+ spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes. Journal of Physiology, 588(23), pp. 4731-4742. (doi: 10.1113/jphysiol.2010.193375)
Myles, R.C. , Bernus, O., Burton, F.L., Cobbe, S.M. and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi: 10.1152/ajpheart.00518.2010)
Smith, G. , Reynolds, M., Burton, F.L. and Kemi, O.J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. Methods in Cell Biology, 99(10), pp. 255-261. (doi: 10.1016/B978-0-12-374841-6.00009-8)
Zamparelli, C., MacQuaide, N. , Colotti, G., Verzili, D., Seidler, T., Smith, G. L. and Chiancone, E. (2010) Activation of the cardiac Na+–Ca2+ exchanger by sorcin via the interaction of the respective Ca2+-binding domains. Journal of Molecular and Cellular Cardiology, 49(1), pp. 132-141. (doi: 10.1016/j.yjmcc.2010.03.003) (PMID:20298697) (PMCID:PMC2958309)
Fowler, M. and Smith, G.L. (2009) The cardiac contraction cycle: is Ca2+ going local? Journal of Applied Physiology, 107(6), pp. 1981-1984. (doi: 10.1152/japplphysiol.91168.2009)
Kettlewell, S., Seidler, T. and Smith, G.L. (2009) The effects of over-expression of the FK506-binding protein FKBP12.6 on K+ currents in adult rabbit ventricular myocytes. Pflügers Archiv - European Journal of Physiology, 458(4), pp. 653-660. (doi: 10.1007/s00424-009-0666-y)
Kettlewell, S., Cabrero, P., Nicklin, S.A. , Dow, J.A.T., Davies, S.A. and Smith, G.L. (2009) Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria. Journal of Molecular and Cellular Cardiology, 46(6), pp. 891-901. (doi: 10.1016/j.yjmcc.2009.02.016) (PMID:19249308)
MacQuaide, N. , Dempster, J. and Smith, G. L. (2009) Assessment of sarcoplasmic reticulum Ca2+ depletion during spontaneous Ca2+ waves in isolated permeabilized rabbit ventricular cardiomyocytes. Biophysical Journal, 96(7), pp. 2744-2754. (doi: 10.1016/j.bpj.2008.12.3944) (PMID:19348757) (PMCID:PMC2711300)
Fowler, M. R., Colotti, G., Chiancone, E., Higuchi, Y., Seidler, T. and Smith, G. L. (2009) Complex modulation of L-type Ca2+ current inactivation by sorcin in isolated rabbit cardiomyocytes. Pflügers Archiv - European Journal of Physiology, 457(5), pp. 1049-1060. (doi: 10.1007/s00424-008-0575-5)
Fowler, M.R. and Smith, G.L. (2009) Last word on viewpoint: the cardiac contraction cycle: is Ca2+ going local? Journal of Applied Physiology, 107(6), p. 1988. (doi: 10.1152/japplphysiol.01088.2009)
Kemi, O. , MacQuaide, N. , Hoydal, M.A., Haram, P.M., Ellingsen, O., Wisloff, U. and Smith, G. (2009) Exercise training reduces spontaneous Ca2+ waves in cardiomyocytes from post-myocardial infarction heart failure rats. Biophysical Journal, 96(3.S1), 274A-275A. (doi: 10.1016/j.bpj.2008.12.1359)
Klauke, N., Smith, G.L. and Cooper, J.M. (2009) Local regional stimulation of single isolated ventricular myocytes using microfluidics. Analytical Chemistry, 81(15), pp. 6390-6398. (doi: 10.1021/ac9008429)
Masson, R. et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53(4), pp. 694-700. (doi: 10.1161/HYPERTENSIONAHA.108.122333)
Stølen, T.O. et al. (2009) Interval training normalizes cCardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. Circulation Research, 105(6), pp. 527-536. (doi: 10.1161/CIRCRESAHA.109.199810)
Smith, G. and MacQuaide, N. (2008) Cytoplasmic versus intra-SR: the battle of the Ca2+ diffusion coefficients in cardiac muscle. Biophysical Journal, 95(3), pp. 1005-1006. (doi: 10.1529/biophysj.108.133926) (PMID:18469088) (PMCID:PMC2479579)
Kemi, O.J., Ellingsen, O., Smith, G.L. and Wisloff, U. (2008) Exercise-induced changes in calcium handling in left ventricular cardiomyocytes. Frontiers in Bioscience, 13, pp. 356-368. (doi: 10.2741/2685)
Fowler, M.R., Colotti, G., Chiancone, E., Smith, G.L. and Fearon, I.M. (2008) Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the alpha(1C) subunit in rabbits. Experimental Physiology, 93(12), pp. 1233-1238. (doi: 10.1113/expphysiol.2008.043497)
Kemi, O.J., Ceci, M., Condorelli, G., Smith, G.L. and Wisloff, U. (2008) Myocardial sarcoplasmic reticulurn Ca2+ ATPase function is increased by aerobic interval training. European Journal of Cardiovascular Prevention and Rehabilitation, 15(2), pp. 145-148. (doi: 10.1097/HJR.0b013e3282efd4e0)
Kemi, O.J., Ceci, M., Wisloff, U., Grimaldi, S., Gallo, P., Smith, G.L., Condorelli, G. and Ellingsen, O. (2008) Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy. Journal of Cellular Physiology, 214(2), pp. 316-321. (doi: 10.1002/jcp.21197)
Myles, R.C. , Burton, F.L., Cobbe, S.M. and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi: 10.1016/j.yjmcc.2008.03.024)
Schjerve, I. E. et al. (2008) Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults. Clinical Science, 115(9), pp. 283-293. (doi: 10.1042/CS20070332)
MacQuaide, N. , Dempster, J. and Smith, G.L. (2007) Measurement and modeling of Ca2+ waves in isolated rabbit ventricular cardiomyocytes. Biophysical Journal, 93(7), pp. 2581-2595. (doi: 10.1529/biophysj.106.102293) (PMID:17545234) (PMCID:PMC1965444)
Chilton, L., Giles, W.R. and Smith, G.L. (2007) Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts. Journal of Physiology, 583(1), pp. 225-236. (doi: 10.1113/jphysiol.2007.135038)
Klauke, N., Smith, G. and Cooper, J. M. (2007) Microfluidic systems to examine intercellular coupling of pairs of cardiac myocytes. Lab on a Chip, 7, pp. 731-739. (doi: 10.1039/b706175g)
Volkers, M. et al. (2007) S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium, 41(2), pp. 135-143. (doi: 10.1016/j.ceca.2006.06.001) (PMID:16919727)
Caldwell, J., Burton, F., Smith, G. and Cobbe, S. (2007) Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 18(8), pp. 854-861. (doi: 10.1111/j.1540-8167.2007.00867.x)
Hoydal, M., Wisloff, U., Kemi, O., Britton, S., Koch, L., Smith, G. and Ellingsen, O. (2007) Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity. European Journal of Cardiovascular Prevention and Rehabilitation, 14(2), pp. 319-325.
Kemi, O., Ellingsen, O., Ceci, M., Grimaldi, S., Smith, G., Condorelli, G. and Wisloff, U. (2007) Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban. Journal of Molecular and Cellular Cardiology, 43(3), pp. 354-361. (doi: 10.1016/j.yjmcc.2007.06.013)
Loughrey, C., Otani, N., Seidler, T., Craig, M., Matsuda, R., Kaneko, N. and Smith, G. (2007) K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes. Cardiovascular Research, 76(2), pp. 236-246. (doi: 10.1016/j.cardiores.2007.06.014)
Schillinger, W. et al. (2007) Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits - Evaluation of mechanisms. Circulation, 116(1), pp. 57-66. (doi: 10.1161/CIRCULATIONAHA.106.666008)
Seidler, T., Loughrey, C., Zibrova, D., Kettlewell, S., Teucher, N., Kogler, H., Hasenfuss, G. and Smith, G. (2007) Overexpression of FK-506-binding protein 12.0 modulates excitation-contraction coupling in adult rabbit ventricular cardiomyocytes. Circulation Research, 101(10), pp. 1020-1029. (doi: 10.1161/CIRCRESAHA.107.154609)
Smith, G. (2007) Matters of the heart: the physiology of cardiac function and failure. Experimental Physiology, 92(6), pp. 973-986. (doi: 10.1113/expphysiol.2007.034314)
Walker, N., Burton, F., Kettlewell, S., Smith, G. and Cobbe, S. (2007) Mapping of epicardial activation in a rabbit model of chronic myocardial infarction: Response to atrial, endocardial, and epicardial pacing. Journal of Cardiovascular Electrophysiology, 18(8), pp. 862-868. (doi: 10.1111/j.1540-8167.2007.00858.x)
Wisloff, U. et al. (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients - A randomized study. Circulation, 115(24), pp. 3086-3094. (doi: 10.1161/CIRCULATIONAHA.106.675041)
Cheng, W., Klauke, N., Sedgwick, H., Smith, G. L. and Cooper, J. M. (2006) Metabolic monitoring of the electrically stimulated single heart cell within a microfluidic platform. Lab on a Chip, 6(11), pp. 1424-1431. (doi: 10.1039/b608202e)
Smith, G. and MacQuaide, N. (2006) Swallowing a spider to catch a fly: ca-calmodulin dynamics in adult cardiomyocytes. Journal of Molecular and Cellular Cardiology, 41(3), pp. 416-417. (doi: 10.1016/j.yjmcc.2006.06.008) (PMID:16870208)
Colotti, G., Zamparelli, C., Verzili, D., Mella, M., Loughrey, C., Smith, G. and Chiancone, E. (2006) The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca2+-dependent interaction with annexin VII and the cardiac ryanodine receptor. Biochemistry, 45(41), pp. 12519-12529. (doi: 10.1021/bi060416a)
Kemi, O., Arbo, I., Hoydal, M., Loennechen, J., Wisloff, U., Smith, G. and Ellingsen, O. (2006) Reduced pH and contractility in failing rat cardiomyocytes. Acta Physiologica, 188(3-4), pp. 185-193. (doi: 10.1111/j.1748-1716.2006.01621.x)
Smith, G.L., Elliott, E.B., Kettlewell, S., Currie, S. and Quinn, F.R. (2006) Na+/Ca2+ Exchanger Expression and Function in a Rabbit Model of Myocardial Infarction. Journal of Cardiovascular Electrophysiology, 17(s1), S57-S63. (doi: 10.1111/j.1540-8167.2006.00384.x)
Currie, S., Quinn, F., Sayeed, R., Duncan, A., Kettlewell, S. and Smith, G. (2005) Selective down-regulation of sub-endocardial ryanodine receptor expression in a rabbit model of left ventricular dysfunction. Journal of Molecular and Cellular Cardiology, 39(2), pp. 309-317. (doi: 10.1016/j.yjmcc.2005.04.005)
Kettlewell, S., Most, P., Currie, S., Koch, W. and Smith, G. (2005) S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes. Journal of Molecular and Cellular Cardiology, 39(6), pp. 900-910. (doi: 10.1016/j.yjmcc.2005.06.018)
Kohl, P., Camelliti, P., Burton, F. and Smith, G. (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of Electrocardiology, 38(4), pp. 45-50. (doi: 10.1016/j.jelectrocard.2005.06.096)
Miller, S., Currie, S., Loughrey, C., Kettlewell, S., Seidler, T., Reynolds, D., Hasenfuss, G. and Smith, G. (2005) Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Cardiovascular Research, 67(4), pp. 667-677. (doi: 10.1016/j.cardiores.2005.04.023)
MacEachern, K.E. , Smith, G.L. and Nolan, A.M. (2004) Characteristics of the in vitro hypoxic pulmonary vasoconstrictor response in isolated equine and bovine pulmonary arterial rings. Veterinary Anaesthesia and Analgesia, 31(4), pp. 239-249. (doi: 10.1111/j.1467-2995.2004.00176.x) (PMID:15509288)
Loughrey, C.M. , Smith, G.L. and MacEachern, K.E. (2004) Comparison of Ca2+ release and uptake characteristics of the sarcoplasmic reticulum in isolated horse and rabbit cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 287(3), H1149-H1159. (doi: 10.1152/ajpheart.00060.2004) (PMID:15117716)
Loughrey, C.M. , Seidler, T., Miller, S.L.W., Prestle, J., MacEachern, K.E. , Reynolds, D.F., Hasenfuss, G. and Smith, G.L. (2004) Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes. Journal of Physiology, 556(3), pp. 919-934. (doi: 10.1113/jphysiol.2003.057166)
Currie, S., Loughrey, C., Craig, M. and Smith, G. (2004) Calcium/calmodulin-dependent protein kinase II delta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochemical Journal, 377(2), pp. 357-366. (doi: 10.1042/BJ200310431)
Kettlewell, S., Walker, N., Cobbe, S., Burton, F. and Smith, G. (2004) The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Experimental Physiology, 89(2), pp. 163-172. (doi: 10.1113/expphysiol.2003.026732)
Teucher, N. et al. (2004) Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening. Circulation, 110(23), pp. 3553-3559. (doi: 10.1161/01.CIR.0000145161.48545.B3)
Wokosin, D., Loughrey, C. and Smith, G. (2004) Characterization of a range of fura dyes with two-photon excitation. Biophysical Journal, 86(3), pp. 1726-1738. (doi: 10.1016/S0006-3495(04)74241-1)
Quinn, F.R., Currie, S., Duncan, A.M., Miller, S., Sayeed, R., Cobbe, S.M. and Smith, G.L. (2003) Myocardial infarction causes increased expression but decreased activity of the myocardial Na+-Ca2+ exchanger in the rabbit. Journal of Physiology, 553(1), pp. 229-242. (doi: 10.1113/jphysiol.2003.050716)
Loughrey, C.M. , MacEachern, K.E. , Cooper, J. and Smith, G.L. (2003) Measurement of the dissociation constant of Fluo-3 for Ca2+ in isolated rabbit cardiomyocytes using Ca2+ wave characteristics. Cell Calcium, 34(1), pp. 1-9. (doi: 10.1016/S0143-4160(03)00012-5) (PMID:12767887)
McConnell, G., Smith, G., Girkin, J., Gurney, A. and Ferguson, A. (2003) Two-photon microscopy of fura-2-loaded cardiac myocytes with an all-solid-state tunable and visible femtosecond laser source. Optics Letters, 28(19), pp. 1742-1744. (doi: 10.1364/OL.28.001742)
Most, P. et al. (2003) The C terminus (amino acids 75-94) and the linker region (amino acids 42-54) of the Ca2+-binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibers. Journal of Biological Chemistry, 278(29), pp. 26356-26364. (doi: 10.1074/jbc.M303338200)
Prestle, J., Quinn, F. and Smith, G. (2003) Ca2+-handling proteins and heart failure: Novel molecular targets? Current Medicinal Chemistry, 10(11), pp. 967-981.
Seidler, T. et al. (2003) Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Circulation Research, 93(2), pp. 132-139. (doi: 10.1161/01.RES.0000081596.90205.E2)
Zhang, H. et al. (2003) Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. International Journal of Bifurcation and Chaos, 13(12), pp. 3535-3560. (doi: 10.1142/S0218127403008843)
Loughrey, C.M. , MacEachern, K.E. , Neary, P. and Smith, G.L. (2002) The relationship between intracellular [Ca2+] and Ca2+ wave characteristics in permeabilised cardiomyocytes from the rabbit. Journal of Physiology, 543(3), pp. 859-870. (doi: 10.1113/jphysiol.2002.021519) (PMID:12231644)
Neary, P., Duncan, A.M., Cobbe, S.M. and Smith, G.L. (2002) Assessment of sarcoplasmic reticulum Ca2+ flux pathways in cardiomyocytes from rabbits with infarct-induced left-ventricular dysfunction. Pflügers Archiv - European Journal of Physiology, 444(3), pp. 360-371. (doi: 10.1007/s00424-002-0794-0)
Ng, G.A., Hicks, M.N., Cobbe, S.M. and Smith, G.L. (2002) Depressed inotropic response to increased preload in rabbit hearts with left-ventricular dysfunction induced by chronic myocardial infarction. Pflügers Archiv - European Journal of Physiology, 444(4), pp. 513-522. (doi: 10.1007/s00424-002-0848-3)
Cai, X., Klauke, N., Glidle, A., Cobbold, P., Smith, G.L. and Cooper, J.M. (2002) Ultra-low-volume, real-time measurements of lactate from the single heart cell using microsystems technology. Analytical Chemistry, 74(4), pp. 908-914. (doi: 10.1021/ac010941+)
Wisloff, U., Loennechen, J., Currie, S., Smith, G. and Ellingsen, O. (2002) Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction. Cardiovascular Research, 54(1), pp. 162-174. (doi: 10.1016/S0008-6363(01)00565-X)
Smith, G.L. and ONeill, S.C. (2001) A comparison of the effects of ATP and tetracaine on spontaneous Ca2+ release from rat permeabilised cardiac myocytes. Journal of Physiology, 534(1), pp. 37-47. (doi: 10.1111/j.1469-7793.2001.00037.x)
Most, P. et al. (2001) S100A1: A regulator of myocardial contractility. Proceedings of the National Academy of Sciences of the United States of America, 98(24), pp. 13889-13894. (doi: 10.1073/pnas.241393598)
Prestle, J., Janssen, P., Janssen, A., Zeitz, O., Lehnart, S., Bruce, L., Smith, G. and Hasenfuss, G. (2001) Overexpression of FK506-Binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca2+ leak from the sarcoplasmic reticulum and increases contractility. Circulation Research, 88(2), pp. 188-194.
Wisloff, U., Loennechen, J., Falck, G., Beisvag, V., Currie, S., Smith, G. and Ellingsen, O. (2001) Increased contractility and calcium sensitivity in cardiac myocytes isolated from endurance trained rats. Cardiovascular Research, 50(3), pp. 495-508. (doi: 10.1016/S0008-6363(01)00210-3)
MacEachern, K.E. , Smith, G.L. and Nolan, A.M. (1997) Methods for the isolation, culture and characterisation of equine pulmonary artery endothelial cells. Research in Veterinary Science, 62(2), pp. 147-152. (doi: 10.1016/S0034-5288(97)90137-5) (PMID:9243714)
MacFarlane, N.G., Miller, D.J., Smith, G.L. and Steele, D.S. (1994) Effects of oxidants on the sarcoplasmic reticulum of saponin treated rat ventricular trabeculae. Cardiovascular Research, 28(11), pp. 1647-1652. (doi: 10.1093/cvr/28.11.1647) (PMID:7842458)
Book Sections
MacCannell, K.A., Chilton, L., Smith, G.L. and Giles, W.R. (2015) Mathematical simulations of sphingosine-1-phosphate actions on mammalian ventricular myofibroblasts and myocytes. In: Dixon, I. M.C. and Wigle, J. T. (eds.) Cardiac Fibrosis and Heart Failure: Cause or Effect? Series: Advances in biochemistry in health and disease. Springer: Cham, pp. 299-322. ISBN 9783319174365 (doi: 10.1007/978-3-319-17437-2_16)
Smith, G. , Reynolds, M., Burton, F. and Kemi, O. J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. In: Whitaker, M. (ed.) Calcium in Living Cells. Series: Methods in cell biology (99). Elsevier, pp. 225-261. ISBN 9780123748416 (doi: 10.1016/B978-0-12-374841-6.00009-8)
Conference or Workshop Item
MacEachern, K.E. , Smith, G. and Nolan, A.M. (1997) The Role of Endothelins in Equine Pulmonary Arteries in Vitro. Journal of Veterinary Pharmacology and Therapeutics 20(Suppl 1): S246. 7th European Association for Veterinary Pharmacology and Toxicology (EAVPT) International Congress, Madrid, Spain, 06-10 Jul 1997.
MacEachern, K.E. , Smith, G.L. and Nolan, A.M. (1996) Characterisation of Equine Vascular Endothelial Cells in vitro. Association of Veterinary Teachers and Research Workers Jubilee Meeting, Scarborough, UK, 02-04 Apr 1996.
MacEachern, K.E. , Smith, G.L. and Nolan, A.M. (1995) Investigation of the Hypoxic Pulmonary Vasoconstrictor Response in Horse Tissue. British Equine Veterinary Congress, Harrogate, UK, 1995.
Conference Proceedings
Astrauskaite, G., Mohanan, S. , Williamson, L., Boland, E., Huethorst, E. , Kinegawa, R., Smith, G. and Muellenbroich, C. (2024) Remote Focusing for 2-photon Microscopy to Follow Action Potential Propagation Transmurally in Acute Rabbit Cardiac Slices. In: SPIE BiOS 2024, San Francisco, CA, USA, 27 January - 1 February 2024, ISBN 9781510669536 (doi: 10.1117/12.3002956)
Campbell, A. S., Burton, F. L., Baillie, G. and Smith, G. L. (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway. In: 58th Annual Meeting of the Biophysical-Society, San Francisco CA, USA, 15-19 Feb 2014, 119a.
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Chronic myocardial infarction in rabbits to evaluate next generation therapeutics
British Heart Foundation
2024 - 2025
- Fluorescence Imaging using Random Access Parallel Microscopy for Cardiac Toxicity Screening.
Tenovus Scotland
2023 - 2024
- High-speed optical mapping platform for assessing cardiotoxicity
Engineering and Physical Sciences Research Council
2023 - 2024
- Fibroblast activation in right ventricular disease: a primer for non-invasive molecular imaging
Academy of Medical Sciences
2023 - 2025
- Correlative Optical investiagtion of cardiac Eletrophysiology Under Remodelling
British Heart Foundation
2022 - 2025
- Therapeutic Manipulation of NCX1 activity
British Heart Foundation
2022 - 2025
- BHF Centre for Cardiovascular Regenerative Medicine Award
British Heart Foundation
2021 - 2024
- Targeting PDE3/4 to allow regulation of cardiac calcium homeostasis in disease
British Heart Foundation
2021 - 2023
- Pharmacological and dynamic-clamp narrowing of the calcium current window to inhibit human atrial early after depolarisations and atrial fibrillation.
British Heart Foundation
2021 - 2024
- The SofTMech Statistical Emulation and Translation Hub
Engineering and Physical Sciences Research Council
2021 - 2025
- Adrenergic modulation of ventricular conduction velocity is a novel modulator of electrical excitability in health and disease
British Heart Foundation
2019 - 2022
- Development of a model of insulin-stimulated glucose transport in human cardiomyocytes
British Heart Foundation
2018 - 2020
- Elucidation of molecular pathways underlying cardiac disease caused by Col4a1 mutations
Heart Research UK
2018 - 2021
- Investigating the Therapeutic Potential of Runx1 for Myocardial Infarction
British Heart Foundation
2018 - 2022
- Palmitoylation of the L-Type Ca Channel Pore-Forming Subunit
British Heart Foundation
2018 - 2021
- BHF Centre for Cardiovascular Regenerative Medicine Award (II) - Imperial College
British Heart Foundation
2017 - 2019
- Cardiac gene therapy with angiotensin-(1-9): dissecting the underlying mechanism for preservation of cardiac function post-myocardial infarction
British Heart Foundation
2017 - 2020
- Investigating the influence of myofibroblast coupling on cardiac conduction and infarct electrophysiology
British Heart Foundation
2017 - 2020
- Adrenoceptor-subtype antagonism profiles with anti-arrhythmic potential in human atrial myocytes
British Heart Foundation
2017 - 2020
- Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicine
Engineering and Physical Sciences Research Council
2016 - 2021
- EPSRC Centre for Multiscale soft tissue mechanics with application to heart & cancer
Engineering and Physical Sciences Research Council
2016 - 2020
- Be-Optical
European Commission
2015 - 2019
- INVESTIGATING THE ROLE OF RUNX1 IN THE HEART POST-MYOCARDIAL INFARCTION
Medical Research Council
2015 - 2018
- Afib-TrainNet
European Commission
2015 - 2019
- The role of sarcoplasmic reticulum calcium in the generation of early after-depolarisations and ventricular arrhythmias in the long QT syndrome
British Heart Foundation
2015 - 2018
- Investigating the mechanisms of low-voltage defibrillation and its application to the human ventricle to facilitate its translation into the clinic
British Heart Foundation
2015 - 2017
- Development of ultrafast lasers in biomedical multiphoton applications - QuantIC Partnership
Engineering and Physical Sciences Research Council
2014 - 2019
- Engineered 2D & 3D hiPSC-CM platforms to detect cardiovascular safety liabilities
National Centre for the Replacement of Animals Research
2014 - 2018
- Monitoring contractlitiy of bio-realistic human cardiac tissue in-vitro ref CRACK IT Challenges 35587-259131
National Centre for the Replacement of Animals Research
2014 - 2014
- Human atrial action potential alternans and afterdepolarisations: electrophysiological and calcium-cycling mechanisms and effects of myocardial disease
British Heart Foundation
2013 - 2017
- The role of RyR cluster morphology in Ca2+ homeostasis
British Heart Foundation
2013 - 2018
- Investigating the therapeutic potential of cathepsin-L inhibition to limit ischaemia-reperfusion injury in the heart
Chief Scientist Office
2013 - 2016
- IAA-EPSRC: Upgrade of cellOPTIQ function to allow simultaneous multiple fluorescence measurements
Engineering and Physical Sciences Research Council
2012 - 2015
- Electrophysiology Chip on a Microfluidic Platform
Biotechnology and Biological Sciences Research Council
2011 - 2014
- Cardiac CaMK in heart failure and exercise training
British Heart Foundation
2010 - 2013
- Project "CLYDE" Spin-Out.
Synergy Fund
2009 - 2011
- EUTrigTreat - Indentification and therapeutic targeting of common arrhythmia trigger mechanisms
European Commission
2009 - 2014
- Identification and therapeutic targeting of common arrhythmia trigger mechanisms
European Commission
2009 - 2015
- KTA-EPSRC:Design and production of demo prototype of CellOPTIQ
Engineering and Physical Sciences Research Council
2009 - 2012
- Production of cardiomyocytes from human embryonic stem cells
Stem Cells for Safer Medicines
2009 - 2010
- Atrial remodelling of calcium handling and electrophysiology in heart failure.
British Heart Foundation
2009 - 2013
- Cellular basis for alternating T-wave morphology in isolated rabbit hearts
British Heart Foundation
2009 - 2012
- Hypothermia - Competence programme in diving
Norwegian University of Science and Technology
2008 - 2008
- Scottish Universities Life Sciences Alliance (SULSA)- Cell Biology
Scottish Funding Council
2008 - 2015
- Does ACE2 have a protective role in the heart? Systematic analysis of ACE2 in a disease model
British Heart Foundation
2007 - 2010
- Targeted disruption of sarcoplasmic reticulum mediated Ca2+ handling and diastolic dysfunction: A comaprison between isolated cardiomyocytes and the whole heart.
Heart Research UK
2007 - 2009
- Heartwave II Microvolt T-wave alternans system
Norwegian University of Science and Technology
2007 - 2007
- The effect of Ca2+ microdomains on Ca2+ dependent processes in cardiac ventricular myocytes
British Heart Foundation
2007 - 2010
- Investigating the role of intracellular calcium in the left ventricular diastolic dysfunction
Medical Research Scotland
2006 - 2008
- The role of repolarisation alternans in ventricular arrhythmia in a rabbit model of heart failure
British Heart Foundation
2006 - 2009
- Unravelling the effect of cadherin dysregulation in the heart
Wellcome Trust
2006 - 2007
- Cellular Basis of Arrhythmias:The Inter-Relationship between Ca2+ Transients and Ca2+ Waves in Cardiac Muscle
British Heart Foundation
2006 - 2009
- Effect of Acidosis on the cardiac atrio-ventricular node
British Heart Foundation
2005 - 2006
- Investigation of calcium signalling in sarcoplasmic riticulum of cardiac myocytes using a novel targeted reporter
Biotechnology and Biological Sciences Research Council
2005 - 2008
- Atrioventricular nodal function in a rabbit model of chronic heart failure
British Heart Foundation
2005 - 2007
- Electrophysiology of ventricular myofybroblasts within myocardial infarction scars of rabbit hearts
British Heart Foundation
2005 - 2005
- High Fidelity Phenotyping combined with genomics, proteomics and metabonomics close to the patient
British Heart Foundation
2004 - 2008
- A longitudinal study of myocardial remodelling following infarction in the rabbit heart
British Heart Foundation
2004 - 2009
- A study of the subcellular actions of sorcin in ventricular cardiac muscle
British Heart Foundation
2004 - 2007
- Factors affecting the success of defibrillation in ischaemia
British Heart Foundation
2004 - 2007
- A study of the mechanisms and dynamics of action potential adaptation to increase in heart rate
British Heart Foundation
2002 - 2005
- The role of FK binding proteins in the modulation of excitation-contraction coupling in cardiac muscle
Wellcome Trust
2002 - 2005
Supervision
- Forbes, Sasha
Use of iPSC organoid spheres to bridge slow conduction and treat scar-based arrhythmias in ventricular myocardium - Gilchrist, Rebecca
The role of population heterogeneity in electrophysiology in - Moreno, Steven Milan
Light-sheet microscopy for whole-heart imaging in health and disease
Research datasets
2023
Simitev, R. D. , Al dawoud, A. M. A., Aziz, M. H. N., Myles, R. and Smith, G. (2023) Phenomenological analysis of simple ion channel block in large populations of uncoupled cardiomyocytes. [Data Collection]
2020
Simitev, R. , Smith, G. , Gao, H. and Mortensen, P. (2020) Action potential propagation and block in a model of atrial tissue with myocyte-fibroblast coupling. [Data Collection]
Additional information
Editorial Board
- 1999 - present: Experimental Physiology - Journal Editor
Grant Advisory Board
- 2001 - 2005: British Heart Foundation - Project Grants Committee
Invited International Presentations
- 2004: The International Society for Cardiovascular Research Symposium - Heart failure, disorders of Ca handling
- 2004: Trondheim, Norway - "Cellular Biology of Exercise Training in Cardiovascular Disease"
- 2004: The British Society for Cardiovascular Research meeting - Integrative cardiovascular pathophysiology in gene-modified models.
- 2004: Lundsbrunn Spa, Sweden - Scandinavian Physiological Society Meeting on: Transport and membrane trafficking in cells
- 2002: Lillehamer, Norway - Annual meeting of the Norwegian Cardiology Society
- 2002: London, England - The British Society for Cardiovascular Research meeting on: Ion Channels and Transporters in Cardiovascular cell growth
- 2002: London, England - The Physiological Society on: Cardiac electrophysiology, heterogeneity in the heart
- 2002: Cavalese, Italy - 12th International Symposium on Calcium-Binding Proteins and Calcium Function in Health and Disease
- 2002: London, England - The Physiological Society Symposium on the Athletes Heart
Prizes, Awards and Distinctions
- 2005: Physiological Society, G.L. Brown Prize Lecture
Professional Learned Society
- 2003 - present: British Cardiac Society - Member
- 1995 - present: British Society for Cardiovascular Research - Member
- 1993 - present: Biophysical Society - USA - Member
- 1986 - present: Physiological Society - Grants Subcommittee 1999-2005, Dale and Rushton Fund Co-treasurer 1999-2005, Further Education Subcommittee 1999-2002, Memberships Committee (Chair) 2002-05, Council Member 1998-2004
Research Fellowship
- 1988 - 1991: British Heart Foundation Fellowship
