Professor Simon Kennedy

  • Professor of Vascular Pharmacology (Cardiovascular & Metabolic Health)
  • Elected Academic Staff Member on Court and Senior Senate Assessor for Student Conduct, Elected Academic Staff Member on Court (Student Conduct) (Academic Services)

telephone: 01413304763
email: Simon.Kennedy@glasgow.ac.uk

R415 Level 4, Institute of C&MS, Sir James Black Building, Glasgow G12 8QQ

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-0887-5840

Biography

Professor Simon Kennedy joined the University of Glasgow in 2006, initially within the Institute of Cardiovascular & Medical Sciences and latterly within the School of Life Sciences.

From a research and teaching role, Professor Kennedy moved to a more teaching-focussed role whilst still collaborating on research projects with colleagues within ICAMS, College of Science and Engineering and external partners.

He co-ordinates Level 4 of the Pharmacology degree as well as three final-year options, one of which teaches in vivo skills to undergraduate students and is funded by a teaching grant from the British Pharmacological Society.

A member of the College Appeals panel and deputy Postgraduate Convenor for School of Life Sciences, he teaches at all levels on degrees within the School, as well as on the MBChB and BDS degrees and acts as an advisor of studies to around 40 undergraduate students.

At University level, Professor Kennedy serves as the Senior Senate Assessor for Student Conduct, is one of the elected Senate Asessors on the University Court, and sits on the the Education Policy & Strategy Committee, Finance Committee, Audit and Risk Committee, and the Glasgow University Sports Association (GUSA) Committee.

An active member of the British Pharmacological Society, he serves on their Finance Committee and their awards committee, as well as being both an 'Educator Expert' on their Ambassador Scheme to promote the in vivo undergraduate curriculum and a member of the Education and Training Committee.

Other external academic associations include being part of the editorial board of two top-ranking pharmacology journals, an external examiner at two Russell Group universities, and treasurer of the Scottish Cardiovascular Forum.

Research interests

Research Theme: Vascular Diseases and Comorbidities

Perivascular adipose tissue (PVAT) and the control of vascular function with a particular emphasis on the effects of an enzyme known as AMPK within the PVAT and the vascular wall.

The effects of hypoxia on the expression and function of an enzyme known as Sphingosine Kinase (SK) and how this modulates vascular function.

The role of Connexins which allow communication between cells and how this affects vascular function within the pulmonary and systemic circulations.

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2004 | 2003 | 2001 | 2000 | 1998 | 1997
Number of items: 73.

2024

Ramses, R., Kennedy, S. , Good, R., Oldroyd, K. G. and Mcginty, S. (2024) Performance of drug-coated balloons in coronary and below-the-knee arteries: anatomical, physiological and pathological considerations. Vascular Pharmacology, 155, 107366. (doi: 10.1016/j.vph.2024.107366) (PMID:38479462)

Hoare, D., Kingsmore, D., Holsgrove, M., Russell, E., Kirimi, M. T., Czyzewski, J., Mirzai, N., Kennedy, S. , Neale, S. L. and Mercer, J. R. (2024) Realtime monitoring of thrombus formation in vivo using a self-reporting vascular access graft. Communications Medicine, 4, 15. (doi: 10.1038/s43856-024-00436-8) (PMID:38316912) (PMCID:PMC10844314)

2023

Lyon, M., Fullerton, J. L. , Kennedy, S. and Work, L. M. (2023) Hypertension & dementia: pathophysiology & potential utility of antihypertensives in reducing disease burden. Pharmacology and Therapeutics, (doi: 10.1016/j.pharmthera.2023.108575) (PMID:38052309) (In Press)

2022

McQueen, A., Escuer, J., Schmidt, A. F., Aggarwal, A. , Kennedy, S. , McCormick, C., Oldroyd, K. and Mcginty, S. (2022) An intricate interplay between stent drug dose and release rate dictates arterial restenosis. Journal of Controlled Release, 349, pp. 992-1008. (doi: 10.1016/j.jconrel.2022.07.037) (PMID:35921913)

2021

McQueen, A., Escuer, J., Aggarwal, A. , Kennedy, S. , McCormick, C., Oldroyd, K. and Mcginty, S. (2021) Do we really understand how drug eluted from stents modulates arterial healing? International Journal of Pharmaceutics, 601, 120575. (doi: 10.1016/j.ijpharm.2021.120575) (PMID:33845150)

2020

Abdulqader, A. and Kennedy, S. (2020) The influence of perivascular adipose tissue on vascular function in a rabbit model. Pharmacology and Pharmacy, 11, pp. 331-349. (doi: 10.4236/pp.2020.1112027)

McQueen, A., Kennedy, S. , McCormick, C., Aggarwal, A. and McGinty, S. (2020) Mathematical Modelling of the Effect of Drug on Smooth Muscle Cell Proliferation. Scottish Cardiovascular Forum 2020, 23rd Annual Meeting, Glasgow, UK, 1 Feb 2020.

2019

Alganga, H. S. F., Almabrouk, T. A.M. , Katwan, O. J., Daly, C. J. , Pyne, S., Pyne, N. J. and Kennedy, S. (2019) Short periods of hypoxia upregulate sphingosine kinase 1 and increase vasodilation of arteries to Sphingosine 1-phosphate via S1P3. Journal of Pharmacology and Experimental Therapeutics, 371(1), pp. 63-74. (doi: 10.1124/jpet.119.257931) (PMID:31371480)

Katwan, O. J., Alghamdi, F., Almabrouk, T. A. , Mancini, S. J., Kennedy, S. , Oakhill, J. S., Scott, J. W. and Salt, I. P. (2019) AMP-activated protein kinase complexes containing the β2 regulatory subunit are upregulated during and contribute to adipogenesis. Biochemical Journal, 476(12), pp. 1725-1740. (doi: 10.1042/BCJ20180714) (PMID:31189568) (PMCID:PMC6595317)

McKittrick, C., McKee, S., Kennedy, S. , Oldroyd, K., Wheel, M., Pontrelli, G., Dixon, S., Mcginty, S. and McCormick, C. (2019) Combining mathematical modelling with in vitro experiments to predict in vivo drug-eluting stent performance. Journal of Controlled Release, 303, pp. 151-161. (doi: 10.1016/j.jconrel.2019.03.012) (PMID:30878363)

Ugusman, A. B., Riddell, A. and Kennedy, S. (2019) Effect of peroxynitrite (ONOO−) on the function of murine perivascular adipose tissue. Pharmacology and Pharmacy, 10(4), pp. 194-204. (doi: 10.4236/pp.2019.104017)

Greig, F. H. et al. (2019) Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse. European Journal of Pharmacology, 842, pp. 1-9. (doi: 10.1016/j.ejphar.2018.10.027) (PMID:30359564) (PMCID:PMC6318480)

Kennedy, S. and Touyz, R. M. (2019) Anatomy and pharmacology of vessels. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 3-11. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_1)

2018

Mancini, S. J., Boyd, D., Katwan, O. J., Strembitska, A., Almabrouk, T. A., Kennedy, S. , Palmer, T. M. and Salt, I. P. (2018) Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms. Scientific Reports, 8, 5276. (doi: 10.1038/s41598-018-23420-4) (PMID:29588466) (PMCID:PMC5869674)

Almabrouk, T. A.M. , White, A. D., Ugusman, A. B., Skiba, D. S., Katwan, O. J., Alganga, H., Guzik, T. J., Touyz, R. M. , Salt, I. P. and Kennedy, S. (2018) High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion. Frontiers in Physiology, 9, 51. (doi: 10.3389/fphys.2018.00051) (PMID:29479319) (PMCID:PMC5812172)

2017

Almabrouk, T. A. M. , Ugusman, A. B., Katwan, O. J., Salt, I. P. and Kennedy, S. (2017) Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release. British Journal of Pharmacology, 174(20), pp. 3398-3410. (doi: 10.1111/bph.13633) (PMID:27668984)

Kennedy, S. and Salt, I. P. (2017) Molecular mechanisms regulating perivascular adipose tissue - potential pharmacological targets? British Journal of Pharmacology, 174(20), pp. 3385-3387. (doi: 10.1111/bph.13969) (PMID:28940457)

Wu, J., Lawrence, C., Wadsworth, R. M. and Kennedy, S. (2017) Perivascular mast cells promote neointimal elastin deposition and suppress chronic vein graft restenosis in hyperlipidaemic mice. Vessel Plus, 2017(1), pp. 137-144. (doi: 10.20517/2574-1209.2017.15)

Greig, F. H., Kennedy, S. , Gibson, G., Ramos, J. W. and Nixon, G. F. (2017) PEA-15 (phosphoprotein enriched in astrocytes 15) is a protective mediator in the vasculature and is regulated during neointimal hyperplasia. Journal of the American Heart Association, 6(9), e006936. (doi: 10.1161/JAHA.117.006936) (PMID:28893763) (PMCID:PMC5634313)

Ewart, M.-A., Ugusman, A., Vishwanath, A., Almabrouk, T. A.M., Alganga, H. S.F., Katwan, O. J., Hubanova, P., Currie, S. and Kennedy, S. (2017) Changes in IP3 receptor expression and function in aortic smooth muscle of atherosclerotic mice. Journal of Vascular Research, 54(2), pp. 68-78. (doi: 10.1159/000461581) (PMID:28365690) (PMCID:PMC5804831)

Houston, S. A., Ugusman, A., Gnanadesika, S. and Kennedy, S. (2017) An investigation of the antiplatelet effects of succinobucol (AGI-1067). Platelets, 28(3), pp. 295-300. (doi: 10.1080/09537104.2016.1218456) (PMID:27681689)

McGinty, S. , McCormick, C., McKittrick, C., Kennedy, S. , Oldroyd, K., Wheel, M., Scullion, B., Pontrelli, G. and McKee, S. (2017) Combining Mathematical Modelling with In-Vitro Experiments to Predict In-Vivo Drug-Eluting Stent Kinetics. In: 5 th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017), Pittsburgh, PA, USA, 10-12 April 2017, pp. 1011-1014. ISBN 9780956291448

2016

MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S. , Pyne, S. and Pyne, N. J. (2016) Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cellular Signalling, 28(8), pp. 946-955. (doi: 10.1016/j.cellsig.2016.03.014) (PMID:27063355) (PMCID:PMC4913619)

McCormick, C., Jones, R. L., Wadsworth, R. M., Mullen, A. B. and Kennedy, S. (2016) A polymer coated cicaprost-eluting stent increases neointima formation and impairs vessel function in the rabbit iliac artery. Pharmacology and Pharmacy, 7(6), pp. 226-235. (doi: 10.4236/pp.2016.76029)

McKittrick, C.M., Kennedy, S. , Oldroyd, K.G., Mcginty, S. and McCormick, C. (2016) Modelling the impact of atherosclerosis on drug release and distribution from coronary stents. Annals of Biomedical Engineering, 44(2), pp. 477-487. (doi: 10.1007/s10439-015-1456-7) (PMID:26384667) (PMCID:PMC4764635)

Watt, J., Kennedy, S. , Ahmed, N., Hayhurst, J., McClure, J. D. , Berry, C. , Wadsworth, R. M. and Oldroyd, K. G. (2016) The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD. Open Heart, 3(1), e000342. (doi: 10.1136/openhrt-2015-000342) (PMID:26848395) (PMCID:PMC4731840)

2015

Greig, F. H., Ewart, M.-A., McNaughton, E., Cooney, J., Spickett, C. M. and Kennedy, S. (2015) The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice. Vascular Pharmacology, 74, pp. 93-102. (doi: 10.1016/j.vph.2015.07.010) (PMID:26196300) (PMCID:PMC4673085)

Wu, J., Grassia, G., Cambrook, H., Ialenti, A., MacRitchie, N., Carberry, J., Wadsworth, R. M., Lawrence, C., Kennedy, S. and Maffia, P. (2015) Perivascular mast cells regulate vein graft neointimal formation and remodeling. PeerJ, 3, e1192. (doi: 10.7717/peerj.1192) (PMID:26312183) (PMCID:PMC4548472)

Mckinney, C.A., Kennedy, S. , Baillie, G.S. , Milligan, G. and Nicklin, S.A. (2015) Angiotensin-(1-7) and angiotensin-(1-9) inhibit vascular smooth muscle cell growth and migration in vitro and vascular remodelling in vivo. Atherosclerosis, 241(1), e44. (doi: 10.1016/j.atherosclerosis.2015.04.158)

McDonald, R. A. et al. (2015) Reducing in-stent restenosis therapeutic manipulation of miRNA in vascular remodeling and inflammation. Journal of the American College of Cardiology, 65(21), pp. 2314-2327. (doi: 10.1016/j.jacc.2015.03.549) (PMID:26022821) (PMCID:PMC4444526)

Greig, F. H., Hutchison, L., Spickett, C. M. and Kennedy, S. (2015) Differential effects of chlorinated and oxidized phospholipids in vascular tissue: implications for neointima formation. Clinical Science, 128, pp. 579-592. (doi: 10.1042/CS20140578) (PMID:25524654)

McGinty, S. , Wheel, M., McKee, S., McCormick, C., McKittrick, C., Kennedy, S. and Oldroyd, K. (2015) Can Anisotropy Enhance the Spatial Uniformity of Drug Distribution in Biological Tissue? In: 4th International Conference on Computational & Mathematical Biomedical Engineering, Paris, France, 29 June - 1 July 2015, pp. 194-197. ISBN 9780956291431

2014

Farmer, D. G.S., Ewart, M.-A., Mair, K. M. and Kennedy, S. (2014) Soluble receptor for advanced glycation end products (sRAGE) attenuates haemodynamic changes to chronic hypoxia in the mouse. Pulmonary Pharmacology and Therapeutics, 29(1), pp. 7-14. (doi: 10.1016/j.pupt.2014.01.002)

Ewart, M.-A., Kennedy, S. , MacMillan, D., Raja, A. L.N., Watt, I. M. and Currie, S. (2014) Altered vascular smooth muscle function in the ApoE knockout mouse during the progression of atherosclerosis. Atherosclerosis, 234(1), pp. 154-161. (doi: 10.1016/j.atherosclerosis.2014.02.014)

Almabrouk, T.A.M. , Ewart, M.-A., Salt, I.P. and Kennedy, S. (2014) Perivascular fat, AMP-activated protein kinase and vascular diseases. British Journal of Pharmacology, 171(3), pp. 595-617. (doi: 10.1111/bph.12479) (PMID:24490856) (PMCID:PMC3969075)

2013

McDonald, R. A. et al. (2013) miRNA-21 is dysregulated in response to vein grafting in multiple models and genetic ablation in mice attenuates neointima formation. European Heart Journal, 34(22), pp. 1636-1643. (doi: 10.1093/eurheartj/eht105)

Kennedy, S. , Wu, J., Wadsworth, R.M., Lawrence, C.E. and Maffia, P. (2013) Mast cells and vascular diseases. Pharmacology and Therapeutics, 138(1), pp. 53-65. (doi: 10.1016/j.pharmthera.2013.01.001)

Watt, J., Kennedy, S. , McCormick, C., Agbani, E.O., McPhaden, A., Mullen, A., Czudaj, P., Behnisch, B., Wadsworth, R.M. and Oldroyd, K.G. (2013) Succinobucol-eluting stents increase neointimal thickening and peri-strut inflammation in a porcine coronary model. Catheterization and Cardiovascular Interventions, 81(4), pp. 698-708. (doi: 10.1002/ccd.24473)

2012

Ewart, M.-A. and Kennedy, S. (2012) Diabetic cardiovascular disease AMP-activated protein kinase (AMPK) as a therapeutic target. Cardiovascular and Hematological Agents in Medicinal Chemistry, 10(3), pp. 190-211. (doi: 10.2174/187152512802651015)

Watt, J., Ewart, M.-A., Greig, F. H., Oldroyd, K. G., Wadsworth, R. M. and Kennedy, S. (2012) The effect of reactive oxygen species on whole blood aggregation and the endothelial cell-platelet interaction in patients with coronary heart disease. Thrombosis Research, 130(2), pp. 210-215. (doi: 10.1016/j.thromres.2012.03.024)

Greig, F. H., Kennedy, S. and Spickett, C. M. (2012) Physiological effects of oxidized phospholipids and their cellular signaling mechanisms in inflammation. Free Radical Biology and Medicine, 52(2), pp. 266-280. (doi: 10.1016/j.freeradbiomed.2011.10.481)

Watt, J., Ewart, M.-A., Greig, F.H., Oldroyd, K.G., Wadsworth, R.M. and Kennedy, S. (2012) The effect of reactive oxygen species on whole blood aggregation and the enothelial cell-platelet interaction in patients with coronary heart disease. Thrombosis Research, 130(2), pp. 210-215. (doi: 10.1016/j.thromres.2012.03.024)

2011

Ialenti, A. et al. (2011) Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(11), pp. 2448-2454. (doi: 10.1161/ATVBAHA.111.230078) (PMID:21852559)

Ewart, M.-A. and Kennedy, S. (2011) AMPK and vasculoprotection. Pharmacology and Therapeutics, 131(2), pp. 242-253. (doi: 10.1016/j.pharmthera.2010.11.002)

Wu, J., Wadsworth, R.M. and Kennedy, S. (2011) Inhibition of inducible Nitric Oxide synthase promotes vein graft neoadventitial inflammation and remodelling. Journal of Vascular Research, 48(2), pp. 141-149. (doi: 10.1159/000316968)

2010

Grassia, G. et al. (2010) The IkB kinase inhibitor nuclear factor-kB essential modulator–binding domain peptide for inhibition of balloon injury-induced neointimal formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(12), pp. 2458-2466. (doi: 10.1161/ATVBAHA.110.215467) (PMID:20930169)

Guglielmotti, A., Grassia, G., Gordon, P., Maddaluno, M., Di Lauro, M.V., Biondi, G., Colombo, A., Ialenti, A., Maffia, P. and Kennedy, S. (2010) Bindarit, an inhibitor of monocyte chemoattractant proteins (MCPs) production, reduces in-stent restenosis in porcine coronary arteries. In: American Heart Association Scientific Session 2010, Chicago, IL, 13-17 Nov 2010, A11429.

Shedden, L., Kennedy, S. , Wadsworth, R. and Connolly, P. (2010) Towards a self-reporting coronary artery stent—Measuring neointimal growth associated with in-stent restenosis using electrical impedance techniques. Biosensors and Bioelectronics, 26(2), pp. 661-666. (doi: 10.1016/j.bios.2010.06.073) (PMID:20667708)

McCormick, C., Jones, R.L., Kennedy, S. and Wadsworth, R.M. (2010) Activation of prostanoid EP receptors by prostacyclin analogues in rabbit iliac artery: Implications for anti-restenotic potential. European Journal of Pharmacology, 641(2-3), pp. 160-167. (doi: 10.1016/j.ejphar.2010.04.035)

Mair, K.M., Robinson, E., Kane, K.A., Pyne, S., Brett, R.R., Pyne, N.J. and Kennedy, S. (2010) Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. British Journal of Pharmacology, 161(1), pp. 176-192. (doi: 10.1111/j.1476-5381.2010.00878.x)

2009

Lim, S.Y., Wainwright, C.L., Kennedy, S. and Kane, K.A. (2009) Activation of protease activated receptor-2 induces delayed cardioprotection in anesthetized mice. Cardiovascular Drugs and Therapy, 23(6), pp. 519-520. (doi: 10.1007/s10557-007-6073-8)

Farmer, D.G.S. and Kennedy, S. (2009) RAGE, vascular tone and vascular disease. Pharmacology and Therapeutics, 124(2), pp. 185-194. (doi: 10.1016/j.pharmthera.2009.06.013)

Kennedy, S. , Kane, K.A., Pyne, N.J. and Pyne, S. (2009) Targeting sphingosine-1-phosphate signalling for cardioprotection. Current Opinion in Pharmacology, 9(2), pp. 194-201. (doi: 10.1016/j.coph.2008.11.002)

2008

Dever, G.J., Benson, R., Wainwright, C.L., Kennedy, S. and Spickett, C.M. (2008) Phospholipid chlorohydrin induces leukocyte adhesion to ApoE−/− mouse arteries via upregulation of P-selectin. Free Radical Biology and Medicine, 44(3), pp. 452-463. (doi: 10.1016/j.freeradbiomed.2007.10.038)

Erridge, C., Kennedy, S. , Spickett, C.M. and Webb, D.J. (2008) Oxidised phospholipid inhibition of toll-like receptor (TLR) signalling is restricted to TLR2 and TLR4 - roles for CD14, LPS-binding protein and MD2 as targets for specificity of inhibition. Journal of Biological Chemistry, 283(36), pp. 24748-24759. (doi: 10.1074/jbc.M800352200)

Watt, J., Wadsworth, R., Kennedy, S. and Oldroyd, K. (2008) Pro-healing drug-eluting stents: a role for antioxidants? Clinical Science, 114(4), pp. 265-273. (doi: 10.1042/CS20070207) (PMID:18194135)

2007

Dever, G., Spickett, C.M., Kennedy, S. , Rush, C., Tennant, G., Monopoli, A. and Wainwright, C.L. (2007) The nitric oxide-donating pravastatin derivative, NCX 6550 [(1S-[1α(βS*,δS*), 2α ,6α,8 β-(R*),8aα]]-1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphtalene-heptanoic acid 4-(nitrooxy) butyl Ester)], Reduces Splenocyte Adhesion and Reactive Oxygen Species Generation in Normal and Atherosclerotic Mice. Journal of Pharmacology and Experimental Therapeutics, 320(1), pp. 419-426. (doi: 10.1124/jpet.106.109298)

Coats, P., Kennedy, S. , Pynea, S., Wainwright, C.L. and Wadsworth, R.M. (2007) Inhibition of non-Ras protein farnesylation reduces in-stent restenosis. Atherosclerosis, 197(2), pp. 515-523. (doi: 10.1016/j.atherosclerosis.2007.06.007)

Dever, G., Wainwright, C.L., Kennedy, S. and Spickett, C.M. (2007) Fatty acid and phospholipid chlorohydrins cause cell stress and endothelial adhesion. Acta Biochimica Polonica, 53(4), pp. 761-768.

Kennedy, S. , Burke, S.G., Preston, A.A. and McPhaden, A.R. (2007) Nitric oxide generation by NO donors is enhanced following balloon injury in the porcine coronary artery. Endothelium: Journal of Endothelial Cell Research, 14, pp. 105-113.

Maffia, P. , Zinselmeyer, B.H., Ialenti, A., Kennedy, S. , Baker, A.H., McInnes, I., Brewer, J.M. and Garside, P. (2007) Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery. Circulation, 115(11), E326-E328. (doi: 10.1161/CIRCULATIONAHA.106.658492) (PMID:17372180)

McCormick, C., Wadsworth, R.M., Jones, R.L. and Kennedy, S. (2007) Prostacyclin analogues: the next drug-eluting stent? Biochemical Society Transactions, 35(5), pp. 910-911. (doi: 10.1042/BST0350910)

Tennant, G.M., Wadsworth, R.M. and Kennedy, S. (2007) PAR-2 mediates increased inflammatory cell adhesion and neointima formation following vascular injury in the mouse. Atherosclerosis, 198(1), pp. 57-64.

2006

Kennedy, S. , Wadsworth, R.M. and Wainwright, C.L. (2006) Locally administered antiproliferative drugs inhibit hypercontractility to serotonin in balloon-injured pig coronary artery. Vascular Pharmacology, 44, pp. 363-371. (doi: 10.1016/j.vph.2006.01.012)

Lim, S.Y., Tennant, G.M., Kennedy, S. , Wainwright, C.L. and Kane, K.A. (2006) Activation of mouse protease-activated receptor-2 induces lymphocyte adhesion and generation of reactive oxygen species. British Journal of Pharmacology, 149, pp. 591-599. (doi: 10.1038/sj.bjp.0706905)

2004

Kennedy, S. , Preston, A.A., McPhaden, A.R., Miller, A.M., Wainwright, C.L. and Wadsworth, R.M. (2004) Correlation of changes in nitric oxide synthase, superoxide dismutase and nitrotyrosine with endothelial regeneration and neointimal hyperplasia in the balloon-injured rabbit subclavian artery. Coronary Artery Disease, 15(6), pp. 337-346. (doi: 10.1097/00019501-200409000-00007) (PMID:15346092)

2003

Kennedy, S. , Wadsworth, R.M. and Wainwright, C.L. (2003) Effect of antiproliferative agents on vascular function in nonnal and in vitro balloon-injured porcine coronary arteries. European Journal of Pharmacology, 481(1), pp. 101-107. (doi: 10.1016/j.ejphar.2003.09.010)

Kennedy, S. , Fournet-Bourguignon, M.-P., Breugnot, C., Castedo-Delrieu, M., Lesage, L., Reure, H., Briant, C., Leonce, S., Vilaine, J.-P. and Vanhoutte, P. M. (2003) Cells derived from regenerated endothelium of the porcine coronary artery contain more oxidized forms of apolipoprotein-B-100 without a modification in the uptake of oxidized LDL. Journal of Vascular Research, 40(4), (doi: 10.1159/000072817)

2001

Kennedy, S. , Miller, A. M., Wadsworth, R. M., McPhaden, A. R. and Wainwright, C. L. (2001) Validation of a technique to measure leukocyte adhesion to arterial segments: effects of drug treatments. Journal of Immunological Methods, 257(1-2), pp. 203-211. (doi: 10.1016/S0022-1759(01)00443-4) (PMID:11687253)

2000

Kennedy, S. , Wadsworth, R.M., McPhaden, A.R. and Wainwright, C.L. (2000) A rapid, quantitative method for measuring leukocyte adhesion to normal and balloon-injured arteries in vitro. Journal of Immunological Methods, 244(1-2), pp. 153-162. (doi: 10.1016/S0022-1759(00)00266-0) (PMID:11033028)

Kennedy, S. , McPhaden, A. R., Wadsworth, R. M. and Wainwright, C. L. (2000) Correlation of leukocyte adhesiveness, adhesion molecule expression and leukocyte-induced contraction following balloon angioplasty. British Journal of Pharmacology, 130(1), pp. 95-103. (doi: 10.1038/sj.bjp.0703282) (PMID:10781003) (PMCID:PMC1572038)

1998

Kennedy, S. , Work, L. , Ferris, P., Miller, A.M., McManus, B., Wadsworth, R.M. and Wainwright, C.L. (1998) Role of nitric oxide and free radicals in the contractile response to non-preactivated leukocytes. European Journal of Pharmacology, 345(3), pp. 269-277. (doi: 10.1016/S0014-2999(98)00007-7)

1997

Demiryürek, A.T., Kennedy, S. , Wainwright, C. L., Wadsworth, R.M. and Kane, K.A. (1997) Influence of nitric oxide on luminol-enhanced chemiluminescence measured from porcine-stimulated leukocytes. Journal of Cardiovascular Pharmacology, 30(3), pp. 332-337. (doi: 10.1097/00005344-199709000-00010) (PMID:9300317)

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Number of items: 73.

Articles

Ramses, R., Kennedy, S. , Good, R., Oldroyd, K. G. and Mcginty, S. (2024) Performance of drug-coated balloons in coronary and below-the-knee arteries: anatomical, physiological and pathological considerations. Vascular Pharmacology, 155, 107366. (doi: 10.1016/j.vph.2024.107366) (PMID:38479462)

Hoare, D., Kingsmore, D., Holsgrove, M., Russell, E., Kirimi, M. T., Czyzewski, J., Mirzai, N., Kennedy, S. , Neale, S. L. and Mercer, J. R. (2024) Realtime monitoring of thrombus formation in vivo using a self-reporting vascular access graft. Communications Medicine, 4, 15. (doi: 10.1038/s43856-024-00436-8) (PMID:38316912) (PMCID:PMC10844314)

Lyon, M., Fullerton, J. L. , Kennedy, S. and Work, L. M. (2023) Hypertension & dementia: pathophysiology & potential utility of antihypertensives in reducing disease burden. Pharmacology and Therapeutics, (doi: 10.1016/j.pharmthera.2023.108575) (PMID:38052309) (In Press)

McQueen, A., Escuer, J., Schmidt, A. F., Aggarwal, A. , Kennedy, S. , McCormick, C., Oldroyd, K. and Mcginty, S. (2022) An intricate interplay between stent drug dose and release rate dictates arterial restenosis. Journal of Controlled Release, 349, pp. 992-1008. (doi: 10.1016/j.jconrel.2022.07.037) (PMID:35921913)

McQueen, A., Escuer, J., Aggarwal, A. , Kennedy, S. , McCormick, C., Oldroyd, K. and Mcginty, S. (2021) Do we really understand how drug eluted from stents modulates arterial healing? International Journal of Pharmaceutics, 601, 120575. (doi: 10.1016/j.ijpharm.2021.120575) (PMID:33845150)

Abdulqader, A. and Kennedy, S. (2020) The influence of perivascular adipose tissue on vascular function in a rabbit model. Pharmacology and Pharmacy, 11, pp. 331-349. (doi: 10.4236/pp.2020.1112027)

Alganga, H. S. F., Almabrouk, T. A.M. , Katwan, O. J., Daly, C. J. , Pyne, S., Pyne, N. J. and Kennedy, S. (2019) Short periods of hypoxia upregulate sphingosine kinase 1 and increase vasodilation of arteries to Sphingosine 1-phosphate via S1P3. Journal of Pharmacology and Experimental Therapeutics, 371(1), pp. 63-74. (doi: 10.1124/jpet.119.257931) (PMID:31371480)

Katwan, O. J., Alghamdi, F., Almabrouk, T. A. , Mancini, S. J., Kennedy, S. , Oakhill, J. S., Scott, J. W. and Salt, I. P. (2019) AMP-activated protein kinase complexes containing the β2 regulatory subunit are upregulated during and contribute to adipogenesis. Biochemical Journal, 476(12), pp. 1725-1740. (doi: 10.1042/BCJ20180714) (PMID:31189568) (PMCID:PMC6595317)

McKittrick, C., McKee, S., Kennedy, S. , Oldroyd, K., Wheel, M., Pontrelli, G., Dixon, S., Mcginty, S. and McCormick, C. (2019) Combining mathematical modelling with in vitro experiments to predict in vivo drug-eluting stent performance. Journal of Controlled Release, 303, pp. 151-161. (doi: 10.1016/j.jconrel.2019.03.012) (PMID:30878363)

Ugusman, A. B., Riddell, A. and Kennedy, S. (2019) Effect of peroxynitrite (ONOO−) on the function of murine perivascular adipose tissue. Pharmacology and Pharmacy, 10(4), pp. 194-204. (doi: 10.4236/pp.2019.104017)

Greig, F. H. et al. (2019) Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse. European Journal of Pharmacology, 842, pp. 1-9. (doi: 10.1016/j.ejphar.2018.10.027) (PMID:30359564) (PMCID:PMC6318480)

Mancini, S. J., Boyd, D., Katwan, O. J., Strembitska, A., Almabrouk, T. A., Kennedy, S. , Palmer, T. M. and Salt, I. P. (2018) Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms. Scientific Reports, 8, 5276. (doi: 10.1038/s41598-018-23420-4) (PMID:29588466) (PMCID:PMC5869674)

Almabrouk, T. A.M. , White, A. D., Ugusman, A. B., Skiba, D. S., Katwan, O. J., Alganga, H., Guzik, T. J., Touyz, R. M. , Salt, I. P. and Kennedy, S. (2018) High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion. Frontiers in Physiology, 9, 51. (doi: 10.3389/fphys.2018.00051) (PMID:29479319) (PMCID:PMC5812172)

Almabrouk, T. A. M. , Ugusman, A. B., Katwan, O. J., Salt, I. P. and Kennedy, S. (2017) Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release. British Journal of Pharmacology, 174(20), pp. 3398-3410. (doi: 10.1111/bph.13633) (PMID:27668984)

Kennedy, S. and Salt, I. P. (2017) Molecular mechanisms regulating perivascular adipose tissue - potential pharmacological targets? British Journal of Pharmacology, 174(20), pp. 3385-3387. (doi: 10.1111/bph.13969) (PMID:28940457)

Wu, J., Lawrence, C., Wadsworth, R. M. and Kennedy, S. (2017) Perivascular mast cells promote neointimal elastin deposition and suppress chronic vein graft restenosis in hyperlipidaemic mice. Vessel Plus, 2017(1), pp. 137-144. (doi: 10.20517/2574-1209.2017.15)

Greig, F. H., Kennedy, S. , Gibson, G., Ramos, J. W. and Nixon, G. F. (2017) PEA-15 (phosphoprotein enriched in astrocytes 15) is a protective mediator in the vasculature and is regulated during neointimal hyperplasia. Journal of the American Heart Association, 6(9), e006936. (doi: 10.1161/JAHA.117.006936) (PMID:28893763) (PMCID:PMC5634313)

Ewart, M.-A., Ugusman, A., Vishwanath, A., Almabrouk, T. A.M., Alganga, H. S.F., Katwan, O. J., Hubanova, P., Currie, S. and Kennedy, S. (2017) Changes in IP3 receptor expression and function in aortic smooth muscle of atherosclerotic mice. Journal of Vascular Research, 54(2), pp. 68-78. (doi: 10.1159/000461581) (PMID:28365690) (PMCID:PMC5804831)

Houston, S. A., Ugusman, A., Gnanadesika, S. and Kennedy, S. (2017) An investigation of the antiplatelet effects of succinobucol (AGI-1067). Platelets, 28(3), pp. 295-300. (doi: 10.1080/09537104.2016.1218456) (PMID:27681689)

MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S. , Pyne, S. and Pyne, N. J. (2016) Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cellular Signalling, 28(8), pp. 946-955. (doi: 10.1016/j.cellsig.2016.03.014) (PMID:27063355) (PMCID:PMC4913619)

McCormick, C., Jones, R. L., Wadsworth, R. M., Mullen, A. B. and Kennedy, S. (2016) A polymer coated cicaprost-eluting stent increases neointima formation and impairs vessel function in the rabbit iliac artery. Pharmacology and Pharmacy, 7(6), pp. 226-235. (doi: 10.4236/pp.2016.76029)

McKittrick, C.M., Kennedy, S. , Oldroyd, K.G., Mcginty, S. and McCormick, C. (2016) Modelling the impact of atherosclerosis on drug release and distribution from coronary stents. Annals of Biomedical Engineering, 44(2), pp. 477-487. (doi: 10.1007/s10439-015-1456-7) (PMID:26384667) (PMCID:PMC4764635)

Watt, J., Kennedy, S. , Ahmed, N., Hayhurst, J., McClure, J. D. , Berry, C. , Wadsworth, R. M. and Oldroyd, K. G. (2016) The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD. Open Heart, 3(1), e000342. (doi: 10.1136/openhrt-2015-000342) (PMID:26848395) (PMCID:PMC4731840)

Greig, F. H., Ewart, M.-A., McNaughton, E., Cooney, J., Spickett, C. M. and Kennedy, S. (2015) The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice. Vascular Pharmacology, 74, pp. 93-102. (doi: 10.1016/j.vph.2015.07.010) (PMID:26196300) (PMCID:PMC4673085)

Wu, J., Grassia, G., Cambrook, H., Ialenti, A., MacRitchie, N., Carberry, J., Wadsworth, R. M., Lawrence, C., Kennedy, S. and Maffia, P. (2015) Perivascular mast cells regulate vein graft neointimal formation and remodeling. PeerJ, 3, e1192. (doi: 10.7717/peerj.1192) (PMID:26312183) (PMCID:PMC4548472)

Mckinney, C.A., Kennedy, S. , Baillie, G.S. , Milligan, G. and Nicklin, S.A. (2015) Angiotensin-(1-7) and angiotensin-(1-9) inhibit vascular smooth muscle cell growth and migration in vitro and vascular remodelling in vivo. Atherosclerosis, 241(1), e44. (doi: 10.1016/j.atherosclerosis.2015.04.158)

McDonald, R. A. et al. (2015) Reducing in-stent restenosis therapeutic manipulation of miRNA in vascular remodeling and inflammation. Journal of the American College of Cardiology, 65(21), pp. 2314-2327. (doi: 10.1016/j.jacc.2015.03.549) (PMID:26022821) (PMCID:PMC4444526)

Greig, F. H., Hutchison, L., Spickett, C. M. and Kennedy, S. (2015) Differential effects of chlorinated and oxidized phospholipids in vascular tissue: implications for neointima formation. Clinical Science, 128, pp. 579-592. (doi: 10.1042/CS20140578) (PMID:25524654)

Farmer, D. G.S., Ewart, M.-A., Mair, K. M. and Kennedy, S. (2014) Soluble receptor for advanced glycation end products (sRAGE) attenuates haemodynamic changes to chronic hypoxia in the mouse. Pulmonary Pharmacology and Therapeutics, 29(1), pp. 7-14. (doi: 10.1016/j.pupt.2014.01.002)

Ewart, M.-A., Kennedy, S. , MacMillan, D., Raja, A. L.N., Watt, I. M. and Currie, S. (2014) Altered vascular smooth muscle function in the ApoE knockout mouse during the progression of atherosclerosis. Atherosclerosis, 234(1), pp. 154-161. (doi: 10.1016/j.atherosclerosis.2014.02.014)

Almabrouk, T.A.M. , Ewart, M.-A., Salt, I.P. and Kennedy, S. (2014) Perivascular fat, AMP-activated protein kinase and vascular diseases. British Journal of Pharmacology, 171(3), pp. 595-617. (doi: 10.1111/bph.12479) (PMID:24490856) (PMCID:PMC3969075)

McDonald, R. A. et al. (2013) miRNA-21 is dysregulated in response to vein grafting in multiple models and genetic ablation in mice attenuates neointima formation. European Heart Journal, 34(22), pp. 1636-1643. (doi: 10.1093/eurheartj/eht105)

Kennedy, S. , Wu, J., Wadsworth, R.M., Lawrence, C.E. and Maffia, P. (2013) Mast cells and vascular diseases. Pharmacology and Therapeutics, 138(1), pp. 53-65. (doi: 10.1016/j.pharmthera.2013.01.001)

Watt, J., Kennedy, S. , McCormick, C., Agbani, E.O., McPhaden, A., Mullen, A., Czudaj, P., Behnisch, B., Wadsworth, R.M. and Oldroyd, K.G. (2013) Succinobucol-eluting stents increase neointimal thickening and peri-strut inflammation in a porcine coronary model. Catheterization and Cardiovascular Interventions, 81(4), pp. 698-708. (doi: 10.1002/ccd.24473)

Ewart, M.-A. and Kennedy, S. (2012) Diabetic cardiovascular disease AMP-activated protein kinase (AMPK) as a therapeutic target. Cardiovascular and Hematological Agents in Medicinal Chemistry, 10(3), pp. 190-211. (doi: 10.2174/187152512802651015)

Watt, J., Ewart, M.-A., Greig, F. H., Oldroyd, K. G., Wadsworth, R. M. and Kennedy, S. (2012) The effect of reactive oxygen species on whole blood aggregation and the endothelial cell-platelet interaction in patients with coronary heart disease. Thrombosis Research, 130(2), pp. 210-215. (doi: 10.1016/j.thromres.2012.03.024)

Greig, F. H., Kennedy, S. and Spickett, C. M. (2012) Physiological effects of oxidized phospholipids and their cellular signaling mechanisms in inflammation. Free Radical Biology and Medicine, 52(2), pp. 266-280. (doi: 10.1016/j.freeradbiomed.2011.10.481)

Watt, J., Ewart, M.-A., Greig, F.H., Oldroyd, K.G., Wadsworth, R.M. and Kennedy, S. (2012) The effect of reactive oxygen species on whole blood aggregation and the enothelial cell-platelet interaction in patients with coronary heart disease. Thrombosis Research, 130(2), pp. 210-215. (doi: 10.1016/j.thromres.2012.03.024)

Ialenti, A. et al. (2011) Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(11), pp. 2448-2454. (doi: 10.1161/ATVBAHA.111.230078) (PMID:21852559)

Ewart, M.-A. and Kennedy, S. (2011) AMPK and vasculoprotection. Pharmacology and Therapeutics, 131(2), pp. 242-253. (doi: 10.1016/j.pharmthera.2010.11.002)

Wu, J., Wadsworth, R.M. and Kennedy, S. (2011) Inhibition of inducible Nitric Oxide synthase promotes vein graft neoadventitial inflammation and remodelling. Journal of Vascular Research, 48(2), pp. 141-149. (doi: 10.1159/000316968)

Grassia, G. et al. (2010) The IkB kinase inhibitor nuclear factor-kB essential modulator–binding domain peptide for inhibition of balloon injury-induced neointimal formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(12), pp. 2458-2466. (doi: 10.1161/ATVBAHA.110.215467) (PMID:20930169)

Shedden, L., Kennedy, S. , Wadsworth, R. and Connolly, P. (2010) Towards a self-reporting coronary artery stent—Measuring neointimal growth associated with in-stent restenosis using electrical impedance techniques. Biosensors and Bioelectronics, 26(2), pp. 661-666. (doi: 10.1016/j.bios.2010.06.073) (PMID:20667708)

McCormick, C., Jones, R.L., Kennedy, S. and Wadsworth, R.M. (2010) Activation of prostanoid EP receptors by prostacyclin analogues in rabbit iliac artery: Implications for anti-restenotic potential. European Journal of Pharmacology, 641(2-3), pp. 160-167. (doi: 10.1016/j.ejphar.2010.04.035)

Mair, K.M., Robinson, E., Kane, K.A., Pyne, S., Brett, R.R., Pyne, N.J. and Kennedy, S. (2010) Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. British Journal of Pharmacology, 161(1), pp. 176-192. (doi: 10.1111/j.1476-5381.2010.00878.x)

Lim, S.Y., Wainwright, C.L., Kennedy, S. and Kane, K.A. (2009) Activation of protease activated receptor-2 induces delayed cardioprotection in anesthetized mice. Cardiovascular Drugs and Therapy, 23(6), pp. 519-520. (doi: 10.1007/s10557-007-6073-8)

Farmer, D.G.S. and Kennedy, S. (2009) RAGE, vascular tone and vascular disease. Pharmacology and Therapeutics, 124(2), pp. 185-194. (doi: 10.1016/j.pharmthera.2009.06.013)

Kennedy, S. , Kane, K.A., Pyne, N.J. and Pyne, S. (2009) Targeting sphingosine-1-phosphate signalling for cardioprotection. Current Opinion in Pharmacology, 9(2), pp. 194-201. (doi: 10.1016/j.coph.2008.11.002)

Dever, G.J., Benson, R., Wainwright, C.L., Kennedy, S. and Spickett, C.M. (2008) Phospholipid chlorohydrin induces leukocyte adhesion to ApoE−/− mouse arteries via upregulation of P-selectin. Free Radical Biology and Medicine, 44(3), pp. 452-463. (doi: 10.1016/j.freeradbiomed.2007.10.038)

Erridge, C., Kennedy, S. , Spickett, C.M. and Webb, D.J. (2008) Oxidised phospholipid inhibition of toll-like receptor (TLR) signalling is restricted to TLR2 and TLR4 - roles for CD14, LPS-binding protein and MD2 as targets for specificity of inhibition. Journal of Biological Chemistry, 283(36), pp. 24748-24759. (doi: 10.1074/jbc.M800352200)

Watt, J., Wadsworth, R., Kennedy, S. and Oldroyd, K. (2008) Pro-healing drug-eluting stents: a role for antioxidants? Clinical Science, 114(4), pp. 265-273. (doi: 10.1042/CS20070207) (PMID:18194135)

Dever, G., Spickett, C.M., Kennedy, S. , Rush, C., Tennant, G., Monopoli, A. and Wainwright, C.L. (2007) The nitric oxide-donating pravastatin derivative, NCX 6550 [(1S-[1α(βS*,δS*), 2α ,6α,8 β-(R*),8aα]]-1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphtalene-heptanoic acid 4-(nitrooxy) butyl Ester)], Reduces Splenocyte Adhesion and Reactive Oxygen Species Generation in Normal and Atherosclerotic Mice. Journal of Pharmacology and Experimental Therapeutics, 320(1), pp. 419-426. (doi: 10.1124/jpet.106.109298)

Coats, P., Kennedy, S. , Pynea, S., Wainwright, C.L. and Wadsworth, R.M. (2007) Inhibition of non-Ras protein farnesylation reduces in-stent restenosis. Atherosclerosis, 197(2), pp. 515-523. (doi: 10.1016/j.atherosclerosis.2007.06.007)

Dever, G., Wainwright, C.L., Kennedy, S. and Spickett, C.M. (2007) Fatty acid and phospholipid chlorohydrins cause cell stress and endothelial adhesion. Acta Biochimica Polonica, 53(4), pp. 761-768.

Kennedy, S. , Burke, S.G., Preston, A.A. and McPhaden, A.R. (2007) Nitric oxide generation by NO donors is enhanced following balloon injury in the porcine coronary artery. Endothelium: Journal of Endothelial Cell Research, 14, pp. 105-113.

Maffia, P. , Zinselmeyer, B.H., Ialenti, A., Kennedy, S. , Baker, A.H., McInnes, I., Brewer, J.M. and Garside, P. (2007) Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery. Circulation, 115(11), E326-E328. (doi: 10.1161/CIRCULATIONAHA.106.658492) (PMID:17372180)

McCormick, C., Wadsworth, R.M., Jones, R.L. and Kennedy, S. (2007) Prostacyclin analogues: the next drug-eluting stent? Biochemical Society Transactions, 35(5), pp. 910-911. (doi: 10.1042/BST0350910)

Tennant, G.M., Wadsworth, R.M. and Kennedy, S. (2007) PAR-2 mediates increased inflammatory cell adhesion and neointima formation following vascular injury in the mouse. Atherosclerosis, 198(1), pp. 57-64.

Kennedy, S. , Wadsworth, R.M. and Wainwright, C.L. (2006) Locally administered antiproliferative drugs inhibit hypercontractility to serotonin in balloon-injured pig coronary artery. Vascular Pharmacology, 44, pp. 363-371. (doi: 10.1016/j.vph.2006.01.012)

Lim, S.Y., Tennant, G.M., Kennedy, S. , Wainwright, C.L. and Kane, K.A. (2006) Activation of mouse protease-activated receptor-2 induces lymphocyte adhesion and generation of reactive oxygen species. British Journal of Pharmacology, 149, pp. 591-599. (doi: 10.1038/sj.bjp.0706905)

Kennedy, S. , Preston, A.A., McPhaden, A.R., Miller, A.M., Wainwright, C.L. and Wadsworth, R.M. (2004) Correlation of changes in nitric oxide synthase, superoxide dismutase and nitrotyrosine with endothelial regeneration and neointimal hyperplasia in the balloon-injured rabbit subclavian artery. Coronary Artery Disease, 15(6), pp. 337-346. (doi: 10.1097/00019501-200409000-00007) (PMID:15346092)

Kennedy, S. , Wadsworth, R.M. and Wainwright, C.L. (2003) Effect of antiproliferative agents on vascular function in nonnal and in vitro balloon-injured porcine coronary arteries. European Journal of Pharmacology, 481(1), pp. 101-107. (doi: 10.1016/j.ejphar.2003.09.010)

Kennedy, S. , Fournet-Bourguignon, M.-P., Breugnot, C., Castedo-Delrieu, M., Lesage, L., Reure, H., Briant, C., Leonce, S., Vilaine, J.-P. and Vanhoutte, P. M. (2003) Cells derived from regenerated endothelium of the porcine coronary artery contain more oxidized forms of apolipoprotein-B-100 without a modification in the uptake of oxidized LDL. Journal of Vascular Research, 40(4), (doi: 10.1159/000072817)

Kennedy, S. , Miller, A. M., Wadsworth, R. M., McPhaden, A. R. and Wainwright, C. L. (2001) Validation of a technique to measure leukocyte adhesion to arterial segments: effects of drug treatments. Journal of Immunological Methods, 257(1-2), pp. 203-211. (doi: 10.1016/S0022-1759(01)00443-4) (PMID:11687253)

Kennedy, S. , Wadsworth, R.M., McPhaden, A.R. and Wainwright, C.L. (2000) A rapid, quantitative method for measuring leukocyte adhesion to normal and balloon-injured arteries in vitro. Journal of Immunological Methods, 244(1-2), pp. 153-162. (doi: 10.1016/S0022-1759(00)00266-0) (PMID:11033028)

Kennedy, S. , McPhaden, A. R., Wadsworth, R. M. and Wainwright, C. L. (2000) Correlation of leukocyte adhesiveness, adhesion molecule expression and leukocyte-induced contraction following balloon angioplasty. British Journal of Pharmacology, 130(1), pp. 95-103. (doi: 10.1038/sj.bjp.0703282) (PMID:10781003) (PMCID:PMC1572038)

Kennedy, S. , Work, L. , Ferris, P., Miller, A.M., McManus, B., Wadsworth, R.M. and Wainwright, C.L. (1998) Role of nitric oxide and free radicals in the contractile response to non-preactivated leukocytes. European Journal of Pharmacology, 345(3), pp. 269-277. (doi: 10.1016/S0014-2999(98)00007-7)

Demiryürek, A.T., Kennedy, S. , Wainwright, C. L., Wadsworth, R.M. and Kane, K.A. (1997) Influence of nitric oxide on luminol-enhanced chemiluminescence measured from porcine-stimulated leukocytes. Journal of Cardiovascular Pharmacology, 30(3), pp. 332-337. (doi: 10.1097/00005344-199709000-00010) (PMID:9300317)

Book Sections

Kennedy, S. and Touyz, R. M. (2019) Anatomy and pharmacology of vessels. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 3-11. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_1)

Conference or Workshop Item

McQueen, A., Kennedy, S. , McCormick, C., Aggarwal, A. and McGinty, S. (2020) Mathematical Modelling of the Effect of Drug on Smooth Muscle Cell Proliferation. Scottish Cardiovascular Forum 2020, 23rd Annual Meeting, Glasgow, UK, 1 Feb 2020.

Conference Proceedings

McGinty, S. , McCormick, C., McKittrick, C., Kennedy, S. , Oldroyd, K., Wheel, M., Scullion, B., Pontrelli, G. and McKee, S. (2017) Combining Mathematical Modelling with In-Vitro Experiments to Predict In-Vivo Drug-Eluting Stent Kinetics. In: 5 th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017), Pittsburgh, PA, USA, 10-12 April 2017, pp. 1011-1014. ISBN 9780956291448

McGinty, S. , Wheel, M., McKee, S., McCormick, C., McKittrick, C., Kennedy, S. and Oldroyd, K. (2015) Can Anisotropy Enhance the Spatial Uniformity of Drug Distribution in Biological Tissue? In: 4th International Conference on Computational & Mathematical Biomedical Engineering, Paris, France, 29 June - 1 July 2015, pp. 194-197. ISBN 9780956291431

Guglielmotti, A., Grassia, G., Gordon, P., Maddaluno, M., Di Lauro, M.V., Biondi, G., Colombo, A., Ialenti, A., Maffia, P. and Kennedy, S. (2010) Bindarit, an inhibitor of monocyte chemoattractant proteins (MCPs) production, reduces in-stent restenosis in porcine coronary arteries. In: American Heart Association Scientific Session 2010, Chicago, IL, 13-17 Nov 2010, A11429.

This list was generated on Wed Apr 17 08:59:59 2024 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Emblation - Pre-Clinical Research Work
    Scottish Funding Council
    2016 - 2016
     
  • Angiotensin-(1-7) and angiotensin-(1-9): assessment as therapeutic targets in acute vascular injury and remodelling.
    Medical Research Council
    2014 - 2017
     
  • Investigation of Novel protein pathways which regulate vascular smooth muscle cell phenotype in neointimal hyperplasia
    Medical Research Council
    2013 - 2016
     
  • Optimal Design of Drug Eluting Stents
    Engineering and Physical Sciences Research Council
    2012 - 2015
     
  • Evaluation of Mirna and their therapeutic potential in a Mouse Model of In-Stent Restenosis
    British Heart Foundation
    2011 - 2014
     
  • Involvement of AMPK in calcium regulation in atherosclerotic blood vessels.
    British Heart Foundation
    2011 - 2014
     
  • Importance of mast cells in vein graft survival
    British Heart Foundation
    2010 - 2012
     
  • Involvement of chlorinated lipids in neointima formation.
    British Heart Foundation
    2008 - 2011
     
  • Optimisation and analysis of integrating and non-integrating lentiviruses for vascular gene transfer in vivo - application to in-stent restenosis with delivery of Nogo-B
    British Heart Foundation
    2008 - 2011
     
  • Modulation of calcium handling mechanisms in healthy and atherosclerotic vascular smooth muscle
    British Heart Foundation
    2007 - 2010
     
  • Cardio protection and the modulation of vascular tone by anandamide is mediated by sphingosine-1-phosphate
    British Heart Foundation
    2007 - 2009
     

Supervision

Current PhD students:

2020 – Ibrahim Al-Jaezi (in collaboration with Dr Kenneth Watterson)

2019 - Saad Wali (in collaboration with Dr Yvonne Dempsie)

2019 - Abdmajid Saad Hwej (in collaboration with Dr Ian Salt)

2018 - Ali Abdulmajid Ali Al-Ferjiani (in collaboration with Dr Ian Salt) 

2018 - Alistair McQueen (LKAS studentship in collaboration with Dr Sean McGinty)

2018 - Antoniya Pashova (in collaboration with Professor Stuart Nicklin)

Previously completed MD or PhD students (since 2006) as either primary or secondary supervisor:

2019 - Omar J Katwan, sponsored by Iraqi Government

2018 - Husam Alganga, sponsored by Libyan Government

2017 - Tarek A. M. Almabrouk, sponsored by Libyan Government

2015 - Crawford Halliday, sponsored by British Heart Foundation

2013 - Keith Robertson, sponsored by British Heart Foundation

2012 - Fiona H. Greig, sponsored British Heart Foundation

2011 - David G.S. Farmer, sponsored by Integrated Mammalian Biology Initiative

2008 - Christopher McCormick, sponsored by Bioengineeing Doctoral Training Programme (EngD)

2008 - Laurie Sheddan, sponsored by Bioengineering Doctoral Training Programme (EngD)

2008 - Edwin Carter, sponsored by Bioaccelerate (MPhil)

2007 - Emma Robinson, sponsored by British Heart Foundation

2007 - Gail Tennant, sponsored by British Heart Foundation

2007 - Gary Dever, employed as Graduate Teaching Assistant

Teaching

Dr Kennedy teaches primarily at levels 3 and 4 within the School of Life sciences but also teaches at level 1 of the MBChB and BDS degrees.

His teaching ranges from fundamental physiology of the cardiovascular system at lower levels through to research-led teaching on final year option courses at Level 4 as well as co-ordinating and contributing to a practical option course which teaches in vivo research techniques.

Simon supervises research projects in his laboratory for final-year students on Physiology, Pharmacology, and Human Biology degrees in addition to supervising post-graduate projects on courses, such as the MSc in Clinical Pharmacology and the MSc in Biotechnology and Management.

The projects offered to students are aligned to the research being carried out by PhD students and this often leads to students being co-authors on publications.

Professional activities & recognition

Editorial boards

  • - 2020 British Journal of Pharmacology
  • Pharmacology & Therapeutics
  • Vessel Plus

Professional & learned societies

  • 2004: Treasurer, Scottish Cardiovascular Forum
  • 1994: Member, Royal Pharmaceutical Society
  • 2014: Member, British Pharmacological Society

Selected international presentations

  • 2011: BPS Symposium (London, UK)
  • 2007: Invited Communication, 9th ISRA meeting (Hamilton Island, Australia)
  • 2008: Departmental Seminar, UHI Millennium Institute (Inverness, Scotland)
  • 2007: Symposium Chair, Life Sciences 2007 meeting (Glasgow, Scotland)
  • 2005: House of Commons poster reception. UK Science week- poster chosen for presentation (London, UK)
  • 2013: Departmental Seminar (Manchester, UK)
  • 2004: Departmental Seminar, International Medical University (Kuala Lumpur)
  • 2004: Co-chair and invited speaker at symposium. International Society for Heart Research (Brisbane, Australia)
  • 2018: Invited Plenary Speaker (Kuala Lumpur, Malaysia)
  • 2015: Chair and Symposium Organiser (London, UK)
  • 2019: Departmental Seminar, UKM, Kuala Lumpur (Kuala Lumpur, Malaysia)
  • 2016: Invited Speaker (Xian, China)

A head and shoulders profile image of Dr Simon Kennedy