Dr Pasquale Maffia

  • Senior Lecturer (Immunology)
  • Honorary Senior Lecturer (Institute of Cardiovascular and Medical Sciences)
  • Associate - Life Sciences (School of Life Sciences)

telephone: 01413307142
email: Pasquale.Maffia@glasgow.ac.uk

Research interests

Dr. Maffia has a major interest in the immune response in cardiovascular diseases. Current research activities address the study of cellular and molecular mechanisms involved in the pathophysiology of atherosclerosis, neointimal formation and stroke.

Immune responses play a key role in cardiovascular diseases. We have developed techniques to track antigen presenting cells and antigen presentation in the development of vascular immune response (ATVB 2012;32:2569-79; Pharmacol Ther. 2013;137:172-82). We have been amongst the first to apply multiphoton microscopy in experimental atherosclerosis (Circulation 2007;115:e326-8) and stroke (Stroke 2011;42:1429-36) with the aim to define the kinetics and anatomical location of the T cell-APC interactions which underlie vascular immune response in real-time in vivo. We are developing novel immuno-modulatory-based strategies to control neointimal formation and restenosis (Cardiovasc Res. 2009;84:485-93; ATVB 2011;31:2448-54).

Collaborations are established with researchers locally (Profs Garside, Brewer, McInnes, Sattar, Dr. Kennedy), nationally (Prof Graham, University of Strathclyde; Prof. Mallat, University of Cambridge; Prof. Shu, William Harvey Research Institute) and internationally (Prof. Ialenti, Napoli, Italy; Prof. Habenicht, Munich, Germany; Dr. Maiuri, Paris, France).

Dr Maffia's lab is supported by several funding agencies including the British Heart Foundation, EPSRC, Medical Research Scotland, SULSA and Nuffield Foundation

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Selective targeting of NF-kB by Bel-3 in the control of vascular injury
    Tenovus-Scotland
    2016 - 2017
     
  • ISSF Catalyst - FANTOM6 consortium investigation of the role of LncRNAs in specifying tissue macrophage phenotypes
    Wellcome Trust
    2015 - 2016
     
  • NanoMATe
    European Commission
    2015 - 2017
     
  • In Situ Nanoparticle Assemblies for Healthcare Diagnostics and Therapy
    Engineering & Physical Sciences Research Council
    2014 - 2018
     
  • BHF Centre of Excellence
    British Heart Foundation
    2014 - 2019
     
  • Defining innate and adaptive immune functions of plasmacytoid dendritic cells in atherosclerosis.
    British Heart Foundation
    2013 - 2016
     
  • Imaging immune cells in lung in order to understand asthma
    Asthma-UK
    2012 - 2012
     
  • Transfer of expertise in bioimaging from academia to industry.
    Scottish Funding Council
    2011 - 2012
     
  • Targeting cell contact to reduce autoimmunity and enhance vaccination
    Scottish Universities Life Sciences Alliance
    2011 - 2012
     
  • BINDARIT STUDY
    Angelini I Santa Palomba Research and Enterprise
    2010 - 2011
     
  • In Vivo Reporting using Nanosystems Chemistry and Optical Spectroscopy
    EPSRC
    2010 - 2011
     
  • Visualising antigen presentation in mouse models of atherosclerosis
    Medical Research Scotland
    2010 - 2012
     
  • Investigating the role of T cells in vascular pathology
    British Heart Foundation
    2010 - 2010
     
  • Importance of mast cells in vein graft survival
    British Heart Foundation
    2010 - 2012
     
  • BINDARIT STUDY
    Angelini I Santa Palomba Research and Enterprise
    2008 - 2009
     

Publications

List by: Type | Date

Jump to: 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1996
Number of items: 53.

2017

Welsh, P. , Grassia, G., Botha, S., Sattar, N. and Maffia, P. (2017) Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect? British Journal of Pharmacology, (doi:10.1111/bph.13818) (PMID:28409825) (Early Online Publication)

Yin, C., Mohanta, S., Maffia, P. and Habenicht, A. J.R. (2017) Editorial: Tertiary Lymphoid Organs (TLOs): powerhouses of diseaseiImmunity. Frontiers in Immunology, 8, p. 228. (doi:10.3389/fimmu.2017.00228) (PMID:28321222) (PMCID:PMC5337484)

Yin, C., Mohanta, S., Maffia, P. and Habenicht, A. J.R. (2017) Tertiary lymphoid organs (TLOs): powerhouses of disease immunity. Frontiers in Immunology, 8, 228. (doi:10.3389/fimmu.2017.00228)

Maffia, P., Döring, Y., Biessen, E. A.L. and Mallat, Z. (2017) Commentary: Indoleamine 2,3-dioxygenase-expressing aortic plasmacytoid dendritic cells protect against atherosclerosis by induction of regulatory T cells. Frontiers in Immunology, 10(8), 140. (doi:10.3389/fimmu.2017.00140) (PMID:28243244) (PMCID:PMC5304905)

2016

Hughes, C. E., Benson, R. A., Bedaj, M. and Maffia, P. (2016) Antigen-presenting cells and antigen presentation in tertiary lymphoid organs. Frontiers in Immunology, 7, 481. (doi:10.3389/fimmu.2016.00481) (PMID:27872626) (PMCID:PMC5097899)

Srikakulapu, P. et al. (2016) Artery tertiary lymphoid organs control multi-layered territorialized atherosclerosis B cell responses in aged ApoE-/- mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 36, pp. 1174-1185. (doi:10.1161/ATVBAHA.115.306983) (PMID:27102965) (PMCID:PMC4894775)

Scales, H. E. , Ierna, M., Smith, K. M., Ross, K., Meiklejohn, G. R., Patterson-Kane, J. C., McInnes, I. B., Brewer, J. M., Garside, P. and Maffia, P. (2016) Assessment of murine collagen-induced arthritis by longitudinal non-invasive duplexed molecular optical imaging. Rheumatology, 55(3), pp. 564-572. (doi:10.1093/rheumatology/kev361) (PMID:26475798)

2015

Wu, J., Grassia, G., Cambrook, H., Ialenti, A., MacRitchie, N., Carberry, J., Wadsworth, R. M., Lawrence, C., Kennedy, S. and Maffia, P. (2015) Perivascular mast cells regulate vein graft neointimal formation and remodeling. PeerJ, 3, e1192. (doi:10.7717/peerj.1192) (PMID:26312183) (PMCID:PMC4548472)

Collins, P. E., Grassia, G., Colleran, A., Kiely, P. A., Ialenti, A., Maffia, P. and Carmody, R. J. (2015) Mapping the interaction of B cell Leukemia 3 (BCL-3) and nuclear factor κB (NF-κB) p50 identifies a BCL-3-mimetic anti-inflammatory peptide. Journal of Biological Chemistry, 290(25), pp. 15687-15696. (doi:10.1074/jbc.M115.643700) (PMID:25922067)

Hu, D. et al. (2015) Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity, 42(6), pp. 1100-1115. (doi:10.1016/j.immuni.2015.05.015) (PMID:26084025) (PMCID:PMC4678289)

2014

Xiao, Q. et al. (2014) Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(1), pp. 90-98. (doi:10.1161/ATVBAHA.113.301418) (PMID:24158518)

Maddaluno, M., MacRitchie, N., Grassia, G., Ialenti, A., Butcher, J. P., Garside, P., Brewer, J. M. and Maffia, P. (2014) Murine aortic smooth muscle cells acquire, though fail to present exogenous protein antigens on major histocompatibility complex class II molecules. BioMed Research International(949845), (doi:10.1155/2014/949845) (PMID:25136640) (PMCID:PMC4127268)

Sage, A. P. et al. (2014) MHC class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity. Circulation, 130(16), pp. 1363-1373. (doi:10.1161/CIRCULATIONAHA.114.011090) (PMID:25223984) (PMCID:PMC4428652)

2013

Kennedy, S., Wu, J., Wadsworth, R.M., Lawrence, C.E. and Maffia, P. (2013) Mast cells and vascular diseases. Pharmacology and Therapeutics, 138(1), pp. 53-65. (doi:10.1016/j.pharmthera.2013.01.001)

Grassia, G., MacRitchie, N., Platt, A., Brewer, J., Garside, P. and Maffia, P. (2013) Plasmacytoid dendritic cells: biomarkers or potential therapeutic targets in atherosclerosis? Pharmacology and Therapeutics, 137(2), pp. 172-182. (doi:10.1016/j.pharmthera.2012.10.001) (PMID:23059425)

Maiuri, M.C., Grassia, G., Platt, A., Carnuccio, R., Ialenti, A. and Maffia, P. (2013) Macrophage autophagy in atherosclerosis. Mediators of Inflammation, 2013, Art. 584715. (doi:10.1155/2013/584715)

2012

MacRitchie, N. et al. (2012) Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein e-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(11), pp. 2569-2579. (doi:10.1161/ATVBAHA.112.251314)

Gibson, V.B. et al. (2012) A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo. Blood, 119(11), pp. 2545-2551. (doi:10.1182/blood-2011-09-378356) (PMID:22271449) (PMCID:PMC3398133)

Maddaluno, M. et al. (2012) Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching. PLoS ONE, 7(10), e47464. (doi:10.1371/journal.pone.0047464)

McQueenie, R., Stevenson, R., Benson, R., MacRitchie, N., McInnes, I., Maffia, P., Faulds, K., Graham, D., Brewer, J. and Garside, P. (2012) Detection of inflammation in vivo by surface-enhanced raman scattering provides higher sensitivity than conventional fluorescence imaging. Analytical Chemistry, 84(14), pp. 5968-5975. (doi:10.1021/ac3006445)

2011

Ialenti, A. et al. (2011) Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(11), pp. 2448-2454. (doi:10.1161/ATVBAHA.111.230078) (PMID:21852559)

Patakas, A., Platt, A. M., Butcher, J. P., Maffia, P., McInnes, I. B., Brewer, J. M., Garside, P. and Benson, R. A. (2011) Putative existence of reciprocal dialogue between Tfh and B cells and its impact on infectious and autoimmune disease. Immunology Letters, 138(1), pp. 38-46. (doi:10.1016/j.imlet.2011.03.002) (PMID:21419798)

Fumagalli, S. et al. (2011) In vivo real-time multiphoton imaging of t lymphocytes in the mouse brain after experimental stroke. Stroke, 42(5), pp. 1429-1436. (doi:10.1161/STROKEAHA.110.603704)

2010

Grassia, G. et al. (2010) The IkB kinase inhibitor nuclear factor-kB essential modulator–binding domain peptide for inhibition of balloon injury-induced neointimal formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(12), pp. 2458-2466. (doi:10.1161/ATVBAHA.110.215467)

Ortolano, F., Maffia, P., Dever, G., Millington, O., De Simoni, M., Brewer, J., Bushell, T.J., Garside, P. and Carswell, H.V. (2010) Advances in imaging of new targets for pharmacological intervention in stroke: real-time tracking of T-cells in the ischaemic brain. British Journal of Pharmacology, 159(4), pp. 808-811. (doi:10.1111/j.1476-5381.2009.00527.x)

Millington, O. R., Brewer, J. M., Garside, P. and Maffia, P. (2010) Imaging interactions between the immune and cardiovascular systems in vivo by multiphoton microscopy. In: Marelli-Berg, F. M. and Nourshargh, S. (eds.) T-Cell Trafficking: Methods and Protocols. Series: Methods in Molecular Biology, 616 (616). Humana Press Inc, pp. 193-206. ISBN 9781607614609 (doi:10.1007/978-1-60761-461-6_13)

2009

Grassia, G., Maddaluno, M., Guglielmotti, A., Mangano, G., Biondi, G., Maffia, P. and Ialenti, A. (2009) The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice. Cardiovascular Research, 84(3), pp. 485-493. (doi:10.1093/cvr/cvp238)

D'Emmanuele di Villa Bianca, R., Sorrentino, R., Maffia, P., Mirone, F., Imbimbo, C., Fusco, F., De Palma, R., Ignarro, L.J. and Cirino, G. (2009) Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation. Proceedings of the National Academy of Sciences of the United States of America, 106(11), pp. 4513-4518. (doi:10.1073/pnas.0807974105)

Ortolano, F. et al. (2009) Imaging T-cell movement in the brain during experimental cerebral malaria. Parasite Immunology, 31(3), 147-150 (4). (doi:10.1111/j.1365-3024.2008.01090.x)

2007

Maffia, P., Zinselmeyer, B.H., Ialenti, A., Kennedy, S., Baker, A.H., McInnes, I., Brewer, J.M. and Garside, P. (2007) Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery. Circulation, 115(11), E326-E328. (doi:10.1161/CIRCULATIONAHA.106.658492) (PMID:17372180)

2006

Maffia, P., Grassia, G., Di Meglio, P., Carnuccio, R., Berrino, L., Garside, P., Ianaro, A. and Ialenti, A. (2006) Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injury. Circulation, 114, pp. 430-437. (doi:10.1161/CIRCULATIONAHA.105.602714) (PMID:16864728)

Ialenti, A., Di Meglio, P., Grassia, G., Maffia, P., Di Rosa, M., Lanzetta, R., Molinaro, A., Silipo, A., Grant, W. and Ianaro, A. (2006) A novel lipid A fromHalomonas magadiensis inhibits enteric LPS-induced human monocyte activation. European Journal of Immunology, 36(2), pp. 354-360. (doi:10.1002/eji.200535305) (PMID:16365914)

2005

Morello, S., Vellecco, V., Roviezzo, F., Maffia, P., Cuzzocrea, S., Cirino, G. and Cicala, C. (2005) A protective role for proteinase activated receptor 2 in airways of lipopolysaccharide-treated rats. Biochemical Pharmacology, 71(1-2), pp. 223-230. (doi:10.1016/j.bcp.2005.10.016) (PMID:16300746)

Corea, G., Fattorusso, E., Lanzotti, V., Di Meglio, P., Maffia, P., Grassia, G., Ialenti, A. and Ianaro, A. (2005) Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agent. Journal of Medicinal Chemistry, 48(22), pp. 7055-7062. (doi:10.1021/jm050321r) (PMID:16250665)

Ialenti, A., Grassia, G., Di Meglio, P., Maffia, P., Di Rosa, M. and Ianaro, A. (2005) Mechanism of the anti-inflammatory effect of thiazolidinediones: relationship with the glucocorticoid pathway. Molecular Pharmacology, 67(5), pp. 1620-1628. (doi:10.1124/mol.104.004895) (PMID:15684043)

Ialenti, A., Di Meglio, P., D'Acquisto, F., Pisano, B., Maffia, P., Grassia, G., Di Rosa, M. and Ianaro, A. (2005) Inhibition of cyclooxygenase-2 gene expression by the heat shock response in J774 murine macrophages. European Journal of Pharmacology, 509(2-3), pp. 89-96. (doi:10.1016/j.ejphar.2004.10.052) (PMID:15733543)

2004

Maffia, P., Brewer, J.M., Gracie, J.A., Ianaro, A., Leung, B.P., Mitchell, P.J., Smith, K., McInnes, I. B. and Garside, P. (2004) Inducing experimental arthritis and breaking self-tolerance to joint-specific antigens with trackable, ovalbumin-specific T cells. Journal of Immunology, 173(1), pp. 151-156. (doi:10.4049/jimmunol.173.1.151) (PMID:15210769)

Cuzzocrea, S. et al. (2004) Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-γ, reduces acute inflammation. European Journal of Pharmacology, 483(1), pp. 79-93. (doi:10.1016/j.ejphar.2003.10.056) (PMID:14709329)

2003

Lippolis, L., Sorrentino, R., Popolo, A., Maffia, P., Nasti, C., Villa Bianca, R. d.’E. d., Marzocco, S., Autore, G. and Pinto, A. (2003) Time course of vascular reactivity to contracting and relaxing agents after endothelial denudation by balloon angioplasty in rat carotid artery. Atherosclerosis, 171(2), pp. 171-179. (doi:10.1016/j.atherosclerosis.2003.07.012) (PMID:14644385)

Ianaro, A., Maffia, P., Cuzzocrea, S., Mazzon, E., Santoro, M. G., Di Rosa, M. and Ialenti, A. (2003) 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-κB. FEBS Letters, 553(1-2), pp. 21-27. (doi:10.1016/S0014-5793(03)00873-1) (PMID:14550540)

Ianaro, A., Ialenti, A., Maffia, P., Di Meglio, P., Di Rosa, M. and Santoro, M. G. (2003) Anti-inflammatory activity of 15-deoxy- 12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response. Molecular Pharmacology, 64(1), pp. 85-93. (doi:10.1124/mol.64.1.85) (PMID:12815164)

2002

Mascolo, N., Izzo, A. A., Ligresti, A., Costagliola, A., Pinto, L., Cascio, M. G., Maffia, P., Cecio, A., Capasso, F. and Di Marzo, V. (2002) The endocannabinoid system and the molecular basis of paralytic ileus in mice. FASEB Journal, (doi:10.1096/fj.02-0338fje) (PMID:12397089)

Borrelli, F., Izzo, A.A., Di Carlo, G., Maffia, P., Russo, A., Maiello, F.M., Capasso, F. and Mascolo, N. (2002) Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon. Fitoterapia, 73(Supl 1), S38-S43. (doi:10.1016/S0367-326X(02)00189-2) (PMID:12495708)

Borrelli, F., Maffia, P., Pinto, L., Ianaro, A., Russo, A., Capasso, F. and Ialenti, A. (2002) Phytochemical compounds involved in the anti-inflammatory effect of propolis extract. Fitoterapia, 73(Supl 1), S53-S63. (doi:10.1016/S0367-326X(02)00191-0) (PMID:12495710)

Maffia, P., Ianaro, A., Sorrentino, R., Lippolis, L., Maiello, F. M., del Soldato, P., Ialenti, A. and Cirino, G. (2002) Beneficial effects of NO-releasing derivative of flurbiprofen (HCT-1026) in rat model of vascular injury and restenosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 22(2), pp. 263-267. (PMID:11834526)

2001

Ianaro, A., Ialenti, A., Maffia, P., Pisano, B. and Di Rosa, M. (2001) Role of cyclopentenone prostaglandins in rat carrageenin pleurisy. FEBS Letters, 508(1), pp. 61-66. (doi:10.1016/S0014-5793(01)03035-6) (PMID:11707269)

D'Acquisto, F., Ianaro, A., Ialenti, A., Maffia, P., Maiuri, M. and Carnuccio, R. (2001) Transcription factor decoy oligodeoxynucleotides to nuclear factor-κB inhibit reverse passive Arthus reaction in rat. Naunyn-Schmiedeberg's Archives of Pharmacology, 364(5), pp. 422-429. (doi:10.1007/s002100100472) (PMID:11692225)

Ianaro, A., Ialenti, A., Maffia, P., Pisano, B. and Di Rosa, M. (2001) HSF1/hsp72 pathway as an endogenous anti-inflammatory system. FEBS Letters, 499(3), pp. 239-244. (doi:10.1016/S0014-5793(01)02569-8) (PMID:11423124)

Ialenti, A. et al. (2001) Synthesis of novel anti-inflammatory peptides derived from the amino-acid sequence of the bioactive protein SV-IV. European Journal of Biochemistry, 268(12), pp. 3399-3406. (doi:10.1046/j.1432-1327.2001.02236.x) (PMID:11422369)

2000

Ialenti, A., Ianaro, A., Maffia, P., Sautebin, L. and Di Rosa, M. (2000) Nitric oxide inhibits leucocyte migration in carrageenin-induced rat pleurisy. Inflammation Research, 49(8), pp. 411-417. (doi:10.1007/s000110050609) (PMID:11028758)

Ianaro, A., Ialenti, A., Maffia, P., Sautebin, L., Rombolà, L., Carnuccio, R., Iuvone, T., D'Acquisto, F. and Di Rosa, M. (2000) Anti-inflammatory activity of macrolide antibiotics. Journal of Pharmacology and Experimental Therapeutics, 292(1), pp. 156-163. (PMID:10604943)

1996

Costantino, V., Fattorusso, E., Mangoni, A., Rosa, M. D., Ianaro, A. and Maffia, P. (1996) Glycolipids from sponges. IV. Immunomodulating glycosyl ceramides from the marine sponge agelas dispar. Tetrahedron, 52(5), pp. 1573-1578. (doi:10.1016/0040-4020(95)00986-8)

Caliendo, G., Greco, G., Grieco, P., Perissutti, E., Santagada, V., Ialenti, A., Maffia, P., Albrizio, S. and Santini, A. (1996) Synthesis and antinociceptive activity of peptides related to interleukin-1β193–195 Lys-Pro-Thr. Biopolymers, 40(5), pp. 479-484. (doi:10.1002/(SICI)1097-0282(1996)40:5<479::AID-BIP5>3.0.CO;2-T) (PMID:9062070)

This list was generated on Mon Sep 18 19:46:20 2017 BST.
Number of items: 53.

Articles

Welsh, P. , Grassia, G., Botha, S., Sattar, N. and Maffia, P. (2017) Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect? British Journal of Pharmacology, (doi:10.1111/bph.13818) (PMID:28409825) (Early Online Publication)

Yin, C., Mohanta, S., Maffia, P. and Habenicht, A. J.R. (2017) Editorial: Tertiary Lymphoid Organs (TLOs): powerhouses of diseaseiImmunity. Frontiers in Immunology, 8, p. 228. (doi:10.3389/fimmu.2017.00228) (PMID:28321222) (PMCID:PMC5337484)

Yin, C., Mohanta, S., Maffia, P. and Habenicht, A. J.R. (2017) Tertiary lymphoid organs (TLOs): powerhouses of disease immunity. Frontiers in Immunology, 8, 228. (doi:10.3389/fimmu.2017.00228)

Maffia, P., Döring, Y., Biessen, E. A.L. and Mallat, Z. (2017) Commentary: Indoleamine 2,3-dioxygenase-expressing aortic plasmacytoid dendritic cells protect against atherosclerosis by induction of regulatory T cells. Frontiers in Immunology, 10(8), 140. (doi:10.3389/fimmu.2017.00140) (PMID:28243244) (PMCID:PMC5304905)

Hughes, C. E., Benson, R. A., Bedaj, M. and Maffia, P. (2016) Antigen-presenting cells and antigen presentation in tertiary lymphoid organs. Frontiers in Immunology, 7, 481. (doi:10.3389/fimmu.2016.00481) (PMID:27872626) (PMCID:PMC5097899)

Srikakulapu, P. et al. (2016) Artery tertiary lymphoid organs control multi-layered territorialized atherosclerosis B cell responses in aged ApoE-/- mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 36, pp. 1174-1185. (doi:10.1161/ATVBAHA.115.306983) (PMID:27102965) (PMCID:PMC4894775)

Scales, H. E. , Ierna, M., Smith, K. M., Ross, K., Meiklejohn, G. R., Patterson-Kane, J. C., McInnes, I. B., Brewer, J. M., Garside, P. and Maffia, P. (2016) Assessment of murine collagen-induced arthritis by longitudinal non-invasive duplexed molecular optical imaging. Rheumatology, 55(3), pp. 564-572. (doi:10.1093/rheumatology/kev361) (PMID:26475798)

Wu, J., Grassia, G., Cambrook, H., Ialenti, A., MacRitchie, N., Carberry, J., Wadsworth, R. M., Lawrence, C., Kennedy, S. and Maffia, P. (2015) Perivascular mast cells regulate vein graft neointimal formation and remodeling. PeerJ, 3, e1192. (doi:10.7717/peerj.1192) (PMID:26312183) (PMCID:PMC4548472)

Collins, P. E., Grassia, G., Colleran, A., Kiely, P. A., Ialenti, A., Maffia, P. and Carmody, R. J. (2015) Mapping the interaction of B cell Leukemia 3 (BCL-3) and nuclear factor κB (NF-κB) p50 identifies a BCL-3-mimetic anti-inflammatory peptide. Journal of Biological Chemistry, 290(25), pp. 15687-15696. (doi:10.1074/jbc.M115.643700) (PMID:25922067)

Hu, D. et al. (2015) Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity, 42(6), pp. 1100-1115. (doi:10.1016/j.immuni.2015.05.015) (PMID:26084025) (PMCID:PMC4678289)

Xiao, Q. et al. (2014) Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(1), pp. 90-98. (doi:10.1161/ATVBAHA.113.301418) (PMID:24158518)

Maddaluno, M., MacRitchie, N., Grassia, G., Ialenti, A., Butcher, J. P., Garside, P., Brewer, J. M. and Maffia, P. (2014) Murine aortic smooth muscle cells acquire, though fail to present exogenous protein antigens on major histocompatibility complex class II molecules. BioMed Research International(949845), (doi:10.1155/2014/949845) (PMID:25136640) (PMCID:PMC4127268)

Sage, A. P. et al. (2014) MHC class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity. Circulation, 130(16), pp. 1363-1373. (doi:10.1161/CIRCULATIONAHA.114.011090) (PMID:25223984) (PMCID:PMC4428652)

Kennedy, S., Wu, J., Wadsworth, R.M., Lawrence, C.E. and Maffia, P. (2013) Mast cells and vascular diseases. Pharmacology and Therapeutics, 138(1), pp. 53-65. (doi:10.1016/j.pharmthera.2013.01.001)

Grassia, G., MacRitchie, N., Platt, A., Brewer, J., Garside, P. and Maffia, P. (2013) Plasmacytoid dendritic cells: biomarkers or potential therapeutic targets in atherosclerosis? Pharmacology and Therapeutics, 137(2), pp. 172-182. (doi:10.1016/j.pharmthera.2012.10.001) (PMID:23059425)

Maiuri, M.C., Grassia, G., Platt, A., Carnuccio, R., Ialenti, A. and Maffia, P. (2013) Macrophage autophagy in atherosclerosis. Mediators of Inflammation, 2013, Art. 584715. (doi:10.1155/2013/584715)

MacRitchie, N. et al. (2012) Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein e-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(11), pp. 2569-2579. (doi:10.1161/ATVBAHA.112.251314)

Gibson, V.B. et al. (2012) A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo. Blood, 119(11), pp. 2545-2551. (doi:10.1182/blood-2011-09-378356) (PMID:22271449) (PMCID:PMC3398133)

Maddaluno, M. et al. (2012) Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching. PLoS ONE, 7(10), e47464. (doi:10.1371/journal.pone.0047464)

McQueenie, R., Stevenson, R., Benson, R., MacRitchie, N., McInnes, I., Maffia, P., Faulds, K., Graham, D., Brewer, J. and Garside, P. (2012) Detection of inflammation in vivo by surface-enhanced raman scattering provides higher sensitivity than conventional fluorescence imaging. Analytical Chemistry, 84(14), pp. 5968-5975. (doi:10.1021/ac3006445)

Ialenti, A. et al. (2011) Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(11), pp. 2448-2454. (doi:10.1161/ATVBAHA.111.230078) (PMID:21852559)

Patakas, A., Platt, A. M., Butcher, J. P., Maffia, P., McInnes, I. B., Brewer, J. M., Garside, P. and Benson, R. A. (2011) Putative existence of reciprocal dialogue between Tfh and B cells and its impact on infectious and autoimmune disease. Immunology Letters, 138(1), pp. 38-46. (doi:10.1016/j.imlet.2011.03.002) (PMID:21419798)

Fumagalli, S. et al. (2011) In vivo real-time multiphoton imaging of t lymphocytes in the mouse brain after experimental stroke. Stroke, 42(5), pp. 1429-1436. (doi:10.1161/STROKEAHA.110.603704)

Grassia, G. et al. (2010) The IkB kinase inhibitor nuclear factor-kB essential modulator–binding domain peptide for inhibition of balloon injury-induced neointimal formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(12), pp. 2458-2466. (doi:10.1161/ATVBAHA.110.215467)

Ortolano, F., Maffia, P., Dever, G., Millington, O., De Simoni, M., Brewer, J., Bushell, T.J., Garside, P. and Carswell, H.V. (2010) Advances in imaging of new targets for pharmacological intervention in stroke: real-time tracking of T-cells in the ischaemic brain. British Journal of Pharmacology, 159(4), pp. 808-811. (doi:10.1111/j.1476-5381.2009.00527.x)

Grassia, G., Maddaluno, M., Guglielmotti, A., Mangano, G., Biondi, G., Maffia, P. and Ialenti, A. (2009) The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice. Cardiovascular Research, 84(3), pp. 485-493. (doi:10.1093/cvr/cvp238)

D'Emmanuele di Villa Bianca, R., Sorrentino, R., Maffia, P., Mirone, F., Imbimbo, C., Fusco, F., De Palma, R., Ignarro, L.J. and Cirino, G. (2009) Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation. Proceedings of the National Academy of Sciences of the United States of America, 106(11), pp. 4513-4518. (doi:10.1073/pnas.0807974105)

Ortolano, F. et al. (2009) Imaging T-cell movement in the brain during experimental cerebral malaria. Parasite Immunology, 31(3), 147-150 (4). (doi:10.1111/j.1365-3024.2008.01090.x)

Maffia, P., Zinselmeyer, B.H., Ialenti, A., Kennedy, S., Baker, A.H., McInnes, I., Brewer, J.M. and Garside, P. (2007) Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery. Circulation, 115(11), E326-E328. (doi:10.1161/CIRCULATIONAHA.106.658492) (PMID:17372180)

Maffia, P., Grassia, G., Di Meglio, P., Carnuccio, R., Berrino, L., Garside, P., Ianaro, A. and Ialenti, A. (2006) Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injury. Circulation, 114, pp. 430-437. (doi:10.1161/CIRCULATIONAHA.105.602714) (PMID:16864728)

Ialenti, A., Di Meglio, P., Grassia, G., Maffia, P., Di Rosa, M., Lanzetta, R., Molinaro, A., Silipo, A., Grant, W. and Ianaro, A. (2006) A novel lipid A fromHalomonas magadiensis inhibits enteric LPS-induced human monocyte activation. European Journal of Immunology, 36(2), pp. 354-360. (doi:10.1002/eji.200535305) (PMID:16365914)

Morello, S., Vellecco, V., Roviezzo, F., Maffia, P., Cuzzocrea, S., Cirino, G. and Cicala, C. (2005) A protective role for proteinase activated receptor 2 in airways of lipopolysaccharide-treated rats. Biochemical Pharmacology, 71(1-2), pp. 223-230. (doi:10.1016/j.bcp.2005.10.016) (PMID:16300746)

Corea, G., Fattorusso, E., Lanzotti, V., Di Meglio, P., Maffia, P., Grassia, G., Ialenti, A. and Ianaro, A. (2005) Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agent. Journal of Medicinal Chemistry, 48(22), pp. 7055-7062. (doi:10.1021/jm050321r) (PMID:16250665)

Ialenti, A., Grassia, G., Di Meglio, P., Maffia, P., Di Rosa, M. and Ianaro, A. (2005) Mechanism of the anti-inflammatory effect of thiazolidinediones: relationship with the glucocorticoid pathway. Molecular Pharmacology, 67(5), pp. 1620-1628. (doi:10.1124/mol.104.004895) (PMID:15684043)

Ialenti, A., Di Meglio, P., D'Acquisto, F., Pisano, B., Maffia, P., Grassia, G., Di Rosa, M. and Ianaro, A. (2005) Inhibition of cyclooxygenase-2 gene expression by the heat shock response in J774 murine macrophages. European Journal of Pharmacology, 509(2-3), pp. 89-96. (doi:10.1016/j.ejphar.2004.10.052) (PMID:15733543)

Maffia, P., Brewer, J.M., Gracie, J.A., Ianaro, A., Leung, B.P., Mitchell, P.J., Smith, K., McInnes, I. B. and Garside, P. (2004) Inducing experimental arthritis and breaking self-tolerance to joint-specific antigens with trackable, ovalbumin-specific T cells. Journal of Immunology, 173(1), pp. 151-156. (doi:10.4049/jimmunol.173.1.151) (PMID:15210769)

Cuzzocrea, S. et al. (2004) Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-γ, reduces acute inflammation. European Journal of Pharmacology, 483(1), pp. 79-93. (doi:10.1016/j.ejphar.2003.10.056) (PMID:14709329)

Lippolis, L., Sorrentino, R., Popolo, A., Maffia, P., Nasti, C., Villa Bianca, R. d.’E. d., Marzocco, S., Autore, G. and Pinto, A. (2003) Time course of vascular reactivity to contracting and relaxing agents after endothelial denudation by balloon angioplasty in rat carotid artery. Atherosclerosis, 171(2), pp. 171-179. (doi:10.1016/j.atherosclerosis.2003.07.012) (PMID:14644385)

Ianaro, A., Maffia, P., Cuzzocrea, S., Mazzon, E., Santoro, M. G., Di Rosa, M. and Ialenti, A. (2003) 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-κB. FEBS Letters, 553(1-2), pp. 21-27. (doi:10.1016/S0014-5793(03)00873-1) (PMID:14550540)

Ianaro, A., Ialenti, A., Maffia, P., Di Meglio, P., Di Rosa, M. and Santoro, M. G. (2003) Anti-inflammatory activity of 15-deoxy- 12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response. Molecular Pharmacology, 64(1), pp. 85-93. (doi:10.1124/mol.64.1.85) (PMID:12815164)

Mascolo, N., Izzo, A. A., Ligresti, A., Costagliola, A., Pinto, L., Cascio, M. G., Maffia, P., Cecio, A., Capasso, F. and Di Marzo, V. (2002) The endocannabinoid system and the molecular basis of paralytic ileus in mice. FASEB Journal, (doi:10.1096/fj.02-0338fje) (PMID:12397089)

Borrelli, F., Izzo, A.A., Di Carlo, G., Maffia, P., Russo, A., Maiello, F.M., Capasso, F. and Mascolo, N. (2002) Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon. Fitoterapia, 73(Supl 1), S38-S43. (doi:10.1016/S0367-326X(02)00189-2) (PMID:12495708)

Borrelli, F., Maffia, P., Pinto, L., Ianaro, A., Russo, A., Capasso, F. and Ialenti, A. (2002) Phytochemical compounds involved in the anti-inflammatory effect of propolis extract. Fitoterapia, 73(Supl 1), S53-S63. (doi:10.1016/S0367-326X(02)00191-0) (PMID:12495710)

Maffia, P., Ianaro, A., Sorrentino, R., Lippolis, L., Maiello, F. M., del Soldato, P., Ialenti, A. and Cirino, G. (2002) Beneficial effects of NO-releasing derivative of flurbiprofen (HCT-1026) in rat model of vascular injury and restenosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 22(2), pp. 263-267. (PMID:11834526)

Ianaro, A., Ialenti, A., Maffia, P., Pisano, B. and Di Rosa, M. (2001) Role of cyclopentenone prostaglandins in rat carrageenin pleurisy. FEBS Letters, 508(1), pp. 61-66. (doi:10.1016/S0014-5793(01)03035-6) (PMID:11707269)

D'Acquisto, F., Ianaro, A., Ialenti, A., Maffia, P., Maiuri, M. and Carnuccio, R. (2001) Transcription factor decoy oligodeoxynucleotides to nuclear factor-κB inhibit reverse passive Arthus reaction in rat. Naunyn-Schmiedeberg's Archives of Pharmacology, 364(5), pp. 422-429. (doi:10.1007/s002100100472) (PMID:11692225)

Ianaro, A., Ialenti, A., Maffia, P., Pisano, B. and Di Rosa, M. (2001) HSF1/hsp72 pathway as an endogenous anti-inflammatory system. FEBS Letters, 499(3), pp. 239-244. (doi:10.1016/S0014-5793(01)02569-8) (PMID:11423124)

Ialenti, A. et al. (2001) Synthesis of novel anti-inflammatory peptides derived from the amino-acid sequence of the bioactive protein SV-IV. European Journal of Biochemistry, 268(12), pp. 3399-3406. (doi:10.1046/j.1432-1327.2001.02236.x) (PMID:11422369)

Ialenti, A., Ianaro, A., Maffia, P., Sautebin, L. and Di Rosa, M. (2000) Nitric oxide inhibits leucocyte migration in carrageenin-induced rat pleurisy. Inflammation Research, 49(8), pp. 411-417. (doi:10.1007/s000110050609) (PMID:11028758)

Ianaro, A., Ialenti, A., Maffia, P., Sautebin, L., Rombolà, L., Carnuccio, R., Iuvone, T., D'Acquisto, F. and Di Rosa, M. (2000) Anti-inflammatory activity of macrolide antibiotics. Journal of Pharmacology and Experimental Therapeutics, 292(1), pp. 156-163. (PMID:10604943)

Costantino, V., Fattorusso, E., Mangoni, A., Rosa, M. D., Ianaro, A. and Maffia, P. (1996) Glycolipids from sponges. IV. Immunomodulating glycosyl ceramides from the marine sponge agelas dispar. Tetrahedron, 52(5), pp. 1573-1578. (doi:10.1016/0040-4020(95)00986-8)

Caliendo, G., Greco, G., Grieco, P., Perissutti, E., Santagada, V., Ialenti, A., Maffia, P., Albrizio, S. and Santini, A. (1996) Synthesis and antinociceptive activity of peptides related to interleukin-1β193–195 Lys-Pro-Thr. Biopolymers, 40(5), pp. 479-484. (doi:10.1002/(SICI)1097-0282(1996)40:5<479::AID-BIP5>3.0.CO;2-T) (PMID:9062070)

Book Sections

Millington, O. R., Brewer, J. M., Garside, P. and Maffia, P. (2010) Imaging interactions between the immune and cardiovascular systems in vivo by multiphoton microscopy. In: Marelli-Berg, F. M. and Nourshargh, S. (eds.) T-Cell Trafficking: Methods and Protocols. Series: Methods in Molecular Biology, 616 (616). Humana Press Inc, pp. 193-206. ISBN 9781607614609 (doi:10.1007/978-1-60761-461-6_13)

This list was generated on Mon Sep 18 19:46:20 2017 BST.