2024

Ungogo, M. A. and de Koning, H. P. (2024) Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies. International Journal for Parasitology: Drugs and Drug Resistance, 25, 100533. (doi: 10.1016/j.ijpddr.2024.100533) (PMID:38555795) (PMCID:PMC10990905)

2023

Ungogo, M. A. et al. (2023) Cloning and characterization of Trypanosoma congolense and T. vivax nucleoside transporters reveal the potential of P1-type carriers for the discovery of broad-spectrum nucleoside-based therapeutics against Animal African Trypanosomiasis. International Journal of Molecular Sciences, 24(4), 3144. (doi: 10.3390/ijms24043144) (PMID:36834557) (PMCID:PMC9960827)

2022

Mabille, D., Ilbeigi, K., Hendrickx, S., Ungogo, M. A., Hulpia, F., Lin, C., Maes, L., de Koning, H. P. , Van Calenbergh, S. and Caljon, G. (2022) Nucleoside analogues for the treatment of animal trypanosomiasis. International Journal for Parasitology: Drugs and Drug Resistance, 19, pp. 21-30. (doi: 10.1016/j.ijpddr.2022.05.001) (PMID:35567803) (PMCID:PMC9111543)

Alenezi, S. S. et al. (2022) The antiprotozoal activity of Papua New Guinea propolis and its triterpenes. Molecules, 27(5), 1622. (doi: 10.3390/molecules27051622) (PMID:35268726) (PMCID:PMC8911803)

Ungogo, M. A., Campagnaro, G. D., Alghamdi, A. H., Natto, M. J. and de Koning, H. P. (2022) Differences in transporters rather than drug targets are the principal determinants of the different innate sensitivities of Trypanosoma congolense and Trypanozoon subgenus trypanosomes to diamidines and melaminophenyl arsenicals. International Journal of Molecular Sciences, 23(5), 2844. (doi: 10.3390/ijms23052844) (PMID:35269985) (PMCID:PMC8911344)

Cisneros, D. et al. (2022) Imidazoline- and benzamidine-based trypanosome alternative oxidase inhibitors: synthesis and structure–activity relationship studies. ACS Medicinal Chemistry Letters, 13(2), pp. 312-318. (doi: 10.1021/acsmedchemlett.1c00717) (PMID:35178188) (PMCID:PMC8842630)

Bala, A. A. et al. (2022) Preclinical efficacy of African medicinal plants used in the treatment of snakebite envenoming: a systematic review protocol. Therapeutic Advances in Infectious Disease, 9, p. 20499361211072644. (doi: 10.1177/20499361211072644) (PMID:35237433) (PMCID:PMC8882943)

2021

Burley, G., Watson, A. J. B., de Koning, H. , Jones, K., Robertson, J., Bode, B., McWhinnie, F., Ungogo, M., Aldfer, M. and Lemgruber Soares, L. (2021) Direct, late‐stage mono‐N‐arylation of pentamidine: method development, mechanistic insights, and expedient access to novel antiparastitics against diamidine‐resistant parasites. ChemMedChem, 16(22), pp. 3396-3401. (doi: 10.1002/cmdc.202100509) (PMID:34357687)

Cueto-Díaz, E. J. et al. (2021) Synthesis, biological, and photophysical studies of molecular rotor-based fluorescent inhibitors of the Trypanosome Alternative Oxidase. European Journal of Medicinal Chemistry, 2020, 113470. (doi: 10.1016/j.ejmech.2021.113470) (PMID:33940464)

Carruthers, L. V. et al. (2021) Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential. Molecular Microbiology, 116(2), pp. 564-588. (doi: 10.1111/mmi.14733) (PMID:33932053)

Anyam, J. V., Daikwo, P. E., Ungogo, M. A., Nweze, N. E., Igoli, N. P., Gray, A. I., De Koning, H. P. and Igoli, J. O. (2021) Two new antiprotozoal diterpenes from the roots of Acacia nilotica. Frontiers in Chemistry, 9, 624741. (doi: 10.3389/fchem.2021.624741) (PMID:33968894) (PMCID:PMC8097170)

2020

Ungogo, M. A., Ebiloma, G. U., Ichoron, N., Igoli, J. O., De Koning, H. P. and Balogun, E. O. (2020) A review of the antimalarial, antitrypanosomal, and antileishmanial activities of natural compounds isolated from Nigerian flora. Frontiers in Chemistry, 8, 617448. (doi: 10.3389/fchem.2020.617448) (PMID:33425860) (PMCID:PMC7786139)

Nvau, J. B., Alenezi, S., Ungogo, M. A., Alfayez, I. A.M., Natto, M. J., Gray, A. I., Ferro, V. A., Watson, D. G., De Koning, H. P. and Igoli, J. O. (2020) Antiparasitic and cytotoxic activity of bokkosin, a novel diterpene-substituted chromanyl benzoquinone from Calliandra portoricensis. Frontiers in Chemistry, 8, p. 574103. (doi: 10.3389/fchem.2020.574103) (PMID:33282826) (PMCID:PMC7705231)

Hulpia, F., Campagnaro, G. D., Alzahrani, K. J., Alfayez, I. A., Ungogo, M. A., Mabille, D., Maes, L., de Koning, H. P. , Caljon, G. and Van Calenbergh, S. (2020) Structure–activity relationship exploration of 3′-deoxy-7-deazapurine nucleoside analogues as anti-Trypanosoma brucei agents. ACS Infectious Diseases, 6(8), pp. 2045-2056. (doi: 10.1021/acsinfecdis.0c00105) (PMID:32568511)

Articles

Ungogo, M. A. and de Koning, H. P. (2024) Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies. International Journal for Parasitology: Drugs and Drug Resistance, 25, 100533. (doi: 10.1016/j.ijpddr.2024.100533) (PMID:38555795) (PMCID:PMC10990905)

Ungogo, M. A. et al. (2023) Cloning and characterization of Trypanosoma congolense and T. vivax nucleoside transporters reveal the potential of P1-type carriers for the discovery of broad-spectrum nucleoside-based therapeutics against Animal African Trypanosomiasis. International Journal of Molecular Sciences, 24(4), 3144. (doi: 10.3390/ijms24043144) (PMID:36834557) (PMCID:PMC9960827)

Mabille, D., Ilbeigi, K., Hendrickx, S., Ungogo, M. A., Hulpia, F., Lin, C., Maes, L., de Koning, H. P. , Van Calenbergh, S. and Caljon, G. (2022) Nucleoside analogues for the treatment of animal trypanosomiasis. International Journal for Parasitology: Drugs and Drug Resistance, 19, pp. 21-30. (doi: 10.1016/j.ijpddr.2022.05.001) (PMID:35567803) (PMCID:PMC9111543)

Alenezi, S. S. et al. (2022) The antiprotozoal activity of Papua New Guinea propolis and its triterpenes. Molecules, 27(5), 1622. (doi: 10.3390/molecules27051622) (PMID:35268726) (PMCID:PMC8911803)

Ungogo, M. A., Campagnaro, G. D., Alghamdi, A. H., Natto, M. J. and de Koning, H. P. (2022) Differences in transporters rather than drug targets are the principal determinants of the different innate sensitivities of Trypanosoma congolense and Trypanozoon subgenus trypanosomes to diamidines and melaminophenyl arsenicals. International Journal of Molecular Sciences, 23(5), 2844. (doi: 10.3390/ijms23052844) (PMID:35269985) (PMCID:PMC8911344)

Cisneros, D. et al. (2022) Imidazoline- and benzamidine-based trypanosome alternative oxidase inhibitors: synthesis and structure–activity relationship studies. ACS Medicinal Chemistry Letters, 13(2), pp. 312-318. (doi: 10.1021/acsmedchemlett.1c00717) (PMID:35178188) (PMCID:PMC8842630)

Bala, A. A. et al. (2022) Preclinical efficacy of African medicinal plants used in the treatment of snakebite envenoming: a systematic review protocol. Therapeutic Advances in Infectious Disease, 9, p. 20499361211072644. (doi: 10.1177/20499361211072644) (PMID:35237433) (PMCID:PMC8882943)

Burley, G., Watson, A. J. B., de Koning, H. , Jones, K., Robertson, J., Bode, B., McWhinnie, F., Ungogo, M., Aldfer, M. and Lemgruber Soares, L. (2021) Direct, late‐stage mono‐N‐arylation of pentamidine: method development, mechanistic insights, and expedient access to novel antiparastitics against diamidine‐resistant parasites. ChemMedChem, 16(22), pp. 3396-3401. (doi: 10.1002/cmdc.202100509) (PMID:34357687)

Cueto-Díaz, E. J. et al. (2021) Synthesis, biological, and photophysical studies of molecular rotor-based fluorescent inhibitors of the Trypanosome Alternative Oxidase. European Journal of Medicinal Chemistry, 2020, 113470. (doi: 10.1016/j.ejmech.2021.113470) (PMID:33940464)

Carruthers, L. V. et al. (2021) Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential. Molecular Microbiology, 116(2), pp. 564-588. (doi: 10.1111/mmi.14733) (PMID:33932053)

Anyam, J. V., Daikwo, P. E., Ungogo, M. A., Nweze, N. E., Igoli, N. P., Gray, A. I., De Koning, H. P. and Igoli, J. O. (2021) Two new antiprotozoal diterpenes from the roots of Acacia nilotica. Frontiers in Chemistry, 9, 624741. (doi: 10.3389/fchem.2021.624741) (PMID:33968894) (PMCID:PMC8097170)

Ungogo, M. A., Ebiloma, G. U., Ichoron, N., Igoli, J. O., De Koning, H. P. and Balogun, E. O. (2020) A review of the antimalarial, antitrypanosomal, and antileishmanial activities of natural compounds isolated from Nigerian flora. Frontiers in Chemistry, 8, 617448. (doi: 10.3389/fchem.2020.617448) (PMID:33425860) (PMCID:PMC7786139)

Nvau, J. B., Alenezi, S., Ungogo, M. A., Alfayez, I. A.M., Natto, M. J., Gray, A. I., Ferro, V. A., Watson, D. G., De Koning, H. P. and Igoli, J. O. (2020) Antiparasitic and cytotoxic activity of bokkosin, a novel diterpene-substituted chromanyl benzoquinone from Calliandra portoricensis. Frontiers in Chemistry, 8, p. 574103. (doi: 10.3389/fchem.2020.574103) (PMID:33282826) (PMCID:PMC7705231)

Hulpia, F., Campagnaro, G. D., Alzahrani, K. J., Alfayez, I. A., Ungogo, M. A., Mabille, D., Maes, L., de Koning, H. P. , Caljon, G. and Van Calenbergh, S. (2020) Structure–activity relationship exploration of 3′-deoxy-7-deazapurine nucleoside analogues as anti-Trypanosoma brucei agents. ACS Infectious Diseases, 6(8), pp. 2045-2056. (doi: 10.1021/acsinfecdis.0c00105) (PMID:32568511)