Dr Tansy Hammarton
- Senior Lecturer (Parasitology)
telephone:
01413306766
email:
Tansy.Hammarton@glasgow.ac.uk
RB625 Level B6, Iii - Sgdb, University Place, Glasgow G12 8TA
Biography
I am a Senior Lecturer in the School of Infection & Immunity and have a mixed academic portfolio comprising research, teaching and public engagement, as well as leadership roles in Health and Safety.
Research
My current research interests lie in parasitology, with a focus on understanding how kinetoplastid parasites such as trypanosomes and Leishmania replicate and divide. I became interested in the cell cycle of Trypanosoma brucei when I was a postdoctoral research assistant in Jeremy Mottram’s lab and discovered differences in cell cycle regulation between different life cycle stages of the parasite. I went onto obtain research fellowships from the Medical Research Council (MRC) and Research Councils UK (RCUK), followed by an MRC New Investigator Research Grant to investigate the unusual mechanism of cytokinesis in T. brucei and functionally characterise a number of protein kinases and cytoskeletal proteins essential for cell division.
More recently, my research interests have expanded to include Leishmania and other kinetoplastid parasites. Through a bioengineering collaboration with Melanie Jimenez (University of Strathclyde), we have explored microfluidic approaches to separating different parasite cell cycle stages, have developed an event-based camera approach for imaging of parasites and other particles in microfluidic channels, and have carried out studies with Leishmania parasites that have enhanced our understanding of how non-spherical particles focus in microfluidic channels. We have also developed imaging flow cytometry analysis pipelines to enhance cell cycle analysis in Leishmania mexicana, allowing easier visualisation of rare cell cycle stages and resulting in new insights into the fundamental biology of its cell division cycle.
Other current projects in the lab include investigating the evolution of the protein kinome in free-living to pathogenic trypanosomes, and investigating the protein kinase signalling networks that regulate cytokinesis in T. brucei and L. mexicana.
I also have a broader interest in microbiology, stemming from my undergraduate degree in Natural Sciences from the University of Cambridge, where I specialised in microbial and parasitic disease and virology, and carried out research on male-killing bacteria in ladybirds, and my PhD studies on the Export of Polysaccharide Capsule in Escherichia coli at the University of Manchester.
Public Engagement
I have a strong interest in public engagement, which stems from the outreach work I did as an RCUK fellow. I have been a STEM Ambassador since 2005 and over the years, have developed a range of infection biology-related activities for nursery and school pupils aged 2-18 yrs, including school visits and talks, hands-on workshops, a science club and role-playing activities as well as Continuing Professional Development sessions for teachers. I am also a member of the Microbiology in Schools Advisory Committee (MiSAC), have undertaken consultancy work for the Scottish Schools Educational Research Council (SSERC) and am an Associate Editor for the kids’ science journal, Frontiers for Young Minds. I have also taken part in a variety of events to bring science to the general public, including giving public lectures, organising conference sessions for the public and taking part in the Glasgow Science Festival and Pint of Science. I also train undergraduate and postgraduate students in Science Communication and public engagement and am active in championing public engagement activities across the School of Infection and Immunity (SII).
In 2018, my public engagement work was recognised with the award of the Peter Wildy Prize from the Microbiology Society Microbiology Society Peter Wildy Prize 2018: Dr Tansy Hammarton | Microbiology Society.
Other activities
Outside of research and public engagement, I have a strong teaching portfolio, from undergraduate to postgraduate levels, covering topics such as microbiology, parasitology, molecular biology, research skills and science communication (see teaching tab for more details). I have also undertaken numerous Health and Safety roles for the SII, and more widely for the College of Medical, Veterinary and Life Sciences (MVLS). For example, I was a member for many years and later chaired the MVLS Genetic Modification 37 committee, and I am currently Chair of the SII Health and Safety committee, a member of the SII Containment Level 3 Management Group and am one of the SII SAPO (Specified Animal Pathogens Order) representatives.
Research interests
Cell division in kinetoplastid parasites
Kinetoplastid parasites, such as the African trypanosome (Trypanosoma brucei spp.) and Leishmania spp. are vector-borne protozoan parasites which cause Neglected Tropical Diseases, so called because they disproportionately affect some of the world’s most impoverished people in tropical areas. T. brucei causes sleeping sickness (humans) and Nagana (livestock) in sub-Saharan Africa and is spread by the bite of infected tsetse flies, while Leishmania parasites cause the leishmaniases, a spectrum of diseases ranging from unsightly, and often stigmatising, skin ulcer to fatal visceral disease, and are spread by sand flies. Leishmaniasis is found in many parts of the world, including Africa, the Americas, the Eastern Mediterranean, and parts of Asia and Europe, and is spreading to new areas in response to climate change. Effective vaccines for these diseases do not exist, and there is a continuing need to extend our drug arsenal against these diseases.
Research in the Hammarton lab is focussed on understanding how these parasites replicate and divide in their hosts, and on uncovering the molecular pathways that control cell division, particularly those involving protein kinases. Protein kinases are key signalling molecules and are known to be druggable. Cell division is not only essential for kinetoplastids to multiply in their hosts but is very divergent from mammalian cell division. Understanding the essential protein kinase signalling pathways regulating cell division is likely to identify novel parasite proteins that could be specifically targeted by new drugs to cure infections. Furthermore, trypanosomes display remarkable cell biology and are useful model organisms for comparative studies with higher eukaryotes; our work on uncovering the regulatory networks involved is shedding light on the evolution of cell division in these important pathogens.
In recent years, we have also collaborated with Melanie Jimenez’s lab at the University of Strathclyde to develop and enhance technologies such as microfluidics and imaging flow cytometry to facilitate the study of the kinetoplastid cell cycle, which has provided novel insights into the fundamental biology of these organisms.
Current projects
- Functional analysis of MAK signalling pathways in trypanosomes and Leishmania
- Comparative analysis of animal trypanosome kinomes
- Signalling through the kinetoplastid cell division cycle
- Developing new technologies to facilitate the study of kinetoplastid cell division
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- ISSF Catalyst: Mapping lipid distribution in Trypanosoma brucei during cell division
Wellcome Trust
2015 - 2017
- NDR kinase pathways in bloodstream stage Trypanosoma brucei
Medical Research Council
2009 - 2013
- Regulation of cytokinesis in Trypanosoma brucei
Medical Research Council
2005 - 2009
- The development of fluorescent Trypanosoma brucei cell lines as tools for the study of the trypanosome cell division cycle
The Royal Society
2005 - 2006
- Research Councils UK Academic Fellowship
Engineering and Physical Sciences Research Council
2005 - 2010
- Cell cycle progression in the African trypanosome
Wellcome Trust
2004 - 2007
Supervision
Current PhD students
Sulochana Omwenga: Identification and validation of novel Leishmaniasis drug targets through comparative molecular analysis of individual Leishmania parasite cell cycle stages isolated using microfluidics. Funder: The Cunningham Trust. Supervisors: Tansy Hammarton and Melanie Jimenez.
Saleh Alquarni: Analysis of amino acid permeases of Leishmania. Funder: The Royal Embassy of Saudi Arabia. Supervisors: Richard Burchmore and Tansy Hammarton.
Previous PhD students
- Thesis titles, completion dates, funders, supervisors and next destinations are shown.
Olubukola Owolodun: Functional Characterisation of a Male Germ Cell-Associated Kinase Orthologue (MAK) in the Kinetoplastid Cell Cycle (2025). Funder: TetFund. Supervisors: Tansy Hammarton and Richard McCulloch. Onward destination: postdoctoral research in Emma Briggs’ lab, Newcastle University.
Jessie Howell: Using microfluidics to separate and study kinetoplastid parasites (2023). Funder: EPSRC. Supervisors: Melanie Jimenez (University of Strathclyde), Tansy Hammarton and Julien Reboud. Onward destination: postdoctoral research in Melanie Jimenez's lab, University of Strathclyde and then in Yoann Altmann's lab, Heriot-Watt University.
Bernardo Pereira Moreira: Analysis of FAZ10 in bloodstream form T. brucei. Visiting PhD student from Munira Baqui’s lab, Sao Paulo (2015-2016). Funded by CAPES. Onward destinations: postdoctoral research at University of Nottingham, FIOCRUZ and Justus Liebig University, Giessen.
Helena Maritza De la Torre Olvera: Analysis of protein kinase pathways regulating cytokinesis and endocytosis (2019). Funder: SENESCYT. Supervisors: Tansy Hammarton and Jeremy Mottram. Onward destinations: University lecturer at Universidad Laica Eloy Alfaro de Manabi and then Universidad Técnica de Ambato.
Elizabeth Thomas: Signalling pathways regulating cytokinesis in Trypanosoma brucei (2014). Funders: MRC & BBSRC. Supervisors: Tansy Hammarton and Jeremy Mottram. Onward destinations: postdoctoral research at University of Washington and Washington State University.
Cristina Costa: Generating monoclonal antibodies against Trypanosoma brucei cell cycle regulators (2012). International PhD student from Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal. Supervisors: Carlos Novo and Tansy Hammarton. Onward destination: mycology research in the food industry.
Sophie May: Regulation of cytokinesis in Trypanosoma brucei (2010). Funder: MRC. Supervisor: Tansy Hammarton. Onward destination: clinical mycologist, NHS.
Previous MSc by Research students
Glynn Forsythe: DNA damage in Trypanosoma brucei. Funder: MRC. Supervisor: Tansy Hammarton and Richard McCulloch.
Teaching
I undertake a range of undergraduate and postgraduate teaching duties, including giving lectures, leading workshops and labs, supervising dissertations and research projects, marking and examining student work, and developing and leading courses and programmes.
I am currently involved in the following teaching:
Undergraduate
- Level 2 Microbiology and Immunology – lectures, labs and assessment
- L3 Medical Microbiology – lectures, workshops, labs and assessment
- L4 Microbiology – lectures and assessment
- BSc Research Projects - supervision and assessment (various degree programmes)
- Advisor of Studies for undergraduate students
Postgraduate
MSc
- MSc in Infection Biology - Programme Director
- Research Skills in Immunology and Infection Biology - lectures and labs
- Host Pathogen Interactions - essay supervision and assessment
- Designing a Research Project – lectures and student supervision
- MSc Research Projects – supervision and assessment (various degree programmes)
- Mentor for postgraduate taught students
PhD
- PhD ‘How do I engage the public with my research’ – Course Leader
- Assessor for postgraduate research students
Previous roles have included Level 1 teaching, coordinating Level 2 microbiology, leading Level 3 tutorials and working with Head of College Scholars' List students.
Professional activities & recognition
Prizes, awards & distinctions
- 2018: Peter Wildy Prize (Microbiology Society)
- 2011: Finalist in UK awards "Most dedicated STEM Ambassador" category (STEMNet UK)
- 2011: Partnership grant 'Microbiology in the Media - don't believe everything you read!' in partnership with Miss Jenny Hewitt, Hillhead High School, Glasgow (Royal Society)
Research fellowships
- 2005 - 2009: MRC Career Development Fellowship
- 2005 - 2010: Research Councils UK Academic Fellowship
Grant committees & research advisory boards
- 2022 - 2027: Royal Society, International Exchanges Panel
Editorial boards
- 2018 - present: Frontiers for Young Minds. Associate Editor - Understanding Health section
- 2015 - 2017: Eukaryotic Cell. Editorial Board
Professional & learned societies
- 2021 - present: Member, Microbiology Society
- 2009 - present: Fellow, Higher Education Academy
- 2007 - 2020: Member, Biochemical Society
- 1999 - present: Member, British Society for Parasitology
Selected international presentations
- 2022: Invited seminar (Biozentrum, Universität Würzburg)
- 2016: Invited talk, Trypanosomatid parasites - from the field to the lab IV. 'Regulation of cytokinesis in Trypanosoma brucei' (Institut Pasteur, Paris, France)
- 2011: Plenary talk, IX Argentinean Congress of Protozoology and Parasitic Diseases. 'Cytokinesis in Trypanosoma brucei - some insights in to how trypanosomes divide'. (Mar del Plata, Argentina)
- 2011: Invited talk, Kinetoplastid Molecular Cell Biology Meeting IV. 'The complexities of cell division in Trypanosoma brucei.' (Woods Hole, Massachussets, USA)
- 2010: 3rd Conference on Protein Kinases of Parasitic Protozoa. 'Regulation and function of NDR kinases in Trypanosoma brucei' (Lausanne, Switzerland)
- 2009: Microbiologie Cellulaire et Moleculaire et Pathogenicite Dept. 'Cell division in the African trypanosome' (University of Bordeaux, France)
- 2006: COST Action B22 meeting, University of Glasgow. 'Protein kinases involved in cell proliferation: differentiation and homeostasis: targets for anti-protozoal chemotherapy' (University of Glasgow, Scotland)
- 2004: Invited seminar (Dept. of Biochemistry, Melbourne University, Australia)
Supplementary
- 2024 Member of Microbiology Society Prize Award Panel 2021-present Microbiology Society representative on the Microbiology in Schools Advisory Committee
