Dr Willie Weir

  • Bioinformatician (Institute of Biodiversity Animal Health and Comparative Medicine)
  • Associate Academic (School of Veterinary Medicine)

telephone: 01413305721
email: Willie.Weir@glasgow.ac.uk

Research interests

My research is mainly in the field of veterinary infectious disease, principally tick-borne pathogens (Babesia, Theileria and Anaplasma), Cryptosporidium and Trypanosomes. I apply population genetic and genomic approaches to investigate diversity in pathogen populations together with transcriptomics, which allows the characterisation of cellular interactions at the host/parasite interface.

I am particularly interested in emerging tick-borne veterinary pathogens in the UK, such as equine piroplasmosis, and the development of novel diagnostic assays for their detection.

A recently completed active surveillance study, the TickTag project, has revealed a zoonotic protozoan pathogen in Scottish livestock, which has not previously been identified in the UK.

I am also interested in the identification and validation of novel biomarkers for both infectious and non-infectious disease. This entails the bioinformatic mining of high-throughput sequencing datasets for veterinary diagnostic and prognostic applications. The ultimate goal of this research is the development of novel assays which will assist veterinary surgeons in their clinical decision making.

Google Scholar

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Scottish Partnership for Animal Science Excellence
    Rural and Environment Research and Analysis Directorate
    2015 - 2016
     
  • Quantifying multiple strain infections for a tick-borne pathogen using next-generation sequencing (ISSF STS)
    Wellcome Trust
    2015 - 2015
     
  • Scottish Partnership for Animal Science Excellence
    Rural and Environment Research and Analysis Directorate
    2014 - 2015
     
  • Scottish Partnership for Animal Science Excellence
    Rural and Environment Research and Analysis Directorate
    2013 - 2014
     

Publications

List by: Type | Date

Jump to: 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2007 | 2006 | 2005 | 2003
Number of items: 44.

2016

Patakas, A., Ji, R.-R., Weir, W., Connolly, S. E., Benson, R. A., Nadler, S. G., McInnes, I. B., and Garside, P. (2016) Abatacept inhibition of T cell priming in mice by induction of a unique transcriptional profile that reduces their ability to activate antigen-presenting cells. Arthritis and Rheumatism, 68(3), pp. 627-638. (PMID:26473409)

Patakas, A., Ji, R., Weir, W., Connolly, S. E., Benson, R. A., Nadler, S. G., Brewer, J. M., McInnes, I. B., and Garside, P. (2016) Abatacept inhibits T cell priming by inducing of a unique transcriptional profile that reduces their ability to activate antigen presenting cells. Arthritis and Rheumatology, 68(3), pp. 627-638. (doi:10.1002/art.39470) (PMID:26473409)

Bilgic, H. B., Karagenc, T., Bakırc, S., Shiels, B., Tait, A., Kinnaird, J., Eren, H., and Weir, W. (2016) Identification and analysis of immunodominant antigens for ELISA-based detection of Theileria annulata. PLoS ONE, (Accepted for Publication)

Weir, W. et al. (2016) Population genomics reveals the origin and asexual evolution of human infective trypanosomes. eLife, 5, e11473. (doi:10.7554/eLife.11473) (PMID:26809473) (PMCID:PMC4739771)

2015

Bishop, R.P., Hemmink, J.D., Morrison, W.I., Weir, W., Toye, P.G., Sitt, T., Spooner, P.R., Musoke, A.J., Skilton, R.A., and Odongo, D.O. (2015) The African buffalo parasite Theileria. sp. (buffalo) can infect and immortalize cattle leukocytes and encodes divergent orthologues of Theileria parva antigen genes. International Journal for Parasitology: Parasites and Wildlife, 4(3), pp. 333-342. (doi:10.1016/j.ijppaw.2015.08.006) (PMID:26543804) (PMCID:PMC4589832)

Pieszko, M., Weir, W., Goodhead, I., Kinnaird, J., and Shiels, B. (2015) ApiAP2 factors as candidate regulators of stochastic commitment to merozoite production in Theileria annulata. PLoS Neglected Tropical Diseases, 9(8), e0003933. (doi:10.1371/journal.pntd.0003933) (PMID:26273826) (PMCID:PMC4537280)

Capewell, P., Cooper, A., Clucas, C., Weir, W., and Macleod, A. (2015) A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome. Parasitology, 142(S1), S108-S119. (doi:10.1017/S0031182014000602) (PMID:25656360) (PMCID:PMC4413828)

Al-Hamidhi, S. et al. (2015) Genetic diversity and population structure of Theileria annulata in Oman. PLoS ONE, 10(10), e0139581. (doi:10.1371/journal.pone.0139581) (PMID:26469349) (PMCID:PMC4607491)

Capewell, P., Cooper, A., Clucas, C., Weir, W., Vaikkinen, H., Morrison, L., Tait, A., and MacLeod, A. (2015) Exploiting genetic variation to discover genes involved in important disease phenotypes. Methods in Molecular Biology, 1201, pp. 91-107. (doi:10.1007/978-1-4939-1438-8_5) (PMID:25388109)

Carletti, T., Barreto, C., Mesplet, M., Mira, A., Weir, W., Shiels, B., Oliva, A. G., Schnittger, L., and Florin-Christensen, M. (2015) Characterization of a papain-like cysteine protease essential for the survival of Babesia ovis merozoites. Ticks and Tick-borne Diseases, (doi:10.1016/j.ttbdis.2015.09.002) (PMID:26456355)

Winter, A. D. et al. (2015) A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites. BMC Genomics, 16, 331. (doi:10.1186/s12864-015-1536-y) (PMID:25896062) (PMCID:PMC4428239)

Woolhouse, M. E. J. et al. (2015) Co-infections determine patterns of mortality in a population exposed to parasite infection. Science Advances, 1(2), e1400026. (doi:10.1126/sciadv.1400026)

2014

Jackson, A. P. et al. (2014) The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction. Nucleic Acids Research, 42(11), pp. 7113-7131. (doi:10.1093/nar/gku322) (PMID:24799432) (PMCID:PMC4066756)

2013

Braceland, M., Bickerdike, R., Tinsley, J., Cockerill, D., Mcloughlin, M.F., Graham, D.A., Burchmore, R.J., Weir, W., Wallace, C., and Eckersall, P.D. (2013) The serum proteome of Atlantic salmon, Salmo salar, during pancreas disease (PD) following infection with salmonid alphavirus subtype 3 (SAV3). Journal of Proteomics, 94, pp. 423-436. (doi:10.1016/j.jprot.2013.10.016)

Capewell, P., Clucas, C., Weir, W., Veitch, N., and MacLeod, A. (2013) Normal human serum lysis of non-human trypanosomes and resistance of T. b. rhodesiense and T. b. gambiense. In: Magez, S. and Radwanska, M. (eds.) Trypanosomes and Trypanosomiasis. Springer, pp. 139-160. ISBN 9783709115558 (doi:10.1007/978-3-7091-1556-5_6)

Asiimwe, B.B., Weir, W., Tait, A., Lubega, G.W., and Oura, C.A.L. (2013) Haemoparasite infection kinetics and the population structure of Theileria parva on a single farm in Uganda. Veterinary Parasitology, 193(1-3), pp. 8-14. (doi:10.1016/j.vetpar.2012.12.017)

Bilgiç, H. B., Karagenç, T., Simuunza, M., Shiels, B., Tait, A., Eren, H., and Weir, W. (2013) Development of a multiplex PCR assay for simultaneous detection of Theileria annulata, Babesia bovis and Anaplasma marginale in cattle. Experimental Parasitology, 133(2), pp. 222-229. (doi:10.1016/j.exppara.2012.11.005)

Capewell, P., Clucas, C., DeJesus, E., Kieft, R., Hajduk, S., Veitch, N., Steketee, P.C., Cooper, A., Weir, W., and MacLeod, A. (2013) The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense. PLoS Pathogens, 9(10), e1003686. (doi:10.1371/journal.ppat.1003686) (PMID:24098129) (PMCID:PMC3789759)

Hayashida, K., Abe, T., Weir, W., Nakao, R., Ito, K., Kajino, K., Suzuki, Y., Jongejan, F., Geysen, D., and Sugimoto, C. (2013) Whole-genome sequencing of Theileria parva strains provides insight into parasite migration and diversification in the african continent. DNA Research, 20(3), pp. 209-220. (doi:10.1093/dnares/dst003)

Kinnaird, J.H., Weir, W., Durrani, Z., Pillai, S.S., Baird, M., and Shiels, B.R. (2013) A bovine lymphosarcoma cell line infected with theileria annulata exhibits an irreversible reconfiguration of host cell gene expression. PLoS ONE, 8(6), e66833. (doi:10.1371/journal.pone.0066833)

2012

Durrani, Z., Weir, W., Pillai, S., Kinnaird, J., and Shiels, B. (2012) Modulation of activation-associated host cell gene expression by the apicomplexan parasite Theileria annulata. Cellular Microbiology, 14(9), pp. 1434-1454. (doi:10.1111/j.1462-5822.2012.01809.x)

Hayashida, K. et al. (2012) Comparative genome analysis of three eukaryotic parasites with differing abilities to transform leukocytes reveals key mediators of Theileria-induced leukocyte transformation. MBIO, 3(5), e00204-12. (doi:10.1128/mBio.00204-12)

Winter, A.D., Weir, W., Hunt, M., Berriman, M., Gilleard, J.S., Devaney, E., and Britton, C. (2012) Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel. BMC Genomics, 13, p. 4. (doi:10.1186/1471-2164-13-4)

2011

Oura, C.A.L., Tait, A., Asiimwe, B., Lubega, G.W., and Weir, W. (2011) Theileria parva genetic diversity and haemoparasite prevalence in cattle and wildlife in and around Lake Mburo National Park in Uganda. Parasitology Research, 108(6), pp. 1365-1374. (doi:10.1007/s00436-010-2030-8)

Simuunza, M., Bilgic, H., Karagenc, T., Syakalima, M., Shiels, B., Tait, A., and Weir, W. (2011) Population genetic analysis and sub-structuring in Babesia bovis. Molecular and Biochemical Parasitology, 177(2), pp. 106-115. (doi:10.1016/j.molbiopara.2011.02.002)

Connelley, T.K., MacHugh, N.D., Pelle, R., Weir, W., and Morrison, W.I. (2011) Escape from CD8+ T cell response by natural variants of an immunodominant epitope from Theileria parva is predominantly due to loss of TCR recognition. Journal of Immunology, 187(11), pp. 5910-5920. (doi:10.4049/jimmunol.1102009)

Gharbi, M. et al. (2011) Prime-boost immunisation against tropical theileriosis with two parasite surface antigens: Evidence for protection and antigen synergy. Vaccine, 29(38), pp. 6620-6628. (doi:10.1016/j.vaccine.2011.06.109)

MacHugh, N. D., Weir, W., Burrells, A., Lizundia, R., Graham, S.P., Taracha, E.L., Shiels, B.R., Langsley, G., and Morrison, W.I. (2011) Extensive polymorphism and evidence of immune selection in a highly dominant antigen recognized by bovine CD8 T cells specific for Theileria annulata. Infection and Immunity, 79(5), pp. 2059-2069. (doi:10.1128/IAI.01285-10)

Oura, C.A.L., Tait, A., Asiimwe, B., Lubega, G.W., and Weir, W. (2011) Haemoparasite prevalence and Theileria parva strain diversity in Cape buffalo (Syncerus caffer) in Uganda. Veterinary Parasitology, 175(3-4), pp. 212-219. (doi:10.1016/j.vetpar.2010.10.032)

Pelle, R. et al. (2011) Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity. PLoS ONE, 6(4), e19015. (doi:10.1371/journal.pone.0019015)

Simuunza, M., Weir, W., Courcier, E., Tait, A., and Shiels, B. (2011) Epidemiological analysis of tick-borne diseases in Zambia. Veterinary Parasitology, 175(3-4), pp. 331-342. (doi:10.1016/j.vetpar.2010.09.027)

Weir, W., Karagenç, T., Gharbi, M., Simuunza, M., Aypak, S., Aysul, N., Darghouth, M. A., Shiels, B., and Tait, A. (2011) Population diversity and multiplicity of infection in Theileria annulata. International Journal for Parasitology, 41(2), pp. 193-203. (doi:10.1016/j.ijpara.2010.08.004)

2010

Schmuckli-Maurer, J., Kinnaird, J., Pillai, S., Hermann, P., McKellar, S., Weir, W., Dobbelaere, D., and Shiels, B. (2010) Modulation of NF-kappaB activation in Theileria annulata-infected cloned cell lines is associated with detection of parasite-dependent IKK signalosomes and disruption of the actin cytoskeleton. Cellular Microbiology, 12(2), pp. 158-173. (doi:10.1111/j.1462-5822.2009.01386.x)

Bilgic, H.B., Karagenç, T., Shiels, B., Tait, A., Eren, H., and Weir, W. (2010) Evaluation of cytochrome b as a sensitive target for PCR based detection of T. annulata carrier animals. Veterinary Parasitology, 174(3-4), pp. 341-347. (doi:10.1016/j.vetpar.2010.08.025)

Chaussepied, M. et al. (2010) TGF-b2 induction regulates invasiveness of theileria-transformed leukocytes and disease susceptibility. PLoS Pathogens, 6(11), e1001197. (doi:10.1371/journal.ppat.1001197)

Weir, W., Karagenç, T., Baird, M., Tait, A., and Shiels, B.R. (2010) Evolution and diversity of secretome genes in the apicomplexan parasite Theileria annulata. BMC Genomics, 11, p. 42. (doi:10.1186/1471-2164-11-42)

2009

Weir, W., Sunter, J., Chaussepied, M., Skilton, R., Tait, A., de Villiers, E.P., Bishop, R., Shiels, B., and Langsley, G. (2009) Highly syntenic and yet divergent: a tale of two Theilerias. Infection, Genetics and Evolution, 9(4), pp. 453-461. (doi:10.1016/j.meegid.2009.01.002)

Beck, H.P. et al. (2009) Molecular approaches to diversity of populations of apicomplexan parasites. International Journal for Parasitology, 39(2), pp. 175-189. (doi:10.1016/j.ijpara.2008.10.001)

Sajid, M. et al. (2009) Proteases of parasitic protozoa - current status and validation. In: Selzer, P.M. (ed.) Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates. Series: Drug discovery in infectious diseases. Wiley-VCH: Weinheim, Germany, pp. 177-210. ISBN 9783527626823

2007

Weir, W., Ben-Miled, L., Karagenc, T., Katzer, F., Darghouth, M., Shiels, B., and Tait, A. (2007) Genetic exchange and sub-structuring in Theileria annulata populations. Molecular and Biochemical Parasitology, 154(2), pp. 170-180. (doi:10.1016/j.molbiopara.2007.04.015)

2006

Shiels, B., Langsley, G., Weir, W., Pain, A., McKellar, S., and Dobbelaere, D. (2006) Alteration of host cell phenotype by Theileria annulata and Theileria parva: mining for manipulators in the parasite genomes. International Journal for Parasitology, 36(1), pp. 9-21. (doi:10.1016/j.ijpara.2005.09.002)

2005

Oura, C.A.L., Asiimwe, B.B., Weir, W., Lubega, G.W., and Tait, A. (2005) Population genetic analysis and sub-structuring of Theileria parva in Uganda. Molecular and Biochemical Parasitology, 140(2), pp. 229-239. (doi:10.1016/j.molbiopara.2004.12.015)

Pain, A. et al. (2005) Genome of the host-cell transforming parasite Theileria annulata compared with T-parva. Science, 309, pp. 131-133. (doi:10.1126/science.1110418)

2003

Smith, H.V., Nichols, R.A.B., Weir, W., Mallon, M., Macleod, A., Wastling, J.M., Reilly, W.J., and Tait, A. (2003) Molecular investigations into waterborne outbreaks, incidents and events involving Cryptosporidium contamination. In: Latham, S.M., Smith, H.V. and Wastling, J.M. (eds.) Workshop on the Application of Genetic Fingerprinting for the Monitoring of Cryptosporidium in Humans, Animals and the Environment: Boulder, Colorado, USA, 3rd-5th August 2003. Foundation for Water Research (FWR): Marlow, Buckinghamshire, UK, pp. 85-90. ISBN 9780952171256

This list was generated on Sat Jun 25 20:11:55 2016 BST.
Number of items: 44.

Articles

Patakas, A., Ji, R.-R., Weir, W., Connolly, S. E., Benson, R. A., Nadler, S. G., McInnes, I. B., and Garside, P. (2016) Abatacept inhibition of T cell priming in mice by induction of a unique transcriptional profile that reduces their ability to activate antigen-presenting cells. Arthritis and Rheumatism, 68(3), pp. 627-638. (PMID:26473409)

Patakas, A., Ji, R., Weir, W., Connolly, S. E., Benson, R. A., Nadler, S. G., Brewer, J. M., McInnes, I. B., and Garside, P. (2016) Abatacept inhibits T cell priming by inducing of a unique transcriptional profile that reduces their ability to activate antigen presenting cells. Arthritis and Rheumatology, 68(3), pp. 627-638. (doi:10.1002/art.39470) (PMID:26473409)

Bilgic, H. B., Karagenc, T., Bakırc, S., Shiels, B., Tait, A., Kinnaird, J., Eren, H., and Weir, W. (2016) Identification and analysis of immunodominant antigens for ELISA-based detection of Theileria annulata. PLoS ONE, (Accepted for Publication)

Weir, W. et al. (2016) Population genomics reveals the origin and asexual evolution of human infective trypanosomes. eLife, 5, e11473. (doi:10.7554/eLife.11473) (PMID:26809473) (PMCID:PMC4739771)

Bishop, R.P., Hemmink, J.D., Morrison, W.I., Weir, W., Toye, P.G., Sitt, T., Spooner, P.R., Musoke, A.J., Skilton, R.A., and Odongo, D.O. (2015) The African buffalo parasite Theileria. sp. (buffalo) can infect and immortalize cattle leukocytes and encodes divergent orthologues of Theileria parva antigen genes. International Journal for Parasitology: Parasites and Wildlife, 4(3), pp. 333-342. (doi:10.1016/j.ijppaw.2015.08.006) (PMID:26543804) (PMCID:PMC4589832)

Pieszko, M., Weir, W., Goodhead, I., Kinnaird, J., and Shiels, B. (2015) ApiAP2 factors as candidate regulators of stochastic commitment to merozoite production in Theileria annulata. PLoS Neglected Tropical Diseases, 9(8), e0003933. (doi:10.1371/journal.pntd.0003933) (PMID:26273826) (PMCID:PMC4537280)

Capewell, P., Cooper, A., Clucas, C., Weir, W., and Macleod, A. (2015) A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome. Parasitology, 142(S1), S108-S119. (doi:10.1017/S0031182014000602) (PMID:25656360) (PMCID:PMC4413828)

Al-Hamidhi, S. et al. (2015) Genetic diversity and population structure of Theileria annulata in Oman. PLoS ONE, 10(10), e0139581. (doi:10.1371/journal.pone.0139581) (PMID:26469349) (PMCID:PMC4607491)

Capewell, P., Cooper, A., Clucas, C., Weir, W., Vaikkinen, H., Morrison, L., Tait, A., and MacLeod, A. (2015) Exploiting genetic variation to discover genes involved in important disease phenotypes. Methods in Molecular Biology, 1201, pp. 91-107. (doi:10.1007/978-1-4939-1438-8_5) (PMID:25388109)

Carletti, T., Barreto, C., Mesplet, M., Mira, A., Weir, W., Shiels, B., Oliva, A. G., Schnittger, L., and Florin-Christensen, M. (2015) Characterization of a papain-like cysteine protease essential for the survival of Babesia ovis merozoites. Ticks and Tick-borne Diseases, (doi:10.1016/j.ttbdis.2015.09.002) (PMID:26456355)

Winter, A. D. et al. (2015) A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites. BMC Genomics, 16, 331. (doi:10.1186/s12864-015-1536-y) (PMID:25896062) (PMCID:PMC4428239)

Woolhouse, M. E. J. et al. (2015) Co-infections determine patterns of mortality in a population exposed to parasite infection. Science Advances, 1(2), e1400026. (doi:10.1126/sciadv.1400026)

Jackson, A. P. et al. (2014) The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction. Nucleic Acids Research, 42(11), pp. 7113-7131. (doi:10.1093/nar/gku322) (PMID:24799432) (PMCID:PMC4066756)

Braceland, M., Bickerdike, R., Tinsley, J., Cockerill, D., Mcloughlin, M.F., Graham, D.A., Burchmore, R.J., Weir, W., Wallace, C., and Eckersall, P.D. (2013) The serum proteome of Atlantic salmon, Salmo salar, during pancreas disease (PD) following infection with salmonid alphavirus subtype 3 (SAV3). Journal of Proteomics, 94, pp. 423-436. (doi:10.1016/j.jprot.2013.10.016)

Asiimwe, B.B., Weir, W., Tait, A., Lubega, G.W., and Oura, C.A.L. (2013) Haemoparasite infection kinetics and the population structure of Theileria parva on a single farm in Uganda. Veterinary Parasitology, 193(1-3), pp. 8-14. (doi:10.1016/j.vetpar.2012.12.017)

Bilgiç, H. B., Karagenç, T., Simuunza, M., Shiels, B., Tait, A., Eren, H., and Weir, W. (2013) Development of a multiplex PCR assay for simultaneous detection of Theileria annulata, Babesia bovis and Anaplasma marginale in cattle. Experimental Parasitology, 133(2), pp. 222-229. (doi:10.1016/j.exppara.2012.11.005)

Capewell, P., Clucas, C., DeJesus, E., Kieft, R., Hajduk, S., Veitch, N., Steketee, P.C., Cooper, A., Weir, W., and MacLeod, A. (2013) The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense. PLoS Pathogens, 9(10), e1003686. (doi:10.1371/journal.ppat.1003686) (PMID:24098129) (PMCID:PMC3789759)

Hayashida, K., Abe, T., Weir, W., Nakao, R., Ito, K., Kajino, K., Suzuki, Y., Jongejan, F., Geysen, D., and Sugimoto, C. (2013) Whole-genome sequencing of Theileria parva strains provides insight into parasite migration and diversification in the african continent. DNA Research, 20(3), pp. 209-220. (doi:10.1093/dnares/dst003)

Kinnaird, J.H., Weir, W., Durrani, Z., Pillai, S.S., Baird, M., and Shiels, B.R. (2013) A bovine lymphosarcoma cell line infected with theileria annulata exhibits an irreversible reconfiguration of host cell gene expression. PLoS ONE, 8(6), e66833. (doi:10.1371/journal.pone.0066833)

Durrani, Z., Weir, W., Pillai, S., Kinnaird, J., and Shiels, B. (2012) Modulation of activation-associated host cell gene expression by the apicomplexan parasite Theileria annulata. Cellular Microbiology, 14(9), pp. 1434-1454. (doi:10.1111/j.1462-5822.2012.01809.x)

Hayashida, K. et al. (2012) Comparative genome analysis of three eukaryotic parasites with differing abilities to transform leukocytes reveals key mediators of Theileria-induced leukocyte transformation. MBIO, 3(5), e00204-12. (doi:10.1128/mBio.00204-12)

Winter, A.D., Weir, W., Hunt, M., Berriman, M., Gilleard, J.S., Devaney, E., and Britton, C. (2012) Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel. BMC Genomics, 13, p. 4. (doi:10.1186/1471-2164-13-4)

Oura, C.A.L., Tait, A., Asiimwe, B., Lubega, G.W., and Weir, W. (2011) Theileria parva genetic diversity and haemoparasite prevalence in cattle and wildlife in and around Lake Mburo National Park in Uganda. Parasitology Research, 108(6), pp. 1365-1374. (doi:10.1007/s00436-010-2030-8)

Simuunza, M., Bilgic, H., Karagenc, T., Syakalima, M., Shiels, B., Tait, A., and Weir, W. (2011) Population genetic analysis and sub-structuring in Babesia bovis. Molecular and Biochemical Parasitology, 177(2), pp. 106-115. (doi:10.1016/j.molbiopara.2011.02.002)

Connelley, T.K., MacHugh, N.D., Pelle, R., Weir, W., and Morrison, W.I. (2011) Escape from CD8+ T cell response by natural variants of an immunodominant epitope from Theileria parva is predominantly due to loss of TCR recognition. Journal of Immunology, 187(11), pp. 5910-5920. (doi:10.4049/jimmunol.1102009)

Gharbi, M. et al. (2011) Prime-boost immunisation against tropical theileriosis with two parasite surface antigens: Evidence for protection and antigen synergy. Vaccine, 29(38), pp. 6620-6628. (doi:10.1016/j.vaccine.2011.06.109)

MacHugh, N. D., Weir, W., Burrells, A., Lizundia, R., Graham, S.P., Taracha, E.L., Shiels, B.R., Langsley, G., and Morrison, W.I. (2011) Extensive polymorphism and evidence of immune selection in a highly dominant antigen recognized by bovine CD8 T cells specific for Theileria annulata. Infection and Immunity, 79(5), pp. 2059-2069. (doi:10.1128/IAI.01285-10)

Oura, C.A.L., Tait, A., Asiimwe, B., Lubega, G.W., and Weir, W. (2011) Haemoparasite prevalence and Theileria parva strain diversity in Cape buffalo (Syncerus caffer) in Uganda. Veterinary Parasitology, 175(3-4), pp. 212-219. (doi:10.1016/j.vetpar.2010.10.032)

Pelle, R. et al. (2011) Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity. PLoS ONE, 6(4), e19015. (doi:10.1371/journal.pone.0019015)

Simuunza, M., Weir, W., Courcier, E., Tait, A., and Shiels, B. (2011) Epidemiological analysis of tick-borne diseases in Zambia. Veterinary Parasitology, 175(3-4), pp. 331-342. (doi:10.1016/j.vetpar.2010.09.027)

Weir, W., Karagenç, T., Gharbi, M., Simuunza, M., Aypak, S., Aysul, N., Darghouth, M. A., Shiels, B., and Tait, A. (2011) Population diversity and multiplicity of infection in Theileria annulata. International Journal for Parasitology, 41(2), pp. 193-203. (doi:10.1016/j.ijpara.2010.08.004)

Schmuckli-Maurer, J., Kinnaird, J., Pillai, S., Hermann, P., McKellar, S., Weir, W., Dobbelaere, D., and Shiels, B. (2010) Modulation of NF-kappaB activation in Theileria annulata-infected cloned cell lines is associated with detection of parasite-dependent IKK signalosomes and disruption of the actin cytoskeleton. Cellular Microbiology, 12(2), pp. 158-173. (doi:10.1111/j.1462-5822.2009.01386.x)

Bilgic, H.B., Karagenç, T., Shiels, B., Tait, A., Eren, H., and Weir, W. (2010) Evaluation of cytochrome b as a sensitive target for PCR based detection of T. annulata carrier animals. Veterinary Parasitology, 174(3-4), pp. 341-347. (doi:10.1016/j.vetpar.2010.08.025)

Chaussepied, M. et al. (2010) TGF-b2 induction regulates invasiveness of theileria-transformed leukocytes and disease susceptibility. PLoS Pathogens, 6(11), e1001197. (doi:10.1371/journal.ppat.1001197)

Weir, W., Karagenç, T., Baird, M., Tait, A., and Shiels, B.R. (2010) Evolution and diversity of secretome genes in the apicomplexan parasite Theileria annulata. BMC Genomics, 11, p. 42. (doi:10.1186/1471-2164-11-42)

Weir, W., Sunter, J., Chaussepied, M., Skilton, R., Tait, A., de Villiers, E.P., Bishop, R., Shiels, B., and Langsley, G. (2009) Highly syntenic and yet divergent: a tale of two Theilerias. Infection, Genetics and Evolution, 9(4), pp. 453-461. (doi:10.1016/j.meegid.2009.01.002)

Beck, H.P. et al. (2009) Molecular approaches to diversity of populations of apicomplexan parasites. International Journal for Parasitology, 39(2), pp. 175-189. (doi:10.1016/j.ijpara.2008.10.001)

Weir, W., Ben-Miled, L., Karagenc, T., Katzer, F., Darghouth, M., Shiels, B., and Tait, A. (2007) Genetic exchange and sub-structuring in Theileria annulata populations. Molecular and Biochemical Parasitology, 154(2), pp. 170-180. (doi:10.1016/j.molbiopara.2007.04.015)

Shiels, B., Langsley, G., Weir, W., Pain, A., McKellar, S., and Dobbelaere, D. (2006) Alteration of host cell phenotype by Theileria annulata and Theileria parva: mining for manipulators in the parasite genomes. International Journal for Parasitology, 36(1), pp. 9-21. (doi:10.1016/j.ijpara.2005.09.002)

Oura, C.A.L., Asiimwe, B.B., Weir, W., Lubega, G.W., and Tait, A. (2005) Population genetic analysis and sub-structuring of Theileria parva in Uganda. Molecular and Biochemical Parasitology, 140(2), pp. 229-239. (doi:10.1016/j.molbiopara.2004.12.015)

Pain, A. et al. (2005) Genome of the host-cell transforming parasite Theileria annulata compared with T-parva. Science, 309, pp. 131-133. (doi:10.1126/science.1110418)

Book Sections

Capewell, P., Clucas, C., Weir, W., Veitch, N., and MacLeod, A. (2013) Normal human serum lysis of non-human trypanosomes and resistance of T. b. rhodesiense and T. b. gambiense. In: Magez, S. and Radwanska, M. (eds.) Trypanosomes and Trypanosomiasis. Springer, pp. 139-160. ISBN 9783709115558 (doi:10.1007/978-3-7091-1556-5_6)

Sajid, M. et al. (2009) Proteases of parasitic protozoa - current status and validation. In: Selzer, P.M. (ed.) Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates. Series: Drug discovery in infectious diseases. Wiley-VCH: Weinheim, Germany, pp. 177-210. ISBN 9783527626823

Smith, H.V., Nichols, R.A.B., Weir, W., Mallon, M., Macleod, A., Wastling, J.M., Reilly, W.J., and Tait, A. (2003) Molecular investigations into waterborne outbreaks, incidents and events involving Cryptosporidium contamination. In: Latham, S.M., Smith, H.V. and Wastling, J.M. (eds.) Workshop on the Application of Genetic Fingerprinting for the Monitoring of Cryptosporidium in Humans, Animals and the Environment: Boulder, Colorado, USA, 3rd-5th August 2003. Foundation for Water Research (FWR): Marlow, Buckinghamshire, UK, pp. 85-90. ISBN 9780952171256

This list was generated on Sat Jun 25 20:11:55 2016 BST.