Dr Richard Burchmore

  • Senior Lecturer (Parasitology)
  • Associate - Life Sciences (School of Life Sciences)
  • Affiliate (Polyomics Facility)

telephone: 01413308612
email: Richard.Burchmore@glasgow.ac.uk

Research interests

The role of membrane transporters in parasite virulence and drug susceptibility.

Current Research :

My research is focused on understanding, at the molecular level, the mechanisms by which parasites thrive in the challenging environments which they encounter. Complex phenotypes such as drug resistance and virulence are of central relevance in parasitology and are amenable to global approaches such as proteomics and metabolomics. In recent years I have brought these new technologies to bear upon the systems biology of parasites and of host:parasite interactions. In parallel, I have applied more conventional reverse genetic and biochemical approaches to specifically perturb parasite systems and to validate the results of proteomic analyses.
My primary parasite of interest is Leishmania, but I have also worked extensively with trypanosomes. Through collaborative links with other parasitologists, I have applied proteomic approaches to a diverse range of parasites, as well as to other biological systems. Current areas of research focus include understanding the role of nutrient transporters and stress responses in parasite development, virulence and drug resistance.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Discovery and analysis of key components of Calcineurin signalling in malaria infection and transmission
    Wellcome Trust
    2016 - 2017
     
  • Thiol Modification and Redox Signalling
    Medical Research Council
    2016 - 2017
     
  • Investigating NF-kB p50 phosphorylation and the regulation of transcription
    Medical Research Council
    2015 - 2018
     
  • Linking the power of -omic technologies to translational research on neglected tropical diseases
    British Council
    2015 - 2017
     
  • Synergistic microenvironments for non-union bone defects
    Medical Research Council
    2014 - 2016
     
  • Molecular interactions of Mannheimia haemolytica with the bovine and ovine respiratory tracts using three-dimensional tissue engineering approaches
    Biotechnology and Biological Sciences Research Council
    2014 - 2017
     
  • Proteolysis and life cycle progression in Leishmania
    Medical Research Council
    2013 - 2018
     
  • Dynamic surfaces to mimic mesenchymal stem cell niche functions
    Biotechnology and Biological Sciences Research Council
    2013 - 2016
     
  • Can marine calcifying organisms use proteomic responses to adpat to anthropogenic global change? (ISSF Catalyst Fund)
    Wellcome Trust
    2011 - 2014
     
  • The silicon trypanosome (SilicoTryp)
    BBSRC
    2010 - 2013
     
  • Identification of proteins targeted by salicylic aldehyde inhibitors in Escherichia coli O157
    Medical Research Scotland
    2008 - 2010
     
  • Drug resistance in African trypanosomes
    MRC
    2008 - 2011
     
  • Assessment of the probability of developing resistance to novel trypanocides under consideration for late stage HAT
    The University of North Carolina at Chapel Hill
    2006 - 2008
     
  • The molecular basis of functional divergence between structurally similar monosaccharide transporters in Leishmania
    Wellcome Trust
    2005 - 2009
     
  • A comparative proteomic analysis of drug resistance in Leishmania
    World Health Organisation
    2004 - 2005
     

Additional information

Editorial Board

  • 2007 - ongoing: Expert Review of Proteomics - Editorial Board Member
  • 2003 - ongoing: Future Drugs
  • 2003 - ongoing: Expert Review of Anti-Infective Therapy - Editorial Board Member

Invited International Presentations

  • 2006: Brussels, Belgium - Invited Speaker, COST action B22
  • 2005: Oregon, USA - Invited Speaker, Oregon Health Sciences University
  • 2005: Goa, India - Invited Speaker, Indo-Swedish Parasitology Meeting
  • 2001: Colorado, USA - Invited Speaker, FASEB Glucose Transporter Biology Conference

Research Fellowship

  • 1997 - 1998: American Heart Association Postdoctoral Fellowship
  • 1994 - 1995: American Heart Association Postdoctoral Fellowship

Publications

List by: Type | Date

Jump to: 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
Number of items: 102.

2017

Martinez-Subiela, S., Horvatic, A., Escribano, D., Pardo-Marin, L., Kocaturk, M., Mrljak, V., Burchmore, R., Ceron, J. J. and Yilmaz, Z. (2017) Identification of novel biomarkers for treatment monitoring in canine leishmaniosis by high-resolution quantitative proteomic analysis. Veterinary Immunology and Immunopathology, 191, pp. 60-67. (doi:10.1016/j.vetimm.2017.08.004) (PMID:28895868)

Mwenechanya, R. et al. (2017) Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana. PLoS Neglected Tropical Diseases, 11(6), e0005649. (doi:10.1371/journal.pntd.0005649) (PMID:28622334)

Rojas, F., Koszela, J., Búa, J., Llorente, B., Burchmore, R., Auer, M., Mottram, J. C. and Téllez-Iñón, M. T. (2017) The ubiquitin-conjugating enzyme CDC34 is essential for cytokinesis in contrast to putative subunits of a SCF complex in Trypanosoma brucei. PLoS Neglected Tropical Diseases, 11(6), e0005626. (doi:10.1371/journal.pntd.0005626) (PMID:28609481)

Hulme, H. E. et al. (2017) Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection. Scientific Reports, 7, 2786. (doi:10.1038/s41598-017-03100-5)

O'Reilly, E. L., Burchmore, R. J., Sparks, N. H. and Eckersall, P. D. (2017) The effect of microbial challenge on the intestinal proteome of broiler chickens. Proteome Science, 15, 10. (doi:10.1186/s12953-017-0118-0) (PMID:28572745) (PMCID:PMC5450085)

Marcos-López, M., Rodger, H. D., O'Connor, I., Braceland, M., Burchmore, R. J.S., Eckersall, P. and MacCarthy, E. (2017) A proteomic approach to assess the host response in gills of farmed Atlantic salmon Salmo salar L. affected by amoebic gill disease. Aquaculture, 470, pp. 1-10. (doi:10.1016/j.aquaculture.2016.12.009)

Lindeberg, H. , Burchmore, R. J.S. and Kennedy, M. W. (2017) Pulse of inflammatory proteins in the pregnant uterus of European polecats (Mustela putorius) leading to the time of implantation. Royal Society Open Science, 4(3), 161085. (doi:10.1098/rsos.161085) (PMID:28405395) (PMCID:PMC5383852)

Akpunarlieva, S., Weidt, S., Lamasudin, D., Naula, C., Henderson, D., Barrett, M. , Burgess, K. and Burchmore, R. (2017) Integration of proteomics and metabolomics to elucidate metabolic adaptation in Leishmania. Journal of Proteomics, 155, pp. 85-98. (doi:10.1016/j.jprot.2016.12.009) (PMID:28040509)

2016

Schrama, D., Richard, N., Silva, T. S., Figueiredo, F. A., Conceição, L. E.C., Burchmore, R., Eckersall, D. and Rodrigues, P. M.L. (2016) Enhanced dietary formulation to mitigate winter thermal stress in gilthead sea bream (Sparus aurata): a 2D-DIGE plasma proteome study. Fish Physiology and Biochemistry, (doi:10.1007/s10695-016-0315-2) (PMID:27882445) (Early Online Publication)

Lobo-Rojas, Á. E., González-Marcano, E. B., Valera-Vera, E. A., Acosta, H. R., Quiñones, W. A., Burchmore, R. J.S., Concepción, J. L. and Cáceres, A. J. (2016) Trypanosoma cruzi contains two galactokinases; molecular and biochemical characterization. Parasitology International, 65(5 Pt A), pp. 472-482. (doi:10.1016/j.parint.2016.06.008) (PMID:27312997)

Ormsby, M. J., Caws, T., Burchmore, R., Wallis, T., Verner-Jeffreys, D. W. and Davies, R. L. (2016) Yersinia ruckeri isolates recovered from diseased Atlantic Salmon (Salmo salar) in Scotland are more diverse than those from Rainbow Trout (Oncorhynchus mykiss) and represent distinct subpopulations. Applied and Environmental Microbiology, 82(19), pp. 5785-5794. (doi:10.1128/aem.01173-16) (PMID:27451448)

Mudaliar, M. et al. (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 2. Label-free relative quantitative proteomics. Molecular BioSystems, 12(9), pp. 2748-2761. (doi:10.1039/C6MB00290K) (PMID:27412694) (PMCID:PMC5048399)

Thomas, F., Mudaliar, M. , Tassi, R., Mcneilly, T., Burchmore, R., Burgess, K., Herzyk, P., Zadoks, R. and Eckersall, P. (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 3. Untargeted metabolomics. Molecular BioSystems, 12(9), pp. 2762-2769. (doi:10.1039/C6MB00289G) (PMID:27412568)

Thomas, F., Mullen, W. , Tassi, R., Ramírez-Torres, A., Mudaliar, M. , Mcneilly, T., Zadoks, R., Burchmore, R. and Eckersall, P. (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 1. High abundance proteins, acute phase proteins and peptidomics. Molecular BioSystems, 12(9), pp. 2735-2747. (doi:10.1039/C6MB00239K) (PMID:27412456) (PMCID:PMC5048397)

Grewal, J. S. et al. (2016) PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast. Journal of Biological Chemistry, 291, pp. 9492-9500. (doi:10.1074/jbc.M116.714972) (PMID:26940875) (PMCID:PMC4850289)

2015

Griffiths, K., Rong, H., Wang, H., Zhang, Z., Zhang, T., Watson, D. G., Burchmore, R., Loeffler, I.K. and Kennedy, M. (2015) Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca. Royal Society Open Science, 2, 150395. (doi:10.1098/rsos.150395)

Haggarty, J., Oppermann, M., Dalby, M. J., Burchmore, R. J., Cook, K., Weidt, S. and Burgess, K. E.V. (2015) Serially coupling hydrophobic interaction and reversed-phase chromatography with simultaneous gradients provides greater coverage of the metabolome. Metabolomics, 11(5), pp. 1465-1470. (doi:10.1007/s11306-014-0770-7) (PMID:26366140) (PMCID:PMC4559102)

Fyfe, C.D., Grinter, R., Josts, I., Mosbahi, K., Roszak, A.W., Cogdell, R.J., Wall, D.M., Burchmore, R.J.S., Byron, O. and Walker, D. (2015) Structure of protease-cleaved escherichia coliα-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment. Acta Crystallographica. Section D: Biological Crystallography, 71(7), pp. 1478-1486. (doi:10.1107/s1399004715008548) (PMID:26143919) (PMCID:PMC4498604)

Hajjaran, H., Mousavi, P., Burchmore, R., Mohebali, M., Mohammadi Bazargani, M., Hosseini Salekdeh, G., Kazemi-Rad, E. and Khoramizadeh, M. R. (2015) Comparative proteomic profiling of Leishmania tropica: investigation of a case infected with simultaneous cutaneous and viscerotropic leishmaniasis by 2-dimentional electrophoresis and mass spectrometry. Iranian Journal of Parasitology, 10(3), pp. 366-380.

Mudaliar, M., Thomas, F., McLaughlin, M., Burchmore, R., Wilson, D., Herzyk, P., Eckersall, P. and Zadoks, R. (2015) Using label-free quantitative proteomics and untargeted metabolomics to study bovine mastitis. In: Science with Impact – BSAS Annual Conference 2015, University of Chester, UK, 14-15 Apr 2015, p. 70. (doi:10.1017/S2040470015000023)

2014

Mudaliar, M., Thomas, F., McLaughlin, M., Burchmore, R., Herzyk, P., Eckersall, P. and Zadoks, R. (2014) Integrative label-free quantitative proteomics study in mastitis. In: Final Showcase Meeting of Farm Animal Proteomics, Milan, Italy, 17-18 Nov 2014, pp. 98-101. ISBN 9789086868100 (doi:10.3920/978-90-8686-810-0)

Beckham, K. S.H. et al. (2014) The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7. Molecular Microbiology, 93(1), pp. 199-211. (doi:10.1111/mmi.12651) (PMID:24846743) (PMCID:PMC4249723)

Shafie, I. N.F., McLaughlin, M., Burchmore, R., Lim, M. A. A., Montague, P., Johnston, P. E.J., Penderis, J. and Anderson, T. J. (2014) The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog. Cell Stress and Chaperones, 19(3), pp. 311-320. (doi:10.1007/s12192-013-0457-4)

Daneshvar, H., Mahmmodi, Z., Kamiabi, H., Phillips, R. S. and Burchmore, R. (2014) Dogs vaccinated with gentamicin-attenuated Leishmania infantum or infected with wild-type parasite can be distinguished by Western blotting. Parasite Immunology, 36(5), pp. 218-224. (doi:10.1111/pim.12108)

Kuleš, J., Mrljak, V., Rafaj, R., Selanec, J., Burchmore, R. and Eckersall, P. D. (2014) Identification of serum biomarkers in dogs naturally infected with Babesia canis canis using a proteomic approach. BMC Veterinary Research, 10(1), p. 111. (doi:10.1186/1746-6148-10-111)

Daneshvar, H., Namazi, M. J., Kamiabi, H., Burchmore, R., Cleaveland, S. and Phillips, S. (2014) Gentamicin-attenuated leishmania infantum vaccine: protection of dogs against canine visceral leishmaniosis in endemic area of southeast of Iran. PLoS Neglected Tropical Diseases, 8(4), e2757. (doi:10.1371/journal.pntd.0002757)

Munday, J. C. et al. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. Journal of Antimicrobial Chemotherapy, 69(3), pp. 651-663. (doi:10.1093/jac/dkt442) (PMID:24235095) (PMCID:PMC3922157)

Ceciliani, F., Eckersall, D., Burchmore, R. and Lecchi, C. (2014) Proteomics in veterinary medicine: applications and trends in disease pathogenesis and diagnostics. Veterinary Pathology, 51(2), pp. 351-362. (doi:10.1177/0300985813502819)

Burchmore, R. (2014) Mapping pathways to drug resistance with proteomics. Expert Review of Proteomics, 11(1), pp. 1-3. (doi:10.1586/14789450.2014.871497)

2013

Millerioux, Y. et al. (2013) The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control. Molecular Microbiology, 90(1), pp. 114-129. (doi:10.1111/mmi.12351) (PMID:23899193) (PMCID:PMC4034587)

Morrice, N. and Burchmore, R. (2013) Editorial. Journal of Proteomics, 88, pp. 1-3. (doi:10.1016/j.jprot.2013.05.035)

Roncada, P., Stipetic, L.H., Bonizzi, L., Burchmore, R.J.S. and Kennedy, M.W. (2013) Proteomics as a tool to explore human milk in health and disease. Journal of Proteomics, 88, pp. 47-57. (doi:10.1016/j.jprot.2013.04.008)

Atherton, M.J., Braceland, M., Fontaine, S., Waterston, M.M., Burchmore, R.J., Eadie, S., Eckersall, P.D. and Morris, J.S. (2013) Changes in the serum proteome of canine lymphoma identified by electrophoresis and mass spectrometry. Veterinary Journal, 196(3), pp. 320-324. (doi:10.1016/j.tvjl.2012.12.010)

Atherton, M.J., Braceland, M., Harvie, J., Burchmore, R.J., Eadie, S., Eckersall, P.D. and Morris, J.S. (2013) Characterisation of the normal canine serum proteome using a novel electrophoretic technique combined with mass spectrometry. Veterinary Journal, 196(3), pp. 315-319. (doi:10.1016/j.tvjl.2012.12.011)

Feng, X., Rodriguez-Contreras, D., Polley, T., Lye, L.-F., Scott, D., Burchmore, R.J.S., Beverley, S.M. and Landfear, S.M. (2013) 'Transient' genetic suppression facilitates generation of hexose transporter null mutants inLeishmania mexicana. Molecular Microbiology, 87(2), pp. 412-429. (doi:10.1111/mmi.12106)

Bain, M.M., McDade, K., Burchmore, R., Law, A., Wilson, P.W., Schmutz, M., Preisinger, R. and Dunn, I.C. (2013) Enhancing the egg's natural defence against bacterial penetration by increasing cuticle deposition. Animal Genetics, 44(6), pp. 661-668. (doi:10.1111/age.12071)

Kerkhoven, E. J. et al. (2013) Handling uncertainty in dynamic models: the pentose phosphate pathway in trypanosoma brucei. PLoS ONE, 9(12), e1003371. (doi:10.1371/journal.pcbi.1003371) (PMID:24339766) (PMCID:24339766)

Monnerat, S., Almeida Costa, C.I., Forkert, A.C., Benz, C., Hamilton, A., Tetley, L., Burchmore, R., Novo, C., Mottram, J.C. and Hammarton, T.C. (2013) Identification and functional characterisation of CRK12:CYC9, a novel cyclin-dependent kinase (CDK)-cyclin complex in Trypanosoma brucei. PLoS ONE, 8(6), e67327. (doi:10.1371/journal.pone.0067327) (PMID:23805309) (PMCID:PMC3689728)

O'Reilly, E.L., Burchmore, R.J., Eckersall, P.D. and Sparks, N.H.C. (2013) The effect of microbial challenge on the intestinal proteome of broiler chickens. British Poultry Abstracts, 9(1), pp. 5-6. (doi:10.1080/17466202.2013.842677)

2012

Burchmore, R. (2012) Parasites in the brain? The search for sleeping sickness biomarkers. Expert Review of Anti-Infective Therapy, 10(11), pp. 1283-1286. (doi:10.1586/ERI.12.124)

Daneshvar, H., Sedghy, F., Dabiri, S., Kamiabi, H., Molaei, M.M., Phillips, S. and Burchmore, R. (2012) Alteration in mononuclear cell subpopulations in dogs immunized with gentamicin-attenuated Leishmania infantum. Parasitology, 139(13), pp. 1689-1696. (doi:10.1017/S0031182012001187)

Burgess, K.E.V. and Burchmore, R.J.S. (2012) Strategies to dissect parasite proteomes. Parasitology, 139(9), pp. 1119-1130. (doi:10.1017/S0031182011002368)

Ginger, M.L., McKean, P.G., Burchmore, R.J.S. and Grant, K.M. (2012) Proteomic insights into parasite biology. Parasitology, 139(9), pp. 1101-1102. (doi:10.1017/S0031182012000947)

E-komon, T., Burchmore, R., Herzyk, P. and Davies, R. (2012) Predicting the outer membrane proteome of Pasteurella multocida based on consensus prediction enhanced by results integration and manual confirmation. BMC Bioinformatics, 13(1), 63. (doi:10.1186/1471-2105-13-63) (PMID:22540951) (PMCID:PMC3403877)

McNamara, L.E., Burchmore, R.J.S., Riehle, M.O. , Herzyk, P., Biggs, M.J.P., Wilkinson, C.D.W., Curtis, A.S.G. and Dalby, M.J. (2012) The role of microtopography in cellular mechanotransduction. Biomaterials, 33(10), pp. 2835-2847. (doi:10.1016/j.biomaterials.2011.11.047)

Daneshvar, H., Wyllie, S., Phillips, S., Hagan, P. and Burchmore, R. (2012) Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism. Journal of Proteomics, 75(5), pp. 1463-1471. (doi:10.1016/j.jprot.2011.11.018)

Kuboki, T., Kantawong, F., Burchmore, R., Dalby, M.J. and Kidoaki, S. (2012) 2D-DIGE proteomic analysis of mesenchymal stem cell cultured on the elasticity-tunable hydrogels. Cell Structure and Function, 37(2), pp. 127-139. (doi:10.1247/csf.12012)

McNamara, L.E., Kantawong, F., Dalby, M.J., Riehle, M.O. and Burchmore, R.J.S. (2012) Preventing and troubleshooting artefacts in saturation labelled fluorescence 2D difference gel electrophoresis (saturation DiGE). Proteomics, 11(24), pp. 4610-4621. (doi:10.1002/pmic.201100135)

Tiengwe, C., Marcello, L., Farr, H., Gadelha, C., Burchmore, R., Barry, J.D., Bell, S.D. and McCulloch, R. (2012) Identification of ORC1/CDC6-interacting factors in trypanosoma brucei reveals critical features of origin recognition complex architecture. PLoS ONE, 7(3), e32674. (doi:10.1371/journal.pone.0032674)

Vincent, I.M., Creek, D.J., Burgess, K., Woods, D.J., Burchmore, R.J.S. and Barrett, M.P. (2012) Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei. PLoS Neglected Tropical Diseases, 6(5), e1618. (doi:10.1371/journal.pntd.0001618) (PMID:22563508) (PMCID:PMC3341325)

2011

Hounsome, J. D.A., Baillie, S., Noofeli, M., Riboldi-Tunnicliffe, A., Burchmore, R. J.S., Isaacs, N. W. and Davies, R. L. (2011) Outer membrane protein A of bovine and ovine isolates of mannheimia haemolytica is surface exposed and contains host species-specific epitopes. Infection and Immunity, 79(11), pp. 4332-4341. (doi:10.1128/IAI.05469-11)

Higon, M. et al. (2011) Screening trematodes for novel intervention targets: a proteomic and immunological comparison of Schistosoma haematobium, Schistosoma bovis and Echinostoma caproni. Parasitology, 138(12), pp. 1607-1619. (doi:10.1017/S0031182011000412)

Barrett, M.P., Vincent, I.M., Burchmore, R.J.S., Kazibwe, A.J.N. and Matovu, E. (2011) Drug resistance in human African trypanosomiasis. Future Microbiology, 6(9), pp. 1037-1047. (doi:10.2217/fmb.11.88) (PMID:21958143)

Wang, D. et al. (2011) Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds. Journal of Biological Chemistry, 286(34), pp. 29922-29931. (doi:10.1074/jbc.M111.233858)

Gerou-Ferriani, M., McBrearty, A.R., Burchmore, R.J., Jayawardena, K.G.I., Eckersall, P.D. and Morris, J.S. (2011) Agarose gel serum protein electrophoresis in cats with and without lymphoma and preliminary results of tandem mass fingerprinting analysis. Veterinary Clinical Pathology, 40(2), pp. 159-173. (doi:10.1111/j.1939-165X.2011.00310.x)

Ward, C.P., Wong, P.E., Burchmore, R.J.S., De Koning, H.P. and Barrett, M.P. (2011) Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns. Antimicrobial Agents and Chemotherapy, 55(5), pp. 2352-2361. (doi:10.1128/AAC.01551-10)

2010

Naula, C.M., Logan, F.M., Wong, P.E., Barrett, M.P. and Burchmore, R.J. (2010) A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter. Journal of Biological Chemistry, 285(39), pp. 29721-29728. (doi:10.1074/jbc.M110.106815)

Kantawong, F., Burgess, K.E.V., Jayawardena, K., Hart, A., Riehle, M.O. , Oreffo, R.O., Dalby, M.J. and Burchmore, R. (2010) Effects of a surface topography composite with puerariae radix on human STRO-1-positive stem cells. Acta Biomaterialia, 6(9), pp. 3694-3703. (doi:10.1016/j.actbio.2010.02.038)

Murphy, L., Eckersall, P.D., Bishop, S.C., Pettit, J.J., Huntley, J.F., Burchmore, R.J.S. and Stear, M.J. (2010) Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta. Parasitology, 137(8), pp. 1249-1260. (doi:10.1017/S0031182010000028)

Szoor, B., Ruberto, I., Burchmore, R.J.S. and Matthews, K.R. (2010) A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway. Genes and Development, 24(12), pp. 1306-1316. (doi:10.1101/gad.570310)

Burchmore, R.J.S. (2010) Neuroproteomics. Expert Review of Proteomics, 7(3), pp. 331-332. (doi:10.1586/epr.10.17)

McNamara, L.E., Dalby, M.J., Riehle, M.O. and Burchmore, R.J.S. (2010) Fluorescence two-dimensional difference gel electrophoresis for biomaterial applications. Journal of the Royal Society: Interface, 7(Sppl 1), S107-S118. (doi:10.1098/rsif.2009.0177.focus)

Stewart, M.L. et al. (2010) Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes. Eukaryotic Cell, 9(2), pp. 336-343.

Vincent, I., Scotcher, J. and Burchmore, R. (2010) Sixth exploratory measurement science group symposium. Expert Review of Proteomics, 7(1), pp. 19-20. (doi:10.1586/epr.09.88)

Romero, I. C., Mehaffy, C., Burchmore, R. J., Dobos-Elder, K., Brennan, P. and Walker, J. (2010) Identification of promoter-binding proteins of the fbp A and C genes in Mycobacterium tuberculosis. Tuberculosis, 90(1), pp. 25-30. (doi:10.1016/j.tube.2009.10.001)

Luu, V., Brems, S., Hoheisel, J.D., Burchmore, R., Guilbride, D.L. and Clayton, C. (2010) Corrigendum to "Functional analysis of Trypanosoma brucei PUF1" [Mol. Biochem. Parasitol. 150 (2006) 340–349]. Molecular and Biochemical Parasitology, 169(1), p. 70. (doi:10.1016/j.molbiopara.2009.09.003)

Daneshevar, H., Molaei, M. M., Kamiabi, H., Burchmore, R.J.S., Hagan, P. and Phillips, R.S. (2010) Gentamicin-attenuated Leishmania infantum: cellular immunity production and protection of dogs against experimental canine leishmaniasis. Parasite Immunology, 32(11-12), pp. 722-730. (doi:10.1111/j.1365-3024.2010.01237.x)

Mutapi, F., Bourke, C., Harcus, Y., Midzi, N., Mduluza, T., Turner, C.M.R., Burchmore, R.J.S. and Maizels, R.M. (2010) Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4. Parasite Immunology, 33(3), pp. 181-192. (doi:10.1111/j.1365-3024.2010.01270.x)

Vincent, I.M., Creek, D., Watson, D.G., Kamleh, M.A., Woods, D.J., Wong, P.E., Burchmore, R.J.S. and Barrett, M.P. (2010) A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathogens, 6(11), e1001204. (doi:10.1371/journal.ppat.1001204) (PMID:21124824) (PMCID:PMC2991269)

Ward, C. P., Burgess, K. E.V., Burchmore, R.J.S., Barrett, M.P. and De Koning, H.P. (2010) A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes. Molecular and Biochemical Parasitology, 174(2), pp. 145-149. (doi:10.1016/j.molbiopara.2010.07.002)

2009

Kantawong, F., Burchmore, R.J.S., Gadegaard, N., Oreffo, R.O.C. and Dalby, M.J. (2009) Proteomic analysis of human osteoprogenitor response to disordered nanotopography. Journal of the Royal Society: Interface, (doi:10.1098/rsif.2008.0447)

Ataei, S., Burchmore, R., Hodgson, J. C., Finucane, A., Parton, R. and Coote, J. G. (2009) Identification of immunogenic proteins associated with protection against haemorrhagic septicaemia after vaccination of calves with a live-attenuated aroA derivative of Pasteurella multocida B:2. Research in Veterinary Science, 87(2), pp. 207-210. (doi:10.1016/j.rvsc.2009.01.007)

Daneshvar, H., Burchmore, R., Hagan, P. and Phillips, R. S. (2009) Leishmania major H-line attenuated under pressure of gentamicin, induces a Th1 response which protects susceptible BALB/c mice against infection with virulent L. major. Parasitology, 136(11), pp. 1243-1250. (doi:10.1017/S0031182009990679)

Kantawong, F., Burgess, K.E.V., Jayawardena, K., Hart, A., Burchmore, R.J., Gadegaard, N., Oreffo, R.O.C. and Dalby, M.J. (2009) Whole proteome analysis of osteoprogenitor differentiation induced by disordered nanotopography and mediated by ERK signalling. Biomaterials, 30(27), pp. 4723-4731. (doi:10.1016/j.biomaterials.2009.05.040)

Rossi, L., Riehle, M.O. , McNamara, L.E., Burchmore, R., Dalby, M.J., McMurray, R.J., Gadegaard, N., Ahmed, S. and Tsimbouri, P.M. (2009) Research highlights. Nanomedicine, 4(6), pp. 613-617. (doi:10.2217/nnm.09.46)

Kantawong, F., Burchmore, R.J.S., Wilkinson, C.D.W., Oreffo, R.O.C. and Dalby, M.J. (2009) Differential in-gel electrophoresis (DIGE) analysis of human bone marrow osteoprogenitor cell contact guidance. Acta Biomaterialia, 5(4), pp. 1137-1146. (doi:10.1016/j.actbio.2008.11.001)

Daneshvar, H., Molaei, M.M., Afshar, R.M., Kamiabi, H., Burchmore, R.J.S., Hagan, P. and Phillips, R.S. (2009) Gentamicin-attenuated Leishmania infantum: A clinicopathological study in dogs. Veterinary Immunology and Immunopathology, 129(1-2), pp. 28-35. (doi:10.1016/j.vetimm.2008.12.002)

2008

Dalby, M.J., McNamara, L.E., Riehle, M.O. , Burchmore, R.J.S., Kuntanawat, P., McMurray, R.J., Gadegaard, N. and Andar, A. (2008) Research highlights. Nanomedicine, 3(4), pp. 411-414. (doi:10.2217/17435889.3.4.411)

Mutapi, F., Burchmore, R., Mduluza, T., Midzi, N., Turner, C. M. R. and Maizels, R. M. (2008) Age‐related and infection intensity–related shifts in antibody recognition of defined protein antigens in a schistosome‐exposed population. Journal of Infectious Diseases, 198(2), pp. 167-175. (doi:10.1086/589511)

Kamleh, A., Barrett, M.P., Wildridge, D., Burchmore, R.J.S., Scheltema, R.A.. and Watson, D.G. (2008) Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules. Rapid Communications in Mass Spectrometry, 22(12), pp. 1912-1918. (doi:10.1002/rcm.3564)

Bridges, D.J., Pitt, A.R., Hanrahan, O., Brennan, K., Voorheis, H.P., Herzyk, P., de Koning, H.P. and Burchmore, R.J.S. (2008) Characterisation of the plasma membrane subproteome of bloodstream form Trypanosoma brucei. Proteomics, 8(1), pp. 83-99. (doi:10.1002/pmic.200700607)

2007

Bridges, D. J., Gould, M. K., Nerima, B., Maser, P., Burchmore, R. J. S. and de Koning, H. P. (2007) Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes. Molecular Pharmacology, 71, pp. 1098-1108. (doi:10.1124/mol.106.031351)

Hannigan, A., Burchmore, R. and Wilson, J. (2007) The optimization of Protocols for Proteome difference gel electrophoresis (DiGE) analysis of Preneoplastic skin. Journal of Proteome Research, 6, pp. 3422-3432. (doi:10.1021/pr0606878)

Naula, C., Alibu, V., Brock, J., Veitch, N.J., Burchmore, R.J.S. and Barrett, M. (2007) A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase. Journal of Biochemical and Biophysical Methods, 70(6), pp. 1185-1187. (doi:10.1016/j.jprot.2007.11.002)

Nelson, M.M., Jones, A.R., Carmen, J.C., Sinai, A.P.,, Burchmore, R. and Wastling, J.M. (2007) Modulation of the host cell proteome by the intracellular apicomplexan parasite Toxoplasma gondii. Infection and Immunity, 76(2), pp. 828-844. (doi:10.1128/IAI.01115-07)

2006

Luu, V.D., Brems, S., Hoheisel, J.D., Burchmore, R., Guilbride, D.L. and Clayton, C. (2006) Functional analysis of Trypanosoma brucei PUF1. Molecular and Biochemical Parasitology, 150(2), pp. 340-349. (doi:10.1016/j.molbiopara.2006.09.007)

Burchmore, R. (2006) Identification of anti-infective targets through comparative proteomics. Expert Review of Anti-Infective Therapy, 4(2), pp. 163-165. (doi:10.1586/14787210.4.2.163)

Walker, J., Vasquez, J., Gomez, M., Drummelsmith, J., Burchmore, R., Girard, I. and Ouellette, M. (2006) Identification of developmentally-regulated proteins in Leishmania panamensis promastigotes and by proteome profiling of axenic amastigotes. Molecular and Biochemical Parasitology, 147, pp. 64-73. (doi:10.1016/j.molbiopara.2006.01.008)

2005

De Koning, H. P. , Bridges, D. J. and Burchmore, R. J. S. (2005) Purine and pyrimidine transport in pathogenic protozoa: From biology to therapy. FEMS Microbiology Reviews, 29(5), pp. 987-1020. (doi:10.1016/j.femsre.2005.03.004)

Mutapi, F., Burchmore, R., Mduluza, T., Foucher, A., Harcus, Y., Nicoll, G., Midzi, N., Turner, C. and Maizels, R. (2005) Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined parasite antigens. Journal of Infectious Diseases, 192, pp. 1108-1118.

Stewart, M., Krishna, S., Burchmore, R., Brun, R., de Koning, H. , Boykin, D., Tidwell, R., Hall, J. and Barrett, M. (2005) Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet, 366, pp. 486-487. (doi:10.1016/S0140-6736(05)66793-1)

2004

de Koning, H., Anderson, L., Stewart, M., Burchmore, R., Wallace, L. and Barrett, M. (2004) The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in African trypanosomes. Antimicrobial Agents and Chemotherapy, 48, pp. 1515-1519. (doi:10.1128/AAC.48.5.1515-1519.2004)

2003

Barrett, M., Burchmore, R., Stich, A., Lazzari, J., Frasch, A., Cazzulo, J. and Krishna, S. (2003) The trypanosomiases. Lancet, 362(9394), pp. 1469-1480. (doi:10.1016/S0140-6736(03)14694-6)

Burchmore, R. (2003) A plethora of targets, a paucity of drugs: Progress towards the development of novel chemotherapies for human African trypanosomiasis. Expert Review of Anti-Infective Therapy, 1(1), pp. 157-165. (doi:10.1586/14787210.1.1.157)

Burchmore, R., Rodriguez-Contreras, D., McBride, K., Barrett, M., Modi, G., Sacks, D. and Landfear, S. (2003) Genetic characterization of glucose transporter function in Leishmania mexicana. Proceedings of the National Academy of Sciences of the United States of America, 100(7), pp. 3901-3906. (doi:10.1073/pnas.0630165100)

Burchmore, R., Wallace, L., Candlish, D., Al-Salabi, M., Beal, P., Barrett, M., Baldwin, S. and de Koning, H. (2003) Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan. Journal of Biological Chemistry, 278(26), pp. 23502-23507. (doi:10.1074/jbc.M301252200)

Matovu, E. et al. (2003) Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryotic Cell, 2(5), pp. 1003-1008. (doi:10.1128/EC.2.5.1003-1008.2003)

Maugeri, D., Cazzulo, J., Burchmore, R., Barrett, M. and Ogbunude, P. (2003) Pentose phosphate metabolism in Leishmania mexicana. Molecular and Biochemical Parasitology, 130(2), pp. 117-125. (doi:10.1016/S0166-6851(03)00173-7)

2002

Leslie, G., Barrett, M. and Burchmore, R. (2002) Leishmania mexicana: promastigotes migrate through osmotic gradients. Experimental Parasitology, 102(2), pp. 117-120. (doi:10.1016/S0014-4894(03)00031-6)

Burchmore, R., Ogbunude, P., Enanga, B. and Barrett, M. (2002) Chemotherapy of human African trypanosomiasis. Current Pharmaceutical Design, 8(4), pp. 257-267. (doi:10.2174/1381612023396159)

Enanga, B., Burchmore, R., Stewart, M. and Barrett, M. (2002) Sleeping sickness and the brain. Cellular and Molecular Life Sciences, 59(5), pp. 845-858. (doi:10.1007/s00018-002-8472-0)

2001

Burchmore, R. and Barrett, M. (2001) Life in vacuoles - nutrient acquisition by Leishmania amastigotes. International Journal for Parasitology, 31(12), pp. 1311-1320. (doi:10.1016/S0020-7519(01)00259-4)

This list was generated on Mon Sep 18 23:23:05 2017 BST.
Number of items: 102.

Articles

Martinez-Subiela, S., Horvatic, A., Escribano, D., Pardo-Marin, L., Kocaturk, M., Mrljak, V., Burchmore, R., Ceron, J. J. and Yilmaz, Z. (2017) Identification of novel biomarkers for treatment monitoring in canine leishmaniosis by high-resolution quantitative proteomic analysis. Veterinary Immunology and Immunopathology, 191, pp. 60-67. (doi:10.1016/j.vetimm.2017.08.004) (PMID:28895868)

Mwenechanya, R. et al. (2017) Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana. PLoS Neglected Tropical Diseases, 11(6), e0005649. (doi:10.1371/journal.pntd.0005649) (PMID:28622334)

Rojas, F., Koszela, J., Búa, J., Llorente, B., Burchmore, R., Auer, M., Mottram, J. C. and Téllez-Iñón, M. T. (2017) The ubiquitin-conjugating enzyme CDC34 is essential for cytokinesis in contrast to putative subunits of a SCF complex in Trypanosoma brucei. PLoS Neglected Tropical Diseases, 11(6), e0005626. (doi:10.1371/journal.pntd.0005626) (PMID:28609481)

Hulme, H. E. et al. (2017) Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection. Scientific Reports, 7, 2786. (doi:10.1038/s41598-017-03100-5)

O'Reilly, E. L., Burchmore, R. J., Sparks, N. H. and Eckersall, P. D. (2017) The effect of microbial challenge on the intestinal proteome of broiler chickens. Proteome Science, 15, 10. (doi:10.1186/s12953-017-0118-0) (PMID:28572745) (PMCID:PMC5450085)

Marcos-López, M., Rodger, H. D., O'Connor, I., Braceland, M., Burchmore, R. J.S., Eckersall, P. and MacCarthy, E. (2017) A proteomic approach to assess the host response in gills of farmed Atlantic salmon Salmo salar L. affected by amoebic gill disease. Aquaculture, 470, pp. 1-10. (doi:10.1016/j.aquaculture.2016.12.009)

Lindeberg, H. , Burchmore, R. J.S. and Kennedy, M. W. (2017) Pulse of inflammatory proteins in the pregnant uterus of European polecats (Mustela putorius) leading to the time of implantation. Royal Society Open Science, 4(3), 161085. (doi:10.1098/rsos.161085) (PMID:28405395) (PMCID:PMC5383852)

Akpunarlieva, S., Weidt, S., Lamasudin, D., Naula, C., Henderson, D., Barrett, M. , Burgess, K. and Burchmore, R. (2017) Integration of proteomics and metabolomics to elucidate metabolic adaptation in Leishmania. Journal of Proteomics, 155, pp. 85-98. (doi:10.1016/j.jprot.2016.12.009) (PMID:28040509)

Schrama, D., Richard, N., Silva, T. S., Figueiredo, F. A., Conceição, L. E.C., Burchmore, R., Eckersall, D. and Rodrigues, P. M.L. (2016) Enhanced dietary formulation to mitigate winter thermal stress in gilthead sea bream (Sparus aurata): a 2D-DIGE plasma proteome study. Fish Physiology and Biochemistry, (doi:10.1007/s10695-016-0315-2) (PMID:27882445) (Early Online Publication)

Lobo-Rojas, Á. E., González-Marcano, E. B., Valera-Vera, E. A., Acosta, H. R., Quiñones, W. A., Burchmore, R. J.S., Concepción, J. L. and Cáceres, A. J. (2016) Trypanosoma cruzi contains two galactokinases; molecular and biochemical characterization. Parasitology International, 65(5 Pt A), pp. 472-482. (doi:10.1016/j.parint.2016.06.008) (PMID:27312997)

Ormsby, M. J., Caws, T., Burchmore, R., Wallis, T., Verner-Jeffreys, D. W. and Davies, R. L. (2016) Yersinia ruckeri isolates recovered from diseased Atlantic Salmon (Salmo salar) in Scotland are more diverse than those from Rainbow Trout (Oncorhynchus mykiss) and represent distinct subpopulations. Applied and Environmental Microbiology, 82(19), pp. 5785-5794. (doi:10.1128/aem.01173-16) (PMID:27451448)

Mudaliar, M. et al. (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 2. Label-free relative quantitative proteomics. Molecular BioSystems, 12(9), pp. 2748-2761. (doi:10.1039/C6MB00290K) (PMID:27412694) (PMCID:PMC5048399)

Thomas, F., Mudaliar, M. , Tassi, R., Mcneilly, T., Burchmore, R., Burgess, K., Herzyk, P., Zadoks, R. and Eckersall, P. (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 3. Untargeted metabolomics. Molecular BioSystems, 12(9), pp. 2762-2769. (doi:10.1039/C6MB00289G) (PMID:27412568)

Thomas, F., Mullen, W. , Tassi, R., Ramírez-Torres, A., Mudaliar, M. , Mcneilly, T., Zadoks, R., Burchmore, R. and Eckersall, P. (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 1. High abundance proteins, acute phase proteins and peptidomics. Molecular BioSystems, 12(9), pp. 2735-2747. (doi:10.1039/C6MB00239K) (PMID:27412456) (PMCID:PMC5048397)

Grewal, J. S. et al. (2016) PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast. Journal of Biological Chemistry, 291, pp. 9492-9500. (doi:10.1074/jbc.M116.714972) (PMID:26940875) (PMCID:PMC4850289)

Griffiths, K., Rong, H., Wang, H., Zhang, Z., Zhang, T., Watson, D. G., Burchmore, R., Loeffler, I.K. and Kennedy, M. (2015) Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca. Royal Society Open Science, 2, 150395. (doi:10.1098/rsos.150395)

Haggarty, J., Oppermann, M., Dalby, M. J., Burchmore, R. J., Cook, K., Weidt, S. and Burgess, K. E.V. (2015) Serially coupling hydrophobic interaction and reversed-phase chromatography with simultaneous gradients provides greater coverage of the metabolome. Metabolomics, 11(5), pp. 1465-1470. (doi:10.1007/s11306-014-0770-7) (PMID:26366140) (PMCID:PMC4559102)

Fyfe, C.D., Grinter, R., Josts, I., Mosbahi, K., Roszak, A.W., Cogdell, R.J., Wall, D.M., Burchmore, R.J.S., Byron, O. and Walker, D. (2015) Structure of protease-cleaved escherichia coliα-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment. Acta Crystallographica. Section D: Biological Crystallography, 71(7), pp. 1478-1486. (doi:10.1107/s1399004715008548) (PMID:26143919) (PMCID:PMC4498604)

Hajjaran, H., Mousavi, P., Burchmore, R., Mohebali, M., Mohammadi Bazargani, M., Hosseini Salekdeh, G., Kazemi-Rad, E. and Khoramizadeh, M. R. (2015) Comparative proteomic profiling of Leishmania tropica: investigation of a case infected with simultaneous cutaneous and viscerotropic leishmaniasis by 2-dimentional electrophoresis and mass spectrometry. Iranian Journal of Parasitology, 10(3), pp. 366-380.

Beckham, K. S.H. et al. (2014) The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7. Molecular Microbiology, 93(1), pp. 199-211. (doi:10.1111/mmi.12651) (PMID:24846743) (PMCID:PMC4249723)

Shafie, I. N.F., McLaughlin, M., Burchmore, R., Lim, M. A. A., Montague, P., Johnston, P. E.J., Penderis, J. and Anderson, T. J. (2014) The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog. Cell Stress and Chaperones, 19(3), pp. 311-320. (doi:10.1007/s12192-013-0457-4)

Daneshvar, H., Mahmmodi, Z., Kamiabi, H., Phillips, R. S. and Burchmore, R. (2014) Dogs vaccinated with gentamicin-attenuated Leishmania infantum or infected with wild-type parasite can be distinguished by Western blotting. Parasite Immunology, 36(5), pp. 218-224. (doi:10.1111/pim.12108)

Kuleš, J., Mrljak, V., Rafaj, R., Selanec, J., Burchmore, R. and Eckersall, P. D. (2014) Identification of serum biomarkers in dogs naturally infected with Babesia canis canis using a proteomic approach. BMC Veterinary Research, 10(1), p. 111. (doi:10.1186/1746-6148-10-111)

Daneshvar, H., Namazi, M. J., Kamiabi, H., Burchmore, R., Cleaveland, S. and Phillips, S. (2014) Gentamicin-attenuated leishmania infantum vaccine: protection of dogs against canine visceral leishmaniosis in endemic area of southeast of Iran. PLoS Neglected Tropical Diseases, 8(4), e2757. (doi:10.1371/journal.pntd.0002757)

Munday, J. C. et al. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. Journal of Antimicrobial Chemotherapy, 69(3), pp. 651-663. (doi:10.1093/jac/dkt442) (PMID:24235095) (PMCID:PMC3922157)

Ceciliani, F., Eckersall, D., Burchmore, R. and Lecchi, C. (2014) Proteomics in veterinary medicine: applications and trends in disease pathogenesis and diagnostics. Veterinary Pathology, 51(2), pp. 351-362. (doi:10.1177/0300985813502819)

Burchmore, R. (2014) Mapping pathways to drug resistance with proteomics. Expert Review of Proteomics, 11(1), pp. 1-3. (doi:10.1586/14789450.2014.871497)

Millerioux, Y. et al. (2013) The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control. Molecular Microbiology, 90(1), pp. 114-129. (doi:10.1111/mmi.12351) (PMID:23899193) (PMCID:PMC4034587)

Morrice, N. and Burchmore, R. (2013) Editorial. Journal of Proteomics, 88, pp. 1-3. (doi:10.1016/j.jprot.2013.05.035)

Roncada, P., Stipetic, L.H., Bonizzi, L., Burchmore, R.J.S. and Kennedy, M.W. (2013) Proteomics as a tool to explore human milk in health and disease. Journal of Proteomics, 88, pp. 47-57. (doi:10.1016/j.jprot.2013.04.008)

Atherton, M.J., Braceland, M., Fontaine, S., Waterston, M.M., Burchmore, R.J., Eadie, S., Eckersall, P.D. and Morris, J.S. (2013) Changes in the serum proteome of canine lymphoma identified by electrophoresis and mass spectrometry. Veterinary Journal, 196(3), pp. 320-324. (doi:10.1016/j.tvjl.2012.12.010)

Atherton, M.J., Braceland, M., Harvie, J., Burchmore, R.J., Eadie, S., Eckersall, P.D. and Morris, J.S. (2013) Characterisation of the normal canine serum proteome using a novel electrophoretic technique combined with mass spectrometry. Veterinary Journal, 196(3), pp. 315-319. (doi:10.1016/j.tvjl.2012.12.011)

Feng, X., Rodriguez-Contreras, D., Polley, T., Lye, L.-F., Scott, D., Burchmore, R.J.S., Beverley, S.M. and Landfear, S.M. (2013) 'Transient' genetic suppression facilitates generation of hexose transporter null mutants inLeishmania mexicana. Molecular Microbiology, 87(2), pp. 412-429. (doi:10.1111/mmi.12106)

Bain, M.M., McDade, K., Burchmore, R., Law, A., Wilson, P.W., Schmutz, M., Preisinger, R. and Dunn, I.C. (2013) Enhancing the egg's natural defence against bacterial penetration by increasing cuticle deposition. Animal Genetics, 44(6), pp. 661-668. (doi:10.1111/age.12071)

Kerkhoven, E. J. et al. (2013) Handling uncertainty in dynamic models: the pentose phosphate pathway in trypanosoma brucei. PLoS ONE, 9(12), e1003371. (doi:10.1371/journal.pcbi.1003371) (PMID:24339766) (PMCID:24339766)

Monnerat, S., Almeida Costa, C.I., Forkert, A.C., Benz, C., Hamilton, A., Tetley, L., Burchmore, R., Novo, C., Mottram, J.C. and Hammarton, T.C. (2013) Identification and functional characterisation of CRK12:CYC9, a novel cyclin-dependent kinase (CDK)-cyclin complex in Trypanosoma brucei. PLoS ONE, 8(6), e67327. (doi:10.1371/journal.pone.0067327) (PMID:23805309) (PMCID:PMC3689728)

O'Reilly, E.L., Burchmore, R.J., Eckersall, P.D. and Sparks, N.H.C. (2013) The effect of microbial challenge on the intestinal proteome of broiler chickens. British Poultry Abstracts, 9(1), pp. 5-6. (doi:10.1080/17466202.2013.842677)

Burchmore, R. (2012) Parasites in the brain? The search for sleeping sickness biomarkers. Expert Review of Anti-Infective Therapy, 10(11), pp. 1283-1286. (doi:10.1586/ERI.12.124)

Daneshvar, H., Sedghy, F., Dabiri, S., Kamiabi, H., Molaei, M.M., Phillips, S. and Burchmore, R. (2012) Alteration in mononuclear cell subpopulations in dogs immunized with gentamicin-attenuated Leishmania infantum. Parasitology, 139(13), pp. 1689-1696. (doi:10.1017/S0031182012001187)

Burgess, K.E.V. and Burchmore, R.J.S. (2012) Strategies to dissect parasite proteomes. Parasitology, 139(9), pp. 1119-1130. (doi:10.1017/S0031182011002368)

Ginger, M.L., McKean, P.G., Burchmore, R.J.S. and Grant, K.M. (2012) Proteomic insights into parasite biology. Parasitology, 139(9), pp. 1101-1102. (doi:10.1017/S0031182012000947)

E-komon, T., Burchmore, R., Herzyk, P. and Davies, R. (2012) Predicting the outer membrane proteome of Pasteurella multocida based on consensus prediction enhanced by results integration and manual confirmation. BMC Bioinformatics, 13(1), 63. (doi:10.1186/1471-2105-13-63) (PMID:22540951) (PMCID:PMC3403877)

McNamara, L.E., Burchmore, R.J.S., Riehle, M.O. , Herzyk, P., Biggs, M.J.P., Wilkinson, C.D.W., Curtis, A.S.G. and Dalby, M.J. (2012) The role of microtopography in cellular mechanotransduction. Biomaterials, 33(10), pp. 2835-2847. (doi:10.1016/j.biomaterials.2011.11.047)

Daneshvar, H., Wyllie, S., Phillips, S., Hagan, P. and Burchmore, R. (2012) Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism. Journal of Proteomics, 75(5), pp. 1463-1471. (doi:10.1016/j.jprot.2011.11.018)

Kuboki, T., Kantawong, F., Burchmore, R., Dalby, M.J. and Kidoaki, S. (2012) 2D-DIGE proteomic analysis of mesenchymal stem cell cultured on the elasticity-tunable hydrogels. Cell Structure and Function, 37(2), pp. 127-139. (doi:10.1247/csf.12012)

McNamara, L.E., Kantawong, F., Dalby, M.J., Riehle, M.O. and Burchmore, R.J.S. (2012) Preventing and troubleshooting artefacts in saturation labelled fluorescence 2D difference gel electrophoresis (saturation DiGE). Proteomics, 11(24), pp. 4610-4621. (doi:10.1002/pmic.201100135)

Tiengwe, C., Marcello, L., Farr, H., Gadelha, C., Burchmore, R., Barry, J.D., Bell, S.D. and McCulloch, R. (2012) Identification of ORC1/CDC6-interacting factors in trypanosoma brucei reveals critical features of origin recognition complex architecture. PLoS ONE, 7(3), e32674. (doi:10.1371/journal.pone.0032674)

Vincent, I.M., Creek, D.J., Burgess, K., Woods, D.J., Burchmore, R.J.S. and Barrett, M.P. (2012) Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei. PLoS Neglected Tropical Diseases, 6(5), e1618. (doi:10.1371/journal.pntd.0001618) (PMID:22563508) (PMCID:PMC3341325)

Hounsome, J. D.A., Baillie, S., Noofeli, M., Riboldi-Tunnicliffe, A., Burchmore, R. J.S., Isaacs, N. W. and Davies, R. L. (2011) Outer membrane protein A of bovine and ovine isolates of mannheimia haemolytica is surface exposed and contains host species-specific epitopes. Infection and Immunity, 79(11), pp. 4332-4341. (doi:10.1128/IAI.05469-11)

Higon, M. et al. (2011) Screening trematodes for novel intervention targets: a proteomic and immunological comparison of Schistosoma haematobium, Schistosoma bovis and Echinostoma caproni. Parasitology, 138(12), pp. 1607-1619. (doi:10.1017/S0031182011000412)

Barrett, M.P., Vincent, I.M., Burchmore, R.J.S., Kazibwe, A.J.N. and Matovu, E. (2011) Drug resistance in human African trypanosomiasis. Future Microbiology, 6(9), pp. 1037-1047. (doi:10.2217/fmb.11.88) (PMID:21958143)

Wang, D. et al. (2011) Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds. Journal of Biological Chemistry, 286(34), pp. 29922-29931. (doi:10.1074/jbc.M111.233858)

Gerou-Ferriani, M., McBrearty, A.R., Burchmore, R.J., Jayawardena, K.G.I., Eckersall, P.D. and Morris, J.S. (2011) Agarose gel serum protein electrophoresis in cats with and without lymphoma and preliminary results of tandem mass fingerprinting analysis. Veterinary Clinical Pathology, 40(2), pp. 159-173. (doi:10.1111/j.1939-165X.2011.00310.x)

Ward, C.P., Wong, P.E., Burchmore, R.J.S., De Koning, H.P. and Barrett, M.P. (2011) Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns. Antimicrobial Agents and Chemotherapy, 55(5), pp. 2352-2361. (doi:10.1128/AAC.01551-10)

Naula, C.M., Logan, F.M., Wong, P.E., Barrett, M.P. and Burchmore, R.J. (2010) A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter. Journal of Biological Chemistry, 285(39), pp. 29721-29728. (doi:10.1074/jbc.M110.106815)

Kantawong, F., Burgess, K.E.V., Jayawardena, K., Hart, A., Riehle, M.O. , Oreffo, R.O., Dalby, M.J. and Burchmore, R. (2010) Effects of a surface topography composite with puerariae radix on human STRO-1-positive stem cells. Acta Biomaterialia, 6(9), pp. 3694-3703. (doi:10.1016/j.actbio.2010.02.038)

Murphy, L., Eckersall, P.D., Bishop, S.C., Pettit, J.J., Huntley, J.F., Burchmore, R.J.S. and Stear, M.J. (2010) Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta. Parasitology, 137(8), pp. 1249-1260. (doi:10.1017/S0031182010000028)

Szoor, B., Ruberto, I., Burchmore, R.J.S. and Matthews, K.R. (2010) A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway. Genes and Development, 24(12), pp. 1306-1316. (doi:10.1101/gad.570310)

Burchmore, R.J.S. (2010) Neuroproteomics. Expert Review of Proteomics, 7(3), pp. 331-332. (doi:10.1586/epr.10.17)

McNamara, L.E., Dalby, M.J., Riehle, M.O. and Burchmore, R.J.S. (2010) Fluorescence two-dimensional difference gel electrophoresis for biomaterial applications. Journal of the Royal Society: Interface, 7(Sppl 1), S107-S118. (doi:10.1098/rsif.2009.0177.focus)

Stewart, M.L. et al. (2010) Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes. Eukaryotic Cell, 9(2), pp. 336-343.

Vincent, I., Scotcher, J. and Burchmore, R. (2010) Sixth exploratory measurement science group symposium. Expert Review of Proteomics, 7(1), pp. 19-20. (doi:10.1586/epr.09.88)

Romero, I. C., Mehaffy, C., Burchmore, R. J., Dobos-Elder, K., Brennan, P. and Walker, J. (2010) Identification of promoter-binding proteins of the fbp A and C genes in Mycobacterium tuberculosis. Tuberculosis, 90(1), pp. 25-30. (doi:10.1016/j.tube.2009.10.001)

Luu, V., Brems, S., Hoheisel, J.D., Burchmore, R., Guilbride, D.L. and Clayton, C. (2010) Corrigendum to "Functional analysis of Trypanosoma brucei PUF1" [Mol. Biochem. Parasitol. 150 (2006) 340–349]. Molecular and Biochemical Parasitology, 169(1), p. 70. (doi:10.1016/j.molbiopara.2009.09.003)

Daneshevar, H., Molaei, M. M., Kamiabi, H., Burchmore, R.J.S., Hagan, P. and Phillips, R.S. (2010) Gentamicin-attenuated Leishmania infantum: cellular immunity production and protection of dogs against experimental canine leishmaniasis. Parasite Immunology, 32(11-12), pp. 722-730. (doi:10.1111/j.1365-3024.2010.01237.x)

Mutapi, F., Bourke, C., Harcus, Y., Midzi, N., Mduluza, T., Turner, C.M.R., Burchmore, R.J.S. and Maizels, R.M. (2010) Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4. Parasite Immunology, 33(3), pp. 181-192. (doi:10.1111/j.1365-3024.2010.01270.x)

Vincent, I.M., Creek, D., Watson, D.G., Kamleh, M.A., Woods, D.J., Wong, P.E., Burchmore, R.J.S. and Barrett, M.P. (2010) A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathogens, 6(11), e1001204. (doi:10.1371/journal.ppat.1001204) (PMID:21124824) (PMCID:PMC2991269)

Ward, C. P., Burgess, K. E.V., Burchmore, R.J.S., Barrett, M.P. and De Koning, H.P. (2010) A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes. Molecular and Biochemical Parasitology, 174(2), pp. 145-149. (doi:10.1016/j.molbiopara.2010.07.002)

Kantawong, F., Burchmore, R.J.S., Gadegaard, N., Oreffo, R.O.C. and Dalby, M.J. (2009) Proteomic analysis of human osteoprogenitor response to disordered nanotopography. Journal of the Royal Society: Interface, (doi:10.1098/rsif.2008.0447)

Ataei, S., Burchmore, R., Hodgson, J. C., Finucane, A., Parton, R. and Coote, J. G. (2009) Identification of immunogenic proteins associated with protection against haemorrhagic septicaemia after vaccination of calves with a live-attenuated aroA derivative of Pasteurella multocida B:2. Research in Veterinary Science, 87(2), pp. 207-210. (doi:10.1016/j.rvsc.2009.01.007)

Daneshvar, H., Burchmore, R., Hagan, P. and Phillips, R. S. (2009) Leishmania major H-line attenuated under pressure of gentamicin, induces a Th1 response which protects susceptible BALB/c mice against infection with virulent L. major. Parasitology, 136(11), pp. 1243-1250. (doi:10.1017/S0031182009990679)

Kantawong, F., Burgess, K.E.V., Jayawardena, K., Hart, A., Burchmore, R.J., Gadegaard, N., Oreffo, R.O.C. and Dalby, M.J. (2009) Whole proteome analysis of osteoprogenitor differentiation induced by disordered nanotopography and mediated by ERK signalling. Biomaterials, 30(27), pp. 4723-4731. (doi:10.1016/j.biomaterials.2009.05.040)

Rossi, L., Riehle, M.O. , McNamara, L.E., Burchmore, R., Dalby, M.J., McMurray, R.J., Gadegaard, N., Ahmed, S. and Tsimbouri, P.M. (2009) Research highlights. Nanomedicine, 4(6), pp. 613-617. (doi:10.2217/nnm.09.46)

Kantawong, F., Burchmore, R.J.S., Wilkinson, C.D.W., Oreffo, R.O.C. and Dalby, M.J. (2009) Differential in-gel electrophoresis (DIGE) analysis of human bone marrow osteoprogenitor cell contact guidance. Acta Biomaterialia, 5(4), pp. 1137-1146. (doi:10.1016/j.actbio.2008.11.001)

Daneshvar, H., Molaei, M.M., Afshar, R.M., Kamiabi, H., Burchmore, R.J.S., Hagan, P. and Phillips, R.S. (2009) Gentamicin-attenuated Leishmania infantum: A clinicopathological study in dogs. Veterinary Immunology and Immunopathology, 129(1-2), pp. 28-35. (doi:10.1016/j.vetimm.2008.12.002)

Dalby, M.J., McNamara, L.E., Riehle, M.O. , Burchmore, R.J.S., Kuntanawat, P., McMurray, R.J., Gadegaard, N. and Andar, A. (2008) Research highlights. Nanomedicine, 3(4), pp. 411-414. (doi:10.2217/17435889.3.4.411)

Mutapi, F., Burchmore, R., Mduluza, T., Midzi, N., Turner, C. M. R. and Maizels, R. M. (2008) Age‐related and infection intensity–related shifts in antibody recognition of defined protein antigens in a schistosome‐exposed population. Journal of Infectious Diseases, 198(2), pp. 167-175. (doi:10.1086/589511)

Kamleh, A., Barrett, M.P., Wildridge, D., Burchmore, R.J.S., Scheltema, R.A.. and Watson, D.G. (2008) Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules. Rapid Communications in Mass Spectrometry, 22(12), pp. 1912-1918. (doi:10.1002/rcm.3564)

Bridges, D.J., Pitt, A.R., Hanrahan, O., Brennan, K., Voorheis, H.P., Herzyk, P., de Koning, H.P. and Burchmore, R.J.S. (2008) Characterisation of the plasma membrane subproteome of bloodstream form Trypanosoma brucei. Proteomics, 8(1), pp. 83-99. (doi:10.1002/pmic.200700607)

Bridges, D. J., Gould, M. K., Nerima, B., Maser, P., Burchmore, R. J. S. and de Koning, H. P. (2007) Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes. Molecular Pharmacology, 71, pp. 1098-1108. (doi:10.1124/mol.106.031351)

Hannigan, A., Burchmore, R. and Wilson, J. (2007) The optimization of Protocols for Proteome difference gel electrophoresis (DiGE) analysis of Preneoplastic skin. Journal of Proteome Research, 6, pp. 3422-3432. (doi:10.1021/pr0606878)

Naula, C., Alibu, V., Brock, J., Veitch, N.J., Burchmore, R.J.S. and Barrett, M. (2007) A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase. Journal of Biochemical and Biophysical Methods, 70(6), pp. 1185-1187. (doi:10.1016/j.jprot.2007.11.002)

Nelson, M.M., Jones, A.R., Carmen, J.C., Sinai, A.P.,, Burchmore, R. and Wastling, J.M. (2007) Modulation of the host cell proteome by the intracellular apicomplexan parasite Toxoplasma gondii. Infection and Immunity, 76(2), pp. 828-844. (doi:10.1128/IAI.01115-07)

Luu, V.D., Brems, S., Hoheisel, J.D., Burchmore, R., Guilbride, D.L. and Clayton, C. (2006) Functional analysis of Trypanosoma brucei PUF1. Molecular and Biochemical Parasitology, 150(2), pp. 340-349. (doi:10.1016/j.molbiopara.2006.09.007)

Burchmore, R. (2006) Identification of anti-infective targets through comparative proteomics. Expert Review of Anti-Infective Therapy, 4(2), pp. 163-165. (doi:10.1586/14787210.4.2.163)

Walker, J., Vasquez, J., Gomez, M., Drummelsmith, J., Burchmore, R., Girard, I. and Ouellette, M. (2006) Identification of developmentally-regulated proteins in Leishmania panamensis promastigotes and by proteome profiling of axenic amastigotes. Molecular and Biochemical Parasitology, 147, pp. 64-73. (doi:10.1016/j.molbiopara.2006.01.008)

De Koning, H. P. , Bridges, D. J. and Burchmore, R. J. S. (2005) Purine and pyrimidine transport in pathogenic protozoa: From biology to therapy. FEMS Microbiology Reviews, 29(5), pp. 987-1020. (doi:10.1016/j.femsre.2005.03.004)

Mutapi, F., Burchmore, R., Mduluza, T., Foucher, A., Harcus, Y., Nicoll, G., Midzi, N., Turner, C. and Maizels, R. (2005) Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined parasite antigens. Journal of Infectious Diseases, 192, pp. 1108-1118.

Stewart, M., Krishna, S., Burchmore, R., Brun, R., de Koning, H. , Boykin, D., Tidwell, R., Hall, J. and Barrett, M. (2005) Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet, 366, pp. 486-487. (doi:10.1016/S0140-6736(05)66793-1)

de Koning, H., Anderson, L., Stewart, M., Burchmore, R., Wallace, L. and Barrett, M. (2004) The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in African trypanosomes. Antimicrobial Agents and Chemotherapy, 48, pp. 1515-1519. (doi:10.1128/AAC.48.5.1515-1519.2004)

Barrett, M., Burchmore, R., Stich, A., Lazzari, J., Frasch, A., Cazzulo, J. and Krishna, S. (2003) The trypanosomiases. Lancet, 362(9394), pp. 1469-1480. (doi:10.1016/S0140-6736(03)14694-6)

Burchmore, R. (2003) A plethora of targets, a paucity of drugs: Progress towards the development of novel chemotherapies for human African trypanosomiasis. Expert Review of Anti-Infective Therapy, 1(1), pp. 157-165. (doi:10.1586/14787210.1.1.157)

Burchmore, R., Rodriguez-Contreras, D., McBride, K., Barrett, M., Modi, G., Sacks, D. and Landfear, S. (2003) Genetic characterization of glucose transporter function in Leishmania mexicana. Proceedings of the National Academy of Sciences of the United States of America, 100(7), pp. 3901-3906. (doi:10.1073/pnas.0630165100)

Burchmore, R., Wallace, L., Candlish, D., Al-Salabi, M., Beal, P., Barrett, M., Baldwin, S. and de Koning, H. (2003) Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan. Journal of Biological Chemistry, 278(26), pp. 23502-23507. (doi:10.1074/jbc.M301252200)

Matovu, E. et al. (2003) Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryotic Cell, 2(5), pp. 1003-1008. (doi:10.1128/EC.2.5.1003-1008.2003)

Maugeri, D., Cazzulo, J., Burchmore, R., Barrett, M. and Ogbunude, P. (2003) Pentose phosphate metabolism in Leishmania mexicana. Molecular and Biochemical Parasitology, 130(2), pp. 117-125. (doi:10.1016/S0166-6851(03)00173-7)

Leslie, G., Barrett, M. and Burchmore, R. (2002) Leishmania mexicana: promastigotes migrate through osmotic gradients. Experimental Parasitology, 102(2), pp. 117-120. (doi:10.1016/S0014-4894(03)00031-6)

Burchmore, R., Ogbunude, P., Enanga, B. and Barrett, M. (2002) Chemotherapy of human African trypanosomiasis. Current Pharmaceutical Design, 8(4), pp. 257-267. (doi:10.2174/1381612023396159)

Enanga, B., Burchmore, R., Stewart, M. and Barrett, M. (2002) Sleeping sickness and the brain. Cellular and Molecular Life Sciences, 59(5), pp. 845-858. (doi:10.1007/s00018-002-8472-0)

Burchmore, R. and Barrett, M. (2001) Life in vacuoles - nutrient acquisition by Leishmania amastigotes. International Journal for Parasitology, 31(12), pp. 1311-1320. (doi:10.1016/S0020-7519(01)00259-4)

Conference Proceedings

Mudaliar, M., Thomas, F., McLaughlin, M., Burchmore, R., Wilson, D., Herzyk, P., Eckersall, P. and Zadoks, R. (2015) Using label-free quantitative proteomics and untargeted metabolomics to study bovine mastitis. In: Science with Impact – BSAS Annual Conference 2015, University of Chester, UK, 14-15 Apr 2015, p. 70. (doi:10.1017/S2040470015000023)

Mudaliar, M., Thomas, F., McLaughlin, M., Burchmore, R., Herzyk, P., Eckersall, P. and Zadoks, R. (2014) Integrative label-free quantitative proteomics study in mastitis. In: Final Showcase Meeting of Farm Animal Proteomics, Milan, Italy, 17-18 Nov 2014, pp. 98-101. ISBN 9789086868100 (doi:10.3920/978-90-8686-810-0)

This list was generated on Mon Sep 18 23:23:05 2017 BST.