Professor Ruth Jarrett

  • Professor of Molecular Pathology (Centre for Virus Research)
  • Associate Academic (School of Veterinary Medicine)
  • Associate Academic (Institute of Cancer Sciences)

telephone: 01413305775
email: Ruth.Jarrett@glasgow.ac.uk

Research interests

CVR logo

Our group has a longstanding interest in the role of viruses in human leukaemia and lymphoma.

Much of our research is focused on Hodgkin lymphoma, one of the commonest malignancies affecting young adults. A proportion of cases of Hodgkin lymphoma, around one third in developed countries, are associated with the Epstein-Barr virus (EBV) and this association is thought to be causal.  Epidemiological data suggest that non-EBV-associated Hodgkin lymphoma may be associated with delayed exposure to a common infectious agent(s) and we believe that another virus may be involved in the pathogenesis of this group of cases.

We are currently using next generation sequencing to search for novel viral sequences in tumour cells enriched from biopsy samples from these cases. Recent work from our group, including collaborative Genome Wide Association Studies, provides clear evidence that host genetics influences risk of Hodgkin lymphoma. In particular, HLA genotype modifies disease risk. Genetic risk factors for EBV-associated and non-associated Hodgkin lymphoma are largely distinct, providing further evidence that these two forms of the disease have different natural histories.

Ongoing work is exploring the biology underlying these associations and determining their clinical significance. We are also investigating biomarkers that appear promising both in the early diagnosis of Hodgkin lymphoma and for assessing response to treatment.

Other interests include:

  • virus discovery in a broader range of diseases of human and animals including canine lymphoma;
  • the significance of germline transmitted, chromosomally integrated human herpesvirus-6;
  • non-viral aspects of the pathogenesis of Hodgkin lymphoma.

I am also an Honorary Consultant, Department of Pathology, NHSGGC

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Development of a point-of-care test for CCL17 (TARC) to improve risk-adapted therapy in classical Hodgkin lymphoma.
    Scottish Executive Health Department
    2015 - 2016
     
  • The Centre for Virus Research
    Wellcome Trust
    2015 - 2020
     
  • Investigation of the mechanism by which HLA class I genotype influences risk of EBV-associated Hodgkin lymphoma
    Leukaemia & Lymphoma Research
    2014 - 2015
     
  • Optimising therapeutic vaccination against Epstein-Barr virus(EBV): complementing existing strategies with dendritic cell (DC) targeted vaccines.
    Cancer Research UK
    2014 - 2016
     
  • Hodgkin lymphoma, HLA and infectious mononucleosis: how do HLA risk alleles and prior infectious mononucleosis lead to an increased risk of EBV-associated Hodgkin lymphoma.
    The Kay Kendall Leukaemia Fund
    2014 - 2015
     
  • Classification of B cell canine lymphomas using deep sequencing for gene expression
    European College of Veterinary Internal Medicine
    2013 - 2014
     
  • Hodgkin lymphoma, HLA and infectious mononucleosis: how do HLA risk alleles and prior infectious mononucleosis lead to an increased risk of EBV-associated Hodgkin lymphoma.
    The Kay Kendall Leukaemia Fund
    2012 - 2014
     
  • Development of a resource for the investigation of lymphoma, with a focus on Hodgkin lymphoma.
    Leukaemia & Lymphoma Research
    2012 - 2014
     
  • Investigation of the pathogenesis of Hodgkin lymphoma
    Leukaemia & Lymphoma Research
    2011 - 2012
     
  • Investigation of the biological basis and clinical correlates of the association between EBV-associated Hodgkin lymphoma and HLA class I genotype
    Royal College of Physicians & Surgeons of Glasgow
    2011 - 2012
     
  • Can p62 expression be exploited for targeted chemotherapy in Hodgkin lymphoma?
    Scottish Executive Health Department
    2010 - 2012
     
  • Centre for Integrated Virology
    MRC
    2010 - 2015
     
  • Investigation of the mechanism by which HLA class I genotype influences risk of EBV-associated Hodgkin lymphoma
    Leukaemia & Lymphoma Research
    2010 - 2015
     
  • A pilot study to investigate the potential usefulness of plasma TARC (CCL17) in the early diagnosis of Hodgkin's Lymphoma
    Scottish Executive Health Department
    2009 - 2010
     
  • Investigation of the biological basis and clinical correlates of the association between EBV-associated Hodgkin lymphoma and HLA class I genotype
    The Kay Kendall Leukaemia Fund
    2009 - 2012
     
  • Investigation of the pathogenesis of Hodgkin lymphoma
    Leukaemia & Lymphoma Research
    2008 - 2011
     
  • Viruses and common acute lymphoblastic leukaemia: investigation of the involvement of viruses with small DNA genomes
    The Kay Kendall Leukaemia Fund
    2007 - 2009
     
  • LRF bank of viable lymph node cells
    Leukaemia & Lymphoma Research
    2006 - 2008
     
  • A randomised controlled trial of the efficacy of prophylatic aciclovir in prevention of herpes simplex virus infections in intensive therapy
    Scottish Executive Health Department
    2006 - 2010
     
  • Investigation of the pathogenesis of Hodgkin lymphoma
    Leukaemia & Lymphoma Research
    2005 - 2008
     
  • Investigation of recurrent chromosomal imbalances in Hodgkin lymphoma using a CGH microarray system
    Leukaemia & Lymphoma Research
    2003 - 2008
     
  • LRF Virus Centre - programme 1: Virus Identification Programme
    Leukaemia & Lymphoma Research
    2000 - 2005
     
  • LRF Virus Centre - Programme 2: Hodgkin's Disease Pathogenesis
    Leukaemia & Lymphoma Research
    2000 - 2005
     

Additional information

Editorial Board

  • 2004 - ongoing: International Journal of Cancer
  • 2000 - 2004: Journal of Human Virology

Grant Advisory Board

  • 2005 - 2010: Grant Committee
  • 2004 - 2013: Chief Scientist Office (CSO) - ETMR (prev BTRC)

Invited International Presentations

  • 2013: Cologne, Germany - Invited speaker, 9th International Symposium on Hodgkin lymphoma
  • 2013: Dijon, France - Invited speaker, Interlymphs Consortium Annual Meeting
  • 2013: Dublin, Ireland - Invited speaker, International Workshop on Non-Hodgkin Lymphoma
  • 2012: Bethesda, MD, USA - Invited speaker, Interlymphs Consortium Annual Meeting
  • 2011: Glasgow, UK - European Society of Veterinary Oncology
  • 2010: Bethesda, MD, USA - Interlymphs Consortium Annual Meeting
  • 2010: New York, NY, USA - International Workshop on non-Hodgkin lymphoma
  • 2010: Stockholm, Sweden - Invited seminar at Karolinska Institute
  • 2009: Abu Dhabi, United Arab Emirates - Progress in Pathology
  • 2009: Luxembourg - European Commission Symposium on Childhood Leukaemia
  • 2009: Vancouver, BC, Canada - Interlymphs Consortium Annual Meeting
  • 2008: Sydney, Australia - Interlymphs Consortium Annual Meeting
  • 2007: Sausalito, CA, USA - Childhood Leukaemia Consortium
  • 2007: Cologne, Germany - 7th International Symposium on Hodgkin Lymphoma

Prizes, Awards and Distinctions

  • 2007: Royal Society of Edinburgh - Elected Fellow

Professional Learned Society

  • 2009 - 2012: Royal Society of Edinburgh - Convener A2 Sectional Committee

Publications

List by: Type | Date

Jump to: 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
Number of items: 49.

2016

Zhang, E. et al. (2016) HHV-8-unrelated primary effusion-like lymphoma associated with clonal loss of inherited chromosomally-integrated human herpesvirus 6A from the telomere of chromosome 19q. Scientific Reports, 6, 22730. (doi:10.1038/srep22730) (PMID:26947392) (PMCID:PMC4779988)

2015

Khankhanian, P. et al. (2015) Meta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis. International Journal of Epidemiology, (doi:10.1093/ije/dyv364) (PMID:26971321) (Early Online Publication)

Waugh, E. M., Gallagher, A., McAulay, K., Henriques, J., Alves, M., Bell, A. J., Morris, J. S., and Jarrett, R. F. (2015) Gammaherpesviruses and canine lymphoma: no evidence for direct involvement in commonly occurring lymphomas. Journal of General Virology, 96, pp. 1863-1872. (doi:10.1099/vir.0.000106) (PMID:25722346)

Johnson, P. C.D. et al. (2015) Modeling HLA associations with EBV-positive and -negative Hodgkin lymphoma suggests distinct mechanisms in disease pathogenesis. International Journal of Cancer, 137(5), pp. 1066-1075. (doi:10.1002/ijc.29467) (PMID:25648508)

2014

Bell, A. J., Gallagher, A., Mottram, T., Lake, A., Kane, E. V., Lightfoot, T., Roman, E., and Jarrett, R. F. (2014) Germ-line transmitted, chromosomally integrated hhv-6 and classical Hodgkin lymphoma. PLoS ONE, 9(11), e112642. (doi:10.1371/journal.pone.0112642)

Cozen, W. et al. (2014) A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. Nature Communications, 5(3856), (doi:10.1038/ncomms4856)

2013

Frampton, M. et al. (2013) Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s lymphoma. Nature Communications, 4(2549), (doi:10.1038/ncomms3549)

Jarrett, R. F., Gallagher, A., and Gatherer, D. (2013) Molecular methods of virus detection in lymphoma. In: Küppers, R. (ed.) Lymphoma: Methods and Protocols. Series: Methods in Molecular Biology (971). Humana Press, pp. 277-293. ISBN 9781627032681 (doi:10.1007/978-1-62703-269-8_16)

2012

Urayama, K. Y. et al. (2012) Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups. Journal of the National Cancer Institute, 104(3), pp. 240-253. (doi:10.1093/jnci/djr516)

Haniffa, M. et al. (2012) Human tissues contain CD141hi cross-presenting Dendritic cells with functional homology to mouse CD103+ nonlymphoid Dendritic cells. Immunity, 37(1), pp. 60-73. (doi:10.1016/j.immuni.2012.04.012)

2011

Farrell, K., and Jarrett, R.F. (2011) The molecular pathogenesis of Hodgkin lymphoma. Histopathology, 58(1), pp. 15-25. (doi:10.1111/j.1365-2559.2010.03705.x)

Waugh, E.M., Jarrett, R.F., Shield, L., Montgomery, D., Dean, R.T.G., Mitchell, A., Greaves, M. F., and Gallagher, A. (2011) The retrovirus XMRV is not directly involved in the pathogenesis of common types of lymphoid malignancy. Cancer Epidemiology, Biomarkers and Prevention, 20(10), pp. 2232-2236. (doi:10.1158/1055-9965.EPI-11-0561)

2010

Enciso-Mora, V. et al. (2010) A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). Nature Genetics, 42(12), pp. 1126-1130. (doi:10.1038/ng.696)

Hjalgrim, H. et al. (2010) HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma. Proceedings of the National Academy of Sciences of the United States of America, 107(14), pp. 6400-6405. (doi:10.1073/pnas.0915054107)

Friborg, J. T., Jarrett, R.F., Koch, A., Garred, P., Freeland, J. M. L., Andersen, A., and Melbye, M. (2010) Mannose-Binding Lectin Genotypes and Susceptibility to Epstein-Barr Virus Infection in Infancy. Clinical and Vaccine Immunology, 17(9), pp. 1484-1487. (doi:10.1128/CVI.00527-09)

2009

Lake, A. et al. (2009) Mutations of NFKBIA, encoding I kappa B alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases. International Journal of Cancer, 125(6), pp. 1334-1342. (doi:10.1002/ijc.24502)

Machado, L. et al. (2009) Expression and function of T cell homing molecules in Hodgkin's lymphoma. Cancer Immunology Immunotherapy, 58(1), pp. 85-94. (doi:10.1007/s00262-008-0528-z [Machado, Lee; Morgan, Susan; Murray, Paul; Hunter, Beatrix; Hamilton, Emma; Thomas, Wendy; Steven, Neil; Chapman, Ann; Lee, Steven P.] Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England. [Jar)

2007

Wilson, K.S., Freeland, J.M.L., Gallagher, A., Cosby, S.L., Earle, J.A.P., Alexander, F.E., Taylor, G.M., and Jarrett, R.F. (2007) Measles virus and classical Hodgkin lymphoma: No evidence for a direct association. International Journal of Cancer, 121(2), pp. 442-447. (doi:10.1002/ijc.22629)

Friborg, J., Jarrett, R., Liu, M., Falk, K., Koch, A., Olsen, O., Duncan, P., Wohlfarht, J., Chen, J., and Melbye, M. (2007) Epstein-Barr virus immune response in high-risk nasopharyngeal carcinoma families in Greenland. Journal of Medical Virology, 79, pp. 1877-1881. (doi:10.1002/jmv.21014)

McAulay, K., Higgins, C., Macsween, K., Lake, A., Jarrett, R., Robertson, F., Williams, H., and Crawford, D. (2007) HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection. Journal of Clinical Investigation, 117, pp. 3042-3048. (doi:10.1172/JCI32377)

2006

Niens, M., van den Berg, A., Diepstra, A., Nolte, I.M., van der Steege, G., Gallagher, A., Taylor, G.M., Jarrett, R.F., Poppema, S., and Meerman, G.J.T. (2006) The human leukocyte antigen class I region is associated with EBV-positive Hodgkin's lymphoma: HLA-A and HLA complex group 9 are putative candidate genes. Cancer Epidemiology, Biomarkers and Prevention, 15(11), pp. 2280-2284. (doi:10.1158/1055-9965.EPI-06-0476)

Jarrett, R., Johnson, D., Wilson, K.S., and Gallagher, A. (2006) Molecular methods for virus discovery. Developments in Biologicals, 123, pp. 119-132.

Jarrett, R. (2006) Viruses and lymphoma/leukaemia. Journal of Pathology, 208, pp. 176-186. (doi:10.1002/path.1905)

MacKenzie, J., Greaves, M.F., Eden, T.O.B., Clayton, R.A., Perry, J., Wilson, K.S., and Jarrett, R.F. (2006) The putative role of transforming viruses in childhood acute lymphoblastic leukemia. Haematologica: The Hematology Journal, 91, pp. 240-243.

Wilson, K.S., Gallagher, A., Freeland, J.M.L., Shield, L.A., and Jarrett, R.F. (2006) Viruses and Hodgkin lymphoma: No evidence of polyomavirus genomes in tumor biopsies. Leukemia and Lymphoma, 47(7), pp. 1315-1321. (doi:10.1080/10428190500525789)

2005

Cordano, P., Lake, A., Shield, L., Taylor, G., Alexander, F., Taylor, P., White, J., and Jarrett, R. (2005) Effect of IL-6 promoter polymorphism on incidence and outcome in Hodgkin's lymphoma. British Journal of Haematology, 128, pp. 493-495. (doi:10.1111/j.1365-2141.2004.05353.x)

Jarrett, R., Stark, G., White, J., Angus, B., Alexander, F., Krajewski, A., Freeland, J., Taylor, G., and Taylor, P. (2005) Impact of tumor Epstein-Barr virus status on presenting features and outcome in age-defined subgroups of patients with classic Hodgkin lymphoma: a population-based study. Blood, 106, pp. 2444-2451. (doi:10.1182/blood-2004-09-3759)

Khan, G., Lake, A., Shield, L., Freeland, J., Andrew, L., Alexander, F., Jackson, R., Taylor, P., McCruden, E., and Jarrett, R. (2005) Phenotype and frequency of Epstein-Barr virus-infected cells in pretreatment blood samples from patients with Hodgkin lymphoma. British Journal of Haematology, 129, pp. 511-519. (doi:10.1111/j.1365-2141.2005.05483.x)

Osborne, J., Lake, A., Alexander, F., Taylor, G., and Jarrett, R. (2005) Germline mutations and polymorphisms in the NFKBIA gene in Hodgkin lymphoma. International Journal of Cancer, 116, pp. 646-651. (doi:10.1002/ijc.21036)

2004

Barwell, N., Howatson, R., Jackson, R., Johnson, A., Jarrett, R., and Cook, G. (2004) Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid tissue not associated with HHV-8 or EBV infection. Journal of Clinical Pathology, 57, pp. 87-89.

Jarrett, R. (2004) Epstein-Barr virus-related nasal and cutaneous T-cell lymphoma in an immunosuppressed patient. British Journal of Haematology, 125(3), p. 266.

2003

Gallagher, A., Perry, J., Freeland, J., Alexander, F.E., Carman, W.F., Shield, L., Cartwright, R., and Jarrett, R.F. (2003) Hodgkin lymphoma and Epstein-Barr virus (EBV): No evidence to support hit-and-run mechanism in cases classified as non-EBV-associated. International Journal of Cancer, 104(5), pp. 624-630. (doi:10.1002/ijc.10979)

Alexander, F., Lawrence, D., Freeland, J., Krajewski, A., Angus, B., Taylor, G., and Jarrett, R. (2003) An epidemiologic study of index and family infectious mononucleosis and adult Hodgkin's disease (HD): Evidence for a specific association with EBV+ve HD in young adults. International Journal of Cancer, 107, pp. 298-302. (doi:10.1002/ijc.11156)

Chui, D., Hammond, D., Baird, M., Shield, L., Jackson, R., and Jarrett, R. (2003) Classical Hodgkin lymphoma is associated with frequent gains of 17q. Genes Chromosomes and Cancer, 38, pp. 126-136. (doi:10.1002/gcc.10266)

Jarrett, R. (2003) Risk factors for Hodgkin's lymphoma by EBV status and significance of detection of EBV genomes in serum of patients with EBV-associated Hodgkin's lymphoma. Leukemia and Lymphoma, 44, S27-S32. (doi:10.1080/10428190310001623801)

Jarrett, R., Krajewski, A., Angus, B., Freeland, J., Taylor, P., Taylor, G., and Alexander, F. (2003) The Scotland and Newcastle epidemiological study of Hodgkin's disease: impact of histopathological review and EBV status on incidence estimates. Journal of Clinical Pathology, 56, pp. 811-816.

MacKenzie, J., Wilson, K.S., Perry, J., Gallagher, A., and Jarrett, R.F. (2003) Association between simian virus 40 DNA and lymphoma in the United Kingdom. Journal of the National Cancer Institute, 95(13), pp. 1001-1003.

2002

Gallagher, A., Perry, J., Shield, L., Freeland, J., MacKenzie, J., and Jarrett, R.F. (2002) Viruses and Hodgkin disease: No evidence of novel herpesviruses in non-EBV-associated lesions. International Journal of Cancer, 101(3), pp. 259-264. (doi:10.1002/ijc.10603)

Hew, W., Carey, F., Kernohan, N., Heppleston, A., Jackson, R., and Jarrett, R. (2002) Primary T cell lymphoma of salivary gland: a report of a case and review of the literature. Journal of Clinical Pathology, 55, pp. 61-63.

Jarrett, R. (2002) Viruses and Hodgkin's lymphoma. Annals of Oncology, 13, pp. 23-29. (doi:10.1093/annonc/mdf603)

McInnes, E., Jarrett, R., Langford, G., Atkinson, C., Horsley, J., Goddard, M., Cozzi, E., and Schuurman, H. (2002) Posttransplant lymphoproliferative disorder associated with primate gamma-herpesvirus in cynomolgus monkeys used in pig-to-primate renal xenotransplantation and primate renal allotransplantation. Transplantation, 73, pp. 44-52.

Proctor, S., Rueffer, J., Angus, B., Breuer, K., Flechtner, H., Jarrett, R., Levis, A., Taylor, P., and Tirelli, U. (2002) Hodgkin's disease in the elderly: current status and future directions. Annals of Oncology, 13, pp. 133-137. (doi:10.1093/annonc/mdf627)

2001

MacKenzie, J., Gallagher, A., Clayton, R.A., Perry, J., Eden, O.B., Ford, A.M., Greaves, M.F., and Jarrett, R.F. (2001) Screening for herpesvirus genomes in common acute lymphoblastic leukemia. Leukemia, 15(3), pp. 415-421.

Alexander, F.E., Jarrett, R.F., Cartwright, R.A., Armstrong, A.A., Gokhale, D.A., Kane, E., Gray, D., Lawrence, D.J., and Taylor, G.M. (2001) Epstein-Barr virus and HLA-DPB1-*0301 in young adult Hodgkin's disease: Evidence for inherited susceptibility to Epstein-Barr virus in cases that are EBV+ve. Cancer Epidemiology, Biomarkers and Prevention, 10, pp. 705-709.

Bates, I., Bedu-Addo, G., Jarrett, R., Schulz, T., Wallace, S., Armstrong, A., Sheldon, J., and Rutherford, T. (2001) B-lymphotropic viruses in a novel tropical splenic lymphoma. British Journal of Haematology, 112, pp. 161-166.

Chapman, A., Rickinson, A., Thomas, W., Jarrett, R., Crocker, J., and Lee, S. (2001) Epstein-Barr virus-specific cytotoxic T lymphocyte responses in the blood and tumor site of Hodgkin's disease patients: Implications for a T-cell-based therapy. Cancer Research, 61, pp. 6219-6226.

Ferrari, M., Rivadeneira, E., Jarrett, R., Stevceva, L., Takemoto, S., Markham, P., and Franchini, G. (2001) HVMNE, a novel lymphocryptovirus related to Epstein-Barr virus, induces lymphoma in New Zealand White rabbits. Blood, 98, pp. 2193-2199.

Jarrett, R., Osborne, J., Wilson, K., Aillet, F., Hay, R., and MacKenzie, J. (2001) Gene expression profiling in Hodgkin's disease-derived cell lines: Effect of NF-kappa B inhibition. Blood, 98, p. 4317.

MacKenzie, J., and Jarrett, R. (2001) A study of global gene expression in Hodgkin's disease derived cell lines using gene microarrays. Leukemia and Lymphoma, 42, p. 12.

This list was generated on Fri Jun 24 14:04:12 2016 BST.
Number of items: 49.

Articles

Zhang, E. et al. (2016) HHV-8-unrelated primary effusion-like lymphoma associated with clonal loss of inherited chromosomally-integrated human herpesvirus 6A from the telomere of chromosome 19q. Scientific Reports, 6, 22730. (doi:10.1038/srep22730) (PMID:26947392) (PMCID:PMC4779988)

Khankhanian, P. et al. (2015) Meta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis. International Journal of Epidemiology, (doi:10.1093/ije/dyv364) (PMID:26971321) (Early Online Publication)

Waugh, E. M., Gallagher, A., McAulay, K., Henriques, J., Alves, M., Bell, A. J., Morris, J. S., and Jarrett, R. F. (2015) Gammaherpesviruses and canine lymphoma: no evidence for direct involvement in commonly occurring lymphomas. Journal of General Virology, 96, pp. 1863-1872. (doi:10.1099/vir.0.000106) (PMID:25722346)

Johnson, P. C.D. et al. (2015) Modeling HLA associations with EBV-positive and -negative Hodgkin lymphoma suggests distinct mechanisms in disease pathogenesis. International Journal of Cancer, 137(5), pp. 1066-1075. (doi:10.1002/ijc.29467) (PMID:25648508)

Bell, A. J., Gallagher, A., Mottram, T., Lake, A., Kane, E. V., Lightfoot, T., Roman, E., and Jarrett, R. F. (2014) Germ-line transmitted, chromosomally integrated hhv-6 and classical Hodgkin lymphoma. PLoS ONE, 9(11), e112642. (doi:10.1371/journal.pone.0112642)

Cozen, W. et al. (2014) A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. Nature Communications, 5(3856), (doi:10.1038/ncomms4856)

Frampton, M. et al. (2013) Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s lymphoma. Nature Communications, 4(2549), (doi:10.1038/ncomms3549)

Urayama, K. Y. et al. (2012) Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups. Journal of the National Cancer Institute, 104(3), pp. 240-253. (doi:10.1093/jnci/djr516)

Haniffa, M. et al. (2012) Human tissues contain CD141hi cross-presenting Dendritic cells with functional homology to mouse CD103+ nonlymphoid Dendritic cells. Immunity, 37(1), pp. 60-73. (doi:10.1016/j.immuni.2012.04.012)

Farrell, K., and Jarrett, R.F. (2011) The molecular pathogenesis of Hodgkin lymphoma. Histopathology, 58(1), pp. 15-25. (doi:10.1111/j.1365-2559.2010.03705.x)

Waugh, E.M., Jarrett, R.F., Shield, L., Montgomery, D., Dean, R.T.G., Mitchell, A., Greaves, M. F., and Gallagher, A. (2011) The retrovirus XMRV is not directly involved in the pathogenesis of common types of lymphoid malignancy. Cancer Epidemiology, Biomarkers and Prevention, 20(10), pp. 2232-2236. (doi:10.1158/1055-9965.EPI-11-0561)

Enciso-Mora, V. et al. (2010) A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). Nature Genetics, 42(12), pp. 1126-1130. (doi:10.1038/ng.696)

Hjalgrim, H. et al. (2010) HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma. Proceedings of the National Academy of Sciences of the United States of America, 107(14), pp. 6400-6405. (doi:10.1073/pnas.0915054107)

Friborg, J. T., Jarrett, R.F., Koch, A., Garred, P., Freeland, J. M. L., Andersen, A., and Melbye, M. (2010) Mannose-Binding Lectin Genotypes and Susceptibility to Epstein-Barr Virus Infection in Infancy. Clinical and Vaccine Immunology, 17(9), pp. 1484-1487. (doi:10.1128/CVI.00527-09)

Lake, A. et al. (2009) Mutations of NFKBIA, encoding I kappa B alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases. International Journal of Cancer, 125(6), pp. 1334-1342. (doi:10.1002/ijc.24502)

Machado, L. et al. (2009) Expression and function of T cell homing molecules in Hodgkin's lymphoma. Cancer Immunology Immunotherapy, 58(1), pp. 85-94. (doi:10.1007/s00262-008-0528-z [Machado, Lee; Morgan, Susan; Murray, Paul; Hunter, Beatrix; Hamilton, Emma; Thomas, Wendy; Steven, Neil; Chapman, Ann; Lee, Steven P.] Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England. [Jar)

Wilson, K.S., Freeland, J.M.L., Gallagher, A., Cosby, S.L., Earle, J.A.P., Alexander, F.E., Taylor, G.M., and Jarrett, R.F. (2007) Measles virus and classical Hodgkin lymphoma: No evidence for a direct association. International Journal of Cancer, 121(2), pp. 442-447. (doi:10.1002/ijc.22629)

Friborg, J., Jarrett, R., Liu, M., Falk, K., Koch, A., Olsen, O., Duncan, P., Wohlfarht, J., Chen, J., and Melbye, M. (2007) Epstein-Barr virus immune response in high-risk nasopharyngeal carcinoma families in Greenland. Journal of Medical Virology, 79, pp. 1877-1881. (doi:10.1002/jmv.21014)

McAulay, K., Higgins, C., Macsween, K., Lake, A., Jarrett, R., Robertson, F., Williams, H., and Crawford, D. (2007) HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection. Journal of Clinical Investigation, 117, pp. 3042-3048. (doi:10.1172/JCI32377)

Niens, M., van den Berg, A., Diepstra, A., Nolte, I.M., van der Steege, G., Gallagher, A., Taylor, G.M., Jarrett, R.F., Poppema, S., and Meerman, G.J.T. (2006) The human leukocyte antigen class I region is associated with EBV-positive Hodgkin's lymphoma: HLA-A and HLA complex group 9 are putative candidate genes. Cancer Epidemiology, Biomarkers and Prevention, 15(11), pp. 2280-2284. (doi:10.1158/1055-9965.EPI-06-0476)

Jarrett, R., Johnson, D., Wilson, K.S., and Gallagher, A. (2006) Molecular methods for virus discovery. Developments in Biologicals, 123, pp. 119-132.

Jarrett, R. (2006) Viruses and lymphoma/leukaemia. Journal of Pathology, 208, pp. 176-186. (doi:10.1002/path.1905)

MacKenzie, J., Greaves, M.F., Eden, T.O.B., Clayton, R.A., Perry, J., Wilson, K.S., and Jarrett, R.F. (2006) The putative role of transforming viruses in childhood acute lymphoblastic leukemia. Haematologica: The Hematology Journal, 91, pp. 240-243.

Wilson, K.S., Gallagher, A., Freeland, J.M.L., Shield, L.A., and Jarrett, R.F. (2006) Viruses and Hodgkin lymphoma: No evidence of polyomavirus genomes in tumor biopsies. Leukemia and Lymphoma, 47(7), pp. 1315-1321. (doi:10.1080/10428190500525789)

Cordano, P., Lake, A., Shield, L., Taylor, G., Alexander, F., Taylor, P., White, J., and Jarrett, R. (2005) Effect of IL-6 promoter polymorphism on incidence and outcome in Hodgkin's lymphoma. British Journal of Haematology, 128, pp. 493-495. (doi:10.1111/j.1365-2141.2004.05353.x)

Jarrett, R., Stark, G., White, J., Angus, B., Alexander, F., Krajewski, A., Freeland, J., Taylor, G., and Taylor, P. (2005) Impact of tumor Epstein-Barr virus status on presenting features and outcome in age-defined subgroups of patients with classic Hodgkin lymphoma: a population-based study. Blood, 106, pp. 2444-2451. (doi:10.1182/blood-2004-09-3759)

Khan, G., Lake, A., Shield, L., Freeland, J., Andrew, L., Alexander, F., Jackson, R., Taylor, P., McCruden, E., and Jarrett, R. (2005) Phenotype and frequency of Epstein-Barr virus-infected cells in pretreatment blood samples from patients with Hodgkin lymphoma. British Journal of Haematology, 129, pp. 511-519. (doi:10.1111/j.1365-2141.2005.05483.x)

Osborne, J., Lake, A., Alexander, F., Taylor, G., and Jarrett, R. (2005) Germline mutations and polymorphisms in the NFKBIA gene in Hodgkin lymphoma. International Journal of Cancer, 116, pp. 646-651. (doi:10.1002/ijc.21036)

Barwell, N., Howatson, R., Jackson, R., Johnson, A., Jarrett, R., and Cook, G. (2004) Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid tissue not associated with HHV-8 or EBV infection. Journal of Clinical Pathology, 57, pp. 87-89.

Jarrett, R. (2004) Epstein-Barr virus-related nasal and cutaneous T-cell lymphoma in an immunosuppressed patient. British Journal of Haematology, 125(3), p. 266.

Gallagher, A., Perry, J., Freeland, J., Alexander, F.E., Carman, W.F., Shield, L., Cartwright, R., and Jarrett, R.F. (2003) Hodgkin lymphoma and Epstein-Barr virus (EBV): No evidence to support hit-and-run mechanism in cases classified as non-EBV-associated. International Journal of Cancer, 104(5), pp. 624-630. (doi:10.1002/ijc.10979)

Alexander, F., Lawrence, D., Freeland, J., Krajewski, A., Angus, B., Taylor, G., and Jarrett, R. (2003) An epidemiologic study of index and family infectious mononucleosis and adult Hodgkin's disease (HD): Evidence for a specific association with EBV+ve HD in young adults. International Journal of Cancer, 107, pp. 298-302. (doi:10.1002/ijc.11156)

Chui, D., Hammond, D., Baird, M., Shield, L., Jackson, R., and Jarrett, R. (2003) Classical Hodgkin lymphoma is associated with frequent gains of 17q. Genes Chromosomes and Cancer, 38, pp. 126-136. (doi:10.1002/gcc.10266)

Jarrett, R. (2003) Risk factors for Hodgkin's lymphoma by EBV status and significance of detection of EBV genomes in serum of patients with EBV-associated Hodgkin's lymphoma. Leukemia and Lymphoma, 44, S27-S32. (doi:10.1080/10428190310001623801)

Jarrett, R., Krajewski, A., Angus, B., Freeland, J., Taylor, P., Taylor, G., and Alexander, F. (2003) The Scotland and Newcastle epidemiological study of Hodgkin's disease: impact of histopathological review and EBV status on incidence estimates. Journal of Clinical Pathology, 56, pp. 811-816.

MacKenzie, J., Wilson, K.S., Perry, J., Gallagher, A., and Jarrett, R.F. (2003) Association between simian virus 40 DNA and lymphoma in the United Kingdom. Journal of the National Cancer Institute, 95(13), pp. 1001-1003.

Gallagher, A., Perry, J., Shield, L., Freeland, J., MacKenzie, J., and Jarrett, R.F. (2002) Viruses and Hodgkin disease: No evidence of novel herpesviruses in non-EBV-associated lesions. International Journal of Cancer, 101(3), pp. 259-264. (doi:10.1002/ijc.10603)

Hew, W., Carey, F., Kernohan, N., Heppleston, A., Jackson, R., and Jarrett, R. (2002) Primary T cell lymphoma of salivary gland: a report of a case and review of the literature. Journal of Clinical Pathology, 55, pp. 61-63.

Jarrett, R. (2002) Viruses and Hodgkin's lymphoma. Annals of Oncology, 13, pp. 23-29. (doi:10.1093/annonc/mdf603)

McInnes, E., Jarrett, R., Langford, G., Atkinson, C., Horsley, J., Goddard, M., Cozzi, E., and Schuurman, H. (2002) Posttransplant lymphoproliferative disorder associated with primate gamma-herpesvirus in cynomolgus monkeys used in pig-to-primate renal xenotransplantation and primate renal allotransplantation. Transplantation, 73, pp. 44-52.

Proctor, S., Rueffer, J., Angus, B., Breuer, K., Flechtner, H., Jarrett, R., Levis, A., Taylor, P., and Tirelli, U. (2002) Hodgkin's disease in the elderly: current status and future directions. Annals of Oncology, 13, pp. 133-137. (doi:10.1093/annonc/mdf627)

MacKenzie, J., Gallagher, A., Clayton, R.A., Perry, J., Eden, O.B., Ford, A.M., Greaves, M.F., and Jarrett, R.F. (2001) Screening for herpesvirus genomes in common acute lymphoblastic leukemia. Leukemia, 15(3), pp. 415-421.

Alexander, F.E., Jarrett, R.F., Cartwright, R.A., Armstrong, A.A., Gokhale, D.A., Kane, E., Gray, D., Lawrence, D.J., and Taylor, G.M. (2001) Epstein-Barr virus and HLA-DPB1-*0301 in young adult Hodgkin's disease: Evidence for inherited susceptibility to Epstein-Barr virus in cases that are EBV+ve. Cancer Epidemiology, Biomarkers and Prevention, 10, pp. 705-709.

Bates, I., Bedu-Addo, G., Jarrett, R., Schulz, T., Wallace, S., Armstrong, A., Sheldon, J., and Rutherford, T. (2001) B-lymphotropic viruses in a novel tropical splenic lymphoma. British Journal of Haematology, 112, pp. 161-166.

Chapman, A., Rickinson, A., Thomas, W., Jarrett, R., Crocker, J., and Lee, S. (2001) Epstein-Barr virus-specific cytotoxic T lymphocyte responses in the blood and tumor site of Hodgkin's disease patients: Implications for a T-cell-based therapy. Cancer Research, 61, pp. 6219-6226.

Ferrari, M., Rivadeneira, E., Jarrett, R., Stevceva, L., Takemoto, S., Markham, P., and Franchini, G. (2001) HVMNE, a novel lymphocryptovirus related to Epstein-Barr virus, induces lymphoma in New Zealand White rabbits. Blood, 98, pp. 2193-2199.

Jarrett, R., Osborne, J., Wilson, K., Aillet, F., Hay, R., and MacKenzie, J. (2001) Gene expression profiling in Hodgkin's disease-derived cell lines: Effect of NF-kappa B inhibition. Blood, 98, p. 4317.

MacKenzie, J., and Jarrett, R. (2001) A study of global gene expression in Hodgkin's disease derived cell lines using gene microarrays. Leukemia and Lymphoma, 42, p. 12.

Book Sections

Jarrett, R. F., Gallagher, A., and Gatherer, D. (2013) Molecular methods of virus detection in lymphoma. In: Küppers, R. (ed.) Lymphoma: Methods and Protocols. Series: Methods in Molecular Biology (971). Humana Press, pp. 277-293. ISBN 9781627032681 (doi:10.1007/978-1-62703-269-8_16)

This list was generated on Fri Jun 24 14:04:12 2016 BST.

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