Professor Lubna Nasir

Professor of Comparative Oncology (Veterinary Science & Education )

telephone: 01413305731
email: Lubna.Nasir@glasgow.ac.uk

Jarrett Building, School of Veterinary Medicine, Bearsden Road, Glasgow, G61 1QH

Research interests

My principal research interests are focussed on the molecular mechanisms that promote immortalisation and transformation of animal cells as well as the identification of novel targets for therapeutic cancer intervention. Of particular interest, is the role of Bovine Papillomaviruses (BPV) types 1 and 2 in the pathogenesis of equine sarcoid skin tumours. The disease is associated with BPV-1/2 infection and sarcoids represent the first known natural cross species papillomaviral infection.

Current projects are aimed at furthering the understanding of the viral pathogenesis of sarcoids by studying the mechanisms by which viral infection can induce cell transformation and cell invasion and interactions of virus with host cell defences. Further, we are attempting to understanding the infectious nature of the disease and the mechanisms of disease transmission. We are also actively engaged in evolutionary studies of the worldwide distribution of BPV variants in equids and bovids.

The lab is also evaluating RNA interference as a tool to silence viral gene expression as a potential therapeutic modality. In summary my group combines the disciplines of comparative biology, virology, molecular and cell biology to study virus host interactions and disease transmission of BPV in a non-natural host.

Research groups

Educational Research & Scholarship

Publications

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Number of items: 64.

2023

Moore, E., Dowell, F., MacEachern, K. and Nasir, L. (2023) First Steps to Decolonising the Veterinary Curriculum. VSC Veterinary Education Symposium (VetEd 2023), Edinburgh, UK, 6-7 July 2023.

2017

Terron-Canedo, N., Weir, W. , Nicolson, L., Britton, C. and Nasir, L. (2017) Differential expression of microRNAs in bovine papillomavirus type 1 transformed equine cells. Veterinary and Comparative Oncology, 15(3), pp. 764-774. (doi: 10.1111/vco.12216) (PMID:27039895)

2016

Abel-Reichwald, H., Hainisch, E. K., Zahalka, S., Corteggio, A., Borzacchiello, G., Massa, B., Merlone, L., Nasir, L., Burden, F. and Brandt, S. (2016) Epidemiologic analysis of a sarcoid outbreak involving 12 of 111 donkeys in Northern Italy. Veterinary Microbiology, 196, pp. 85-92. (doi: 10.1016/j.vetmic.2016.10.021) (PMID:27939161)

Staiger, E. A., Tseng, C. T., Miller, D., Cassano, J. M., Nasir, L., Garrick, D., Brooks, S. A. and Antczak, D. F. (2016) Host genetic influence on papillomavirus-induced tumors in the horse. International Journal of Cancer, 139(4), pp. 784-792. (doi: 10.1002/ijc.30120) (PMID:27037728)

2014

Trewby, H. et al. (2014) Analysis of the long control region of bovine papillomavirus type 1 associated with sarcoids in equine hosts indicates multiple cross-species transmission events and phylogeographical structure. Journal of General Virology, 95(Pt 12), pp. 2748-2756. (doi: 10.1099/vir.0.066589-0)

Stocco, R.C., Roperto, F.P., Nasir, L. and Sircili, M.P. (2014) Oncogenic processes. BioMed Research International, 2014(879013), (doi: 10.1155/2014/879013)

2013

Nasir, L. and Brandt, S. (2013) Papillomavirus associated diseases of the horse. Veterinary Microbiology, 167(1-2), pp. 159-167. (doi: 10.1016/j.vetmic.2013.08.003)

Altamura, G., Corteggio, A., Nasir, L., Yuan, Z., Roperto, F. and Borzacchiello, G. (2013) Analysis of activated platelet-derived growth factor β receptor and Ras-MAP kinase pathway in equine sarcoid fibroblasts. BioMed Research International, 2013(283985), (doi: 10.1155/2013/283985)

Foster, A.P., Barlow, A.M., Nasir, L., Wilson, C.D., Everest, D.J., Erdelyi, K., Finnegan, C.J. and Schock, A. (2013) Fibromatous lesions of antler velvet and haired skin in reindeer (Rangifer tarandus). Veterinary Record, 172(17), p. 452. (doi: 10.1136/vr.101499)

2012

Finlay, M., Yuan, Z., Morgan, I.M., Campo, M. and Nasir, L. (2012) Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53. Veterinary Research, 43, p. 81. (doi: 10.1186/1297-9716-43-81)

2011

Yuan, Z., Gault, E. A., Campo, M. S. and Nasir, L. (2011) p38 MAPK is crucial for BPV-1 transformation of equine fibroblasts. Journal of General Virology, 92(8), pp. 1778-1786. (doi: 10.1099/vir.0.031526-0) (PMID:21471309)

Yuan, Z., Gault, E.A., Campo, M.S. and Nasir, L. (2011) Different contribution of bovine papillomavirus type 1 oncoproteins to the transformation of equine fibroblasts. Journal of General Virology, 92(4), pp. 773-783. (doi: 10.1099/vir.0.028191-0)

Foote, C. G., Gault, E. A., Nasir, L. and Monaghan, P. (2011) Telomere dynamics in relation to early growth conditions in the wild in the lesser black-backed gull. Journal of Zoology, 283(3), pp. 203-209. (doi: 10.1111/j.1469-7998.2010.00774.x)

Brandt, S., Tober, R., Corteggio, A., Burger, S., Sabitzer, S., Walter, I., Kainzbauer, C., Steinborn, R., Nasir, L. and Borzacchiello, G. (2011) BPV-1 infection is not confined to the dermis but also involves the epidermis of equine sarcoids. Veterinary Microbiology, 150(1-2), pp. 35-40. (doi: 10.1016/j.vetmic.2010.12.021)

Venuti, A., Paolini, F., Nasir, L., Corteggio, A., Roperto, S., Campo, M.S. and Borzacchiello, G. (2011) Papillomavirus E5: the smallest oncoprotein with many functions. Molecular Cancer, 10(140), (doi: 10.1186/1476-4598-10-140)

Yuan, Z., Gault, E.A., Campo, M.S. and Nasir, L. (2011) Upregulation of equine matrix metalloproteinase 1 by bovine papillomavirus type 1 is through the transcription factor activator protein-1. Journal of General Virology, 92(11), pp. 2608-2619. (doi: 10.1099/vir.0.033431-0)

2010

Arendt, M. L., Nasir, L. and Morgan, I. M. (2010) The human and canine TERT promoters function equivalently in human and canine cells. Veterinary and Comparative Oncology, 8(4), pp. 310-316. (doi: 10.1111/j.1476-5829.2010.00227.x)

Yuan, Z.Q., Bennett, l., Campo, S. and Nasir, L. (2010) Bovine papillomavirus type 1 E2 and E7 proteins down-regulate Toll Like Receptor 4 (TLR4) expression in equine fibroblasts. Virus Research, 149(1), pp. 124-127. (doi: 10.1016/j.virusres.2010.01.008)

Yuan, Z.Q., Gobeil, P., Campo, S. and Nasir, L. (2010) Equine sarcoid fibroblasts over-express matrix metalloproteinases and are invasive. Virology, 396(1), pp. 143-151. (doi: 10.1016/j.virol.2009.10.010)

2009

Marchetti, B., Gault, E.A., Cortese, M.S., Yuan, Z.Q., Ellis, S.A., Nasir, L. and Campo, M.S. (2009) Bovine papillomavirus type 1 oncoprotein E5 inhibits equine MHC class I and interacts with equine MHC I heavy chain. Journal of General Virology, 90(12), pp. 2865-2870. (doi: 10.1099/vir.0.014746-0) (PMID:19675187)

Criscuolo, F., Bize, P., Nasir, L., Metcalfe, N.B., Foote, C.G., Griffiths, K., Gault, E.A. and Monaghan, P. (2009) Real-time quantitative PCR assay for measurement of avain telomeres. Journal of Avian Biology, 40(3), pp. 342-347. (doi: 10.1111/j.1600-048X.2008.04623.x)

Bize, P., Criscuolo, F., Metcalfe, N.B., Nasir, L. and Monaghan, P. (2009) Telomere dynamics rather than age predict life expectancy in the wild. Proceedings of the Royal Society of London Series B: Biological Sciences, 276(1662), pp. 1679-1683. (doi: 10.1098/rspb.2008.1817) (PMID:19324831) (PMCID:PMC2660992)

Arendt, M., Nasir, L. and Morgan, I.M. (2009) Oncolytic gene therapy for canine cancers: teaching old dog viruses new tricks. Veterinary and Comparative Oncology, 7(3), pp. 153-161. (doi: 10.1111/j.1476-5829.2009.00187.x)

Arendt, M.L., Nasir, L. and Morgan, I.M. (2009) A novel two-step transcriptional activation system for gene therapy directed toward epithelial cells. Molecular Cancer Therapeutics, 8(12), pp. 3244-3254. (doi: 10.1158/1535-7163.MCT-09-0543)

Borzacchiello, G., Roperto, F., Nasir, L. and Campo, M.S. (2009) Human papillomavirus research: Do we still need animal models? International Journal of Cancer, 125(3), pp. 739-740. (doi: 10.1002/ijc.24430)

Finlay, M., Yuan, Z.Q., Burden, F., Trawford, A., Morgan, I.M., Campo, M.S. and Nasir, L. (2009) The detection of Bovine Papillomavirus type 1 DNA in flies. Virus Research, 144(1-2), pp. 315-317. (doi: 10.1016/j.virusres.2009.04.015)

Gobeil, P.A.M., Yuan, Z.Q., Gault, E.A., Morgan, I.M., Campo, M.S. and Nasir, L. (2009) Small interfering RNA targeting bovine papillomavirus type 1 E2 induces apoptosis in equine sarcoid transformed fibroblasts. Virus Research, 145(1), pp. 162-165. (doi: 10.1016/j.virusres.2009.06.019)

2008

Yuan, Z.Q., Nicolson, L., Marchetti, B., Gault, E.A., Campo, M.S. and Nasir, L. (2008) Transcriptional changes induced by bovine papillomavirus type 1 in equine fibroblasts. Journal of Virology, 82(13), pp. 6481-6491. (doi: 10.1128/JVI.00429-08)

Morris, J. , Nixon, C., Bruck, A., Nasir, L., Morgan, I.M. and Philbey, A. (2008) Immunohistochemical expression of TopBP1 in feline mammary neoplasia in relation to histological grade, Ki67, ERα and p53. Veterinary Journal, 175(2), pp. 218-226. (doi: 10.1016/j.tvjl.2007.01.006)

Arendt, M.L., Morris, J. , Nasir, L. and Morgan, I.M. (2008) Abstracts presented at the ESVONC spring meeting, Cambridge, UK, 23-25 March 2007. Veterinary and Comparative Oncology, 6(1), pp. 65-83.

Helm, J.R., Nicholson, I., Nasir, L. and Knottenbelt, C.M. (2008) A study into the effects of meloxicam and piroxicam on telomerase activity in canine transitional cell carcinoma. In: 1st WorldVetCancer Joint ESVONC & VCS Meeting, Fredericksberg, Denmark, 28 Feb - 1 Mar 2008, p. 49.

Helm, J.R., Nicholson, I., Nasir, L., Morris, J. and Knottenbelt, C. M. (2008) A preliminary study into the effects of meloxicam and piroxicam on telomerase activity in canine malignant melanoma. In: 51st British Small Animal Veterinary Association (BSAVA) Congress 2008, Birmingham UK, 3-6 April 2008, p. 496.

Nasir, L. (2008) Telomeres and telomerase: Biological and clinical importance in dogs. Veterinary Journal, 175(2), pp. 155-163. (doi: 10.1016/j.tvjl.2007.01.024)

Nasir, L. and Campo, M.S. (2008) Bovine papillomaviruses: their role in the aetiology of cutaneous tumours of bovids and equids. Veterinary Dermatology, 19(5), pp. 243-254. (doi: 10.1111/j.1365-3164.2008.00683.x)

Yuan, Z.Q., Gault, E., Gobeil, P., Nixon, C., Campo, M.S. and Nasir, L. (2008) Establishment and characterization of equine fibroblast cell lines transformed in vivo and in vitro by BPV-1: model systems for equine sarcoids. Virology, 373(2), pp. 352-361. (doi: 10.1016/j.virol.2007.11.037)

2007

Campbell, S.E., Nasir, L., Gault, E.A., Argyle, D.J. and Bennett, D. (2007) Preliminary studies of particle-mediated gene delivery to the joints of dogs. Veterinary Record, 160(14), pp. 476-481. (doi: 10.1136/vr.160.14.476)

Gobeil, P., Gault, E.A., Campo, M.S., Gow, J., Morgan, I.M. and Nasir, L. (2007) Equine sarcoids are not induced by an infectious cell line. Equine Veterinary Journal, 39, pp. 189-191. (doi: 10.2746/042516407X179879)

Long, S., Argyle, D., Gault, E. and Nasir, L. (2007) Inhibition of telomerase in canine cancer cells following telomestatin treatment. Veterinary and Comparative Oncology, 5, pp. 99-107.

Nasir, L. (2007) Telomeres and telomerase: Biological and clinical importance in dogs. Veterinary Journal,

Nasir, L., Gault, E., Morgan, I., Chambers, G., Ellsmore, V. and Campo, M. (2007) Identification and functional analysis of sequence variants in the long control region and the E2 open reading frame of bovine papillomavirus type 1 isolated from equine sarcoids. Virology, 364, pp. 355-361. (doi: 10.1016/j.virol.2007.02.019)

Nicholson, I., Gault, E., Foote, C.G., Nasir, L. and Bennett, D. (2007) Human telomerase reverse transcriptase (hTERT) extends the lifespan of canine chondrocytes in vitro without inducing neoplastic transformation. Veterinary Journal, 174(3), pp. 570-576. (doi: 10.1016/j.tvjl.2007.07.009)

Nicholson, L.P., Gault, E.A., Foote, C.G., Nasir, L. and Bennett, D. (2007) Human telomerase reverse transcriptase (hTERT) extends the lifespan of canine chondrocytes in vitro without inducing neoplastic transformation. Veterinary Journal, 174(3), pp. 570-576. (doi: 10.1016/j.tvjl.2007.07.009)

Yuan, Z., Gallagher, A., Gault, E., Campo, S. and Nasir, L. (2007) Bovine papillomavirus infection in equine sarcoids and in bovine bladder cancers. Veterinary Journal, 174(3), pp. 599-604. (doi: 10.1016/j.tvjl.2006.10.012)

Yuan, Z.Q., Philbey, A.W., Gault, E.A., Campo, M.S. and Nasir, L.N. (2007) Detection of bovine papillomavirus type 1 genomes and viral gene expression in equine inflammatory skin conditions. Virus Research, 124, pp. 245-249. (doi: 10.1016/j.virusres.2006.10.012)

2006

Long, S. et al. (2006) Telomerase reverse transcriptase (TERT) expression and proliferation in canine brain tumours. Neuropathology and Applied Neurobiology, 32, pp. 662-673. (doi: 10.1111/j.1365-2990.2006.00776.x)

Renwick, M., Argyle, D., Long, S., Nixon, C., Gault, E. and Nasir, L. (2006) Telornerase activity and telomerase reverse transcriptase catalytic subunit expression in canine lymphoma: correlation with Ki67 immunoreactivity. Veterinary and Comparative Oncology, 4, pp. 141-150.

2005

Campbell, S., Bennett, D., Nasir, L., Gault, E. and Argyle, D. (2005) Disease- and cell-type-specific transcriptional targeting of vectors for osteoarthritis gene therapy: further development of a clinical canine model. Rheumatology, 44(6), pp. 735-743. (doi: 10.1093/rheumatology/keh590)

Dale, V.H.M. , Nasir, L. and Sullivan, M. (2005) Evaluation of student attitudes to cooperative learning in undergraduate veterinary medicine. Journal of Veterinary Medical Education, 32(4), pp. 511-516.

Dale, V.H.M. , Nasir, L. and Sullivan, M. (2005) Exploring student attitudes to directed self-learning online through evaluation of an Internet-based biomolecular sciences resource. Journal of Veterinary Medical Education, 32(1), pp. 129-137. (doi: 10.3138/jvme.32.1.129)

Long, S., Argyle, D., Gault, E., Campbell, S. and Nasir, L. (2005) The canine telomerase catalytic subunit (dogTERT): Characterisation of the gene promoter and identification of proximal core sequences necessary for specific transcriptional activity in canine telomerase positive cell lines. Gene, 358, pp. 111-120. (doi: 10.1016/j.gene.2005.05.030)

Nixon, C., Chambers, G., Ellsmore, V., Campo, M., Burr, P., Argyle, D., Reid, S. and Nasir, L. (2005) Expression of cell cycle associated proteins cyclin A, CDK-2, p27(kip1) and p53 in equine sarcoids. Cancer Letters, 221, pp. 237-245. (doi: 10.1016/j.canlet.2004.08.039)

2004

Hall, M., Nasir, L., Daunt, F., Gault, E., Croxall, J., Wanless, S. and Monaghan, P. (2004) Telomere loss in relation to age and early environment in long-lived birds. Proceedings of the Royal Society of London Series B: Biological Sciences, 271, pp. 1571-1576. (doi: 10.1098/rspb.2004.2768)

Nasir, L., Gault, E., Campbell, S., Veeramalai, M., Gilbert, D., McFarlane, R., Munro, A. and Argyle, D. (2004) Isolation and expression of the reverse transcriptase component of the Canis familiaris telomerase ribonucleoprotein (dogTERT). Gene, 336, pp. 105-113. (doi: 10.1016/j.gene.2004.03.032)

2003

Argyle, D., Ellsmore, V., Gault, E., Munro, A. and Nasir, L. (2003) Equine telomeres and telomerase in cellular immortalisation and ageing. Mechanisms of Ageing and Development, 124, pp. 759-764. (doi: 10.1016/S0047-6374(03)00104-0)

Argyle, D. and Nasir, L. (2003) Telomerase: A potential diagnostic and therapeutic tool in canine oncology. Veterinary Pathology, 40, pp. 1-7.

Chambers, G., Ellsmore, V., OBrien, P., Reid, S., Love, S., Campo, M. and Nasir, L. (2003) Association of bovine papillomavirus with the equine sarcoid. Journal of General Virology, 84, pp. 1055-1062. (doi: 10.1099/vir.0.18947-0)

Chambers, G., Ellsmore, V., OBrien, P., Reid, S., Love, S., Campo, M. and Nasir, L. (2003) Sequence variants of bovine papillomavirus E5 detected in equine sarcoids. Virus Research, 96(1,2), pp. 141-145. (doi: 10.1016/S0168-1702(03)00175-8)

McKevitt, T., Nasir, L., Wallis, C. and Argyle, D. (2003) A cohort study of telomere and telomerase biology in cats. American Journal of Veterinary Research, 64, pp. 1496-1499.

2002

Campbell, S., Sood, A., Argyle, D., Nasir, L., Argyle, S. and Bennett, D. (2002) The cloning and functional analysis of canine matrix metalloproteinase-13 gene promoter. Gene, 286, pp. 233-240.

McKevitt, T., Nasir, L., Devlin, P. and Argyle, D. (2002) Telomere lengths in dogs decrease with increasing donor age. Journal of Nutrition, 132, 1604S-1606S.

2001

Campbell, S., Nasir, L., Argyle, D. and Bennett, D. (2001) Molecular cloning and characterization of canine metalloproteinase-9 gene promoter. Gene, 273, pp. 81-87.

Campbell, S., Nasir, L., Argyle, D., Gault, E., Duthie, S. and Bennett, D. (2001) Cloning of canine IL-1ra, TNFR and TIMP-2. Veterinary Immunology and Immunopathology, 78, pp. 207-214.

Nasir, L., Devlin, P., Mckevitt, T., Rutteman, G. and Argyle, D. (2001) Telomere lengths and telomerase activity in dog tissues: A potential model system to study human telomere and telomerase biology. Neoplasia, 3, pp. 351-359.

Nasir, L., Rutteman, G., Reid, S., Schulze, C. and Argyle, D. (2001) Analysis of p53 mutational events and MM2 amplification in canine soft-tissue sarcomas. Cancer Letters, 174, pp. 83-89.

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