Institute of Infection, Immunity and Inflammation

Dr Richard Burchmore

  • Senior Lecturer (Parasitology)

telephone: 01413308612
email: Richard.Burchmore@glasgow.ac.uk


The role of membrane transporters in parasite virulence and drug susceptibility.

Current Research :

My research is focused on understanding, at the molecular level, the mechanisms by which parasites thrive in the challenging environments which they encounter. Complex phenotypes such as drug resistance and virulence are of central relevance in parasitology and are amenable to global approaches such as proteomics and metabolomics. In recent years I have brought these new technologies to bear upon the systems biology of parasites and of host:parasite interactions. In parallel, I have applied more conventional reverse genetic and biochemical approaches to specifically perturb parasite systems and to validate the results of proteomic analyses.
My primary parasite of interest is Leishmania, but I have also worked extensively with trypanosomes. Through collaborative links with other parasitologists, I have applied proteomic approaches to a diverse range of parasites, as well as to other biological systems. Current areas of research focus include understanding the role of nutrient transporters and stress responses in parasite development, virulence and drug resistance.

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Jump to: 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
Number of items: 74.

2013

Morrice, N., and Burchmore, R. (2013) Editorial. Journal of Proteomics, 88 . pp. 1-3. ISSN 1874-3919 (doi:10.1016/j.jprot.2013.05.035)

Roncada, P., Stipetic, L.H., Bonizzi, L., Burchmore, R.J.S., and Kennedy, M.W. (2013) Proteomics as a tool to explore human milk in health and disease. Journal of Proteomics, 88 . pp. 47-57. ISSN 1874-3919 (doi:10.1016/j.jprot.2013.04.008)

Atherton, M.J., Braceland, M., Fontaine, S., Waterston, M.M., Burchmore, R.J., Eadie, S., Eckersall, P.D., and Morris, J.S. (2013) Changes in the serum proteome of canine lymphoma identified by electrophoresis and mass spectrometry. Veterinary Journal, 196 (3). pp. 320-324. ISSN 1090-0233 (doi:10.1016/j.tvjl.2012.12.010)

Atherton, M.J., Braceland, M., Harvie, J., Burchmore, R.J., Eadie, S., Eckersall, P.D., and Morris, J.S. (2013) Characterisation of the normal canine serum proteome using a novel electrophoretic technique combined with mass spectrometry. Veterinary Journal, 196 (3). pp. 315-319. ISSN 1090-0233 (doi:10.1016/j.tvjl.2012.12.011)

Feng, X., Rodriguez-Contreras, D., Polley, T., Lye, L.-F., Scott, D., Burchmore, R.J.S., Beverley, S.M., and Landfear, S.M. (2013) 'Transient' genetic suppression facilitates generation of hexose transporter null mutants inLeishmania mexicana. Molecular Microbiology, 87 (2). pp. 412-429. ISSN 0950-382X (doi:10.1111/mmi.12106)

Bain, M.M., McDade, K., Burchmore, R., Law, A., Wilson, P.W., Schmutz, M., Preisinger, R., and Dunn, I.C. (2013) Enhancing the egg's natural defence against bacterial penetration by increasing cuticle deposition. Animal Genetics . ISSN 0268-9146 (doi:10.1111/age.12071) (In Press)

Monnerat, S., Almeida Costa, C.I., Forkert, A.C., Benz, C., Hamilton, A., Tetley, L., Burchmore, R., Novo, C., Mottram, J.C., and Hammarton, T.C. (2013) Identification and functional characterisation of CRK12:CYC9, a novel cyclin-dependent kinase (CDK)-cyclin complex in Trypanosoma brucei. PLoS ONE, 8 (6). e67327. ISSN 1932-6203 (doi:10.1371/journal.pone.0067327)

Shafie, I.N.F., McLaughlin, M., Burchmore, R., Lim, M.A.A., Montague, P., Johnston, P.E.J., Penderis, J., and Anderson, T. (2013) The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog. Cell Stress and Chaperones . ISSN 1355-8145 (doi:10.1007/s12192-013-0457-4) (In Press)

2012

Burchmore, R. (2012) Parasites in the brain? The search for sleeping sickness biomarkers. Expert Review of Anti-Infective Therapy, 10 (11). pp. 1283-1286. ISSN 1478-7210 (doi:10.1586/ERI.12.124)

Daneshvar, H., Sedghy, F., Dabiri, S., Kamiabi, H., Molaei, M.M., Phillips, S., and Burchmore, R. (2012) Alteration in mononuclear cell subpopulations in dogs immunized with gentamicin-attenuated Leishmania infantum. Parasitology, 139 (13). pp. 1689-1696. ISSN 0031-1820 (doi:10.1017/S0031182012001187)

Burgess, K.E.V., and Burchmore, R.J.S. (2012) Strategies to dissect parasite proteomes. Parasitology, 139 (9). pp. 1119-1130. ISSN 0031-1820 (doi:10.1017/S0031182011002368)

Ginger, M.L., McKean, P.G., Burchmore, R.J.S., and Grant, K.M. (2012) Proteomic insights into parasite biology. Parasitology, 139 (9). pp. 1101-1102. ISSN 0031-1820 (doi:10.1017/S0031182012000947)

McNamara, L.E., Burchmore, R.J.S., Riehle, M.O., Herzyk, P., Biggs, M.J.P., Wilkinson, C.D.W., Curtis, A.S.G., and Dalby, M.J. (2012) The role of microtopography in cellular mechanotransduction. Biomaterials, 33 (10). pp. 2835-2847. ISSN 0142-9612 (doi:10.1016/j.biomaterials.2011.11.047)

Daneshvar, H., Wyllie, S., Phillips, S., Hagan, P., and Burchmore, R. (2012) Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism. Journal of Proteomics, 75 (5). pp. 1463-1471. ISSN 1874-3919 (doi:10.1016/j.jprot.2011.11.018)

E-komon, T., Burchmore, R., Herzyk, P., and Davies, R. (2012) Predicting the outer membrane proteome of Pasteurella multocida based on consensus prediction enhanced by results integration and manual confirmation. BMC Bioinformatics, 13 (1). p. 63. ISSN 1471-2105 (doi:10.1186/1471-2105-13-63)

Kuboki, T., Kantawong, F., Burchmore, R., Dalby, M.J., and Kidoaki, S. (2012) 2D-DIGE proteomic analysis of mesenchymal stem cell cultured on the elasticity-tunable hydrogels. Cell Structure and Function, 37 (2). pp. 127-139. ISSN 0386-7196 (doi:10.1247/csf.12012)

McNamara, L.E., Kantawong, F., Dalby, M.J., Riehle, M.O., and Burchmore, R.J.S. (2012) Preventing and troubleshooting artefacts in saturation labelled fluorescence 2D difference gel electrophoresis (saturation DiGE). Proteomics, 11 (24). pp. 4610-4621. ISSN 1615-9853 (doi:10.1002/pmic.201100135)

Tiengwe, C., Marcello, L., Farr, H., Gadelha, C., Burchmore, R., Barry, J.D., Bell, S.D., and McCulloch, R. (2012) Identification of ORC1/CDC6-interacting factors in trypanosoma brucei reveals critical features of origin recognition complex architecture. PLoS ONE, 7 (3). e32674. ISSN 1932-6203 (doi:10.1371/journal.pone.0032674)

Vincent, I.M., Creek, D.J., Burgess, K., Woods, D.J., Burchmore, R.J.S., and Barrett, M.P. (2012) Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei. PLoS Neglected Tropical Diseases, 6 (5). e1618. ISSN 1935-2727 (doi:10.1371/journal.pntd.0001618)

2011

Hounsome, J.D.A., Baillie, S., Noofeli, M., Riboldi-Tunnicliffe, A., Burchmore, R.J.S., Isaacs, N.W., and Davies, R.L. (2011) Outer membrane protein A of bovine and ovine isolates of mannheimia haemolytica is surface exposed and contains host species-specific epitopes. Infection and Immunity, 79 (11). pp. 4332-4341. ISSN 0019-9567 (doi:10.1128/IAI.05469-11 )

Higon, M. et al. (2011) Screening trematodes for novel intervention targets: a proteomic and immunological comparison of Schistosoma haematobium, Schistosoma bovis and Echinostoma caproni. Parasitology, 138 (12). pp. 1607-1619. ISSN 0031-1820 (doi:10.1017/S0031182011000412)

Barrett, M.P., Vincent, I.M., Burchmore, R.J.S., Kazibwe, A.J.N., and Matovu, E. (2011) Drug resistance in human African trypanosomiasis. Future Microbiology, 6 (9). pp. 1037-1047. ISSN 1746-0913 (doi:10.2217/fmb.11.88)

Gerou-Ferriani, M., McBrearty, A.R., Burchmore, R.J., Jayawardena, K.G.I., Eckersall, P.D., and Morris, J.S. (2011) Agarose gel serum protein electrophoresis in cats with and without lymphoma and preliminary results of tandem mass fingerprinting analysis. Veterinary Clinical Pathology, 40 (2). pp. 159-173. ISSN 0275-6382 (doi:10.1111/j.1939-165X.2011.00310.x)

Wang, D. et al. (2011) Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds. Journal of Biological Chemistry, 286 (34). pp. 29922-29931. ISSN 0021-9258 (doi:10.1074/jbc.M111.233858)

Ward, C.P., Wong, P.E., Burchmore, R.J.S., De Koning, H.P., and Barrett, M.P. (2011) Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns. Antimicrobial Agents and Chemotherapy, 55 (5). pp. 2352-2361. ISSN 0066-4804 (doi:10.1128/AAC.01551-10)

2010

Naula, C.M., Logan, F.M., Wong, P.E., Barrett, M.P., and Burchmore, R.J. (2010) A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter. Journal of Biological Chemistry, 285 (39). pp. 29721-29728. ISSN 0021-9258 (doi:10.1074/jbc.M110.106815)

Kantawong, F., Burgess, K.E.V., Jayawardena, K., Hart, A., Riehle, M.O., Oreffo, R.O., Dalby, M.J., and Burchmore, R. (2010) Effects of a surface topography composite with puerariae radix on human STRO-1-positive stem cells. Acta Biomaterialia, 6 (9). pp. 3694-3703. ISSN 1742-7061 (doi:10.1016/j.actbio.2010.02.038)

Murphy, L., Eckersall, P.D., Bishop, S.C., Pettit, J.J., Huntley, J.F., Burchmore, R.J.S., and Stear, M.J. (2010) Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta. Parasitology, 137 (8). pp. 1249-1260. ISSN 0031-1820 (doi:10.1017/S0031182010000028)

Szoor, B., Ruberto, I., Burchmore, R.J.S., and Matthews, K.R. (2010) A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway. Genes and Development, 24 (12). pp. 1306-1316. ISSN 0890-9369 (doi:10.1101/gad.570310)

Burchmore, R.J.S. (2010) Neuroproteomics. Expert Review of Proteomics, 7 (3). pp. 331-332. ISSN 1478-9450 (doi:10.1586/epr.10.17)

McNamara, L.E., Dalby, M.J., Riehle, M.O., and Burchmore, R.J.S. (2010) Fluorescence two-dimensional difference gel electrophoresis for biomaterial applications. Journal of the Royal Society: Interface, 7 (Sppl 1). S107-S118. ISSN 1742-5689 (doi:10.1098/rsif.2009.0177.focus)

Stewart, M.L. et al. (2010) Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes. Eukaryotic Cell, 9 (2). pp. 336-343. ISSN 1535-9778

Vincent, I., Scotcher, J., and Burchmore, R. (2010) Sixth exploratory measurement science group symposium. Expert Review of Proteomics, 7 (1). pp. 19-20. ISSN 1478-9450 (doi:10.1586/epr.09.88)

Luu, V., Brems, S., Hoheisel, J.D., Burchmore, R., Guilbride, D.L., and Clayton, C. (2010) Corrigendum to "Functional analysis of Trypanosoma brucei PUF1" [Mol. Biochem. Parasitol. 150 (2006) 340–349]. Molecular and Biochemical Parasitology, 169 (1). p. 70. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2009.09.003)

Romero, I.C., Mehaffy, C., Burchmore, R.J.S., Dobos-Elder, K., Brennan, P., and Walker, J. (2010) Identification of promoter-binding proteins of the fbp A and C genes in Mycobacterium tuberculosis. Tuberculosis, 90 (1). pp. 25-30. ISSN 1472-9792 (doi:10.1016/j.tube.2009.10.001)

Daneshevar, H., Molaei, M. M., Kamiabi, H., Burchmore, R.J.S., Hagan, P., and Phillips, R.S. (2010) Gentamicin-attenuated Leishmania infantum: cellular immunity production and protection of dogs against experimental canine leishmaniasis. Parasite Immunology, 32 (11-12). pp. 722-730. ISSN 0141-9838 (doi:10.1111/j.1365-3024.2010.01237.x)

Kantawong, Fahsai, Burgess, Karl E.V., Jayawardena, Kamburapola, Hart, Andrew, Riehle, M.O., Oreffo, Richard O., Dalby, M.J., and Burchmore, R.J.S. (2010) Effects of a surface topography composite with puerariae radix on human STRO-1-positive stem cells. Acta Biomaterialia, 6 (9). pp. 3694-3703. ISSN 1742-7061 (doi:10.1016/j.actbio.2010.02.038)

Mutapi, F., Bourke, C., Harcus, Y., Midzi, N., Mduluza, T., Turner, C.M.R., Burchmore, R.J.S., and Maizels, R.M. (2010) Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4. Parasite Immunology, 33 (3). pp. 181-192. ISSN 0141-9838 (doi:10.1111/j.1365-3024.2010.01270.x)

Vincent, I.M., Creek, D., Watson, D.G., Kamleh, M.A., Woods, D.J., Wong, P.E., Burchmore, R.J.S., and Barrett, M.P. (2010) A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathogens, 6 (11). e1001204. ISSN 1553-7366 (doi:10.1371/journal.ppat.1001204)

Ward, Christopher P., Burgess, Karl E.V., Burchmore, R.J.S., Barrett, M.P., and De Koning, H.P. (2010) A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes. Molecular and Biochemical Parasitology, 174 (2). pp. 145-149. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2010.07.002)

2009

Kantawong, F., Burchmore, R.J.S., Gadegaard, N., Oreffo, R.O.C., and Dalby, M.J. (2009) Proteomic analysis of human osteoprogenitor response to disordered nanotopography. Journal of the Royal Society: Interface . ISSN 1742-5689 (doi:10.1098/rsif.2008.0447)

Kantawong, F., Burgess, K.E.V., Jayawardena, K., Hart, A., Burchmore, R.J., Gadegaard, N., Oreffo, R.O.C., and Dalby, M.J. (2009) Whole proteome analysis of osteoprogenitor differentiation induced by disordered nanotopography and mediated by ERK signalling. Biomaterials, 30 (27). pp. 4723-4731. ISSN 0142-9612 (doi:10.1016/j.biomaterials.2009.05.040)

Rossi, L., Riehle, M.O., McNamara, L.E., Burchmore, R.J., Dalby, M.J., McMurray, R.J., Gadegaard, N., Ahmed, S.R., and Tsimbouri, P. (2009) Research highlights. Nanomedicine, 4 (6). pp. 613-617. ISSN 1743-5889 (doi:10.2217/nnm.09.46)

Kantawong, F., Burchmore, R.J.S., Wilkinson, C.D.W., Oreffo, R.O.C., and Dalby, M.J. (2009) Differential in-gel electrophoresis (DIGE) analysis of human bone marrow osteoprogenitor cell contact guidance. Acta Biomaterialia, 5 (4). pp. 1137-1146. ISSN 1742-7061 (doi:10.1016/j.actbio.2008.11.001)

Ataei, S., Burchmore, R.J.S., Hodgson, J.C., Finucane, A., Parton, R.G., and Coote, J.G. (2009) Identification of immunogenic proteins associated with protection against haemorrhagic septicaemia after vaccination of calves with a live-attenuated aroA derivative of Pasteurella multocida B:2. Research in Veterinary Science, 87 (2). pp. 207-210. ISSN 0034-5288 (doi:10.1016/j.rvsc.2009.01.007)

Daneshvar, H., Burchmore, R.J.S., Hagan, P., and Phillips, R.S. (2009) Leishmania major H-line attenuated under pressure of gentamicin, induces a Th1 response which protects susceptible BALB/c mice against infection with virulent L. major. Parasitology, 136 (11). pp. 1243-1250. ISSN 0031-1820 (doi:10.1017/S0031182009990679)

Daneshvar, H., Molaei, M.M., Afshar, R.M., Kamiabi, H., Burchmore, R.J.S., Hagan, P., and Phillips, R.S. (2009) Gentamicin-attenuated Leishmania infantum: A clinicopathological study in dogs. Veterinary Immunology and Immunopathology, 129 (1-2). pp. 28-35. ISSN 0165-2427 (doi:10.1016/j.vetimm.2008.12.002)

Ross, L., Riehle, M.O., McNamara, L.E., Burchmore, R.J.S., Dalby, M.J., McMurray, R.J., Gadegaard, N., Ahmed, S., and Tsimbouri, P.M. (2009) Research highlights. Nanomedicine, 4 (6). pp. 613-617. ISSN 1743-5889 (doi:10.2217/nnm.09.46)

2008

Dalby, M.J., McNamara, L.E., Riehle, M.O., Burchmore, R.J.S., Kuntanawat, P., McMurray, R.J., Gadegaard, N., and Andar, A. (2008) Research highlights. Nanomedicine, 3 (4). pp. 411-414. ISSN 1743-5889 (doi:10.2217/17435889.3.4.411)

Kamleh, A., Barrett, M.P., Wildridge, D., Burchmore, R.J.S., Scheltema, R.A.., and Watson, D.G. (2008) Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules. Rapid Communications in Mass Spectrometry, 22 (12). pp. 1912-1918. ISSN 0951-4198 (doi:10.1002/rcm.3564)

Bridges, D.J., Pitt, A.R., Hanrahan, O., Brennan, K., Voorheis, H.P., Herzyk, P., De Koning, H.P., and Burchmore, R.J.S. (2008) Characterisation of the plasma membrane subproteome of bloodstream form Trypanosoma brucei. Proteomics, 8 (1). pp. 83-99. ISSN 1615-9853 (doi:10.1002/pmic.200700607)

Bridges, D.J., Pitt, A.R., Hanrahan, O., Brennan, K., Voorheis, H.P., Herzyk, P., de Koning, H.P., and Burchmore, R.J.S. (2008) Characterisation of the plasma membrane subproteome of bloodstream form Trypanosoma brucei. Proteomics, 8 (1). pp. 83-99. ISSN 1615-9853 (doi:10.1002/pmic.200700607)

Mutapi, F., Burchmore, R.J.S., Mduluza, T., Midzi, N., Turner, C.M.R., and Maizels, Rick M. (2008) Age‐related and infection intensity–related shifts in antibody recognition of defined protein antigens in a schistosome‐exposed population. Journal of Infectious Diseases, 198 (2). pp. 167-175. ISSN 0022-1899 (doi:10.1086/589511)

2007

Bridges, DJ, Gould, MK, Nerima, B, Maser, P, Burchmore, RJS, and de Koning, HP (2007) Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes. Molecular Pharmacology, 71 . pp. 1098-1108. (doi:10.1124/mol.106.031351)

Hannigan, A, Burchmore, R, and Wilson, JB (2007) The optimization of Protocols for Proteome difference gel electrophoresis (DiGE) analysis of Preneoplastic skin. Journal of Proteome Research, 6 . pp. 3422-3432. (doi:10.1021/pr0606878)

Naula, C., Alibu, V., Brock, J., Veitch, N.J., Burchmore, R.J.S., and Barrett, M. (2007) A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase. Journal of Biochemical and Biophysical Methods, 70 (6). pp. 1185-1187. (doi:10.1016/j.jprot.2007.11.002)

Nelson, M.M., Jones, A.R., Carmen, J.C., Sinai, A.P,, Burchmore, R., and Wastling, J.M. (2007) Modulation of the host cell proteome by the intracellular apicomplexan parasite Toxoplasma gondii. Infection and Immunity, 76 (2). pp. 828-844. (doi:10.1128/IAI.01115-07)

2006

Luu, V.D., Brems, S., Hoheisel, J.D., Burchmore, R., Guilbride, D.L., and Clayton, C. (2006) Functional analysis of Trypanosoma brucei PUF1. Molecular and Biochemical Parasitology, 150 (2). pp. 340-349. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2006.09.007)

Burchmore, R. (2006) Identification of anti-infective targets through comparative proteomics. Expert Review of Anti-Infective Therapy, 4 (2). pp. 163-165. (doi:10.1586/14787210.4.2.163)

Walker, J, Vasquez, JJ, Gomez, MA, Drummelsmith, J, Burchmore, R, Girard, I, and Ouellette, M (2006) Identification of developmentally-regulated proteins in Leishmania panamensis promastigotes and by proteome profiling of axenic amastigotes. Molecular and Biochemical Parasitology, 147 . pp. 64-73. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2006.01.008)

2005

Mutapi, F, Burchmore, R, Mduluza, T, Foucher, A, Harcus, Y, Nicoll, G, Midzi, N, Turner, CM, and Maizels, RM (2005) Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined parasite antigens. Journal of Infectious Diseases, 192 . pp. 1108-1118.

Stewart, ML, Krishna, S, Burchmore, RJS, Brun, R, de Koning, HP, Boykin, DW, Tidwell, RR, Hall, JE, and Barrett, MP (2005) Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet, 366 . pp. 486-487. ISSN 0140-6736 (doi:10.1016/S0140-6736(05)66793-1)

de Koning, HP, Bridges, DJ, and Burchmore, RJS (2005) Purine and pyrimidine transport in pathogenic protozoa: From biology to therapy. Fems Microbiology Reviews, 29 . pp. 987-1020. (doi:10.1016/j.femsre.2005.03.004)

2004

de Koning, HP, Anderson, LF, Stewart, M, Burchmore, RJS, Wallace, LJM, and Barrett, MP (2004) The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in African trypanosomes. Antimicrobial Agents and Chemotherapy, 48 . pp. 1515-1519. ISSN 0066-4804 (doi:10.1128/AAC.48.5.1515-1519.2004)

2003

Barrett, MP, Burchmore, RJS, Stich, A, Lazzari, JO, Frasch, AC, Cazzulo, JJ, and Krishna, S (2003) The trypanosomiases. Lancet, 362 . pp. 1469-1480.

Burchmore, R. (2003) A plethora of targets, a paucity of drugs: Progress towards the development of novel chemotherapies for human African trypanosomiasis. Expert Review of Anti-Infective Therapy, 1 (1). pp. 157-165. ISSN 1478-7210 (doi:10.1586/14787210.1.1.157)

Burchmore, RJS, Rodriguez-Contreras, D, McBride, K, Barrett, MP, Modi, G, Sacks, D, and Landfear, SM (2003) Genetic characterization of glucose transporter function in Leishmania mexicana. Proceedings of the National Academy of Sciences of the United States of America, 100 . pp. 3901-3906. (doi:10.1073/pnas.0630165100)

Burchmore, RJS, Wallace, LJM, Candlish, D, Al-Salabi, MI, Beal, PR, Barrett, MP, Baldwin, SA, and de Koning, HP (2003) Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan. Journal of Biological Chemistry, 278 . pp. 23502-23507. ISSN 0021-9258 (doi:10.1074/jbc.M301252200)

Matovu, E. et al. (2003) Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryotic Cell, 2 (5). pp. 1003-1008. ISSN 1535-9778 (doi:10.1128/EC.2.5.1003-1008.2003)

Maugeri, DA, Cazzulo, JJ, Burchmore, RJS, Barrett, MP, and Ogbunude, POJ (2003) Pentose phosphate metabolism in Leishmania mexicana. Molecular and Biochemical Parasitology, 130 . pp. 117-125. ISSN 0166-6851 (doi:10.1016/S0166-6851(03)00173-7)

2002

Leslie, G., Barrett, M., and Burchmore, R. (2002) Leishmania mexicana: promastigotes migrate through osmotic gradients. Experimental Parasitology, 102 (2). pp. 117-120. ISSN 0014-4894 (doi:10.1016/S0014-4894(03)00031-6)

Burchmore, RJS, Ogbunude, POJ, Enanga, B, and Barrett, MP (2002) Chemotherapy of human African trypanosomiasis. Current Pharmaceutical Design, 8 . pp. 257-267.

Enanga, B, Burchmore, RJS, Stewart, ML, and Barrett, MP (2002) Sleeping sickness and the brain. Cellular and Molecular Life Sciences, 59 . pp. 845-858.

2001

Burchmore, RJS, and Barrett, MP (2001) Life in vacuoles - nutrient acquisition by Leishmania amastigotes. International Journal For Parasitology, 31 . pp. 1311-1320.

This list was generated on Wed Oct 2 06:49:31 2013 BST.
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Number of items: 74.

Article

Morrice, N., and Burchmore, R. (2013) Editorial. Journal of Proteomics, 88 . pp. 1-3. ISSN 1874-3919 (doi:10.1016/j.jprot.2013.05.035)

Roncada, P., Stipetic, L.H., Bonizzi, L., Burchmore, R.J.S., and Kennedy, M.W. (2013) Proteomics as a tool to explore human milk in health and disease. Journal of Proteomics, 88 . pp. 47-57. ISSN 1874-3919 (doi:10.1016/j.jprot.2013.04.008)

Atherton, M.J., Braceland, M., Fontaine, S., Waterston, M.M., Burchmore, R.J., Eadie, S., Eckersall, P.D., and Morris, J.S. (2013) Changes in the serum proteome of canine lymphoma identified by electrophoresis and mass spectrometry. Veterinary Journal, 196 (3). pp. 320-324. ISSN 1090-0233 (doi:10.1016/j.tvjl.2012.12.010)

Atherton, M.J., Braceland, M., Harvie, J., Burchmore, R.J., Eadie, S., Eckersall, P.D., and Morris, J.S. (2013) Characterisation of the normal canine serum proteome using a novel electrophoretic technique combined with mass spectrometry. Veterinary Journal, 196 (3). pp. 315-319. ISSN 1090-0233 (doi:10.1016/j.tvjl.2012.12.011)

Feng, X., Rodriguez-Contreras, D., Polley, T., Lye, L.-F., Scott, D., Burchmore, R.J.S., Beverley, S.M., and Landfear, S.M. (2013) 'Transient' genetic suppression facilitates generation of hexose transporter null mutants inLeishmania mexicana. Molecular Microbiology, 87 (2). pp. 412-429. ISSN 0950-382X (doi:10.1111/mmi.12106)

Bain, M.M., McDade, K., Burchmore, R., Law, A., Wilson, P.W., Schmutz, M., Preisinger, R., and Dunn, I.C. (2013) Enhancing the egg's natural defence against bacterial penetration by increasing cuticle deposition. Animal Genetics . ISSN 0268-9146 (doi:10.1111/age.12071) (In Press)

Monnerat, S., Almeida Costa, C.I., Forkert, A.C., Benz, C., Hamilton, A., Tetley, L., Burchmore, R., Novo, C., Mottram, J.C., and Hammarton, T.C. (2013) Identification and functional characterisation of CRK12:CYC9, a novel cyclin-dependent kinase (CDK)-cyclin complex in Trypanosoma brucei. PLoS ONE, 8 (6). e67327. ISSN 1932-6203 (doi:10.1371/journal.pone.0067327)

Shafie, I.N.F., McLaughlin, M., Burchmore, R., Lim, M.A.A., Montague, P., Johnston, P.E.J., Penderis, J., and Anderson, T. (2013) The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog. Cell Stress and Chaperones . ISSN 1355-8145 (doi:10.1007/s12192-013-0457-4) (In Press)

Burchmore, R. (2012) Parasites in the brain? The search for sleeping sickness biomarkers. Expert Review of Anti-Infective Therapy, 10 (11). pp. 1283-1286. ISSN 1478-7210 (doi:10.1586/ERI.12.124)

Daneshvar, H., Sedghy, F., Dabiri, S., Kamiabi, H., Molaei, M.M., Phillips, S., and Burchmore, R. (2012) Alteration in mononuclear cell subpopulations in dogs immunized with gentamicin-attenuated Leishmania infantum. Parasitology, 139 (13). pp. 1689-1696. ISSN 0031-1820 (doi:10.1017/S0031182012001187)

Burgess, K.E.V., and Burchmore, R.J.S. (2012) Strategies to dissect parasite proteomes. Parasitology, 139 (9). pp. 1119-1130. ISSN 0031-1820 (doi:10.1017/S0031182011002368)

Ginger, M.L., McKean, P.G., Burchmore, R.J.S., and Grant, K.M. (2012) Proteomic insights into parasite biology. Parasitology, 139 (9). pp. 1101-1102. ISSN 0031-1820 (doi:10.1017/S0031182012000947)

McNamara, L.E., Burchmore, R.J.S., Riehle, M.O., Herzyk, P., Biggs, M.J.P., Wilkinson, C.D.W., Curtis, A.S.G., and Dalby, M.J. (2012) The role of microtopography in cellular mechanotransduction. Biomaterials, 33 (10). pp. 2835-2847. ISSN 0142-9612 (doi:10.1016/j.biomaterials.2011.11.047)

Daneshvar, H., Wyllie, S., Phillips, S., Hagan, P., and Burchmore, R. (2012) Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism. Journal of Proteomics, 75 (5). pp. 1463-1471. ISSN 1874-3919 (doi:10.1016/j.jprot.2011.11.018)

E-komon, T., Burchmore, R., Herzyk, P., and Davies, R. (2012) Predicting the outer membrane proteome of Pasteurella multocida based on consensus prediction enhanced by results integration and manual confirmation. BMC Bioinformatics, 13 (1). p. 63. ISSN 1471-2105 (doi:10.1186/1471-2105-13-63)

Kuboki, T., Kantawong, F., Burchmore, R., Dalby, M.J., and Kidoaki, S. (2012) 2D-DIGE proteomic analysis of mesenchymal stem cell cultured on the elasticity-tunable hydrogels. Cell Structure and Function, 37 (2). pp. 127-139. ISSN 0386-7196 (doi:10.1247/csf.12012)

McNamara, L.E., Kantawong, F., Dalby, M.J., Riehle, M.O., and Burchmore, R.J.S. (2012) Preventing and troubleshooting artefacts in saturation labelled fluorescence 2D difference gel electrophoresis (saturation DiGE). Proteomics, 11 (24). pp. 4610-4621. ISSN 1615-9853 (doi:10.1002/pmic.201100135)

Tiengwe, C., Marcello, L., Farr, H., Gadelha, C., Burchmore, R., Barry, J.D., Bell, S.D., and McCulloch, R. (2012) Identification of ORC1/CDC6-interacting factors in trypanosoma brucei reveals critical features of origin recognition complex architecture. PLoS ONE, 7 (3). e32674. ISSN 1932-6203 (doi:10.1371/journal.pone.0032674)

Vincent, I.M., Creek, D.J., Burgess, K., Woods, D.J., Burchmore, R.J.S., and Barrett, M.P. (2012) Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei. PLoS Neglected Tropical Diseases, 6 (5). e1618. ISSN 1935-2727 (doi:10.1371/journal.pntd.0001618)

Hounsome, J.D.A., Baillie, S., Noofeli, M., Riboldi-Tunnicliffe, A., Burchmore, R.J.S., Isaacs, N.W., and Davies, R.L. (2011) Outer membrane protein A of bovine and ovine isolates of mannheimia haemolytica is surface exposed and contains host species-specific epitopes. Infection and Immunity, 79 (11). pp. 4332-4341. ISSN 0019-9567 (doi:10.1128/IAI.05469-11 )

Higon, M. et al. (2011) Screening trematodes for novel intervention targets: a proteomic and immunological comparison of Schistosoma haematobium, Schistosoma bovis and Echinostoma caproni. Parasitology, 138 (12). pp. 1607-1619. ISSN 0031-1820 (doi:10.1017/S0031182011000412)

Barrett, M.P., Vincent, I.M., Burchmore, R.J.S., Kazibwe, A.J.N., and Matovu, E. (2011) Drug resistance in human African trypanosomiasis. Future Microbiology, 6 (9). pp. 1037-1047. ISSN 1746-0913 (doi:10.2217/fmb.11.88)

Gerou-Ferriani, M., McBrearty, A.R., Burchmore, R.J., Jayawardena, K.G.I., Eckersall, P.D., and Morris, J.S. (2011) Agarose gel serum protein electrophoresis in cats with and without lymphoma and preliminary results of tandem mass fingerprinting analysis. Veterinary Clinical Pathology, 40 (2). pp. 159-173. ISSN 0275-6382 (doi:10.1111/j.1939-165X.2011.00310.x)

Wang, D. et al. (2011) Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds. Journal of Biological Chemistry, 286 (34). pp. 29922-29931. ISSN 0021-9258 (doi:10.1074/jbc.M111.233858)

Ward, C.P., Wong, P.E., Burchmore, R.J.S., De Koning, H.P., and Barrett, M.P. (2011) Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns. Antimicrobial Agents and Chemotherapy, 55 (5). pp. 2352-2361. ISSN 0066-4804 (doi:10.1128/AAC.01551-10)

Naula, C.M., Logan, F.M., Wong, P.E., Barrett, M.P., and Burchmore, R.J. (2010) A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter. Journal of Biological Chemistry, 285 (39). pp. 29721-29728. ISSN 0021-9258 (doi:10.1074/jbc.M110.106815)

Kantawong, F., Burgess, K.E.V., Jayawardena, K., Hart, A., Riehle, M.O., Oreffo, R.O., Dalby, M.J., and Burchmore, R. (2010) Effects of a surface topography composite with puerariae radix on human STRO-1-positive stem cells. Acta Biomaterialia, 6 (9). pp. 3694-3703. ISSN 1742-7061 (doi:10.1016/j.actbio.2010.02.038)

Murphy, L., Eckersall, P.D., Bishop, S.C., Pettit, J.J., Huntley, J.F., Burchmore, R.J.S., and Stear, M.J. (2010) Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta. Parasitology, 137 (8). pp. 1249-1260. ISSN 0031-1820 (doi:10.1017/S0031182010000028)

Szoor, B., Ruberto, I., Burchmore, R.J.S., and Matthews, K.R. (2010) A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway. Genes and Development, 24 (12). pp. 1306-1316. ISSN 0890-9369 (doi:10.1101/gad.570310)

Burchmore, R.J.S. (2010) Neuroproteomics. Expert Review of Proteomics, 7 (3). pp. 331-332. ISSN 1478-9450 (doi:10.1586/epr.10.17)

McNamara, L.E., Dalby, M.J., Riehle, M.O., and Burchmore, R.J.S. (2010) Fluorescence two-dimensional difference gel electrophoresis for biomaterial applications. Journal of the Royal Society: Interface, 7 (Sppl 1). S107-S118. ISSN 1742-5689 (doi:10.1098/rsif.2009.0177.focus)

Stewart, M.L. et al. (2010) Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes. Eukaryotic Cell, 9 (2). pp. 336-343. ISSN 1535-9778

Vincent, I., Scotcher, J., and Burchmore, R. (2010) Sixth exploratory measurement science group symposium. Expert Review of Proteomics, 7 (1). pp. 19-20. ISSN 1478-9450 (doi:10.1586/epr.09.88)

Luu, V., Brems, S., Hoheisel, J.D., Burchmore, R., Guilbride, D.L., and Clayton, C. (2010) Corrigendum to "Functional analysis of Trypanosoma brucei PUF1" [Mol. Biochem. Parasitol. 150 (2006) 340–349]. Molecular and Biochemical Parasitology, 169 (1). p. 70. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2009.09.003)

Romero, I.C., Mehaffy, C., Burchmore, R.J.S., Dobos-Elder, K., Brennan, P., and Walker, J. (2010) Identification of promoter-binding proteins of the fbp A and C genes in Mycobacterium tuberculosis. Tuberculosis, 90 (1). pp. 25-30. ISSN 1472-9792 (doi:10.1016/j.tube.2009.10.001)

Daneshevar, H., Molaei, M. M., Kamiabi, H., Burchmore, R.J.S., Hagan, P., and Phillips, R.S. (2010) Gentamicin-attenuated Leishmania infantum: cellular immunity production and protection of dogs against experimental canine leishmaniasis. Parasite Immunology, 32 (11-12). pp. 722-730. ISSN 0141-9838 (doi:10.1111/j.1365-3024.2010.01237.x)

Kantawong, Fahsai, Burgess, Karl E.V., Jayawardena, Kamburapola, Hart, Andrew, Riehle, M.O., Oreffo, Richard O., Dalby, M.J., and Burchmore, R.J.S. (2010) Effects of a surface topography composite with puerariae radix on human STRO-1-positive stem cells. Acta Biomaterialia, 6 (9). pp. 3694-3703. ISSN 1742-7061 (doi:10.1016/j.actbio.2010.02.038)

Mutapi, F., Bourke, C., Harcus, Y., Midzi, N., Mduluza, T., Turner, C.M.R., Burchmore, R.J.S., and Maizels, R.M. (2010) Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4. Parasite Immunology, 33 (3). pp. 181-192. ISSN 0141-9838 (doi:10.1111/j.1365-3024.2010.01270.x)

Vincent, I.M., Creek, D., Watson, D.G., Kamleh, M.A., Woods, D.J., Wong, P.E., Burchmore, R.J.S., and Barrett, M.P. (2010) A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathogens, 6 (11). e1001204. ISSN 1553-7366 (doi:10.1371/journal.ppat.1001204)

Ward, Christopher P., Burgess, Karl E.V., Burchmore, R.J.S., Barrett, M.P., and De Koning, H.P. (2010) A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes. Molecular and Biochemical Parasitology, 174 (2). pp. 145-149. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2010.07.002)

Kantawong, F., Burchmore, R.J.S., Gadegaard, N., Oreffo, R.O.C., and Dalby, M.J. (2009) Proteomic analysis of human osteoprogenitor response to disordered nanotopography. Journal of the Royal Society: Interface . ISSN 1742-5689 (doi:10.1098/rsif.2008.0447)

Kantawong, F., Burgess, K.E.V., Jayawardena, K., Hart, A., Burchmore, R.J., Gadegaard, N., Oreffo, R.O.C., and Dalby, M.J. (2009) Whole proteome analysis of osteoprogenitor differentiation induced by disordered nanotopography and mediated by ERK signalling. Biomaterials, 30 (27). pp. 4723-4731. ISSN 0142-9612 (doi:10.1016/j.biomaterials.2009.05.040)

Rossi, L., Riehle, M.O., McNamara, L.E., Burchmore, R.J., Dalby, M.J., McMurray, R.J., Gadegaard, N., Ahmed, S.R., and Tsimbouri, P. (2009) Research highlights. Nanomedicine, 4 (6). pp. 613-617. ISSN 1743-5889 (doi:10.2217/nnm.09.46)

Kantawong, F., Burchmore, R.J.S., Wilkinson, C.D.W., Oreffo, R.O.C., and Dalby, M.J. (2009) Differential in-gel electrophoresis (DIGE) analysis of human bone marrow osteoprogenitor cell contact guidance. Acta Biomaterialia, 5 (4). pp. 1137-1146. ISSN 1742-7061 (doi:10.1016/j.actbio.2008.11.001)

Ataei, S., Burchmore, R.J.S., Hodgson, J.C., Finucane, A., Parton, R.G., and Coote, J.G. (2009) Identification of immunogenic proteins associated with protection against haemorrhagic septicaemia after vaccination of calves with a live-attenuated aroA derivative of Pasteurella multocida B:2. Research in Veterinary Science, 87 (2). pp. 207-210. ISSN 0034-5288 (doi:10.1016/j.rvsc.2009.01.007)

Daneshvar, H., Burchmore, R.J.S., Hagan, P., and Phillips, R.S. (2009) Leishmania major H-line attenuated under pressure of gentamicin, induces a Th1 response which protects susceptible BALB/c mice against infection with virulent L. major. Parasitology, 136 (11). pp. 1243-1250. ISSN 0031-1820 (doi:10.1017/S0031182009990679)

Daneshvar, H., Molaei, M.M., Afshar, R.M., Kamiabi, H., Burchmore, R.J.S., Hagan, P., and Phillips, R.S. (2009) Gentamicin-attenuated Leishmania infantum: A clinicopathological study in dogs. Veterinary Immunology and Immunopathology, 129 (1-2). pp. 28-35. ISSN 0165-2427 (doi:10.1016/j.vetimm.2008.12.002)

Ross, L., Riehle, M.O., McNamara, L.E., Burchmore, R.J.S., Dalby, M.J., McMurray, R.J., Gadegaard, N., Ahmed, S., and Tsimbouri, P.M. (2009) Research highlights. Nanomedicine, 4 (6). pp. 613-617. ISSN 1743-5889 (doi:10.2217/nnm.09.46)

Dalby, M.J., McNamara, L.E., Riehle, M.O., Burchmore, R.J.S., Kuntanawat, P., McMurray, R.J., Gadegaard, N., and Andar, A. (2008) Research highlights. Nanomedicine, 3 (4). pp. 411-414. ISSN 1743-5889 (doi:10.2217/17435889.3.4.411)

Kamleh, A., Barrett, M.P., Wildridge, D., Burchmore, R.J.S., Scheltema, R.A.., and Watson, D.G. (2008) Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules. Rapid Communications in Mass Spectrometry, 22 (12). pp. 1912-1918. ISSN 0951-4198 (doi:10.1002/rcm.3564)

Bridges, D.J., Pitt, A.R., Hanrahan, O., Brennan, K., Voorheis, H.P., Herzyk, P., De Koning, H.P., and Burchmore, R.J.S. (2008) Characterisation of the plasma membrane subproteome of bloodstream form Trypanosoma brucei. Proteomics, 8 (1). pp. 83-99. ISSN 1615-9853 (doi:10.1002/pmic.200700607)

Bridges, D.J., Pitt, A.R., Hanrahan, O., Brennan, K., Voorheis, H.P., Herzyk, P., de Koning, H.P., and Burchmore, R.J.S. (2008) Characterisation of the plasma membrane subproteome of bloodstream form Trypanosoma brucei. Proteomics, 8 (1). pp. 83-99. ISSN 1615-9853 (doi:10.1002/pmic.200700607)

Mutapi, F., Burchmore, R.J.S., Mduluza, T., Midzi, N., Turner, C.M.R., and Maizels, Rick M. (2008) Age‐related and infection intensity–related shifts in antibody recognition of defined protein antigens in a schistosome‐exposed population. Journal of Infectious Diseases, 198 (2). pp. 167-175. ISSN 0022-1899 (doi:10.1086/589511)

Bridges, DJ, Gould, MK, Nerima, B, Maser, P, Burchmore, RJS, and de Koning, HP (2007) Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes. Molecular Pharmacology, 71 . pp. 1098-1108. (doi:10.1124/mol.106.031351)

Hannigan, A, Burchmore, R, and Wilson, JB (2007) The optimization of Protocols for Proteome difference gel electrophoresis (DiGE) analysis of Preneoplastic skin. Journal of Proteome Research, 6 . pp. 3422-3432. (doi:10.1021/pr0606878)

Naula, C., Alibu, V., Brock, J., Veitch, N.J., Burchmore, R.J.S., and Barrett, M. (2007) A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase. Journal of Biochemical and Biophysical Methods, 70 (6). pp. 1185-1187. (doi:10.1016/j.jprot.2007.11.002)

Nelson, M.M., Jones, A.R., Carmen, J.C., Sinai, A.P,, Burchmore, R., and Wastling, J.M. (2007) Modulation of the host cell proteome by the intracellular apicomplexan parasite Toxoplasma gondii. Infection and Immunity, 76 (2). pp. 828-844. (doi:10.1128/IAI.01115-07)

Luu, V.D., Brems, S., Hoheisel, J.D., Burchmore, R., Guilbride, D.L., and Clayton, C. (2006) Functional analysis of Trypanosoma brucei PUF1. Molecular and Biochemical Parasitology, 150 (2). pp. 340-349. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2006.09.007)

Burchmore, R. (2006) Identification of anti-infective targets through comparative proteomics. Expert Review of Anti-Infective Therapy, 4 (2). pp. 163-165. (doi:10.1586/14787210.4.2.163)

Walker, J, Vasquez, JJ, Gomez, MA, Drummelsmith, J, Burchmore, R, Girard, I, and Ouellette, M (2006) Identification of developmentally-regulated proteins in Leishmania panamensis promastigotes and by proteome profiling of axenic amastigotes. Molecular and Biochemical Parasitology, 147 . pp. 64-73. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2006.01.008)

Mutapi, F, Burchmore, R, Mduluza, T, Foucher, A, Harcus, Y, Nicoll, G, Midzi, N, Turner, CM, and Maizels, RM (2005) Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined parasite antigens. Journal of Infectious Diseases, 192 . pp. 1108-1118.

Stewart, ML, Krishna, S, Burchmore, RJS, Brun, R, de Koning, HP, Boykin, DW, Tidwell, RR, Hall, JE, and Barrett, MP (2005) Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet, 366 . pp. 486-487. ISSN 0140-6736 (doi:10.1016/S0140-6736(05)66793-1)

de Koning, HP, Bridges, DJ, and Burchmore, RJS (2005) Purine and pyrimidine transport in pathogenic protozoa: From biology to therapy. Fems Microbiology Reviews, 29 . pp. 987-1020. (doi:10.1016/j.femsre.2005.03.004)

de Koning, HP, Anderson, LF, Stewart, M, Burchmore, RJS, Wallace, LJM, and Barrett, MP (2004) The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in African trypanosomes. Antimicrobial Agents and Chemotherapy, 48 . pp. 1515-1519. ISSN 0066-4804 (doi:10.1128/AAC.48.5.1515-1519.2004)

Barrett, MP, Burchmore, RJS, Stich, A, Lazzari, JO, Frasch, AC, Cazzulo, JJ, and Krishna, S (2003) The trypanosomiases. Lancet, 362 . pp. 1469-1480.

Burchmore, R. (2003) A plethora of targets, a paucity of drugs: Progress towards the development of novel chemotherapies for human African trypanosomiasis. Expert Review of Anti-Infective Therapy, 1 (1). pp. 157-165. ISSN 1478-7210 (doi:10.1586/14787210.1.1.157)

Burchmore, RJS, Rodriguez-Contreras, D, McBride, K, Barrett, MP, Modi, G, Sacks, D, and Landfear, SM (2003) Genetic characterization of glucose transporter function in Leishmania mexicana. Proceedings of the National Academy of Sciences of the United States of America, 100 . pp. 3901-3906. (doi:10.1073/pnas.0630165100)

Burchmore, RJS, Wallace, LJM, Candlish, D, Al-Salabi, MI, Beal, PR, Barrett, MP, Baldwin, SA, and de Koning, HP (2003) Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan. Journal of Biological Chemistry, 278 . pp. 23502-23507. ISSN 0021-9258 (doi:10.1074/jbc.M301252200)

Matovu, E. et al. (2003) Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryotic Cell, 2 (5). pp. 1003-1008. ISSN 1535-9778 (doi:10.1128/EC.2.5.1003-1008.2003)

Maugeri, DA, Cazzulo, JJ, Burchmore, RJS, Barrett, MP, and Ogbunude, POJ (2003) Pentose phosphate metabolism in Leishmania mexicana. Molecular and Biochemical Parasitology, 130 . pp. 117-125. ISSN 0166-6851 (doi:10.1016/S0166-6851(03)00173-7)

Leslie, G., Barrett, M., and Burchmore, R. (2002) Leishmania mexicana: promastigotes migrate through osmotic gradients. Experimental Parasitology, 102 (2). pp. 117-120. ISSN 0014-4894 (doi:10.1016/S0014-4894(03)00031-6)

Burchmore, RJS, Ogbunude, POJ, Enanga, B, and Barrett, MP (2002) Chemotherapy of human African trypanosomiasis. Current Pharmaceutical Design, 8 . pp. 257-267.

Enanga, B, Burchmore, RJS, Stewart, ML, and Barrett, MP (2002) Sleeping sickness and the brain. Cellular and Molecular Life Sciences, 59 . pp. 845-858.

Burchmore, RJS, and Barrett, MP (2001) Life in vacuoles - nutrient acquisition by Leishmania amastigotes. International Journal For Parasitology, 31 . pp. 1311-1320.

This list was generated on Wed Oct 2 06:49:31 2013 BST.

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Proteolysis and life cycle progression in Leishmania
    Medical Research Council
    2013 - 2018
     
  • Dynamic surfaces to mimic mesenchymal stem cell niche functions
    Biotechnology and Biological Sciences Research Council
    2013 - 2016
     
  • Can marine calcifying organisms use proteomic responses to adpat to anthropogenic global change? (ISSF Catalyst Fund)
    Wellcome Trust
    2011 - 2014
     
  • The silicon trypanosome (SilicoTryp)
    BBSRC
    2010 - 2013
     
  • Identification of proteins targeted by salicylic aldehyde inhibitors in Escherichia coli O157
    Medical Research Scotland
    2008 - 2010
     
  • Drug resistance in African trypanosomes
    MRC
    2008 - 2011
     
  • Assessment of the probability of developing resistance to novel trypanocides under consideration for late stage HAT
    The University of North Carolina at Chapel Hill
    2006 - 2008
     
  • The molecular basis of functional divergence between structurally similar monosaccharide transporters in Leishmania
    Wellcome Trust
    2005 - 2009
     
  • A comparative proteomic analysis of drug resistance in Leishmania
    World Health Organisation
    2004 - 2005
     

Editorial Board

  • 2007 - ongoing: Expert Review of Proteomics - Editorial Board Member
  • 2003 - ongoing: Future Drugs
  • 2003 - ongoing: Expert Review of Anti-Infective Therapy - Editorial Board Member

Invited International Presentations

  • 2006: Brussels, Belgium - Invited Speaker, COST action B22
  • 2005: Oregon, USA - Invited Speaker, Oregon Health Sciences University
  • 2005: Goa, India - Invited Speaker, Indo-Swedish Parasitology Meeting
  • 2001: Colorado, USA - Invited Speaker, FASEB Glucose Transporter Biology Conference

Research Fellowship

  • 1997 - 1998: American Heart Association Postdoctoral Fellowship
  • 1994 - 1995: American Heart Association Postdoctoral Fellowship