Dr Rucha Karnik
- Royal Society University Research Fellow (Institute of Molecular Cell and Systems Biology)
I obtained my Bachelor’s degree in Biochemistry (St Xavier’s College, Ahmedabad) and Masters in Biotechnology from the Gujarat University in India, earned with a 1st rank in the Masters programme. I then spent over six years in the pharma-biotech industry where I worked on research, marketing and management aspects of various projects including development of recombinant protein-based diagnostic kits, human therapeutics, biosimilars and the agro-biotech business. Drawn to fundamental research in human disease, I left the industry and moved to the UK to pursue my PhD at the University of Leeds, in the Institute of Membrane and Systems Biology. I was awarded fellowships from the prestigious Overseas Research Students Awards Scheme (ORSAS) sponsored by the British government, the Tetley & Lupton Scholarship and the International Research Scholarship from the University of Leeds for my PhD. At Leeds, I investigated membrane traffic of human K+ channels and its implications for health and disease. For my postdoc, I joined Mike Blatt’s group at the University of Glasgow (2011) where I started working with plants. I have since pursued closely related themes of membrane transport, regulation of membrane traffic and cellular homeostasis, developing a fundamental interest in molecular mechanisms of vesicle traffic and its coordination with transport, which are critical for plant physiology. As a Royal Society University Research Fellow, the University of Glasgow continues to be my home. To achieve food security in the face of global environment change, it is essential that we improve agricultural crops for efficient growth, nutrient uptake, CO2 and water utilisation and responses to biotic stresses. Therefore, research directed to understanding, predicting, and manipulating the molecular mechanisms of plant growth and responses to the environment is at the forefront of scientific interest. My research focus centres around understainding the role of hormone regulated membrane traffic in plant growth and homeostasis.
• Hormone modulate membrane traffic
• Functional regulation of Ion transporters
|Mr Craig Bruce|
Royal Society Funded PhD Studentship available in the Karnik Lab
Application Deadline: 24th March 2017 or until filled
Start Date: 1st October 2017.
Proton Transport Modulators - Spatial Regulation and Effects on Plant Physiology
Outline and Aim:
One of the biggest challenges faced by the world is sustaining water and food availability to meet the demands of the rapidly increasing human population. Research to understand how plants grow and develop is therefore vital. The ‘acid growth’ hypothesis has long promoted the idea that plasma membrane H+ pumps (H+-ATPases) are regulated to promote acid (H+) transport and generate turgor pressure to drive cell expansion. Mechanisms underlying hormonal control of proton pump traffic and links to functional regulation of the proton pump are unknown. This studentship is funded by a Royal Society grant to identify mechanisms of hormone regulated membrane traffic of effectors that affect functional regulation of the proton transporters at a molecular, cellular and whole organism level.
The student will employ a multidisciplinary approach and gain expertise in cross-platform techniques and concepts in cell biology, molecular cloning, membrane transport and genetics as well as specialised methodologies adapted to study protein-protein interactions using yeast and proteomics. Skills training will include protein biochemistry, in vivo and in vitro protein-protein interaction assays, fluorescence microscopy and optobiology. Electrophysiology studies and training will be carried out in collaboration with Professor Mike Blatt, Regius Professor of Botany, Institute of Molecular, Cell and Systems Biology, at the University of Glasgow. Opportunities to train and learn from the diverse and vibrant research community at the IMCSB in the University of Glasgow will be available as relevant to the project.
Funding: This studentship is funded by a grant from the Royal Society for 4 years. Support includes an annual stipend at RCUK rates for 4 years (£14,296 per year), PhD registration fees at UK/EU student rate (£4121 per year).
Requirements: Applicants must have at least an upper second class BSc or the equivalent degree. Proficiency in basic molecular biology skills is required and knowledge of membrane biology, biochemistry and cell biology is preferred.
Interested candidates should contact Dr Rucha Karnik directly by email at email@example.com with a CV giving and a brief statement of what they could bring to this project.
1. Hager, A. et al., Planta (1991)185, 527
2. Hager, A. et al., J. of plant res. (2003) 116, 483
3. Spartz, A. et al., Plant Cell (2014) 26, 2129
4. R. Karnik et al., Trends Plant Sci (2017) 22, 81
For formal applications, please visit: http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Proton Transport Modulators - Spatial Regulation and Effects on Plant Physiology
2017 - 2021
- Hormone-Regulated Membrane Traffic and Plant Morphogenesis
2016 - 2021